>L1MC4A ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------TGAAA---------GATAA---AGTTTCTGAAATGAGGAATTCATTGGTT-- ---GGGCTCAATAGCAAA----------------TTAG--------------------AC A--CAAC------------------AGAAGAAAA-AAT-TAGAG--ACTTGGAACAT--- -AGGCTAACCATAG-------AATCAAGAAGC---------TGAGAGACACA---AAAAA AAGG---ATAAAAAGT-GA---------AGA---AGAGAGGGAAA--GGGACATAGAGG- ---AG--------G---TAAGAAA--CCCAAAC-------------TTGG--AATC---- ----------TCAGGAC----AGGAGAGAGAGAA---AATGAGTCAG---------AAAC AACATCC---CA-----AGAGATAATGGCC---ATCACTTCCCCAG-------------- ---------AGTAGCAGACAT--CAAG--CCATAGATTC-----AAGAAGCTCCAAAA-A CCCCAAGCA------------AGAAAAA-TAA--------------AAAGAAATCTACAC C-------A---------------------ATACACATCATAGTCAAATT------TCC- GAAAATGGAAA---CAAAGG--AAAAAATCT----------------------------- -------------TAAAAAC--AGTTAGAGA---AAAATGACACCT-------------- -----------TAC---TTATGGAGGAAAAAACTA--------------TTAGATA--AA CACCAGATTTC-----CTAGTGGAA--AACATG-AAGGC------CAG--AGGAAGTG-- -----------GCA---TTATCTT-------TTAAAG--TACT-------------AAAA GAAAA-------------G-AAT-TA--TCA--TCCCAGAA--------TTC---TATAT CCA-----------GTGAAAATATTC-----TGCAA-GAATGA-------AG-------- ------------------------G-GGGAATCAAGACATTTTCAAATAAAGAAAAT--- -AGAGA-ATTCATTACCAGAATAC---CTAGTTTAT-AAGAA------------------ --------------------TAGCTAAGAGA----------------------------- -----------------------------------AGCTC-------------------- -----------------------------------------------------TCTAAAA AGAAAGAACTCTTTATGAAACAAGT----------------------------------- -------------------------------ATAACATTTATACC--------------- ------------------------------------TAATCCT----------------- --------GATAAAAGAAAAAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------AAAA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GAGCA----- -------------------------------------------------------TAAAA --------------------------------------------------GTAGCAAT-- ------------------------------------------------------------ ---------------------CTAAGTAAAAT---------------------------- ------------------------------------------------------------ --------------------------------------------------ATTAGCAAAC ATAATTCCACACCACA-TTAAGAAAATAA------------------------------- ------------------------------------------------------------ ---------------------CACAAAATTTTAA--------------AAATCATGACCA AGTAG------------------------------------------------------- --------------------------------------------------------GATT TATTCCAGGAATGCAAGGTTGGTTCAATA------------------------------- ------------------TTAAG-------GAAATCCAT--------------------- ------------------------------------------------------------ --------------------TTAAAAATAC-ACAATATTAAT------AT-------ATC TAAG--GAGAA--AAATCA---CACAATTATCTCCATTGATGCTGAAAAAACCTTTAGAC AAAATTTAACACCCATAATG---------GATTTT----AAAA---AAATAGAAA----- ---TTG--------------------TGGGATACCTTCTT-AACATGATAAAATATTTAA AGTACCTTAGAACTAAAGCCAGTATCTTATTTAATGGGGAAACACTAGAGGCATTTC--- C----------------ACTA------AGATC---------------------AGGAACC AGGTAA--GGATGCC-CACTATCTCTACTACTATTCAACAT-TATTCTAGAGATATTAGC TAATGCAATTAG---ACAGGAGAAATCAATT-AGAGGCAT-----------------AAG AATGGA-------------------TAACAA---AGTA--------GT-AAAACTC-TCT TTATTTTCATATTATATGATA---GTATATCTG-----------GAAAACCTTAGAGAAT CAAT------GATAAAGCTAACTCAAACATA-----AA----AGAATAA---------AA TAAAATTCAGT------AATGTAGCAGGATATAAAATTAACATACAAAAGTCAATAGCCT TCATATACACAAACAATAACCAGTTAGAAGATATG------------------TTAGAC- -----AAAACCCCATTTATAATAGCAACAAAGAAAATAAAATACTTAGAAATAAACTTAA CA------AGAAATGT---GCAAAACCTATATGAAGA--AA-----------ATTTTAAA ACACTCCTAAAAAACACAA-------------AAGTA-----GA--ATT-GAACCAATCT --G----AAAGGCATCCCTTGTTCTTGG--ATAGAATGAC-------------------- -TCATAACA--------------TTATAAA----------------GATGTCAG------ ------TTCTTC------CTCAGTTAATTTACAAATTTAATTCAAG-------------- ----------------------------------------------CCCA--------AT --------------AAA------------AATACCAACAAGCTTTTTTATGGAGT----T AGACAAGTTGATACTTAAG---TT-TCATATG--GAAAAACAAACA-------TGCAAGA ATAGCCA---------------AGAAAACACTAA---AAAAC------------------ ------AAAAGATTATAA-GGAGGAAACTAGCCCTACCAG--ATATTAAAACATACTATA AAGCCTCTATAATTAAAACAGTGTGGTACTGGCTCGTGAATAGACAAACAGACCAATGGA ATAGAATACAAAGCCCAATAATAAGACCAAACTACATATGGAAATTTAGTATAGGATAT- --AAGGTAGCTGA---TAAAGGTTGCATCTC---A--GGGT--TTCAAATCACGTCCAAA GAGGACCTTTTAATGAATGGTGCTGGGACGATGGAGAG--TAGCCATTTGGAAAAAAAT- ------AAAATTAGATTCATATCTTACGTCATACACAAGAATA---AACTCCAAATAGAT AATAG------GG------------------------------------ATCTAAA---T GTAGAAAATAAAACCATGCTAGTA----CTAGAAGAAAACATGGGTGAATTCCTCTTTAA TCTAAA------------------------------------------------------ --------------------------------TAT-----AGGGAAAGGATTT---CTAT CTA-----TGACTCA--AAATCCAGATGCAATAAAAG------------------AAAAT A---TTGATAAATCT-----------------AACTATA--------TAAAAATTTTTT- ---------GCATAGTCAAA--AA--------------A---CATGAC-----------A AA-GACAAAGTCAAAAGACAACTGAC---------AAACT-----GGGAG---------- -----------AAA---ATATTTGC---------AACATATACCACAG---AT-AAAG-- GGCTAATATCCC----------CCATATA---------TAAAG---AACTCTTAA----- -AAATTGAGGGA----CAAAGGACCGAAAACCTGATA----------------------- AG---------------AA-AAATGAGAAAAGACATTAACA-----------GACAATTC ACAAAAGA-----------TATAAAAAAAAC---CGCCAATCAATTGATGAAAAAA---- -----------TGTTC----GACCTCAC-------------------TCATAATTAAAGA AATTCAAATTAT-----AAAAACTACACTGAGATA-CCATTT----------CTC----A CCTATT------------AAATTGGC------AAAAATTAA-----------AAAGCATG ACAATACATTCTGTATGATGAAGCTGTGGGAAAACTGGCACCTTC-ATACATTGTCGGTG GGAATACAAAGTGGTACAACCCTTCTGGAGGGAAATTTGGC--AATAC-------CTAAC AAAACTACTATGCACTTACCTTTTGACTCAGCAATCTCACCTATAGGAATCTAC------ -------------CCTAAAGATATACCCCCAACACTATGAAAATACATAT---------- ----------GCATAAGGTTAT-TCATGGTGGCATTGTTTATAATTA----CAAAATATT GG--AAACGACCTA--------------AATGTC--------------CA--ACA----- ---------TACGT----------AGAAGAATGGTTGAATAAACGATGGCACAGCCATAC AA----TGGAG---------------TACTA------------TGCAGCTGTAAAAAAGA AT-------------------------GAG-----GCAGATCTCTATGAATTGATATGGA GTGATTTCCAGGAT------ATATTG-----TTAAGTGAAAAAAGC---AAAGTGG---- ---------AAA---GGAGTGTAAGAAAGAAGGGGAGATAT---AAGAAAATATACATG- ---------------TATC----------TGCTC---------ATTTGTCA-----AAAA GAAACACAGGAAGGATAA-----ACCAGAAACTAATGAG--------------------- ------ACT--------GGTTA---------CCTATAGGGGTGGGTGA--GAATAGGGTG GAAAGAATGGGGG-----AAT-AGGAATAG-----------------------GGTAGCA GGGATG----AGGGAGGGGTTGACACTTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TGAGTATATCTTTTT----GTATAGT TCT---GACTTTTAGAACCATAGTAATGTTTCATATAC-CC------AAAAATTAAATAA ATAATTAAAATCAACCAGGATGTG---GAGAAAACTCCTAAAATGGAA------------ ------TATAAACA-AT--A---ACAAA------TGAAGTAAACCCAGTTTATTATAAAT -GAATAAT--ATAA------CTACACCG---------AAGTGGGATGAAACATAGGAAAA AAAAAAAACT---------AATCTAAGTAACTTTGGAAAACAGTATTTTGACTGTATGCT GTAA-------------------------------AGCTAAAGACAAAAAAAACTGT--- ACACAAATACTGTACTCTAGTTAGTAGATTTGTTTTTCATAGGGGTATGGGTTAGTAATT CTGAAACTATTTTATGTGTATAATAGG---------------ATTGAGCAAA-----TAA A------------------TAAATATATT-GTGGATAATGAGAGCCAGGTTTCTCACTGT CAGAGA----------------AAGAAGATACAAATAAGAAAAGGGGGAAGGCTAGAATG AACCCTGTGGTGTTGGATT-GTAATGGGTATCAGT--ATGAACTC----ATGA-TTTTAA ATACAATGTATTATATATAGTTTATACATATTA---------------TATCTAGCCATA TGTGTACATTTAAGAC--AGAT--AAA---TGGATAGAGATAATATAGATATATATGTA- --TGTGT------ATG-TGTTTCTACACAT-ACATA---TATTTCCTAGCTCTGTCCG-- CTGAGAGGG---------------------------------CCTAGAAGCAAT--GACA CCA-CAGTAGCAATGAACACACCTAGCACCCAGATTTTGGTTTCTAAATACC---ATT-- ------CTCCAATAAAAGGAA---------------------CCAGGG------CTCCTT -------------------------------------------AGAGAAATGGCTGATTC CAGGGCTGGGGCTGGGGAAAATACAAGATGAG------CCTGGAACATCT--TGTGGTAC CAGAAAGTAAGAAATTGTTAAAAAAATGTGGGAAAGAAGATTTTCACGTGTCAAAA--GG ACACAGGAAC--C------------AACTTGAAGGAGCTCCCAATGGCCAAATC------ ---TAG------------------------GAA---AATTTGAGC--ATCAA---AATAA ATA----------ATGATAGTATTGGATTATAACCCATAGAATAAAATAAATATCCATAA GTCCATA-----CTAATATAAAAACTGAATAAAAAAGGTGGGTAAATGGGGAAAAAGG-- ---------------------AAAGCTCTTCCTTACAG---------TAGAATTCCAATT AATAAA--TGGAGAAGGAATGATGGAA-------------------ATGAG--AA----- --------------ATCATCATTT---GGCAAACAT---------------CACAG---- ------T-AATAATTGTTG-----------------------CAAGCAAGAATC---ATC ---------AA--TGGATGCT-------------------AAAATTAGTGG------GTA AAAGTTTGATG-AGAAATAGGATATTTACATAGTC---TCAAA-GTATCTCCCCAAAAAT TAC----------------------TTATTAATTACAAAG---------------GGAAA ---AATA------G------TAACTTTACAGTG-GAAAAATCTGGCAGACACCA------ ----------------------CCTTAACTAA-GTGATCA---AAGTTAACATCACC--- --AGTAATA---------------AGACATACTGACATCATGTACCCCCTGATATGATGC ACTGAGAA-----GGGCACAACATCACTT-CTGTGGTATTCTTG--------------CC AAAAATGCATAATCTTAATCTAATCACGAGAAAACAATCAG------------------- ------A-------------CAAACC--------CAAA--T-TGAGG---AACATTCT-- --ACAAAATAACTGG--------CCTGTATTCTTCAAAAGTG--------T--------- ---CAAGATCATGAAA-----GCTCTA---CCACCCCCCAA-----AC------------ --------------------AAAGAAAGACTGAGG--AACTGTC-CCAGATTAAAGGAGA C--TAA---------GGAAACATGA-CAACTAAATGCAATGTGGGATCCTGGATTGGATC CTGAACTAGGAAAAA--------GACATTG---GT-GGGACAACTGGTGAAATTTTAATA TGGTCTGCAGATTAGTTAATAGTATTGTATCAATATTAAATTTCCTTGGTTTTAATAATT GTACTGTGATTATGTAAAATGTTGACCTTTCTTTCTT-AGGATCACACAGAAATATTTTA GGGTAAATGGATATCA---------TGTCTGCAACATATTCTAAAA------TTATTCAG G--ATAAA-------AAAAATA-----ATAACATAATTTTT------------------- ------TTAT-GAAGGTGTGTGTTTGGAGAGAGAG------------------------- ------------AATGAGA--------AAGCTAATGA----------------------- ----------AGTAATAA-------------AATT---ATAACATTTAGGAAATCAGGG- ------TGAATGGTATATGGCA--GTTCTTT-----------------------ATACT- -ATTT---AA---------GTTTTA---------------------TTTCTGTA-AATT- --------------TG-----------------------AA---AT-------------- --------------TATTTCAAAATAAATTATTTTC---------ACATC----TATGGA TATG------------TAATAA-TCAGATAGAAAT---------------ATTAAA---A TATTTATAT---ATTACAT-----AAGATATAAAAGAAAGT----TA------------- -----TAGAA-------------------------------------------------- ------------------------CA-------ATATAAAAGCATATGAGTGTGTATACA TACACATTC--------------------------AAAAATAAAATT------------- ------------------------------------------------------------ --------GTAAAAATGTTTATGGGA---------------------------------- ----------------------------------------------------------GA ATAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----GAAG------------------------------------------TG-------- --TTAT---GATTTCTCTAGC--------TTATTTGAAAAT------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ACTTAAA--------------------------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------AACACA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAGTAAATATGGCAAAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----ACTGATA------------------------------------------------ --------------------------------------------ATGATGGAACCAGT-- -------------------------------------------------TC--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------CA--------------------------------- ---------------------------------GTTCCTTGTATG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------TGCTAGTT--------------------------------- ----------------------------CACTGTTCTCTTCTCCTCA------------- ------------------------------------------------------------ ------------------------------------------------------------ TACACTGT-ATGTTTAC------------------------------------------- --------------------------------------------AATGTG---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TTCAT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AATGAAAAG------------------------------------------ ------ >L1ME3 ------------------------------------------------------------ ------------------------------------------------------------ ----------GGGGTGGTTCCAAG-----------------ATGGCCAAATAGGAAGAGC TCCAGTCTA---------------------------CAGCTCCTAGTGCG---------- ---------------------------------------AGCGACGCAGAAGACAA---- -----------GTGATTTCTGCATTTCCAACTGAAGTACCGGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------TTCATCTCACTGGG------GCTTGTCGGAC-------AGTGGG TGCAGGACAGTGGGTGCAGCCCACCGAGTGTGAG---------C-CAAAGCAGGGCAAGG CATTGCCTTACCCG----------GGAAGTG----------------------------- --------------------------------------------------TAAGGGGTCA GGGAATTCCCTTTCCTAGCCAAGGGAAGCTGTGA-----CA---GACGGCACCTGGAAA- TCGGGTCACTCCCACCCTAATACTGTGCTTTTC-------------------CAATGGTC TTAGCAAACTGCACACTAGGAGATTATAACCCGTGCCTG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCTCGGAGGGTCC---------------- -------------------------CACGCCCACGGAGCCTCGCTCATTGCTAGCACAGC AGTCTGAGATCAAACT-------------------------------------------- ------------------------------------------------------------ --GCAAGGTGGCAGCCAGGCTCAAGGAAGGGGC------------GCCCACCATTGCTGA GGCTTGAGTAGGTAA--------------------------------------------- ---------------------------------------ACAAAGCAGCTGGGAAGCTCG AA-------------------CTGGGTGGAGCCCACTGCAG------------------- ------------------------------------------------------------ ----CTCAAGGAGGCC-------------------------------------------- ------------------------------------------------------------ ----------------------------------------TGCCTGCCTCTGTAGACT-- ---------CCACCTCTGGGGGCAGAAAATAGTTTAGGAAAAGATATCTGAGAT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TTTTGCAGAC-------TTAAATGTCCCTGTCTGACAGCC TTGAAGAGAGTAGTGCT------------------------------------------- --------------------TCTCCCAGCATGGAG------------------------- --------------------------TTTGGGATCTGAGAACGGACAGACTGCCTCCTCA AGTGG-GT-------CCCTGACCCCCGAGTAGCCTAACT--------------------- ------------------------------------------------------------ --------------------------------------------GGGAGGCACCCCCCAG TAG-------GGGCAGACTGACACCTCATATGGCCGGGTACCCCTCTGAGATGAAACTTC C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----AGAGAAATT--------------------------------ATTAAACATCCACA TC------------TGCTATTCAGCAATATTCGCTGTTCTGCAGCCTCCTCTGC------ ------------------------------------------------------------ ------------------------------------------------------------ ----TGATACCCAGGCAAACACGGTCTGGAGTGGA----CCTCCAGCAAACTCCAACAGA CCTACAGCTGAGGGTCCTCTATAG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------ATCAAAGAATATTAATGAATTTAAAGGAAAATGTAAG CTAGATACAACCATACTGAAGCACAACAAAGAGAAGATGTTGAAAATTCAAAAAATCAGA GGATCTCTCCCCCTCCAAAGGAAAGCAGCTCCTCGCCAGCAGCCGTACAAAATTACATGG AGA-----------ATAACTCAAATATATACAGAAGAAAACTTGACATA----------- ----------------------------------------------ATGTAAGTGATCAA AATATTAAATGGAAATAATTGTTGTGTT-----------ACCATCAGAAAA--------- ---------TATAGAAACCTTAAGAAGGTA------------------------------ -GAAGGTGATTAACTATTTATAATAATCAGTGCAGAGAAGTTCTAAAAGAATCGAATG-- ------------------------------------------------------------ -------------------------------TAGATAAAGA-----CCATGGCACGAGAA CTACGTGACAAAATTTCTATATTCAGTAAAAAATTTATTTAAAACGAAG--------AAA AAAAAAAGGAGTTTGA-------------AAAT--------CATGTATATGA-------- -------AAT----GAAGC---------------------------GAG---AAGAGAAG TTTAGAG-------------TAAAAAAGGTGAAAAGAAACGGGTTGAGAGAAGA------ ------AGGC------------TTCAGATGAT----------CAAACTTCTCCAAGCT-- -AAAAGGAAGAAGTT--------------------------CAAACCCACTGC-----AA AGAAGCT---------------------------------------------AAAAATCT TGAATAAAA--------------------------------------------------- -GATTAGA----------TGAGTGGCTAACTAGA-------------------------- -------------------------------------------ATAATCAGTGCAGAGAA ----------GTCC---------------TGAAATG------ACC---------GGATG- GAGC----TGAAA---------ACCAT---GGCACGAGAACTACGTGACAAATGCACA-- ---AGCTTCAGTAGCCAA----------------TTCA--------------------AT C--AACT------------------GGAAGAAAG-GGT-ATCGG--TGCTTGAAGAT--- -CAGATGAATGAAA-T-----GAAGAGAGAAA---------AGAACAAAAAA---ATAAA AAGA---AAAAAAAGA-AA---------TAAC--ACAAAGC------AACAAATATGGG- ACTAT--------G---TGAAAAG--GCCAAATCTACGT--C-TGATTGG--TGTA---- ----------CCTGAAAGTGACGGGGAGAATGGA---ACCAACATGA---------AAAA CAATCTG----------AAAGATAATGACCAGGAAAAATTCCCCAACCT----------- ---------AGCAAGGCAGGC--CAAC--ATTCAAATTC-----AGGAAATACAGAGA-A TGCCACAAA------------GATACTC-CTC--------------GAGAAGAGCAACTC C-------A---------------------AGATACATAATTGTCAGATT------CAC- CAAAGTTGAAA---TGAAGG--AAAAAATGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGTCGGGT-------------- -----------TAC---CCACAAAGG-GAAGCCCA--------------TCAGACT--AG CAGCAGATCTC-----TCGGCAGG---ACTCTA-CAAAC------CAA-AAGAAAGTG-- -----------GAAGACAAATA-T-------TCAAAA--TGCT-------------GAAA GAAAA---------------AAATAT--CAA--AAACAGAA--------TTC---CATAT CCA-----------GCCAAACTAAGT-----TTCAT-AGGTGA-------AG-------- ------------------------G-AGAAATAAAATCCTTTACAGGCAAGC-AAATGCT GAGAGA-TTTTGTCACCACCAGGC---CTGCCCTAG-AAGAG------------------ --------------------CTCCTAAAGGA----------------------------- -----------------------------------AGCAC--------------TAAACA TGG----------------------------------------------------AAAGG AACA---------------ACCGATA---------------------------------- -------------------------------CCATCCACTGCA----------------- ------------------------------------AAAACAT----------------- --------GCCAAATTGATAACTGACAAAACAGTACA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCATCAAACC-------------------------AAGGA C-------------------------------------------------AAAGCTGCAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CAACTAATAAGGA--------------GA---ATAACCA ACAAA------------------------------------------------------- ------------------------------------------------------------ -------------TAGCAATATGAAAGAATAAAATCCAATCA------------------ ------------------TAACA---ATATAGTGCAAAT--------------------- ------------------------------------------------------------ --------------------TCTACTTTA--TCAGTAATTAC-ATTAAAT-------G-T AAAT--GAATTAAAAATAC---TCCAATC----------------AGAAGGC------AA AGAG--CGACAG----AGTG---------ATTATTTTTTAAAA---------GATCCAA- ---CCA-------GAT-GTAATCTA-CAAAAAATCTATATTAGCATCAGCAAAAAAATCT T-TCACTTTGAAATACAA------T------------GGAAA----A-ACATGTACCATA C--------------AAACAG------TAACC---------------------ACAGGGT AAGAAG---TAT----TGCTGTACTAATAGC-AGACAAGATAGATAATGAAACTTTAGAT TTTTTAAGATCT---TCCATAGATAATAAAA-AGGAACAT------TTTAT------AAT GATAAAA--AGGTTCAAAA------AATTAG---GAAG--------AT-ATGACAA-TTA TAAATGGAGGACACCTGTAAA----TATATATG---------CTAACAATAACATAATTT CAAA--ACA-TAGAAAACAAAAATTGAAAGAAAT--GA----AAGAAGA---------AA TAGACAACTCCAGGATTATATTTATAGTTGGAGATTTTAATA----------------TA TATCC------CTCAGA-AACTGATAAAAAAA---------------------ATGACT- -----AGAA-------------AATCACTAATACTATAGAAGATTTAAAC-ATAAAGATT AA------CTGACTTG---AATTAATTGACATATATA--GAAG--GCTCTATATCCAACA AG---TACAGCATATAAAT------CCTCCTAATATGGAGGTAAGCCAT-GGAACGTTAC CACAGCATAAAATAGACCATGTATCAGGCAAGAAAGCAAGGGGCACATCATATTTTAATG ATTTAAATCAATCTAAAAGGA--TTAAATT----------------CATACAAA------ -GTATGTTATTT---GACCTCCGTAGAA-TTAAATTAAAAATCAAG-------------- ----------------------------------------------AACAGAAAGATAAA --------------AGGAAATACTAA---AAAATCATCGC----ATGATTGCAAA--T-T AACCAACAAA-TTCTTCAA---TA-ACTCATT--AGTTAAAGAAAATAAAA--TCACAAA GAGAATT---------------AATAAATGCTTT---AAGAT------------------ ------GAATGATAAAA--AAA------------TAGAGC--ATGTGACAATTTA-TAAG GAT----TGCAACCAAGCCATGG-----------------------------CTTAGAGG AAAA--GTTATAGCTTGA----AATGC----ATATACTGGAAAAGAAAATTTAAAAGTCA TATCAATAAAG-GATCTTG-GCCTTTAGCT----AAGAAG---AAGAAAAAT------AA CA-----GCAAATTAAATCCACAGACTAACACCAAAAT--AGATGGAA-TCAAAGAAATA ATA---AAAATAAAA-------------------ACAGAAATA---AA-G-GAAATTTAA CATAC------AA------------------------------------ATA-TAA---T AGAAAAAAATCA---------ATACAGCAAACAG-AAATTTA-----GATTCTTTGAAAA GATTAA------------------------------------------------------ --------------------------------TAA-----AATTAACAAATCAT--CTAC CAT------GACTAATTCAACAAGAAAAATAAAGAAA------------------AAACA AGGAGAGA-AGATAC-----------------AAATAGC--------AAGAA-----TG- ---------AGA-ATTAATA--GA----------GGTGT-----CCACTACAGATCCT-T TA-AACAT---TTAAAAATAAATGAGT--------GTAGTATT--TTTAA---------- -----------TAA---CTTTATCATAATAA---ATTTGAAAATTTTT---ATGACGT-- TAGCAGATCCTT--------TGGAAAAAA---------TAA-----ATAACATAAAAATA GAAACCAGAAAA---AAAAAAAATAGAAAATATGAACAATCTATGTCTTTAAATAAATTG AATCC------------AA-TAATTAATAACGAAATTGAAC-T---------TTTCAT-- -ATTAAAACTTCC------CACAAAGAAAAC---TTCAGGCTC--AAATGT--------- ------------TTTCAAA-GGTG--AA-------------------TTC---------- ----TCAAAAATTT---GTGAGA-GAGATAA--TA-TTAATC-----CATGCATGAACAA AATTTT----GC---AGAGAATAGAA------AACAAA-GG-----------AACATTTC CAAACACATTTT-----ACAAGACC-----AGCAG---AAGCTTG-ATAT---------- ----------------------------------------C--AAAAC-------CATAC AAG---------------------GAC---ATTTCACTGAA---GGAAAATTAC------ -------------T-GGGCAATAT---CTC----TCATGAATATGTATATGTTTATATAT ATATACACACACGCAAGAATAC-TAA--------------------A----TAAAATACT AGC-AAATGG------------------AA--TC--------------CA--GTT----- --------ACATATA---------AAATGAATTATAAA--AAGTGAT------------C AAG---TGAGA-TT----------TATCCTA------------GGAAAAAAAAAGGAATG -TATTTCATCAAATACAGTTTATTTAAAAT-----ATATTAAAAAACAAATGAA--TGTA ---ATTCACCGTATTACATTTAACAG----AATAAATGACAAAAAT---AAAATGA---- -TTATTTCCATA---GATAT----AAAAAAGTAATTCATAA---ATTTAAAAAAACCTT- --------------TCTTGA---------TTAAAAAAAACAACAATTCTCAAC---AAAT CAGGAATAGAAGGGAACT-----TTTTCAATCTGATAAA--------------------- ------GAACATGTTA-TAAAAA------CTCCCACAGA-----------TAACAT--CA TACTTAATGATGA-----AGT-TTTGGAAGCT---ATTT---TCC----TT--ATGATTG GGTATA----AAACGTGG-ATGAGCAAAGTA----------------------------- ------------------------------------------------------------ ----------------------------------CCACCATTCCAATCC---AACATTAT ACA---GAAGCCCCTAG------AAAT--------TAGCAT------------------- --AATAATAGGC---------GAG---AGAGAG------GAAAACAAG------------ ---------------AT------GCAAG-------------------------------- -GTAAAAC------------ATTCTTCA-------------------------AACGGTC TACTATAAAC---------AACAAATGCGAACTTAATGAGG--TTC-----CTGGAAAC- --GA-------------------------------AGTCAG---------------T--- ACAAAAATAATACATT-------------------------------------------- -----TTAATTTC--CA-TGTATCAGC---------------AAGACAGGGG-------- -------------------GAACGAAATATAGA----AACAAAACACCATTTACAGCAGC ATTTA-----------------AAAAACATC---------AAA------TACTTAGAAAT GAGTGT--------AA--T-GAAATATGCG---C---AAGATTCAT---ACGC-TATAAA CTGCAAAATGT------TCTTG-AGAGAAATTA---------------AAGG-------- ------------ACACCCAAAT--GAA---TGCA---GGGAACTGT---------ATAA- --CGTTC------ATG-GATTGGGATAAGATA--------ACT--------------G-- TATAAATG-----------------------------------------TCTCTTTTCTC TCC-AA--ATTTATCTATA-------------------GA---TTCAATGAA---ATA-- ------G-AAATTAAATTGAAGAACAAACCTCTGGTTTGTTGTTGTTG------TTTCTT ------------------------------------------TGAGGAGATTA------- ----------------------ACATTCTTTT------TCTAAAA---TTTATATGGAAA T-------ACAAAGATCCAC---TA--ATGGCCAAGGCTATGTTTAA-----------GT TCA---AAGC--T-------AGA--GGTCACATG---CTACCAGATAATAAGGC-----T TTCTGT-------------------------AATCGAGATTCAG--AATTTA---AGG-A GTATT------------TGGTATTGA-------------------------CAAATA--- ------AGAT--CA---ATGG-GATAGACTTGAGGGTCC------AG---AAAGAAAT-- -CCAC----------------TCA-------CGTAAGT----TAATCTAGGATTTTTTAA GACAAA--AGCATGATTGCAATTC--A-------------------GTTGA--GA---AC GT------------ATGGTCTTCT--CAATTAATCG---------------TATTG---- --------AATGACACTAGGATATTAT---------------TATTT-AAAAAA------ ------------------------------------------------TTA------ACA AAAT-TTAATT-TGGGATGG---AT---CATAGAC---TTAAAGGTAATAAAACTTAAAC TTT-----------------------CCAAACTTCTAAAG---------------AAACA ----------------------------------AAAAAAACTAGGGGAATTAA--GGT- ----------------------TTATAATTAAAGATAGAA---AGAGGAATTTCATA--- --AATAGAACTGAGAAAGCATTTTGCATAAG--GATGC----------TTGACTTAAGAA AAAAAAAC-----A------------CTT-TCACA-------CA--------------TC ---AAAATATCAT-------------AAAGTAAGTGAAAAG------------------- ------T-------------CAGTCC------ACAGAC--T-GGGAT---AAGATATTT- --GTAATATATTTAT--------AT-------GATAATGGAC--------TC--ATATC- ---CATAAAATATATA-GA--ACTATT---TCA------AATTTCAAT------------ ---AAT--------------AAAAAGAGA---GAG--AACTCAA-TTTA---AAAATGGG C--AAA---------AGT--CTTCA---AT---AAAGGATT------------------- -----TACGAAGGAG--------AATATCA---AA-ATACCCGTT---AACATATAACAA GTT----------GTTAAACATAATTA-TTCATCA------------------------- -----GACA-AGTAAGAAAT---------------TTAAAAATAACA-------AT---- ----GA---GATACCA---------ATT-----AATCCTACCACAATAGC---------- ---AAAAA-------TTTGGAAGACTGACAACA---CC---------------------- -----------AAGAATGCA----------GAACG------------------------- ------------ATGAGAACTCTCAT-GCGTTTCTGA--TGTG----------------- -----------------A-------------GACG---AGTACATGAAAGCGTTATGAAG AAACCTAAGATAGTA--------------CCT--ACAGAGCTAAAC--ATTAGCATAAC- -CTAC---AA--ACCAATAATTCTA---------------------CTCTTGAG-TATAC GA------------TG-CCCGACAAAT--------------------------------- --------------GATTTTGACCATGAAAATACAA-GATGTACAACATACAAGAATGTT CATA--CCAGCTTTATTTGTAA-TAAGCCCCAAATAGGGAAAAAGTCA-----------A TATTCATCA---ATGGTAG-----AATGGT-------AAAT----TG------------- -----TGGTA-------------------------------------------------- ------------------------TAGTC----ATACAATGGAATAA------GCACACA GTAATAA----------------------------------------------------- ------------------------------------------------------------ --------GTATTA-------------CAGTTTGATTTCACCCATTTATATGA------- ---------------------------------------------------ATTTCA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------------------------- ---TATGCAAAATTAACATAT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------GTGATGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAG--------TCAGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTGGTT-----------------------------------------------A CCT-------CAGGTATGGG--------TGGTGATTCCTTGGAAGAGGTTAGGGTAAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TTTCCTGGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ATGGAAATG------------------------------ ---------------TTCTATATCTTGATCCATGTGCTGATTACAAAG------------ ------------------------------------------------------------ ------------------------------------------------------------ -ACATAAT-ACGTATGT------------------------------------------- ---------------------------------------------ACATA---------- -------GAAATTCACCAAGCTATACCCTTAAGATTTGT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GTACTTTAC------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TACATG--TATT CTTCACTTCAATAAAATTTAT--------------------------------------- ------ >L1ME3E ------------------------------------------------------------ ------------------------------------------------------------ -----------TTCTGTTTTCAAGAT---------------ACAGCAGGCAAGAAATACT TCAAAACCT------------------------------TTCTGATATAAAA-------- ----------------------------------CGTTTAAAAGCTGAATGAGGTG---- -TAAGAGATCTGTTTACATGTATTTTCAGGTTAGAAATGTGGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------TACAGGT----TCTGAGATGCTAA------AATTGACAAGA-------AAGC-- ------------------TCTAATACAAAGAGGT---------A-GCTAGCCTTAAAGTT GGTGGGCTTATTTT----------ATAATTA----------------------------- --------------------------------------------------TCTGACTATT TCTGGATGTTCAGACTGTT----------------------------------------- ----------------------------------------------------TGGTTTAT TTGGTTGCTTATAGGGAAGAAAAAACAAATGTAATTCCCATGCAATC------------- ---------------------------------------------TAGGATATATGAGCA AAAAATTTTTTCAAAGAGTATATTTTATAAGGCAAAACC--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----CTCAGTAAAGGACTGAAATAGCATATA-------------GCCCATCATAGTCTT CACT-------------------------------------------------------- --------------------------------ATAG---TTGCAGGGACCAGTAACCTCT GA-------------------GAA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------ATCTTAATCT-------CAAGACAGTT------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CTCATATGAATAGGGGGGCAG GGGAGGGGGGTCAA--------------------------------AATAGATACTTGCT TT------------GT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GACTACAAA-----------TGACCAAATGAAAATTT TAGTTTAAAATTCTC--------------------------------------------- ----------------CTGGTTTGGTGGAACCCCTAGGCACCTAACA------------- --A-----------GTGGAAGTGCATGTTATCTCTGGAAAAATGCACTTAGTAA------ ----------------------------------------------CCATGACTCAAATA ---------------------------------------GTTCTCATAGAA--------- ---------G-------------------------------------------------- -AAATGTCA-------------------AAAA---------------------------- ------------------------------------------------------------ -----------------------------------CATAAA-----TCATGATAAAAT-- ----------------------------------------ATGATAATG--------CAA AATACATGAGGAAACA-------------AGTT--TTTA--TAAG---ACTC-------- -------AGC----AGAAGCA----------------------AC-AAG---GAGTAAAA TTAGACC----CACTATATCTGGAAAAATATGAATCCCCTCAACTACAAGATAA------ ------GTAA---------------------------GCTCAATATGTTTTAAAAAGT-- --AAAGAAGAACATC-------------------------------------------AA AAGAATA----------------------------------------------------- -----AGGA--------------------------------------------------- -CAATAGA----------TTATATAAAATAACAA-------------------------- ---------------------------------------------AGTAGATTTAAGAAT ----------AAGT---------------CAAATAG------AAC---------TTCTAA GAAT----AGAAA---------AATAT---AACAATTTAAATTAGAAATACAATGAAT-- ---GGATTAAGTATCAAA----------------TTAG--------------------AA A--TAGC------------------TAAAGAGAG-AAT-TAGTG--AACTGAAAAAT--- -AGATCTAAAGAAA-T-----TATCCAGATGC------------AATATAGA---TAGGA AAGA-----------G-AA---------TAA---ACAAAGGCAAA--TAGAAATAGAAG- ATAGA--------G---AACAGAG--GTTTAACATAT----T-TAACGGG--AATT---- ----------CCAGAAAGGAAAAAATAGAAAGAATGAAGGAA--------------AAAC AATATTT---AAA----GTAGATAATGGTT--GAGAATTTCCAGAATT------------ ---------GATGAAAAACAT--CAAT--TCTCAGATTC-----CGGAAGCCCAATAA-A TCCCAAACAGGATAAATAAAAATTTTTCTTACGCGACACTCTAAAAAAAAAAAGCGACAC CTAAAAAAAAAATAAAAAATTTATCTAAGTGGACACACTATAATCAAATA---------- AAAGACAGAAA---GAAAAGATAGATAGTCA----------------------------- -------------TTAAAGC--TGGTAAAAA---AAAGAGAAAAGA-------------- -------GAATTAC---ATATAGA-G-AACGATAA--------------TTAGATT--TA TAGCTGACTTC-----TCAATAGTAGTAATTTG-GAAGC------CAA-AAGACTATA-- -----------AAA-TAATATA-TAATAAGGTCAAAAACTATCTC-----------CAGA GGATATATATAGTGAATTT-ACTATTTTTTATAGTTAATGA--------------AATAT CCAGA---------GCAATATCATCT-----TTCTA-ATGTGA-------GA-------- ------------------------ATGAAGACACATGTGTTTTCAGACAAAT-AAAAATT AAAGTG--TTTACCACCAATAGAT---CTCCAACTA-AAGAAAATTTTCCCAAATGTGTA CTTCAGAAAAATAAAAAATGATCTAGAAGGA----------------------------- -----------------------------------AGGTC-------------TGAGATG TAA----------------------------------------------------GAAGG TATAAGGAAAACAAAGATAATTGGTAAATATG---------------------------- -------------------------------TGGTTAAATATA----------------- ------------------------------------AACACAC----------------- --------ATTGATTTGATAAAACATTGATTATGATAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ATGTCTAATTTGTGAATTAAAAAAACCAAAAAAAAAT-------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------AGAAGTAAAACATCAAAAAATAATGGTATATATGTCATTT TAAGTAGAGGTAATGGAA------------------------------------------ ------------------------------------------------------------ --------------------ATAAATCAGGTCAAATTGTTCTAAAGTTATCGTATTGTTT TGGAGAAGGGTA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AA-------- -------------------------------------------------------TATAG TGATTAACTTTTTATTTTATTAGATTAAGTTTGCATGTT-----------GTAATTTCTA GGGAAGCCAC-TTCTT-------------------------------------------- -----------CTGCCCCCAGAAACAGATAGA---------------------------- ------------------------------------------------------------ --------------------------------------------------AACAAAGGTA GTATCTTATTTCTATT-TACTTGAGGAAATTATTAGAAGGGAGAGAGAAAAATGGAGTCT GTATAAAAACAATTTAAAAAAAGAAAGAAAGAGTTAA----------------------- ---------------------AAAAGAAGAATTA--------------AA---ACAAATG TAAAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------TGGAA-----AACACATAAAT--------------------- ------------------------------------------------------------ --------------------CCAAATATA--TTAATAATCACAATCAAAT-------A-A AAATAAAAATC--AAACTT-------GAT----------------AAAAGTG------AA AGAT--TATCAG----ACTG---------GATTT-----TAAA---ATTTAAAATCTAG- ---ATA-------TAT-TTTGTTTA-TAATATTTATACTT-AAAAT--ATAAGGATATAG A-AAATTTGAAAATAAAAGAA---T------------GAAAA----AGAAATATACTAGA C--------------AAATAG------TAACA---------------------GAAAA-- --------GCTTATATACTTATATAAATACC-ATCCAAAATAGACTTTAATGTCTTTTTC CTTAAAAAATAT---TTATCAACTAT-AAAA-AGAGTCAC------TACATAGCTGAAAT AATAAA---ATGTTCAATTAA----GACCAG---GGAT--------AT-ATAAAAAGTTC TAA-----------------AATCGTATATTTG---------CATAAAATA-------AC CATAACATA-TTTAACAGAAATGTTGATAAAAGT--AA----AGATGAT---------TA AAGAAAAATCC------ACTATCATGGTGAGAAGATGAAACA----------------TT TTAAC--AAATTTTAGA-AATTAATAGATCAAACAAA----------------CAAAAC- -----GTAG-------------AGTGAGTAAAAATATAAAATATTTGAAT-AATATAATT AAATTTTTCAAAATGTAGATGTTAATAATTAAATATA--AAAGCCACATTCTTTT----- -----AATAGAAAATACAA-----------CAAAGCA-----CA--TGT-AGAACATTTA --T----AAAAACTGATGACGTATTAGGCTATAAAGCAAG-------------------- -TCTTAACAAATTTCAAAGAATCTTGATAA----------------CATATAGA------ -TCATATTATCT---AACTAAA--GACATTTTAATTAAGTGTTTTT-------------- ----------------------------------------------ATTC--------AG --------------AGATAATACTTAAAAAAACTAGACAAAATCATGTGTGGAAT--T-T AAAAAACACATCTATTAAA---TA-ACCCATG--GGTCAAAAAAAA--AAA--TCATAAT ACAAATA---------------AAAATATCTTTA---GAACT------------------ ------AAATAATAATGA-AAA------------TACTAA--ATATCAAAACTTG-TAAG CA-----TGCAGCTAAATTAGTA-----------------------------CTTGGAGG GAAA--TTTAAAGTCTTA----AATGT----GTACTTTAGAAAAGTTTTTAAAAGGCTG- --AAAATTAAT-AATCTCA-GCATACCATTT---AAGAAAT--TAAAAAAAGTTT---AT TA-----ATTGAATAAAC-------------TCAAGAA--AAGTAGAA-GAAAATAATAT ATA---AAAATAAAA-------------------ACAAATCAG------T-ATAATGGAA AAC--------AA------------------------------------AAA-TTG---T AAAGAGAATC-A---------ATA----AAGCCA-AAAGATG------GTTCTTTGTAAA GACTAATTGATTTTTAAAAAATTGCTTCTCAGCCTTTTGGCTAAGATCAAGTGATAAAAA ATTATGATCAAGATTAAAATTATGATTAAGATCAA-----GACTGATAAAACT---GTGG CAA------TAATAA--TTG------------AGGAG------------------TAA-- ----GAGAAGGATAG-----------------AAATAAA--------TAATA-----TAT ATTAGGGAGAGA-AATAAAAATAAAAAGTATTATGGAAAGTATATAACTACAAATGGG-G CA-GAGATT--TAAAAGAA-AATAAG---------AAAATATT--ATGAA---------- -----------CCAA--CTTTATGACAATAT---AATTTAAAACTTAG---ATGAAATAA GCAAAAATTGCT----------AAAAAAA---------TAT-----AAATTAAAA----- -AAATCAATTCA---AGAAGAAATAGAAAACTAATAT----------------------- GGTCT------------TA-TAATCATTAAATAAATTGAAT-C---------AATAGTTT -AAAAATCTTTCC------CTTAAAGAAAAC---ATGATGACC--AGAAAG--------- ------------TTTTACATAGTA--AG-------------------TTCTG-------- ----CCAAACATTG---AAAGAA-AAGATAA--TT-TCAATCATACACAAAATTACACAA ACTCTT----TC---AGAGAATAGGA------AAAGGG-AT-----------AATATTTC ATAATTC-TTTT-----TTGAGGCT-----AGTA----CACCTTTCATGC---------- ----------------------------------------T--AAAAC------ACAG-- AAG---------------------GAG---AGAAAAGAAAA---GACAAATTAC------ -------------A-GGCCAATTT---TAC----TTATAAATATAGAT------------ ------------ACAAAAATTC-TTT--------------------A----GAAAATATT AAC-AAACTG------------------AATAGCTGAACACACATACGCA-TACACACAC ACATTCATGTATATCCATGTATATAAAAAAATAACACATTTCATTAA------------C AAA---TTTGA-TT----------TATCTCA------------GG--AATGCAAGTTTGG -T----------------------TT-AAC-----ATTAGA--AAATAGATTAA--TATA ---ATTCACTACAT------TAATAG----AAGAAAGGAAAAAACA---CATATGA---- -TTATTTCAATG---GATGCAGAAAAGAAATCACTTGATAA---AATTCAACATCCATT- ---------------CATGATTTAAAAATA---A--AA-----GGTTTTCAGC---AAAT AAAAAATAAAATTTAAGT-----TTTTTTATCTGATAAA--------------------- ------AAATAACTACAAAAAAG--------TCTGCAGC-----------AAATAT--CA TACTTAATGATGA-----AAA--------------------------------AAG---- GGAAGA----AGA-AAGT-ATGT--ATGCAG----------------------------- ------------------------------------------------------------ ----------------------------------TTATTACTTTT-TTC---TATACTAT CCA---TGATGACCTAGCCATTGCAGT--------AAT-GC------AATTT---AAAGA --CATTACATGTGTAAAAATTAG----AAAAAA------AGGGCAAAA------------ ---------------TT-----------------TTAG--------AATTGTATTCATA- -GTAAAAT--T-AAAGAAAGATACAGAT---------A---------------GATCAAT TATTAGAATT---------AA--GAAGATATATTAGCAAGT--TTG-----CTAGATAT- --GA-------------------------------AATCAA-------------CAT--- ----AAAA----TAAT-------------------------------------------- -----TGCTATTC--TA-TATGTCAGC---------------AACAAACAGA-----AAA A------------------TAAAACAATTTTAA----AATATAA---CATTT-------- ----------------------AGAAATATC---------AAG------TAACTAAAAAT AAAACT--------AT--C-ATAATATATG---C---AATAATTAG--------GGAGAA AACGGAAGCTT------TATTG-AAAAAAA------------------------------ ------------ACCCTTAAAT--TAA---TGAA---GA--GATAT------------A- --TTGTC------ATG-AGTCAGAGCACTT-A---A---CATT--------------G-- -TAAAATA------------------------------------------------TCTC TCC-AA--ATTGATCTATA-------------------GA---TTCAACCTG---ATT-- ------C-CTGT-GAAGT--G---------------------CGAAGG-GT---TTTCTT TTGTTATTGTTGCTGTTGCTGCTGTTTTCTTCCCCCAACCCCCGTGGAACTTG------- ----------------------ACAGACTACAATTAGTTCTAAAA---TGAATATATAAA T-------TCAAATTATCAA---AA--ATAATAAAAGCATTTTTA-------AAAA--GA A-----AGGG----------GGG--GGACTAGCT---CTATAAAAGATTAACAT-----T TGCTAT-------------------------AA---AGCTATAGA-AATGAA---GAC-A ATG--------------TGATATTGG--CA------------C---AGAGATAAACC--- ---ATTTGAT-------GTTGAAACAGGA-AGAGAACCC------TG---GAATAGAG-- -AAAC----------------ACA-------CATATGA----ACACTA--GACATGT--- GATAGA--GGTAGTATTGCAGTTC--A-------------------GTGGG--TA---AA GG------------GTGGATGTTT--TGCTACTTAT---------------TACTG---- ------A-TATATT--TAA-TTATCCA---------------TATGG-TTAAAA---ATG ---------AAGCTGGAGTCC---TTCCT-----------CATACCAAATA------ATG AA---CCAATT-CCAGGTGG--------TCTAAAT---GTAAAAATG--AAAGACAACAT TAT-------------------------AAACATTTGTAA---------------GAAAA AATAGTAAACTATG-------TCTGTTCTCCCACAGAGATATTCCCAGAGATTG------ --------AGAATGATT-----TCTT-----------------GAAATATATATAAT--- ------------AA----AAT---AGATAAA-TTCCAC----------AAAATTAAA--- ATTTAAAAATGAGG------------TTTATTGAGGGA----GA--------------TT -AAAGAAAATAAT-------------TGAGAAAA-ATAAAG------------------- ------A-------------CAAGCC------ACAGCA----GGG-----AAGATGGCT- --GCTGCACAAATAA--------TC-------AACATGGCAT--------GC--TTACC- ---CAGAACACATAAA-GA--AATTCC---ATG------AT--TAAGT------------ ---AAG------------------AAAAA---GAC--AACTAAA-TAAA---AA------ ---AAA---------------------------AGAAATTT------------------- -----CACAGAAAAG--------GAAACAT---AA-GTGGCCTAT--ACACATGTGAAA- ----------------------------GTTATTA------------------------- -----CAAA-AATTTCAA-----------------CT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------CGGA-GCAGTTGAG----------GAGCA------------------------- ------------GTGGACACTTTTGT-CCTCTGCTGCTTTGTG----------------- ------------TGT--A-------------AATT---GCTTC----CACCACTTTGA-- ------AAAACAGGCA-TGGTATAG------T--AAATTATAAAAAGTGCACAATCAAA- --------GA--TTCAGCAATTTCA---------------------CTTCTAAGACATA- --------------TA-CTCTGGAAAA------------AA---CTTT----TACAAATG TGTACCAACAGAGGTGTATAAA--AAACATAGCAGTGATAGTACAACACT----GGAATT AATT--GCAGCA-TATTCATGCATAGTAATATTGT-----------CA-----------A TGTA--------ATAAA-------AATGAATTAACTACAACTGCATG------------- -----TAACA-------------------------------------------------- ------------------------TAAAT----GTAATGTTTAGCAC-----AAAATTCA AACAACAAGATAAT---------------------AAACATAATATAATTCCATTTGGGT AAATTTCAAAACATATAAAA---------------------------------------- -------TAAAACAATATGTTTTTGG-----GGGAATCTATAAAATTAGGTAA------- ------------------------------------------------AATACTTTTAGA AAAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AACA-----------------------------------AAATGA-TG-------- ----AT---GATTTTTACTAT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGG--------GTATGAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AAGGGAT------------------------------------------------ ----------GGGGCCTAAG------------------------GGGGCCCAAAGATG-- -------------------------------------------------GC--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TAAATCTGCTGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------GAGAACACCTGAGTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------TTTTGTCTTTTTGTCTCCTCTACCTAGGCATA------------- ------------------------------------------------------------ ------------------------------------------------------------ -TAAGTGT-TCATCTGG------------------------------------------- --------------------------------------------AA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GTGTTTAAT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AATTAATAAAAAACTAT-------------------------------------- ------ >L1ME3B ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TGGGGTAGAGAATAAAAGT TGGAGTCCA--------------------------GACCCACTCAAGGGTGT-------- ----------------------------------GGGTTGCTGCCTGGTAAAACCTCCAT GCCTGACACTGGGATCCCCAAGGTTTGCATCCTAGACATAAGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------GTAAACTGAAATTATAACAG----------TCCTTGCAGACACTGTAGCCTAGC TTCAAGTCATCTGAATGGTCCAGAAAACTGTAAT---------CCCTAAAACTGGATTAA AGTAATCCCAGATT----------GCTAGTG----------------------------- ------------------------------------------------------------ -----CTTTAGGACCTGGCAGAAAAAAAATGAAA-----AT---ATTCTTTGGAGGAAAG TAACGTCATCCTAGGCCTC---------------------------------AAAATATT TTTACAAATAATTTTTCAAATACTATGTCTGACACAC----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AATCAAAGGTAAC----CAGGCACAAAAG GAGA-------------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------CAAGACAATGTAA ATGAAAACTAGTAAAAACAACAGAAAACAGAA-------------ACCCTCAATGACTCC AGATATTGTGGCTATCAGA-------------------------------------CAGA CTTAAAATAACCATG------------CTGAAGGAG---ACAGGAAGACATAGTTGAATT AG-------------------CGGACTGGAAGTTAGGTCAG------------------- ------------------------------------------------------------ ----AAGAAAAA------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TCC-- ---------AGAATCAAGCAGGAAGAAACAAACAAAAATGGAAAAATTCATAAA------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AGAAGGTAAAAGAAGG CCGGGCACTGAGGCGGACAAGACGCCAATATAAAGA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CACCCCATCTAATACGAATAC CAGGAAGGAGAGAG--------------------------------ATCCTATA------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAAGAAATA-----------TTGAAGAGATAATGGCA G----------------------------------------------------------- --------------------------AGCATTTTTAAAAACCAGTTA------------- --A-----------AGATATTAACCTACTGATTTAAGAAA-------------------- ----------------------------------------------GCCTACAACCCCTA AGAAAGATAAATAAAAAGAAGTCTATACCTAGACACACAACTGCTAAAAAC--------- ---------TAAAGGCGGGA---------------------------------------- -AGAGAAAATCTTAAAAGCAGTCAGAAAAAAAAAATTACCTGCAAAAAA----------- ------------------------------------------------------------ -------------------------------TGGGGAGAAA-----CCACAGCAGAAAGG CTG-------------------------------------AAAATTCCA--------AAA ACCA----GAACGCCT-------------CTTC--TCCT--CCAA---A-GG-------- -------AAA----ACAACTCCTC-------------------GC-CAG---CAAGGGAA CAAAATT----AAG-----ATGGAGA---ATGAGTTTGATGAGTTGACAGAAGT------ ------AGGC------------TTCAGAAGGTCAGT-AATAACGAACTTCTCTGAGCT-- --AAAGGAGCATGTT--------------------------CTAACCCGTCGC-----AA GGAAGTT---------------------------------------------AAATCCTT G-AAAAACA--------------------------------------------------- -GGTTAGA----------CGAACGGCTAACTAGA-------------------------- -------------------------------------------ATAGCCAGTGTAGAGAA ----------GAAC---------------TTAAATG------ACC---------TGATG- GAGC----TGAAA---------ACCAC---AGTACGAGAATTTAGTGAAGCATACACA-- ---AACTTCAATAGCCAA----------------TTCG--------------------AT C--AACC------------------GGAAGAAAG-GAT-ATCAG--TGATTGAAGAT--- -GAACTCAATGAAA-T-----AAAACAAGGAG---------ACAAGATTAGA---GAAAA AGGA---GTGAAAAGA-AA---------TGA---ACAAAGCCTCC--AACATACATATA- ATTGG--------G---TGAACAG--GCCAAATCTACAG--T-TGATTGG--TGTA---- ----------CCGGAAAATGACCGGGAGAATGGA---ACCAAGTTAG---------AAAA CACTCTT---CA-----GGATATTATCCAG--GAGAACCATCCCAGAAA----------- ---------AAGAGGAAAGGA--AAAC--ATAAAAATAG-----AATCAACATACAGA-A TAGTGCAAA------------AAATTTT-TTT---------GAATATAAGTAAAAGACAC C-------A---------------------AGCTACACATTTGGCAAG------------ CATATTCGAGA-----AAGA--AAAAAATGT----------------------------- -------------TAAGGGT--AGCCAGAGA---GAAAGGTCAGGT-------------- -----------TTCAAACTAACAGGC-AGGTTCAAGAAAT---------TCACACT---- TAG-AAATATG-----ATAATAAAA--GTACAG-AAAAC------CA--AAGACA----- -----------AAGAAAAAGTA-G-------TCAAAC--TAAC-------------CAGA AAAAA---------------AGAGTT--TCA--ATCCAGAA--------TAG---TCTAC AAA-----------GAGTAACTTACA-----TTCGT-AAGTCACTTCTATAT-------- ------------------------G-AAAAATGGA---------AGCCAAAGACAGTGGT ATGACACATTCCTAGTGGTGAAAG---AAGCCTCAC-AGGAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCAC--------------CAAACA TGG----------------------------------------------------ATAGG AACA---------------ACTGGTA---------------------------------- -------------------------------CCAGCCACTGCA----------------- ------------------------------------AAAGCAT----------------- --------GCCAAATTGGGGCAGACAGAAAATGACCCC---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------AGAAGAAAAGTTAGAGATGCAGG AAAAAATAAA-------------------------------------------------- ------------AGGCAATGAAAAGTGAGTATAAATGAATACTGACCGCATAAAACATAA TAATGATGTGTTGGATTTAAAATTACAGATAATTAAAATACACAACAACAACAGCAACTA AATAATATCATAGCTAAAGCA--------------------------------------- ------------------------------------------------------------ ----------------------TATTAAAGTCCCTGAATTATCTGGGAAAAAAATAAAAG TACCAATTAACA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CTTTGATAGA-------------------------TCAAA AATCTATGTTGTAATCTTTAGG----------------------------TTAATTACTA AAAGAATAGT-AATACAGGAATATATATCTTCTAAAC----------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------TAAAAGAAAA AAAAAATGGAATAATA-AAAAGTAGTTTAACAAAGCAAAAAATGACAAAAAAGGCAGGAA AAGTGAGAAAAAGGAACATATATCAGCTG------------------------------- ---------------------GGACAAATAAAAA-------------------GCACATA GTAAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ATAGTGGATTTTTTAT-------------- ------------------------------------------------------------ --------------------CCAAATATA--TCAGTAATTAT-AATAAAT-------G-C AAAG--AGATT--AAATGC---TCCAGTT----------------AATAATC------AA AGAT--TGTCAG----ACTG---------GATTTTTATTAAAA-------------CAA- ---CTA-------TCT-GTTGTTTA-CAAAAGACATGCCT-AAAAC--ACAAGGATACAG A-AAGTTTGAAAATAAAAGAA---T------------GGACC----A-AGGTATTCCATG G--------------AAACAG------TAAAC---------------------TAAAG-A AAGCTG--GTGA----GGCTATATTAATAAA-GACTAAAATAAACTTTAAG-GC------ ----AAAAAAAGTA-TTAGTAGAGTTAAAAACAGGGACAC------TTCGT------AAT GATAAA---TGTTTTAGTT------TAATAAAA-GATG--------AA-ATAATAA-TTC TAA-----------------A----TTTCTGTG---------CATTTAAAAACATGGCCT CAAA--ATA-TATACTTTAAAAAGTGACAAAAAT--AA----TAGGAGA---------AC TGGATAAATCC------ACAACCATAGTGGGCAATTTTAACA----------------CA TCTTT------CTCAGT-AACTGATAGAACAA---------------------GCACAC- -----AAAA-------------AATTAGTAAGATTCAGCATGATCTGGAC--AAACTTGA CA-----------------ACCTAATTGACATGTATA--GA----ACCCGGCACTCAACA AC---TCCAGAATGCACAT------TCTTTTCAAGTG-----CA--CAT-GAAGCATTTA --C----CAAAATTGATTATATGCTGGGCAATAAATCAAG-------------------- -TCTCAATAAACTTCAAAGGA--CTGAAGT--------------AAAATATAGT------ -GTATGTTCTCT---GACCACAATGAAACTTAAGCTAGAAACCAAT-------------- ----------------------------------------------AATA--------AA --------------AAG-GTAACTAG---AAAATCCCTAA----ATGTTTGGAAA--T-T AAGCAATACA-CTTCTAAA---TA-ACTTCCGTGGGTCAAAGAAGA--AAT--TAGCAAT GGAAATA---------------AGAAATTAATTT---TACCT------------------ ------GAATGATAATGTAAAA------------TATGAC--GTATTGAAACGTG-TGA- -------TGCAGCTAAAATCATG-----------------------------CGTAGGGA GAAATGTGTATAGCATTA----AATGT----ATATATTTGGAAAG---AAGAAAGGCTG- --AAAATC----AAGCCAATCAATCCATCTT---AATAAG---TAGGAAAATAGA---AA AAATAACGCAAATTAAAC-------------CCAAGGA--ATGCAGAA-GGAAGAATATA CAA---AAGTTAAGA-------------------GCAGAAATT---AA-T-GAAATAGGA GCAAT--------------------------------------------AATGTAT---G AGAGAAAATC-A---------ACC----AAACAA-AAAATTA------TTTCCTTAAAAC AACGAA------------------------------------------------------ --------------------------AAATGATAA-----AATTAATAAACATC--TTGG CAA------GACCGA--TCAC-----------AAAGA------------------AGAAG GCAAGAGA-AGGCAC-----------------AAATAAGCAATATAGCAATA-----TA- ---------AGG-AATGAAA--AA----------GAGGA---CAAAGGAACAAATATT-A CA-GACATT--AAAAAGAT-AATAAA---------AGGATATA--ATGAA---------- -----------CTA---GTTTATGCCAATAAACAATTTGACAACTTGG---TTAAAAT-- TGACAAATTCATAATTGACACAGAAAAAA-----------------ACATTACCA----- -AAAGTGACACA----GAAGAAATAAAAAATCTGAAT----------------------- AGTCC------------TA-TAGCTATAAAAGAAATTAGATGC---------ATCCATAA AGAAAAACTTCCC-------ATAAAGAAAAC---TTCAGGCCC--AGATGG--------- ------------CTTCATCAGCAA--AG-------------------TTCCA-------- ------AATTATTTTAAAAGAAAAAAACTAA--CA-CCACTC----------TTACATAA ATTCTTCATACTTCGGGAGAATAGAA--------AGAA-GA-----------AAAACTTT CCAATTCATTTC-----ATGATA-------AAAAA---AAACTTG-ATAC---------- ----------------------------------------CAAAATAC-------CCTAC AAA---------------------TTC---TTTACAAAAAA---GAAAAATTAC------ -------------A-GGTCAATCT-TGCTC----TCATAAACATAAAT------------ ------------GCAAAAATCC-TAG--------------------G----TAAAATATT AA--AAATTC------------------TA--TC--------------CA--GCA----- --------AAATATT---------AAAAAATTAAATC---CAGTGAT---------ATAT AAA---AAGGA-TT----------CATTCCA------------GG--AATGCAATACAGG ATTGATTATATTAAATGCGATAACTC-AATTTTGCATTCAA--AAATCAATCAG--TGTA ---ATTCATGTCAT------TAACAA----AATACAGGAGAAAAAT---TGTACTA---- -TTATCTCCTTAATAGGCAT---AGAAAAATAATCTGATAAAATAATTCAACATCCGTTA AAATACTACTACTACTATAA---------TAATAATAA-----ACTTCTTAGA---AAAC TAAGATGGAAGAGAATAGAAGGATCTTTAATCAGACAAA--------------------- ------AGGTGTGTAC--ACAAA--------CTTATATA-----------AAACATCACA TACTTAATGGTGA-----AATAATTGAATGT----TTTC---CTT----CA--GGAACTA AAAATG----AGACAAGT-ATGC--CTACTA----------------------------- ------------------------------------------------------------ ----------------------------------TTACCATTTCTATTC---AACATTGT ACA---GAAGATTCTAGGCAGCTAAAA--------AAA-GC------AATAA---AAGAA --TTTTAAAAGAA---AAATAAGA---TAAAAGGTAAATGGATTGGAA--C--------- ------TATCATTA-TTAAA---ACTGAAATTATTGATAT------AAATATAAATGTAC AAAAAACA--CGA-------TTGTATAC---------A---------------AATAAAC TATTAGCATT---------AA--TAAATAAATTTAGCAATGATTTG-----CAGGATAT- --AA-AACACTGGCTAT----------------CAGGTCAA----TATCATTTCCACATA GTAAAAAT----AAAT-------------------------------------------- -----TATATCTT--TC-TATTCCAGG---------------ACCAAAGAAT-----TAG A------------------AAATTAATTTTA------AAAATTATGTCATTTACAATAAC ATCA--------------------AAAGATG---------AAA------TTCCTAGGAAT AAAATT--------CATAT-CAAATACGTA---A------ATCTCT---AC---GGAGAA CTAGTAATACT------AAATA-AAAGGATTCGAAAAACCACCACAATGAAA-------- ------------ACCT--CAAT--AAT---TGGA---GG--GATATGGAAGACTGACTA- --TGTTT------ATG-AAATAAATAACTC-ACATAAATTGTT--------------ATT TAAGGAT------------------------------------------TCAAT--TCTA TGC-AA--ATGCACCTATA-------------------AAAATTTCAATGTA---GTC-- ------C-CATTCAAAAT--C---------------------CCAGCA-GC---TGTTCT ------------------------------------------GGTAGAACTTG------- ----------------------ACAAGCTGAT------TCTAAAA---TTTATATGGAAT T-------GCAAAGGGCCAA---GA--ATAGCCAAGACAATCTTGAAGA---AGAA--GA AGA---AAGTAGTTTTGTTCGGA--GAACTTACT---TGACTGGATATCAAGCT-----T TATTTT-------------------------AA----GTTA-AGT-AATTAC---AA--A AAGATGCTACGTTGTATTAGCTCAAGGATAAATCCCCCTCCCC---AAAAAAAAAAA--- ---AAAAAAG--CAA--ATGG-AATAGAACAGAG--CTT------AG---AAACAGACTT ACCAC----------------ATA-------TATATGG----ACACTT--TATTTAT--- ATCAAAGAGGTGACATTGCAGCAA--A-------------------ATGAA--AA---AA GG------------TTGTGTTTTT--CAATAAATGG---------------TGCTG---- ------G-GCCAAT--TAG-ATATCCATTTAAGGTAGA----GATGGGAAAAAA---AAA ---------AATTGAAACCCTAATCTCCTTCCCACTGGATTATATA--TAA--ACAGAGA AAAA-TCAGTT-CCAGGTGG---AT---TGTAGAT---CTAAATGCGTAAAAAGTAAAAG CAT----------------------------ATTCTGGAA---------------AGAAA TTACATA------T------------------G-AGAGTATCCCCATAACCTTGAAGTCA ATGGGGAGAGAAAGAGC-----TCTTAAACAA-AACAAAACAAAACGTCTGAACCATAAA ATAAAGGAATCCAA----TAT---TGATAAA-TTGGAC----------TACATTAAC--- ATTAGGAT------------------CTT-CTGTAAAT----CA--------------TC -AAAAGATACCCT--------------AAAGAGTTGGAAAG------------------- ------A-------------CAGTCT-------CAGAG--T-GA------AAATTATTT- --GCAGAAGATACATATTCGGAACT-------AGCAAAGAAC--------TC--ATATT- ---TATAATATATACCAGCAAATTAGAAAGATATCCTCATA--TCAAT------------ ---AAG------AAATTTTTAA--AAAAA---GAC--AAACGAA-TAAGAATAAAGTGGA A--ACA---------AGA--CCTGA---AA---TGGAACTT------------------- -----CACAAAAGAG--------GATATTC---A--ATGACCTCTA-AAACATATGAAGA GCT----------GTTTAAGCCAATTTAGTAGTCA------------------------- -----AGGATGATTTAAA-----------------TTAAAAACCACA-------AT---- ----GA---GATACCA---------CTAT----ACACCT-------TGGCATTCAA---C A--AAAAC-------TTTGACA-----ATATCA-AGTG--T------------------- ------TGGT-GAGAACATG----------AAGAATACAAATTATACAAGGTGTAGTCAA GGGTGTGAAATCACTGGAACACTCAT-ACACCCCTGG--TGGG----------------- ----------AAAAT--A-------------AATT---GATAC----CATTACTTTGG-- --------AAAAGTT--TGGAA--A-TAACTA--TTAAAATTAAAT--ATACATATAATG CCCTT---GA-ATCTAGAAATTCCA----------------------TTCTAAG-TATA- --------------TA-CCTAACAGAA-------------ATGCATAA----A------- --------------TACGTACACCATAAA-ACATGT---------GAGAG----AATATT CATT--GCAGCATTGTTTGTAA-TAGCCTCAAACT--G--GA--AACA--ACCCAA---A TGTCCATCA---ACAGTAG-----AATAGATAAAT--AAAT----TA------------- -----TGGTA-------------------------------------------------- ------------------------TATTTTC--ATGCAATGGAATAC-----T--ATACT ACAGTGA----AA----------------------ATGAATAAACTGCAGCTACAT---- ------------------------------------------------------------ --------GCAACAACATGGATAAAATC---TCACAAACATACAGTTGAGCAA------- ------------------------------------------------AAGAAGCCAGAT ACTA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------ATAAATAGATACCTTTACA CAAAAT---TAGTCCATTTAT------------ATAAAATTC------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAACAGGCAAAACTAAATTATGGTGTTTAAGGAATGCACACTTA-- ------------------------------------------------------------ ---------------------------------------------------GGTGATAAA ACTAAAAAAATAATTGTTTTAG-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAA--------TTAGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTGTTT-----------------------------------------------A CCT---------------------------------------TTAAGGAGAAGGAAGG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TGCTGTAGGACA--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------ATGCATGAGGGCTCTGGGT--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------TGCTGGTAATG------------------------------ ---------------TTCTATTTCTTGATCTGGGTGGTGGTTACACG------------- ------------------------------------------------------------ ------------------------------------------------------------ ---GGTATTTACTTTTT------------------------------------------- --------------------------------------------AACTAC---------- ------------TCATTAAACTGGACATTTA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TATTTTATGCAGTTTTTTAATTGTGTACTTTTTTGC--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AATTAAAAGTTTTAAAA---------------------------------- ------ >L1ME3A ------------------------------------------------------------ ------------------------------------------------------------ --------GAATTCTTCTTCCAACT----------------ATGATGGAGCA-------- ----TCTTGTAAAATTAATTAGCTTGTCTCGGACCAACCCTCCCACCGAG---------- ---------------------------------------AACAACTATAAAAGCTG---- -GTTAAAATTC------AAAACTTATCTGTTTGAAGGCATCAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------AGATTTT----CTATGTCATCAGG------ACTTAAGGAG-------------- ------------------------CCAAGATTCC---------A-GAGAGAAAGGAAACT CACAGA------------------------------------------------------ GGT-------------------------------------GAGCCCAATCTTCTGCACTG CTTTTCCCCTTAAAAGATTTACTTATTGGTGCAG-----GT---CATGGGGCTGAGAGAC CA--------------------------------------------------AGCAGAAA ACAGTAGCCCAGAGGTTTGGACAAACTCACAGAGCTGTAGAAAAAAAAATTGGAGTGCAG GGCTAC-------------------------------------------CAAGTTAGCAA GAACTTGAGGGGCCAATATCAGAGAGAAAAGG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------AAATCA----CAGGGCAA--TG GAATTAGAGAGTTCA-----------ACATTCTGCACCGCTTTTCCCCTCGAGGCATTTA TCAAATTATGAAGCGG-------------------------------------------- -------------------------------------------CACAGGGTAGGAGGCTA AGAAGCCAAGCAGAAAGCCTTTGCTAAGAGGC-------------TAAAAAGGTAAATAG AAGTT------------------------------------------------------- -------TTGGCAGT------------CTCACAGTG---CTGGAGAGACAAAAATTAGAG TT-------------------TAGG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------ACCTGCCATGGGGAAGGGTTCCTGGAAAT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TTCCCAGGAT-------CTCAGTTGGGACACCTGGAGGGA TGTGCCCTAGGAGTAAGGGCAAACCAGA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AATAGACTAGGCCCCA ATAA------GACCTGAAACCAACCTCGAATCAGCTCAGTC------------------- ------------------------------------------------------------ -----------------------------------------------------------C TTGAT-----------------TGGATCAAGGTGATCTAATTATACATGTCCCTAGCTGC CTGGCAGAAGCAAA--------------------------------GGTAAATCCTCTCT G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAGGAAGAT-----------AACATCATCTAGATCCT CAAATTATCCTTTCCAGTTTTTCATACATAATGTCCAGCATTCAATCAAAAATTACCAGG CATACCAGGAAACAGGACCAAATGACTAAAAACCAGGAGAAAAGAAA------------- --C-----------AGACAATAGAAACAGACCCACAGATGAT------------------ ----------------------------------------------ACAGATATTAGA-- ---------------------------------------ATTATCAGACAT--------- ---------TGATTT--------------------------------------------- -TAAAATAA-------------------CTATGATTAATATGTT---------------- ------------------------------------------------------------ -------------------------------TAAGAAAAGA-----ATTAATT------- ----------------------------------------AAAGAGAAG--------AAA ACTG-------------------------------------CCAA---A--A-------- -------ATT----ACACTAGTTC-------------------AC-CAC---CAATGGAT CCAAACC----------------CAG---AAGAAATCCCTGATCTACCAGAAAA------ ------AGAA------------TTCAGGAGGTTAGT-TATTAAGATAATAAGGGAGGG-- --ACCAGAGACAGGC--------------------------AAAGCCCAATGC-----AA AGAAATC----------------------------------------------------- --CAAAAAA--------------------------------------------------- -TGATACA----------AGAAGTGAGGGGAGAAATATTC-------------------- -------------------------------------ATGGAAATAGATATCTTAAAGAA ----------AAAA---------------TGATCAA------AAA---------TCCTA- GAGT----TGAAG---------AATTC---AGTGAAGGAAATAAAAAATACAAGTGAG-- ---ACCTTCCACAACAGA----------------ATAG--------------------AT C--GAGT------------TAGAAGAGAAGACAT-AAT-TTCTA--AACTTGAAGAC--- -AAGTCTTTGAAAA-A-----AACACAAGCAA--------------ACCAAA---GAAAG AAAA-----GAGCAAA-AA---------TAATACGGAATGCATAC--AGGATAATAGGAA ATACA--------A---TAAAGCG--TACAGAAATTCAC--A-CTGTGGG--TTAT---- ----------CCAGAAG--AAGAGGGA----------AAAGGTATAG---------AAAT CATATTT---AA-----TAAAATAACT-----GAAAACTTTCCAAGTTG----------- ---------TAGGACAGATAT--GAAC--ATCCAGATCC---ATAGGAAGCTCAAAGACT CCCCAAATA------------AATTTGA-CCC--------------AAAGAGGTCCTCTC C-------A---------------------AATGACATTATAGTCAGATA------AGT- AAAAGACAAAC-----------AAAGAATTT----------------------------- -------------TTAAAAC--AGAAAAAGA---AAAGCGTCAAGA-------------- -----------GAC---ATATAAAGA-AATCCCAA--------------TTAGACT--AA CAGTAGATTTC-----TCAGCAGAA--ACCTTA-CAAGC------CAG-GAGAAAACG-- -----------TAA-TGATAGA-T-------TCAAAG--TACTGAAAGAAATAAAACAAG GAGAAAATAGTATAAAAAAAAAC-TG--CCA--GACAAAAA--------TAT---TATAC CAA-----------CCCAACTTATCT-----TTCAG-AAATGA-------AA-------- ------------------------G-AAAAATAAAGTTTTTTACAGAGAAGC-AAAAACT GAGGGA-ATTCATCATCACTAAAC---TTACCTTAA-AAAAA------------------ --------------------ATGCTTAAAAG----------------------------- -----------------------------------AGTGC--------------TTAGGA AAA---------------------------------------------TGATCCCAGATG GAAGCTCGGAAATGCAGGAAGGAATGA--------------------------------- -------------------------------AGAGCAACAGAAAG--------------- ------------------------------------AGTAAAT----------------A TGCGGTAAATCTAAATGAATATTGACTGTATAAAATAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------TAATTATAATGTCTTGTGGTGTTTAAAATATATATAGAAT-- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------TAAAATGTATGACAACAATAACTTAAAAGGGAGAGGA GAGGTAAATGGAGTTAAAATG--------------------------------------- -----------------------------------------------------------T TCTAAGGTCCTTGC---ATTGTATGGGAAGTGATAAAAGTACTAATTTAT---------- --------ATTA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CTTTAATAAG--------------------------TCAA GGATGCATGTTTT--------------------------AATTTCTAGG-GTAATCACTA AAAGAATAAT-AAAAGAATGTATA------------------------------------ ---------------------ACTAACAAGCT---------------------------- ------------------------------------------------------------ --------------------------------------------------AATAGAGGGA AAATAGTAAAATAATT-AAAACTAAGATCATTGAACTAATAACCAAAAAGAGAAAAAAAA ACATAGAACAAATG---------------------------------------------- ---------------------GGACAAATGAATA-------------------ACAAATA GTAAG------------------------------------------------------- ------------------------------------------------------------ -------------CGAGTTCAAATTCACAA------------------------------ ------------------GGACA------------------------------------- ------------------------------------------------------------ ------------------------ACCTA--TCAATAATAAC-TTTGAAT-------A-T AAAT--AGATT--AAATTC---TACAATT----------------AAAAAAT------AT AAAC--TGGCAA----AATG--------------------GAA---AAAAAATACCCATG ACACCG-------TAT-GCTTTATA-AGGGAGATCCACCT-AAATT--TTAAAGACACAT A-TAGACTAAAAGTATAAAAA----------------AAAGA----A-GACTATACCATG CAAATGATACAAAGCAAATGG------AAAGC---------------------AAAA--A AAGCAG--CGGT----AGTTATACTTATATC-TGAAAAAACAGACTTTAAG-GC------ ----AGAAAATG---TTATAAGAGAC-AAAA-AAGGGAATAATTTAAATAT------AAT GATTAA---AAACTTAATTGGTATCCATAAA---GAAA--------AT-ATAACAA-TTC TAA-----------------A----TATTTATGGGACTTACACACCAAACACATTAATAC AGAA--ATA-TATAAAAAAAATAATAAAAAAAAT--AA----AAAGAGA---------AA TAGATAAATAC------ATAAAAATGGTTGGAAATTTTAATA----------------CT CCATT------AACCAT-AATTAACAGACAAA---------------------CAAAAA- -----AAAA-------------AATTAATAAGGAACTATTGGATATAAAA-CTAAAAAAG GA------AAAAATTG---ACATAACTGACATATATA--GA----ACATTTTATCTAACA AC---AACAAAATTTAAAA------TACTTAAAAATG-----CA--AAT---AATATATT AAA----GTACATAGAAAATATTTTAGGTCATAAATCAAT-------------------- -ACTGAATAAATGTAAAAAAA--CAAAATT----------------AATAAAAA------ -ATATGTTCTGT---GACCACAGTGGAA-TAAAACTAGAAATAAAT-------------- ----------------------------------------------ATGA--------AA --------------AAG-ATAATTAA---AAAATCCACAA----AAATTTGGAAA--A-T AAACAAAATT-ATTATTAA---AA-ACAAATT--AGGTAAAAAAAA--AAT--T-AAAAT GGAAATT---------------ATAAAATATTTT---GAATT------------------ ------GAATGAGAATAA-AAA------------TATAAC--ATATA------------- AA-----TAC-------------------------------------------------- -----------------------------------ATTAAAAAAG---ATAAAAAACTA- --AAAATAAAT-AACTTAA-TAATAAACTTT---AAAGAGT--TAAAAAATC------AA AA-----TAAAAAAAAAA-------------AAAAAAT--AATAAGAA-AAAAAAAAATA ACT---AAAATAAAA-------------------ATTAAAATA---AA-T-GAAATAAAA AATAA------AA------------------------------------AAA-CAA---T AAAAAAATTA-A---------AAA----AAACTA-AAAGTAG------ATTTTTTAAAAA AATAAA------------------------------------------------------ --------------------------------TAA-----AATTGATAAAAC----TTAG AAA-ATAAAAATTAG--TAA------------TGAAA------------------CAAGA A--------ATATTG-----------------AAAAAAA--------TACCA------T- ---------AGA-AATAAAA--GA----------CAAGA-----------CAAATATT-A CA-GACATG--CAAAGGTT-CATAAT---------GGAAAACT--ATGAA---------- -----------CAA---TTATTTGCCAATAA---ATTAGATAACTTAG---ATAAAAT-- GCATAAATTACT----------AGAAAAA---------TAT-----TATACAAAA----- -ACATTAATTCATACAAAAAAAATAGAAAAAATTAAT----------------------- AAAAATATAAAAAATCATA-TAAATAAAAAAAAAATTAAAA-T---------AATAAT-- -TAAAAACCTAAT------ACAAAAAAAAAT---TATAGAAAC--AAATAG--------- ------------TTTTATC-AGCA--AA-------------------TTTAC-------- ----ACAAAATTTT---AAAGAA-AAACTAA--TA-CCAATC----------TTACATAA AATCTT----CC---AAAAAATAGAA------AAAGAA-AA-----------AATATTTT CTAATATATTTT-----ATGAAGCT-----AATAT---AACCTTA-ATAA---------- ----------------------------------------CAAAAAAT------TCTAAC AAG---------------------GAA---ATTATAAAAAA---GGAAAATTAT------ -------------A-GACCAATAT---CTC----TAATAAATATAGAT------------ ------------GCAAAAATCT-TAA--------------------A----TAAAATAAT AGA-AAATAG------------------AA--TG--------------AA--AGA----- --------AAATATA---------AAAAAGATAATCCA--TCATAAC------------C AAG---TAGAA-TT----------TATTCCA------------GG--AATGCAAGATTGG -T----------------------TT-AAC-----ATATAT--AAAGCAAATAA--TATA ---ATACATCACAT------TAACAG----AATAAAAGAAAAAAAT---ATAACAA---- -TTATCTCAATA---GATGC---AGAAAAAGCATTTGACAA---AATTCAACATTCCTT- ---------------TATAT---------TTGAA--AA-----AAATCTTAAA---AAAC TAAGAATAAAAGGAAATT-----TTCTTAATATAATAAA--------------------- ------GAGTATCTTTAAAAAAAACTTATCTACTACAGCTAA--------TAAAAT--AA TAATTAATGGTGA-----AAC-ATTGAAAGC----ATTC---CTT----CT--GAGAACT GAAATA----AGACTACT-AGCC--ACTATC----------------------------- ------------------------------------------------------------ ----------------------------------TCTCCAATTATATTC---AATTTTCT TTT---TGTTGTAGCAGCCAAAATAAT--------CAG-TA------AAGAA---AAAAA --AATAAAGTATATACGGATTGTA---AAGGAA------GAAGTAAAA--C--------- ------TTTCATTA-TT--T---ACAGA------TGACAT------AATTATGTATACA- -GAAATAT--CAAAAAA---ATTAACTA---------A---------------TA--AGT TATTAGAACT---------AA--TAAGTAAATTTAGCAAGG--TTG-----CTAGATAT- --AA-------------------------------GGTCAA-------------TAT--- ATAAAAAT----CAAT-------------------------------------------- -----TGTATTTC--TA-TAAACCAGT---------------AGAAAAAAAA-----CAA T------------------AAAACTAATA-AAA----AAAACTATATCATTTACAATAAC AATAAACAAAATAAAAAGAAAAAGAAAAAGAAAAGAAAAGAAAAAAAAATACAAAGGAAT AGAATT--------AA--C-AAAGGATGTA---C---AAGATCTCT---ACAA-GGAAAA CTACAAAACAT------TG----AAAGTAAATA--------------------------- ------------ACAC--ATACAAAAA---TAAA---GA--CATAC---------CCAG- --TGATT------ATAGAATAGGAAGATTC-A---A---TATT--------------C-- TAAAAATA-----------------------------------------TTAAT--TCTT CCT-AA--ATTAATCTATA-------------------GA---TTCAAAATAATTATT-- ------C-CATTTGAGAT--A---------------------TTATTA-AA---TGATAT ------------------------------------------CACACAATTTG------- ----------------------ATAAAAATAT------TTTAAAT---TTCACATGGAAT C-------AAAAAAGTAACA-------ATATACAAAACAATATTGTAAA---TAAA--GA AGA---AAAAGAT-------GGA--AGAATCACT---TTACTAGAAATCAAGTT-----A TATTAC-------------------------AA---TGCCACAAT-AATTAA---AAC-A ATG--------------AGTTACTGG--TA------------T---AAAAATAGAAA--- ---AATAGAC--CA---ATGG-AACAGAATAGAG--TCC------AA---AAAGAGAA-- -CTATACGTATACTCTATATGACATATAATATTTATAA----CCATCT--GATCTTG--- GACAAA--ACGGACAAAAACATAA--A-------------------TTGGG--GA---TA GA------------ATACCTTGGT--AAAAAAATGG---------------TTCTT---- ------A-AAAAA---TGGTCCTGCCA---------------CAATT-AGATAA---ACA ---------TATCTAAAAACT---AATCT-----------TTGACC--TTA--T---ACC AAAA-TACACA-CAACATTT---AA---TTTAGAT---TTAAAATTA--AGACCTAAAAC TAT------------------------AAAAATCATAGAAATAAAAGTTACTGGAGATAA ---CCTA------G------------------G-AAAAACCCTTCAGGGTATTG--GTA- -----TAGGCAAGGATT-----TCATTAATAA-GAAACAA---AAAGCAATAACAATAAA CCACAAAAA---AAA---AAT---AGATAAA-TAGATC----------CTAATG-AA--- AATAAAAA-----A------------CTT-CTGCA-------CA--------------GC -AAAAGGAACTGT-------------CAGCAGAACATA---------------------- --------------------CAAGTT------ACAAA-----GAGAATAAAAGAATTTT- --ATATATT-TATAT--------CT----------AAGGCAC---------AGAATACAT ACATAAAAGATTCAAA-----ACCAGA------------AA--TCAAT------------ ---AATT-------------AATAAGAAACACAAT--AGTTTA--TATA---AAAATAGG T--TAA---------AGA--TCTGA---AA---AGGCAATT------------------- -----CACAAAAGAA--------AATATAC---AA-ATGGTCAAG--AAAACTATAAAAA CGT----------GTTCAATTTTATTA-ATGTTCA------------------------- -----GGGA-ATTTCAAA-----------------TA-AAAACCACA-------AT---- ----TA---AATATCA---------TATT----TTGCCATCAAGAATGGCAATAAT---G A--AAAAA-------ACAGAAA-----ACAGTA-AGTG--T------------------- ------TGAT-AAGGACGGT----------GTGAA------------------------- ------------ATGAGAATTCTAAT-ACACTGTTGG--TGGG----------------- ----------AATGT--A-------------AATT---GGTAC----AACCACTTTGG-- ------AAAACAGTG--TGGAT--G-TTCCTC--ATAGAGCTGAAG--GTATAACTAAC- -CTTT---GA--TCCATCAATCAGA---------------------CTACTAGA-TATAC ATATACTAGAAATCTA-TGTAAAAGTA----CAG-----AAAAAATCA----T------- ----------------TAGAAAGAATAGACATTTGC---------GCATG----CAGGTT TATA--GCAGCAAGATTCATAA-TTGCTAA--------------ATTAATAGTTAA---A AATCCATTT---------------GTTGGATGGAACCAACA----CA------------- ------------------------------------------------------------ ------------------------------------------AATGC-----C--CATCA ATCTTAG----AA----------------------AAAATT------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------CAAAA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----GCAA---------------------------------------------------- ----------AATTAATCTAT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------GTGATAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAG--------TCAGGAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTAGTT-----------------------------------------------A CCC-------TTGGTGAGGG-------GAGGGTAGTGACTATGAAGGGGGCAGGGGGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GTCTTGGGTT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------CCGGTAATGG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------TTTTATTTCTTGATCTAAGTGGTGGTTACATG------------- ------------------------------------------------------------ ------------------------------------------------------------ -----GGT-GTATTCAC------------------------------------------- -------------------------TT-----------------TGTGAA---------- ---------AATTCATCAAGCTGTACACTTATGATTTGT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GCACTTTTC----------TGTGTATGTTTTATTTC--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TATAAAAAAT----------------------------------------- ------ >L1MD1 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------TAGAAGAAGT ATTTTTTAT-------------------------TATTCTTTTTAATAAA---------- ---------------------------------------AACAAAAAAAATCAATA---- -TAAAATATAA------AAA---AAACAAAAAAAAAATTATAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------AAGGAGA----AAAAAAAACGGAA------AACAATCAAGG-------AAATTA GAAAT----------------------------------------CAAAAAATAACATGG TGATGAGTACCCTG----------GGT--------------------------------- ----------------------------------------------------------TT TCTTTTTGCCTCATATATCCCAGACTTGGAGC---------------------------- ----------------------------------------------------TGAAGAAG CTGGCAACTCAGAAATACCAACAGGTACATTTTAAGAAAGCCCAACCAAAGTCCGCTCTC TTTAAC---------------------------------------CCAAAGAAAAAGAAG CAGTCTAGCAAGACAGAAAACTATCTGCTAAGAAACGCTCTAC----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TCTGTCTTAGCT----AAAGTACA--TA AAATAAAATTATGACCTCAATATTACTCATT----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------CCAGCAAAGGCTGAGTGGGGAGCCTA-------------GACTTTTACCCTCGC AAGGCTGTAATGAGGCGCT----------------------------------------- --CAAAAACCCCAAT------------TAGGTGGCC---TGATAGGGTGTCGTGTAGAGA AC-------------------TAGAGCGGTGATCCCCACCA------------------- ------------------------------------------------------------ ----ATCATAAATGATGTCCACTAATAACTT----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CTCTTCCCAT-------GTTGAGAGTAAAAACTATAATCC AATGGTAAACAAGTCACCTACACAATAG-------------------------------- ------------------------------------------------------------ ---------------------------------------TATCAA----TTGCTGCAACC TACCA-GTTTGGGAGCCAAAACCCC----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A CCCTG-----------------TGGGTAGAAATGACGCTCTCCCCCCACTGCTGTGTTGA TGGGGGTTAAGCGG--------------------------------GGAACAG------- ---------------------------------------------------------GGA CTTCTTGT---------------GCTACCTGGCCTTC----------------------- ------------------------------------------------------------ -------------------ATACATCAATAGACAT----CATGATGACATCTCCCCCCTC CCCCTGCTGGGGTGGTGT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------CAGAGAAAG-----------CCAGCTAAAACAGAGGG TTTAAATAAGATCCAGAGT-------------------CTCATAACGTAATAAAAACACG TAGGTTTTTAATTTAAAAAATCATTCATCCTACCAAGAACCAGGAAG------------- --A-----------TCTCAAGGAAAATGGATTGAAAAGACCATCAGTTGCCGA------- ----------------------------------------------CAACATGAAAACGG CAGTGATGTAGTATAATTTAAAGAGGTTTTAAAAGCA--GCCATCATAAAA--------- ---------ATACGTCAATGAGCAATTATGAACACACTTGAA------------------ -GCAAATGG-------------------AAAAATAGAAAGCTCC---------------- ------------------------------------------------------------ -------------------------------AGCAAAGAAA-----TAGAAAATCTCAGC AAAGAAATAGA---------------------------AGATATAAAGA--------AGA ACCAAATTGGAATCTT-------------TGGA--AATG--AGAA---ATAA-------- -------AAT----AAACTAAATTGAAAAGCTCAGTGGATGGGCT-CAA---CAGCAGAA TGGAGGG----GA------AACAAGG---AAAGAATCAGTGAACTGGAAGATAG------ ------AATAATGGAAATTGCACCTAATCTTAACAATAGAAAGAAATTAGACTAAAAA-- --AAAAAAAAAGAAC--------------------------AGCACCGAGCCC-----AA AGAATCT-----------------------------TACATTTATGTATTTAGAATACAT G-CTTGAAA---------------------------------------------TAGCTG AAATTACA----------GAAATGCTAAAATTATCTG----------------------- -------------------------------------------GCAAAGATTTTAAAGCA ----------GCCC---------------TGACAAG------AA----------TTTTA- GAAC----TGAAAAAACAGAATAATAC---AAATAACAAAATAAAAAGCTCAGCGCAT-- ---GATCTAGACAGTAGAAGGAAAAGGACAATGCAGGG--------------------AA CTGAAGAACTAAAACAAAAAACAATAAAAATACACAAT-TTCAGTAAACTAGAAAAT--- -AGAATGAAGAAAA-------TATACAATAGT----------CAGAGAAAGA---AAAAA AAGA---ATAAAGAAA-A----------------AGACAACTTTG--GAGTCATCTGTG- ACAAT--------A---TAAAAAAATATCTAATATTTCT--T-ACAATGG--AGTA---- ----------CCAAAAA-GAAAGAAGAAAAAGAG---GGGGGGTTA----------AAAA AGTACTC---AA-----AGAAATAATGGCT--GAAAACTTCCCAAATTT----------- ---------GGCAAAAGACAT--AAAC--CTACAGATTC-----AAGAAGCTGAGTGA-A CCCCAAATA------------GGATAAA-CCC--------------AAAGAAATCCACAC C-------A---------------------AGACACATCATAATCAAACT------TCT- GAAAACTAAAG-----------ACAAAAATT----------------------------- -------------TAAAA-----ACAAGAAA---AAAAGAAAACAC-------------- -----------CAC---TTACAGAGG-AAAAACAA--------------TTAAAAT--GA CAATAGATTTC-----TCATCAGAA--ACCATG-GAGGC------CAG-AAGGAAGTG-- -----------CCA---AAATA-T-------TTTTCATGTTCT-------------TAAA GAAAA-------------AAAAC-TG--CAA--CCCAAGAA--------TCT---TAAAC CAA------------GAAAATTATCT-----TTCAG-GAATAA-------GG-------- ------------------------G-AGAAATCAAGACATTCTCAGATGAAG-AAAAACT AAGAGA-ATTTGTCACCAGCAGAC---CTACCCTAA-AAAAA------------------ --------------------AGGATGAATAA----------------------------- -----------------------------------AGTTA--------TTTGTATAAACA GAA-----------------------------------------AGGAAATGATTAAAGA AGGAACCTTGGGACATCGGAAAGA------------------------------------ -------------------------------AAGACAACTGAA----------------- ------------------------------------AAAAAAT----------------- --------TATAAAAGAAGAAACCTTGGAACATCAGGA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AAGAAGAAAGAACATGGTAAGCAAAAATATAGG TAAATACAAT-------------------------------------------AGGCTTT CCTTCTTCTCTTGAGTTTTCTAAATTATGTTTGACAGTTGAAGCAAAATTTTTATACCAT CTTGTGTTGTGCTTCTAAACGTATGTAGAGAAAAATAATTCAATCAAATATAGGGAAGGG AAAGGGGCTTAAGGGAA------------------------------------------- ------------------------------------------------------------ ------GGTAAGGT---TTCTATACTTCACTTGAACTGGTAAAATGATAACACC------ --------AGTA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CTGTGATAAGTTATGTATA----------------TATAA TATAATACCTAGA-------------------------------------GTAACCAC-- ------------------------------------------------------------ --------------------------TATAAA---------------------------- ------------------------------------------------------------ --------------------------------------------------AAACCGATAC ATAAATTAAAAATGCT-ATAGATAAATCAAAATGGAGGTCTTACAAATGTTCAAGTAAAA CGCAGAAAGGAAAAAAAAAAAACA------------------------------------ ---------------------GAAACAAAACACA--------------GA---ACAAACA GAAAA------------------------------------------------------- ------------------------------------------------------------ -------------CAA-------------------------------------------- ------------------------------AAAATAAAT--------------------- ------------------------------------------------------------ ------------------------AAATA------TAATTAC-ATTAAAT-------A-T AAAT--GGTCT--AAATATAAAAACAATA----------------AAAAGAA------AA AGAA--AAATAG----AGAG---------TAT-------AAAA---AAAAACCAAAAAA- -------------TAT-ATTTTCTA-AAAAAAACTCACTT-CAAAT--ATAATAATATAG G-CAGGTTGAAAGTAAAAGAA---T------------GGAAA----A-AGATATATCATG C--------------AAACAT------TAATC---------------------AAAAG-A AAGCAG--GAGT----GGCTATATTAATATC-AGATAAAGTAGACTTCAGA-GC------ ----AAAGAAAA---TTACCAGAGAC-AGAG-AGGGACAT------TATAT------AAT GAAAAA---AAGGTCAATT------CACCAA---GAAA--------AC-ATAGCAA-TCC TAA-----------------A----TGTGTATG---------CACCAAACAACAGAGCTG CAAA--ATA-TGTGAAGCAAAAACTGATAGAACT--GA----AAGGAGA---------AA TAGACAAATCC------ACAATTATAGTTGGAGACTTCAATA----------------CC CCTCT------CTCAAT-AATTGATAGAACAA---------------------CTAG--- ------AAA-------------AATCAGCAAGGATATAGAAGAACTCAAC-AACACCATC AA------CCAACAGG---ATCTAATAAACATTTATA--GA----ACACTCCACCCAACA AC---AGCAGAATACACAT------TCTTTTCAAGTG-----CC--CAT-GGAACATATA --C----CAAGATAGACCATATCCTGGGCCATAAAACAAA-------------------- -CCTCAACAAATTTAAAAAAA--TTGAAAT----------------CATACAGA------ -GTGTGTTCTCT---AACCACAATGGAA-TCAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------GA --------------AAG-ATAACAGG---AAAATCTCCAA----ACACTTGGAAA--C-T AAACAACACA-CTTCTAAA---TA-ATCCATG--GGTCAAAAAAAA--AAT--TCTAAAG ATAAAT----------------AAAAAATAAATT---AAACT------------------ ------AAATAAAAATA--AAA------------TACAAA--ATATTAAAATTTTGTGG- GA-----AACAGTTAAAGCAGTG-----------------------------CTGAGAGG GAAA--TTTATAGCACTA----AATGC----ATATATTAGAAAAG---AAAAAAAGTCT- --CAAATCAAT-AATCTAA-GCTCCCACCTC---AAGAACC--TAGAAAAAG------AA AA-----GCAAAATAAAC-------------CCAAAGC--AAGCAGAA-GAAAGGAAATA ATA---AAAATAAGA-------------------AAAAAAAAA---AA-A-AAAATAAAA ATAAA------AA------------------------------------AAA-AAA---A AAAAAAAATA-A---------ATA----AAATAA-AAAACTG------GTTCTTTGAAAA GATCAA------------------------------------------------------ --------------------------------TAA-----AATTGACAAACCT---CTAG CAA------GACTGA--CAA------------AGAAA------------------AAAAA A---GAAA-AAACAC-----------------AAATTAC--------CAATA-----TC- ---------AGG-AATAAAA--CA----------GAGGA---TATCACTACAGACCCT-G CA-GACATC--AAAAGAAT-AATAAA---------GGAATACT--ATGAA---------- -----------CAA---TTCTACACACATAA---ATTTGACAACTTAG---ATGAAAT-- GAACCACTTCCT----------TAAAAAA---------CAC-----AAACTACCA----- -CAATTCACCCA---ATATGAAATAGATAATTTGAAT----------------------- AGCCC------------TA-TAACTATTAAGGAAATTGAAT-T---------TAAAATTT -TAAAACCCAATA------AAAAAAAAAAAC---CACAAGGTC--AAATGG--------- ------------ATTTAAT-AAAAA-AA-------------------TTTTA-------- ----CCAAAAATTA---AAAGAA-AAATTAA--AA-CCAATT----------CTACATAA TTTTTT----CC---AGAAAATAGAA------AAGAAA-AA-----------AAAATTTC CAAATTCATTTT-----ATGAAGCT-----AGTAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAAAC AAA---------------------------ACAAGAAAAAAAAAAAAAAAAAAA------ -------------A-AAACAATAT---CCC----TTATGAATATAGAT------------ ------------ACAAAAATCC-TTA--------------------A----CAAAATATT AGC-AAATAG------------------AA--TT--------------CA--GCA----- --------ATATATA---------AAAAAAAATATATA------AAC------------C AAGCCAAAGGGGTT----------TATTCCT----------------AAAATAA------ ---------------------------AAA-----ATTTAA--AAATTAATCAAATTATA ---ATAAATAATAT---------TAG----GATAAAGAAAAAAAAT---CACATAT---- -TTATA---------AAAAC---AGATAAAGAATTTAAAAA---AATTCAAAACCCATT- ---------------CATTA---------T---A--AA-----AACTCTCAGA---AAA- -----ATAAGAAAAAAAT-----TTCTTAAACTTAAAAA--------------------- ------AAACATATAA-AAAAAA--------CCTATAGC-----------TAACAT--TA TACTTAATGATGA-----AAG-ACTGAATGC----TTTC---CCC----CT--AAAACTA GGAAAA----AAGCAAAG-ATGT--CTACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCTCTTCTTTTT------AACATAGT TAT---AGATGTTATTGCTAGCCAATT--------AAA-TA------AAGAA---AAAAA --AGTAAAAAAAATACATATAAAA---AAGAAA------GAAATAAAA--A--------- ------TGTCCCTA-TT--T---GCAGA------TGACAT------GATTGTCTATATA- -GAAAATC--CCAAGAAAACAAAAAAAA---------AAAAAAAATCTAAAAAAA--ATA ATCTAAAACT---------AA--TAATTGAGTTCAGCAAGG--TTA-----CAGGATAC- --AA-------------------------------GATAAA-------------CAT--- ACAAAAAT----CA---------------------------------------------- ---------TTTCTATA-TATAATAAC---------------AATAAACATA-----TGG ATTAAAAAATTTAAAATACAAAAAACATTAAAA----AATATAATACTATTTATAATTAT T---------------------AAAAAAATA---------AAA------TTTTTAGGTAT AAATAT--------AA--A-AAAATTTATA-------AAGAACTTT---ATTGCTAAAAC TTATAAAATAA------TAATG-AAAAAAA----AA------------TAAG-------- ------------ATCT--AAAT--AAA---TGGA---GA--GATAT---------AATG- --TGTTC------ATG-AATTAGAAAAATT-A---A---AAAA--------------G-- TAAAGATG-----------------------------------------TCAAT--TCTC CCC-AA--ATTGATATACA-------------------GG---TTTAACACA---ATT-- ------C-CTATCAAAAT--C---------------------CCAGCA-AG---ATTTTT ------------------------------------------TGTAGATATAG------- ----------------------ACAAGATTAT------TCTAAAA---TTTATATGGAAA A-------GCAAAGGAACTA---GA--ATAGCTAAAACAAATTTGAAAA---AGAA--AA ATA---AAGT--G-------GAA--GGAATCAAT---CTACCCAATTTTAAAAC-----T TAATTA-------------------------GA---AACTAAAATAAATCAA---AATGG TTG--------------GAATAGTGGGAGA------------G---AAATAGAGACA--- ---AATAAAT--TA---AACA-AACAAAATAGAGAACCC------AG---AAATAGAC-- -CAAA----------------AAA------------AATTGCCCAAAT--AATTTTT--- GACAAA--GGTACAAAAGCAATTC--A-------------------ATGGA--GA---AA AG------------ATAGCCTTTT--TAACAAATGG---------------TTCTT---- ------GAAACAAT--TGG-ACATCCA---------------TAGGC-AAAAAA---TT- ---------AACCTCAACCTA---AGTCT-----------CACACC--TTA--T---ATA AAAA-TTAATT-CAAAATAT---AA---CATAGAT---TTAAATGTA--AAATGTAAAAC TTT------------------------AAAACTTTTAGAA---------------AAAAA ---AATA------A------------------G-AAAAAATTTTAGGAAAACTA--GGA- -----TAGGCAAAGTGT-----TTCTAATTAA-CACCACA---AAAACAAAACTCAA--- --AATAGAA---AA----AAT---TAATAAA-TTAGAC----------TTCATCAAA--- AATTTAAA-----A------------TTT--TTTT-------TT--------------GT -AAAAGACCCTGT-------------TAAGAGGATGAAAAG------------------- ------A-------------CAAGCT------ATAGAA--T-GGGAG---AAAATATTT- --GCAAACCACATAT--------CC-------AACAAAAGAC--------TA--ATATC- ---TAAAATATATAAA-GA--ACTCTC---AAA------AC--TAAAC------------ ---AAT------AA------AA--AAAAAATAAATACAATTAAA-GAAG---AAAATAGG AAGAAA---------AAA--CAAAA--------AAGAATTT------------------- -------TAACAGAA------TTGATTGAA---AAGATGGCAAAT--AAACACATGAAAA GATTTTA------GAAAACCTTTATT--AGCAATA------------------------- -----GAGA-AATAAAAA-----------------TT-AAAACCATA-------AT---- ----GA---GATATCA---------TTAC----ACACCTATCAGAATGGCTAAAAT---A A--AAAATAG-----TGGCAAA-----AAGACA-AAAG--C------------------- ------TGGT-AAAGATGTA----------GAGAA------------------------- ------------ACTGGATCACTCAT-ACTCCGTTGG--TGGTAAG-------------- ----------ATTAT--A-------------AAAT---GTTCC----ACCAACTCTGA-- ------AAAGCATTT--TGATA----TTTTTT--TAAAAAAAAAAA--ACATACAAACCA TATAT---GA--CCCAAAAATTGTA---------------------CTTCTGTG-TATT- --------------TACCCCAGAGACA------T----GAA---ATTT----C------- ------------------------------ACGTGC---------ACGTAAATTCCTGTC AATTCATCTAGATAACTGAAAAATTATATACACAC-----AAAAACTGGAACAGAA---A TGTTTAT-----------------AGTAGCTTAGT--AAA-----TA------------- ---------A-------------------------------------------------- ------------------------TATCT----ATAACATGG------------------ ----TAA----AA----------------------AGGAACGAAGTATTTATACAG---- ------------------------------------------------------------ --------GCTGAAACGTGAATAAAT-C---TTCAGTGAATTTTTGTCAGTGA------- ------------------------------------------------AAACTACCAAGC AATA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAGTTA------------------------------ACAAACTCTTA-------- ----------ATAACATTCTT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------GAAA-------TGACAAA---------------ATT--------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------GAAATGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------ACAGATT------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTGGTT-----------------------------------------------G CCA-------GGGGTTAAGG-------AGGGGGTGGGGGTGGGAGGGAAGTGGGTGTG-- -------------------------------------------------GC--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TATAAAAGGGCA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ACATGAGGGATC--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------CTTGTGG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------TGATGGAAATG------------------------------ ---------------TTCTGTATCTTGACTGTATCAATGTCAGTATC------------- ------------------------------------------------------------ ----------------------------------------------------CTGGTTGT GATATTGT-ACTATAGT------------------------------------------- -------------------------TT-----------------TGCAAG---------- -------------------ATGTTACCATTGGGG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAAACTGGG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TAAAGGGTACGTGGGATCTCTCTGTATTATTTCTTACAACTGCATGTGAATC--TACA ATTATCTCAAAATAAAAAGTTTAATTTAAAA----------------------------- ------ >L1ME2 ------------------------------------------------------------ -------------------------------AAGAATGGAGCAGAAAAAATATTTGAAAA AATAATGGCTGAGAATTTTCAAAA-----------------ATTGATGAAAAAAATCAAC CCACAGATC--------------CAAGAAACTCAGAGAACCCCAAGGAAA---------- ---------------------------------------ATAAATACAAAGAAAACCACA CCTAGGCACATAATGTCAAACTGCTGAAAACCAAAGATAAAGA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------GAAAATATTAAA------AGCAGCCAGAG------------- AGAAAAGACAAAAACATTACATACAGAGAAACAT---------TGAAAAAAATTAATAGT TGCCTCCTTTTAAG---------------------------------------------- -------------------------------------------AAAAAATTAAGCCAAAA AACAAGTAAATAACATCTTTAAAGTGCTGAAAGG-----GA---AATATCAACCTAGAAT TCTATATCCAGCG---------------------------------------AAAATATC CTTCAAAAATGAAGGTGAAATAAAGACATTTTCAGATAAACAAAA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCTGAGAGAATTCATCACCAGAAGACATG CACTACAAAAACCACAAACAACCATAAAACTGGACAAAATATATGAATCATT-------- ------------------------------------------------------------ ------------------------------------------------------------ --GGTCATCTGCTGCTGAAAAAGAGGCAGAAA-------------AACAGATCTTACTCA GAAAATT----------------------------------------------------- ---------------------------------------GCAATGAGTTTAAGGGCACCT GA-------------TGATTTCTGTGGGGCTATGGCCAGAA------------------- ------------------------------------------------------------ ----CCCA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TCC-- ---------CCAGCTCTGGAATAAGAAATGAGTATGCAAAAGAAGAACTATGATCC---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TTTTTGAGGT-------AAAGAAAGTAGGGCCAAA----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------GCTAAACCCCCCTGAGGCACCAGTATTCTGGACAG------------------- ------------------------------------------------------------ --------------------------------------------CAGAAGACTGTCATCA GAGAGGCTTGGCCTTATATTCAGCAATATGTAGGATTG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AATCTCTAGATGAGTGGCGGG GAGACTGTGAAAGG---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------CGTCTAC CATAAAAAAGAGCACTCT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAAGTATAAGGAAGCAACGGCTAAGTGATTGAAAGC- ------------------------------------------------------------ ------------------------------------------------------------ --A-----------GAACTGTAGGACAAGGATTTAGTATGTGGATAAGG----------- ----------------------------------------------ATGTAAGA------ ---------------------------------------GTTATGACAAAA--------- ---------CAAAA---------------------------------------------- -GTAAGAAAATTTGACTATCGCCTTCCGAATAATTC------------------------ ------------------------------------------------------------ -------------------------------TAAGATAGCA------------------- ----------------------------------------GTAAC------------AAA GGTCCCTCGGGAGTTA-------------CTTC--CCCT--CAGA---AGTA-------- -------AAG----TCCACACCTTGGAGTTAGATCTACTCTGGAC-CAGCCTTAACCAAG CCAAAAC----CAAGCCCTGACGAGATCTTTAAAATTGAGAATTTG---GAGAT------ ------AAAA------------TATAATATTAGAGGAACTGAAGAAATGTCTTTGGTTTT CCACAGA----------------------------------TCAATCTAA--------AA ACAAACA----------------------------------------------------- --AAATAAA--------------------------------------------------- -GCCTACA----------CAATTTAAAGGGGGAAGCC----------------------- -------------------------------------------AAAACAAGCTCAAATAC ----------AAAC---------------TAGATACTAACTAAAC---------TTCCA- -ACA----TTAAA---------AAAAT---GATAAAAGAAGAGAATTATACATTTTAAGT CGGAATCTCCACATC-------------------ACTA--------------------CT CTCTATT------------------ACCAATAAGTTAT-A------AAAATCAATAT--- -AACATTAACAGAAACAGGCACACACAACTGC-------------AAATAAA---CTAAA AATA---ATAAAACCA-AA---------TGA---CCATAGAAAAA--AAAATTCATAGT- GCCCG--------AACACAGAGGG--CGCAAACATTGAA--CTTAACTGACACATA---- ----------ATAGAAA----------AAAAGTATGAAACAAATACT---------AAAA AATATCT---GAA----AGCAGTTATACAGT-ATATACATGTCTAGTATATATAGCACAG AAGTAAAAGAAAAAAAAACAGAGCAAT--ATCAAAATGCAAGAAAGGAAGAACAGAAA-A TTTGACGTAATAGATTCAGTGAATGAACTTAT--------------TAAGAAATTGGATC C----GGCA---------------------GAGCAGGAAATCAATAAATT---------- TAAAGACACGTCTATAAAAATGAGTCAAACT----------------------------- -------------GAAAAAA--AATGAAAAT---AAATAGAAAAAT-------------- -----------------AAAAAAGGG-AAAATT----------------TGATGCTAGGA TACATGATTTA---------CAGGA--AACA--------------CAGAAAAGGA----- -----------AGA-------------------------TCCT-------------GGAA GAAGG---------------AAATGATATAA--AAAAGAAA--------TTTAGATATAT TTG-AAATGTAAGGGCTCAAATACAT-----TTCAA-AAATAA-------GG-------- ------------------------T-GTAAATATAAACATATTCAGATAAAT-GAAAGCT GAGCTG-ATTCATCACCTAAATGC---CTGTATTAC-AAGAT------------------ --------------------ATGTTAAACAA----------------------------- ---------------------------------------------------CCATCTACA GGA---------------------------------------------------TAAAGA AAAACAATAT-------------------------------------------------- -------------------------------CAGGTGGCAATT----------------- ------------------------------------TAAATAT----------------- ----TTATATAGAAATGAAATAAATTGAAAAAAGGAAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GTTGATTGAAGGGATTTTCTTTCTCTCGTAAGTTAATGTAAAAATAATAAAATTAA AGGCAGGGTT-------------------------------------------------- -------AAAATGTATGTCGAGGTAAAGAAATAACAACAATGGTACAAGGAAACGCAAAG GGTTACATTTGTGAAGTGGGAACTGTGAAAAATATAGACAAAAGTAGAAAGATATTTTCT TATGAAGAGAGAGATGTAATG--------------------------------------- ------------------------------------------------------------ TGATAGATGTGAAG---TGCTATATGTGAAGTGGTATAATATTAACTCTA---------- --------AATA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CTGTGATGGTCAAAT--------------------TTAAA GATTACATATT---------------------------------------GTAATCTCTA GAGCAATCAC-CAAAAA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AAATAGAACG AAGAAGTAGAGCTCTTGTATAGCTAATAAGTCAATAGAAGAGATAAAATGGA-------- ------------------------------------------------------------ ---------------------ACCCTAAAAAATTTTATTTCACCTCAAAAAGTACAGGAA AAGGG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AGAACAAAT--------------------- ------------------------------------------------------------ ----------------------AAACAAAGATCAGATGGGACAAATAGAA-------AAC AAAT--TGCAA--GAATGTAGACTTATTT----------------AACAGAT-------- ------AGTCAG----ACTG---------GATCA-----AAAA---AAGCAAGACTCAA- ---CTA-------TTT-GCTA-----CATGAAATACATTT-TAAAT--ATAAAGACACAG A-TAGGTTGAAAGTAAAAGGA---T------------GAAAA------ATATATACAATA A--------------AAACAC------TAAGC---------------------ACAAG-A ATG-----GTGT----TGCTATATTAATATC-AGATAAGGTAGACTTCAAG-AC------ ----AAAGAATA---TTACCAAAGAT-AAAG-AGAGAAAT------TGTAT------AAT TATAAA---AGGGTCAATT------TATCAA---GAAG--------AC-ATAAATA-CCA AAA-----------------A----TATGTTTG---------CACCTAATAACAGAGCTT CAAA--ATA-CATGAAGCAAA-ATTGATAAAACT--AA----AGGGAAA---------CA TAGACAAATTC------ACAATTATTAGTGGAGATTTTAAAA----------------TC TCTCC------TCTAAT-----GATAAAATAA---------------------TAAGACA AAACAAAAC-------------AGTCAATGAATATA------------------------ -------------------AACTAATTGAAATTTAT---GA----ACAACCAATCTAACA AC---TGCAAAATACACAT------TTTTTTCAAGTG-----CA--CAT-GGAACATTCA --C----CAAGATAGATCATATGCTGGGCCATAAAACAAG-------------------- -TCTCAATAAATTTCAAAGGA--TTAAAAT----------------CATAA--------- -ATATGTTATTTGACAATCATAATAGAA-TCAAATTAGAAATCAAT-------------- ----------------------------------------------AACA--------AT --------------AAG-ATATATAG---AAAATTCCCCA----ATATTTGGAAA--T-T AAACAATACT-CTTCTAAA---TAACCCCATG--AGTAAAAGAAAA--AAC----AAAAA AGAAATT---------------AGAAAATATTTT---AAACT------------------ ------GAATGATAATAA-AAA------------CACAAC--ATATAAAAATTTG-GGG- AA-----TGCAACTAAAGAAGTC-----------------------------TTTAGAGG GAAA--TTTATAGCTTTA----AATGC----TTATATTAGAAAAA---AAGAAAGGTAT- --AAAATAAAT-GATCTAA-GTTTCCAACTT---AAGAAGC--TAGAAAAAG------AA GA-----ACAAATTAAAA-------------CCAAAAT--AAGAAAGA-AGAAAGAAATA ATA---AAAAATAAA-------------------ATAAAAAAA---AA---AAAA----- -----------AA------------------------------------AAA-------A ATAAAAAATCAAA--------ACA----AAGCCA-AAAGTTG------GTTCTTTGAAAA GATTAA------------------------------------------------------ --------------------------------TAA-----AATTG--AAACCT---CTAG CAA------GACTGA--TCA------------AGAAA------------------AAAAA A----AGAAAAAAAC-----------------AAATTAA--------CAATA-----TC- ---------AGA-AATGAAA--GA----------GGGGA---TATCACTACAGATCCT-A CA-GACATT--AAAAGGAT-AAT------------AAAATATT--ATGAA---------- -----------AAT---ATTTATGCTAATAA---ATTTGACAACTTAG---ATGAAAT-- GGACAAATTCCT----------TGAAAAA---------CAC-----AAATTACCA----- -AAACTAACACA---AAAAGAAATAGAAAATCTGAAT----------------------- AGCCT------------TA-TATCTATTAAAGAAATTGAAT-T---------TATAAT-- -TAAAAACCTTCC------CAAAAAGAAAAT---TCTAGGCCC--ATATGG--------- ------------TTTCACT-GGTG--AA-------------------TTCTA-------- ----TCAAACATTT---AAGAAA-GAAATAA--AA-CTAATA----------TTACAAAA ACTTTT----TC---AAAAAATAGAG------GAGAAG-GG-----------AAAATTTC CTAACTCATTTT-----ATAAAGTC-----AGCAT---AACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------AAGAA AAG---------------------GAA---------ATAAA---AGAAAATTAC------ -------------A-GATCAATAT---CTC----TCATGAACATAGAT------------ ------------ACAAAAATCC-TTA--------------------A----CAAAATATT AGC-AAATAA------------------AA--CC--------------CG--ACA----- --------ATATATA---------AAAAGGATAATACA--TCATGAC------------C AAG---TGAGG-TT----------TATCCCA------------GA--AAAGTAA-ATTGG -T----------------------TTAAAA-----ATTAAA--AAACCAATCAA--TGTA ---ATTCACCACAT------TAACAG----AATAAAGGAGAAAAAT---CATATGA---- -TCATCTCAATA---GATGC---AGAAAAAGAATTTGACAA---AATTCAACACCCATT- ---------------CATGA---------T---A--AA-----AACTCTCAGC---AAAC TAGAAATAGAAGGGAACT-----TCCTCAATCTGATAAA--------------------- ------GGGCATCTAT-AAAAAA--------CCTACAGC-----------TAACAT--CA TACTTAATGGTAA-----AATAATTAAATGC----TTTC---CCC----CT--AAGATTG GGAACA----AGGCAAGG-ATGT--TCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCTTCATTTCTATTC---AACATTGT ACT---GGAAGTCCTAGCCAGTGCAAT--------AAA-GC------AAGAA---AAAAA --AATAAAAGGCATAAAGATAGG----AAAGAA------GAAATAAAA--C--------- ------TGTCTGTA-TT--T---ACAGA------TGACAT------GATTGTTTACATA- -GAAAATC--CTAAGGA---ATCTACAA-------------------------AA--AAC TTCTAGAAAT---------AA--TAAGTGAATTTAGCAAGG--TTG-----CAGGATAC- --AA-------------------------------GGTCAA-------------TAT--- ATAAAAAT---------------------------------------------------- -----ACTATTTTTTTA-TATTGTAAC---------------AATAAAAAAA-----TAA A------------------AAATAAAATT-TTA----AAAACAATATTTTCTATAACATC T---------------------AAAAACATA---------AAA------TATTTAGGAAT AAATAT--------------AAAAGATATG---C---AAAACATCT---ACAC-TGAAAA CTATAAAATAT------TGATG-AGAGAAATTA-AA------------GAAG-------- ------------ACCT--AAAT--AAA---TGGA---GA--AATAT---------AGAGA TATACT-------ATG---TTGAAAAATTC-A---A---TATT--------------G-- TTAAGATG-----------------------------------------TCAAT--TCTC CCC-AA--ATTGATCTATA-------------------GA---TTCAATGCA---ATT-- ------C-CAATCAAAAT--C---------------------CCAGCA-GT---TTTTTT ------------------------------------------TGTAGAAATTG------- ----------------------ACAAGATGAT------TCTAAAA---TTTATATGGAAA T-------GCAAAGGACCTA---GA--ATAGCCAAAACAATTATAA------AAAA--GA ACA---AAGT--T-------GGA--AGACTTACA---CTACCTGATTTCAA--------- ----------------------------------------------GACTAA---GAT-A GCA--------------------------------------------------------- ---AATAAAT--CA---ATGG-AACAGAATAGAGAAACCAAATCAAG---AAATCAAA-- -CAAA----------------AAA-------TCTACAG----TCAATT--GATTTTT--- GACAAA--AGTACCAAGGAAATTC--A-------------------ATGGG--AA---AA GTAGAA--------TTTTTCTCTT--CAAAAAATTG---------------TACAG---- ------A-AAGAAC--TAG-CTAAACA---------------TAAGA-AAAAAA---ATG ---------TACCTTGAACTC---TAAAC-----------TTAACCCTATA------ACA AAAA-TTACTTGAAAAATGA---AT---CATAGAT---CTAAATATA--AAAGCTAAAAC TAT------------------------AAAACTTACAGAA---------------GAAAA ---CATA------GAA----------------GTTAAATATTTTTGTAACCTTCTTGGCG -----TAGGAAAAGATTT----TCTTAGACA--GAAAAGA---AAAAAAAAAACCAT--- --AAAAGAA---AA----AAA---TGATAAA-TTTGAC----------TTCATCAAA--- ATTAAAAA------------------ATTATCATA--------A--------------TT AAAAAACAACATT-------------AATAAAAATATAAAA------------------- ------A-------------TAACCC------ATTA----T-GGAAG---AAAG------ --ATGAGCCA---AT--------TC-------ACCAAAAAAT--------TG-------- ------AATAGAAAAA-AA-----------ATA------AA--CCAAT------------ ---AAA--------------AAATAAAAA---AAA--AACTAAAAATAA---AAAAAAAA AAAAAA---------ATA---------------AAACCATT------------------- ---------AAAAAA--------AATATACAATAATATTGGCAATTAAAGCATCAAAAAA AAT----------GCTCAACATCATTA-GTCATCA------------------------- -----GGGA-AATGCAAA-----------------TT-AAAACCACA-------GT---- ----AA---GATACTA---------CTAT----AAATTGACTAAATTGGGTAAAAT---A ATAAAAAA---------AGACA-----ATACTA-AATG---------------------- ------TGGTAAAGAATGGG----------AAGCA------------------------- ------------ACTGGAATTCCCAT-GCATTGTTGG--TGGG----------------- ----------GGTGT--A-------------AAAT---GGTAC----AACCACTTTGG-- ------AAAAC------TAGTA--AGTTTTTT--AAAAAGTTAAAA--ATACATTTACC- -ATAT---GA--CCCAGCAATTCAA---------------------CTTCTACC-TATT- --------------TA-CATAAAAAAA-----------AGAGAAATAA----AA------ --------------ATCTTTAAACAAAAAAACTTGT---------ACATG----ATTGTT GATA--CTATCTTTATTTATAA-TAACCACAAACT-----AG--AAAAAAACCCAA---A ATTTCAAC----ATAAGAG-----AATTGAAAAAA--AAAAT---TG------------- -----TGATT-------------------------------------------------- ------------------------TATTC----ATACAATGGAATAC-----T--ACTCA G---TAA----AA----------------------AAAAACAAACTAATAAAACTT---- ------------------------------------------------------------ --------------GCATGGATGAAT-C---TCAAAAATATGATGATGA----------- ---------------------------------------------------AGTTCTAGA ACAGGC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------------------------- ------------CTAATCTAT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------GTGATAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAA--------TCAGATC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTGGTC-----------------------------------------------G CCT-----------CTGGGG------------------GGGGGGGGGGAGCATGTGTG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTGAGATGAGTGTTAGATAGAAT TAAC-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------TGCAAAGGGGCA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------TGAGGGAACTTTCTGGGG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------TGATGGAAATG------------------------------ ---------------TTCTATATCTTGATTGTGGTGTTGGTTACACG------------- ------------------------------------------------------------ ------------------------------------------------------------ -GGTGTAT-ACATTTGT------------------------------------------- --------------------------------------------CAAAAC---------- ------------TCATCAAACTGTACACTTAAGATCTGT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GCATTTTAT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGTATG--TAAA TTATACCTCAATAA---------------------------------------------- ------ >L1ME3D ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------TTCAAAAATACA-------- ----------------------------------AAAAAAATAAAAAATAATGATT---- -TTAAAAAAAA------AAA---TATTTAAATGCATGTCTGAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------CTGGTGA----GAAAATAAAGAAA------ATTAATTGAAA-------GCCAGA AATGA-----------------------------------------AAAGAAAGGAAAAA TG---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CAGAAAGG TAAGCAACAATGAAACCATCATATATTCTGAGGGTATTAGCCAAATCATATTAACTTAAA TCTTAA------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------TTTTGAT AAGTTTTCATGATAAAAAAAATAAAAGAG-----------------------AAGGCTTA GGGTC------------------------------------------------------- --------------C------------GATAAAAGT---GAGGAAATAAATAAAACCTTA AA-------------------TAAAGCTGAAATCCCAAAAT------------------- ------------------------------------------------------------ ----CGAATAATAAATA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AAAAAAAAACTTCATG CAGA------GGAAAACAGAGTGACATAAAT----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TTCTACTAGGTATTAACAAAA ATAAATAATGGGGA--------------------------------AAAAAATTAATC-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------ATGAGACAA-----------TCAAAATCCAAAATAAA ------------------------------------------------------------ --------------------------TAATTTTTTAGGAAAATACAA------------- --A-----------TTATATAAATTGATTGGAAAAACAGAACCA---------------- ----------------------------------------------AATAAAAAAATT-- ---------------------------------------AAATTTAAATA---------- ------------------------------------------------------------ -GATAATTG-------------------ATGGATATCGTCTCT----------------- ------------------------------------------------------------ ---------------------------------AGAACAAC-----TCAAAAA------- ----------------------------------------GAAAATTTA--------AAT CAAA----TATTTATG-------------AACA--TAAT--TTAA---AAAA-------- -------AAA----AAAAAAAATA-------------------AAAAATAAAAAAGGAAA CAGAAAG----------------AAA---AAAGACAGCAAAAAATACAAACAGC------ ------AGAA-------TCAGTTATAAAAAACTCATAAATATAAAATATAAAT------- --AAATGAAAATAAA--------------------------AAAAAAAAATAT------- -TAAACT---------------------------------------------AAAAGTAT G-TAAAAGA--------------------------------------------------- -AGAAAAA----------GAAAGTCAAAAATTAAG------------------------- -------------------------------------------CAAACAAATTTGTAAAA ----------GAAC---------------ACAGTAG------AAG---------TTCTA- AAAA----TGGAA---------ACTAT------AATTGAAATTTAAATTTCAATGAAT-- ---GGATTTAACAGGAGA----------------TTCA--------------------GG A--CAGT------------------GAAAGAGAG-AAT-TAGTG--TACTTGAAGAT--- -AGAACTGAAGAAA-T-----TATCCAAACTGCAGTGCAAAAAAAAAAAAAATTAAAAAT AGGA--------AAGA-GA---------TGA---A--------------AAGATATAGAA AGATT--------AGAATGAAAAG--ATCTCACGTAAGT--G-TAATAAG--AGCT---- ----------CCAGAAGAAAATAAAAATAGAGAG---AATGGGCAAG---------AAGC AATATTT---GA-----AGAGATTATGGCT--AAGAATTTTCTAGAATT----------- ---------GCTGAAAGACAC--TAAA--CTTCAGATCC-----AGAAAGCCCAATAA-A TTCCAGGCA------------GAATAAA-TAT--------------AAAGAAAACCTCAC A-------T---------------------ACACACAAGATATCTAAATTTCAAACTGC- TGACAACGAAA---ATGAAG--AAAAAATATTTGAAAAAATTATGGCCAAATTTTCCCCA AATTTGGGGGAAATAAAAAT--AACTTCAGA---AAAAAGACAAAATTCCCCAAGAAAAT CACCACTCATAGGCATATTAAAAGAG-AAAAACAAAAAAAAAAAAAAATCTAGACT--GA TGGCTGACTATAAAGATCGGCTGAC--ATTAAAACATA-------CATTGAAGCACAG-- -----------GAG---ATTAA-T-------TTAATCAGTATT-------------CAAA GAAAAAATACAGTGTAATAAAAT-TTTTTCACCACCAAAAATAAAATTTTTT---TGTAC CCAAGAACAAATAGGGCAAAATAAGTATATGTTCAGAAAAAGA-------AA-------- ------------------------G----AATGAGAGTGTTTTT---CAAAT-AAAAGGA AATAGACCCTTACTAACGGCAGAT---CTGTACTATAAAGAA------------------ --------------------ATTCTAAAGGA----------------------------- -----------------------------------TATAC-------------TTCAGGA AGA--------------------------------AAGAAATCGTTGGAAGATCTAAATA AAAAGCTGAAAAATTTGAAAAAGAA----------------------------------- -------------------------------TTAGCAAGGGGAGG--------------- ------------------------------------ATAA-------------------- --------AAACAAATGAACAAAAATGTATAGAAAAGT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ATAATTTGTGAAGTTTAAAGAAAAAAGGAATAACAATCTAA CTAACGAGGA-------------------------------------------------- ------------------ATAATAGTATATAAGTTGGGA--------------------- --------------------GGGGAATAATTGAAGTTAAATTATTCTAAGGTCCTTGTAT TGTTTGGGAGGAGAGTAA------------------------------------------ ------------------------------------------------------------ ----------------------AAAAACTAATAAATTTATACTATATTAA---------- --------GAAT------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GC-------- --------------------TTGTTAAAATATCCATGGTAACCAC----------TAAAA TAAT----------------------------------------------AGAAATACAG AGTACAACAT-TCAAACTAGTAG------------------------------------- ---------------------AGAGAGAAAAT---------------------------- ------------------------------------------------------------ --------------------------------------------------GGAATGAGAA AAAAAATGAAAAAAAC-TTAAAAAAAACAACCAAATAGCAGGAAAAACAGGAAAA----- ------------------------------------------------------------ ---------------------GAATAAAGATAGA-------------------ACAAATA GAAAG------------------------------------------------------- ------------------------------------------------------------ -------------TAC----------ATAAGAAAA------------------------- ------------------TGGTA-------GAATTTAAT--------------------- ------------------------------------------------------------ --------------------TCAAAAAAGATCAAATAGTAA--AATAAAC-------G-C TAAA--GGAAA--AAACCC---TCCAGTT----------------AAAAATA------AA AGAT--TGTTAG----ACTA---------GATTTAT---ATAA---AACCACTAT----- ---TTGGTGCTGATAAATATTCATA-TAAGAATATCCTCT---AAC--ATAAGGACACAG A-AAGTTTGAAAGTAAAAGGA---T------------GAAAA----A-AGATATGCCAGG C--------------AAATAC------TAAC----------------------AAAAG-A AAGCTG--GTAT----AGCTATATTAATAAA-AGACAAAATAGACTTTAAG-GC------ ----AAAAAGTA---TTAGTAGAGAT-AAAG-AAGGTCAC------TACTT------AAT GATAAA---AGGTTTAATT------TACCAG---GAAG--------AT-ATAACAA-TTC TAA-----------------A----TTTCTATG-----------CCCAATAACATGGCTT TAAA--ATA-TATAAAGTAAAAATTGACAGAACT--AC----AAGGAGA---------AA TTGACAAATCC------ACAATCATAGTGGGAGATTTTAACA----------------CA ACTCCTTCAT-TTCAGA-AATTGATAGATGGA---------------------GCAGAC- ---AAAAAA-------------AATCAGTAAGGATATAGAAGACTTGAAC--------AG CA------TAAGCTTG---ATCTAATGGAAACACATACAGA----ACACTGCACTCAACA AT---TACAGAATACACAT------TCTTTTCAAGTA-----CA--CAT-GGAACATTTA --T----GAAAACTGACCACACTCTAGGCCATAAAGCAAA-------------------- -CCTCAACAAATTTCAAAAGA--TTGGTAT----------------CATATAGA------ -TCATATTCTCT---GACCACAATGCAA-TTAAGTTAGAAATCAAT-------------- ----------------------------------------------AACA--------GA --------------AAG-ATAACTAG----AAAAATCCAT----ATATTTGGAAT----T AAAAAATACA-CTTCTAAA---CA-GCTCATG--GATAAAATAAGA--AAT--------- ---AACT---------------AAAAAAAATTTA---AAACT------------------ ------GAATGATAATGA-AAA------------TACTAC--ATATCAAAACTTG-TGG- GA-----TTCAGATAAAGTAGTA-----------------------------CTTAGAGG GAAA--TTTATAGCCTTA----AATGC----TTACATTCAAAAGG---AAGAAAGGCTT- --AAAATTAAT-GAGCTAA-GCATCTATCTT---AAGAAGT--CAGGAAAA-------AA CA-----GCAAAATAAAC-------------CCAAAGA--AAGTAGAA-GAAAGAAAATA ATA---AAGATAAGA-------------------ACAGAAATT---AA-T-GAAATAGAA AACAA------AC------------------------------------ATA-CAA---T AGAAAGGATT-A---------ACA----AAGTCA-AAAGTTA------GTTCTTT-AAAA GACTAA------------------------------------------------------ --------------------------------TAA-----AATTAATAAACCT---CTGG CAA------GACTGA--TTAAAAAA-------AGAAA------------------AAAAG A---GAGA-AAGCAC-----------------AAATAAG--------CAATA-----TT- ---------AGG-AATGGAA--AA----------AAGGA---CATAACTACAGATGCT-G AA-GAGATT--AAAAAGAT----AAG---------AGAAGGTT--AT-AA---------- -----------CAA---CTTTATGCCAAAAAA--ATTTGAAAATTTAG---ATGAAAT-- GGACAAATTCTT----------AGAAAAA---------TATAACTAAACTTATCA----- -AAACTGACTCA---AGAAGAAATAGAAAACCTGAAT----------------------- AGTCT------------TA-TAACCATTAGTAAAATTAAAT-C---------AGTGGT-- -TAAAAATCTTCC------CACAAAGAAAAC---TCCAAGCCC--AGATGG--------- ------------CTTTATA-GGTG--AG-------------------TTCTA-------- ----CCAAACATTC---AAGGAA-CAAACAA--TT-CCAATC----------TTACACAA ACTCTT----CC---AGAGAA---AA------GAAAAG-GA-----------AATACTCT CCAACTCATTTT-----ATGAGGCT-----AGCAT---AACCTTG-ATAC---------- ----------------------------------------C--AAAAT-------CAGAC AAG---------------------GAC---AGTACAAGAAA---GGAAAATTAT------ -------------A-GGCCAATCT---CTCCTAATCATGAACATAGTT------------ ------------CCAAAAATTC-TAA--------------------A----CAAAATATT AGC-AAACCA------------------AA--TC--------------CA--GCA----- --------ATGTTT----------AAAAAGATAATACA--TCATAAC------------C AAG---TTGGG-TT----------TATCCCA------------GG--AATGCAAGGTTGG -C----------------------TT-AAT-----ATTAGA--AAATCAATTAA--TGCA ---ATTCATCACAT------TAACAG----ATTAAAGGAGAAAAAC---CATATGA---- -TCATCTCAATA---GATTC---AGGAAAAGCATTTGATAA---AATTCAACATCCATT- ---------------CATGA---------T---A--AA-----AACTCTTAGC---AAAC TAGGAATAGAAGGAAACT-----TCTTTAACCTGATAAA--------------------- ------GGGTATCTACAAAAAAA--------TTTACAGC-----------AAACAT--CA TACTTAATGGTGA-----AAC-GTTGAAAGC----ATTC---CCT----TT--GAGATCA GGAACA----AGACAAGG-ATGT--CCATTA----------------------------- ------------------------------------------------------------ ----------------------------------CCATCACTTCTATTC---AACATTGT ACT---GGAGATCCTAGCCAGTGCAGT--------AAG-AC------AAGAAAAAAAAAA ATAATAAAAGGTATAAAGATTGGG---AATGAA------GAAACAAAA--C--------- ------TGTCATTATTT--T---ATAGA------TAATAT------GATTGTATACATA- -GAAAACC--CAAAAGA---ATATACAG---------A---------------TA--AAT TATTAGAATT---------AA--TAAGTGAGTTTAGCAAGA--TTG-----CTGGATAC- --AA-------------------------------AATCAA-------------TAT--- ACAAAAGT----CAAT-------------------------------------------- -----TTCATTTCCACATTACACCAAC---------------AGT------------TAG A------------------AAATATAATTTTAA----AAAA-----CCATTTACAATAGC AAC-------------------AAAAAAAAA---------AAA------TACCTAGGAAT AAATTT--------AA--AACAAAGATATG-------TAAATCTTTTAGGAGA-AATCAA TTAAAAAATTT------TATTG-AAAGACATTAAAA------------AACT-------- ------------AAAT---AAT--AAA---TAGA---GA--GATAT---------ACCA- --TGTTC------ATG-GATAGGAAGACTC-A---A---TATT--------------A-- TAAAGATA-----------------------------------------ACAAT------ CCTCAA--ATTGATCTATA-------------------GA---TTCAATGCA---ATT-- ------C-CAATAAAAAT--C---------------------CCAACA-GG---ATTTTT ------------------------------------------CATAGAACTTG------- ----------------------ACAAGCTGAT------TCTAAAA--ATTTATATGTAAG A-------GCAAAGGGCCAA---GA--ATAGCCAAGACGCTCTTGACGA---AAAA--AA A-----AAAT--G-------GGA--AGACTTGTC---CTACCAGATATCAAGAT-----T TATTAT-------------------------AA---AGCTATAGT-AATTAA---GAA-A GTG--------------TGGTATTGG--CG------------C---AGGGATAGACA--- ---AATAAGC--CA---ATGG-AACAGAATAGAGAGCCC------AG---AAACAGAT-- -CCAT----------------GCA-------TATATGA----AAACTT--GATTTAT--- GACAGA--GCTGGCATTGCAGAAC--T-------------------ATGGG--GA---AA GG------------ATAGACTTTT--CAATAAATGA---------------TGCTT---- ------G-GACTAT--TTATGTTTCCA---------------TATG--GGGAGAAAAATA ---------AAATTGGATCCC----CTCT-----------TTCAAGAAACA--C---ACA TAAAATCAATT-CCAGGTGG---AT---TAAAGAC---TTAAA-ATA--AAATTTGAAA- TTT-----------------------------------AA---------------GAAAC ---TATA------G------------------G-AGAATATCTTTATGACCTCG--GGG- -----TAGGGAAAATTT-----TCTTAAACAA-CACACAA---AAAGACTCCACAT---- --AAAGGAA---AA----TAT---TGATAAA-TTCGAC----------TACATT-AA--- AATTAAAA-----A------------CTT-CTGTT-------CA--------------TC ---AAGAGACAAC-------------AAAGAG-GCAAAAAG------------------- ------A-------------CAAGCC------ACAAAC--T-GGGGG---AAGATATTT- --GCAACACATATAA--------CA-------AACAAAGGAC--------TA--GTATC- ---CAGAATATATAAA-----AATCCT---ATA------AA--TCAAT------------ ---AAG--------------AA--AAACA---------ACTTTA-TAGA---AAAATAGG ---------------AGA--CAAAACACAC---AAACATTT------------------- -----CACAGAAGAG--------GAAACAC---AA-ATGGCTCAT--AAACACATGAAAA GAT----------GCTCAACCTCATTA-GTAATCA------------------------- -----GGAA-AATGTAAA-----------------TT-AAAATTACA--------T---- ----GA---GATACTA---------TTTC----ATACCCGCCAGATTGGCAAAACT---T A--AAAAA-------TTTTACA-----ATATCA-AGTG--T------------------- ------TGGC-AAGGATGTA----------GAGCC------------------------- ------------ATGGAAATTCTCAT-GCACTGCTGG--TGGG---AGAATA-------- ------AGTTAATGT--A-------------AATT---GGTAC----AATCACTTTGG-- ------AAAACTATT--TGGC---ATTACCTA--GTAAAGTTGAAC--ATGCAAATTCCC CAT-----GA--CCCAGCAATTCCA---------------------TTCCTAGG-TATA- --------------TACCTTAGAGAAA-----------------CTCT----TACA---- --------------CATGTGCACCAGA-AGACATGT---------ACAAA----AATGTT CATA--GCAGCATTGTTTATAA-TAGCCCAAAACT--G--GA--AGCA--ACTCAA---A TATCCATCA---ACAATAG-----AAT-GATAAAC--AAAT----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATTC----ATACAATGGAATAC-----T--ATACA GAAGTAA----AA----------------------ATGACTGAACTACAGCTACAT---- ------------------------------------------------------------ --------GCATCAGCATGGATGAAT-C---TCAAAAACATTACGTAGAGGAG------- -------------------------------------------------AAAAGCAAGTC ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AACA---------------------------------ATACATAC-AG-------- ---TAT---GATTCCATTTAT------ATAAAGTTCAAAACCAGGC-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAC-------TAAACAATACATTGTTTGGGGATAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TATATAGGT GGTAAAACTATAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGAAAAGCA--AAGGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----GATTAAT-----------------------------------------------A CAAAATTC--AGGATTGTGGTTACCTTGAGGAGGGGAATGTGGCTAGCTTTGATAGGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TGGTCATACAGGGA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------GCTTCGAGGGTA-------------CT GATAATGTTC-------------------------------------------------- ------------------------------------------------------------ ------------TATTTCTTAAGCT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GGGTGGTAGGT------------------------------ ---------------ACATGGATGTTCAGTTTATTATTATTCTTTAA------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACTATAT-TTACATAC------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ACTCTTAAT-------------------------TT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GCATATGTACACGTTTCATATATTTTTGTATATA--TGAT ATATTTCACAATAAAATA------------------------------------------ ------ >L1MD2 ------------------------------------------------------------ ------------------------------------------------TTTAAAAAGAAA TAAAGGCTTCCACTTCTGGCCAAG-----------------ATGGAGTAACAGAGACCAA TTTACTCTC--------------------ATGCTTGAAACAACCAAAAAAAC-------- ----------------------------------AGACAAAATATATGAAACAATGGTTT TTAAGACACTGGATATCAGGCAATGAAGGGCAGTGATCTCTCA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------ATGATGGTAAACAAATTAGGTAAGTCCTGCGATTGCTCCAGCTTACCTCCTTGA GAGAGTTTCCAGGCTGTGGTGCAGGGA------------------GGAAACTGGGCAGAG CCTGGCAAGTTCCC----------TGAGTTG--------------AGGAGATGAGCTTTG AAT-------------------------------------CGGGAAGACCAAGACAGAGT TTATACAACAGAGTACCAACAAGGAGAAAACTGC-----AC---AAAGAAAGCCGAAGAC CTGCAGAGGGTCCCCT------------------------------------TGGAGTAT CCAGCAGAGTACTGATCAGTACATGCATGTGAGAAAACCACCCATTGCCAG--------- ---------------------------------------------GAAAAGAACTCCTCA AAAGGATTAGAGAGA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------AGAGTACCC----GGCACTCACAAA GAGTGGGGAATAATGCCTGTTCCCACAAACCAAACTGGAAAACCTCACAATTTACAGGGC TTTGGGTAGAGTGCTA-------------------------------------------- ----------------------------------------------------GGAAAGTC TTGCCTCAATAATGGGGAATAATTAGCCCCAG-------------TCTAAACACAACTCT GGCCC------------------------------------------------------- -------TGCCTAAC------------AAATCTTAA---AAGCAAGACCCAGAAGGATCA AA-------------------CTGTTTCCAAGTAACTTAAA------------------- ------------------------------------------------------------ ----TGCAA--------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------CCC-- ---------AGAACAAAGCTTAAGAATGTTTACATAAATACAAAAATTTCCAGTACCCAA CAAGGTAAAA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------TTCACAATGT-------CTGGCATCCAATCAAAAATTAGC AGCAAGGAAAGAAGGAG------------------------------------------- ------------------------------------------------------------ -------------------------------------------GAAAATATAACCCATAA AAAAG-GAGCAAAATCAATCAATC------------------------------------ ------------------------------------------------------------ -------------------------------------------------AAACCATCCCA GAATTGACACAGATGTTGAATTAGCAGACAAAGACATTAAAACAGTT------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TTTATAATTGTATTTCATGTG TTCAAAAAGTGAAG---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TAGAGACATGGAAGATATATTTTAAAAAAGAAC CAAATCAAACTTCTAAAAATAAAAACTTTAATATC----CAAGATAAAAAATCCCCTGGA CGGGATTAGTAACAGATTAGCTATTGCAG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AAGAAAATA-----------TTAGTCAACTAAAAGAT ------------------------------------------------------------ --------------ATACTAATAGAAAGATCCAAAATGAAATACAGA------------- --G-----------AGATATAGAATTAAAAATTAAAAAGACAAA---------------- ----------------------------------------------GTATCAGTTAGCTG TGACACAACTTCAGTTGGCCTAATATACATGTAATTTGAGTTCCTGAAGAT--------- ---------GGGAGGGGGT----------------------------------------- -GGAGAGAAAATACTAA------------------------------------------- ------------------------------------------------------------ -------------------------------AGGGGAAAAA-----ACAGAGCAGAAAAA CTG-------------------------------------GAAACTCTA--------AAA ATCA----GAGCACCT-------------CTCC--TCCT--CCAA---A-GG-------- -------AAC----GCACCTCCTC-------------------AC-CAG---CAATGGAA CAAAGCT----GA------ATGGAGA---ATGACTTTGACGAGTTGAGAGAGGA------ ------AGGC------------TTCAGAATAA--------ACAAAGTCTTAGGGATCT-- ------GTGGAAACT--------------------------CTAATTCAAGATTTATGAA AGAAGTT---------------------------------------------AAAAACCT T-GAAAAAA--------------------------------------------------- -AATTAGA----------TGAATGGCTAACTAGA-------------------------- -------------------------------------------ATAACCAATGCAGAGAA ----------GTCC---------------TTAAAGG------ACC---------TAATG- GAGG----TGAAA---------ACCAC---GGCACGAGAACTATGTGATGAATGCACA-- ---AGCCTCAGTAGCCAA----------------TGCA--------------------AT C--AACT------------------GGAAGAAAG-GCT-ATCAG--TGATGGAAGAC--- -TAAATGAATGAAC-T-----AACAGAGTCCC---------AGAAGGAGAGA---AGAAA GAGA---ATAAAAAGA-AA---------CAA---ACAAAGCCTTC--AAGAACTAAATA- TATAT--------G---TAAAA----TCTGAGTTCCTGAAGT-TGGGAGG--TGTT---- ----------ACTGAAAAAGATGGGGAGAATGGA---ACCAACTTGG---------AAAA AATACTA---GT-----TGAAATAATGGCT--AAGAATTTTCCAAATTT----------- ---------GGCAAAAGACAC--AAAC--CTAAATATAC---ATAAAAAACCTAAAAA-A CCACAAAGAT-----------AAAACAA-CAA--------------AAGAAATGCTACCC A-------A---------------------AGACACATCATAATCAAACT------TTT- GAAAACTAAAA---TTAAAA--AAAAAATCT----------------------------- -------------TAAAAAC--AGCCAGAGA---GAAAAAACACAT-------------- -----------TAT---TTATAGAGG-AACAACAA--------------TTAAAAT--GA CAGCAGATTTC-----TCATCAGAA--ACCATA-GATGC------CAG-AAGAGAGTG-- -----------GAG-CAGAATA-T-------TTAAAA--TATT-------------GAAA GAAAA---------------AAATTT--AAA--TCCCAAAA--------ATT---AATAT TCA-----------TTAAAAAAAACC-----TTCGT-GAATGA-------AG-------- ------------------------G-TGAAATAAAAACATTCTCAGATAAAA-AAAAACT AAGAGA-ATTTATTACTAGCAGAC---CTGTTCTAA-AAGAA------------------ --------------------CTCCTAAAGGA----------------------------- -----------------------------------AGTCC--------------TCAACA TGG----------------------------------------------------AAAGG AACA---------------ACCGGTA---------------------------------- -------------------------------CCAGCCACTGCA----------------- ------------------------------------AAAACAT----------------- --------GCCAAATTGATAAAAATTATACCGAATGGA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AATATGGAACTACACAAAGGAATGAAGAAC ACTGGAAATG-------------------------------------------------- ------------------------GTAACTACATGGGTAAATACAAAATACTTTCTCTCA TTATTTAAATGTCTATAAAAGATAATTGACTTAAACAAAAATAGTGTAGTATGGTGGTTA TAA--------------------------------------------------------- ------------------------------------------------------------ --CATAGGTACTAG---TTACCCATGAGAACTAGTGTGATATCACTTGAA---------- --------GATA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CTGTGGTAAG-------------------------TTAAA GATATATACTATAAACCCTAAA----------------------------GCAACCGCTA AAATAACCCA-AAAATTATAGCTGATAGACC----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AACAAAAGAG ATGAAATAGAATTATG-AAAAATAATCAAAAAGAGACGCAAAAAAAGGAAGAGAGTGAAC TAAGAACAGATA------------------------------------------------ ---------------------GGACAAACGAAAA-------------------ACAAACA TCAAG------------------------------------------------------- ------------------------------------------------------------ ATTATAATTTAGTCATAATTATATTAAATATAAAGTCTAAACACCCAATTAAAAGGTAGA GATTGTCAAATTGGATAAATACA-------GAATCAAAT--------------------- ------------------------------------------------------------ --------------------ATAAAAATA--ACAATAATAAA-ATTAAAT-------A-T AAAT--GGGCT--AAATAC---TTCAATT----------------ATAAAAC------AC AGAT--TGGCAA----AATG---------GATT-------------AAAAAGAACCCAA- ---CAA-------TGT-TTTGTTTA-GAAGAAATTCATTT-CAAAT--GTAATGATATAG A-TAGGTTAAAAGTAAAAGGA---T------------GGAAA----A-ATATATACCATG C--------------AAAAAT------TAATC---------------------AAAAA-A AAGCAG--GAGT----GGCTATATTAATATC-AGATAAAATAGATTTTAAA-GC------ ----AACGAAAA---TAAACAGAGAC-AAAA-AAGGACAT------TACAT------AAT AATAAA---AGGATCAATT------CACCAA---AAAG--------AT-ATAACTA-TCA TAA-----------------A----TATATATG---------TAACCAACAAAGGAGCA- --AA--ATT-CATTGAACCAAAAATAATAGAAAT--AA----AAAGAGA---------AA TAGACAAATAT------ACAATTATAGTTGGAGACTTCAACA----------------CC CTTTT------CTCAAC-AATTGACAAAATAA---------------------CTAGAC- -----AGAA-------------AATCAGCAAG---ATAAAAGAACTGAAA-AACACAATC AA------CCAACAAG---ATCTAATTGATATATATA--GA----ATACTCCACCCAACA AC---AGCAGAATACACAT------TCTTTTCAAATC-----CA--CAT-AAAACATTCA --C----CAAGATAGACCATATCCTGGTCCATAAAATAAA-------------------- -CCTCAACAAATTTAAAAGAA--TTGAAAT----------------CATACAAA------ -GTATGTTCTCT---GACCACAATGGAA-TCAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------GA --------------AAG-ATAACAAG---AAAAACCTCAA----ACACTTGGAAA--T-T AAACAACACA-CTTCTAAA---TA-ATCCA----AGTGAAAAAGGAAAAAT--C-AAAGG AAATATT---------------AAAATATACATT---GAAAT------------------ ------GAATGAAAATAA-AAA------------TACAAC--ATATCAAAAAATG-TGG- GA-----TACAGCTAAAGCAATG-----------------------------CTGAGAGG GAAA--TTTATAGCATTA----AATGT----TTTAATTAGAAAAG---AAAAAAAATCT- --AAAATCAAT-AATCTAA-ATTCCCACCTA---AAGAAAC--TAAAAAAAA------AA GA-----ACAAAATAAAC-------------CAAAAGA--AAGAAGAA-GAAAGAAAATA ATA---AAAATAAAA-------------------ACAAAAATA---AA-T-GAAATTAAA AAAAA------AA------------------------------------AAA-CAA---T AGAAAAAATC-A---------ATG----AAACAA-AAAGCTG------GTTCTTTGAAAA TATCAA------------------------------------------------------ --------------------------------TAA-----AATTGATAAACCT---CTAG CAA------GACTGA--CAA------------AAAAA------------------AAA-- ----AAGA-AGATAC-----------------AAATTAC--------TAATA-----TC- ---------AGA-AATGAAA--CA----------GGAGA---TATCACTACAGATCCT-G TA-GACATT--AAAAGGAT-AATAAA---------AGAATACT--ACAAA---------- -----------CAA---CTCTACACACATAA---ATTTGACAACTTAG---ATGAAAT-- GGACCAATTCCT----------TAAAAAG---------CAC-----AAACTACCA----- -AAACTCAACCA---ATATGAAATAGATAATCTGAAT----------------------- AGCCC------------TA-TAACCATTAAAGAAATTGAAT-T---------TATAAT-- -TAATAAAATACC------TACAAAAAAAAATCTCCCAACTCC--AAAAGG--------- ------------TTTTCCAGGGAA--AT-------------------TTTTA-------- ----CAAAACTTTT---AAAAAA-AAATAAA--CA-TAAATT------------TTAAAA ACTTTTT---CC---AAGAAAATAAA------AGAGAG-GA-----------AATCTTTC CAAATTCTTTTA-----TTAAAGCC-----AAAAA---TTTCCTG-ATAA---------- ----------------------------------------C--AAAAA-------AAAAA AAA---------------------AAA---ACAAAAAAAAA---AAAAAAATTA------ -------------A-AAACAATAT---CTC----TCATGAATATAGAT------------ ------------ACAAAAATCC-TCA--------------------A----CAAAATATT AGC-AAATAA------------------AA------------------TAAAACA----- --------ATATATA---------AAAAAATTTATACA-----TAAC------------C AAG---TGGGATTT----------TTTCCCA------------GG--AATGAAAGACTGT ------------------------TT-AAA-----TTTTAA--AAAATAATCAA--TGTA ---ATTCACCATAT------CAACAA----GCTAAAGAAGAAAAAT---CATATGA---- -TCATATCAATT---AATGC---AGAAAAAGCATTTGACAA---AATTCAACACACATA- ---------------TAAAA---------T---A--AA-----AACTCTTAGA---AAAA TAGGAATAGAAGGGAACT-----TTCTCAACTTGATAAA--------------------- ------GAACATGTAC-AAAAAA--------ATCACAGC-----------TAACAT--TA TACTTAATGGTGA-----AAA-ACTGAATTC----TTTT---CCC----CT--AAAATTA AGAACA----AAGAAAAG-ATGT--CCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCATTCCTATTC---AAAATAGT ACT---AGAAGTAATTGCTATTAAAAT--------AAG-TA------AAGAA---AAAAA --AATAAATAAAAAACAAATTGAAAAGAAAGAA------AAAATAAAA--T--------- ------TGTTCCTA-TT--T---ACAGA------TGACAT------GATGGTCTACATA- -AAAAATC--TAAAAAA---ATTAATAAAAAACATAAA---------------AA--AAA TAATAAAACT---------AA--TAAGTGAGTTCAGCAAGG--TTA-----CAGGATAC- --AA-------------------------------GATCAA-------------CAT--- ACAAAAAT----CAAT-------------------------------------------- -----TACATTTC--TA-TATACTAAC---------------AATGAACATA-----TGG A------------------AACAAAAATT-AAA----AATATAATACCATTTACAATCAC TCCA------------------AAAAAAATG---------AAA------TACTTAGGTAT AAATTT--------AA--C-AAAAAAAATT---ATGGAATTTTTAT---GTTA-TGAAAA TTACAAAATAC------TGATG-AAAGAAATCA-AA------------GAAG-------- ------------ACCT--AAAT--AAA---TGGA---GA--GACAT---------ACCA- --TGTTC------ATG-GAATAGAAGACTC-A---A---CATA--------------G-- TAAAGATG-----------------------------------------TCAAT--TCTC CCC-AA--ATTAATATATA-------------------GA---TTTAATACA---ATT-- ------C-CTATCAAAAT--C---------------------CCAGCA-AG---ATTTTT ------------------------------------------TGCAGATATAG------- ----------------------ACAAACTTAT------TCTAAAA---TTTATATGGAAA G-------GCAAAGGAACTA---GA--ATAGCTAAAACAATCTTGAAAA---AGAA--AA ATA---AAAT--A-------GGA--GGAATCACT---CTACCTAATGTTAAGAC-----T TACTAT-------------------------AT---AGCTACAGT-AATCAA---AAC-A ATG--------------TTGTATGGG--TA------------G---AGGGATAGACA--- ---CATAGAT--CA---ATGG-AACAGAATAAAGAACTT------AG---AAATAGAA-- -AAAA----------------AGA-------TATTTAGTATACTAAATATAAACTTT--- GACAAAAAAATAAATCAAAGAAAA----------------------ATAAAAAAG---AA AA------------ACAGTGTTTTTAAAAAAAATAG---------------TTCTG---- ------G-AATATCTGTAA-ATA-------------------TATAT-AGAAAA---AAA ACAAACATTGATTTAGATCTA---ACTTT-----------AAAACT--TTA--T---ACA AAAA-TAAACA-CAAAATGG---AT---CATAGAC---TTAAATGTA--AAACCTAAAAC CAA-----------------------TAAAATTTTTAGAA---------------AAAAA ----ATA------A------------------G-AGAAAATCTTTAGGAACTAG--GCT- -----TAGGCAAAGAAT-----TCCTAACATT-AAAACCA---AAATCTTCAGCAAT--- --AAAAGAA---AA----ACT----TATAAA-TTAGAC----------CTCACCACA--- ATTTAAAA------------------CTTTGTTCTGTGAAAGCACACTAAAGAAGATGAC -AAAAGACATAATATT----------CATAAAAATAAAAAGCTTTTTCAATATGAGAAAA ACTAATAAAATAATAAAAGTCAA---------AAAAAACCTAGTAAG---AAAATTGTC- --ACAAGCTACATAT--------CT-------GACAAAGAAC--------TGGTATGTC- ---AATAACATAAAAC-AA--ACTGA----ACATTTAAAAA--TCAAA------------ --------------------AATAAAACA---AAC--GTCACGA-TTAA---AAAATGGG C--CAA---------GGA--TATGA---AC---AGACATTT------------------- -----CACTGAAGAG--------GATATAC---AG-ATGACAAAT--AAGCACATGAAAA GAT----------GTTCAATATCATTA-GCCATTA------------------------- -----GGAA-AATGCAAA-----------------TT-AAAACCACA-------AT---- ----GA---GATATCA---------CTAC----ACACCTATTAGAATGGCTAAAAT---A AAAAAAAT-------AGAAAAA-----ACAACA-AATG--C------------------- ------TGGG-GATGATGAG----------GAAAA------------------------- ------------AGTTGATCACAT---ACATTTCTGG--TGGGAAATGGCTCTCTACTCA AAATGTTGGTAATCTCAAATTGTAGAAAAAAAAAT---AATAC----AACCACAATGT-- ------AAAAAAGTT--TTTAA--ATATCTTT--TAAAAATAAAAC--ATATATTTACA- -------------------------------------------------TTAGGCAATA- --------------TATCACAGAAAGA-----------TGAAAAAT-------------- --------------TCCATTCAC-ACAAAAATTTGT---------ACAAA-----ATTAT TATT--AGAACTTTATTTATAA-TAGCTAAAAAAT--T--GATATTTA----CAAA---A AGTGCCTCA---AATCAAG-----AATGGTTAAAA--AAAC----TG------------- -----TGGTA-------------------------------------------------- ------------------------CCTCC----ACAGCGTGTAACAC------------- ----TCA----AA----------------------------------------------- ------------------------------------------------------------ --------TCAATAACATTCTTGAAA-----TGAC------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------------------------- -----------------TTAT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------A-- ------------------------------------------------------------ ------------------------------------------------------------ ------GAGATGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------ACAGATT------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTGGTT-----------------------------------------------G CCA-------GGGGTTAGGG-------------ATGGGGGGGGGAGGGGGTGGGTGTG-- -------------------------------------------------GC--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TATAAAAGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------GCACGAGGGATCCTTGTGG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------TGATGGAACAG------------------------------ ---------------TTCTGTATCTTGACTGTGGTGGTGGTTACACG------------- ------------------------------------------------------------ ------------------------------------------------------------ ---AATCT-ACACATGT------------------------------------------- --------------------------------------------GATAAA---------- ---------ATTGCATAGAACTATACACACACACACACACACACACACAGATGAGTGCAA GTAAAACTGGTGAAATCTGAATAAGATCTGTGGATTGTACC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AATGTCAATTTCCTGGTTGTGATATTGTACTATAGT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TATGCAAGATGTTACCATTGGGGGAAACTG GGTGAAGGGTACATGGGACCTCCCTGTACTATTTCTTGCAACTTCCTGTGAATC--TATA ATTATTTCAAAATAAAAAGTTTATTAA--------------------------------- ------ >L1ME2Z ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ATGAGGAAAAA-----CAAGTGC--AAA-- -----AATGCT---------------------------G-AAAATTCCA--------AAA ACCA----GAATGCCT-------------CTTT--TCCT--CCAA---A-TG-------- -------AGT----GCAACTCCTC-------------------TC-CAG---CAAGGGCA CAAAACT----GG------ACTGAGA---ATGAGTTTGACAAATTGACAGAAGT------ ------AGGC------------TTCAGGAGGTGAGT-AATAACAAACTCCTCTGAGCT-- --AGAGGAGCATGTT--------------------------CTAACCCAATGC-----AA GGAAGCT---------------------------------------------AAGAACCT T-GATAAAA--------------------------------------------------- -GGTTACA----------GGAACTGCTAACTAGA-------------------------- -------------------------------------------ATAACCAGTTTAGAGAA ----------GAAC---------------ATGAATG------AAC---------TGATG- GAGC----TGAAA---------AACAC---AGCACGAGAACTTCATGAAGCATACACA-- ---AGTATCAATAGCCAA----------------ATCA--------------------AT C--AAAC------------------GAAAGAAAG-GAT-ATCAG--AGATTGAAAAT--- -CAACTTAATGAAA-T-----AAAGCATGAAG----------CAAGATTAAAG--AAAAA AAGA---ATGAAAAGG-AA---------TGA---ACAAAGCCTCC--AAGAAATATGGG- ACTAT--------G---TGAAAAG--ACCAAACCTATGA--T-CGATTGG--TGTA---- ----------CCTGAAAGTGATGGGGAGAATAAA---ACCAAGTTGG---------AAAA TACACTT---CA-----GGATATTATTCAG--GAGAACATCCCCAAACT----------- ---------AGCAAGACAGGC--CAAC--ATTCAAATTC-----AGGAAATACAGAGA-A CACCAAGAA------------AAAACAA-CAC--------------AAAAAAAACAACAC C-------A---------------------AGAAACATAATCATCAGATT------CTC- CAAGGCTGAAA---TGAAGG--AAAGAATGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGCCAGGT-------------- -----------TAC---CTATAAAGG-GAAGCCCA--------------TCAGACT--AA CAGTGGATCTC-----TCTGTAGAA--ACCCTA-CAAGC------CAG-AAGAGAGTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA-------------A-AAT-TT--TCA--ATGCAGAA--------TTT---CATAT CCG-----------GCCAACCTAAGC-----TTCAT-AAGCAA-------AG-------- ------------------------G-AGAAATAAAATTCTTTACAGACAAGC-AAGTGCT GAGGGATTTTTGTCACCACCAGGC---CTGCCTTAC--AAAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCAC--------------TAAATA TGG----------------------------------------------------AAAAG AAAA---------------ACCAGTA---------------------------------- -------------------------------CCAGCCACTGCA----------------- ------------------------------------AAAACA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TACCA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAATAAAAATGAA--------------AA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TAGTGCATA--TAAA-----AT-TTTATAT-------GAA GGCT--GGAGT--AAGTAT---AATAGTT----------------AAA------------ -----------------------------GAT-------AAAA---TAATGA---TCAA- -------------AAT----------TAGAAAAT--ACTT-TGAAC--TGAATGATACTA A----------------------------------------------------------- ---------------AAATAG------T-------------------------AAAAG-- ----------------TGTTATAC--------------AATATACTTAATT--------- ---------------TAGAAA------AATG-GGGGAAAT------TATTT------AAT --TAAA----TGCTTACCT------TGGAAAACTGAGG--------AC--TGAGAA-TGA T-------------------A----TAATTTTG---------CAT--------------- ------GTT-AATAAGATAAA---------------AA----AAAAAGA----------- ---------GC------ACATTAA------------------------------------ -----------ATCCAA-AGTAAGTAGAAGAA---------------------------- -----AGGA-------------AAT-AATAAAGG-------------------------- ----------------------TAACAGAAAGCAACATTAA----ATATAA--------- -----AGCAGAG------------------------------------------------ ------------------ACAAGAGAGGAAATAAATAA---------------------- -----AATAAAAACAGAAAAA------AAT----------------GTTAACAA------ -A-------------ATCCAAAGTGTGA-T---------AATTGAT-------------- ----------------------------------------------AATG--------TA --------------ACA-ATAATTAA---------------------TATAAACA----T AAACA-----------GAA---TA------------------------AAT--------- ----------------------AAAA---------------------------------- ------CAATGAAAATAA-----------------------------ATAATATTAAGG- ---------------AAATAATT-----------------------------TTA----G CAAC--TTTATTCCATTACTTTGACAA----CTTAATTGAAAA----------------- --TAGA------AAACTAA-TTATATGCTTA---AAAAAA------------------AA GA--------------------------------GAGTTTTACCAAAA------AAAATA ACTGTTTAAATAAAA-------------------ATAAAA------GA-T-GAAAT---- -----------GA------------------------------------TTT-CAA---T AGAAAAAATA-------------------------AAAATTG---------TCCTGAAAA ACTTTC------------------------------------------------------ --------------------------------CTA-------TAGAGAAAACT------- CCA------GGCTCA--CTG---------------------------------------- G----------------------------------------------------------- ------------------------------------------TTTCACTATTGAATTCTA TATTCCATA--AAAAAAAA-AATCAA---------AAGCTC----AGAAA---------- -----------CAG---GTTTATACCGGTAAAT-ATTAGA--ATATAG---ATGAAAT-- ACAACCTTTCCT----------TGAAAAA---------TAC-----GTCCTTCAA----- -AAACCGAAGCA---AGAAAGAA--AAAAATTTGATC----------------------- ATACA------------CA-AAATTATTTTAGAAAATGAAT-T---------TGTTAT-- -GAAAACCCTTTC---------TATAAGAAC---TCCAGGTGA--AGAGAG--------- --------------------------TA-------------------TTCT--------- ----CAACTCATTT---TATAATCAAGCCAGCATA------------------------- ACTATA----ATATCTGAAAATAGA-------GAAGAG-GA-----------GACACTTT CCAACTCATTAG-----ATAAGG---------------TA------ATAC---------- ----------------------------------------A--TAAAA-------CAGTT ------------------------GACAAAATAAAAAAAAAAAAAAAAAATTAC------ -------------A-GACCAATAT---CTT----TTATGAATATAGAT------------ ------------GCAAAAATCC-TTA--------------------A----TAAAATATT AGC-AAATCACAATCATAAGAATAGGATAA--CC--------------CA--ACACCAGA GCACCAAGATACATA---------AAATGGATATTAGA--TCAAAAG------------G GAGAGATAGGTATTCCAAAGTAGCTTTCTCCGATGAATTGCAAGGCTGGTGCAAAATTGG -T----------------------TT-AAC-----ATTCAAAATAATCAATCAA------ ---ATTCACAGTAT------TAATTT----AATAAACAACAAGAT----AATATCA---A TACACATAAATA---GATGC---AGAAAA-GCATTTGACAA---AATTCAACACAAATT- ---------------TATGA---------T---A--AA-----AACTCACCAT---AAAA TAAGAATTAAAGGAACAT-----ACTTCAATTTGATAAA--------------------- ------AGGCATCTAT-GAAAAA--------CCTACAGC-----------TAACAT--CA TATTTAATGTTAA-----AAG-ACTGAAAGC----TTTC---CTC----CT--AAAAATT AGAACA----AGGCAAGG-ATAC--CCAGTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTCTATTC---ACCATTAT AAT---GGAAATTCTAACTAATGTAAA--------AAG-AC------AAGAA---AAAAA --AATAAAAATCATTCCAAAAGAT---AAGAAA------GAAAGCAAAAAT--------- --------ACTTTA-TT--T---ACAGA------AAATAT------AATTGTTTTTTTA- -GAAAATC--CAAAATTAATCATCACAA---------C------ATTTAAACAAA--AAA ACATAAAAATAATAAAAAAAA--TAAGTGGATTTAGCAAGG--TCT-----CAGGATAC- --AA-------------------------------AATTGA-------------AAT--- ATAAAAAT----CACA-------------------------------------------- -----TTTATATT--TA-TATATTAAC---------------AGTAAAAAAT-----TAA A------------------AAATAAAATT-ATTTTTAAATTTAAT----TTTAAAATCGC T---------------------AAAAAGATA---------AAAATTAAATAAATAGGAAT AAAAAT--------AA--C-AAAAGATATG---A---AACAACTAT---ACAA-AAAAAA CTATAAAACAA------TATTA-AAAAAAATTA-AA------------AAAA-------- ------------ATAA--AAAG--AAA---TGTA---AA--ATTTT---------TACA- --TGTTT------ATT-GATTGGAAGACTC-A---A---TATT--------------G-- TTAAAATA-----------------------------------------TCAATTGTCTT CCCCAA--ATTGATGTATA-------------------GA---TTCAATAGA---ATT-- ------T-CCATTAAAAA--T---------------------CCAATA-AG---AATTTT ------------------------------------------AAATGAAGTTG------- -------------------ATTATAAACTACA------TATAAAA--ATTTATATGGAAT G-------AAAAAGGACCAA---GA--ATATCCAAAGTGGACATCAAAA---AAAA--GA ATATCCGATC--T-------TGA--GGAATTATG-----ACTTTATAGTAAAAACAGTAA TCAAAC-------------------------AA---GATTTCAAA-AGTGAA---AAC-A TTA--------------AAATAAT----TA------------TAAAAAAAAAAGAAA--- ----ATCAAG--AA---ATTA-GAAGTGATAGAATTGTT------GG---AAATTAAT-- -TTTT----------------AAA-------TATGAAA----TTTAA---GATTTTT--- AAAAAA--AAAAGTAAGGATATCC--A-------------------GCAAA--GA---AA AG------------ATATCGCGTTTTTAACAAATGA---------------ATCCC---- ------A----ACCCCTGA-----------------------TATGT-ATAAAT---ATG ---------AGA----AACCT---GTTCTAAAA-------AACATT--ATA--G---AAA AAAA-TTAATT-ATAGATGG---AT---CATGGAC---ATAAAAGTA--AAACCAAAAAA CAT------------------------AATGTTTTTAAAA---------------GAAAA ---CATT------G------------------A-AGAATATCTTTGTGACTTTG--GGT- -----TAAGCAAAGATT-----TTTTAGATAT-AAAA------AAAACAAATCACAG--- --AAAAATA---AA-----AT---TGATCAA-TTACAT----------TATATCAAA--- AATAAAAA-----C----------------TAATA-------CA--------------TT -TAAAATTACACT-------------TATTAATATAAAAAA------------------- ------GACATTTGTTAAGCCAATGCCAGATGACAAAC--T-AGCAA---AAAACATAT- --GTAACACAGGAAT--------GT-------GAGAAAAATTCCTAACCATAATAAAGCG ACATAGGACATATAAT-AA--AATTAT------------AATTCCTAT------------ --------------------AA--AGAAC---AAC--AATATAA-TTGG---CAAAAGTC T--AGA---------AGAGGTGAAATTAAA---AGGCAGAT------------------- ----ACGTAAAAAAA--------TTTGAAA---AA-GTAACCATT--A-GCATACTAAAA AGT----------GCTCAAAAACACTGAGTTATCA------------------------- -----GGGA-AATTCAAA-----------------GT-AAAATCACA-------GT---- ----------AAACAA---------CCAT----ACAACTACAAGAATAACTGACATAA-T A--AAAAAAA-----TTAAT-------ACACTA-AATG--T------------------- ------TGGT-GAGGATGTG----------GAGCA------------------------- ------------AATAGAATTCTTAC-ATATTTCTGG--TAGG----------------- ----------AGTGT--A-------------AACT---GGTAA----AATAACTTTGA-- ------AAAATGAT---TGGGACAG-TTCTT-------AAATATAA----------ACCA -ATTT---GA--TCTAGCAATTGTA---------------------CTCCTAGG-TATT- --------------TATCACAAAATAA----ATG----AAA------------------- --------------AATATGAC--AAAACAATTTGT---------AAATG----AATGGT CATA--ACACCTTTATTCACAATGCACAAAAACAA--G---------------CAA---A T-----------ACAAAAGAGCTCAATGAATAAAG--AAAT----TAAAGG--------- -----TAATA-------------------------------------------------- ------------------------TATTTATTCATACAATGAACAAC-----CATATGAA GTTCTAG----AACAGGCAAAACTAATACATGGTGAAAAATAAAATTAGAACATTGTTTG CCTTTGGGGGGTGGGGCAG----------------------------------------- --------GGATTGACTGGGAAAGGG-C---AGGAGACAACTTTCTGGGGTGATGGTAAT GTTCTATATCTTGATAAGGGTTTGGGTTACGCAGGTGTATGCATTTGTCAAAACTCAGTG AATG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----TACA---------------------------------CTTAATATTTG-------- ---TAT---A-TTTCACT-------------GTATGTAAAT---TTATATCTAAACAAA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAAAACTATAAAACAAA---------------TAT----------- ------------------------------------------------------------ ---------------------------------------------------TGAACTCTA GTTAATGATATGCATGC------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGAAATGTTTAGGAGAAA------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTGT-------------------------------------------------A CTG-------ATGTCTGTAA-------CTAACTTTGAAATGCACCAAAACATAAGATG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TTGATGGATGGATAGAGG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------GATGAATAGAT---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GGATAGAT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ATGTGAT-AAATCAAA------------------------------------------- ------------------------TAT-----------------AGTAAA---------- -------------ATGTTAATGGTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAATCTAGG-----------TGGTGGGTAGGTATAT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GGATG TTCACTGTAA-------------------------------------------------- ------------------------------------------------------------ -----------------AATTCTTTCAACTATGGTGTGTGTGTGAAAATTTTTA--TAAT AAAATGTTGGAAAAAAA------------------------------------------- ------ >L1MC3 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AAAGAAATA-----------ATGGCTGAGAACATTTC ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -CAAAATAA--------------------------------------------------- ------------------------------------------------------------ -------------------------------ATGACAGAAA-----CCAAACC------- ----------------------------------------ACAGATCCA--------AGA AGC--------------------------------------TCAG--------------- -------AGT----GCAGCTCCTT-------------------GC-CAG---CAACAGAG CAAAGCA----GC------AATAAAA---ACAACTTTGACAAGTTAACAAAAGA------ ----------------------TCTACACTAAGGAT------AAAAATATTCCAACTG-- --AAAGACTAAAGAC--------------------------AGGACCCATTGC-----AA AGAAGCT---------------------------------------------AAAAACCT T-GAAAAAA--------------------------------------------------- -GATTAGA----------TGAATGGCTAACTAGA-------------------------- -------------------------------------------ATAACCAGTGTAGAGAA ----------GTCC---------------TTAAATG------ACC---------TGATG- GAAC----TGAAA---------ACCAT---AGCACGAGAACTACGTGACGAATGCACT-- ---AGCTTCAGTAGCCAA----------------TTTG--------------------AT C--AAGT------------------GGAAGAAAG-GGT-ATCAG--TGATTGAAGAT--- -CA------TGAAA-T-----GAAGCGAGAAG---------AGAAGTTTAGA---GAAAA AAGA---GTAAAAAGA-AA---------TGA---ACAAAGCCTCC--AAGAAATATGGG- ACTAT--------G---TGAAAAG--ACAAAATCTACGT--C-TGATTGG--TGTA---- ----------CGTGAAAGTGACATAGAAAATAAT---AATGGAATGA---------AAAA AATATTT---GA-----AAAAATTATGGCT--GAAGAATTTTCAAAAAT----------- ---------AAATAAAAAAAA--CAAA--ACTCAAATTC-----AGGAAACTCAGAGA-A CACCAAGCA------------GGATAAA-TAC--------------CAAAATATCTACAC C-------T---------------------AGGCACATCATATTCAAACT------GGG- AGGAAAAAAAA---CGAAAAACAAAAATTTTT---------------------------- -------------TAAAAGA--CGCCAGAAG---AAAAAAACT----------------- -----------TAC---CTATAGAGG-AAAAAAAA--------------TAAGAAT--TA CAGTGGACTTC-----TCATCAGAA--ACCAT--CAAAA------AAAAAAGAGAATG-- -----------TAA-AAATGTA-T-------TCAAA---TGTT-------------TAAA GAAAA---------------ATTATAA-TCA--ACAAAAAA--------TTC---TATAT CCA-----------GCAAAATTATAC-----TTCAA-AAGTAA-------AG-------- ------------------------G-AGAAATAAAGACTTTCTTAGACAAAC-AAAAACT GAGAGA-GTTTATCACCAGCAGAA---CTGCTTTAC-AAGAA------------------ --------------------ATGTTAAAAGAGGCTTTTAAAAACAAATCTATGAATTCTT ACCAGCTACTAAAAGATAATGCCAAAGCTAAAAGTAGTTCTTCAGGCAGAAAATTAATCA AGG----------------------------------------------------AAAGG AAAGTTATATAGGTCAGAAACTCAAATCTACTTAAATAATGGAAGAATGTTAAGTGTTTT CTTATTCTGAATTGATAACTGTTTGCTAAATATAATAGTAATAATTATGTGATTATAAAT TATAAATAATAGAAAAGAAAAAAAGAAAAATAATAAAAAAAAT----------------- -----GAAAATGAAAAATAGAAAATACAATTATAAAAAAACCTCACTTCCATGTGAACTA TATGAGTGTTGTTAGAGGTAGTTTTTATTGTATTTAAAGTTGTATAATATTAAAAGTAGC ACCACAATCATTTATATAACTAAAAAAATATAATTGATATGCTAAGAAA----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------AAAAATAA AATGGAATAACATAAAATGCTCAAGTAAAAGTAGAGAAGGCAGAAAAAGAGAGGAAAAAA AAAAAAGAAAAGAAAAAGTTCAAAAAATAGAAAACATTGAAAACATGGCATATATTAATC CAACTATATCAATAATCACTTCAAATGTGAATGGTCTAAATTTATCAATTAAAGGCAACA GTTATAGGTGTGAATAAAAAACAAGCCAAAAATAAAAAACAAACAGACAAAAAGGTAAAT GGTGTACAAGAAACCTAACTG--------------------------------------A TTGGTGGTTACAAACAAACTTTCATAATATAAAGATGTTGGAGAAATTGGGAATACTCTG TTATATGGTCTCTA---TACTATATTTGAAGTAGTACAGTGTTATTTGAAAGTGGGCTTA GATTATTTTATG------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TGTATATGAATATACAT TTCTATATATAATAGTATGTTTATATTATA-------------------------TATAA TAGTGTATTTTATTTTATTTTA----------------------------ATATATATTT TTGAAAGAAA-TATAATTTATATACTAATACGCACATATAAAATAAGCCCTAAAGCAGTG GCTAAGAGCATTTACAAAAGAAAAATAGGTAAATGGAATAGA------------------ ------------------------------------------------------------ --------------------------------------------------ATAGAGATGA AAGAAGTATCCAAATA-CAAAATTAAACAGTTAAAGGGCAAAAAAACAGAGAAAAAAAAC AAAAGAAACAAAAAAGAA------------------------------------------ ---------------------AAAACAATAGAGA--------------ATATTATACTTA GGAAA------------------------------------------------------- ------------------------------------------------------------ ------------GCAGAAAATCAGTTACAAAACA-------------------------- ------------------TGGTA-------AATATTAAT--------------------- ------------------------------------------------------------ --------------------ACAAATATA--TTAATAATCAC-TATAAAT-------T-T GAAT--GGTCT--AAATAC---CACAATT----------------AAAG---------AT AAAACTCTACAG----AATA---------GAC-------ATAA---AGAAAACATTCAA- ---CTAAAAATGATGT-TTTGTCTA-CAAAAAATCTATTT-TAAAA--TCAAAAATAAAA A-AAGGGTAAAAATAAAGAGA---T------------GGAGA----A-AGATATACCATG T--------------TAACAC------TAATC---------------------AAAAG-A AAGCTG--GAGT----AGCTATATTAATTTC-AGACAAAACAGATTTCAAA-AC------ ----AAAGAAAA---TTATCAGAAAA-AAAA-AAGGACAT------TAAAT------AAT GATAAA---AGGGACAATA------CAACAA---GAAG--------AC-ATAACAATTTT TAA----------------------TATATATG---------TACCAATCAACAAAATAT AAAA--ATA-CATGAGGCAAAAAATAATAGACAT--AA----AAAAAGA---------AA TAAACAAAAAC------ACAATTATAATTGGAAACTTCAATA----------------AA CCTTT------GACATT-AATTGAAAAATCAA---------------------AAAAAC- -----AAAA-------------AATCAATAAAAATATAGATGACCTGAAC-AGAACTATC AA------TCAAATTG---ATCTAAATGAAATTTATA--AA----ATACTCCATACAAAA AC---AGCAGAATACACAT------TCTTCTGAAGAT-----TC--CAT-GAAACATTCA --A----CAAAATAGAAAATATTCTAGGCCATAAAACAAA-------------------- -CATCAATAAATTTAAAAAAA--TAAAAAT----------------AATACAAA------ -ATACTTAGACA---AAACACAAAAGAA-TTAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------GA --------------AAG-ATAGCTGG---AAAATTCCCAA----ATAATTGGAAA--C-T AAAGAACAAA-TTTCTAATAAACA-AAAAATA--GAAAAAAGAAAA--AGT--C-AAAAG AGAAATT---------------AAAAAATATTTT---GAACT------------------ ------AAATGAAAATAA-AAA------------TATAAC--ATATAAAAAAATA-TGG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AA TA--------------------------------------------AA------------ ------AAAATTAAA-------------------ACAAAAATC---AA-T-AAAATAAAA AAAAG------AA------------------------------------AAA-AAA---T AAAAAAAATA-A---------AAA----AAACCA-AAAGGTT------GTTTTTTGAAAA GATCAA------------------------------------------------------ --------------------------------TAA-----AATTGATAAACCT---CTAG CTA------GGCTAA--CCA------------AGAAA------------------AAAAA A---AAGA-AAAAAC-----------------AAAAAAC--------GAAAA-----TA- ---------AAA-AATGAAA--AA----------GAGGT---CATCACTATTGATCCC-A TG-GAAATC--AAAAAGAT-AATAAA---------AGAATACA--ATAAAATTAAAACTA TGAAAAACTATTAAAAACTCTGTGCACATAA---ACTTGATAACTTAG---ATGAAAT-- GAATCAATTTCT----------TGAAAAA---------CAC-----AAACTTCCA----- -AAATTCACACA---AGAAGAAATAGATAACCTGAAT----------------------- AGGCC------------TA-TATCTATTAAAGAAATTAAAA-T---------AATAAT-- -AAATAAACTTCC------AAAAAAAAAAGC---ACCCGGACC--AAATGG--------- ------------TTTTACA-GATA--AA-------------------TTTTA-------- ----CAAAAAATTT---AAGAAA-AAAATAA--TA-CCAATT----------TTCCAAAA TCTTTT----CA---AAAAAATAGAA------ACAAAA-AG-----------AATACTAA CTAAATCATTTT-----AAGAAACC-----AATAT---TAACCAT-ATAC---------- ------AAAAACACACTACAACTATCATAACACTAAAGATCAAAAGAC----ATTTAAAG AAA---------------------AAA---AATATACAAAA---AAAAAATTAT------ ---------------AAACAATAAAAAC------TAATAAAAATAGAT------------ ------------GAAAAAATTC-TCA--------------------A----CAAAATATT AAC-AAATCA------------------AA--TC--------------CA--AAA----- --------AATTATA---------AAAAAAATTATACA--TCATAAC------------C AAG---TGGGA-TT----------TATTCCA------------GG--AATGAAAGGCTGG -T----------------------TT-AAA-----ATTTAA--AAATCAATCAA--TGTA ---ATCCACTATAT------CAACAG----ACTAAAGAAGAAAAAT---CATATGA---- -TCATATCAATT---GATGC---AGAAAAA---TTTAACAA---AATTCAAAATCCATT- ---------------TATGA-------------A---------AAATCTTAGC---AAAA TAGGAATAAAAGAGAATT-----TTCTCAACTTTATAAA--------------------- ------GAAAATCTAC-AAAAAA--------CATCCAGT-----------TAATAT--CA TATTAAATGGTGA-----GAA-ACTGGATGC----TTTT---CCC----TT--AAGATTA AGAACA----AGGCAAGG-ATGT--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATTAT ACT---GGAAGTCCTAGCTAGTGCAAT--------AAG-AC------AAGAA---AAAGA --AAAAAAATGTATACAAATTGAA---AAAAAA------AAAATAAAA--C--------- ------TGTCTTTA-TT--T---ACAGA------TGACAT------GATTGTCTATGTA- -GAAAATC--CCAAAGA---ATTTACAA---------A---------------AA--AAA TTCTAAAACT---------AA--TAAGTAATTATAACAAGG--TCA-----TAGGATAC- --AA-------------------------------GGTTAA-------------TAT--- AAAAAAAT----TAAT-------------------------------------------- -----TTCTTTCA--TA-TATACAAGC---------------AATAAAAAA------TTG A------------------AATATAAATAT-------AAAACAATAAAAATTAAAATA-- ----------------------AAAAAAATA------------------------GAAAT AAAAAT--------AA--A-AAAATATATA---C---AAAATATAT---ATAT-AGAAAA CTATAAAACAA------TGATA-AAAGAAATAA-AA------------GAAA-------- ------------ATCT--AAAT--AAA---TGGA---AA--GATAT---------TCTA- --TGTTC------ATG-GATTGGAAGACTC-A---A---TATT--------------G-- TTAAGATG-----------------------------------------TCAAT--TCTT CCC-AA--CTTGATCTATA-------------------GA---TTCAATACA---ATC-- ------C-CAATCAAAAT--C---------------------CCAGCA-AG---CTATTT ------------------------------------------TTTAGATATTA------- ----------------------AAAAAATTAT------TCTAAAA---TTTTTATTGAAA A-------GAAAAAGACCTA---GA--ATAGCCAACACAATACTGA------AAAA--AA AAA---AAGT--T-------GGA--AGACTCACA---ATACCTAATTTCAAAAC-----T TATTAT-------------------------AA---AACTATAAT-AATCAA---GAT-A GTG--------------TGGTATTAA--AA------------A---AAAAATAAACA--- ---CATAAAT--AA---A----AACAAAATAGAGAGCCC------AG---AAATAGAC-- -CCAC----------------ACA-------AATATAG----TAAACT--GATTTTT--- GAAAAA----GGAAAAAAGCAATTCAA-------------------AAGAA--AA---AA GA------------ATATTTTTTT--AAAAAAATG----------------TGCTT---- ------GAAAAAAT--TGG-ATATCCA---------------TATGC-AAAAAA---ATA ---------AAAATAGAAAAA---AAACT-----------TATACC-------TTTCACA AAAA-TTAACT-CAAAATGG---AT---CATAGAC---CTAAATGTA--AAATGCAAAAC TAT------------------------AAAACTTTTAAAA---------------GAAAA ---CATA-------------------------GAAAAAAATCTATGTGACCTTG--GGT- -----TTGGTGATGAGT-----TTTTAGATAC-AACACCA---AAAACAAAAATCAT--- --TAAAAAA---AA----AAT---TGATAAA-TTGGAC----------TTTATTAAA--- ATTAAAAA------------------CTT-CTGCT-------CT--------------GT -AAAAGACACTGT-------------TAAGAGAATGAAAAG------------------- ------A-------------CAAGCC------ACAGAC--T-GGGAA---AAAATATTT- --GCAAAACACATAT--------CT-------AATAAAGGAC--------TT--ATAAA- ---AAAAATATATAAA-AAATTTTTAA---AAA------AA--ATAAA------------ ---AAT--------------AAAAAAAAA---AAA--AAAAAAAATAAA---AAAATGGG C--AAA---------AAA--TCTGA---AC---AGACAACT------------------- -----CACCAAAGAA--------GAT----------ATGGCAAAT--AAGCATATGAAAA GAT----------GCTCAACATCATTT-GTCATTA------------------------- -----GGGA-AATGCAAA-----------------TT-AAAACAACA-------AT---- ----GA---GATACCA---------CTAC----ATACCTATTAGAATGGC---------- ---AAAAA-------TGAAAAA------------AATG--C------------------- ------TGAC-AAGGATGGA----------GAGCA------------------------- ------------ACAGGAACTCTCAT-TCATTGCTGG--TGGG----------------- ----------AATGC--A-------------AAAT---AGTAC----AGCCACTTTGG-- ------AAGACAGTTTGTGACA--G-TTTCTT--ACAAAGCTAAAT--ATAGTCTTACC- -ATAT---GA--TCCAGCAATTATA---------------------CTCCTAGG-TATT- --------------TA-CCCAACTGAT----------TTGAAAACT-------------- --------------TATTTCCACAACAAAAACCTGC---------ATACA----AATGTT TATA--GCAGCTTTATTCATAA-TTACCAAAAACT--G--GA--AACA--ACCAAA---A TGTCCTTTA---ATAAGATAAGTGAATGGATAAAA--AAAA----TA------------- -----TGGTA-------------------------------------------------- ------------------------CATCC----ATACAATGGAATAT-----T--ATTCA GTGATAA----AA----------------------AGAAATGAAATATCAAAACAT---- ------------------------------------------------------------ --------AAAAAGGCATGGATAAATGCAAATGGAAAATGCCAAACTAAAGAA------- ------------------ACTATTTTGAAAAGGAGGGAAATGATGTATAATAACATATTA ACGAGTGAACACTGTTGGAATGGGGAATGTCACACACTGGGGCCTGTTGTGGGGTGGGTG GAGGGGGGAGGGATAGCCTTAGGAGATATACCTAATGTTAAATGACGAGTTACTGGGTGC AGCACACCAACATGAATGAATTATACATTTGTAACGTAACCTGCACATTGTGCACATGTA CCCTAAAATTTAAAGTATTAA--------------------ATAAACACATATTCAAGCT GTTTATAGCAGTTTTATTTATAACCTCCAAAAACTGGAACCCACCAAGATGTCTTTCAAC AGATCAATTAAGGAAGAAATTGATATATCCATGCAATGAACTGTTATTAGCAATAAAAAG AAATGGAATATCTTAC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CATGAAAGAACATGGATAAATCTTAAATGCACATTTCTTAGTGAAA-- ------------------------------------------------------------ ---------------------------------------------------TGACATTCT GGAAAAGGCAAAACTAT------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGAGACGGTAAAAAGATC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTGGTT-----------------------------------------------G CCA-------GGGGTTTGGGGGGGGGGAGGGGAGGGTTGAATAGGTGAAGCACAGGGGTT TTTTAGGGTGGTGAAACTATTCTGTATGATACTGTAATGGTGGATACATGACACTACATT TGTCAAAACCCATAGAACTTTACAGCACAAAGAGTGAACCTTAATGTATGCAAATTAAAA AAATCATTTAGGAGGTCGGGGGATCCCAGGATGGAATGCAGAATGTGACAAAACAATCTA ACTGTATTACAAATGTATGAAACAACCTCACTGAAGGGGGTGGGGGAAAAGGTGCTGACC TAAGTAACTTTGGAAATGAGTGGAGTCTGTAAGACTAAAGGCAAAAGGAACTGTACATAA GCACTGTACTCTAGTTGATAAAGTTGTTTCCCATGGGGGTATGGGTTAACAATTCTGAAA CCACTATACATGTATACTGGAATTGAACAATTAAGTAAATGGATGGCAGATGGTGGGAGC CAGGTTTCTCACTGTTGGAGTGGGAGGTTACAGATAAGCAAGGGGAGGAGGCTAGAATGA TCCATGTGGTAATGGATTAGAGTTGGAGACATCAGTATGAACTCATGTTTAGCTTAATAT AGATACAGATGGTTACATATAGAAA-------TATTTATAGATATGTGTATATACATGGG TTAGTATACACACATATATTTCCTTGCTCTGTCAGCTGAGAGGGCCTAGAAGCAATGACA CCCCAGTAGCAATGAGCACACCTAGTGCCCAGATCTTGGTTTCAATACCATTCTCCAATA AAAGGAACCAGGGCTCCTTGGAGAAATGCTGATTCTAGGACTGGGGCAGGAAATATACAA GATGAGCCTGGAGCATCTTGTAGTGCCAGAAAGTAAGGAAGTGCTCAAAAAAAAAACAAA AACAAACACAAAACCCCACAATGATGGGGGTATGTCAAAGGGACACAGGAGCCAACTGAA AGAGCTCCCAATGGCCAAAGCTGGAACAATTTGAAAATAAAGTAGTATTGGATTATAACC CAAAGTAT-AAATAAAT------------------------------------------- -----------ATCCATGAGTCCATACTGATAAATAAATGATTGAATAAATTAAATGGGG GAGAAGAGACAAATCCCATGCAGAAGAATCCAAATAATTTATGTAGATACTCCACCCTCA AGGAGGGGGTAACTCCCCACTCCTTAAGTGTGGGCTGTACATAGTGACTTCCTTCCAAAG AGTACAGTATGGGAAGGGGGGGAAAGAGTAACTTTACAGTGAGAAACCTGACAAACACTA CCTCAGCCAGTGATCAAGGTCAACATCAACAGTGATAAGTCATGTTGATAGTATGTACCC TTGATATGATGTGATGAAAATGGCACTTTACCTCTGTGGTCTTCCTCCAAAACCCATAAC CCCAGTCTAATCATGAGAAAAACATCAGACAAATCCCAATTGAGGGACATTCTACAAAAT ACCTGACCAGTACTCCTCAAAACTGTCAAGGTCATCAAAAACAAGGAAAGTCTGAGAAAC TGTCACAGCCAAGAGGAGCCTAAGGAGACATGACGACTAAATGTAATGTGGTATCCTGGA TGGGATCCTGGAACAAAAAGGACATTAGGTAAAAACTAAGGAAATCTGAATAAAGTAT-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GGACTTTAGTTAATAATAATGTATCAATATTGGTTC--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ATTAATTGTAACAAATGTACCACTAATGTAAGATGTTAATAATAGGGGAAAC TGGGTGTGGGGTATATGGGAACTCTGTACTATCTTTACAAATTTTCTGTAAATC--TAAA ACTGTTCTAAAATAAAAAGTTTTTTTAAAA------------------------------ ------ >L1MC1 ------------------------------------------------------------ ------------------------------------------------------------ -----TTTAGTTCCAGTTTTCTGG-----------------CTTTCAGGTAAGGAGCTTC GAAGTTACC----------------------------ACTCCATCTTAACAA-------- ----------------------------------CAAGTAAAAAGCTGAACAAACTGGAA AATCAACAACTCTTCTTAGA---TCCGTAAGAGAAGTGAGGTC----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------ACAGGGCAAACCGCTGCCCCCAAA------ATTGGAGAGAC------AGACAGG CAAATACAGGAAATCCCAGTTTCCGGAACAAGAA---------C-TCAGGAGCCAGAACC TCCTCAGGAATCAG----------TGCCGGG---------------------------GT AGG-------------------------------------AAAACCTGAACTGTAATTGA CAAATTGTTGGAGGCTCAGTGTGGAGAGGTCTGA-----GA---GTTAAAAACTCGAGG- ----------------------------------------------------AGGGGGGC CCAGTCATGGGGGGGCCCCCACAATTTTGTGAGTTTTT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CCTCCAGGAGCT----TGACCAGG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------TTCTCACAGTGAATATCGGAGAAAAA-------------TCCCCTCATGCTTCC GGC--------------------------------------------------------- ------------------------------------------AGGGAGAGGGGAAAAGGA AC-------------------CATTTTGAAATACACCAGAG------------------- ------------------------------------------------------------ ----CAT----------------------------------------------------- ------------------------------------------------------------ -------------------------------------TCTGTTCTTCTTAACAAGGCC-- ---------TGCCCTCAGGAGAAACTATTTTACCAGAGCCTAACCT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GCTGGGGTTT-------TATCAGAGCTTAACCTACCTGGG GGAAGGGAAA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TACCCAACTCCAGCCCCCTCTAGCC------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ATCCTGTCCCACCTAAGGGGG GGGGGGGGAGAAAG--------------------------------AGGAAG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GCTGAGAAGCACTTGTGAAGTTCACAGTCCAGGGGCA CAGGCTCACT-------------------------------------------------- ---------------------------------------AAAAGACT------------- --G-----------AGACCTAATCATAGGACTATAGAACACTTCCCCCCCCC-------- ----------------------------------------------CCACACCTTACC-- --------------------------------ACCAC--ATTACTAAAGGC--------- ---------CTATTTACCGCAGTTCCTTTTACCCA------------------------- -GTACATCATGTCCACCT------------------------------------------ ------------------------------------------------------------ -------------------------------TTCAAAAAAA-----TTTCAAGACATACT AC--------------------------------------AAAAAGGAA--------AAA AACA-------------------------------------CAGGTTGAAGA-------- -------GAC----AGAGC---------------------------AAG---CATCAGAA CCAGAGT-------------CAGATATGGCAGGGATGTTGGAATTATCAGACCA------ ------GGAA------------TTTAAAACAACTAT----------GATTAATATGCT-- ----------------------------------------------------------AA GGGCTTT---------------------------------------------------AA T-GGAAAAA--------------------------------------------------- ------------------------------------------------------------ -------------------------------------------GTAGACAGCATGCAAGA ----------ACAG-----------ATGGGTAAAAA------AAA---------TGCTA- GAGA----TCAAA---------AACAC---TGTAACAGAAATGAAGAATGCCTTTGAT-- ---GGGCTCATTAGTAGA----------------CTGG--------------------AC A--TAGC------------------TGAGAAAAG-AAT-CTCTG--AACTTGAGGAT--- -ATCTCAATAGAAA-CCTCCAAAACTGAAAAGAAAAGAATGAAAAGCAAAGA---GAAAA AAAACTGGTCAAAAAT-AA---------AAA---ACAGAATATCT--AAGAAATGTGCG- ACAACTGCAGAAGACGTACAAAAAACATGTAACATATGT--A-TAATGGG--AATA---- ----------CCAGAAA---GAAAAGAAAGAGAG---AAAGGAACAG---------AAGA AATATTT---GA-----AACAATAATGACTT-ATAAATTTCCCAAATTA----------- ---------AAGTCAAAACAC--AAACCAAAGAAAATCC-----AAGAAACTCAAAAA-A CACCAAGCAA-----------AATAAAT------------------GAAAA----TACAC A-------T---------------------AGACATATAATATTCAAATT------ACA- AAAAATAAAAA---ATAAAA--AAAAAATTT----------------------------- -------------TGAAAGA--AGCCAGAGAAAGAAAAAAACACCT-------------- -----------TAC---CTATAGAGG-AGCAAAGA--------------TAAGAAT--TA CATCTGACTTC-----TCCTCAGAA--ACCATG-CAAGC------AAG-AAGAGAGTG-- -----------GAG-TGAAATA-T-------TTAAAG--TGTT-------------GAGA GAAAA---------------AAAACA--CCA--ACCTAGAA--------TTC---TGTAC CCT-----------GAAAAATTATCC-----TTCAA-AAGTGA-------AG-------- ------------------------G-AGAAATAAAGACTTTCTCAGACAAAC-AAAAATT GAGAGA-ATTTGTTGCCAGTAGAC---CTGCCTTGC-AAGAA------------------ --------------------ATGTTAAAAGA----------------------------- -----------------------------------AATTT------------TTTTAGAA GAA----------------------------------------------------AAAAA AAGGAAAATGATATAGGTCAGAAACT---------------------------------- -------------------------------CAGATCTACATAAAGAAAGGA-------- ------------------------------------AGAGCAT----------------- ----CAGAGAAGGAATAAGTGAAGGTAAAATAAAAACT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------TTTTTTTTTCTTTTTTTTAATTGATTAACAGATAACAGTTTGTT CAAAATAATA-------------------------------------------------- ---ATAGCAACAATGTATTTGATTATGTATGCTTATGTATATATGTATATATATATATAT ACATATGTATGTTTATGTATAAGTGAAATGAATGACAGCAATGATACAAGGGACAGGAGG AAGGAATTAGATTA---------------------------------------------- ----------------------------------------------------TTTTGTTA TTATAAGGTACTCG---CACTACCCGTGAAGTGGTATAGTGTTATTTGAA---------- --------AGTG------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- -------------------CTTGGATTAGT-------------------------TGTAA ATGTATATTGCAAACTCTAGG-----------------------------GCAACCACTA AAAAAAGTTA-AAAAAAAGAAGTATA---------------------------------- ---------------------ACTGATATGCT---------------------------- ------------------------------------------------------------ --------------------------------------------------AAGAAAGGAG AGAAAATGGAATCATA-TAAAATGCTCAATTAAAACCACAAAAGGCAGAAAAAGAGTGGA AGACAAAAATAGGAA--------------------------------------------- ---------------------CAAAGAACAAGGG--------------CA---ACAAATA GAAAA------------------------------------------------------- ------------------------------------------------------------ -------------CAGTAACAAAT------------------------------------ ------------------TGGTA-------GATATTAAT--------------------- ------------------------------------------------------------ --------------------CCAACTATA--TCAATAATCAC-TTTGAAT-------G-T CAAT--GGTCT--AAATAC---ACCAATT----------------AAAAGAC------AC AGATTGTGTCAG----AGTG---------TAT-------AAAA---AAAAAAAAAACAAA TAAATG-------TAT-TTTATATA-AAAAAAACACACTT-TAAAT--ATAAAGACACAT A-TAAATTAAAAGTAAAAGGA---A------------TGAAA----A-AAATATACCATG C--------------TAACAC------AAATC---------------------AAAAG-A AAGCAG--AAGT----AGCTATATTAATTTC-AGACAGAGCAGACTTCAGA-GC------ ----AAGGAAAG---TTATCAGGGAT-AAAG-AGGGGCAT------TACAT------AAT GATAAA---GGGGTCAATT------CTACAA---GAAG--------AC-ATAACAA-TCT TTA-----------------A----TGTGTATG---------TACCTAACAACAGAGCAT CAAA--ATA-TATGAGGCAAAAACTGATAGAACT--AC----AAGGAGA---------AA TAGATGAATCC------ACTATTATAGTTGGAGACTTCAACA----------------CC CCTCT------ATCAGA-AATGGACAGATCCA---------------------GCAGGC- -----AGAA-------------AATCAGTAAGGACATAGTTGAACTCAAC-AACACCATC AA------TCAACTGG---ATATAATTGACATCTATA--GA----CTACTTCATCCAACA AC---AGCAGAATACACAT------TCTTCTCAAGCT-----CA--CAT-GGAACATTCA --C----CAAGATAGACCACATTCTGGGCCATAAAACACA-------------------- -CCTTAACAAATTTAAAAAAA--TAGAAAT----------------CATACAAT------ -GTCTGCTCTCA---GACCACAATGGAA-TTAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------GA --------------AAG-ATAGCTGG---AAAATCCCAAA----ATACTTGGAGA--T-T AAAAAACACA-CTTCTAAA---TA-ACATATG--GGTCAAAAAAAA--AAT--C-TCAAG AGAAATT---------------AAAAAATATTTT---GAACT------------------ ------AAATGAAAATGA-AAA------------CACAAC--TTATCAAAATTTG-TGG- GA-----TGCAGTAAAAGCAGTG-----------------------------CTTAGAGG GAAA--TTTATAGCATTG----AATGC----ATATATTAGAAAAG---AAGAAAGATCT- --AAAATCAAT-AATCTAA-GCTTCCACCTT---AGGAAAC--TAGAAAAAG------AA GA-----GCAAATTAAAT-------------CCAAAGT--AAGCAGAA-GAAAAGAAAAA ATA---AAAATTAGA-------------------GCAGAAATC---AA-T-GAAATTGAA AACAG------AA------------------------------------AAT-CAA---T AGAGAAAATC-A---------ATA----AAACCA-AAAGCTG------GTTTTTTGAAAA GATCAA------------------------------------------------------ --------------------------------TAA-----AATTGATAAGCCT---CTAG CCA------GGCTAA--GAA------------AGAAA------------------AAAAG A---GAGA-AGACAC-----------------AAATTAC--------TAATA-----TC- ---------AGA-AATGAAA--GA----------GGGGA---CATCACTACAGATCCC-A TG-GACATT--AAAAGGAT-AATAAA---------GGAATACT--ATGAA---------- -----------CAA---CTCTATGCCCACAA---ATTTGATAACCTAG---ATGAAAT-- GGACCAATTCCT----------TGAAAGA---------CAC-----AATCTGCCA----- -AAACTCACACA---AGAAGAAATAGACAATCTGAAT----------------------- AGGCC------------TA-TATCTATTAAAGAAATTGAAT-C---------AATAAT-- -TAATAACCTTCC------AAAACAGAAAGC---ACCAGGCCC--AGATGG--------- ------------GTTCACT-GGTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAGGAA-GAAATTA--TA-CCAATT----------CTCTACAA TCTCTT----TC---AGAAGATAGAA------GCAGAG-GG-----------AATACTTC CTAACTCATTCT-----ATGAGGCC-----AGCAT---TACCCTA-ATAC---------- ----------------------------------------C--AAAAC-------CAGAC AAA---------------------GAC---ATTACAAGAAA---AGAAAACTAC------ -------------A----AAATAT---CTC----TCATTAACATAGAT------------ ------------TCAAAAATTCTTCA--------------------A----CAAAATATT AGC-AAATTA------------------AA--TC--------------CA--ACA----- ------ATGTATATA---------AAAAAAATTATACA--CCACGAC------------C AAG---TGGGA-TT----------TATTCCA------------GG--TATGCAAGGCTGG -T----------------------TC-AAC-----ATTTAA--AAATCAATTAA--TGTA ---ATCCATCACAT------CAACAG----GCTAAAGAAGAAAAAT---CACATGA---- -TCATATCAATA---GATGC---AGAAAAAGCATTTGACAA---AATCCAACACCCATT- ---------------CATGA---------T---A--AA-----AACTCTCAGT---AAAC TAGGAATAGAGGGGAACT-----TCCTCAACTTGATAAA--------------------- ------GAATATCTAC-AAAAAA--------CCTACAGC-----------TAACAT--CA TACTTAATGGTGA-----GAA-ACTAGAAGC----TTTC---CCA----CT--AAGATCA GGAACA----AGGCAAGG-ATGT--CCCCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTTTTC---AACATCAT ACT---GGAAGTCCTAGCTAATGCAAT--------AAG-AC------AAGAA---AAGGA --AATAAAAGGTATACAGATTGGG---AAGGAA------GAAATAAAA--C--------- ------TGTCTTTG-TT--T---ACAGA------TGACAT------GATTATCTATGTA- -GAAAATC--TAAAAGA---ATCAACAA---------A---------------AA--AAC TCCTGGAACT---------AA--TAAGCAATTATAGCAAGG--TTG-----CAGGATAC- --AA-------------------------------GGTTAA-------------TAT--- ACAAAAGT----CAAT-------------------------------------------- -----CACTTTCC--TA-TATACCAGC---------------AATGAACAAG-----TGG A------------------ATTTGAAATT-AAA----AACACAATACCATTTACATTAGC ACCC------------------CCAAAAATG---------AAA------TACTTAGGTAT AAATCT--------AA--C-AAAATATGTA---C---AAGATCTAT---ATGA-GGAAAA CTACAAAACTC------TGATG-AAAGAAATCA-AA------------GAAG-------- ------------AACT--AAAT--AAA---TGGA---GA--GATAT---------TCCA- --TGTTC------ATG-GATAGGAAGACTC-A---A---TATT--------------G-- TCAAGATG-----------------------------------------TCAGT--TCTT CCC-AA--CTTGATCTATA-------------------GA---TTCAATGCA---ATC-- ------C-CAATCAAAAT--C---------------------CCAGCA-AG---TTATTT ------------------------------------------TGTGGATATTA------- ----------------------ACAAACTGAT------TCTAAAG---TTTATATGGAGA G-------GCAAAAGACCCA---GA--ATAGCCAACACAATATTGAAGG---AGAA--GA ACA---AAGT--T-------GGA--GGACTGACA---CTACCTGACTTCAAGAC-----T TACTAT-------------------------AA---AGCTACAGT-AATCAA---GAC-A GTG--------------TGGTATTGG--CA------------A---AAAAATAGACA--- ---AATAGAT--CA---ATGG-AACAGAATAGAGAGCCC------AG---AAATAGAC-- -CCAC----------------ATA-------AATATAG----TCAACT--GATCTTT--- GACAAA--GGAGCAAAGGCAATAC--A-------------------ATGGA--GA---AA AG------------ATAGTCTTTT--TAATAAATGG-------------------A---- ------G-AACAAA--TAA-AGATATA---------------CACACAAAAAAAAAAATG ---------AATCTAGACACA---GACCT-----------TACACC-------CTTCACA AAAA-TTAACT-CAAAATGG---AT---CATAGAC---CTAAATGTA--AAATGCAAAAC TAT------------------------AAAACTCCTAGAA---------------GATAA ---CATA------G------------------G-AGAAAATCTAGATGACCTTG--GGT- -----TTGGCAATGACT-----TTTTAGATAC-AACACCA---AAGGCACAATCCAT--- --GAAAGAA---AG----AAT---TGATAAG-CTGGAC----------TTCATTAAA--- ATTAAAAA------------------TTT-CTGCT-------CT--------------GC -AAAAGACAATGT-------------CAAGAGAATGAAAAG------------------- ------A-------------CAAACC------CCAAAA--T-GGGAG---AAAATATTT- --GCAAAAGACATAT--------CT-------GATAAAGGAC--------TG--TTATC- ---CAAAATATACAAA-GA--ACTCTT---AAA------AC--TCAAC------------ ---AAT--------------AAGAAAACA---AAC--AACCTAA-TTAA---AAAATGGG C--CAA---------AGA--CCTTA---AC---AGACACCT------------------- -----CACCAAAGAA--------GATATAC---AG-ATGGCAAAT--AAGCATATGAAAA GAT----------GCTCCACATCATAT-GTCATCA------------------------- -----GGGA-AATGCAAA-----------------TT-AAAACAACA-------AT---- ----GA---GATACCA---------CTAC----ACACCTATTAGAATGGCCAAAAT---C C--AGAAC-------ACTGACA-----ACACCA-AATGCTG------------------- ------TGGT-GAGGATGTG----------GACAA------------------------- -------------AAAGAACTTTCAA-TCATTGCTGG--TTGG----------------- ----------AATGC--A-------------AAAT---GGTAC----AGCCACTTTGG-- ------AAGACAGTT--TGGCA--G-TTTCTT--ACAAAACTAAAC--ATACTCTTATCA TATAT---GA--TCCAGCAATCATG---------------------CTCCTTGG-TATT- --------------TA-CCCAAATGAA----TTG----AAA---ATT------------- --------------TATGTCCAC-ACAAAAACCTGC---------ACATA----GATGTT TATA--GCAGCTTTATTCATAA-TTGCCAAAACTT--G--GA--AGCA--ACCAAG---A TGTCCTTCA---GTAGGTG-----AATGGATAAAT--AAAC----TG------------- -----TGGTA-------------------------------------------------- ------------------------CATCC----AGACAATGGAATAT-----T--ATTCA GCGCTAA----AA----------------------AGAAATGAGCTATCAAGCCAT---- ------------------------------------------------------------ --------GAAAAGACATGGAGGAAA-C---TTAAATGCATATTACTAAGTGA------- ------------------------------------------------AAGAAGCCAATC TGAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAGG---------------------------------CTACATAC-TG-------- ---TAT---GATTCCAACTAT-----------AATGACATTCT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GGAAA-------AGGCAAA---------------ACT--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GAGACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TAA--------AAAGATC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTGGTT-----------------------------------------------G CCG-------GGGGTTGGGG-------GGGAGGGAGGGATGAATAGGCAGAGCACAGA-- -------------------------------------------------GG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ATTTTAGGG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CAGTGAAACT------------------------------- ---------------ACTCTGTATGATACTATAATGGTGGATACATG------------- ------------------------------------------------------------ ------------------------------------------------------------ -TCATTAT-ACATTTGT------------------------------------------- -----------------------------------------CCAAACCCATAGAATGTAC AACACCAAGAGTGAACCCTAATGTAAACTA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TGGCTTTGGGTGATAATGATGTGTCAATGTAGGTTC--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------ATCAATT GTACAAATGTACCACTCTGGTGGGGGATGTTGATAGTGGGGGAGGCTGTGCATGTGTGGG GG---------------------------------------------------------- --CAGGGGGTATATGGGAAATCTCTGTACCTTCCGCTCAATTTTGCTGTGAACC--AAAA CTGCTCTAAAAAAAAAAGTTTTTT------------------------------------ ------ >L1MC2 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGGGAAACTGAGGTACC CGACTTCTG------------------------------CTCACACTAGA---------- ------------------------------------------------------------ -----------------CTTCCTGCTTCACCTAAGAGAAGAAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------TACCTGA----GAAGCACTTGTGA------AGGTCACAGCC-------AGAAG- ---GGCACAGCCACCCTGAATGACAGAGCTCTAA---------T-CATAGGATTACAGAG CA---------------------------------------------------------- ----------------------------------------------------------CT TTCCACTGCCCACACCTTCCCACCACATCAG----------------------------- ----------------------------------------------------CGGGGCTC CTGAATAATAACAAGGCTTTACAGAACTGCAAGCCTCAGACACTACTTAAGA-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------AGGAGCCTCTAAGAAAACCC----AGAGATAA--CA GAGGAGA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------CAAAACCAAGGATATTAGAAGAAATT-------------TCTAGAGGAAATTCT AAACT------------------------------------------------------- -----------------------------------------ATAACAAATAAAAATAAAG AT-------------------AACAATAAAAACAACAAAAT------------------- ------------------------------------------------------------ ----CATAAAAA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GATAAACATA-- ---------AAATCTAACATTAAAGGAATATTTATCATCTAATACTTTG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TATAGCGTTT-------TCTAAAAAAATTAAAAAAGCGTC AAAAAGAGAAAGAAGAGTTTGAATAATC-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------AAAGTAATATCAGA ATCG------GAATTCAAAACAGTCATG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTTTTTAAAATGTAGGGGACG TCAAAATAAATAGA--------------------------------AACATTCTAACATT AA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AAAAGCACA-----------CCGGATAAAAGAAAA-- ------------------------------------------------------------ --------------------------AGGACGTATGGAGAACCTAGC------------- --A-----------AAAAATCAATACCAAAAAGCAACAAAAGGAT--------------- ----------------------------------------------ATGCAAGACATCAA AAACACTGTAACAGGAATGTAACATGCCTTTGATAGA--ATCATCAGTAGA--------- ---------CTGGACAGGAACTA------------------------------------- -GAAAAGAATCAATGAGCTTGTGGTCATGTGAATGGGAACTTTCCAAACTGAGA------ ------------------------------------------------------------ -------------------------------TGCAAAGAGA------------------- ----------------------------------------AAAAAATGT--------AAA AACA----AAGGATTA-------------CAAT--ATT---CTAG---AACT-------- -------ATC----GGAGATTTTAAATGTGTAAATCGAATGCCAC-CATAAAGAGTAGAA GAAA-------------------------AAGAAATTGAGTAATGAGCAGAAAGGATAGT AATAATATGAAATACTTCCAGTATTAAATTACTGATTACAAAATCGTATCAAAGAACCAG GAATACTAATAGGCAATCCACTATC----------------AAAATATAAAAT-----AA CGAAACT----------------------------AAAATAATGAATACAAGAATGACAA C-AAGAAAA--------------------------------------GAACTACCCCCTC TAGATACA-----------GAGTTAAACACTAAA-------------------------- -------------------------------------------TTCAAAATTTCAAAAGG ----------CAAGCAAACTATAATAATGTTAGAAG------GAAGGGAGGTTGTACAA- GAGA----TCAAA---------AACAC---TGTAACAAAAATGAAGAATGCCTTTGAT-- ---GGGCTCATCAGTAGA----------------CTGG--------------------AC A--TGAC------------------TAAGAAAAG-AAT-CAATG--AGCTAAAGGAT--- -ATATCAACAGAAA-T-----CTCCAAAGTGG---------AAAGCAAAAAA---GAAAA AAAA---AT---TAAA-AG---------TGA---AGAAAATATAA--TAGAACTATGGA- AGAAC--------T---ACAAAAG--GTATAACATATGTATAATGAATGG---------- ------------ACAAAACGGAAAGGAAAAAGAA---AAAGGAACAG---------GAAA AATATTT---GA-----AATAATAATGGCT--GAAAATTTTCTAAAATT----------- ---------AATGACAGACACCAAACC--ACACAGATCC-----AGGAAACATAGAGA-A CACAAAATA------------AAAATAAATAA--------------CAAAAAAAATACAC C-------T---------------------AAGCACATCATATTCAAACT------GCA- GAAAATAAAAG---ACA-----AAAAAATCT----------------------------- -------------TGAAAGA--AGTCAGAGG---AAATAAACACAT-------------- -----------AAC---CTATAGAGG-AACAAAGA--------------TAAAAAT--TA CATCAAACTTT--------TCAGAA--ACCATG-CAAAC----------AAGAAGATG-- -----------GAG-TGAAATA-T-------TTAAAG--TGTT-------------GAAA GAAAA---------------AAAAAT--CCA--ACCTAGAA--------TTC---TGTAT CCA-----------GTAAAATTATCC-----TTCAA-AAGTGA-------AA-------- ------------------------G-AGAAACAAAAACTTTCTCACAAAAAT-ATAAATT AAAGGA-AATTGGTGGAAGTACAT---GGATCTTGC-AAGAA------------------ ----------TTATTTAGTTCTTCAGAGAGA----------------------------- -----------------------------------AGGGAAATGATATAGGTCACAAACT CAG--------------------------------------------ATCTACATAAAGA AAGGA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------AAAACAT----------------- ---TGGGGAAGGAAAAAATGAAAGGTAAAAACAAAATA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------TTTTCTTTTTATATTCTTAATTGATCTAACAGATAAGTTTTTTCA AAGTAATAAT-------------------------------------------------- ---------------------AGTAACAATGTATTGGGTAATTATAGTTTATGGAT---- --------------------AAGTGAAATAAATGACAGCAATGTTATAAGAAAAGGGGGA AAGAATTAGGAATA---------------------------------------------- --------------------------------------------------------CTCT GTTATAAGGTACTT---GCATTACCCATAAGTAGTATAGTGTTATTTTAA---------- --------AGTG------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- -------------------CTTAGATTAGT-------------------------TGTAA ATGTATATT-----------------------------------------GCAAACTCTA GGGCAACCAC-TAAAAAATTTTTTAAAAAAAA---------------------------- ---------------------ATTGAAATGCT---------------------------- ------------------------------------------------------------ --------------------------------------------------AAGAGAAGAG AGAAAATGGAATCATA-TAAAATGCTCAATTAAAACCAGAGAAGGCAGAAAAAGAGTGGA AGGCAAAATAAAAAAAAGAAA--------------------------------------- ---------------------CAAAGAACAAGGG--------------CA---ATGAATA GAAAA------------------------------------------------------- ------------------------------------------------------------ -------------CAG----------TTACACATATGGTAAATTATTAATCCAACTATAT TAATAATCACTTTAAATATGGTA-------GATATTAAT--------------------- ------------------------------------------------------------ --------------------CCAAATATA--TCAATAATCAC-TTTAAAT-------G-T GAAC--AGTCT--AAATAC---ACCAATT----------------AAAATAC------AG AGAC--TGTCAGA---AGTA---------GATTTT----AAAA---AAACTAGACCCAA- ---CTGTACACTGTAT-ATAGGTTA-TAAGAAATCCACTT-TAAAT--ATAAAGACAGAG ATACAGTTAAAAGTTAAGGGAATAT------------GGAAA----A-AGATATATCATA C--------------TAACGC------TAATC---------------------AAAAGAA AAGCCG--AAGT----AGCTATATTAATTTCAAGATAAAGCAGACTTCAGA-GC------ ----AAGGAAAA---TTATCAGGAATAAAAG-AGGGGCAT------TACAT------AAT GATAAA---AGGATCAATT------CTCCAA---GAAG--------AC-ATAACAA-TCC TTA-----------------A----TGTGTATA---------TGCCTAATAACAGAGCAT CAAA--ATA-CATGAGGCAAAAACTGATAAAACT--AC----AAGGAGA---------AA TAGATGAATCT------ACTATTATAATTGGATATTTCAATA----------------CT CCTGT------TTCAGT-AATTGACAGATCCA---------------------GCAGGC- -----AGAA-------------AATTGGTAAGGATGTAGTTGAACTGAAC-CGCTTAATG AA------TCAACAGG---ATCTAATTGACATTTATG--GA----ATATATCATCCAACA ACAAAAGCAGAATACACAT------TTTTCTCAAGTT-----CA--CAT-GGAACATTCA --T----TAAGATAGACCACATTCTGGGCAATAAAAGAAA-------------------- -GCTTAACAAATTCAAAAGAA--TAGAAAT----------------CATACAAA------ -ATATGTGCTTAGAGGACCACAATTGAA-TTAAATTAGAAATCACT-------------- ----------------------------------------------AATACATACCAAAT ATTTACAGATAGCTGGA-ATCTTAGA---AAAATTCTAAA----CATAATGGAGA--T-T AAACAACACA-CTTCTAAAATCAA-ACATATG--ACTCAAAGAAGA--ATC----TCAAG AAAAATT---------------AAAAACTATTTT---GGGCT------------------ ------AAATGAAAATGA-AAA------------TACAAT--ATATCAAAATTTC-TGG- TA-----TGCAGCAAAAACAGTG-----------------------------CTTAAAGA GAAA--TTTATAGCATTG----AATGC----ATATATTAGAAAAG---AAGAAAAACCTC TGAAAATAAAT-AATCTAA-GCTTCCACATTAGGAAAAAAC--TAGAAAAAG------AA GA-----TCAAATTAAAT-------------CCAAAGT--AAGCAGAA-GAAAAGAATTA AT----AAATTTAGA-------------------GCAGAAAAA---AA-TGAAAATGCAG AAATC------AA------------------------------------CAG-------- ---AAAAATC-A---------AAA----AAACCAAAAACTGGTTCTTGGTTTTTTAAAAC GATCAA------------------------------------------------------ --------------------------------TAA-----AATTGATAAATCT---CTAG CCAGGTTTTGGCTAA--CCA------------AGAAA------------------AAAAG AGAGGAGA-AGACAC-----------------AAATTAC--------TAATA-----TC- ---------AGA-AATGAAA--GA----------GGGAC---CATCACTACTGATCCC-A TG-GACATT--AAAAGGAT-AATAAATAAAAAAAAGGAAAATT--ATGAA---------- -----------AACTCTCTCTACCTCAAATT---ATTTAATAACTTAGATAAGGAAAT-- GGCCCAATTCCT----------TGAAAGAACTATCTACCAC-----AATCTACCAAACTC TAAACTCACACC---AGGAGAAATAGATAATCTGAAT----------------------- AGGCCTATATACATATATA-TATCTATTAAAGAAATTGAAT-C---------AATAAT-- -TAATAACCTTCC------AAAACAAAAAGC---ACCAAGCCC--AGATGG--------- ------------ATTCACT-GACA--AA-------------------TTCTA-------- ----CCAAATATTT---AAGGAA-GAAATTA--TA-CCAATT----------CTATATAA TCTCTT----CC---AAAAAATAGTA------AAGAGAAGAATTTCTAATGTAACACTTT CTAACTCATTCT-----ATGAGGCC-----AGCAT---TACCCTA-ATAC---------- ----------------------------------------CAAAAAAA-------CAGAC AAA---------------------GAC---ATTACAAGAAA----GAAAACTAT------ -------ACAGACA-GACCAATAT---CTC----TCATGAATATAGAT------------ ----------ACGCAAAAATCC-TCA--------------------ACAAAAAAAATATT AGC-AAATCA------------------AA--TC--------------CA--AGA----- --------ATATAA----------GAAAGAATTATACA--CCATGAC------------C AAG---TGGGA-TT----------TATTCCA------------GG--TATGCAAGGCTGG -T----------------------TC-AAC-----ATTTGA--AAATCAATTAA--TATA ATCAATCACTACCCTGTAATCAACAG----GCTAAAGAAGAAAAAT---CACATGA---- -TCAT--CAATATAGAATGC---GGAAAAACCATTAGCCAA---AACCAACCACCCATT- ---------------CATAT---------TA--A--AA-----AATTCCCAGT-ACAAAC TAGGAATAGAGGAAAACT-----TCCTCAACTTGATAAAGAAGGAAACTCCCTCAACGTG ATAAAGAATTATCTA--AAAAAA--------CCTACAGC-----------TAACAT--TC ATCTTAATTGTGA-----GAA-ACTAGATGC----TTTC---CCA----CT--AAGAATA GGAACA----AGACAAGG-ATGT--CCCATCACCCCTCTCACCACTCCTCGCGACCTCAT CACCTCCCAAAGGCCCCACCTCTTAATACTATTGCACTGGGGATTAAGTTTTCAACAGTA TGAATTTTGGAGGGACACACGCATTCAGACTATAGCACCACTCCTATTC---AACATCCT ACTGAAGGAAGTCCTAGCTAATGCAAT--------AAG-AC------AAGAA---AAGAA --AATAAAAAGTATACAGATTGAG---AAGGAA------CAAATAAAA--C--------- ------TATCTTTG-TTCTTTTCACAGA------TGACAGAT----GACATTTTATGTA- -AAAAATCCACCAAAGA---ATCAACAG---------A---------------AA--GAC TCCTGGAACTAATACCTGCAA--TAAGTGATTATAGAAAGG--TTG-----CAGGATAC- --AA-------------------------------GGTTAA-------------TAT--- ACAAAAGT----CATT-------------------------------------------- ------TCTTTCC--TATTATACCAGC---------------AATGAACAAC-----TGG A------------------ATTTGAAATT-AAA----AATGTAACACCATTTACATTAAC ACCACCC---------------CCAAAAATG---------GAA------AAACTAAGTAT TAATTTTAAATATAAA--CAAAAATATGTA---T---TAGATCTAT---ATAA-GGAAAA CTATAAAACTC------TGATG-AAAGAAATCA-AA------------GAAG-------- ------------ATCT--AAAT--AAA---TGGA---GA--GATAT---------TCCA- --TGTTCACGGATATA-GATAGGAAGACTC-A---A---TATT--------------G-- TCAAGATG-----------------------------------------TCAGT--TCTT CCC-AA--CTTGATCTATA-------------------GA---TTCAATGCA---ATT-- ------C-CAATTAAAAT--C---------------------CCAGCA-AG---TTATTT ------------------------------------------TGTGGATATGA------- ----------------------ACAAACTGAT------TCTAAAG---TTTATATTAAAA GGCTATATGCAAAAGACCCA---GA--ATAGCCAACACAATACTGAAGA---AGAA--AA ACA---AAGT--T-------GGA--AGACTGACA---CTACTCAAATTCAAGACATATTA TACTAT-------------------------AA---AGCTACAGT-AATCAA---GAC-A GTG--------------TGGTTTTGCGATA----------------AAAGAATAATA--- ----ATAAAT--CA---ATGG-AACTGAATAGAGAGCCC------AG---AAATAGAC-- -CCAC----------------ACA-------AATATAG----CCAACT--GATCTTT--- GACAAAAAGGAAGCAAAGACAATT-CA-------------------ATGAAAAAA---AA GGATAAATTTCTTTATAGTCTTTT--CAACAAATGG---------------TGTTG---- ------G-AACAAC--TGG-ACATCCAATGCCCCTCCTCCTACATGCAAAAAAA---ATC A--------AATCTAAACACA---TACCT-----------TACACTATTTC------ACA AAAA-TTAACTACAAAATGG---AT---CACAGAC---CTAAATGTA--AAATGCAAAAC TATAAACTGTAATAAAAATAAAAAAAAAAAACTCCTAGAA---------------GATAA ---CATAAAAGAGG------------------A-AAAAAATCTAGGTGACCTTG--GGT- -----TTGGCGATGAGT-----TTTTAGATAG-AACACCA---AAAGCACTATCCAC--- --GAAAAAA---AA----AATAAACAATAAG-TTGGAAATT-------ATTATTAAA--- ATTAAAAA------------------CTT-CTGCT-------CT--------------GT -GAAAGACACTGT-------------TAAGAGAATGAAAAA------------------- ------G------------CCAAGCC-----AAGAGAC--T-GAGAG---AAAATATTTG TCGCAAAACACATAT--------CTGATAAAGGATAAAGGAC--------TG--TTATC- ---CAAAATATACAAA-GAACTCTTGA---AAATACAAAAATTCCGAGATCACATCACTG CAAAAC------ACAACAATAAGAAAATAAAAAAT--GACATAT-TTAA---AAAATGGG C--AAA---------AGA--TCTGA---AC---AGACATCT------------------- -----CACCAAAGAA--------GTTATAT---AG-ATGGCAAAT--AAGCATATGAAAA GAT----------ACTCAACATCATAT-GTCATTA------------------------- -----GGGA-ATTGCAAA-----------------TT-AAAACAACA-------ATAGGA GATGGA---GATACAACTACACACTACTATTACATACCTATTAGAATGGCTAAAAT---C C--AAAGC-------ACTGACA-----ACACCA-AATG--C------------------- ------CGGC-GAGGATGTG----------GAACA------------------------- ------------ACAGGAATTCTCAT-TATTTGTGGG--TGG------------------ ----------AATGC--A-------------AAAT---GGTAT----ACCCACTTTGGAA CTTTGGAAGACAGTT--TGGCA--G-TTTCTT--ACAAAGCAAAAC--ATACTCTTACCA AATAC---GA--TCCAGCAATCATG---------------------CTCCTTGG-TATT- --------------TA-CCCAAATGAG----TTG----AAA---ACT------------- --------------TATGTCCAC-ACAAAAACATGC---------AAATA----AATGTT TATA--GCAGCTTTATTCATAA-TTGCCAAAACGT--G--GA--AGCACAACCAAG---A TGTCCTTCA---ATAGGTG-----AATGGATAAATTGAAAC----TG------------- -----TC----------------------------------------------------- ---------------------------------ATACAATGGAATAT-----T--ATTCA GTGATAA----AA----------------------AGAAATGAGCTGTCAAGCCAT---- ------------------------------------------------------------ --------GAAAGACAATGGAATAAC-C---TTAAATGCATATTACTAAGTGA------- ------------------------------------------------AAGAAGCCAATC TGAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAGGCTACATA--------------------------CTACATAC-TG-------- ---TAT---GATTCCAACTAT------------ATGACATT---CT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GGAAA-------AGGCAAA---------------ACT--------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------GAGACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TAA--------AAAGATC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTGGTT-----------------------------------------------G CCA-------GGGGTTTGGG-------GGGGGGGAGGGATGAATAGGTGGAGCACAGG-- -------------------------------------------------GG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ATTTTTAGGGCA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GTGAAACT--------------------------------- ---------------ATTCTGTATGATACTGTAATGGTGGATACATG------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACATTAT-GCATTTGT------------------------------------------- --------------------------------------------CAAAAC---------- ------------CCATAGAACTGTACAACACAAAGAGTGAACCCTAATGTAAACTAT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GGACTTTAGTTAATAATAATGTATCAATATTGGTTC--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------ATCAATTG TAACAAATGTACCACACTAATGCAAGATGTTAATAATAGGGGAAATTGTGTGGGGGGGGG GGGGAGGGGGGGGATGGAAGAAGGAGGGGAAATAATAATTAGGGGAAATAATAATTAGGG AAGATGGTATATCTGGGCACTCTCTGTACTTTCTGCTCAATTTTTCTGTAAACC--TAAA ACTGCTCTAAAAAATAAAGTTTATTT---------------------------------- ------ >L1ME5 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AAAAA-----------AAAAACAACAG------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -AAAAACTG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GAAACACGA--------AAA AACA----AAGCACCT-------------CAAC--ACCC--CAAA---A-AA-------- -------AAC----ACACCACCTC-------------------AA-CAG---CAACGGAA CAAAACT----GG------ACGCAAA---AAGAAATCCACAAGCTAACAAAAAA------ ------AGAA------------TTCAGAAGATCAAA-TAACAAGCAAATAAGGGAGGC-- --AACACAAAAAAAA--------------------------AAAAAACAAGGC-----AA AAAAATC----------------------------------------------------- --CAAAAAA--------------------------------------------------- -AGATAGA----------AGAAGGGAAGGGAGAAATAACC-------------------- -------------------------------------AAAAAAATAAATACAATTAAAGA ----------AAAA---------------ACAATAA------AAGAGA------TGAAG- GAAACAC-TGGAA---------ACAAA---GACACGAGAAATACAAAAAGAACGCAAA-- ---AGCCTCAGCAACCGA----------------AGCG--------------------AA A--AACT------------------AAAAGAAAG-AAA-ATCAG--AAATGGAAGAC--- -AAAATCAATGAAA-T-----AAACCAAGAAA---------GAAAAAACAAA---GAAAA AAGA---ATAAAAAAA-AA---------CGA---ACAAAGCCTCC--AAGAAATATGGG- ACTAC--------G---TGAAAAA--ACCAAACCTAAGA--A-TAATTGG--TGTA---- ----------CCTGAAAGTGAAGAAGAGAATGCA---AAAAACTTAG---------AAAA CACACTG---GA-----GAAAATAATCAAA--GAAAACTTCCCCAACCT----------- ---------AGCAAGACACCC--AAAC--AACCAAACTC-----AAGAAACACAAAGA-A CACCACAAA------------AATACAC-CGC--------------AAAAAGAGCAACTC C-------A---------------------AGACACATAATCATCAGATT------AAC- CAAAGTTAAAA---CAAAGG--AAAAAATCT----------------------------- -------------TAAAAGC--AGCCAGACA---GAAACACCAGGC-------------- -----------AAC---CCACAAAGG-AAAACCCA--------------TCAGACC--AA CACCAGATCTC-----TCAGCAGAA--ACCCTA-CAAGC------CAG-AAGAGAGTG-- -----------GGG-CCCAATA-T-------TCAACA--TCCT-------------TAAA GAAAA-------------A-ACAAATTATCA--ACCAAGAA--------TTT---CATAT CCA-----------GCAAAACTAAGC-----ATCAT-AAATGA-------AG-------- ------------------------G-AAAAATAAAATACTTCACAGACAAAC-AAATGCT GAGAAA-AGTTACCACCACCAAGC---CACCACTAA-AAGAA------------------ --------------------CTCCTAAAAGA----------------------------- -----------------------------------AGCGC--------------TAAACA TGG----------------------------------------------------AAACA AACAAA-------------ACCGGTA---------------------------------- -------------------------------ACAGCCGCTGCA----------------- ------------------------------------AAATCATGC---------CAAAAA TGAAAGAAAAAAAAATTAAGGAAAAAATAAAAGAACTA---------------------- ------------------TGTTAATCATGAATAAAATAATTTTATCTGGTAAAATTATGT TGTTTCTAAGAAATATTTTAAAAAAAAA--------------AAAATTT----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAATATTTTTATCACATTAGAGTGAGGAACCAAAGGGAAATAAATGTG TGCTAGTGTA-------------------------------------------------- ---------CTTGTCTTTTTTAAAGAGTCAATGTGTATGCAGATACGGTTTAAAATATCA ATAGTGGTAAACAAATTTATAGAATACAGCTTAATTTACAATGTTAGGGTAAATTAGAAT GTTTAAATTTTAAGCCAAGAGAAGAAATCTAGCCAATGGAAAGCAGTAACGAGGGAAAAA AGGAGTAAAAAAAGTAAATGAAAAAACATAAAACAGGGAAAAGAAACGTGTCCTAACGTA TATAGTGCTAAACG---TATATATTTAAAAGTAACTGATTCAAAGAATC----------- --------TATA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GAGGAAATAC TTAATATGAAAGATCACGAACTGGTTGAACATTTT--------------------AAAAA TGGGAAATTATAT--------------------------ATGTTCAAATCAAAAAAACTT GAGTAATAAT-CCCAATTACTGACAAAATAAAATTTAAGCCAAATATATTGTGAACCCCT AAGAAGGAATTACATACTTGTAAAAGGAAAAA---------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAATCAAG AATATATATCATCAAA-AAGCTATCTACTCCTAAATTTAGATCCCCAAAAGGAGCAAAAT ATATAATAGAGATGAAAAAAAATAAATAAATAATGAAATCATCAAATTTACCTGGAGATT GTTACCATTTTCATCTAAATAAAAATAATATATC--------------AA---ACATATA AGTAATCAGTGGAGATATTGAAGATTTGAATAATACAGTTTGATTTTTACATATGTATAG AACTCTTCCCAGTAAATACTAAAAATTTTATAAAAAAAATAGACCAAAGTTTAGGCCATA AAACAAGCCTTAATGAAGTTCAAGTGATCAATATCAATATCGTGTTCTCTGATTACAATG CAACAAAACCAAAATTAGTGACAAAATATTGGTTTAAATATATGATATTTCAGGAAAAGG CCAAAACATATGCCAGAATAATCCTTTGATAAAAAATGAAATAAAAAGGAGTAAAGAAAC ATTTGATGAATGCAATGGTATCTCACATC--TCAATACTAAC-ATTGAAT-------G-T AAAT--GGCCT--AAATGC---TCCACTC----------------AAAAGAT------AC AGAA--CCGCAG----AATG---------GAT-------AAGA---GTTCACCAACCAA- ---CCA-------TCT-GCTGTCTT-CAGGGGACTCACCT-AACAC--ATAAGGACTCAC A-TAAACTTAAAGTAAAGTGG---T------------GGAAA----A-AGATATTTCATG C--------------AAATGG------AGAAC---------------------CAAAA-A GAGCAG--GGGTACC-AGCTATATAAATATG-AGACAAAATATGCTTTAAG-AC------ ----AATAACTG---TGAAAATGAGC-CACA-AAGGTCAT------TATAT------AAT GATAAA---ATGCATGATT------TTTCAG---GAGA--------AT-ATAACAA-TTG TAA-----------------A----TATATATG---------CATCTGACATAGGAGCAC CTAA--ATTAAATAAACAAAACATAAATAGATCTCTAA----GGAGAAA---------GA TAGACTGTAAA------AAAGAGATAATAGGGAAGTTCAATA----------------CT TTACT------TTCAGC-AATAAACAGATCAC---------------------CAAGAC- -----AGAA-------------AATCAGTAAGGAAATGTCAGCCTTAAAC-TACATTTTA GA------AAAAATGG---ACCTAATAGACATATACA--GA----ACATTCTATACAAAA GC---AATAGAGTACACAT------TCATCTCAAGTA-----TA--CAT-GGAATATTCT --T----GAGGGTAGGTCATATGTTAGGCCCTAAAATAAG-------------------- -CCTTAATAAACTTTAAAAAA--TTCAAAT----------------CATATCAA------ -GTCTCTTATCT---GACCAAAATGGCA-TAAAACTAGAAACCAAT-------------- ----------------------------------------------TATA--------AG --------------GGA-TACCTGAA---AATTCACACAA----ATACATGGAAA--T-T AAACAACATG-CTCCTAAA---TA-AGCAACG--GGTCAATAAGAATGAAT--TAAAAAA GAAAATC---------------AATAAATATTTT---GAACC------------------ ------GAATGACAATGA-AAA------------CACAAC--ATATCAAAACTTA-TGG- GA-----TACAGCAAAGACAGTA-----------------------------CTAAAAGG AAAA--TTTATAGCAATA----AATGC----CTACATCAAAAAAA---TTGGAAGGTAT- --CAAATAGAC-ATAACAA-TGTTATACACC---AAAGATC--TAGAAAAAG-----AAA GATTGATACATACCAAGC-------------ACAAAGT--CAGAAGAA-AAGAGGAAATA AACAAGAAGATAAGA-------------------GCAGAATTAATAAA-T-GAAATAGAG ACTAA------AA------------------------------------GTA-AAA---T AAGAAAGGTT-A---------ACC----AAAACA-AAGGTTGAAGGTTATTCTTTGAAAA GATAAA------------------------------------------------------ --------------------------------TAA-----AGTTGATAAAACT---TTAT ATA------GGCTAA--CCA------------AGAAA------------------AGAAT A---AGAAATAAAAT-----------------TAATAAA--------AAGAA-----TA- ---------AGA-AAAAAGAATAA----------GGAGA---TATAACAGCAGATACT-A CT-GAAATA--CAAAAGAT-CATAAA---------AGACTACT--ATGAG---------- -----------CAA---TTATACACCAACAA---ATTAGAAAATCTGG---AGGAAAT-- AGACTATTTCCT----------AAAAAAT---------TAC-----AACATACCA----- -AAATCAAATCA---AGAAGAAATAGAGAATATGAAT----------------------- AGACC------------AA-TAATAAGTAAGGGGATTGAAA-TGGCTAAATGGGTAAT-- -AAAAAATCTACC------ATCAAAGAAAAG---CCCAAGACA--AGAGAG--------- ------------ATACAAA-GCAGAAAACCACTCCAGAATTGGATGGTTCTACAACGTGA GTTCCCAAACATTT---AAGGAA-GAATTAA--TG-CCAATC----------CTATACAC ACTCTT----CCACAAGAAAATAGAA------GAGGAA-GA-----------AATACTTC CAAACTCATTTT-----ATAAGGCC-----AGCAT---TACCCTA-ATAC---------- ----------------------------------------C--AAATCCAAAATTCAAAA AAG---------------------GAC---ATTTTAATAAA---ATAAAATTAC------ -------------A-CACCAATCT---TCC----TGTTGAAGATAGAG------------ ------------GTGAAAATTC-TCA--------------------A----CAAAATACT AGC-AAACTA------------------A---TC--------------CA--ACA----- --------ACATATT---------AAAAGGATCATTCA--CTATGAT------------C AAG---TAGGATTT-----AGGGGTATTCTA------------AG--GATGTAAGGACGG -T----------------------TC-AAC-----ATATGC--AAATCTATAAA--TGTG ---ATATATCACAT------TAACAG----AATGAAAGAGAAAACC---CACATGA---- -TCATCTTAGTA---AATGC---AGAAAAAGCATTTGACAA---AATCTAACAAACTTT- ---------------TATGA---------T---A--AA-----AATACTGAAC---AAAT TAGGTGTAGAAGAAATGT-----ATCTGAACATAATAAA--------------------- ------GGCTATATAT-GACAAA--------CTCACAGC-----------TAGCAT--CA TACTCAATGGTAG-----AAAAGTTGAACAC----TTCT---CCT----CT--AAGTTCA GAAATA----AAACTAGA-ATAA--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TTGCCACTTCTATTG---AATACAGA ACT---GGAAGCTCTAGGCAGAGCAAT--------TTG-GC------AAGAG---AAAGA --GAAAAGAAGCA-ACAAAGTGGA---AAGGAA------AAAGCAACA--CAAGTGAAAG CAGGAATTTCCCTG-TT--T---GCAAA------TAACAG------GATATGACATTTTC TTAAAACC--CTAAATA---CTCCACCA---------AAAGAA----------AA--GAC TGCTAAAACT---------GATTTAAGTAAAACAGTCTAAT--TAG-----TGAGATGCA TAAA-------------------------------ATCCAA-------------TTTAGG ACAAAAAG----CAGT-------------------------------------------- -----AGCCCTTC--TG-TACACTAAC---------------AATGAACTAACCCCCCCA A------------------AAAACAAATC-AAG----AAAACAATCCCATTTACAATACC TCC-------------------AAAAAAGTA---------AAA------TATTTAAAAAT AAATTT--------AAACC-AAAAGAGATG---A---AATATCTGC---ACAC-TGAAAA CTATAAAACAT------TCATG-AAAAAAATTG-AA------------GAAG-------- ----------ACAAAC--AAAC--AAA---TGGA---AA--GATAT---------TCCA- --TGTTC------ATG-AATTGAAAGAAAT-A---A---TATT--------------GTT AAAAAATG-----------------------------------------TGCAT--ACTA CCC-AA--AGCTATCTACA-------------------GA---TTCAATCCA---ATC-- ------C-CTACCAAAAT--T---------------------CCAATG-AT---GTTTTA ------------------------------------------CACAGCAATAG------- ----------------------ACAGAACAAT------CCTAAAA---TTTGTGCGAAGC C-------ACAAAAGACTCT---GA--ATAACCAAAGCACAATGGAGCT---GAAATTTA ATA---AAGC--T-------GAA--GGCATCACA---CTATGTGACTTCAAAAT-----A TATTAC-------------------------AA---ACCTATAGC-AATCAA---AAC-A GCA--------------TGCTTCTGG--CA------------T---AAAAACAGACA--- ---TATAAAT--CA---ATGG-AACAGGATGGAAATCCC------AG---AAATGAAT-- -GAAC----------------ACA-------TTTTCTC----TCAATT--GATTTTC--- AACAAA--AGTGCCAAGAACATGC--A-------------------GTGGA--TA---AA GG------------ACATATCTTT---AATAACTAA---------------TTATG---- ------G-ACAAAC--TAGAATATCCA---------------CATGC-CAAAAA---ATG ---------AAATTAGACCCC---TACTT-----------CATGCC--ATA--T---ATA AAAA-TCATCC-CAAAATTG---AT---TAAAAAC---------ATA--AGATCTGAAAC TAT------------------------GAAATTACTAGAA---------------GAAAA ---CATA------G------------------G-AGGAAAGCTCTATGAAATT------- -----TGGGCAATAATTTTTAATTTTGGAAAT-GAACCCA---ATAGTACAGGCAACACA AGAAAAAAA---AA----AAT---ACACAAG-TGGGAT----------TACATC-AA--- ACTAAAAA-----T------------GT--CTACA-------CA--------------AG -AAATAAAAC-----------------AGCAGAATGAAGAG------------------- ------A-------------CAACCT------ACGGAA--T-GGTAA-AGAAAATATTT- --CCAAACCATACAT--------CT-------GATAAGGGTT--------TA--ATATT- ---CAAAATATGTAAG-AA--ACTCAA---ACA------AATCTCAAT------------ ---AGA------AC------AA--AAACA---AAT--AACTCAA-TTTA---AAAATAGG C--AAG---------AGA----AGATGTAG---GGACAGAT------------------- -----CTCTCAAGCATACTACTGGATCTAC---AA-GGGGC-------AACATGTAATAC TTA----------GTCCAATATTATTT--------------------------------- -----------ATATAAA-----------------TT-AAAAATATATATATACAC---- ----AT---AAAACAA---------TTCT----ACATTTTATAG--------GGATACCT A--AAAAT--------------------------------T------------------- ------TGAGTGTAGATCTT----------AAAT-------------------------- ---------------------------GCAT--------TAGA----------------- ----------AATGTTGA-----------------------------CATCATTGTGTG- ------GGGAGAAGA--TGGGG--A-----TT--AGTGGATTAGAA--ATGAAAAAA--- --------AA-------------------------------------------G-TAAA- --------------TA-----------------------AA------------------- ------------------------------------------------------TAAGTA AAAT------------------------AAGAGGT-----AA--------AACTAA---A TTTAAAACA-GAATCCATG-----AACCAATAATG--ATAC----TG------------- -----TGCCA-------------------------------------------------- ------------------------TAA----------------------------ACTCA GGCATTA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AATAC----------- -----------ACTCAGTTAT----------ATG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CAC----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TTGAAAT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------CT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AAAAAA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >L1MD3 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -GAACTT----------------------------------------------------- -----AAGA--------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------TCATAAGAAA ----------TAAA---------------TTAATGG------AAA---------TGCTG- GAAA----TAAAA---------GACAC---ATTTAGAGAAATGCAAAACACATTGAAA-- ---AGTATCAAAAATAGA----------------ATCG--------------------AA C--AAGC------------------AGAAAAAAA-AGC-TTCAG--AGCTCAAAGAC--- -AAAGCCTTTGAAT-T-----AACCCAATCCA---------ACAAAGACAAA---GAAAA AAGA---ATTTT-AAA-AA---------TGA---ACAAAGCCTCC--AAGAAATGTGGG- ATTAT--------G--TTAAATAG--ACCAAACCTAAGA--G-TAATTGG--TGTT---- ----------CTTGAGG---AAGAAGAGCAATCT---AAAAGTATG----------CAAA CTTATTTGA-AA-----GGTAATAATCGAGTAAAAAACTTCCCTGGTCT----------- ---------TGCTAGAGATCTAAAGAC--ATCCAAATAT-----AAGAAACTCAAAGA-A CACCTGAGA------------AATTCAT-CAC--------------AAAAACATAATAAC C-------T---------------------AACCACAAAGTCAGCAGATA------ATCT TTAAGTCAAAA---CGAAGG--AAAACATCT----------------------------- -------------TAGGAGC--TGTGAATCA---AAAGCATCGGGT-------------- -----------ATC---CTATAAAAG-AAAACCTA--------------TCAGATT--AA CAGCAGATTTC-----TCAGCAGAA--ACCATG-CAAGT------CAG-GAAGCATTG-- -----------GAA-CA----------------------TTAT----------------- ----------------------------CCA--GCCAAGAA--------TTC---TGTAT CCA-----------GCAAAACTAAGC-----TTCAT-AAATGA-------AG-------- ------------------------G-AGAGATAAAGCCTTTTTCAGACAAAC-AACTGCT GAGAGA-ATTCACAACTACCAAGC---CAACACTAC-AAGAA------------------ --------------------CTGCTAAAAGG----------------------------- -----------------------------------AGTCC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T AAAT----------------------ATT----------------GAAAAGC-------- ------------------------------------------------------------ ---CTG-------TTT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AG------------------------C-AGAATAAGCATTCTTT----TC------ ----AA------------------------------------------------------ ------------------------------------------------------------ --------------------G----TGCACATG--------------------------- ----------------------------------------------------------AA TAG--------------------------------------------------------- ------------------AATAGA-------------------------------AGAC- -----AGAA-------------AAACAATAGAGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------ATCGACCATATCCTGGGTCATAAACAAAG-------------------- -TAAAAACAAATTTAAAAGAA--CTGAAAT----------------CATACAAA------ -GTCGGTTCTTT---GAACAT----------AAACTAAAAATCAAT-------------- ----------------------------------------------AAAC--------AG ------------------ATAACAGG---AAAATCTCCAA----ACACTTGGAAA--A-T TGATAAAACA-CTTCTAAA---TA-ATTCATG--GCTTCTAGGAAG--ACTGAC-AAAGA AAAAA-----------------ACAAAATACTTT---GAACT------------------ ------GAATGAAAATAA-AA---------------------ATATCAAAACGTA-TGG- AA-----TGCAGCTAAACCAGTG-----------------------------CTTAGAGA CAAA--TTTTCAATATCA----GACGG----CTTT------------------------- -------------------------------------------TAAA-----------AA GA-----GCAAAATAAAT--------------GAAAGC--AAGCAGAAGGAAAAAAGGGG CGA---AAAATCAAT-------------------G--AAAATA---AG-G-GATATCACT ATAGA------------------------------------------------------- -TGGAAAATC-A---------ACG----AAACCT-ACAACTA------GTTCTTTGAG-- ---CAA------------------------------------------------------ --------------------------------TAA-----AATTGATAAACCTCTCCTAG CGA------GATTGA--CAA---------------------------------------- -----------------------------------------------TC--------TT- ---------AGG-AATGAAA--GA----------GA------TACCACTACGGACCCT-- -----CATT--AAAAGGAT-AATAAG---------AAAATACT--ATGAA---------- -----------CAA---TTCAATGCATAGAA---ATTTGACAACTTAG---ATGAAAT-- GGACAAATTCCT----------TGAAAAC---------CAA-----GAACTACCA----- -AAACTTAAGC---------TAATAGATAACCTGAAT----------------------- AGCTC--------------TTATTTGTTTAAAAAATTGAAT-T---------CTTGTT-- -TAAAAAATTTGT------GACAAAGAAATC---TCCAGGCCCCTAAATGG--------- -------------TTCACT-GGTG--AA-------------------GTCTA-------- ----CCAAACATTT---AAAGAA-GAAATAA--TA-CCAATT----------CTACAACA TCTCCT----CC---AGAAAATAGAA------GAACAG-GG-----------AACACTTC CCAACTCATTTT-----ATGAGGCC-----AGCAGAATTACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGAC AAA---------------------GAAA--GTAAAAGGAAA---AGAGAACTACCTCAGA AACACGCGTGCAAACAAACCATAT---TCC----ACATGATCATAGAT------------ ------------ACAAAAATTC-TCA--------------------A----TAAAATATT AGC-AAATCA------------------AA--TC--------------TA--TCA----- --------AGATATG---------AATAA---CATACA--AATTTAC------------A AAG---TGGGG-TT----------TATTGTG------------GG--ATTGCAAGGCTGG -T----------------------TC-AAT-----ATTAGA--AAATCAATCAA--TGTA ---ATCCACCATAT------TAATAGTCTAAAGAAAAAAAAAAAAA---CAAACGACGAA TTGATATCTATA---GATGC-ACAGAAAAAA-ATTTTCCAA---AATTTAACTTCCATT- ---------------CATGA---------T---A--AA-----AATTCTCTGC---AAAC TAGGAATAGAAGGGAACT-----TCCTCAACCTGATAAA--------------------- ------GGCCATCTAA-AGAATA--------CCTACAGCAAACCTATATTTAATAC--AG TGCTTAATGGTGA-----AAG-ACTGAATGC----TTTCGAATCC----CT--AAGATCG GGAACA----AAACAAGG-ATGT--CCGCTT----------------------------- ------------------------------------------------------------ ----------------------------------TCAACACTTCTATTCTAACACATTGT ACT---AGAAATTCCATCCACTAGAAT--------AAAAGC------AACA----AGAGA --AGTATGATATATCGAAACAAAT---AAAAAA------CAAGAAAAA------------ ------CATGATTA-TC--T---ACGTA------GAAAATCCCAAGGAAATTACATT--- -GAAAATC--CAAAGGA---ATCTACAA---------A---------------AA--ATC TCCTAGAAAT---------AA--TAAGTGAATTTA-CAAGG--TTG-----CAGGATAC- --AA-------------------------------GATCAA-------------CAT--- ACAAAAAT----CAAT-------------------------------------------- -----TACATTTC--TA-TATACTAAAGC-------------AACGTGCAAT-----CGG A------------------AACCGAAATTTAAAAATTAAAAAAATTAAATTTACAATAGT TCCC------------------AAAAATATG---------AAA------TACTTAGGTAT AAATCT--------AA--C-AAAAGATGTC---C---AGGTTCTAT---ATGC-CGAAAA CTGCGATTACC------TGATGTTAAGAAATCA-AA------------GAAG-------- ------------ACCT--AAA---AAA---TTGA-------GAGAT---------ACCG- --TGTTC------ATG-AATCAGAAGAGTC-A---A------C--------------GAG TAAAGATG-----------------------------------------TCGAT--TCTC CCC-AA--TTTGATCAATA-------------------GA---TTTAATGCA---ATT-- ------C-CAATCAAAAT--C---------------------CCAGCAGGA---TTTTTT ------------------------------------------TGTGGATATAG------- ----------------------ACAAGCTGAT------TCTAAAG---TTTATATGGAAA G-------GCAAAGGAACAT---TAGAATAGCCAAAATAATTTTGAAAA---AGCA--GA ATA---AACT--T-------GGA--GGAATCACAGTGCTACCTGATTTTAAGAC-----T TACTAT-------------------------AA---AGCTACAAT-AATCAA---GAC-A GTG--------------TGGTATTGG--CG------------A---AGGGATAGACAATT ATCAATAGAT--CA---ATGG-AACAGAATAGAGAGTCC------AG---AAATAGAC-- -CCAC----------------ACA-------AATATAG----GCAAAT--GATTTTT--- GACAAA--GGTGCAAAAACAATTC--A-------------------ATGGAATAAAGGAA GG------------ATAGCCTTTTTACAGCAAATGG---------------TGTTG---- ------G-AACAAT--TGG-ACATCCA---------------TATGC-AAAAAATGATTG ACCT-----AAACCTCACTCC----ACCTAAATTTTATAGCTTACC--ATA--T---AAA AATA-TTAACT-CAAAATGA---AT---CATAGAT---CTCAAAGTA--AAATATAAAAC TAT------------------------AAAACTTTTAAAA---------------GAAAA ---CATA------GGAACTTTTAGAAAAAAATG-GGAAAATCTTCATGATCTGG--GAAT -----TAGGCAAAAAGT-----TCTTAGACAT-GACACCA---AAAATATAATCCAT--- --CAAAAAA---ATGAAAAAT---TGATAAA-TTGGAC----------TTCATC-AA--- ATTATAAA-----C------------TTCGTTGCT-------CT--------------CC -------CACTGT-------------TAAGAAAATGAAAAG------------------- ------A-------------CACACT------GCATGC--T-GGGAG---AAGATATTT- --GCAAAGCACATAT--------CT-------GATAAGGGAT--------TA--GTATC- ---AAGAATAAATAAA-GA--ACTCTC---AAA------AC--TGAAT------------ ---AAT------AA------GA--AAACA---GAT-CAACCTAA-ATTA---AAAATGGG C--AAA---------AGAACTTTGA---AA---AAACATTT------------------- -----CACCAAAGAA--------GATATAC---AG-AAGGCAAAT--AAGCACATGAAAA GACGTCG------ATTCAACATCA-TA-GTTATGA------------------------- -----GGGA-AATGCAAA-----------------TT-AAAACCACA-------AT---- ----GA---GATA-CA---------CTGC----ACATCCTCTAGAATGGCTAATTT---T T--AAAAG-------TCTGACA-----ATACTA-AGTG--C------------------- ------TGAT-GAGCATGCG----------GAGCA------------------------- ------------ACTGAAACTCGCAT-ACATTGCTGG--TAGA----------------- ----------AATGCAAA-------------CAATGTAGATAT----AGCCACTCTGG-- ------AAAACAATT--CGGCA--G-TTTTTT--AAAAGATTAAACATCCACACCTACC- -AATGTATAA--CGTAGAAATTCCA---------------------CTCTTGAT-TATT- --------------TA-CCTTAATGAG----AAT----GTA---AACA----T------- --------------ATGTTCAC--ACGAAAACCTGT---------ACGTG----ATTGTT TACG--GCAGCTCTATTCGTAATACGTCCAAAACT--G--TA--AAAA--ACCCAA--AT TGTCCTTCATTCACGGGTG-----AATGGATAAAC--AAAC----TGAGTGAGACAGCCA TACAATGGTA-------------------------------------------------- ------------------------TATCC----GTACAATGGAACAA-----T--ACTCA GCAATAA----AA----------------------AAGAATGAAGTACTGATACAT---- ------------------------------------------------------------ --------GCTAGAACATGGATGAAC-C---TCAAAATAATTACGTTGAGTGA------- ------------------------------------------------AAGAAGCCAGGT A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------A-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >L1ME1 ------------------------------------------------------------ ------------------------------------------------------------ --------------TTTAAAAAAA-----------------AAAAATAAAGAAAAAATTT TACATTTAAGATAAAAAAATAAGGCTTGATATTTACCATCCTTCATGAAACA-------- ---------------------------------------------AATTATAAAAATTTC TAAAAATATATAATTTTAAGTAAGTTAGAATAGAGTCAATCAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------ATTTGTTAAAATA----------- ---------------------------------------------GAAAGATAGAAAACA GATTATGTGACCCC---------------------------------------------- ---------------------------------------------------AGTGATTGC CCCTCTTTACTGTCTGAATATAGGAAACAGATCACTTTGAA---AAAAGAACCGAGAAAG CAGC------------------------------------------------GATAAGCT TTCTTAAGATGAGAGGAAGAAGAATGGATTGTTGAATAAGGATGGTGGCTTT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ATTTGGCGGGCCATTTTCAGGATAT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AGGTTAACATAGAGGAAGCACGGCGAACTGCG-------------GTTTGCTTGTGTCTA GGAGCCAGTACTGGTGAGT----------------------------------------- ------TCATGCAGG------------CAAAGGAACTATTCTTATAGAGGAGAATGAAAA GG-------------------TAGGAGGAAAACCAGAAAAG------------------- ------------------------------------------------------------ ----ATCTGCAGGGGA-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------TGAGGTGGCA-- ---------CCCTCTGAGTGTTTGGCTGAATGCTA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TTCCAAGAAT-------TCAAGAGAGGGACCTTCGTGAGG TTATGGTAAAAAGTGCTGAAAAACAGTT-------------------------------- ------------------------------------------------------------ ----------------------ATTTTACAAAAATTGGCAACAAAAGAGCAGAATGCAGA AAGAG-TTTTAGAAATCACTCCAACCAAGCAGACAAATCATCTTGGA------------- ------------------------------------------------------------ --------------------------------------------AATAATTAGAACCCAA CAGAGTAGGTTAAAGTTCTCCCGATGCATATGGCAACAAT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TTGTGACAA ATATGCACGGAAGG---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CATATCCA TTTATGTGAATCCAATATGTCCCAGTCACTGAAAC----TCAATTATAAAG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------CAAAATAAA-----------TTACAAGACAATGCATA CTAG-------------------------------------------------------- --------------------------ATATCGTAAATCATAGTTTAA------------- --A-----------GCAGATCGATTCATAATGAATGCAAACGTAAAAGTC---------- ------------------------------------------------------------ ---------------------------------------AGCATCAGACAT--------- ---------TAA------------------------------------------------ -AAAAATCAACGGAACTGGCTTCAAGTAGAGAAA-------------------------- ------------------------------------------------------------ -------------------------------TGTGAGAGAA-----TAAAAATATAC--- ----------------------------------------GGAATTTAA--------AGA AGCT------ACGTCA-------------TATT--------TTAAATTAAAG-------- -------GAG----GTGAAA-----------------------ACAAGGTTATAATTATT AAAAA------------------AAAGGAAAAAGTTTTCAAAATTGTAAAATTG------ ------ATAT------------TACAATATTAGAAATGAGAATTACAATATCTGAAAT-- --AAAGAATGAACCG------------GATGCGATTAATTGCAAATCATACTCTGCTGGA GATAGTA-------------------------------------------TTAGAAA--- --AGTAAAA--------------------------------------------------- -GGTCAAA----------AAAAACGCAAGAGAAACTTCC--------------------- -------------------------------------------AGAGCAAAAAGAAGAAA ----------AAAT---------TTATAGTTAAAAA------AAC---------TTCTA- GAGA----TAAAA---------CCTAC---AATATGTGAGATGAAAAATACACTGGAT-- ---GAGATTAATAACAGA----------------TTAG--------------------AC C--TTGG------------------AGAAAAAAG-AAT-AAATA--AACTTGAAGAC--- -ATAGCAATAGAAA-T-----AATCCAA-------------ACCAAAATAAA---GAAGA AAAA-----AAAAAAA-AA---------AAA---AGATAACATCA--AGGACCTGTGGG- ACAAT--------G---TCAAGCG--GTTTAATATATGT--G-TAATTGG--AGTC---- ----------CCAGAAGCAGAAGGAGAGGGAGAA---GAAG---------------AAAA AAAATTTGTAAA-----AAAAATAGCTC----AAAAATTTCCCAAATTT----------- ---------AATGAAAAACAT--AAAC--CAACAGATTC-----AAGAAGTTCACTAA-A CCCCAAACA------------GAAAAA--CAT--------------AAACAAAACCACAC C-------A---------------------AGACACATCATAATCAAATT------GCT- CAAAACCAGAG---ATAAAG--AAAAAATCT----------------------------- -------------TAAAAGC--AGCCAGAGA---AAAAAAACACAT-------------T AGTTATAAGGATACATTATATAGAAGAAATCAAAA--------------TTTTAAT--GA TAGAAAATTT------TCATTAGAAAAAAAT---GGAGC------CCA-AAAAGAATG-- -----------GAAAAACATTG---------TAAAAA--TATT-------------GAAA AAAAA--------------AAACCTTAGTCA--ACCCAGAA--------TTC---TATAC CCA-----------GTAAAAATATCC-----TTCAA-AAATGA-------AG-------- ------------------------G-TAAAATAAAGACATTTTCAGATAAAC-GAAAGCT AAGAGA-ATTCATTACCAGCAGAC---CTGCACTAA-AAGAA------------------ --------------------ATTCTAAAGGA----------------------------- -----------------------------------AGTTC--------------TTCAGA GAG----------------------------------------------------AAGGA AAAGATAAAATTGTAAAAAAGTAATAAATTCTTAACCTTCCAAGTATAAAGAAAAAGAAT AGAGTAA------------------------CAAGCCACATGAA---------------- ------------------------------------AAAAGAT--------------AGA AGGATGTTTACAAAATAACAAAGAACAAGTATCAAAAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GGAAAGTAATTACTGATTTTTTCT TATAAAGAAAACGAAGAACTTGGTTCTTTGCATACTTTTTCGAAAAGAAATATTCAAAGA AGATTTTCAGAAAGAAGGAAAATGATAGCATAGGGAAATTTTGAACTTTACAAATAAATG AAGAGCAATAGGAATGGTAAAAGTTTTGGTGTTTGAAAAAGAAAATTATATGAAAAGTTT TTTGGGCTTATATGACGTAGAGATGTAGAACATAATGAGACTAGTACAAATGACATGGGG AGGGGAATGGTAGTATATTCAATTTTGAAGGTTATTTTCTAGGTAACATTATATTAAGAA TAAAATCTGAAATGTATTAAAGAAAGAAAATAAAATAGGAAAAGAAAATCAGAAAGTAAC AATAATATTATATC---TTATTGATGAGAAGTGGTAAAATAGTAATTGAA---------- --------AGTA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------TTGTGATAAA-------------------------TTAAA GATACATATTGTAAACCCTAAA----------------------------GCAATCACGA AAACAATAAA-AAAGAGATATAGGCCAAATAATCA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ATAAAGGAAG TAAACAAGGAATCCAAAAATATACTCTTAACCACAATAAGAACAGGACGGAAAAGAAGGA AGAAAAGAAAAAAAAAAAGA---------------------------------------- ---------------------AGAGAAAAAAAGA--------------AA---ACAAATA GCAAG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------TAACA-------GATATCAAT--------------------- ------------------------------------------------------------ --------------------AAAAATATA--AAAATAATTAT-AATAAAT-------G-A AAAT--GATTT--AAACAC---TCCAATT----------------AAAAGGC------AA AATC--TACAAA----ATTG---------GAT-------AAAA---AAGCAAAAACAAA- ---ATA-------TAT-GCTCTCTA-AAAGAAACCTACTT-TAAAT--ATAAAGATACAA A-TAAGTTAAAAGTAAAAGGA---T------------GGAAA----A-AGATATACCATG C--------------AAACAC------TAATC---------------------AAAAG-A AAGCTG--GAGT----GGCTATATTAATATC-AGATAAAGTAGATTTCAAA-GC------ ----AAAGAATA---TTACTAGAGAT-AAAG-AGGGACAT------TTCAT------AAT GATAAA---AAGGTCAATT------CATCAA---GAAG--------AC-ATAACAA-TTC TAA-----------------A----TGTTTATG---------CACCTAATAACAGAGCTT CAAA--ATA-CATGAAGCAAAAAACTACAAAAAT--AA----AAAGAGA---------AA TAGACAAATCC------ACAATTATAGTTAGAGATTTCAATA----------------CT CCTCT------CTCAGT-AATTGATAGAACAA---------------------GTAGAC- -----AAAA-------------AATCAGTAAGGATATAGAAGAATTGAAC-AACACTATC AA------CCAACTTG---ACCTAATTGACATTTATA--GA----ACACTCCACCCAACA AC---AGCAGAATACACAT------TCTTTTCAAGTA-----CA--CAT-GGAACATTCA --C----CAAGATAGACCATATTCTGGGCCATAAAACAAA-------------------- -TCTCAA------------------------------------------ACAAA------ -GTATGTTCTCT---GACCATAATGGAA-TTAAAATAGAAATCAAT-------------- ----------------------------------------------AACA--------GA --------------AAG-ATATCTGG---AAAATCCCCAA----ATATTTGGAAA--T-T AAACAACACA-CTTCTAAA---TA-ACCCATA--GTTAAAAAAAAA--AAT--T-AAAAG AAAAATT---------------AAAAAATATTTT---GAACT------------------ ------GAATGAAAATAA-AAA------------CACAAC--ATATCAAAATTTG----- --------GCAGCTAAAGCAGTA-----------------------------TTTAGAGG AAAA--TTTATAGCATTA----AATGC----TTATATTAGAAAAG---AAGAAAGGTCT- --CAAATCAAT-AACCTAA-GCTTCTACCTT---AAGAAAC--TAGAAAAAA------AA GA-----ACAAATTAAAC-------------CCAAAGT--AAGCAGAA-AAAAGGAAATA ATA---AAGATAAAA-------------------GCAGAAATC---AA-T-GAAATAGAA AACAG------AA------------------------------------AAA-CAA---T AGAAAAAATA-A---------ATA----AAACAA-AAAGTTG------TTTTTTTGAAAA AATCAA------------------------------------------------------ --------------------------------TAA-----AATTGATAAACCT---CTAG CCA------GACTGA--TCA------------AAAAA------------------AAAAA AAGAGAAA-AAACAC-----------------AAATTAC--------CAATA-----TC- ---------AGG-AATGAAA--GA----------GGAGA---CATCACTACAGATTCT-A CA-GATATT--AAAAGGAT-AATAAG---------GAAATATT--ATGAA---------- -----------CAA---CTTTATGCCAATAA---ATTCAACAACTTAG---ATGAAAT-- GGACAAATTCCT----------TGAAAGA---------CAC-----AAACTACCA----- -AAGCTCACTCA---AGAAGAAATAGATAACCTGAAT----------------------- AGCCC------------TA-TAACTATTAAAGAAATTGAAT-T---------TATAGT-- -TAAAAATTTTCC------CACAAAGAAAAC---TCCAGGCCC--AGATGG--------- ------------CTTCACT-GGTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAGGAA-GAAATAA--TA-CCAATT----------CTACACAA ACTCTT----CC---AGAAAATTGAA------GAGGAG-GA-----------AATATTTC CCAACTCATTTT-----ATGAGGCC-----AGCAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGAC AAA---------------------GAA---ATTACAAA------AGAAAACTAC------ -------------A-GAACAATAT---TCC----TCATGAACATAGAA------------ ------------ACAAAAATTC-TTA--------------------A----CAAAATTTT TACAAAATTA------------------AA--TC--------------CAATACA----- --------ATATATA---------AAAAAGATAATATA--TCATGAC------------C AAG---TGGGT-TT----------TATCCCA------------GG--AATGCAAGGTTGG -T----------------------TT-AAC-----ATTTGA--AAAAAAATTAA--TGTA ---ATTCACCATAT------TAACAA----AATAAAAAAGAAAAAC---CATATGA---- -TCATCTCAATA---GATGC---AAAAAAAGCATTTGACAA---AATCCAACATCCATT- ---------------CATGA---------T---A--AA-----AACTCTCAGC---AAAC TAGGAATAGAAGGGAACT-----TCCTCAACCTGATAAA--------------------- ------GGGCATCTAC-AAAAAA--------CCTACAGC-----------TAACAT--CA TACTTAATGGTGA-----AAG-ACTGAATGC----TTTC---CCC----CT--TAAGATA GGAAAA----AAGCCAAG-AATT--TCACTC----------------------------- ------------------------------------------------------------ ----------------------------------CTAACAATTTTATTCA--ACCATTTT ATT----GAAGTTCTAACCAATGCAAT--------AAA-GC------AAGAA---AAAGA --AATAAAAGGCATACAGATTGGA---AAGGAA------GAAATAAAA--C--------- ------TGTCTTTA-TT--T---ACAGA------TGACAT------GATTGTCTATATA- -GAAAATC--CAAAGAA---ATCTATAA---------A---------------AA--AAA TACTAATACT---------AA--TAAGTGAGTTTAGCAAGG--TTG-----CAGGATAC- --AA-------------------------------GATCAA-------------TAT--- ACAAAAAT----CAAT-------------------------------------------- -----TTTATTT------TATACTATA---------------AAAAAAAAAT-----TAG A------------------------AATT--------AAAATAATAAAAATTAAAATAAC ATCA------------------AAAAATATG---------AAA------TACTTAGGGAT AAATCT--------TA--C-AAAAAATATG---C---AAAATATTTTATATAT-TAAAAA CTATAAAATAT------TGCTG-AGAGAAATTA-AA------------GAAG-------- ------------ACCT--AAAT--AAA---TGGA---GA--GATAT---------ACCA- --TGTTC------ATG-GATTAGAAGACTC-A---A---TATT--------------G-- TTAAGATG-----------------------------------------TCAAT--TCTC CCC-AA--ATTGATCTATA-------------------GA---TTCAATGCA---ATC-- ------C-CAATCAAAAT--C---------------------CCAGCA-GG---CTTTTT ------------------------------------------TGTAGAAATTG------- ----------------------ACAAGCTGAT------TCTAAAA---TTTATATGGAAA T-------GCAAAGGACCTA---GA--ATAGCCAAAACAATTTTGAAAA---AGAA--AA ACA---AAAT--T-------GGA--GGACTAACA---CTATCTGATTTCAAGAC-----T TATTAT-------------------------AA---AGCTACAGT-AATCAA---GAC-A GTG--------------TGGTATTGG--AA------------T---AAAGATAGACA--- ---AATAG----CA---ATAG-AAAATAGAAGAGAGTCC------AGAA-AAATACAC-- -ACAC----------------ATA-------TATATAA----AAAAGT---GTTTTT--- GAAAAA--------------------A--------------------------AA---AA AA------------TTAATTTTTT--CAACAAATGA---------------TGCTG---- ------G-AACAAT--TGG-AAATAAA---------------AATAAAAAAAAA---ATA AACAAAATGAATTTTAATCCA---TACCT-----------TACACC--ATA--T---ACA AAAA-TTAACT-CAAAATGG---AT---CATAGAC---CTAAATGTA--AAACCTAAAAC TAT------------------------AAAACTTCTAGAA---------------GAAAA ---CATA------G------------------G-AGAAAATCTTTGTGACCTTG--GGT- -----TAGGCAAAGAAT-----TCTTAGATAA-AACACCA---AAAACAATAATCCT--- --AAAAAAA---AA----AATTAATGATAAA-TTAAAC----------TTCATCAAA--- ATTAAAAA------------------TTT-TT----------CT--------------TT -AAAAGACACTAT-------------TAAAAAAATGAAAAG------------------- ------A-------------CAAGCC------ACAGAC--T-GGGAG---AAAATATTT- --GCAAATCATATAT--------CT-------GATAAAGGAT--------TT--ATATC- ---CAGAATATATAAA-GA--ACATAC---AAA------AA--TCAAC------------ -------------------------------------AACTCAA-TAAA---AAAAATGG C--AAA---------AAA--TTTTA---AA---AAACACTT------------------- -----CACCAAAGAA--------GATATAT---GG-ATGGCAAAT--AAGCACATGAAAA GAT----------GCTCAACATCATTA-GTCATTA------------------------- -----GGAA-AATGCAAA-----------------TT-AAAACCACA-------AT---- ----GA---GATACCA---------CTAC----ACACCTATTAGAATGACTAAAAT---A A--AAAAA-------ACTGACA-----ATACCA-AGTGTGG------------------- ------TGGT-GAAGATGTG----------GAGAA------------------------- ------------ACTGGAACTCTCAT-ACATTGCTGG--TGGG----------------- ----------AATGT--A-------------AAATG--GTTAC----ACCCCTTTTGA-- ------AAAACATTT--TGGCA--G-TTTCTT--AAAAAGTTAAAC--ATACACCTACC- -ATAT---GA--TCCAGCCATTCCA---------------------CTCCTTAG-TATT- --------------TACCCCAGAAAAA------------TTAAAACCA------------ --------------TATGTCTAT-ACAAAAACTTGT---------ACATG----AATGTT CATA--GCAGCTTTATTATAAA-CAGCCCAAAATT--GA-AAAAAAAAAAACCTAA---A TGTCCATCA---ACAGGTG-----AATGGATAAAC--AAAC----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATCC----ATACAATGGAATAC-----T--ACTCA GCAATAA----AA----------------------AGGAATGAACTACTGATACATACAA CAACATGGATGAATCTCAAAAGCATTATGCTGAGTGAAAGAAGCCAGACAAAAAAGGTGA TACATGCAGCAACAACATGGATGAAT-C---TCAAAATCATTATGCTGAGTGA------- ------------------------------------------------AAGAAGCCAGAC ACAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAGA---------------------------------GTACATAC-TG-------- ---TAT---GATTCCATTTAT------------ATGACATTCT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AGAAA-------AGGCAAACT-------------TATATATATTGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------GTGACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAA--------GCAGATC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTGGTT-----------------------------------------------G CCT-------GGGGCTGGGG--------------------GGGGGGGGGGGGAGTGAT-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TGCAAAGGGGCA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CGAGGGAACTTTTGGGGG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------TGATGGATTGGATGTG------------------------- ---------------TTCTGTATCTTGATTGTGGTGGTGGTTTCATG------------- ------------------------------------------------------------ ------------------------------------------------------------ -AGTGTAT-ATATTTGT------------------------------------------- --------------------------------------------TATATG---------- -----TCAAAATTCATCGAATTGTACACTTTAAATGGGT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAATTTTAT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------TG--TAAA TTATACCTCAATAAAGCTGTTTAATTGTTTTTAAAAA----------------------- ------ >L1MB8 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AAGGAGAAAAAAATGAAGA AAAGTGAAC--------------------------------------------------- ---------------------------------------AGAGCCTAAAAGGGACCTGTG GGACACCATCAAGCAGACCAACAGACCAACTTATACATTATGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GAATATTAGAA------------- -GGAGAAGAGAGAGAGAAAGGAGCAGAGAGATTA---------TTCAAAGAATAATAATG GCTGAAAAC--------------------------------------------------- ------------------------------------------------------------ -----TTCCCAAGTTTATTGAAAAACATTAATCT-----------ATACATCCAGGAAGC CCAGAGAACTCCAAGTAGAGATAAACAC------------------------AAAAGGAT CCACAAATTGACACATTGTAGTAAAATTATTGAAAGCCAAAGACAACGAGGAA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ATCCTGAAAGCAG----AAAGCAAAAATT AACTCATTCACATACAAGGGAACCCCAAATATCAGGTGAACAGCTGACTTCTCATCAGGA ACAATGGACTCCAGAA-------------------------------------------- -----------------------------------------------------GGTAATG GGATAATATATTTAAAGTGCTTGAAGGAAAACTCATGTCAGACAAGAATCCTATATCCAA GAAAACTATCTTT----------------------------------------------- ---------------------------------------CAAAAATGAAAGAAAAATAAA GA-------------------CATTCCCAGATAAACAAAAA------------------- ------------------------------------------------------------ ----CTGAGAGAGTTTGTTGCTAGCAGACATGACTTACAAGAAATGCTAAA--------- ------------------------------------------------------------ -------------------------------------------------GAAATTCCT-- ---------TCAGGTTGAACAAAATAAGAAGATCTGTAAAACAACTACTTAATAAAACTA ATAAAAACCGCTTTAAAAAAATGTTTAAGTATCTATAAATGGT----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------CTTAGAGGCA-------ACAAATATCTAGAAATGTTCCTT AAAAAAAAACACATGGATCATGTAATGA-------------------------------- ------------------------------------------------------------ --------------------------------ATAAATAAATAAATATGTAGTCAAGAAA ATATA-TTAAAAATCTTAAGTCTCCCAT-------------------------------- ------------------------------------------------------------ --------------------------------------------AATCAGAAACTAAAGT TAGAATATCAGGAAGAAAAACTGTACTATTGTCCCAATGCAA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ATTTGAAGGATGTCAGAGGTT TTGCAAAGGAAAAA--------------------------------AACAAACTGCAAAA CA------------GAAAACT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAATATCTATTCCCAAAGAAACTAACTTAAT----TTGTCATAGAGTGTGAATAAG TTAAAAAATAAAGGTGCTTT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AAAAAAAAATAAAGATAATGATGAAAAGCAATTGGAG AGAGATTGATGGATTCTTTGGAAATGAAGGCTGCAATGTAGGCTAGCTACTTTGCTAAAG TGAACAATAAATAAAGACAACTAGAAAGTATACTAATAACTTCAAAA------------- --C-----------ATATATCAAAAACCGACATAAAGAACTATATCTTCA---------- ----------------------------------------------AATAATCCTAAATT TGATTGAATCTGTTGATAAAGCAATCTATACACCAGGGCATTATTAAAAAA--------- ---------AAAAAAATAAGAAGCTAGCAATTAATAAAATT------------------- -GAATATGCACAAATAAAGAGAAATTCAAAGAATACCAAGTTAAAGACTAAATAAT---- ------------------------------------------------------------ -------------------------------TGAAGAAAAA-------AAAGTAAATAAA CTATAAAATTAGGAGTATTATTACTTAAGGC---------ATACTGCAACCAGGGAAAAA GACAAATCTAGTGTTG-------------AATGTGAACTATACAA--------------- -------AAC----ACAAC------------------------CCACAGAGAAAGTAAAA CAACAACCCAGGGTACAAATCACAGA---GTGGGTACTAGAATTTGAGAAAGAG------ -----------------CTTTACCTAAGGTATCCAA-AATAAAAAATAAAAGTAAGCT-- --ACATTAAATGACCCC------------------------AAAGGCTGACACGTGTACA AGGGATC----------------------------------------------------- --AAAAAAA--------------------------------------------------- -GGTAATATCTACTATATTTAATTTCTAACAAATATAGA--------------------- -------------------------------------------ATAACATTCAAAAAACA GTAAAATTTGACAC---------------TAAAAGGAAAAAAAAG------------TG- AAAA----TGAAA---------AGTAA---AAGTACAGATGCGAGAGATAACAAAAAG-- ---ATATTTAACAAATGA----------------AATG--------------------AG A--AATT------------------TGAAAAGATAAAT-CAAAAATATTTCAAAAGTTAT AGGAATAAATAAAA-C-----AACAGATTCAGAAGAAAAGTAAGACATTACAGTGAATGA AAAG---ATAAAGAAA-AAGATAGCATCTGG---AAAAAGGACCAAAAAAAAATATATGA ATAAAATAAGTAACAACAGAAAAG--AAAAAAGGTATAGAGGGGAACAAAAGCATA---- ----------TGTAAAGAGAAGGCGAAAAATGGA---AGAAAAATGATGATACATTAAGA CACATAA---AA-----AAAAATAAGGCAATAAAAAA---CCCCAATTT----------- ---------ATTGATACATAG--TA----ATTTAAATATGGAAAAAGAAAAACCAACACA AATTAACAA------------AAATCG-------------------GAAGAATTCCACGC T-------A---------------------ACATACATCCCCTTCAAGGTGTTGGAAGG- GAAAGTCAATGGGCTGAAAGA-AAGGAATCCAA--------------------------- -------------GAAAGAC--ATTGAAAGA----------------------------- -----------TAC---ATAGACAAACAAAGAGCA-------------------TTGCTA CAGTTGATAAA-----TTATGATAG--ACAATA-CAAGA------AAG-TATCTTGTGCC TCCTT----------ACCTATA---------TTAACAAACATC-------------CATA CAAAGT--------------GACTTG--TAATAGATTAAAA--------TAT---TGTAT AGA-----------GATAA------------TTCAA-ACATGA-------AATATTTTAA AATAGACAACCTAGAAAAGATGCTGTAGAAATAAAGATCAAATGTAGTAAAA-TAAAACT AAAAAA-TCATTTTGTAAGAAAACAAATTAACTTA--AGGAA------------------ ----------------------ACAAAAAGA----------------------------- -----------------------------------AA-----------------TAAAAG TAA----------------------------------------------------TAAAT AATA-------------------------------------------------------- -------------------------------AAATTTATGCTA----------------- ------------------------------------CAAACAC----------------- --------GATAAATTTATTTTTTATCT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TCTTTTTTTTTTTATTTTTATAAAATACATAAAAAAAAGAAATAAAAA AAAAAATTAT-------------------------------------------------- --------------------------------------------------------TAAG TATGGAGTTTGTAGCGTTTAAAGTTTGAATAAAAGTAAAACTACAAAAAGGGGGAAAGGA AATGGAACTATATTGGAGTAG--------------------------------------- ------------------------------------------------------------ ------CGTTTCTC---TATCTCACTGGAATTAAGTTAGTATTAATCTGA---------- --------AGTA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------ATATCATAAG--------------------------ATAA AATATGAATTGTAAGCCGTCAAGCTCCACATCAG----------------GAAATAACTA AAAAAGACAA-AT----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------TAAAATAATT AAAGTGTTAAACTAGTAAATTTAGACTTACTATAAAATAAAGGAGAAGAGAAAAAGGGGA ACAAAAAAGACATGAGACATGTAG------------------------------------ ---------------------CAAAAAAAAATTA--------------AA---AAAGGTA GATAT------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ATGACA--GAGCAGGAGTAAAT--------------------- ------------------------------------------------------------ --------------------CCAATGATA--GAAATAATCAG-ATTAAAT-------G-G GAAT--AGACT--AAACAT---GCCACTC----------------AAAAGGC------AG AGAC--TATCAT----ATTG---------GATAA-----AAAA---TAACAAGATCCAA- ---CTA-------TAT-ACTGTCTA-TAAAAGAAAAAATTTTAGAT--TCAATGATAAAA A-TAGATTGGAAGTTAAAAAA--AT------------GAAAA------AATAATTCCATC C--------------AAAAGC------TAACA---------------------ATAAG-A AAGCTG--AATG----GGCTATACTAATATC-AGACAAAATAGACTTTAAG-AT------ ----AAATAATA---TTACTAGAGAC-AAAG-AGGGACAT------TTTAT------AAT GATAAAAGTGGAATCAATC------TATCAT---GAAG--------AT-ATAACAA-TTA TAA-----------------A----TGTATACG---------AACCTAACAACAGAGCCC CAAA--ATG-TATGAAGCAAAAACTGACAGAAAT--GA----AGAGAAATGAAAACAACA TAACTAACGGA------AAAATAATAGTTGGAGACTTCAATA----------------CC CCACT------GTCAAT-AATGGATAGAACAA---------------------CTAGAC- --------A-------------GATTAACAAGGAAATAAAAGACTTAGAC-AACACTATC AA------CCAACTTG---ACCTAACAGATATCTATA--GA----AAGTTCCAACCAACA AG---AGTAGAATATACAT------TCTTTTCAAGTG-----CA--CGT-GGAACATTCT --C----CAGGATAGACCATATGCTAGGCCACAACACAAG-------------------- -TATCAATAAAATTAAAAAAA--TACAAGT----------------AATACAAA------ -ATATGTTCTCT---GACCACAATGGAA-TAAAATTAGAAATCAAT-------------- ----------------------------------------------AACA--------GA --------------AAA-AAAATTGG---AAAATTCACAA----ATATGTGGAAA--T-T AAACAACATA-CTCCTAAA---TA-ACCAATG--GGTCAAAGAAAA--AAT--C-AAAAG GAAAATA---------------AGAAAATACTTT---GAAAT------------------ ------GAATGAAAATAA-AAA------------CACAACATATATCAAAAATTATTGG- GA-----TGCAGCTAAAGCAGTG-----------------------------CTTAGAGG GAAA--TTTATAGCTGTA----AATGC----CTATATTAAGAAAG---AAGAAAGATCT- --CAAATCAAA-AACCTAA-CCTTCCACTTT---AAAACAC--TAGAAAAAC------AA GA-----GCAAAATAAAC-------------CTAAAGC--AAGCAGAA-GAAAGGAAATA ATA---AAGATTAGA-------------------GTAGAAATA---AA-T-GAAATAGAG AATAG------AA------------------------------------AAA-CAA---T AGAGAAAATC-A---------ATA----AAACCA-AAATTTG------GTTCTTTGAAAA GATCAA------------------------------------------------------ --------------------------------CAA-----AATTGACAAACTT---TTAG CTA------GATTGA--TCA------------AAAAA------------------AAAAA A---GAGAAAAAAATTACTAAAATCAAAAAGGAAAAGACTAAAATTCCAAAA-----TC- ---------AGG-AATGAAA--GA----------GGAAA---CATTACTACCAACCCTTA CA-AAAATA--AAAAGGAT-TATAAA---------GGAATACT--ATGAA---------- -----------CAA---TTGTATGCCAATAA---ATTAGATAACTTAG---ATGAAAT-- GGACAAATTCCT----------AGAAAGA---------CAC-----AAATTACTG----- -AAACTGACTCA---AGAAGAAATAGAAAATCTGAAT----------------------- AGACC------------TA-TAACAAGTAAAGAGATTGAAT-T---------AGTAAT-- -CAAAAAACTACC------CACAAAGAAAAG---CCCAGGCCC--AGATGG--------- ------------CTTCACT-GGTG--AA-------------------TTCTA-------- ----CCAAATATTT---AAAGAA----TTAA--TA-CTAATT----------CTTCACAA ACTCTT----CC---AAAAAATAGAA------GAAGAG-GA-----------AACACTTC CCAACTCATTCT-----ATGAGGCC-----AGTAT---TATCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGAC AAA---------------------GATATCACACAAAAAAA--AAAAAAACTAC------ -------------A-GACCAATAT---CCC----TTATGAATATAGAT------------ ------------GCAAAAATCC-TAA--------------------A----AAAATAACT AGC-AAACTG------------------AA--TC--------------CA--GCA----- --------ACATATA-------------AAATGATATA--TCATGAC------------C AAG---TGGGA-TT----------TATCCCA------------GG--AATGCAAGGTTGG -T----------------------TT-AAC-----ATCTGA--AAATCAATTAA--TGTA ---ATACATCATAT------CAATAG----AATAAAGAAAAAAAAT---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAAGCATTTGACAA---AATCCAACACCCTTT- ---------------CATGA---------T---A--AA-----AACACTCAAC---AAAA ATAGAATAGAAGGGAACT-----TCCTCAACCTGATAAA--------------------- ------GAGCATCTAT-GAAAAA--------TCCACAGC-----------TAACAT--CA TACTTAATGGTAA-----AAG-ACTGAATGC----TTTC---CCC----AA--AAGATCA GGAACA----AGGCAAAG-ATAT--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTCTATTC---AACATTGT ACT---GGAGGTTCTAGCCAGGGCAAT--------TAG-GC------AAGAA---AAAGA --AATAAAAGGCATCCAGATTGGA---AAGGAA------GAAGTAAAA--C--------- ------TATCTCTA-TT--T---ACAGA------TGACAT------GATCTTGTATATA- -GAAAATC--CTAAGGA---ATCCACTA---------A---------------AA--AAC TATTAGAACT---------AA--TAAATGAGTTCAGCAAGG--TTG-----CAGGATAC- --AA-------------------------------GATCAA-------------TAT--- ACAAAAAT----CAAT-------------------------------------------- -----TGTATTTC--TA-TACACTAGC---------------AATGATCAAA-----AAA A------------------AAATAAAAATTTAA----AAAACAATTCCATTGACAATAGC ATCA------------------AAAAAAATA---------AAA------TATTTGGAAAT AATTTA--------AA----AAAAAAAAGG-------AAAACATTT---AAACTTGAAAT TTCTAAAACAT------TGTTG-AAAGAAATTA-AA------------GAAG-------- ------------ATCT--AAAT--AAA---TGGA---AA--GACAT---------CCCA- --TGTTC------ATG-GATTGGAAGACTT-A---A---TATT--------------G-- TTAAGATG-----------------------------------------GCAAT--ACTC CCC-AA--ATTGATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--C---------------------CCAGCT-GA---CTTCTT ------------------------------------------TGTAGAAATTG------- ----------------------ACAAGCTGGT------CTTAAAA--TTTTATGTAGAAA T-------AAAAGAGACCCA---GA--ATAGCCAAAACAATCTTGAAA----AAAA--GA ACA---AAGT--T-------GGA--GGACTCACA---CTTCCCGATTTCAAAAC-----T TACTAC-------------------------AA---AGCTACAGT-AATCAA---GAC-A GTG--------------TGGTACTGG--CA------------T---AAGGATAGACA--- ---TATAGAT--CA---ATGG-AATAGAATTGAGAGTCC------AG---AAATAAAC-- -CCTT----------------ACA-------TTTATGG----TCAATT--GATTTTC--- GACAAG--GGTGCCAAGACCATTC--A-------------------ATGGG--GA---AA GA------------ATAGTCTTTT--CAACAAATGG---------------TTCTG---- ------G-GACAAC--TGG-ATAACCA---------------CATGC-AAAAAA---ATG ---------AAATTTGACCCC---TTCCT-----------CACACC--ATA--T---ACA AAAA-TTAACT-CAAAATGG---AT---CAAAGAC---CTAAATGTA--AGAGCTAAAAC TAT------------------------AAAACTCTTAGAA---------------GAAAA ---CATA------A------------------G-AGTAAATTTTCATGACCTTG--GAT- -----TTGGCAATGGAT-----TTTTATTAAATGAAATCA---AAAACATAAGCAAA--- --AAAAGAA---AAAA--AAT---AGATAAA-TTGGAC----------TTCATCAAA--- ATTAAAAA------------------CTT-TTGTG-------CT--------------TC -AAAGGACACCAT-------------CAAGAAAGTGAAAAG------------------- ------A-------------CAACCC------ACAGAA--T-GGGAG---AAAATATTT- --GCAAATCATATAT--------CT-------GATAAGGGAC--------TT--GTATC- ---TAGAATATATAAA-GAATTCTTAT---ACA------AC--TCAAT------------ ---AAT--------------AAAAAGACA---AAT--AACCCAATTTAA---AAAGTGGG C--AAA---------GGA--TTTGA---AT---AGACATTT------------------- -----CTCCAAAGAA--------GATATAC---AA-ATGGCCAAT--AAGCACATGAAAA GAT----------GCTCAACATCATTA-GTCATCA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------CTTC----ATACCCACTAGGATGACTATAAT---T A--AAAAG-------ACAGATA-----ATAACA-AGTG--T------------------- ------TGGC-AAGAATGTG----------GAGAA------------------------- ------------ATTGGAACCCTCAT-ACACTGCTGG--TGGGAA--------------- ----------AATGT--A-------------AAAT---TGTTC----CGCCACTTTGGA- ------AAAACAGT---TGGTC--ATTTCCTA--AAAAAGTTAAAC--ATAGAGTTACC- -ATAT---GACCCCCAGCAATTCCA---------------------CTCCAGA--TATA- --------------TA-CCCAAGAGAA------------ATGAAAACA------------ --------------TATATCCAC-ACAAAAACTTGT---------ACATGAA--TATGTT CATA--GGAGCCATTTTCATAA-TAGAAAAAAGGT--G--GA--AACA--ACCCAA---A TGTCCATCA---ACTGATG-----AATGGATAAAC--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATCC----ATACACTAGAAAAT-----T--ATTTT GCAATAA----A-----------------------AAGAATGAAGTACTGATACAT---- ------------------------------------------------------------ --------GCTACAACATGGATGAAC-C---TTAAAAACATTATGCTAAGTGA------- ------------------------------------------------AAGAAGCCAGTC ACAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAGA---------------------------------CCACATAT-TG-------- ---TAT---GATTCCATTCAT-----------AATGAAATTTCC---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AGAAT-------AGGCAAA---------------TCT--------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------GAGACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAA--------GTAGATT------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTGGTT-----------------------------------------------G CTT-------AGGGATGGGG-----------------------GGGGGGGGGGGTGAT-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TGCTAAAGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------TGGGGTTTCTTTTTGGGG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------TGATGAAAAT------------------------------- ---------------GTTCTAAAATTGATTGTGGTGATGGTTGCACA------------- ------------------------------------------------------------ ------------------------------------------------------------ -TATCTGT-GAATATAC------------------------------------------- --------------------------------------------TAAAAA---------- ------------ACATTGAATTGTACACTTTAAATGGGTG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AATTGTATG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------GTATG--TGAG TTATATCTCAATAAGGCTTTTAA------------------------------------- ------ >L1MB7 ------------------------------------------------------------ ------------------------------------------------------------ ------------AGGTGGAGCAAG-----------------ATGGTGAATAGAAGCCCAC ACTATTCAT------------------------------CCCCCAACAAGAA-------- ----------------------------------CACCAAATGTTAACAAGTATCTTCAC -GCAGAAAAGCACCATCACAAAAACAAAAAATCAGATGAGCAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------TCACTGTACTTGGTTTTCACTTCA------TATCACTAGAA------------- ------------------------GAGGCATTAA---------A-GATGGTAGGAAAGAC CATCGTGAATCACC----------AACACCA----------------------------- -------------------------------------------------CCTGTCTCCAT CTTCCAGTAGTGGCTACTCAGTGGAGAGAGTCAG-----TC---TGTGTATGCAGAGGAC AGAGAGCGCAGCAAATGGGGGACTTTACATAGA-------------------ACTCAGTG CTGCCCTGTCACAGAGGAGAGCAAAGCCATGTTGGGCTCGGGCA---------------- ---------------------------------------------GCACCCACATACAGA GGGAGCATGTGGACCAGACTTAGCCAGAGGGGAATTGCCTATCCCAGTGGTTGGAACTTG AG---------------------------------------------------------- ------------------------------------------------------------ -------------------------------TCCCTTAGTAAGC----CATGCCATTGCA GGTCAAAGTGCTCTGGGGTACTATGTAAACTTGAAAGACAGTCTAGGCCGGAGGGACTGT AATTCCTAGGCGACTT-------------------------------------------- -----------------------------------------------CTAGTGCCTGCCT GGACTTAGAGCCTGGGGACCAGGGTGAAACAT-------------GACTATGGAGACACT AGTTGGGTTAGCTAAGGGA-------------GA----------------------GCTT GTGCCACCCCTCCTC------------CAACTCCAG---GCAGTGTGACTCACAGCAACG AAAGTGACTCCTTTCTTCTGCTTAAGGAGAGGACATTGAAG------------------- ------------------------------------------------------------ ----TGTAAAGAGGATTATGTCTTGTATCTTG---------------------------- ------------------------------------------------------------ -------------------------------------------------------GAT-- ---------ACCAGCTCAATCGCAGTAGCATAGAAAATCAAGTAGACTCATGAAGCCCCC ATTCCAG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GTCCCAGCTC-------CCAAACAACATTTCTAAACACAG CCTGGGCCAGAAGAGAACCCA--------------------------------------- --------------------CTGCCCTGAATGGAAGAACCCGGTCCTGACAGGATTAATC ACCTGCTGACTAAGGAGCCCTTGGGCCCTGAATAACTAGCAGTGATACTCAGATAGCATG TCATA-GGCCTTGGGCTCTCATACATGGTCACTACGGGTATGACCT-------------- ------------------------------------------------------------ --------------------------------------------AGCACATTTCTGCCCA TGGTGGCTGTGGTGAAAGACTCTTTCCATTTGAGAAGAGCAGAAGGAAATGTAAAGGGGT C----------------------------------------------------------- -----------------------------------------------------------T TTGTC-----------------TTACACCTTAGGTACCAGCTCAGCCACAGTAAGGTAGA GCAGCAACAAGAAGGTGCTTGGGGTCCCTGAGTTCAAGCCTGAGCCATTAGACAGAAATT TT------------GGATGTTCCCTGGGTAGAGGAGAGCCCCTTGCTCTAAACTATGAGT TCCAGGCCTGGCAGCAATCACGAGCAAATCATAAGCTGACTAAAGAGCCTTAGGGCTTTA AGTGAACATTTGTTGTAGCCTGGCAGAACCCTTCTTCAAAGGAAAAAGGAATCAGCAGAA ATGATCATTATTTGACATGACTCAAATATTACTGA----ATAGAAAAAAACTTTTTCCAA TGGGCATTTATTGAAAAAAATTAGAAACAAT----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------TACTAAACATCATGGATATACCAAATAGTAGAAAACT GTTGGGCAACCAATGAGAAAACAACCGAACTTAAAACTAAAAGGTGAGGGGAAAATATCC ACAAGGAGATTTTGAAAACTATAAAATATTTCTAGAAAACTACATGC------------- --A-----------TAGGATTGTATGTACACTCAAGACTATGTGCATGCTAAGAAAAGAC ATA-----AAAAGGCCCTGAGCTCTCAATCCTGACAAACCTTGAGATTCTGAACAAACAG GAAGTGAAGATTAAAGAAGAAATGTAAAATGTCTGACTAAGTGTTGAAGAC--------- ---------ATGCACAGACATCAACAGTAAGTTACATAGCAAACGCTATGAGACAAATTA AAAAAAAAATAATAAGAAACTTTGTTTAATAATTAGAAGACCACTTTGGTATCTAATCAA AGACCTCTATGGCGGTA-----------------------------------------CC TTAACAAGCCATAAAAATTACAAATAACAT-CAAGAAGAAA-----ATAAAAGAACAACA A---------------------------------------TAAATCCAG--------AAA TAGGTTTTGAGGATGA-------------TGAT--------CAAAAATACGACAGTATGT ATGTAACATT----ACAACTACTCAACTATCCAGTTTCAAGATAT-TAAAAAAAACATAA AGAAAAT----AAT---------ATAAACAGGAAATATACAAACTAATAGAATAGATCAG AGTGGAAGCT--CAGAAATGGATCTTAAAGACTAGGACTTAAAGAATCTCTGATAAAT-- -AAGTGAAAAGAACTAAAAAGAGATAAATAAAAATATTTTAAGAAAACAAAGAGAATAAA AGAATAT------------------TTTTTCATGAAATATTAACTATAATAAAAAAACAA T-AAAAAGAAACAAAACACAAATACTAGAGCTGAAGATCATAAGGACTAGGCCAGAATTT TCAACAGA-----ATTCCTTAATAGCAGAAAAAATCATGCAGAAAGAAGAAAGATCGCCA TTGAATATAAGCCATTTGCAACTACCTAGTCAAAAGA------GAAAAAAAAATAAAAAA ----------AAAA---------------GAAAAAACACCAGAAACATCAAA--TTCTG- GATT----TGAAA---------TATAC---AATAATTGAAATTAAAACTTCACTAGAG-- ---GGGCTCAACAGCAGA----------------TTTG--------------------AA A--TAGC------------------AGAAGAAAG-AAT-TAGCA--AACTTGAAGAT--- -AGGTCAATAGAGA-T-----TATCCAATCTG---------AAGAGCAGAAA---GAAAA AAGA---ATGAAGAAA-AA---------TGA---ACAGAGCCTCA--GAGACCTGTGGG- AAACC--------A---TCAAGTA--TACCAACATATTC--A-TAATGAG--AATC---- ----------CCAGAAG---GAGAGGAGAGAAAA---AAAGGGAAGG---------AAAG AATATTT---GA-----AGAAATAATGGCC--GAAAATTTCCCAAATTT----------- ---------GATGAAAAACAT--TAAT--CTACACATTTCAAAGAAGATACATG------ ---------------------AATTCAT-AAC--------------AAAGAGATCCACAC C-------T---------------------AGACACATCATAATCCAATT------GTC- AAAAGACAAAG-----------AAAAAATTTT---------------------------- -------------TAAAAGC--GGCAAAAGA---AAAAGAACTATT-------------- ------------AC---TTACAAAGA-ATCATTAA--------------TAAAATT--AA CAGTTGATTTC-----TCATCAGAA--ACCATG-GAGGC------CAG-AAGGCAGTG-- -----------GGA-TGACATA-T-------TCAAAG--TGCT-------------GAAA GAAAA---------------AAAAAA--TCA--ACCAAGAA--------TTC---TATAT CCA-----------GCAAAACTATCC-----TTCAA-AAATGA-------AG-------- ------------------------G-AGAAATTAAGACATTCCCAGATAAAC-AAAAACT GAGAGA-ATTTGTTGCTAGAAGAC---CTGCCTTAC-AAGAA------------------ --------------------ATACTAAAGGG----------------------------- -----------------------------------AGTTT-------------TTCAGGC TGAAGGAAAAGGCGGATAGTATGTCCAAATTAAAGAAGTACAAAAGCTAAAACTGAAAAC AAAATAAATAGTATTCCTAATCATCAAAATTTAAAAATGAATGATTAAAAGACAA----- -------------------------------CCAAAAATAACAAATAGTATTAAACTTCA TCAGATCGGAATAAA---------------------AAGACAT------AGGAAAAGTAA TTGAGGAGGCTGGAATGAAAAAACATTAACTGTAAAGG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GGAAC AAAATTACAAGGTAAAAGAACCCTTGAAATAGTAAATAGAAAGTAAATTATAAAAGTCTA AATATTTTTT-----------------------------------------------TTT ATTTTCTTTCTACTCTTATCTAAAAAATAAAGGACAACAGAATAAAAATAATTGAAAGAT TATTGTCTTAACTTTTTAAAACGTGTAATTTGTGTGAAAAAACAGACAAAGAAAGGGTGG GGAGATGAGA-------------------------------------------------- -----------------------------------------------------TTTTATT GAACAAAGTTTTTG---TATACTGTTGAAATTAAGTTGGTATTAACTTGA---------- --------ACTA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------TTGTTTTAAG-------------------------TTAAG GTGATTATT-----------------------------------------ACATCCCCTG GAAAACCCAT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GAAAAAATCA AAGCAAAATAATAAAA-AAAAAGAAAAATAATAAACTATAAGATAAAAAATCCAAACTAA ACAAAAGAGAAATTAGTTGAT--------------------------------------- ---------------------AAAAAAAAGAAGA--------------AA---AAAAGAA GAAAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------ATA------------------------------------- ------------------------------------------------------------ --------------------TATAACAAA----AAAATTTAT-AATAAAT-------ATT AAAT--GGATA--AAAT-----CTCCATT----------------AAAAGAC------AA AGATATATAAAA----AATGATATTGGAAGGTA------AAAA---ATACATGATCTAA- ---CTA-------TAT-GCTGTCTA-CAAGAGACACACTT-TAGAT--TTAAAGACACAA A-TAGGTTGAAAGTAAAAGGA---T------------GGAAA----A-AAATATACCATG C--------------AAATAG------TAACC---------------------AAAAG-- -AGAAGGAGAGT----GTGTATACTAATAAT-AGACAAAATAGACTTTAAG--------- ----AAAAAAATTT-TTACAAGAAAA-AAAG-AAGTATAT------TATAT------AAT GATAAA---AGGGTCAATC------CATCAA---GAAG--------AT-ATAACAA-TTA TAA-----------------A----CATATATG---------TACCTAACAACAGAGCCC CAAA--ATA-TATGAAAAAAAAAATGACAGAATT--AA----AGGAAGA---------AA TAGACAATTAA------AAAATAATAGTTGGAGACTTCAATA----------------CT TCACT------ATCAAT-AATAGATAGAACAA---------------------CTAGAC- -----AAAA-------------GATCAACAAGGAAAT-----AATTGAAC-AACACTATA AA------CCAACTAG---ACCTAACAGATATCTATA--GA----ACACTCCACCCAACA ---------------------------TTTTCAACTG-----CACATATAGGAACATTCT -------CAGGATAGAACATATATTAGGCCATAAAACAAG-------------------- -TCTCAATAAATTTAAAAAGA--TTGAAAT----------------CATACAAA------ -ATATGTTCTCT---AATCACAATGGAA-TGAAATTAGAAATCAAT-------------- ----------------------------------------------AACA--------GA --------------AGGAAAATTTGG---AAATTTAAAAA----AAATTTGAAAA--T-T AAAAAAAAAA-TTCTAAAA---AACAACAAAG--GGTAAAAAAAGA--AAT--T-AAAAG GGAAATT---------------AGAAAATACTTT---GAGAT------------------ ------AAATGAAAATAA-AAA------------CACAAC--ATACCAAAATTTA-TGG- GA-----TGCAGCTAAAGCAGTG-----------------------------CTTAGAGG GAAA--TTTATAGCTGTA----AATGC----CTACATTAAAAA-----AAAAAAAATCT- --CAAATCAAT-AACCTAA-CCTTCCACCTT---AAGAAAC--TAGAAAAAG------AA AA--------AAAAATAC-------------CCAAAAC--AAGCAGAA-AGAAGGAAATA ATA---AAGATTAGA-------------------AGAGAAATA---AA-T-GAAATAGAG AATAG------AA------------------------------------AAG-------- --AAAAAATA-A---------AAA----AAACAA-AAAGTTG------TTTTTTTGAAAA GATCAA------------------------------------------------------ --------------------------------CAA-----AATTGACAAACCT---TTAG CTA------GATTGA--CCA------------AGAAA------------------AAAAG A---GAAA-AAATTC-----------------AAATTAC--------TAAAA-----TC- ---------AGG-AATGAAA--GA----------GGGGA---CATTACTACTAACCTT-A CA-GAAATA--AAAAGAAT-TATAAA---------GGAATACT--ATAAA---------- -----------CAA---TTGTATGCCAACAA---ATTAGATAACCTAG---ATGAAAT-- GGACAAATTCCT----------AGAAAGA---------CAC-----AAACTACCA----- -AAACTGACTCA---AGAAGAAATAGAAAATCTGAAT----------------------- AGACC------------TA-TAACAAATAAAGAAATTGAAT-T---------AGTAAA-- -TAAAAAACTTCC------CACAAAGAAAAC---CCTAGGCCT--GGATGG--------- ------------CTTCACT-GGTG--AA-------------------TTCTA-------- ----CCAAATATTT---AAAGAA-GAATTAA--AA-CCAATC----------CTTCACAA ACTCTT----CC---AAAAAATAGAA------AAGAAA-AG-----------AACACTTT CCAACTCATTCT-----ATGAGGCC-----AGTAT---TACC----ATAC---------- ----------------------------------------C--AAAAC-------AAGAC AAA---------------------AAA---ATAACAAAAAA---AGAAAACTAT------ -------------A-GACCAATAT---CCC----TTATGAATATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AAC-AAAACA------------------AA--TC--------------CA--ACA----- --------ACATATA---------AAAAGGATTATATA--CCATGAC------------C AAG---TGGGA-TT----------TATCTCA------------GA--GATATAAGAGTTG -T----------------------TT-AAC-----ATTAAA--AAATCAATAAA--TGTA ---ATACACCATAT------TAATAG----AATAAAGGACAAAAAC---CACATGA---- -TCATCTCAATA---GATGC---AGAAAAAACATTTGACAA---AATCCAACACCCTTT- ---------------CATGA---------T---A--AA-----AACACTCAAC---AAAC TAGGAATAGAAGGGAACT-----TCCTCAACCTGATAAA--------------------- ------GGACATCTAT-GAAAAA--------CCCACAGC-----------TAACAT--CA TACTTAATGGTGA-----AAG-ACTGAAAGC----TTTT---CTC----CT--AAGATTA GGAACA----AGACAAAG-ATAT--CCATTT----------------------------- ------------------------------------------------------------ ----------------------------------TTACCACTTCTATTC---AACATTGT ACT---GGAGGTTCTAGCCAGGGCAAT--------TAG-GC------AAGAA---AAAGA --AATAAAAGGCATCCAGATTGGA---AAGGAA------GAAGTAAAA--C--------- ------TATCTCTA-TT--T---GCAGA------TGACAT------GATCTTATATATA- -GAAAATC--CTGAAAA---AAAAAAAA---------A---------------AA--AAA TATTAAAGCT---------AA--TAAATAAATTCAGCAAGG--TTA-----AAGAATAC- --AA-------------------------------AATCAA-------------TAT--- AAAAAAA-----CATT-------------------------------------------- -----TGTATTTC--TA-TACACTAGC---------------AATGAATAAT-----CCA A------------------AAATGAAATTTA------GAAAAATTTCTATTTACAATAGC ATTA------------------AAAAGAATA---------AAA----------TAAAAAG AAATTT--------AA--C-AAAAGAAGTG---A---AAGACTTGT---ACAC-TGAAAA CTACAAAACAT------TGTTG-AAAGAAATTA-AA------------GAAG-------- ------------ACCT--AAAT--AAA---TGGA---AA--AACAT----------CCA- --TGTTC------ATA-GAATTAAAAAATT-----AATTTTTT----------------- TAAGAAGG-----------------------------------------GAAAT--ATTT CCC-AA--ATTGATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--C---------------------CCAGCT-TG---CTTTTT ------------------------------------------TGCAGAAATTG------- ----------------------ACAAGCTGAT------CCTAAAA---TTCATATGGAAA T-------GCAAGGGACCCA---GA--ATAGCCAAAACAATTTTGAAAA---AGAA--GA ACA---AAGT--T-------GGA--GGACTCACA---CTTCCCAATTTCAAAAT-----T TACTAC-------------------------AA---AGCTACAGT-AATCAA---GAC-A GTG--------------TGGTACTGG--------------------CATAAGAGACA--- ---AATAGAT--CA---ATAT-AATAGAATTAAAAATCC------AA---AAATAAAA-- -CCAT----------------AAA-------TTTATGG----TCAAAT--TAATTTT--- AACAAAAGGGTCCAAAGACAATTT--A-------------------ATGAG--GA---AA GA------------ATAGTCTTTT--CAAAAAATGG---------------TGCTGATAT CCACATGCAAAAAA--------ATCAA---------------CACGC-AAAAAA---ATA ---------AATTTGGACCTT---CACCT-----------CAAACC--AAA--A---ACA AAAAATTAATC-AAAAATGG---AT---CATAGAC---CTAAATGTA--AGAGCTAAAAT TAT------------------------AAAACTCTTAGAA---------------GAAAA ---CATA------G------------------G-AATAAATCTTTGTGACCTTG--GAT- -----TAGGCAATGGTT-----TCTTAGATAT-GACACCA---AAAGCACAAGAAAC--- --AAAAAAA---AA----AAT---AGATAAA-TTGGAC----------TTCATCAAA--- ATTAAAAA------------------TTT-TTTTG-------TT--------------TC AAAAAACACCAAT-------------AAAAAAAAGAAAAAA------------------- ------A-------------AAACCT------AAAAAA--T-GAGAG-AAAAAATATTT- --ACAAATCATATAT--------CT-------GATAAAGGTC--------TA--GTATC- ---CAGAATATATAAA-GA--ATTCTT---ACA------AC--TCAAT------------ --------------------AATAAAAGGGATAAA--GATT----TGAA---AAAAAGGC C--AAA---------AGT--TTTAA---ATGGAAGACATTT------------------- -----CTCCAAAGAA--------GATATAC---AA-ATGGCCAAT--AAGCACATGAAAA GAT----------GCTCAACATCATTA-GTCATTA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------CTTC----ACACCCACTAGGATGGCTATAAT---- ---AAAAA---------AAACA-----ATAATA-AATG--T------------------- ------TAGT-AAAAATGTG----------GAGAA------------------------- ------------ATTGAAACCCTCAT-ACATTGCTGG--TGGA----------------- ----------AATGT--A-------------AAAT---GGTAT----AACTTTTTGGG-- ------AAAACAGTT--TGGTA--GTTTCCTA--AAAATGTTAAAC--ATAAAGTTACC- -ATAT---GA--CCCAGCAATTCCA---------------------CTCCTAGG-TATA- --------------TA-CCCAAGAGAA--------------------------------- --------------TATGTTCAC-ACAAAAACTTGT---------ACAATA---AATGTT CAAA--GAAGCATTATTCTTAA-TATAAAAAAAGA-----GA--AAAA--ACCCAA---A TGCCCAACA---ACTGATG-----AATAGATAAAC--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATCT----ATACAATGAAATGT------------- -CCAGAA----------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------TAGGCAA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ATCCAT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------A-- ------------------------------------------------------------ ------------------------------------------------------------ ------GAGACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAA--------GTAGATT------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTGGTT-----------------------------------------------G CCA-------GGGGCTGGGA----------------------GGGGGGAATGGGGAGT-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CTGCTAATGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CGGGGTTTCTTTTTGGGG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------TGATGAAAATG------------------------------ ---------------TTCTGGAATTAGATAGTGGTGATGGTTGCACA------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACTCTGT-GAATATAC------------------------------------------- --------------------------------------------TAAAAA---------- ------------CCACTGAATTGCACACTTTAAAATGGTG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AATTTTATG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------GTATG--TGAA TTATATCTCAATAAAGCTGTTATTT----------------------------------- ------ >L1MB5 ------------------------------------------------------------ ------------------------------------------------------------ --------------CCGTTCCAAG-----------------ATGGCCGAATAGGAACAGC TCCGGTCTG---------------------------CAATTCCCAGCATG---------- ---------------------------------------ATCGAGACAGAAGACAG---- -----------GTGATTTCTGCATTTCCAACTGAGGTAACTGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------TTCATCTCATTGGG------ACTGGTCGGAA------------- --------AGTGGGTGCAGCCCACGGAGGGCGAG---------C-CAAAGCAGGATGGGG CATCGCCTCACCTG----------GGAAGTG----------------------------- -------------------------------------------------CAAGGGGTGGG GGGATTTCCCTTTCCTAGCCAATGGAAGCTGTGA-----CA---GACTGTACCGGGAAAA TCGGGAGACTATGATTCTAAACACTGCGCTTTTC------------------CAATGGTC TTAGCAAATGGTACACCAGGAGATTATATCCCACACCTG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCTCAGTGGGTCC---------------- -------------------------CATGCCCACAGAGCCTTGCTCACTGCTAGTCCAAG ATGGAACTGCAAGGTG-------------------------------------------- ------------------------------------------------------------ ---------GCAAGCCTGCCTGGGGGAGGGGC-------------GTCTGCCATTGTTGA GGTTTGAGTAGGTAA--------------------------------------------- ---------------------------------------ACAAAGCAGCCTGGAAGCTTG AA-------------------CTGAGTGGAGCCCACCGCAG------------------- ------------------------------------------------------------ ----CTCAACGAGGAC-------------------------------------------- ------------------------------------------------------------ ----------------------------------------CACCTGCCTCTGTAGACT-- ---------CCACCTCTGGGGGCAGG-GCATAGCTGAACAAAAGGCAGCAGAAAC----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TTCTGCAGAC-------TTAAATGTCCCTGTCTGACAGCT CTGAAGAGAGCAGTG--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTTCTCCCAGCATGGTGTTTG AGGTCTGAAAAGGG---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ACAGACTTATAAATCAACTGTCTCAAATATGCT----TAAATAGTAAAAGAT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------TAAAAGACA-----------TTGGAAAAAAAAAAAAA AAAAACTAAATAAAACTAAAAGCACAATTAATAAAAAAATAGGAAATCAATAAAAAGATA GCAATATAAAAAGTAATCAAAAATAAATTCTTGATATGAAAAGAAAAAAAATTAAAATTC AAA-----------ATTTACTAAAAAAGAACAAAAGAAAATTTAA--------------- ----------------------------------------------GCAAACAAAATAAA AAAACAAAAAATAAGAAAAAAAAACAAATAAAATTAACATAAATAAAAAAG--------- ---------AAAAATAAAT----------------------------------------- -TAAAAAAAAATAAATAATATATAATAAATAAATAGAAAATCCCAAAAGGGGCGAAGAAA ------------------------------------------------------------ -------------------------------TGAGTAAAGG-----CAGAAACAGAAGGG TAGGA-----------------------------------GAGAATAAA--------AAA AAGAGGAAGAACGTCTTTTTAAATAATGGCACCAAACCTCCCAAAATTAAAGAAAGA--- -------AAT----GAAGCTACTTATT----------------CCGATGAATTAATGAAC TTTAAGT----AAAAAAAACTCGAAA---AAAATCCCTCTGAGATAATAGTAAA------ ------TG--------------TTGAAAGCCATAATAAAAAAGAAAATCTTGAAAGCAGC AGAATAAAAGGAAGTCGGCACAAACATGGGG----------AGAAACCAGAGC-----AG AAAAGCT---------------------------------------------GAAAATTC TAAAAAACA--------------------------------------GAGCGCCCCTTCT TCTCCAAA----------GGATCGCAGTAAGAGACC------------------------ -------------------------------------------AGCAACACACCAAAGCA ----------GGAG---------------TGAAACA------------------TTTCAA AAGC----CGAAA---------TATAC---AAGTGATAAAATGAAAAAAAATATTGAA-- ---ACCCTCAACACAAAA----------------ATAG--------------------AT C--AGGC------------------AGAAGAAAG-AAT-TAGTG--TGCTTGAAGAT--- -AGGATAATTGAAA-T-----TACAGAGGCAG---------AGGAGATAAAA---GAAAA AAAA---ATAAAAAAA-AA---------TGA---ACAAAACCTAA--AAGAAATGTGGG- ACAAT--------G---TCAAAAT--GGCAAATCTAAGA--T-TAATTGG--CCTT---- ----------CAAGAAGAGGACAGAGAGAGAGGA---ATAATGGTAG---------AAAA TTTATTC---AAT----AAACATAATAAT---GAAAACTTTCCAAAATT----------- ---------GATAAAAGACAT--TAAT--CTACACATCC-----AAGAAGCTCAAAAA-A CGCCAAGCA------------GAATAAA-CTC--------------AAAGAGAACTACAC C-------A---------------------AGACACATAATAATCAAATT------GCC- AAAGGAGAAAG---AGAAAG--AGAGAATCC----------------------------- -------------TGAAAGC--AGCAAGAGA---GAAGATACCTTT-------------- -----------GATTCATTATGAAGG-GGCCATCA--------------TAAATCT--AA CAACAGATTTT-----TCATCAGAA--ACCATA-AAGGC------AAG-GAGACAGTG-- -----------GGA-TGAAATA-T-------TTAAAG--AGCT-------------GAAA GAAAA---------------AAAATT--TCA--ACAAAAAA--------TTC---TATAT TCA-----------GCAAAACTATTC-----TTCAA-AAATGA-------AG-------- ------------------------A-AGAAATTAAGGCATTCCCAGATAAAC-AAAAGCT GAGAGA-GTTTATTGCTAGTAGAC---CTGCCCTAC-AAGAG------------------ --------------------CTCCTGAAGGAAG--------------------------- -----------------------------------AGTCC-------------TTAAACA TGG----------------------------------------------------AAAGG AACA---------------ACCGGTA---------------------------------- -------------------------------CCAGCCACTGCAAAAACTAAGCAAAGAAT TGAACAAAAAAATTGTCAACCGAAAATCATAAATTGAAAATAA--------AATTCTTCA AAACGAAGGAGAAATTAAGACATCCCTCGATAAACAAAAGATAAGTGAGTGCATTCCTTG CTGGTACACCTGCCCTATAAGAAATGCTAACAGGAGTCCTTCAAGCTGAAATGAAAGGAC ACTAGACAGTAACTCAAAGCTACATGAAGAAATAAAGAACACTAGCAAA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGTAACTACCTAGGTAAATATAAAATACAGTATTAT TATATTTTTGATTTGTAATACCTCCTTTTCTCTATTAGATTTAAAAGACAAATGCATAAA ACAATCATTA-------------------------------------------------- -----------------------TAAATCTATTTTGACGGGCACACAATGAATAA----- --------------------AGATGTAATTTGTGACAACAACAACATAAGGGGACGAAAG GAGCTTTTTAAGGAGAAA------------------------------------------ ------------------------------------------------------------ ------AGTTTTTA---TATATAATTGAGATTAAGTTGATATTAATTCAA---------- --------ACTA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------TTGTTTTAAA-------------------------TTTAA CTATGTTAATTGTAATCCGCAGG---------------------------ATAACCACTA AGAAAAGAAA-TAAAAATAAATCAATAAAAAGGAA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AACAAAGAAT AAAAAATGGTATTCTACAAAAAAACTATCTAAAAACAAAAGGGAGGAATTGTAGAAGAAT TGAGGAACAAAAA----------------------------------------------- ---------------------AAAATGACATATA---------------GCACACAAATA ACAAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------TGACA-------GGAGTAAGT--------------------- ------------------------------------------------------------ --------------------CCTTTCTTA--TCAATAATTAC-ATTAAAT-------G-T AAAT--GGATT--AAACTC---TCCAATT----------------AAAAGAC------AA AAAT--TGGCAA----AATG---------GAT-------TAAA---AAACAAGATCCAT- ---CTA-------TAT-GCTGTCTA-CAAGAGATTCACTT-TAGAT--CCAAAGACACAA A-TAGGTTGAAAGTAAAAGGA---T------------GGAAA----A-AGATATTCCATA TAA------------AAATTA------AAAAC---------------------AAAAGAG AGGTAG--GAGT----GGCTATACTAATATC-AGACAAAATAGACTTTAAG-TC------ ----AAAAATTA---TTACAAGAGAC-AAAG-AAGGACAT------TATAT------AAT GATAAA---AGGGTCAATT------CATCAA---GAAA--------AT-ATAACAA-TTA TAA-----------------A----CATATATG---------CACCCAACAACAGAGCCC CAAA--ATA-TATAAAGCAAAAATTGACAGAATT--GA----AGGGAGA---------AA TAGACAGTTCT------ACAATAATAGTTGGAGACTTCAATA----------------CC CCACT------TTCAAT-AATGGATAGAACAA---------------------CTAGAC- -----AGAA-------------GATCAATAAGGAAATAGAGGACTTGAAC-AACACTATA AA------CCAAATAG---ATCTAACAGACATATATA--GA----ACACTCCACCCAACA AC---AGCAGAATATACAT------TCTTCTCAAGTG-----CA--CAT-GGAACATTCT --C----CAGAATAGACCATATGTTAGGCCACAAAACAAG-------------------- -TCTTAATAAATTTAAAAAAA--TTGAAAT----------------CATACAAA------ -GTATATTCTCT---GACCACAATGGAA-TGAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------GA --------------AGA-AAAACTGG---AAAATTCACAA----ATATGTGGAAA--T-T AAACAACATA-CTCTTAAA---TA-ACCAGTG--GGTCAAAAAAGA--AAT--C-AAAAG GGAAATT---------------AGAAAATACTTT---GAGAT------------------ ------AAATGAAAATAA-AAA------------CACAAC--ATACCAAAACTTA-TGG- GA-----TGCAGTAAAAGCAGTG-----------------------------CTCAGAGG GAAA--TTTATAGCTGTA----AATAC----CTACATTAAAAAAG---AAGAAAGATCT- --CAAATCAAT-AACCTAA-CTTTACACCTT---AAGGAAC--TAGAAAAAG------AA AA-----ACAAAATAAAC-------------CCAAAGC--TAGCAGAA-GGAATAAAATA ATA---AAGATTAGA-------------------GCAGAAATA---AA-T-AAAATAGAA TATAA------AA------------------------------------AAA-CAA---T AGAAAAAATTAA------------------------------------TTTTTTTAAAAA GATCAA------------------------------------------------------ --------------------------------CAA-----AATTGACAAACTT---TTAG CTA------GACTGA--CAA------------AGAAA------------------AAAAA AAGAGAAA-AGACTC-----------------AAATTAC--------TAAAA-----TC- ---------AGA-AATAAAA--AT----------GGGGA---CATTACTACTAACCTT-A CA-GAAATA--AAAAGGAT-TATAAG---------AGAATACT--ATGAA---------- -----------CAA---TTGTATGCCAACAA---ATTAGATAACCTAG---ATGAAAT-- AGACAAATTCCT----------AAAAACA---------CAC-----AAACTACCA----- -AAACTGACTCA---AGAAGAAATAGAAAATCTGAAT----------------------- AGACC------------TA-TAACAAGTAAAGAGATTGAAT-C---------AGTAAT-- -AAAAAAATTTCC------CACAAAAAAAAA---CCCAGGACC--AGATAG--------- ------------CTTCACT-GGTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAAAAA-AAAATAA--AAATCATTT----------TTCTTCAA ATTTTT----C----AAAAAATAGAA------AAGGAA-GG-----------AATACTTC CTAACTCATTCT-----ATGAGGCC-----AGCAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAGC-------CAGAC AAA---------------------GAT---ATCACAAGAAA------AAAATAC------ -------------A-GACCAATAT---CCC----TTATGAATATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACCT------------------AGAATCC-------------CA--GAA----- --------GAAAATA---------AAAAGAATTATACA--CCATAAC------------C AAG---TGAGG-TT----------TATTCCA------------GG--AAAGCAAGGGTTG -T----------------------TTAAATTCAAAAAAAAA--AAATTAATCAA--TGTA ---ATACACCACAT------TAATAG----AATAAAGGAAAAAACC---CATATAA---- -TTATCTCAATT---GATGC---AGAAAAAGTATTTAACAA---AATCCAACAACCTTT- ---------------CATGA---------T---T--AA-----AACACTCAAC---AAAC TAGGAATAGAAGAGAACT-----TTCTCAACATGATAAA--------------------- ------GGGCATTTAT-GAAAAA--------CCCACAGC-----------TAACAT--CA TACTCAATGGTAA-----AAG-ACTGAAAGC----TTTT---CCC----CT--AAGATCA GGAACA----AGACAAGG-ATGC--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTCTATTC---AACATTGT ATT---GGAAGTTCTAGCCAGAGCAAT--------TAG-GC------AAGAA---AAAAA --AATAAAAGGCATCCAAATTGGA---AAGGAA------GAAGTAAAA--C--------- ------TATCTCTA-TT--T---GCAGA------TGACAT------GATCTTATATATA- -GAAAAAA--CTAAAGA---AACAACAA---------A---------------AA--AAC TAATAAAACT---------AA--TAAACAAATTCAGCAAAG--TTG-----CAGGATAC- --AA-------------------------------GATCAA-------------CAT--- ACAAAAAT----CAGT-------------------------------------------- -----TGTATTTTTATA-TACACCTAA---------------AAAAAAAAAT-----CTA A------------------AAAATAAAATTAAA----AAAACAATTCCATTTATAATAGC ATTA------------------AAAAGAATA---------AAA------TACTTAGGAAT AAATTT--------AA--C-CAAGGAGGTG---A---AAGACTTGT---ACAC-TGAAAA CTACAAAACAT------TGCTG-AAAGAAATTA-AA------------GAAG-------- ------------ACCT--AAAT--AAA---TGGA---AA--AACAT---------CCCA- --TATTC------ATG-GATTGGAAGACTT-A---A---TATT--------------G-- TTAAGATG-----------------------------------------ACAAT--ACTC CCC-AA--AGTGATCTACA-------------------GA---TTCAATGCA---ATC-- ------T-CTATCAAAAT--C---------------------CCAATG-AC---CTTTTT ------------------------------------------TGCAGAAATGG------- ----------------------AAAAGCTGAC------TCTAAAA---TTCATATGGAAT T-------TCAAGGGACCCA---AA--ATAGCCAAAACAATTTTAAAAA---AGAA--GA ACA---AAGT--T-------GAA--GAACTCATA---CTTCCTCATTTCAAAAC-----T TACTAC-------------------------AA---AACTACAGT-AATCAA---AAC-A ATG--------------TGGTTCTAG--CA------------T---AAGGATAGACA--- ---TATAGAT--CA---ATGG-AATAGAATTGAGAGTCC------AG---AAATAAAC-- -CCAT----------------ACA-------TCTATGG----TCAATT--GATTTTA--- AACAG---GGTTCCAAGAACATTC--A-------------------ATGGG--GA---AA GA------------ATAGTCTCTT--TAACAAATGG---------------TGCTG---- ------GGGAAACA--TGG-ATATCCA---------------CATGC-AAAAAA---ATG ---------AAATTGGACCCC---TTCCT-----------CACCCC--ATA--T---ACA AAAA-TTAATT-CAAAATGG---AT---CAAAGAC---CTAAATATA--AGAGCTAAAAC TAT------------------------AAAACTCTTAGAA---------------GAAAA ---CATA------G------------------G-GATAAATCTTCATGACCTTG--GAT- -----TTGGCAATGGTT-----TCTTAGATAT-AACACCA---AAAACAATAGCCAA--- --AAAAGAA---AA----AAT---AGATAAA-TTGGAC----------TTAATAAAA--- ATTAAAAA------------------TTT-TTGTA-------TA--------------AA -AAAAAAAATTAT-------------CAAGAAAGTGAAAAG------------------- ------A-------------CAACTT------ACAGAA--G-GGGAA---AAAATATTT- --GCAAATTATATAT--------CT-------GATAAGGGTC--------TA--GTATC- ---CAGAATATATAAA-AA--ACTCTT---AAA------AAATCAAAA------------ ---AAA--------------AAAAAAAAA--------AACCCCAATTAT---AAAATGGG C--AAA---------ATA--TTTGA---AT---AGATATTT------------------- -----TTTCAAAGAA--------GATATAC---AA-ATGGCCAAG--AAGCACATGAAAA GAT----------GCTCAACATCATTA-ATCATTA------------------------- -----GGGA-AATGAAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------CTTC----ACACCCAATAGGATGGCTATAATTTTT ATTAAAAAAAATAAGGAAAAAGGGTAAATAACA-AGGG--TTAGGATGTGGAGAAAGAAG CTAGTATGGA-TAGGAGGTG----------GAGAA------------------------- ------------ATTGGAACTCTATT-ACATTGGCGGGTGAGG----------------- ----------AATGT--A-------------AAAT---GGTAC----AGCCATTGTGG-- ------AAAACAGTT--TGGCA--G-TTCCTC--AAAAAGTTAAAC--ATAGAATTACT- -ATAT---GA--CCCAGCAATTCCA---------------------CTTCTAGG-TATA- --------------TA-CCCAAAAGAA------------ATAAAAACATGTTTACACAGA TACTTGTGCACCAGTATGTTTA--ACAAAACCTTGT---------ACATG----AATGTT CATA--GCAGCATTATTCACAA-TAGCCAAAAGGC--A--GAGAAACA--ACCCAA---A TGCCCATCA---ACAAATG-----AATGGATAAAT--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAC----ATACAATGGAATAT-----T--ATTCA GCCATAA----AA----------------------AGGAATAAAGTACTGATACAT---- ------------------------------------------------------------ --------GTTACAACGTGGATGAAC-C---TTGAAAACATTATGCTAAATGA------- ------------------------------------------------AAGAAGCCAGAA CCAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAGG----------------------------------CCAATAT-TG-------- ---TAT---GATTCCATTCAA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TGAAATATCCAGAATAGGCAAA---------------TCC--------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------GAGACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAA--------GCAGATT------ ------------------------------------------------------------ ------------------------------------------------------------ -----GGTGGTT-----------------------------------------------G CCA-------GGGGCTGGGG-------------------GGAGGGGGGAATGGGGAGT-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------CTGCTTAATGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CGGGGTTTTCTTTTGGGG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------TGATGAAAATG------------------------------ ---------------TTTTGGAATTAGATAGAGGTGGTGGTTGCACA------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACATTGT-GAATGTAC------------------------------------------- --------------------------------------------TAAATG---------- ------------CCACTGAATTGTACACTTTAAAATGGTT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AATTTTATG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------TTATA--TGAA TTTCACCTCAATTAAAA------------------------------------------- ------ >L1MB1 ------------------------------------------------------------ ------------------------------------------------------------ ------------GAGTTCCGCAAG-----------------CTGGCAGAGTGGGAAGCCC TAGATTCTC--------------------------CTTCCCTTCACAAACAC-------- ----------------------------------ACCGATTGAGCAACAATTCATG---- -GACAAATTCC------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CTTTTTAA------GAAATTCAGAA-------ACTAAT TGAAAGGCTCCTGCACCCTTGATGAGTGTGAAAC---------C-AGACTCATCAAAGCT GATAGGGAAATTCA----------AGACACCCTCTCACCAGAATCTCTACCCCTGGCACA GTT-------------------------------------CCATACAATAGGGACGAGAC CCCTCATCCCTCAGCTTCTCTGAGGAGAAGGAAA-----GG---GGTATTAACTAGGTTC AACGC-----------------------------------------------TCTACCTT TTTCTGGGGGTACCCAGAGGACTGGGCTCTCCCTAGCCTGCGTTG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGTCC----TACGCGGA---- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------CTGGTCT AAGCCTGCAGGCTAAAGGGGAAGAGGGATTGT-------------GGTTTGGAACTGGTG GACCCCATAGACCCCCCCC----------------------------------------- ----------CTGGC------------TCGGCATAA---ATCAGAGGGATGAAAAACCCC AG---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CTCTTA-- ---------GCTTCTCCCTGGGGAGGAAAAGAGTTGGACAACGGATCCAATGACCCAACT TTTCGGGGGACATCCGAAGAAATTGCATTCAGCTCCTCTA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------TCCTGGAACT-------CTGGTGGGGTCGGTACAGGCCTG GACAGGTGAGGAGGACA------------------------------------------- -------------------------------GAAG------------------------- -CATTGGCTTTGAATACTCTAACTTACCCACATCTCACAACTCGACATCTAGGAAAGCCA GGGTA-ACCCCAGCGTCCGGCGGCTCTATGGGT--------------------------- ------------------------------------------------------------ --------------------------------------------AGGAAAAAAGGTTTGG GAGGACTCCAGAATCTCTAGCCAGGCTGATTGGTGAAGGTCTT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TTTCTGTACAAGGCCAGTCTG TGAAGTCTGGGAAG--------------------------------AGTGTTTTTTTTCT TT---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------TGCAGAAAG-----------TGGACGACACAAAGT-- ------------------------------------------------------------ -------------------GCCAAAGAAAATGAAAAATCAGGCAAAG------------- --A-----------TGTTCCAAATAAAGGAACAAAATAAATCT----------------- ----------------------------------------------CCAGAAACCA---- ---------------------------------------ACCCTAACGAAA--------- ---------TAGAG---------------------------------------------- -ATATATAATTTACCTGACAGAGAATTCAAAATAACTGTCATAAAGTGTTTCATGGGGGC AAA--------------------------------------------------------- -------------------------------TGAGGAGAAA-----CCAGAACACAAACG CTG-------------------------------------AAAATTCGA--------AAA ACCA----GAGCGCTT-------------CTTC--TCCT--CCAA---A-AG-------- -------ATC----ACACTTGCTC-------------------GC-CAG---CAATGGAT CCAAACT----GG------ACGCAAG---AAGAAATCGCTGAATTGCCAGAAAA------ ------AGAC------------TTCAGAAGGTTAGT-TATTAAGCTATTCACGGAGCT-- --ACCAGAGAAAGGT--------------------------GAAACCCAACGC-----AA GGAAATT---------------------------------------------AAAAAACT T-AAAATAA-------------------------------------------------AG GTTATGGA----------TGAAATATTCACTAGA-------------------------- -------------------------------------------ATAAAAAGTTTAGAGAA ----------AAAC---------------CAAAAAG------AAC---------TTTTG- GAGC----TGAAA---------AGCAC---ACTAATAAAAATACAAAATTCACTCAAA-- ---GGATTCAAAAGCAGA----------------TTTG--------------------AT C--AGGCACAGACTAGATTAAATAGAGAAAAAAG-AAT-CAGAA--AACTGAAAGAC--- -AAAGTATTTGAAA-T-----TATCCAGTCAG---------AGGAGCAAAAA---GAAAA AAAA---ATGAAAAAT-AA---------AGA---AGAAAGCCTAA--GGGACTTATGGG- AGTTC--------A---TAAAACA--CACTAAAATATAC--A-CAATAGG--AGTC---- ----------CAAGAGAGCCAGAGAAAGAAAGGA---AAAAAGGTAG---------AAAA CTTATTT---AA-----AGAAATAATGGCT--AAAAACTTCCCAAATCT----------- ---------GGGGAAAAAAAA--AGAA--ATCCAAATTC-----AAGAAACCCAAAGA-A ACCCAAAAA------------AAATGAA-CTC--------------AAAGAAATCCACAC C-------A---------------------AGACACATTATAATCAAATT------GTC- AAAAGTCAAAG---ACAAAG--AGAGAATTT----------------------------- -------------TGAAAGC--AGCAAGAGA---AAAGCATCATGT-------------- -----------TAC---ATACAAGGG-GAAATCCA--------------TAAGAAT--AA CAGAAGATTTC-----TCAGCAGAA--ATCTTG-CAAGC------CAG-AAGGAAGTG-- -----------GGA-TGATATA-T-------TCAAAG--TGCT-------------GAAA GAAAA---------------AAAATT--CCA--ACCAAAAA--------AAA---TTATT CAA-----------GCAAAACTGTCA-----TTCAA-AAATAA-------AA-------- ------------------------G-AGAAATAAAGACTTTCCCAGACAAAC-AAAAGCT AAGGGA-GTTCATCACCACTAGAC---CTGCCTTAC-AAGAA------------------ --------------------ATGCTAAAGGG----------------------------- -----------------------------------AGTTC-------------TTCAAGT TGA----------------------------------------------------AAATA AAAGGATGCTAAACAGCAACACAATAGCATAAGAAAGTATGAAGCTCA------------ -------------------------------TTGGTAAAGGTA----------------- ------------------------------------AATATAT----------------- --------AGACAAATACAGAATACTGTATTACTGTAA---------------------- ------------------------------------------------------------ ---------------------------------------TAGTGGTGTG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TAAATCACTTTTAATTCTGGTATAAAATTTAAAAGAAAAAATATTTTA AATAAATATA-------------------------------------------------- ---------------------AATAAAAATATGTTAAAAGATACACAATATAAAT----- --------------------AGATGTAAATTGTGACAATAATATCATAAAGTATATGTGT GGGGGGGGGAAGGGTAAATGT--------------------------------------- ------------------------------------------------------------ --GTAGAGTTTTTG---TATGTGATTGAAGTTAAGTTGTTATCAGCTTAA---------- --------AATA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CTGTTATAAC-------------------------TATAA GATATTTTATGTAAGCCCCATG----------------------------GTAACCACAA AAAAAATACC-TATAGAAGTTACACA---------------------------------- ---------------------AAAGAAAAAAA---------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAAAAATA AAAGCATAGCATTACA-AAAAAAAAAACAATAAAACACAAAGGAAGACAGCAAAAGAGGA AAAGAGAGC--------------------------------------------------- ---------------------CAAAAAAACTATA--------------AG---ACAGACA GAAAA------------------------------------------------------- ------------------------------------------------------------ -------------CAA----------TTAACAAA-------------------------- ------------------TGACA-------AGAACAAAT--------------------- ------------------------------------------------------------ --------------------TCATCCCTA--TCAATAATTAC-TTTAAAT-------A-T AAAT--GGACT--AAACTC---CCCAATC----------------AAAAGAC------AT AGAG--TGGCTG----AATG---------GATA------AAAA---AACAAAGACCCAA- ---CTA-------TAT-ACTCTCTA-TAAGAAACTCACTT-TAGAT--TTAAGGACACAC A-TAGGCTGAAAGTGAAGGAA---T------------GGAAA----A-AGATATTCCATG C--------------AAATGG------TAACC---------------------AAAAG-A GAGCAG--GGGT----GGCTATATTTATATC-AGACAAAATAGACTTTAAG-TC------ ----AAAAACTG---TCACAAGAGAC-AAAG-AAGGACAT------TATAT------AAT GATAAA---AGGGTCAATT------CACCAG---GAAG--------AT-ATAACAA-TTA TAA-----------------A----TATATATG---------CACCCAACATCAGAGCAC CTAA--ATA-TATAAAGCAAACATTGACAGAACT--GA----AGGGAGA---------AA TAGACAGCAAT------ACAATAATAGTAGGAGATTTCAATA----------------CT CCACT------TTCAAT-AATAGACAGAACAT---------------------CCAGAC- -----AGAA-------------GATCAATAAGGAAACAGAGGACTTGAAC-AACACTATA GA------CCAAATGG---ACCTAACAGACATATACA--GA----ACATTCCACCCAACA GC---AGCAGAATACACAT------TCTTCTCAAGTG-----CA--CAT-AGAACTTTCT --C----CAGGATAGATCACATGTTAGGTCACAAAACAAG-------------------- -TCTTAACAAATTTAAAAAAA--TTGAAAT----------------CATACCAA------ -GTATCTTTTCT---AACCACAATGGAA-TGAAACTAGAAATCAAT-------------- ----------------------------------------------AGCA--------GA --------------AGG-AAAACTGG---AAAATTCACAA----ATATAAAGAAA--T-T AAACAACATA-CTCTTGAA---CA-ACCATTG--GGTAAAAAAAGA--AAT--C-AAAAA GGAAATT---------------AGAAAATATCTT---AAAAC------------------ ------AAATGAAAACAA-AAA------------CACAAC--ATACCAAAACTTA-TGG- GA-----TGCAGCAAAAGCAGTA-----------------------------CTAAGAGG GAAG--TTTATAGTGATA----AATGC----CTACATTAAAAAAG---AAAAAATATCT- --CAAATA----AACCTAA-CTTTATACCTC---AAGGAAC--TAGAAAAAA------AA AA-----ACAAACTAAGC-------------CCAAAGT--TAGCAGAA-GGAAGGAAATA ACA---AAGATTAGA-------------------GCAGAAATA---AA-T-AAAATAGAA AATAG------AA------------------------------------AAA-CAAATAG AAAAAAAACA-A---------ATA----AACTAA-AAATTTG------TTTTTTTAAAAA AATAAA------------------------------------------------------ --------------------------------CAA-----AATTGACAAACTT---TTAG CTA------GACTAA--CTA------------AAAAA------------------AAAAA A---GAAA-AACAAA-----------------AAATAAA--------TAAAA-----TA- ---------AGA-AATGAAA--GA----------GGAGA---CATTACAACTGATGCC-A CA-GAAATA--AAAAAGAT-CATAAG---------AGACTATT--ATGAA---------- -----------CAA---TTATATACCAACAA---ATTGGATAACCTAG---AAGAAAT-- GAATAAATTCCT----------AGAAACA---------TAC-----AACCTACCA----- -AAACTAAATCA---TGAAGAAATAGAAAATCTGAAC----------------------- AGACC------------TA-TAACTAGTAAGGAGATTGAAT-C---------AGTAAT-- -CAAAAACCTCCC------AACAAAGAAAAG---CCCAGGACC--AGATGG--------- ------------CTTCACT-GGTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAAGAA-AAATTAA--TA-CCAATT----------CTTCTCAA ACTCTT----CC---AAAAAATTGAA------GAGGAG-AG-----------AACACTTC CAAACTCATTTT-----ATGAGGCC-----AGCAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAGC-------CAGAA AAA---------------------GAC---ACCACAAGAAA---AGAAAACTAC------ -------------A-GGCCAATAT---CCC----TGATGAATATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACA-------------------AA--TT--------------TA--ACA----- --------ACACATT---------AAAAAGATTATACA--CCATGAC------------C AAG---TGGGA-TT----------TATTCCT------------TG--GATGCAAGGATGG -G----------------------TC-AAC-----ATTAAA--AAATCAATTAA--TGTG ---ATATACCACAT------TAACAG----AATAAAGGATAAAAAT---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAAGCATTTGACAA---AATTCAACATCCTTT- ---------------CATGA---------T---A--AA-----AACTCTCAAC---AAAC TAGGAATAGAAGGAAATT-----ACCTCAACATAATAAA--------------------- ------GGCCATATAT-GAAAAG--------CCCACAGC-----------TAACAT--CA TACTCAATGGTGA-----AAA-ACTGAAAGC----TTTT---CCT----CT--AAAATCA GGAACA----AGGCAAGG-ATGC--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------TAG-GC------AAGAA---AAAGA --AATAAAAGGCATCCAAATCAGA---AAGGAA------GAAGTAAAA--T--------- ------TTTCTCTG-TT--T---GCAGA------TGACAT------GATCTTATATATA- -GAAAACC--CTAAAGA---CTCCATAA---------A---------------AA--AAC TGTTAAAACT---------AA--TAAATAAATTCAGTAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------CAT--- ACAAAAAT----TAGT-------------------------------------------- -----TTTGTTTT--TA-TATACTAAA---------------AAAAAACAAT-----ATG A------------------AAAAAAAATA-AAA----AAAAAAATCCCATTTACAATAAC AACA------------------AAAAGAATA---------AAA------TACTTAGGAA- --ACTT--------AA--C-TAAGGAGGTG---A---AAGACTTGT---ATAT-TGAAAA CTATAAAACAT------TGATG-AAAGAAATTA-AA------------GAAG-------- ------------ACAC--AAAT--AAA---TGGA---AA--AACAT---------CCT-- --TTTTC------ATTGAATTGGAAGACTT-A---A---TATT--------------G-- TTAAAATG-----------------------------------------TCCAT--ACTA CCC-AA--AGTAATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--C---------------------CCAATG-GC---ATTTTT ------------------------------------------TACAGAAATAG------- ----------------------AAAAAAAAAT------TCTAAAA---TTTATATGGAAA A-------CAAAAAGAACCC---TA--AAAACCAAAACAATCTTGAGAA---AGAA--GA ACA---AAGC--T-------GGA--GGCATCACA---CTTCCTGATTTCAAAAT-----A TATTAC-------------------------AA---AGCTACAGT-AATCAA---AAC-A GTA--------------TGGTACTGG--CA------------T---AAAGACAGACA--- ---TATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAT-- -CCAC----------------ACA-------TATATGG----TCAACT--GATCTTT--- GACAAG--GGTGCCAAGAATACAC--A-------------------ATGGG--GA---AA GG------------ATAGTCTCTT--CAACAAATGG---------------TGTTG---- ------G-GAAAAC--TGG-ATATCCA---------------CATGC-AAAAGA---ATG ---------AAATTGGACCTT---TATCT-----------TACACC--ATA--C---ACA AAAA-TCAACT-CAAAATGG---AT---TAAAGAC---TTAAATATA--AGACCTGAAAC TGT------------------------AAAACTCCTAGAA---------------GAAAA ---CATA-------------------------GAGGAAAAGCTTCATGACATTG--GTC- -----TTGGCAATGATT-----TCTTGGATAT-GACACCA---AAAGCACAGGCAAC--- --AAAAGCA---AA----AAT---AAACAAA-TGGGAC----------TAAATT-AA--- ACTAAAAA-----G------------CTT-TTTCA-------CA--------------AC -AAAGGAAACAAT-------------TAACAGAGTAAAAAG------------------- ------G-------------CAACCT------ATGGAA--T-GGGAG---AAAATATTT- --GCAAACCATATAT--------CT-------GATAAGGGGT--------TA--ATATC- ---CAAAATATATAAG-GA--ACTCCT---ACA------AC--TCAAT------------ ---AGC------AA------AA--AAACA---AAA--AACCTAA-TTA----AAAAAGGG C--AAA---------GGA--CTTGA---AT---AGACATTT------------------- -----CTCCAAAGAA--------GACATAC---AA-ATGGCCAAC--AGGTATATGAAAA GAT-------------CAACATCACTA-ATCATCA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATATCA---------CCTC----ACACCTGTTAGGATGGCTATTATCAAA A--AAAAA-------AAAAAAAATAAAATAACA-AGTG--T------------------- ------TGGT-AAGGATGTG---------------------------------------- ----------------GAGCCCTTGT-TTACTGTTGG--TGGG----------------- ----------AATGA--A-------------AAAT---GGTGC----AGCCGCTATGG-- ------AAAACAATT--TCGAG--GTTTCCTC--AAAAAATTAAAA--ATAGAACTACC- -ATAT---GA--TCCAGCAATCCCA---------------------CTTCTGGG-TATT- --------------TA-TCCAAAAGAA----TTT----AAA---ATCA----G------- --------------AATCTCAAAGAGAGATATTAGC---------ACTCC----TATGTT TATT--GCAACACTATTCACAA-TAGCCAAGATGT--G--GA--AACA--ACCTAA---A TGTCCATTA---ATAGATG-----AATGGATAAAA--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAC----ATACAATAGAATAT-----T--ATTCA GCCTTAA----AA----------------------AAGAAGGAAATTCTGTCATAT---- ------------------------------------------------------------ --------GCTACAACATGGATGAAC-C---TTGAGGACATTATGCTAAGTGA------- ------------------------------------------------AATAAGCCAGTC ACAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAG---------------------------------AAAAATACTTG-------- ---CAT---GATTCCACTTAT----------ATATCT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAT-------AGTCAAA---------------CTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------GAAGCAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GTAGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----GGTGGTT-----------------------------------------------G CCA-------GGGGCTGGGG----------------------GGAGGGGGGAAATGGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GTTGCTGTTCAATGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------TAGAGTTTCAGTTATGCA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGATGAATAAG------------------------------ ---------------TTCTAGAGAT------------CTGCTGTACA------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACATTGT-GCCTATAG------------------------------------------- -------------------------TT-----------------AACAAT---------- --------------ACTGTATTGTACACTTAAAAA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TTTGTTAAG----------AGGGTAGATCTCATGTT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------AA--GTGT TCTTACCACAATAAA--------------------------------------------- ------ >L1MB4 ------------------------------------------------------------ ------------------------------------------------------------ --------TAGTGACATCAGCAAA-----------------ATGGCAGACTAGGAAGCTG CAATTTCTC-AAGACTTGGGAGCACTAAATTTCCCATAGTTCCCCTAAGAAA-------- ----------------------------------CCATCAGAAACTACCAGAACCAACTT TGTAAGAACTCTGGGAAACAATCAACGGATTACACAATTCAGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------AAAAGCTGTAATCAAAATTGGGGG------GGATTCCATAGCATTTTTGGTCGT TGTGGCGTTGCTGCCTGCTCTTTTAGTATATGAT---------G-CTCAGTGTGGCAATA ATTTTAGTCATGAG----------CAGCACA----------------------------- ----------------------------------------------------------AC ACAATCTTGATTTCTCTAATTGATAAGGGAGTGC-----AG---AATAGTCTCTATTAGC GAATAATTGTGTAGGTATGTTCTAACCTGTCT--------------------GGGGGCTA CCTGAAGGACTGATGTAAAGTGAGCATCTCTTTTTGCCTAACTCAATGAGGAAAAGCAGC AGGCAT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TGCTCTCAAAAGCT----ACAAGATA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------ACATAAGAACTG TAGGTGGGTGGGGCCAGAAGATAAAAGTGGAG-------------ACATACAATAGGCCA TCTAATGCCCAAAGGAGAAACTGGAATGAAACTC----------------------TTTT GGAAATTAAGACATT------------CAAAAGTAG---TCAATTAAAATAGGAAATTAA AA---------------------------AAGCAACAACAG------------------- ------------------------------------------------------------ ----AGCCAAAA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------CAAA-- ---------ACATATACACAAAAAAGACCTAAGAAGACCTTAAACTTTCACCTTGGGCTG A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------TCCCTAGACT-------CAGTGCAAGCCTGGCTAACTGTT TAAGGAGG---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GGCATACATGCAGACCTACAGAGCCA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GTCCG TAAAGAGAGAGAGA--------------------------------GGTGGTT------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TTTATTTTCCATGCTTTATTATTGGTTTTGT----TTTAAGTCCTGGGATTCCCGG AAATCTCT---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GTCAGAACA-----------TTAGCTGAATATAAGCT ATAAAAAAAAGAATTTCATGTCCCAACATGAGCAAAAAATAGGTTTTTTAAAAAATAGTT TGGAAAAGTCACTAAACAAACAGACTACTACAGCCTTCAATAATAAA------------- --A-----------AATAAACATACAGACATGCATGCATGCATACAT------------- ----------------------------------------------ACATAAA------- ---------------------------------------AACTTTGAAAAA--------- ---------GAGGA---------------------------------------------- -AAATATGATTTCCAGAATTACAATATAATAATACTTAAATGATTAAGTT---------- ------------------------------------------------------------ -------------------------------CAAAAAAAAA-----TCACAAGGCATA-- -----------------------------------------------CA--------AAG AACA----GGAAAGTA-------------TGGC--TCAT--TCAA---A-GG-------- -------AAC----AAAATAAATT-------------------AA-CAG---AAACCATT CCTGAGG----------------AAG---CCCAGATATTGGAATTACTAGACAA------ ------AGAC------------TTTAAATCAACTGT-CTTAAATATGCTTAAAGAGTT-- --AAAGGAAAACACG--------------------------GACAAAGAACTA-----AA GAAAATC----------------------------------------------------- --AGAAAAA--------------------------------------------------- -TAATATA---------------------------------------------------- ------------------------------------------------------------ -----------------------------TGAACAA------AAT--------------- GAGAATATCAAGG-----------------AATAAGAGAAATTTGTAAAAGG-------- ---AACCAAACAAACAGA----------------TTTG--------------------AG C--AGGC------------------AGAAAAAAT-GAT-TAGCA--AATTTGAAGAC--- -AAGGCAATTAAAA-T-----TATC----------------AAAATAATAGG---GATAC AAAG-----AAAGAAA-AA---------TGA---ACAGTGCCTAAGGAAGATTTGTAAG- ACAAC--------A---TTAAATACTGATCAATATATGC--A-TAATGGG--AATT---- ----------TCAGAAA---AAGAAGTGAGAGAG---AGCATGGCAG---------AAAG AATATTT---GC-----AGAAATAGTGGCC--AAAAGCTTCCCAAGTTG----------- ---------GATGAAAGACAT--GAAT--CTACAAATCC-----AAGAAGCACAACAA-A CTACAAGTA------------TGTTAAT-CTC--------------AAAGACACCAACAG G-------G---------------------AGAAAAATTATAATCAACT-------GTC- AAAAGCAAAAA---CCAAGAC-AAAGAGCCT----------------------------- -------------TGAAAGC--AGCGAGAGA---AGAGAGACTAGT-------------- -----------CAC---ATAAAAAAA-ATTCTCAA--------------TAAGATT--AC CAGCCAATTTC-----TCATCAGAA--ATATTGTGAGTC------CAG-AAGTCAGTG-- -----------GCA-TAGCATATT-------TTAAAG--AGCT-------------GAAA GAAAG-------------A-AAAAACAGTCA--ACCAAGAA--------TTC---TATAT CTG-----------GCAAAACTACCC-----TTCAA-AAATGA-------GG-------- ------------------------T-AGAAATTAAGACATTTCCAGATAAAC-AAAAGCC AAGGGA-GTTCATTACCACTAGAC---CTGCCTTGC-AAGAA------------------ --------------------ATGATAAAGAATG--------------------------- -------------------------------AAAGAACAC--------------TAGACA GTA--------------------------------------ACTTGAAGCCATATGAAGA AATAAAGATCT------------------------------------------------- -------------------------------CTGGTAAAGGTA----------------- ------------------------------------ACTACAT----------------- --------AGGCAAATATAAAAGCTAGTATTATTGTAC---------------------- ------------------------------------------------------------ ------------------------------------TTTTGGTTTGTAA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CTCCACTTTTATTTTCTTTCTATATTATTTAAAAGATAAATGAATAAA ACTATAATTA-------------------------------------------------- -----------------------TAAATCTATGTTATTGGGCACACAATGTATAA----- --------------------AGATGTAATTTGTGACAATAATAAAAACAACATAAGGGGA GGGACGGAGATATATAGGAGC--------------------------------------- ------------------------------------------------------------ ----AGAGTTTTTG---TATGCTATTGAAGTTAAGTTGGTATTATTTAAA---------- --------ACTA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GG-------- --------------------TTGTTATAAG-------------------------TTTAA GATGTTAATT----------------------------------------GTAATCCCCA TGGTAACCAC-TAAAAAATCTGTAAAATATATATA------------------------- ---------------------AAAGGAAATAA---------------------------- ------------------------------------------------------------ --------------------------------------------------AAAGGGAATC AAAATGTTTCACTAAA-AAAAATCAACTAAACACAAAAGAAGGCAGTAATGGAAGAAATG AGGGA------------------------------------------------------- ---------------------CAAAAAAGCTATA--------------AG---ACATACA GAAAA------------------------------------------------------- ------------------------------------------------------------ -------------CAA-------------------------------------------- --------------------ATA-------GCTAAAAGT--------------------- ------------------------------------------------------------ --------------------CATTCCCTA--CCAGTAATTAC-TTTAAAT-------G-T AAAT--GGATT--AAACTC----CAAATC----------------AAAAGAA------AT AGAT--TGGCAG----AAAG---------GATTTT----TAAA---AAACAGGATACAA- ---CTA-------TAC-GCTGTCTA-CAAGAGACTCACTT-TAGAT--CTAAAGACACAA A-TAGGTTGAAAGTGAAAGGA---C------------GGAAA----A-AGATATTCAATG C--------------AAATAG------TAACC---------------------AAAAG-A GAGATG--GAGT----GGCTATACTAATATC-AGACAAAATAGATTTTAGT-TA------ ----AAAAACTA---TTATAAAAGAC-A----AAGGACAT------TACAG------ATT GATAAA---AGGGTCAATT------CACCAA---GAAG--------ATAAGAACAA-TTA TAAAT---------------A----TATACACG---------CACCAAACATCAAAGCTC CAAA--ATA-TATGAAGCAAACACTGACAGAATT--GA----ATGAAGA---------AA GAGACAGTTCT------ACAATAACAGATGGAGACTTCAACA----------------CT CCACT------TTCAAT-AATGGATAGAACAG---------------------CCAGACA GCTAAAGAA-------------GAGCAATAAGGAAACAAAGGACTTGAAC-AACACTATA AA------CCAACTAG---AACTAACAGACATATATA--GA----ACACTCCACCCAACA AC------AGAATACACAT------TTTTCTTAAGTA-----CA--TAT-GGAACATTCT --C----CAGGACAGACCATATGTTAGGCCACAAAACAAG-------------------- -TCTCAATACATTTAAAAAA---CTGAAAT----------------CATACAAACTTTCT TTTATCTTCTCC---AATCACAATGGAA-TAAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------GA --------------AGG-AAAACTGG---AAAATTCACAA----ATATGTGGAAA--T-T AAACAAAACA-CTCTTAAA---CA-ACCATTG--GGTCAAAGAAGA--AAT--C-ACAAG GGAAATT---------------AGAAAATACTTTAAGGAAAC------------------ ------AAATGAAAACGA-AAA------------CAAAAA--GTACCAAAACTTA-TGG- GA-----TGCAGAAAAAGCAGTG-----------------------------CTAAGAGG GAAA--TTTATAGCTGTA----AACGTCA--ATACAATAAAAAAG----ACTAAGATCT- --CA--------AACCCAA-TTTTACACATT---AAGGAAC--TAGAAAAAGTATTAAGA CA-----GCAAACTAAAC-------------CCAAAGT--TAGCAGAA-GGAAGGAAATA ATA---AAGATTAAA-------------------GCAGAAATAGAGAA-C-AGAATAAGA ACAGAG-----AA------------------------------------AAA-------T ACAATGAATA-A---------ACC----AGATGACAAAGTTG------ATTCTTTAAAAA AATCAA------------------------------------------------------ --------------------------------CAGGAGGTAATTGGCAAACTT---TTGG CTA-------CCTAA-----------------AAAAA------------------TATAC A---GAGA-AAACTC-----------------AAAAAAT--------AAAAAGGCCATCT CTACT----AGAGAACTACA--AA----------AACGACTTTCTTAAAACG-------A AA-GAAATAGCAAGAGGACAAATAAA---------AGAGTACT--ATAAA---------- -----------CGA---CTGTATGCCAACAA---ATTGGATTATCTAG---ATGAAAT-- GGATAAATTCCT----------AGAAACA---------CAC-----AACCTACCA----- -AGACTGAATTA---TGAAGAAACAGAAGATCTGAAT----------------------- AGACC------------TA-TAACTAGTAAGGAT-TTGAATTCT--------AGTAAT-- -CAAAAACCTCCC------AACAAAGTAAAG---CCCAGGCC---AGACGG--------- ------------CTTCACA-GGAG--AA-------------------TTCTATATGAATT CTTCTCAAACATTT---AAAGAA-GAATTAA--CA-CCAATC----------TTTCTCAA ACTCTT----CC---AAAAAACTGAA------GAGGAGAGG-----------AACACTTC C-AACTCATTCTATGAGATGAGGCC-AGCCAGCATTGATACCCTG-ATAC---------- ----------------------------------------C--AAAGC-------CAGAC AAA---------------------GGC---ACTACCCTACA---AGAAAACTAT------ -------------A-GAGCAATAT---CCC----TTATGAATATTGAT------------ ------------GCAAAAATCC-TCA-----ACTCACATATGCCATG----CAAAATACT AGC-AAACCA------------------AAGTTT--------------CG--GCA----- --------GCGTAGCAAATAGCAGAAAAGGATTATACA--AGATGACCATACATCATGAC AAG---TGGAA-TT----------TATTCCT------------GG--AATGCAA-GATGG -T----------------------TCAAAC-----ATATGA--AAATCAATTAA--TGTA --CGTACGCCATAT------GAACAG----AATAAAGGAGAAAA-----AAAATGA---- -TCATCTCAACT---GATGC---AGAAAA-GCATCTGACAA---AATTCAACACCCTTT- ---------------CATGA---------T---T--AA-----AAATCTAA-----AAA- --AGAATGGAAGGAAACTTAAACTCACCAACATAATAAA--------------------- ------GGCCATATAT-GAAAAA--------CCCACAAC-----------TAACAT--CA TACTCAATGGTGAAAATGAAAGACTGAAAGCTCACTTTC---CCC----TAAGAAAATCA AGGAAC----AAGCAAAT-ATGC--CCGCTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTCTATTC---AACACAGT ATT---GGAAGCTCTAGCCAGAGCAAT-------CAAG-GC------AAGAA---AAATA --AATAAAAGGCATCCAAATTGGA---AAGGAA------GAAGTGAAAATT--------- ------CATCTCTG-TT--A---GAAGA------TGACAT------GATTGTATATGTA- -GAGAACC--CTAGAGA---TTCCACAA---------A-------------------AAG TGTTAGAGCT-------------AAAATTAACTCAGCAAAA----------ATCAACACA ACAA-------------------------------AATCAA-------------CAT--- GCAAAAAT----CAGC-------------------------------------------- -----TGCGTTTC--TA-CACACTAAC---------------AATGAACAAT-----CTG A------------------AAAGGAAAATTAAG----AAAACAATTCCATTTACAATGGC ATCA------------------AAAAGAATA---------AAA------TACTTAGAAAT AAACTT--------AA--C-CAACAAGGCG---ATAAAAGTCTTGT---ACAC-TGAAAA CTACAAAACAT------CACTG-AAAAATATTA-AG------------GAAG-------- ------------ACAT--AAAT--AAA---TGGA---AA--GACAT---------CCCA- --TGTTC------ATG-GATTGGAAGACTT-A---A---TATT--------------G-- TTAAGCTGGAAGGAAGACTTAATTTAAAAGATGACAATACTACCCGAATACAAT--ACTA CCC-AAAGAGCTATCTACG-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--C---------------------CCAATT-GG---CGTTTT ------------------------------------------TTCAGAAGCG-------- ----------------------AAAAGCCCAT------CCTAAAA---TTCATGTGGAAT C-------TCAAAGGACCCCTAGAA--ATAGCCAAAACAATCTTAAAAAAGCAGAA--GA ACA---AAGT--T-------GGA--GGACTCACA---CTTCCCAATTTCAAACC-----T TACTAC------------------------AAA---AGCTACAAT-AACCAA---AAA-A GTA--------------TGG-ACTAG--AA------------C---AATGACAGACA--- ---TATAGAC--CA---ATGG-AACAGAATTGACAGTCC------AG---AAATAAAC-- -CCAT----------------ACA-------TTTATGG----TCAACT--GATTTTT--- TATATG--AGTGCCAATACCATTC--A-------------------ATGGG--GA---AA GAG-----------AAGTTTTTTT--CAACAAATGG---------------TGCTG---- ------A-GACAAC--TGG-ATATCCA---------------CCTTA-AAAAAG---AAG ---------AAGTTGGATAC----TATCT-----------CATACC--ATATTT---ACA AAAAGTTAACATAAAAATGG---AT---CAGAGAC---CTAAATTTA--AGAGTGAAAAT ---------------------------AAAATTCTTAGAATTAAA----------GAACA AAACGTAAGAACTAAAAATGTAGGCTACGAAAA-AAACAATCTTCATGACCTTG--GGT- -----TTGGCAATGGTT-----CCTTAAATAT--ATACCA---AAAGCACAGGCAAC--- --AAAAGAA---AAC---AATAAAAGATACA-TTGGGC----------TTTATAAAA--- ATTAAAAA------------------CTT-TTGTG-------CT--------------TC -AAAGGACACCAT-------------CAAGGACATGAAATG------------------- ------A-------------CAACCC------ACAGAA--T-GGGAG---AAAATATTT- --ACAAATCATATAT--------CT-------GGTAAGGGTT--------TA--ATATC- ---CAGAATATATAAA-GA--ACTACT---ACA------AC--TCAAC------------ ---AAC------A-------AA--AAACA--------AACACCAATTCA---AA-----G C--AAA---------AGA--CTTGG----------------------------------- -------CCATAGAA--------GATATAC---AA-ATGGCCAA---AAGCACATGAAAA GAT----------GCTCAACATCACTA-GCCACTG------------------------- -----GGGA-AATGCAAA-----------------TC-AAAATCACA-------AT---- ----GA---GATACCA---------CTTC----ACACTCG-------AGCTA-------- -----AAA-------------------ATAAAA-AGTG--T------------------- ------TGGTAGAGGATGTG----------GAGAA------------------------- ------------ATTGTAACCCTTGT-ACATTGCTGG--TGGG----------------- ----------AATAT--A-------------AAAT---GGTGC----AGCTGCTGTGG-- ------AAAACAGTA--TGGCA--G-TTCCTC--AAAAAATTAAAC--ATAGAATTACC- -ATAT---TA--TCCAGGAATTCCA---------------------CTCCTAGG-TATA- --------------TA-CTCAAAAGAACTGATAG----CAGAGACTCA----A------- ------------------------ACAGGTATTTGT---------ACACC----AACATT CATA--GCAGCATTATTCACAA-CAGCCAGAAGGT--G--GC--AACA--ATCCAA---A TGTCCATCA---ACAGATGTTCCAAATGGATATAA--AACA------------------- -----TGGTA-------------------------------------------------- ------------------------TATAC----ATACAATGGAATAT-----T--ATTCA GCCTTAA----AA----------------------AGGAATGAAATTCTTATACCT---- ------------------------------------------------------------ --------GCTAGAACATGAATGAAC-C---TTGAAAACATTATGCTAAGTAG------- ------------------------------------------------AATAAGCCAGAC ACAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAGG---------------------------------ACGAATAT-TG-------- ---TAT---GATTCCACTTAT----------ACAAGATACCC------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AGAAT-------AGGCAAA---------------TTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------GAGACAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAA--------ATAGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGAGGTT-----------------------------------------------A CCA-------GGGGCTGGCG------------------------GGAGAAGGAATGGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GTTACTGTTTAATGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAGAGTTTCTGTTTGGGA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------TGATGAAAAAG------------------------------ ---------------TTTTGGAAATGGATAGTGGTGATGGTTGCACA------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACATTGTAGAATATAC------------------------------------------- -------------------------TT-----------------AATGCC---------- --------------ACTGAACTGTACACTTAAAAAGGGTTTGGTAAAAATTTTATGTTAT GTACATTTTACCACAATTTTGAAAAAAATATTAGAAGAAAATTTTCCTAATTTGATAAAT GACATCTACATAAAAAAACCTACAGCAAACATCATACTTAATGGTAAAAATATTGAAAGC TTTCTCCTCGATACCAGAATCGAAATAAGGATGCCTATTATCACCACTTCCATTCAATAT TATGCTGGAAGTCCTTGCCATTGCAATAAAAGCAAGAAAAAAGATATAAGTATTGGAAAG GAAGATATAAAACTGTTATTATTTATAGAAAACATGATCGTGTATGTTAAAAAATTAAAA AATTCAATAGATAAACTATCAGAATTAATAAGTAAATTTAACAAAGGTTGTATAATATAT AGAAAAAATCAATTATACTTCTATATGACAAATAAATAATTAGAAATGAAAAAATTAAAT ATCACTTACAATAGTATCAAAAAACATAAAACACATAGAAATAAATCTAATTTTAAAAGT GTAAGACTGCTACACAGACGACTAAAAGCATTCTTGAACGAAATTTATTAAGACCTAGAT AAATGGAGGAGTATATCTTGTTCATGGATTGGAAAACTCAATATTGTAAAGATGTCAATT TTCCTCAAATTGACCTACATATTTTTGATGCAGTCTCAATCAAAATCTCAGCAGGGTTTT TGTGGAATTTCAAAAGCCGATTCTAAAATTTATATGGAAATGCAAAAAGCCAAAAATAAA ACAAGAGTCTTGAAGAAGAACAAAACTAGAAGGATTTACACTACCAGATATCAAGACTAC ATATATAAAGCTATAGTAATTAAGCTATAAAGCTTGTATTGGTACAAGGACAGTCAAATA CCAATAGAATTGCATATACATATATGTACACCAAAAGACACACACACAAATGTTCATAAC AGCCTCTTTCGTAATAAGCCAAAAATGGAAGCAACCCAATCGTCCATCAACAGTAGAATG GGTAAATTGTGGTATATTCACACCATGGAATACTATGCAGTAATGAAAATGAGATACCTA GAATAGGCAAATTCATAGAGACAGAAAGTAGATTAGAGGTTACCAGAGGCAGGGGGGAGG GGGGAATGGGAAGTTATTGTTTAATGGGTACAGAGTTTCTGTTGGGGGTAATAAAATGTT CTGGAAATAGATAGTGGTGATGGTTGTACAACACTGTGAATGTACTTAATGCCA--CTGA ATTGTACACTTAAAAATGGTTAAAATGGCAAATTTTATTTTACGTATGTTTTCCCTCAAT AAA--- >L1MB2 ------------------------------------------------------------ ------------------------------------------------------------ ---------AGTAACCTCAGCAAG-----------------ATGGTGAACTAAGAAGCTC CAGGCTCTC---------------------------ATTTTCTCACAGGGAT-------- ---------------------------------------ACCAAGTTAACAAATAAATAC AGAGAATAACAACTTTACAAAAACTCTAAAGAGACCAGTTAAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------AAATTGTTAAACCCAGTTCAATATA TAACCAAGAAGAGATTATAGTAAA---------------------AGAAGTAGGATAATG TGTAGATTTTCGTA---------------------------------------------- ------------------------------------------------------------ TAACCACCCCTTCCCTACCTCATGGCACACAAAAATATTGA---GATACTACAGCAACCT TCCATTTTCTAG------------------------------------------------ -CAGGGGACAGGGAAGGGAAAAAAAATCTTGTTCCCCTAATTTCCCT------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TGTCAGGGGCTCC---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CCAAAGGACTGGTTTCTGTCTCGCCTGGCTCAGAGCACTGA TGGGACTGTGGGTC---------------------------------------------- ---------------------------------------ATTTTGAAAATCGATAGCTCA GG---------------------GGCTTGTGGCGGCAGCAG------------------- ------------------------------------------------------------ ----ATAGG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------CCATATAACTACACAGGCATATACAAGGAAAAAAGAGAGTTAAAA------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------ACTCTTGCCC-------ATGAAAAGGCACAAAACCTATTT GATAGGAATATAAA---------------------------------------------- ------------------------------------------------------------ ----------------------------------CCCAAAGCCCAGGCAGATCCTCTACC GATAT-AAGATACCTCCTGCATCTCCAGCTAGGCTGATTGA------------------- ------------------------------------------------------------ --------------------------------------------TGAAAGTCTTCCCCTG TAAAAAGCCAGTCTTTAA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AGACTGGGAGAGGTGGTTTTTTTTAACTGTCCAATTTT AACAAAAAGAATTA---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------CAACGAAAA-----------AGAAAAAAAAGGAAGA- ------------------------------------------------------------ ------------------------------------------------------------ --A-----------ACAGACCATTAAAAAAGCAAAAAAAAAGCA---------------- ----------------------------------------------ACAGAAACT----- ---------------------------------------GACCCTAAAGAA--------- ---------AAGCAGATCTAAGACCTACT------------------------------- -AGACAAAGACTTTAAAATAACTGTCTTAAAGATGCTCAATGAGC--------------- ------------------------------------------------------------ -------------------------------TAAAGGAAAACACAAACAATAAACAGAAT CA--------------------------------------GAAAAATGATGC-----ATG AACAAAATGGGAATAT-------------CAAT---------------AAAG-------- -------------------------------------------ATATAA---AAATAAAA AAAAAAT----------------AAA---AAGAAATTTTGGAGCTGAAAAATACAATAAC TAAAATGAAA----------AATTCACTAGAGGGATTCAATAGCAGACTTGATCAGGC-- --AGAAGAAAAAACT--------------------------TGAAGACAGTTCATTTAAA ATAATAT-------------------------------------CAGGCCGGAGAAACAG AAAGAAAAA--------------------------------------------------- -AAATGAA----------GAAAAGTGAAGAAAGCCTAAGGGACTTGTGGGACACCATCAA GCAGACCAATATATGCATT------------------------ATGGGAGTTTCAGAAGG ----------AAGA---------------GAGAGAG------AAGAGGGCAAAATAATA- AAGC----TTAAA---------AATAC---AGTAAGTAAAGTGAATAATTCACTAAAA-- ---ATGTTCAATAGCAGA----------------CTAG--------------------AT C--AGGC------------------AGAAGAAAAAAATGAACAG--AACTTGAAGAC--- -----------AGA-T-----CATCAAGTCAG---------AGGAACAACAACAACAAAA AAGA---ATGAAAAA--AG---------TGA---AGACAGCCTAA--GGGATTTGTAAG- ACAAC--------A---TTAAAGT--GATCAATATATGC--A-TAATGGG--AATT---- ----------TCAGAAA---AAGAAGTGAGAGAG---AGCATAGCAG---------AAAG CATATTT---GA-----AGAAATAATGGCC--GAAAACTTCCCAAAATT----------- ---------GATGAAAGAAAT--GGAT--ATACAAATCC-----AAGAAGCTCAACAA-A CTCCAACTA------------TGATAAA-TTC--------------AAAGACACCCACAC G-------A---------------------AGATATATTATAATCAAACT------TTC- -AAAACAAAAA---CCAAG---AGAAAGCCT----------------------------- -------------TGAAAGCAAAGCAAGACATACTAAA---------------------- -----------CAC-----AAAAAAAAAAATTTCA--------------TTAAGTTTACA AAGCAGATTTC-----TAGACAGAA--ACTTTG-GAGGC------CAG-AAGGAAGTG-- -----------GGA---TGATA-T-------TTAAAG--AACTAG-----------AAAA AAAAA---------------AAAAACACCCA--ACCAATTA--------T-----TGTAT CTG-----------GAAAAACTATAC-----TTCACAAAATGA-------GG-------- ------------------------G-AGAAATTAGGACTTTCCCAGATAAAC-AAAAGCT GAGGGA-GTTCATTATCATTAGAC---CTGCCTTGCAAAGAA------------------ --------------------ACACAAAAGGA----------------------------- ------------------AAATTAAACAATAAAAGAATGC--------------TAGACA GTA----------------------------------------------------ACATG AAAGCATATGAAGATATAAATATCT----------------------------------- -------------------------------CTGTTAAAGGT------------------ ------------------------------------AAAATAT----------------- --------AAACATTTACAAAAACTAGTATCTTTAATT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TTGT AATGTTGGTGCATAAATCAATTTTAATTCTGGTATAGTATTTAAAAGAAAAACATATAAA AATAACTATA-------------------------------------------------- -------------------------AATCTATATTAATGGATACACAATATAAAA----- --------------------AGATGTAATTTGTTACAATAATATAAAGTAGGGGGGGGGG GGATGTAAAGGAGT---------------------------------------------- ------------------------------------------------------------ ----AGAGTTTTTG---TATGCAATTGAAATTAAGTTGTTATCAGTTTAA---------- --------AATA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------TTGTTATAAC-------------------------TTTAA GATGTTTTATGTAATCCCCATG----------------------------GTAACCACAG AGAAAATACC-TATAGAAGATACACAAAAGAAAATGA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GAAAGGAATC AAAGCATGTCACTACAAAAAAATCAATGAAAAACAAAGAAAGGAAAAAAGGAAGAAAAGA GGAAAAAAAAAGCCATAAGACATA------------------------------------ ---------------------AAAAACACAAATAACAATACACAAAATAA---ACAATCA ACTAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------AATGACA-------ATATTATGT--------------------- ------------------------------------------------------------ --------------------CATTCCCTA--TCAGTAATTAC-TTTAAAT-------G-T AAAT--GAATT--AAACAC---TCCA-------------------AAAAGAC------AT AGAA--TGGCTG----AATG---------GTT-------AAAA---AAAAGCGATTATA- ---CTA--------------------TAAAGGACTT-----TAGAT--ATAAAAATACAC A-TAAGCTGAAAGTGAAAGGA----------------AAAAA----AAAGAAATTACATG C--------------AAAAAG------TAAAA---------------------AAAAG-A AAGCAG--GGTT----TGCTATACTAATATC----------------------------- ------------------------------------------------------------ -------------------------AAATAA----------------------------- -------------------------TATATATG---------CACCAAACATCAGAGC-- ----------TATAAAGCAAACATTGACAGAATT--GA----AGGGAGA---------AA TAGACAATACT------ACAATAATAGTAGGAGACTTCAATA----------------CC CCACT------TTAAAT-ATTGAATAGAACAA---------------------CCAGAC- -----AGAA-------------GATAAATAAGGAAAAAAAGGATTTGAAC-AACACTATA GA------CCAATTGG---ACCTAACAGACATATACA--GA----ACACTCCACCCAACA AC---AGCAGAATACACAT------TCTTCTCAAGTG-----CA--CAT-GAAACATTCT --C----CAAGATAAAACAAATTTTAAGCCACAAAAAAAG-------------------- -TCTTAACAAATTTAAAAAAA--TTGAAAT----------------AATAAAAA------ -GAATTTTTTCT---TATAACAATGGAA-TAAAACTAGAAATCAAT-------------- ----------------------------------------------AGCA--------AA --------------AGG-AAAATTGG---AAAATATAAAA----ATTAAAAAAAATAA-T ATACAAAAAA--ACCTAAA---TA-------------TAAAAAAGA--AAT--C-ACAAG GGAAATT---------------AGAAAATATCTT---GAGAC------------------ ------AAATGAAAATGA-AAA------------CACAAC--ATACCAAAAAATA-TGAT AA-----TGAAATAAAAGAAGTA-----------------------------CTAAGAGG AAAG--TTTATAAATATA----AATGT----TTATATTAAAAAAA---------GATCT- --CAAATCAAT-AACCTAA-CTTTACACCTC---AAGGAAC--TAAAAAAAG------AA GA-----ACAAACTAAAC-------------CCAAAGT--TAGCAGAA-GGAAGGAAATA ATA---AAGATTAGA-------------------GCAGAAATA---AA-T-AAAATAGAA ACTA-------------------------------------------------------T AAAAAAAATT-A---------AAA----AAAAAA-AAAATTG------GTTTTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATTGACAAACCC---TTAG CTA------GATTAA--CAA------------AGAAA------------------AAAA- ---------AGACTC-----------------AAATAAC--------TAAAA-----TC- ---------AGA-AATGAAA--GA----------GGAGA---CATTACAACTGATGCC-A CA-GAAATA--AAAAGGAT-TATAAG---------AGAATACT--ATAAA---------- -----------CAA---TTGTATGCCAACAA---ATTGGATAACCTAG---AAGAAAT-- GGATAAATTCCT----------AGAAACA---------TAC-----AACCTACCA----- -AGACTGAATCA---TGAAGAAATAAAAAATCTGAAC----------------------- AGACC------------TA-TAACTAGTAAGGAGATTGAAT-C---------AATAAT-- -CAAAAATCTCCC------AAAAAAGAAAAG---CCCAGGACC--AGATGG--------- ------------CTTCACT-GGAG--AA-------------------TTCTA-------- ----CCAAACATTT---AAAGAA-GAATTAA--CA-CCAATC----------CTTCTCAA ACTCTT----CC---AAAAAATTAAA------GAAAAG-GA-----------AACACTTC CAAACTCATTCT-----ATGAGGCC-----AGTAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAGC-------CAGAC AAA---------------------GAC---ACTACAAAAAA---AGAAAACTAC------ -------------A-GACCAATAT---CCC----TGATGAATATTGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACTC------------------AA----------------------ACA----- --------GCACATT---------AAAAGGATTATACA--CCATGAC------------C AAG---TGGGA-TT----------TATTCCT------------GG--AATGCAAGGATGG -T----------------------TC-AAC-----ATATAA--AAATCAATCAA--TGTA ---ATACACCACAT------TAACAG----AATGAAGGACAAAAAC---CACATGA---- -TCATCTCAATT---GATGC---AGAAAAAGCATTTGACAA---AATTCAACAACCTTT- --------------TCTTGA---------T---A--AA-----AACACTCAAC---AAAC TAGAAATAGAAGAAAACT------ACTTAACAAAATAAA--------------------- ------AGCCATATAT-GAAAAG--------CCCACAGC-----------TAACAT--CA TACTCAATGGTGA-----AAA-ACTGAAAGC----TTTT---TCT----TT--AAGATCA GGAACA----AGGCAAGG-ATGC--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTCTATTC---AACATAGT ATT---GGAAGTTCTAGCCAGAGCAAT--------TAG-AA------AAGAA---AAAAA --AATAAAAGACATCCAAATTGGA---AAGGAA------GAAGTAAAA--T--------- ------TATCTCTG-TT--C---ACAGA------TGACAT------GATCTTATATGTA- -GAAAACC--CTAAAGA---TTCCACAA---------A---------------AA--AAC TGTTAGAACT---------AA--TAAAT------AGTAAAAAGGTA-----CAAAATAA- --AA-------------------------------ACTCAA------------------A AAAAAAAT----TGGT-------------------------------------------- -----TGTTTTTC--TA-----TTAAC---------------TATGAACAAT-----TCG A------------------AAAAGAAATTAAAA----AAAAAAATTCCAATTTCAATAAG CACA------------------AAAAAAAAA---------AAA------TACTTAGGAAT AAATTT--------AA--C-CAAAAAGGTG---A---AAGACTTGT---ACAC-TGAAAA CTACAAAACAT------TGCTG-AAAAAAATAA-AA------------GAAG-------- ------------ACACACAAAT--AAA---TGGA---AA--GATAT---------CCCG- --TGTTT------ATG-GATTGAAAGACTT-----AATTTTTT----------------- TTAAATTT-----------------------------------------CCAAT--ACTA CCC-AA--AGCAATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--C---------------------CCAATGAGT---TTTTTT ------------------------------------------GGAAGAAATGG------- ----------------------AAAAATTAAT------CCTAAAA---TTCATATGAAAT C-------TCAAGGGACCCT---GA--ATAGCAAAAAAAATATTAAAAA---AAAA--AA AAA---AAAATGT-------GGA--GGACTCACA---CTTCCTGATTTCAAAAC-----A TATTAC-------------------------AA---AGCTACAGT-AATCAA---AAA-A GTG--------------TGGTACTGG--CA------------T---AAAGACAGACA--- ---TATAGAC--CA---ATGG-AATAGAATAGAGAGCCC------AG---AAATAAAC-- -CCTC----------------ACA-------TATATGG----TCAAAT--GATTTTT--- AACAAG--GGTGCCAAGACCACACAAA-------------------TTGGG--AA---AA AA------------AAAACTCTTT--AAAAAAAAGG----------------GTTG---- ------G-GAAAAACCTGG-ATATCCA---------------TATGC-AAAAGA---ATG ---------AAGTTGGACCCT---TACTT-----------TACACC--ATA--T---ACA AAAA-TTAACT-CAAAATGG---AT---TAAAGAC---CTAAACATA--AGACCTAAAAC TAT------------------------AAAACTCCTAGAA---------------GAAAA ---CATA-------------------------GAGGAAAACCTTCATGACATTG--GAT- -----TTGGCAATGATT-----TCTTGGATAT-GACAACA---AAAGCACAGGCAAC--- --AAAAACA---AA----AAT---AGACAAA-TGGGAC----------TACATCAAA--- CTTAAAAA------------------CTT-CTGTG-------CA--------------TC -AAAGGAAACAAT-------------CAACAGAGTGAAAAG------------------- ------G-------------CAACCT------ACAGAA--T-GGGAG---AAAATATTT- --GCAAATCATATAT--------CT-------GATAAGGGGT--------TA--ATATC- ---CAGAATATATAAA-GA--ACTCCT---ACA------AC--TCAAC------------ ---AAC--------------AAAAAAACA---AACCCAACAT---TAAA---AAAATGGG C--AAA---------GGA--CTTGA---AT---AGACATTT------------------- -----CTCCAAAGAA--------GATATAC---AA-ATGGCCAAC--AAGCATATGAAAA GAT----------GTTCAACATCACTA-ATCATTA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATATCA---------CCTC----ACATCCATTAGGATGTCTACTAT---A AAAAAAAA-------AAACAAA-----ATAACA-AGTG--T------------------- ------TGGT-GAGAATGTG----------GAGAA------------------------- ------------ATTGGAACCCTTGT-GCACTGTTGG--TGGG----------------- ----------AATGG--A-------------AAAT---GGTGC----AACCGCTATGA-- ------AAAACATTA--TGAGG--GTTCTCTC--AAAAAATTAAAA--ATAGAATTACC- -ATAT---GA--TCCAGCAATCCCA---------------------CTTCTGGG-TATA- --------------TA-TCCAAAAGAA-----------ATTGAAAGCA----G------- --------------GATTTTGA--AGAGATATTTGC---------ACACC----CATGTT CATT--GCAGCAATATCCAAAA----------GAT--G--GA--AGCAACACACAA---A TGTCCATTG---ACAGATG-----AATGGATAAAC--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAC----ATACAATAGAATAT-----T--ATTCA GCCTTAA----AA----------------------AAAAAGGAAATTTTGTCACAT---- ------------------------------------------------------------ --------GCTACAACATGGATGAAC-C---TTGAGGACATTATGCTAAGTGA------- ------------------------------------------------AATAAGCCAGTC ACAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAG---------------------------------ACAAATAC-TA------CT ATCTAAAGTAGTCAAATTCAT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------A-- ------------------------------------------------------------ ------------------------------------------------------------ ------GAAACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAA--------GTAGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----GGTGGTT-----------------------------------------------G CCA-------GGGGCTGGGG-------------------GGAGGGGGAAAAGGGGAGT-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------TGTTTGTTTAATGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------TAGATTTTCAGTTTTGCA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGATGAAAAAG------------------------------ ---------------TTCTGGAGATCTGTTGCACA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACAATGT-GAATATAT------------------------------------------- -------------------------TT-----------------AACACT---------- --------------ACTGAACTGTACACTTAAAAATGGTTAAGATGGT------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAATTTTAT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TTTATG--TGTT TTTTACCATAATAAAAA------------------------------------------- ------ >L1MB3 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AG AGAAATT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------CTG- AAGC----TTAAA---------GGTAT---AATAACTAAAATGAAAAATCTACTAGAG-- ---AGATTCAAAGGCAGA----------------TTTG--------------------AG C--AGGT------------------AGAAGAAAG-AAT-CAGAG--TACTTGAAGAT--- -AGGACAATGAAAA-T-----TATTAAGCCTG---------AGAAACAGAAA---GAAAA AAGA---TTAAAGAAA-AG---------TGA---ACAGAGCCTAA--GGAACATGTGGG- ACACC--------A---TCAAGTA--GACCAACATACAT--A-TTGTTGG--AGTC---- ----------CCAGAAA---GGGAAAAAAAAAAA---AAAGGGACAA---------AGAG AATATTT---GA-----AAAAATAATGGCT--GAAAACTTCCCAAATTT----------- ---------GATGAAAGACAT--GAAT--ATAAACATCC-----AAGAAGCTCAACAA-A CTCCAAGTA------------AGATGAA-CTC--------------AAAGAGACCCACAC C-------G---------------------AGACACATTATAATCAAACT------GTC- AAAAGACAAAG-----------AGAGAATTT----------------------------- -------------TGAAAGC--AACGAGAGA-----AGTGACTTAT-------------- -----------CAT---ATACAAGGG-ATCCTCAA--------------TAAGATT--AT CAGCAGATTTC-----TCATCAGAA--ACTTTG-GAGGC------CAG-AAGGCAGTGGA CAGAAGGCAGTGGGCTAATATA-T-------TCAAAG--TGAT-------------AAAA AAAAAACGAACAAAAAAAAAAAACTG--TCA--ACCAAGAA--------TTC---TATAT CTG-----------GCAAAACTGTCC-----TTCAA-AAGTGA-------GG-------- ------------------------G-AGAAATTAAGACATTCCCAGATAAAC-AAAAGCT GAGGGA-GTTTATTACCACTAGAC---CTGCCCTAC-AAGAA------------------ --------------------ATGCTAAAGGG----------------------------- -----------------------------------AGTCC--------------TGCATA TTA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGAATCT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------AGAAATA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TCAGCGATTAC-TTTAAATTAATTACTTT AAAT--CGACTAAACCTAC---CACAATC----------------AAAAGGC------AT AGAT--TGGCAG----AATG---------GATTTTTAT-AAAA---AAATAGCATCCAA- ---CTA-------TAT-GCTGTCTA-CAAGAGACTCAGTTTTAGAT--CTAAAGACACAA A-TAGTTTGAAAGTGAAAGGA---T------------GAAAA----A-AGATATGCCATG A--------------AAATAGTATTATTAACC---------------------AAAAG-A GAGCAG--GGGT----GGCTATACGGATATC-ACACAAAACAGACTTTAAG-TC------ ----AAAAAAGC---TTACAAGAGAC-AAAA-AAGGACAT------TTTAT------ATT ATTAAA---AGATACAGTA------CAGCAA---GAAGTACCAACAAGAATAACAA-TAA TAA-----------------A----CATATATA---------CACCAAATATCAGAGCAT CAAA--ATA-TACGAAGCAAACATTGACAGAATT--GA----ATGGAGA---------AA CAGATAGCTCT------ACAAGAACAGTAGGAGACATTAGCA----------------CT CCGCT------TTCAAT-AATGGATAGAACAAGGAGACATAAGATCCCCACATCCAGAC- -----AAAG-------------AATCAATAAGGAAATAAAGAACTTGAAC-AACACTATA AA------CCAATTAG---ACCTAACAGACATATACA--GA----ATACTCCACCCAACA AC---AGCAGAACACACAT------TTTTCTCAAGTG-----CA--CAT-AAAACATTCT --C----TAGGATAGACCATATGTTAGGCCACAAAACAAG-------------------- -TCTTAATAGATTTTTAAAAACAGAGAAATGTATATATTTAGAAAACATAAAAA------ -GTATCCTTTTT---AACAAAGAATGGA-TAAAACTAGAAATCAGT-------------- ----------------------------------------------AACA--------AA --------------AGG-ATAACTGG---AAAATTCGAAA----AT-TATGAAAAATG-T AAACAATACA-CTCCTAAC---CA-ACCAATGATGGGTAAAAGAAA--AAT--C-ACAAA GGAAATT---------------AGAAAATATTTT---GACATATGTAAATATATATCTTG TGACAAAAATAAAAATAA-AAA------------CACAAC--TTACCAAAACTTA-CGG- GA-----CGGAGTGAAAGCAGTG-----------------------------CTAAGAGA AAAA--TTTATAGCTATA----AACAC----ATACATAAAAAAAG---AAGAAAGATCT- --CAAATCAAC-AACCTAA-TTTTACACCTT---AAGGAAC--TAAAAAAAG------AA GA-----ACAAACTAAAC-------------TCAAAGC--TAGCAGAA-GAAAGGAAATA ATA---AATATTAGA-------------------ACAGAAATA---AG-T-GAAATAGAA AATAG------AA------------------------------------AAA-CAA---T AGAAAAAATA-A---------ACG----AAACCA-AAAGTTT------GTTTTTTGAAAA GATCAA------------------------------------------------------ --------------------------------CAA-----AATTGACAAACCT---TTAG CTA------GATTGA--CTA------------AGAAA------------------AAA-- ----GAAA-AGACAA-----------------AAATTAC--------AAAAA-----TC- ---------AGA-AATGAAAGAGA----------GGGGA--TCATAGTAACTAATTTT-A TA-GAAATA--AAAAGGAT-AATAAA---------AGAGTACT--ATGAA---------- -----------CGA---TTATGTGCCAACAA---ATTGGATAATCTAG---ATGAAAT-- GGACAAATTTCT----------AGAAACA---------CAA-----AACCTACCA----- -AGACTGAATCA---TAAAGAAATAGAAAATCTGAAT----------------------- AGACCTATAATTT-------TAACTAGTAAGGAGATTGAAT-C---------AGTAAT-- -CAAAATACTCTC------AAAAAAGAAAGG---CCACGGGCT--GGAGTC--------- ------------TTTCATT-AGTG--AA-------------------ATCTA-------- ----CCG----------AAAAAA-GAACAGA--AATCCAATC----------TTCCCAAA TCTTTT----CA---AAAAAATAGAA------GAGGAT-AG-----------AACACTTC CTACTCAATTCA-----TTGAGGCC-----CACTT---TTTCCTT-ATAC---------- ----------------------------------------C--AAAAC-------CAGAC AAA---------------------GAC---ACTACAAGAAA---AAAAAATAAT------ -------------A-GACCAACAT---CTC----TTATGAACATTGAT------------ ------------GTAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAAGTG------------------AA--TT--------------CT--AAA----- --------GCATATT---------AAAAGAATTATACA--CCATGAC------------C AAG---TGAGA-TT----------TATTCCT------------GG--AATGCAAGGATGG -T----------------------TC-AAC-----ATACAA--AAATCAATCAA--TGTA ---ATAGTCCACAT------TAACAG----AATGAAGGAGAAAAACCCACATATGA---- -TCATCTCAATT---GATGC---AGAAAAAGCATTTGACAA---AATTTAAACACCTTT- ---------------TAAGATTAAAAAAGC---A--AA-----AAAACTCAAC---AAAC TAGGAATAGAAGGAAACT-----ACCTCAACTTAATAAA--------------------- ------GGCCATGTAT-AAAAAA--------CCCACAGC-----------AAACAT--CA TACTCAAAGATGA-----AAAAACTAAAAGT----TTTT----------CTCCAAAATTA AAAACA----AGACAAAG-ATGC--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TTACCACTTCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------TAG-GCAAATAAAAGAAAATAAAGA --AATTAAAAGCATCAAAAAAGGA---AAGGAA------GAAGTAAAA--T--------- ------TATCTCTG-TT--C---ACAGA------TGATAT------AATCTTATATGTA- -GAAAACC--CTAAAGATTTTTCCATAA-------------------------AA--ATC CACAAAAA-----------AA--TAAACAATTATAATAAAG--TTAAAAAAAAAAAAACC CTGAAAATTGTTAGAATTGATAAATATATTCAGCAAATCAA-------------CAC--- AAAAAAAT----TAAT-------------------------------------------- -----TGCATTTC--TA-TACACTAAA---------------AATGAACAAT-----TTA A------------------AAATGAAATT-AAG----AAAACAATTCCATTTACAATAGC AACA------------------AAAAGAATA---------AAA------TACTTAGGAAT AAACTT--------AA--C-CAAGGAGGTG---A---AAGACATGT---ACAA-TGAAAA CTACAAAACAT------TGCTG-AAAGAAATAA-AA------------GAAGACGGAAAC ACACACACACACACAA--AAAT--AAA---CAGA---AA--GCAAA---------TTCA- --TGTAA------ATA-AATGGGAAGACAT-ATTAA---TATT----------------- --AACGTG-----------------------------------------TCCAT--ATGT CACCAA--AATGATCTATA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--C---------------------CCAATG-CCAATGTTTTT ------------------------------------------TGTAGAAATAA------- ----------------------AAAAACCCAT------CCTAAAA---TTCATATGGAAT C-------TCAAGGGACCCC---AA--ATAGCCAAAACAATCTTGAAAA---AGAA--GA ACA---AAGC--T-------GGA--GGACTCACA---CTTCCTGATTTCAAAAC-----T TACTAC-------------------------AA---AGCTACAGT-AATCAA---AAT-A GTG--------------TGGTACAGG--CA------------T---AAAGACAGACA--- ---TACAGAC--CA---ATGG-AATAGAATAGAGAGTCC------AG---AAATAAAC-- -CCTC----------------GCA-------TATATGG----TCAAAT--GATTTTT--- GACAAG--GGTGCCAAGACCATTC--A-------------------ATGGG--GA---AA GG------------ACAGTCTTTT--CAACAAATGG---------------TGCTG---- ------G-GAAAAACTGGACATATCCA---------------CGTGC-AAAAGA---ATG ---------AAGATGGACTCA---TACCT-----------CATAAC--ATA--C---ACA AAAA-TAAACT-CAAAATGG---AT---CAAAGAC---CTAAATGTA--AGAGCTAAAAC TAT------------------------AAAACTCTTAGAA---------------GAAAA ---CATA------G------------------G-GCAAAAGCTTCATGACATTG--GAT- -----TTGACAATGATT-----TCTTGGATAT-GACACCA---AAGGCACAGGAAAC--- --AAAAGAA---AA----AAT---AGAAAAA-TTGGAC----------TTCATTAAA--A ATTTAAAA------------------TTT-CTGTG-------CA--------------TC --AAAAAAACAAT-------------AAAAAGAGTTAAAAG------------------- ------G-------------CAACCC------ACAGAA--T-GGGAG---AAAATATTT- --GCAAATCATATAT--------CT-------GATAAGGGAT--------TA--ATATC- ---CAGAATATATAGA-GA--ACTCCT---AAA------AC--TCAAC------------ ---AAC------AGACAATCAA--AAACA---AAC--AACCCAA-TTCA---AAAATGGG C--AAA---------GGA--CTTGA---AT---AGACATTT------------------- -----CTCCAAAGAA--------GATATAC---AA-ATGGCCAAT--AAGCACATGAAAA GAT----------GCTCAACATCACTA-ATCATTA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAACTACA-------AT---- ----GA---GATACCA---------CCTC----ACACCCATTAGGATGGCTACTAT---T AAAAAAAAAATAGAAACAGAAA-----ATAACA-AGTG--T------------------- ------TGGC-GAGGATGTG----------GAGAA------------------------- ------------ATTGGAACCCTTGT-GCACTGTTGG--TGGG----------------- ----------AATGT--A-------------AAAT---GGTAC----AGCCGCTATGG-- ------AAAACAGTA--CGGCG--A-TTCCCC--AAAAAATTAAAA--ATAGAATTACC- -ATAT---GA--TCCAGCAATTCCA---------------------CTTCTGGG-TATA- --------------TA-CCCAAAAGAA------------TTGAAAGCA----G------- --------------GGTCTCAA--AGAGATATTTGT---------ACACC----CATGTT CATA--GCAGCATTATTCACAA-TAGCTAAAACGT--G--GA--AGCA--ACCCAA---G TGTCCATCA---ACAGATG-----AATGGATAAGC--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAC----ATACAATGGAATAT-----T--ATTCA GCCTTAA----AA----------------------AGGAAGGAAATTCTGACACAT---- ------------------------------------------------------------ --------GCTACAACATGGATGAAC-C---TTGAGGACATTATGCTAAGTGA------- ------------------------------------------------AATAAGCCAGTC ACAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAGG---------------------------------ACAAATAC-TG-------- ---TAT---GATTCCACTTAT-ACTGAGGTCAAATAAAGGTACTAGAACTACATATATTA ACATTGATGAATCACAAAACCTAACGTTGAATGAAAACAGAAAGTCACAGG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAA-------AAATGAA---------------TCCATTTTTATG-- ------------------------------------------------------------ ---------------------------------------------------TAGGGTAAA ACTGGGCAAATAA----------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------TAAACAATA CATTGTTTAGAGATACATTCGTAAATGATAAACTTTAAGGAAAAACAAAGGAGT------ ------------------------------------------------------------ ------------------------------------------------------------ -----GATTAAC-----------------------------------------------A CCGAATTCTGGAGAGCGGTAACTTTTGATAGGTAGGGAGGGGGAAGTGATTGGGGTGG-- -------------------------------------------------GG--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------GCGCACAGAGGACTTCTCTCTTTTA--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AGCTATGAGGTAGG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------TCTTGAGTTTTCATCTTATGATTATTTTTAAA------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACTCTGT-GTGTGTGT------------------------------------------- ------------------------------------------------------------ --------------------TTGTGTGTGCG----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TGTGTTACG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------AA--TAAT ACATTCCCCAATAAAAAGAAT--------------------------------------- ------ >L1MA10 ------------------------------------------------------------ ------------------------------------------------------------ ---ACATCAAGAGACATCAGGAAA-----------------TTGGCAGAATTGGAGGCTC TAGCCTTCA----------------------------TACTCCCAGTATTGG-------- ----------------------------------CAACCATCCACAGACATGAATATCTT TATGGAAGCC-------ACAGAATCTAATTAAGAGGTTCCAAC----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------ACCTCAATGGGACCAAAAATTCAA------GAATAGATTCATTGAAGAAATTAA AAAAACTAATTTCACTTAACCTTTGTCACCTCTA---------T-CCTAAGATAGCACAG GCTCAGTGCTAAGA----------GAGGTTC----------------------------- ------------------------------------------------------CCTCAG CCCACAATTTCTCCCACATTAAATGAAAGAATCA-----AA---GTAAACACCTGGCTTC CCAGCCTTGTTGAATACTTCT-------------------------------CAGGATGC CCACTTCTCAATGTTTCAGGTAGGTCTTGTGGGACCCAAAACACTAAGAGGAACAGCAT- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GGCTAAATCATCT----GGGGACAACTAA GAGCAGTGAAAAGGGGAAAAAATACACAGCAACTGCCACACAGTTCTCAACATCCAGTTG CCAATACTCCCAACGT-------------------------------------------- ------------------------------------------ACTCATGGACTTCATCAA GAGGTCCATCTGTAAACCCCACAGGATGTCCT-------------GCCTGAAGATCCCTT GACCAGCCAATCTGCAGCC----------------------------------------- ----------------------------------AG---ATAATCTGCCCCAAACCTCTA GTGAGTTGCACCATGGGCATCCCATGTATGAACCATATGAA------------------- ------------------------------------------------------------ ----CTCCTGAA------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------GACAACACA-- ---------TAGATTTCAACAGCAGGTGTATATTGTTGCAACCAGCTCAACTTTGCTGGT TTAGAAGAAGGCTCACA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------ACCTTGAAAA-------CTTCAGAGCACTGCCATAATGAA AATAAACAAGAAGTTATCAGCACTAGTC-------------------------------- ------------------------------------------------------------ -------------------------------------------------TTGGCTTTGTA AGACT-AAGTGAAGGCACACAATCCTAACTTTGCCCCTAAAAGAGGTCAAAAAAAAAT-- ------------------------------------------------------------ --------------------------------------------GGAATGGGTGCATCAA TAGT------AAATGTATGAGAGACCCATAGAATGTCTAGCTAGGCTCACTGGTGAAGGT C----------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------TTTCTCTCCCAAAGCCAGTTA GTAAAGACGGAAAT--------------------------------ATAAGATGCCTGGG TG------------ACTGCTTCTTCAAATGCAAAGACAGTAATGTAAAGATTCAAGGAAC ACAAAGAATCAATGAAATATGACACCACCAAAGGGAC-----------------AAAATA AAGCTATAGAAATCCACATAAATGAGATATAGAAATTGAACTGCCAGAAAAAGAATTCAT CTTAAAGAAACTCAATAAACCAAGAAAGATCTCAA----AATAACACAGAGACTCACAA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AAAAACATA-----------CTAGAGAAAAAAATGAA CAAAATGAGAAGTTCAACAAAGAGATAAAAACCATAAAAAAGACCAAAATGGAATTCTTG GTGTGAAAAATATAATGTCTGAACTAAAAAATTAAAAAGATTTAAAA------------- --A-----------AAAAATTAATTGAAGGTGAGAAAAAAAAAATTCA------------ ----------------------------------------------ATGAAATAGAAAAT GGATTAACAAACTTAAATAGAAAACTTTAGAAATAAT--CCAGTTAAAAGA--------- ---------AAAAAAAGGAA---------------------------------------- -AAAAATCAGATAGTAAAAAAAGACTTGTAGGATTATGGGACACCATCAAGCAAACCAAT ATATGCATTATGGGAGT-----------------------------------------CT CAGAAGG------------------------AGAAGAGAAA-----AAGAAGAAGAAAGC TTATATAAATAAACAAAGACAGTCTGCAGAGCTTCTA---GGAAAACAA--------AGA ATCA----AAAAAACA-------------CAAT--ACCA--CCAA---A-AG-------- -------AAC----AAAATAAAGC-------------------TC-CAG---AGACTGAT CTTAAAA----------------AAA---TGGATACTTATGAAATGCCATCAAG------ ------TGAA------------CAAAGAGTAATTATCTTTAATAAAACTCAGTGAGCC-- --ACAAGAGAAAAAA--------------------------ATGATAGAA--------AA CTAAATT---------------------------------------------TCATATTA G-GAGAACA--------------------------------------------------- -TTGCATAAGTGAAGTTAGAATTTCAACAAAAAG-------------------------- -------------------------------------------ATACACACCTTTAAAAA ----------GAAC---------------CAAACAT------AAA---------TTCTG- GAAAA---TGAAA---------AGTAA---AATTGATATACTGAAGAGTTCATCAGAG-- ---TCTCTTAATAGCAGA----------------ATTG--------------------GC C--AAGC------------------AGAAGGAAG-AAT-TAGTG--AGCTTGAAGAC--- -AGGCTATCTGAAAAT------ACACAGTCAA---------AGAGGATTAAA---GACAA AAGTAGGATGAAAAAG-AA---------TGA---AGCATGCCTGC--AGGCTCTAGAAA- ATAGC--------CTCATGAGGAA----TAATCATCTGA--G-TTATCGG-----C---- ----------CTTAAGGAGGAGGTAGGGAAAGAG---ATAGGGGTAT---------AAAG TTTATTCAGGTAATTTTAAAAATTATTACA--GAAAACTTCCCAAATCT----------- ---------TGGAAGAGATAT--GAAC--ATCCAGATCC-----AGGAAGCTCAAAAA-A TCCCAAACA------------AGTTTAA-CCC--------------AAAGAAGTTCTCCC C-------A---------------------AGGCACATTATAATTAAACT------ATC- AAAAGTCAAAG---AAAAAG--AAAGAA-------------------------------- -------------TGAAAAA--AGAAAAAGA---AAAAAAACTCAT-------------- -----------CAC---ATATAAAGG-AGAAACCA--------------TAAGACT--GT CAGCGGATTTT-----TTAGCAGAA--ACGTTA-CAGGC------CAG-GAGAGAGTG-- -----------GGA-TGATATA-T-------TCAAAG--TGCT-------------GAAA GAAAA-------------A-AGAATG--TCA--GCCAAGAA--------TAC---TATAC CCA-----------TAAAAGATGTCC-----TTCAGTGAATAA-------AG-------- ------------------------GAAGAAAGAAAGTCTTTCCTAGACAAAC-AAAAGCT GAGGGA-TTTCATCATCACTAGAC---CTGCCTTAC-AAGAA------------------ --------------------ATGCTAAAGAG----------------------------- -----------------------------------AGTTC--------------TTCAAG TAG----------------------------------------------------AAATA AAACTCA----------------------------------------------------- -------------------------------CTGGTAAAGGTA----------------- ------------------------------------AGTATAT----------------- --------AGACAAATTCAGAATGCTCTAATACTGTAA---------------------- ------------------------------------------------------------ ---------------------------------------TGGTGGTGTG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TAAATCACTTTTAATCCTAGTATATAAGTCAAAAGACAAAAGTATTGA GAATATCTAT-------------------------------------------------- ----------------ATCCACACAAAAATTTGTTAATAAATACACAACATAAAA----- --------------------AGAAGTAAACTATGATATCAGTAACATAAAGTGAGGGAGG AAAACATAAAATGT---------------------------------------------- ------------------------------------------------------------ ----TGAGTTTGTG---TATGTGATTGAAGTTAA---GTTATCAGCTTAA---------- --------AATA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CTGTTATAAC-------------------------TATGA GAGGTTCAATGTAAACTTCATA----------------------------GTAACTACAA AGAAAAAACC-TATAGCAGATACATAAA-------------------------------- ---------------------AAAGATAAAGA---------------------------- ------------------------------------------------------------ --------------------------------------------------GAAAAGAATC AAAGCATATCACTACA-AAAAAAATCAAAAAAAATCATCACAAAGGAAGACAGCAAGAGA GGAAGAGAGGAA------------------------------------------------ ---------------------CAAAAGAACTACA--------------AA---AGAGATA GAAAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------CAATTAA----------------------- ------------------------------------------------------------ --------------------CAAAACCTA--TCAATAATTAC-AATAAAT-------A-T AAAT--GAATT--AAATTC---TCCAATC----------------AAAAGAC------AT AGAG--TGGCTA----AATT---------GATT------AAAA---AAACAAGATCCAA- ---CTA-------TAT-GCTGTCTA-TAAGAGACTCACTT-TAGCT--TTAAGGACACAC A-TAGGCTGAAAGTAAAGAAA---T------------GGAAA----A-AGATATTCCATG C--------------AAATGG------TAACC---------------------AAAAG-A GAGCAG--GAGT----GGCTATACTTATATT-AGATAAAATAGATTTTAAG-TA------ ----AAAAACTG---TCACAAAAGAC-AAAA-AGGGTCAT------TATAT------AAT GATAAA---AGGGTCAATT------CATCAA---GAAG--------AT-ATAACAA-TTG TAA-----------------A----TATATATG---------CACCCAACATCAGAGCAC CTAA--ATA-TATAAAGCAAATATTAACAGAACT--GA----AGGGAGA---------AA TAGACAGCAAT------ACAATAATAGTAGGGGACTTCAATA----------------CC CCACT------TTCAAT-AATGGATAGATCAT---------------------CCAGAC- -----AGAA-------------AATCAATAAGAACAT--TGGAATTGAAC-AACACTATA AA------CCAAATGG---ACCTAACAGATATATACA--GA----ACATTTCACCCAAAA GC---ACCAGAATATACAT------TCTTCTCAAGTA-----CA--CAT-GGAACATTCT --C----CAGGATAGATCACATGGTAGGCCACAAAACAAG-------------------- -TCTTAACAAATTTAAAAAGA--TTGAAAT----------------CATATCAA------ -GTATTTTTTCT---GACCACAATGAAA-TGAAACTAGAAATCAAT-------------- ----------------------------------------------AATA--------GA --------------AGG-AAATTGGG---AAAATTCACAA----ATACGTGGAAA--T-T AAACAACACA-TTCTTGAA---CA-ACAATTG--GGTCAAAAAAGA--AAT--A-AAAAA AGAAATT---------------AAAAAATATCTT---GAAAC------------------ ------AAATAAAAATAT-AAC------------AAAAAT--AAACAAAAATTTTTGGGT GA-----TA-AAAAAAAGCAGTA-----------------------------TTAAGAGG AAAG--TTTATAGTGAA-----AACAT----TTTTTTTAAAAAAA---AAGAAAGATCT- --CAAATAAAC-AACCTAA-CTTTACACCTC---AAGGAAC--TAGAAAAAG------AA AA-----ACAAACTAAGC-------------CCAAAGT--TAGCAGAA-GGAAGAAAATA ATA---AAAATTAGA-------------------GCAGAAATA---AA-T-GAAATAGAG AATAG------AA------------------------------------AAA-CAA---T AGAAAAAA-------------ATA----AAAAAA-ATAGTTT------GTTTTTTGAAAA GATAAA------------------------------------------------------ --------------------------------AAA-----AATTGACAAACCT---TTAG CTA------GACTAA-----------------GAAAA------------------AAGAG A---AAAA-AAACAC-----------------AAATAAA--------TAAAA-----TC- ---------AGA-AATAAAA--AA----------GGAGA---CATTACAACTGATACC-A CA-GAAATA--AAAAGGAT-CATAAG---------AGACTATT--ATGAA---------- -----------CAA---TTATATGCCAACAA---ATTGGATAACCTAG---AAGAAAT-- GGATAAATTCCT----------AGAAACA---------TAC-----AACCTACCA----- -AGACTGAATCA---TGAAGAAATAGAAAATCTGAAC----------------------- AGACC------------AA-TAACAAATAAAGAGATTGAAT-C---------AATAAT-- -CAAAAACCTCCC------AACAAAGAAAAG---CCCAGGACC--AGATGG--------- ------------CTTCACT-GCTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAAGAA-GAATTAA--TA-CCAATT----------CTTCTCAA ACTCTT----CC---AAAAAACTGAA------GAGGAG-GA-----------AACACTTC CAAACTCATTTT-----ATGAGGCC-----AGCAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAGC-------CAAA- AAA---------------------AAC---ACACCAAAAAA----AAAAAATAC------ -------------A-GGTCAATAT---ATC----TAATAAACATGGAT------------ ------------GCAAAATTTT-TCA--------------------A----AAAAATACT AGC-AAACTG------------------AATATT--------------CA--ACA----- --------GCACATT---------AAAAGGATCATACA--CCATGAT------------C AAG---TGGGA-TT----------TATCCCT------------GG--GATGCAAGGATGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--TGTG ---ATACACCACAT------TAACAG----AATGAAGAATAAAAAT---CACATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTTGACAA---AATTCAACATTCTTT- ---------------CATGA---------T---A--AA-----AACTCTTAAC---AAAT TAGGTATAGAAGGAAAAT-----ACCTCAACATAATAAA--------------------- ------GGCCATATAT-GAAAAG--------CCCACAGC-----------TAACAT--CA TACTCAATGGTGA-----AAA-ACTGAAAGC----TTTT---CCT----CT--AAGATCA GGAACA----AGACAAAG-ATGC--CCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TTACCACTTCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------TAG-GC------AAGAA---AAAGA --AATAAAAGGCATTCAAATTAGA---AAGGAA------GAAGTAAAA--T--------- ------TATCTCTG-TT--T---GCAGA------TGACAT------GATCTTATATATA- -GAAAACC--CTAAAGA---CTCCATCA---------A---------------AA--AAC TTTTAGAACT--------------AAATAAATTCAGTAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------CAT--- ACAAAAAT----CAGT-------------------------------------------- -----TGTGTTTC--TA-TATACAAA----------------AATAAACTAT-----CTA A------------------AAAAAAAATTAAAA----AAAATAATCCCATTTACAATAGC ATCA------------------AAAAGAATA---------AAA------TACTTAGGAAT AAATTT--------AA--C-CAAGGAGGTG---A---AAGATCTAT---ACAC-TGAAAA CTATAAAACAT------TGATG-AAAGAAATTA-AA------------GAAG-------- ------------ACAC--AAAT--AAA---TGGA---AA--GATAT---------CTCA- --TGTTC------ATG-GATTGGAAGAATT-A---A---TATT--------------G-- TTAAAATG-----------------------------------------TACAC--AATA CCA-AA-----AGTCTATTC------------------AA---TTCAATTCA---ATC-- ------T-CTAATAAAAT--T---------------------CCAAAG-AC----TTTTT ------------------------------------------AAAAAAAATAA------- ----------------------AAAAAAAAAC--------TAAAA---TTCATATGGAAC C-------ACAAAACCTTCT----A--ATAGCCAAAGCAATCTTAAGTA---AAAA--AA ACA---AAGC--T-------GGA--GGCATCATA---CTTCCTGATTTCAAAAT-----A TATTAC-------------------------AA---AGCTATAGT-AATCAA---AAC-A GTA--------------TGGTACTGG--CA------------T---AAAAACAGACA--- ---TATAGAC--CA---ATGG-AACAGAATAGAGAGCCC------AG---AAATAAAC-- -CCAC----------------ACA-------TATATAG----TCAAT---AATTTTG--- AACAAG--GGTGCCAAAATTAAAC----------------------AAGGG--GA---AA AG------------ATAGTCTCTT--CAATAAATTG---------------TGTTG---- ------G-GAAAAC--TGG-ATATCCA---------------CATGC-AAAAGA---ATG ---------AAATTGGACCCT---TATCT-----------TAAAAC--ATA--T---ACA AAAA-TCAACT-CAAAATGG---AT---TAAAGAC---TTAAATGTA--AGACCTGAAAC CAT------------------------AAAACTCCTAGAA---------------GAAAA ---CATA---------------------------GGGAAAACTCCTTGACATTG--ACC- -----TTGGCAATGATT-----TTTTGGATAT-GACACCA---AAAGCACAGGCAAA--- --AAAAGCA---AA----AAT---AAAAAAATTGGGAT----------TAAATC--A--- ACTAAAAA-----A------------GTT-CTGCA-------CA--------------AC -AAAAGAAACAAT-------------CAACAAAAAAAAAAG------------------- ------G--------------AACCT------AAAAAA--TAGGGAG---AAAATATTT- --GCAAATCATATAT--------CT-------GATAAGGGGT--------TA--ATATC- ---CAAAATATATAAG-GA--ACTCCT---ACA------AC--TCAAT------------ ---AGA------AA------AA--AAACA---AAA----------TTA----AAAATGGG CAAAAAAACTACAATAGA--CCTGA---AT---AGACATTT------------------- -----CTCCAAAGAA--------GACATAC---AA-ATGGCCAAC--AGGTATATGAAAA GAT----------GCTCAACATCACTA-ATCATCA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATATCA---------CCTC----ACACCTGTTAGGATGGCTATTAT---- A--AAAAA-------AAAAAAA-----AAAACA-AGTG--T------------------- ------TGGT-GAGGATGTG----------GAGAA------------------------- ------------AAGGGAACCCTTGT-ACACTGTTGG--TGGG----------------- ----------AATGT--A-------------AATT---GGTAC----AGCCATTATGG-- ------AAAAAAGGA--TAGGG--GTTTTCTT--AAAAAATTAAAA--ATAAAACTATCA TATAT---GA-ATCCAGCAATCCCA---------------------TTTCTGAG-TATA- --------------TA-TCCAAAAGAA-----TT----GAA---ATCA----G------- --------------GATCTCAA--AAAGATATCTGC---------ACTCC----CATGTT CATT--GCAGCATTATTCACAA-TAGCCAAGATAT--G--GA--AACA--ACCTAA---A TGTCCATCA---ATGGATG-----AATGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAC----ACACAATGGAATAT-----T--ATTCA GCCTTAA----AA----------------------AAGAAAGAAATCCTGCCATTT---- ------------------------------------------------------------ --------GTGACAACATGGATGAAC-C---TGGAGAACATTATGCTAAGTGA------- ------------------------------------------------AATAAGCCAGAC ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAG---------------------------------AAAAATAC-TA-------- ---CAT---GATCTCACTTAT----------ATGTGGAAATCT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAT-------AGTCAAA---------------CTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------GAAGCAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GTAGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----GGTGGTT-----------------------------------------------G CCA-------GGGGCTGGGG-------------------GGGGGGGGAAATGGGGAGG-- -------------------------------------------------TG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TT--------------------------------- ---------------------------------GTTCAATGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAAAGTTTCAGTTATGCA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGATGAATAAG------------------------------ ---------------TTCTGGAGAT------------CTGCTGTACA------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACATAGT-GCCTATAG------------------------------------------- -------------------------TT-----------------AACAAT---------- --------------ACTGTATTGTACTTTAAAAATTTGCTAAGAGGGTAGATCTTATGTT AAGTGTTCTTACCACAAAAAAAACAAATTATAAATACATA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAAACCAATATAATAAGGAGGGGCAGGAGGAAACTT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------TTGGAGGTGATGTATATGTT TATGGCCTTGATTATGGTGATGGTTTCATGGGTATATACTTATCTCCAAACTCA--TCAA GTTGTCTACATTAAATATGTACAGTTTTTGTATGTCAATCATACCTCAATAAAGCTGTTT AAAAAA >L1MA4A ------------------------------------------------------------ ------------------------------------------------------------ ---------------GGCTTCAAG-----------------ATGGCTGACTAGAGGCATC TGGTACTCG---------------------------CCTCCTCCACAAAG---------- ---------------------------------------AAGAACCAAAATAGTGA---- ----------GTAGATAATCACACTTCGAATAGATCATCTAAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------AGAGAACACTGGAATTCAACAGAG------AAGTGACAGGA------------- ---------------AACACCTAAGGCAAGGAAG---------GAGAGGGAAGCGAGGCA GCCTGCTTGGCTGG---------------------------------------------- -----------------------------------------------GATTGGCTGGGAG CCTGGAGAGGCTCCCCAATGTGGGGAAAGGGTAA-----GT---GAGAGACCCCCAGTGG TCCACATTCCCAC---------------------------------------TGTGGACT CCTGCAATCCTAGCCATGGGAGAGCCCCTCGACCCTCACAGGCCCTGAGACTAAC----- ---------------------------------------------ATAGGGAGCTGCCTG GAGACTGTACGATGGCATTGCTCCAGAGAGGGAGCTCATGCTGGGTCCCACAC------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ACCCCCCGAGTCC----TAAGCAGCTACA GCATGGCGCCATTTTGAGAGCCCAGCCCCCACCAGACTGCATCCTGCCCTGGGGCCCAAC AGCCCCTGCATCTCCA-------------------------------------------- ------------CATCCCTGGAGCCCCACTGACATTCCCTGCCCACAGCCACCGCCGCTG CTGGCTGCTGCTGCCAGGGCTGAAGCGCGAGCC------------ATTGGCAGTGACCCC ACCCCCCCCGGAGGCGGGGCTGCTGTGCATTTTCATGTGCCCTGAGGACAGGCTCCCCTA CCTGCAGCTGCCACC------------GCTGTGGGCTGCCACGGCCGGGGCGAAAGCAGG GG----------------TGCCAGGGGCTACCCCGGCCCAA------------------- ------------------------------------------------------------ ----CCCAATGCCGGCTGCTGCTGGGCCAAAGTGTGAGCGAAGCGCATGCTCCCCAGCCA CCTGCCTATGG------------------------------------------------- ----------------------------------------CTGCTGCCACTGAAAGCA-- ---------ACCCCACCCTCCCCAGTAGCAGGGCTGCAGTGCAGCCACTGCTGCCCCCAC CTGAGCATTCCGCCAGGG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GCCTGGGGAT-------CACCCTGCCCCTGCCTACCACAG CCAGTGCCTGCATGCACCACTGGGGGGC-------------------------------- ------------------------------------------------------------ -----------------------------------------CTGAGGACAGGCCTGCCCG GCCCG-GCTCCACCCCCCCAGTGCCTGAGCATGCCGTCTGGGGGCCTGGGGATCGCCCAG CCCAGTCCACCACCATTGGCACC------------------------------------- --------------------------------------------TGAGCACTCCTCCCAG G---------GGCCTGAGGTTGGGCCCACCCAACCTGCTGCACCACAGCTGGCA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CCCACCTGCATGTGCCACCTG TGGGCCTGGGGACTGGCCTGCCCAGCCCATTGCAGCCACCGCCAACACCAGCGTGGACTG CTTGGGAGCCAGAGGGTTGTCCTGCCACTGCTACTGCCATTGCCCATGCCATGCCTGCTG CCCAGGGGCCCGAGAACCTGCCCACCTGCCTGGCCCACTGCTGCCACTGCTGGCACCTGA GCAAGCCACCTGGAGGCCCAAG--AATCGGCCTGCCTGGACCCACTAACACCGGTGCCAG CGTACACCACCCTGGGGCCCAAGGACAGGCATGCT----CAGCCCACCACTGCCACCACT GGGGCCCAAGGACTGGCCCACCTGGCATCCCCGTCCCC---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AGCAAAACTTCACCACAGCCTCCACTAACAACTGCAC CCTAAGCCACTGAGGAAATCACAGACACCACTGATGCTGTTTACAGCCAAAGAAATCATA CAGAGACTACACTACTGC------------------------------------------ --A-----------TGCACCCAGAATCAAAGCCAAAGTGCCCTAC--------------- ----------------------------------------------CCAACCAACACCAT AGATAC---------------------------------ATCTTCAGGAAA--------- ---------AAGTCTTCCCCTAT------------------------------------- -GAAAGCAAATTCAAAAAATTGGAAGAAGTGACTGTTACACCAGACATAAAT-------- ------------------------------------------------------------ -------------------------------ACCGCAGATA-----TCAAAATAAGGACA CAG-------------------------------------GAAACACGA--------AAA AGCA----AGGAAATA-------------TGAC--ACCT--CCAA---A-GG-------- -------AAC----ACAATAATTC-------------------TC-CAG---CAACAGAT CCCAATC----------------AAA---AAGAAATTTATAAAATCCCAGAAAA------ ------AGAA------------TTCAAAATAATGAT-ATTAAAGAAGCTCAGTGAGAT-- --ACAAGAGAAATCA--------------------------AAAAAAAAAATA-----AA AAAAAAT---------------------------------------------AAA----- --AAAAAAA--------------------------------------------------- -CAATTCA----------GGATATGAATGAGAAATTTACCAAAGAG-------------- -------------------------------------------ATAGATATCATAAAAAA ----------GAAC---------------CAAACAG------AAA---------TTCTG- GAAC----TGAAG---------AATTC---ATTGAATGAAATACAAAATACATTTGAA-- ---AGCTTCAACAATAGA----------------CTAG--------------------AT C--AAGC------------------AGAAGAAAG-AAT-TTCAG--AACTTGAAGAC--- -AGGTCTTTTGAAA-T-----AACCCAGTCAG---------ACAAAAATAAA---GAAAA AAAA---AAAAAAAAA-AAAAAAAAGAATAA---ACAAAGCCTAT--GTGACATATGGGA ACACC--------A---TAAAGTA--ACCAAATATTTAAATA-TTTTGGG--TGTC---- ----------CCAGAAG---GCGAAGAGAAAACA---AAAGGGTTAG---------AAAA CCTATTT---AA-----TAAAATAATAGAT--GAAAACTTCCCAAGTCT----------- ---------AGCAAGAGATTT--AGAC--ATCCAGATAC-----AGGAAGCTCAGAGA-T CCCCAAATA------------GATACAA-TTC--------------AAAAAGGTCTTCTC C-------A---------------------TGGCACATTATAGTCAAACT------GTC- AAAAGTCAAAG---ACAAAG--AGAGAATTC----------------------------- -------------TAAAAAC--AGCAAGAGA---AAAGCATCTAGT-------------- -----------CAC---CTATAAAGG-AACCCCCA--------------TCAGACT--AA CAGCAGATTTC-----TCAGCAGAA--ACCTTA-CAGGC------CAG-GAGAGAATG-- -----------GGA-TGATATA-T-------TCAAAG--TGCT-------------GAAA GAAAA---------------AAACTG--CCA--CCCAAGGA--------TAC---TATAT CCA-----------GCAAAATTATCC-----TTCAT-AAATGA-------AG-------- ------------------------G-AGAAATAAAGTCTTTCCCAGACAAGC-AAAAGCT GAGGGA-ATTCATCACCACTAGAC---TAGCCCTAC-AAGAA------------------ --------------------ATGCTTAAGGG----------------------------- -----------------------------------AGTCC--------------TAAACC TGG----------------------------------------------------AAATA AAACCC------------------------------------------------------ -------------------------------ACTGGTAGAGCA----------------- ------------------------------------AACACAC----------------- ------------AAATAAGGAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GAAAGGACTC AAATGTTACCACTACA-GAAAACCACCAAACCACAATGATAAACAATAAGAGAGAAAGAA AGGAA------------------------------------------------------- ---------------------CAAAGGATATACA--------------AA---ACAACCA GAAAT------------------------------------------------------- ------------------------------------------------------------ -------------CAATTAATAAA------------------------------------ ------------------TGACA-------GGAATAAAA--------------------- ------------------------------------------------------------ --------------------CCTCACATA--TCAATAATAAC-CTTGAAT-------G-T AAAT--GGATT--AAATTT---TCCACTT----------------AAAAGAT------AT AGAC--TGGTTG----AATG---------GAT-------TAA----AAAAATTATCCAA- ---ATA-------TATGGTTGCTTA-AAAGAAACTCACTT-TACCT--GTAAAGACACAT A-TAGACTGAAAGTAAAGGGA---T------------GGAAA----A-AGATATTCCATG C--------------AAATGG------AAACC---------------------AAAAG-C AAGCAG--GAGT----AGCTATACTTATATC-AGATAAAACAGACTTTAAG-TC------ ----AAAAACAG---TAAAAAAAGAC-AAAG-AAGGTCAT------TATAT------AAT GATAAA---GGGATCAATC------CAGCAA---GAGG--------AT-ATAACAA-TTC TAA-----------------A----TATATATG---------CACCCAACACTGGAGCAC CCAG--ATT-CATAAAGCAAATATTACTAGATCT--AA----AGAGAGA---------GA TAGACTCCAAT------ACAATAATAGTGGGGGACTTCAACA----------------CC CCACT------CTCAGC-ATTAGACAGATCAT---------------------CTAGAC- -----AGAA-------------AATCAACAAAGAAACATTGGATTTAAAC-TGGACTTTA GA------CCAAATGG---ACCTAACAGACATTTACA--GA----ACATTTTATCCAACA AC---TGCAGAATACACAT------TCTTCTCATCAG-----CA--CAT-GGAACATTCT --C----CAGGATAGACCATATGTTAGGCCACAAAACAAG-------------------- -TCTCAACAAATTTTTAAAAA--TTAAAAT----------------CATATCAA------ -GTATCTTCTCA---GACCACAATGGAA-TAAAACTAGAAATCAAT-------------- ----------------------------------------------ACCA--------AG --------------AGG-AACTTTGG---AAACTATACAA----ATACATGGAAA--T-T AAACAACATG-CTCCTGAA---TG-ACCATTG--GGTCAATGAAGA--AAT--T-AAGAT GGAAATC---------------AAAAAATTTTTT---GAAAC------------------ ------AAATGAAAATGA-AAA------------CAAAAC--ATACAAAAACCTG-TGG- GA-----TACAGCAAAAGCAGTG-----------------------------CTAAGAGG GAAG--TTTATAGCAATA----AATAC----CTACATCAAAAAAG---TAGAAAGATTT- --CAAATAAAC-AATCTAA-CAATGCACCTC---AAGGAAC--TAGAAAAGC------AA GA-----ACAAACCAAAC-------------CCAAAAT--TAGCAGAA-GAAAAGAAATA ATA---AAGATCAGA-------------------GCAGAACTA---AA-T-AAAATAGAG ACTAA------AA------------------------------------AAA-AAA---T AAAAAGGATC-A---------ATA----AAATAA-AAAGTTG------GTTTTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATTGATAAACCA---CTAG CTA------GACTAA--CCA------------AGAAA------------------AAAAA A---GAGA-AGACCC-----------------AAATAAA--------CAAAA-----TC- ---------AGA-AATGAAA--AA----------GGAGA---CATTACAACTGATACC-A CA-GAAATA--CAAAAGAT-CATCAG---------AGACTATT--ATGAA---------- -----------CAA---CTATATGCTAACAA---ACTGGAAAACCTAG---AGGAAAT-- GGATAAATTCCT----------GGAAACA---------TAC-----AACCTACCA----- -AGATTGAATCA---GGAAGAAATAGAAAACCTGAAC----------------------- AGACC------------AA-TAATGAGTAGTAAGATTGAAT-C---------AGTAAT-- -AAAAAGTCTCCC------AACAAAGAAAAG---CCCAGGACT--GGATGG--------- ------------ATTCACT-GCCA--AA-------------------TTCTA-------- ----CCAAACATAT---AAAGAA-GAACTAA--TA-CCAATT----------CTTCTCAA ATTATT----CA---AAAAAATTGAA------GAGGAG-GG-----------AATTCTCC CTAACTCATTCT-----ATGAGGCC-----AGCAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGAC AAG---------------------GAC---ACAACAAAAAA---AGAAAACTAC------ -------------A-GGCCAATAT---CCC----TGATGAACATAGAT------------ ------------ACAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACCA------------------AA--TT--------------CA--ACA----- --------GCACATC---------AAAAAGATAATACA--CCATGAT------------C AAG---TGGGA-TT----------TATACCA------------GG--GATGCAAGGATGG -T----------------------TC-AAC-----ATATAC--AAATCAATAAA--TGTG ---ATACATCACAT------CAACAG----AATGAAGGACAAAAAC---CATATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTTGATAA---AATTCAACATCCCTT- ---------------CATGA---------T---A--AA-----AACTCTCAAC---AAAC TAGGCATAGAAGGAACAT-----ACCTCAAAATAATAAA--------------------- ------GGCCATATAT-GACAAA--------CCCACAGC-----------TAACAT--CA TACTGAATGGGGA-----AAA-GTTGAAAGC----CTTT---CCT----CT--AAGAACT GGAACA----AGACAAGG-ATGC--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAAGGCATCCAAATTGGA---AAAGAG------GAAGTCAAA--T--------- ------TGTCCCTC-TT--T---GCAGA------TGACAT------GATCTTATATCTA- -GAAAAAC--CTAAAGA---CTCCACCA---------A---------------AA--AAC TCTTAGATCT---------GA--TAAATAAATTCAGTAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------CAT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCATTTC--TA-TACACCAAT---------------AATGAACTAG-----CTG A------------------AAAAGAAATC-AAG----AAGGCAATCCCATTTACAATAGC TACA------------------AAAAAAATA---------AAA------TACCTAGGAAT AAATTT--------AA--C-CAAGGAGGTG---A---AAGATCTCT---ACAA-GGAAAA CTACAAAACAC------TGATG-AAAGAAATTG-AA------------GAGG-------- ------------ACAC--AAAC--AAA---TGGA---AA--GACAT---------CCCA- --TGCTC------ATG-GATTAGAAGAATT-A---A---TATT--------------G-- TTAAAATG-----------------------------------------ACCAT--ACTG CCC-AA--AGCAATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--A---------------------CCAATA-TT---ATTTTT ------------------------------------------TACAGAAATAA------- ----------------------AAAAAAAAAT------CCTAAAA---TTTATATGGAAC C-------AAAAAAGAGCCC---AA--ATAGCCAAAGCAATCCTGAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACA---CTACCTGACTTCAAAAT-----A TATTAC-------------------------AA---GGCTATAGT-AACCAA---AAC-A GCA--------------TGGTATTGG--TA------------T---AAAAATAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAT-- -CCAT----------------ATA-------TTTACAG----CCAACT--GATTTTT--- GACAAA--GGCACCAAGAACATAC--A-------------------TTGGG--GA---AA GG------------ACACCCTCTT--CAATAAATGG---------------GGCTG---- ------G-GAAAAA--TGG-ATAACCA---------------TATGC-AGAAGA---ATG ---------AAACTAGACCCC---TTATT-----------TCCCCC--ATA--T---ACA AAAA-TCAACT-CAAAATGG---AT---TAAAGAC---TTAAATGTA--AGACCCGAAAC TAT------------------------AAAACTACTAGAA---------------GAAAA ---CATA-------------------------GGGAAAACACTTCAGGACATTG--GTC- -----TAGGCAAAGATT-----TTATGGCTAA-GACCTCA---AAAGCACAGGCAAC--- --AAAAACA---AA----AAT---AGACAAA-TGGGAC----------TATATT-AA--- ACTAAAAA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACAAT-------------CAACAGAGTGAAGAG------------------- ------A-------------CAACCT------GTTGAA--T-GGGAG---AAAATATTT- --GCAAACTATTCAT--------CC-------AACAAGGGAC--------TA--ATATC- ---CAGAATATACAAG-GA--ACTCAA---ACA------AC--TCAAC------------ ---AAA--AAAAAAACAATAAAAAAAAAAAAAAAT--AATCCCA-TTAA---AAAGTGGG C--AAA---------GGA--CATGA---AT---AGACATTT------------------- -----CTCAAAAGAA--------GACATAC---AA-ATGGCCAAC--AGGTATATGAAAA AAT----------GCTCAACATCACTA-ATCATCA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATATCA---------TCTT----ACCCCAGTTAGAATGGCTATTAT---T A--AAAAG-------ACAAAAA-----AAAAAA-AATATGT------------------- ------TGGT-AAGGATGTG----------GAAAA------------------------- ------------AAGGAAACTCTTAT-ACACTGTTGG--TGGG----------------- ----------AATGT--A-------------AATTT--AATAA----AACCAATAAGG-- ------AAAAAAATT--TGGAA--A-TTTCTT--AAAAAACTAAAA--ATAGAACTACC- -ATAT---AA--TCCAGCAATCCCA---------------------CTACTGGG-TATT- --------------TA-TCCAAAGGAA------------AAAAAATCA----G------- --------------TATATCAA--AGGGATACCTGC---------ACTCC----CATGTT TATT--GCAGCACTATTCACAA-TAGCAAAGATAT--G--GA--ATCA--ACCTAA---G TGTCCATCA---ATGGATG-----AATGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAT----ACACAATGGAATAC-----T--ATTTA GACATAA----AA----------------------AAGAATGAAATCATGTCATTT---- ------------------------------------------------------------ --------GCAGCAACATGGATGGAA-C---TGGAGGTCATTATGTTAAGTGA------- ------------------------------------------------AATAAGCCAGGC ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAG---------------------------------ACAAATAT-CA-------- ---CAT---GTTCTCACTCAT----------ATGTGGGAGCCT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAA-------AGTTGAT---------------CTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GAGGTAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GTAGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----GATAGAT-----------------------------------------------A CCA-------GAGGCTGGGA---------AGGGTGTGTGGGGGGGGGGGGGGGGGGGG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TGATGAAGAGAGGTT------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------GGTTAATGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAAACATACAGTTAGATA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GAAGGAATAAG------------------------------ ---------------TTCTAATGTTTGATAGCAGA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GTAGGGT-GACTATAG------------------------------------------- -------------------------TT-----------------AACAAC---------- --------------AATGTATTGTATATTTCAAAATAGCTAGAAGAGA------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GGACTTGAAATGTTCCCAACACATAGAAATGATAAA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------TACTTAGGGTGATGG ATACCCTAAATACCCTGACTTGATCATTACACATTCTATGCATGTAACAAAATA--TCAC A-TGTACCCCATAAATATGTACAAATATTATGTATCAATAAAA----------------- ------ >L1MA5 ------------------------------------------------------------ ------------------------------------------------------------ -----------TGACATCAGCAAG-----------------TTGGCTGACTACAAGGGGC CCACAACTC---------------------------TTCTCTCCACCAAA---------- ---------------------------------------AACGACCAAAACAACGA---- -ATAGATAACT------ACA---CTTTGAGTAGAATATCTAAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------GGAGAGTACTGGAATTCAGCAAGG------GAGTGACAGAA-------ACCCTG GGAGGCATAGAAACTCAGGATGGCCGCATAGAGA---------G-CGGAGCTAAGCAGAA GCATGCCACCTCGG----------GGCCTCA---------GCATCGCGACTGGCCTGAAC CGC-------------------------------------CAGCCAGGAGTGACCCTGAC CGTCGAGAGACTCTTCATTGCAGGGAAAAAGTAA-----GT---GGGAGATCCCCAGCAG CCCCCATTCCCAC---------------------------------------CATGGACG CCTGCAATCCTAGCTACAGGAGAGCCCCACAGCCCTCACAGGCCCTGAGCCCAGT----- ---------------------------------------------ATAGGGAGCTGCCTG GAGTCCACACGGCTGCATTGTCCCAGAGAAGGAACCCACACTGGGTCCCCCCCCCCCCCC TGGGCTCAAGGTGTCCTGG----------------------------------------- ------------------------------------------------------------ -----------------------CACGGGCTGCCCTCAGCTTCT----GTGATTTT--GA GAATGGAGCCACTGCTAGACTCCATCCTTCCCTGGGGCCCAATTGCCCCCGCATCCCCAC CTCCCTGGGGCCCT---------------------------------------------- -----------------------TCCCTGAGCCCCCCATCCCCCCGGGAGGCTGCGCCTT CGCAGCCCCAGCTAGACCCAGTGGTGGAGCTG-------------TGACCCGGGCACCTG GGCCCACTGGAAGATCGGTGCCGTGGCTCAGCGC----------------------CCCA GCTGCACCCGCCTGT------------TCGGGGCTC---ATGCAGTGCCCTACACTCCCA GGAACAGGTGGTGCAGCACATCAGGGAGGCTACCCCCAGCA------------------- ------------------------------------------------------------ ----CTCAGGGAGCCGATCCACCCGCTCCCCACGGCCCTG-------------------- ------------------------------------------------------------ -----------------GGGCCTGCCGCCCCGGCGTCCCGCCGCCAGCCGTCACCCCT-- ---------CCCCCTCCAGCGGCTGAGCCACCCTCTGCCTCCGTGCGCC--CCCCGCCCT GCTGGGCTGCCACCCACGCCGCCCACCCCTGCCCAAGCCGCTCGCCTCACAGAGTCTGTG ATATACTGACCCTCACTATTTCAGGGTCTAAAGTCACTACTACACAGTACTTAGTGCCCT GGAAGAGATGCTCCAAAAACC--------------------------------------- --------------------CTTGCCAGTC-------ACTGCTGTAGTTTGCTTCCTTGG GCTGGGAAAGAAACAAAGACAGGCATCCAGGGCAAATACTTCCACTGTTGCCCAGGTCAG TGCCACCACTAAAAGCCGCAGCTTCCCCAGTTACC------------------------- -CTCCTCTTCGGCCTGCTTTGCCCAGACTGTCCATATGATCCATG----TTCACTACTGC CGAGC-CCGTGCTGGTCCCACCCTTCGCGCAGATATCTCGCCCGGCCTGCCCGCCATA-- ------------------------------------------------------------ --------------------------------------------GCCACGCACCCCTCCC AGGGTTGTAAGGCTGGGGCCCCGCCTCCGTCCACCCTCCCCTCACAAGGCGAAGCGCCGC CGTGTC------------------------------------------------------ -----------------------------------------------------------C CCGCG-----------------ATTCGCCCAGGGGTTCGCCCTCACTTCAGGCCAACACC ATGGTGGCAGAGCC--------------------------------ACCACATGCCCCTT TG------------CCTGGCACCCCCGGCCACCCCCGCCTCCCGGACAGCGGTGCTGGCC CCTTTGCG---------------CGCTCTCTGGGGTC----------------------- ------------------------------------------------CTGGAGCCGGGC CGACCGGGGCCCCCCGCCCCCAGGAAAGCAGCAAC----TTTCCCCACTGGTGCCACAAA CTCCTGCAGCCTAGGCC------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------ACTGAGGCA-----------CTCGCAGACATTGCTGA CATTGATTACAGCTAAAG------------------------------------------ --------------------------AAATTATACAGAGACTACACT------------- --A-----------CTGCACCCACCCAGAACCAAAGCCAACGCACCCTAC---------- ----------------------------------------------CCAACCGACACCAT AGGACCCATCTACAGGAAAAAGTCTTTCCCTATAAAA--GCCACTCCA------------ ------------------------------------------------------------ -TAAAATTG-------------------GAAGAGGTGACTGTTCCACCAGATGCGCAGAT TGATGA------------------------------------------------------ -------------------------------TGCACAGACA-----TCAACACAGGGACA CAA-------------------------------------GAAACATGA--------AAA AGCA----GGGAAATA-------------CGAT--GCCA--CCAA---A-GG-------- -------AAC----ATAATAATTA-------------------TT-TGGTAACAGCAGAC CCCAATG----------------AAA---AGGAAATCAATTAATTGCCAGAAAA------ ------GGAA------------TTCAAAATAATGAT-TTTAAAGAAACTCAATGAGAT-- --ACAAGAAAATATA--------------------------GATAGATCATTC-----AA AAAAATA---------------------------------------------AAAATTTA T-GATCTAA--------------------------------------------------- --ATGACA------------AATTCAACAAAGAA-------------------------- -------------------------------------------AAAAATAAAAAAAAAAA ----------GAAC---------------CAAACAG------AAA---------TATTG- CAAC----TGAAG---------AATTC---AATGAATGAAATAAAAAATACAATCGAG-- ---AGCTTCAACAATAGA----------------CTAG--------------------AT C--AAGC------------------AGAAGAAAG-AAT-TTCTG--AACTTGAAGAT--- -AGGTCATTTGAAA-T-----AACTCAATCAG-----AAAAAAAAAAAAAAA---GAAAT AAAA---ATGAAAAAAGAA---------TAA---AGAAAACTTAT--AAGATTTATGGG- AACAC--------A---TTAAGTG-AAAAAAATATTCAA--A-TTATGGG--AGTT---- ----------CCAGAAG---AAGAAGAGATGGAA---AAAGGCATAG---------AAAA CCTATTT---AA-----TGAAATAATAGCT--GAAAACTTCCCAAGTCT----------- ---------TGGGAGAGATAT--GGAC--ATCCAGATCC-----AGGAAGCTCAAAGA-T TCCCAAATA------------GATTCAACCCC--------------AAAAAGGTCTTCTC T-------A---------------------AGGCAAATTATATTCAAATT------GT-- AAAAGTCAAAG---ACAAAG--AGAGAATTC----------------------------- -------------TAAAAAC--AGCAAGAGA---AAAGTATCAAGT-------------- -----------CAC---ATATAAGGG-AATCCCCA--------------TTAGACT--AA CAGCAGATTTC-----TCAGCAGAA--ACCTTA-CAGGC------CAG-GAGAGAATG-- -----------GGA-TGATATA-T-------TCAAAG--TGCT-------------GAAA GAAAA---------------AAATTG--CCA--GCCAAGAA--------TAC---TATAC CCA-----------GCAAAGCTATCC-----TTCAG-AAATGA-------AG-------- ------------------------G-AGAAATAAAGTCTTTCCCAGACAAGC-AAAAACT GAGGGA-ATTCATCACCACTAGAC---CAGCCTTAC-AAGAA------------------ --------------------ATGCTTAAGGG----------------------------- -----------------------------------AGTCC--------------TACATC TGG----------------------------------------------------AAAAG AAAAAGGATAA------------------------------------------------- -------------------------------TAATCACCATCATG--------------- ------------------------------------AAAACATTC--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------AAAA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- -----------------CTACATCTGGAAG-------------------------TGAAA GGATA---------------------------------------------ATAACTACCA TCATGAAAAC-ACACAAAAGTATAAAACTCACTGGTAGA--------------------- ---------------------GCAGATGAAAG---------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAGGAAT AAATCTTATCACTACA-GAAAACCACCAAACCACAAAGATAAACAATAAGAGAGGAAGAA AGG--------------------------------------------------------- ---------------------AACAAAGGATACA--------------AA---ACAACCA GAAAA------------------------------------------------------- ------------------------------------------------------------ -------------CAA----------TTAACAAA-------------------------- ------------------TAACA-------GGAGTAAGT--------------------- ------------------------------------------------------------ --------------------CCTCACCTA--TCAATAATAAC-CTTGAAT-------G-T AAAT--AGATT--AAATTC---CCCAATT----------------AAAAAAT------AT AGAC--TGGCTG----AATG---------GAT-------TAA----AAAAAAAACCCAA- ---CTA-------TAT-GCTGCCTA-AAAGAAACTCACTT-TACCT--TTAAAGACACAA A-TAGACTGAAAGTAAAGGAA---T------------GAAAA----A-AGATATTCCATA T--------------AAAAAG------AAACC---------------------AAAAA-A GAACAGGAGAGG----AGCTATACTTATATC-AGATAAAATAGACTTTAAG-TC------ ----AAAAAATA---TAAAAAGAGAC-AAAA-AAGGTTAT------TATAT------AAT GATAAA---GGGATCAATT------CAGCAA---GAGG--------AT-ATAAAAA-TTA TAA-----------------A----TATATATG---------CACCCAACACCAGAGCAC CCAG--ATA-TATAAAGCAAATATTATTAGATCT--AA----AGGGAGA---------GA TAGACTCCAAT------ACAATAATAGTTGGGGACTTCAACA----------------CC CCACT------CTCAGC-ATTGGACAGATCAT---------------------CTAGAC- -----AGAA-------------AATCAACAAAGAAACATTGGATTTAAAC-TGCACTATA GA------CCAAATGG---ACCTAACAGACATTTACA--GA----ACATTTCATCCAACA GC---TGCAGAATACACAT------TCTTCTCATCAG-----CA--CAT-GGAACATTCT --C----CAGGATAGACCATATGTTAGGCCACAAAACAAG-------------------- -TCTCAACAAATTTTTAAAAA--TTAAAAT----------------CATATCAA------ -GTATCTTTTCT---GACCACAATGGAA-TAAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------AG --------------AGG-AACTTTGG---AAACTGTACAA----ATACATGGAAA--T-T AAACAACATG-CTCCTGAA---TG-ACCAATG--GGTCAATAAAGA--AAT--T-AAAAA GAAAATT---------------AAAAAATT---T---AAAC------------------- ------AAATGAAAATAG-AAA------------CAAAAC--ATAACAAAACCAA-TGGA TA--------AAAAAAAACAGTA-----------------------------CTAAGAGG GAAG--TTTATAGCAATA----AAAGC----CTACATCAAAAAAG---TAGAAAGATTT- --CAAATAAAC-AACCTAA-TGATGCACCTC---AAGGAAC--TAGAAAAGC------AA GA-----ACAAACCAAAC-------------CCAAAAT--TAGTAGAA-GGAAAGAAATA ATA---AAGATCAGA-------------------GCAGAAATA---AA-T-AAAATAGAG ACTAA------AA------------------------------------AAA-------A AAAAAAAATA-A---------ACA----AAAAAA-AAATT---------TTTTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATCAACAAACTA---TTAG CTA------GACTAA--CTA------------A----------------------AAAAG A---GAGA-AGACCC-----------------AAATAAA--------TAAAA-----TC- ---------AGA-AACAAAA--AA----------GGAGA---CATTACAACTGATACC-A CA-GAAATA--CAAAGGAT-CATTAG---------AGACTATT--ATGAA---------- -----------CAA---CTATATACCAACAA---ATTGGAAAACCTAG---AGGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----AACCTACCA----- -AGATTGAACCA---AGAAGAAATAGAAAACCTGAAC----------------------- AGACC------------AA-TAATAAGTAATAAGATTGAAT-C---------AGTAAT-- -AAAAAGTCTCCC------AACAAAGAAAAG---CCCAGGACC--AGATGG--------- ------------CTTCACT-GCTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAAGAA-GAACTAA--TA-CCAATT----------CTTCTCAA ACTATT----CC---AAAAAATTAAA------GAGAAG-GA-----------AATTCTTC CAAACTCATTCT-----ACAAGGCC-----AGCAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGAC AAG---------------------GAC---ACAACAAAAAA---AGAAAACTAC------ -------------A-GGCCAATAT---CCC----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAA------ ----AAACCA------------------AA--TC--------------CA--ACA----- --------GCACATC---------AAAAAGATTATACA--CCATGAT------------C AAG---TGGGA-TT----------TATCCCA------------GG--GATGCAAGGATGG -T----------------------TC-AAC-----ATATAC--AAATCAATAAA--TGTG ---ATACATCACAT------CAACAG----AATGAAGGACAAAAAC---CATATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTTGATAA---AATTCAACATCCCTT- ---------------CATGA---------T---A--AA-----AACTCTCAAC---AAAT TAGGTATAGAAGGAATAT-----ACCTCAACACAATAAA--------------------- ------GGCCATATAT-GACAAA--------CCCACAGC-----------TAACAT--CA TACTGAATGGGGA-----AAA-GCTGAAAGC----TTTT---CCT----CT--AAGAACT GGAACA----AGACAAGG-ATGC--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTTTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------TAG-GC------AAGAG---AAAGA --AATAAAGGGCATCCAAATTGGA---AAGGAG------GAAGTCAAA--T--------- ------TGTCCCTG-TT--T---GCAGA------TGACAT------GATCTTATATATA- -GAAAAAC--CTAAAGA---CTCCACCA---------A---------------AA--AAC TCTTAGAACT---------GA--TAAATAAATTCAGTAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------CAT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCATTTC--TA-TACACCAAT---------------AATAAACTAG-----CTG A------------------AAAAGAAATC-AAG----AAAGCAATCCCATTTACAATAGC T---------------------AAAAAAAAA------------------TACCTAGGAAT AAATTT--------AA--C-CAAGGAGGTG---A---AAGATCTCT---ACAA-TGAAAA CTATAAAACAC------TGATG-AAAGAAATTG-AA------------GAAG-------- ------------ACAC--AAAA--AAAAAATGAA---AA--AAAAT---------CCCA- --TGTTC------ATG-GATTGGAAGAATT-A---A---TATT--------------G-- TTAAAATG-----------------------------------------ACCAT--ACTA CCC-AA--AGTAATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--A---------------------CCAATG-AC---ATTCTT ------------------------------------------CACAGAAATAG------- ---------------------AAAAAAAAAAT------CCTAAAA---TTTATATGGAAC C-------ACAAAAGACCCC---AAATATAGACAAAGCAATTCTGAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACA---CTACCTGACTTCAAAAT-----A TACTAC-------------------------AA---AGCTATAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--CA------------T---AAAAACAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAT-- -CCAT----------------ATA-------TTTACAG----CCAACT--GATTTTT--- GACAAA--GGTGCCAAGAACATAC--A-------------------TTGGG--GA---AA GG------------ACAGTTTCTT--CAATAAAGG----------------TGCTG---- ------G-GAAAAC--TGG-ATATCCA---------------TATGC-AGAAAA---ATA ---------AAACTAGACCCT------CT-----------CTCACCATATA--T---AAA AAAA-TAAACT-CAAAATGG---AT---TAAAGAC---TTAAATGTA--AGACCTGAAAC TAT------------------------GAAACTACTAGAA---------------GAAAA ---CATA------G------------------G-GGAAATGCTTCAGGACATTG--GTC- -----TGGGCAAAGATT-----TTATGGATAA-GACCTCA---AAAGCACAGGCAAC--- --AAAAACA---AA----AAT---AGACAAA-TGGGAT----------TATATC-AA--- ACTAAAAA-----G------------CTT-CTGCA-------CA--------------GC -AAAGGAAACAAT-------------CAACAGAGTGAAGAG------------------- ------A-------------CAACCT------GCAGAA--T-GGGAG---AAAATATTT- --GCAAACTATTCAT--------CT-------GACAAGGGAT--------TA--ATATC- ---CAGAATATACAAG-GA--ACTCAA--------------------------------- --------------------AA--AAATA---AAC--AACAAAA-TTAA---AAAATGGG C--AAA---------TGA--TCTGA---AT---AGACATTT------------------- -----CTCAAAAGAA--------GACATAC---AA-ATGGCCAAC--AAGTATATGAAAA AAT----------GCTCAACATCACTA-ATCATCA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATATCA---------TCTC----ACCCCAGTTAGAATGGCTATTAT---C A--AAAAG-------ACAAAAA-----AAAAAA-AATG--T------------------- ------TGGT-GAGGATGTA----------GAGAA------------------------- ------------AAGGAAACTCTTAT-ACACTGTTTG--TGGG----------------- ----------AATGT--A-------------AATT---ATAAC----ACCCATTATGA-- ------AAAACAGTA--TGAAG----TTTCCC--AAAAAACTAAAA--ATAGAACTACC- -ATAT---GA--TCCAGCAATCCCA---------------------CTACTGGG-TATA- --------------TA-TCCAAAGGAA------------AGGAAATCA----G------- --------------TATATCAA--AGAGATATCTGC---------ACTCC----CATGTT TATT--GCAGCACTATTCACAA-TAGCCAAGATAT--G--GA--ATCA--ACCTAA---G TGTCCATCA---ACAGATG-----AATGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAT----ACACAATGGAATAC-----T--ATTCA GCCATAA----AA----------------------AAAAATGAAATTTTGTCATTT---- ------------------------------------------------------------ --------GTGGCAACATGGATGAGC-C---TGGAGGACATTATGTTAAGTGA------- ------------------------------------------------AATAAGTCAGGC ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAG---------------------------------ATAAATAC-TA-------- ---CAT---GTTCTCACTCAT----------ATGTGGAAGC---CT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAA-------AGTTGAT---------------CTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------GAAGTAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GTAGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTGGTT-----------------------------------------------A CTA-------GAGGCTGGGA-----------------------AGGGTAGGGGGGAGG-- -------------------------------------------------GG--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------GGATAGGGAGAGG--------------- ------------------------------------------------------------ -------------------------TT--------------------------------- ---------------------------------GGTTAATGGATA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAAAATTACAGCTAGATA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GGAGGAATAAG------------------------------ ---------------TTCTAGTGTTCTATAGCACT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GTAGGGT-GACTATAG------------------------------------------- -------------------------TT-----------------AACAAT---------- --------------AATTTATTGTATATTTTCAAATAGCTAGAAGAGAGGATTTTGAATG TTCCCAACACAAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAAATGATAAATGTTTGAGGTGATGGATATGCTAAT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TACCCTGATTTGATCATTACACATTGTATACATGTATCAAAATA--TCAC TCTGTACCCCATAAATATGTACAATTATTATGTGTCAATTAAAAA--------------- ------ >L1MA5A ------------------------------------------------------------ ------------------------------------------------------------ ------GAGAGTGATGTCAGCAAG-----------------ATGGCTGACTAGAGATGCC TGGCATTCA-----------------------------TCCCCCACAAAAA--------- ---------------------------------------AAGGGCCAAAGCAACGA---- -----------ATAAACAGCTAAGATTTGACTGGAGTGTCGAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GGGA------GAGTGCTGGAGTGCAGCAGGGGAG TGGAGATGCACCTGTGGTGACTGGAAGTCCAGGA---------G-GGCAGCATGGAGGCA CCTGGCCTCTGCAG---------------------------------------------- ------------------------CCTCATCTCCCCCACCTGGATCAGATTGGCCTAGAG TCAGGAGGGACTTCCCATTGTGGGGAAAAGGTAAGCA-------GAAGATCCCCACCAGC CCCCATTGCCAC----------------------------------------TGCAAACA CCTACAGTCCTTACTACAGGAGAATCCCACAGTCCTCACAAGCCCTGAGCCCAGT----- ---------------------------------------------TTGGAGAGCTGCCGG GAATTCATGCAGCTGCATTGCCCCAGATTAGGAGCACAAGGTGTGCACTCCCCCCACCCC C----------------------------------------------------------- ------------------------------------------------------------ -------------------------------ACCCACCCCCTGTGAGCCAAGCTGCTGCA GCATGGTGCCATCTTGAGACCAGAGCCACCTCTGGAGTGCACCCTGCTCTGGGGGCCAGT AGCCACTGCACCTCTC-------------------------------------------- -------------------CAGCACTGGGGCTCCATCTTCATTCCACCAAGCCCACACAG GTGGCTGAATGCCACAACCCCAGCTGTGCGGAGCCTGGGCCCAGGATTGGCTGTGACTCT GGTCCTGCACATCAGGGAAACCAACCCCTGCCTC-------------------------- ---------------------------------------CCCCACCTTCCAGCAAGAGAA ACGGTTTGCCGTTCCACC---CAGGGCAAACCCACCCTTGA------------------- ------------------------------------------------------------ ----GCCAGCCAAACTACTGTGTGC----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------CCTCCCCCGAGCAGGAGAGGTCCCCAAGCCACCAAGCAGCTGACATGCC-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CCCAGGCCAG-------CCGAGTGGCTATGTGCCCATGCC CAGGGCCTGAGAAACAGCCCCGTGGGTC-------------------------------- ------------------------------------------------------------ ---------------------------------CCCCCCGGCAAACAGACCCCCAGGCCA GCTGAGCAGCTGTGCACCCACATCCCAGGCC----------------------------- ------------------------------------------------------------ --------------------------------------------TGAAAAACAGCCCCAT GGGCCCCCCCCAGTGGACACGCCCCCAGGCCAGCCAAGCAGCCTTGTACCCACATCC--- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------TGGGCCTGAGAAACAGCCCTGTGGGCCAATATGCCCAC AGGTTGGACGAGCA--------------------------------GCTATATGGCCATG TC---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------CCAGGTCCAAAAGAGTCCTGTGGGCCACCACCCACAGAAACGCCCCAAAC CAGCCAAGCAACTGTGCAGTTATATCGTGGGC---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------CTGACAAACAGCCCTGT ACCCACCCATGGTAGCCATGCCCACCCAGGCTGGTCAGGCCACTGCATGCCCATGTCTCA AGCTGGAGAAATGGCCTTGGTAGGATGCCCTCCCCCCCGGCCAATTGAGCACTGCTGTGT TTC-----------ATAGGCCCATGTCTCATGCCTAAGAACCCGTCTCAC---------- ----------------------------------------------AGGCAACCCCCGGC AGACACACCCCCAGGCCAGCCGAGCAGCCTTGTGCCTGTGTCCTGGGCCTG--------- ------------------------------------------------------------ -AGAAACAGCCCTATGGGCTGCCC------------------------------------ ------------------------------------------------------------ -------------------------------CTGGCAGACATGCCCCCAGGCCAGCCGAG CAGCTGTGTGCCC---------------------------GCATCCTAGGCCTGAGAAAC AGTCCTATGAGCTGCTCCTGGCAGGAAACCCCTCAGGCTGGCCAAGCAACCACATGCCCA TGCTCCTAGCCAGAGTAACAGCCCTGTGG--------------CCCCAACCCCAGCGAGC CAGACCC-----------------------TAAGTTGGCTGACCCATCATGTGC------ ------ATG-------------CACGTGCCCCCGACCTGAGAAACAGCCCAGTGAGCCCA CCCCTGGCAAAGCCA--------------------------------CACCACTGCCACC ACAAATTCTCTCAGCCTAGGCCACTGAGACACTCACAAATGTCACTAGTGTGGATTACAG CTGAAGAAA--------------------------------------------------- ------------------CTACATGGAGACTACACTACT--------------------- -------------------------------------------GCATCCACCTAGAACCA ----------AAGC---------------CAACACACCCC--ACC--------------- AAAC----TGACA---CCCCAAGACCC---ATCTATACGAATAAGTCTTTCCCTACAA-- ---AACCTACTCCATAAA----------------ATTGGAAGAGGTGACTTTTCCACCAG C--AAGC------------------AGAAGAAA--AAT-TTCAG--AACTTGAAGAT--- -AGATCTTTTGAAA-T-----AACACAA-------------ACACTGGCAAA---AAAAA AAAA------AAAAAA-AA---------TGA---AAAAAAGCTAC--AGGA--------- -------------------------------------------TTTTTGG--TGTT---- ----------CCACAAGGAAAAGAAAAGAAT------AAAGGTAAAG---------AAAA CATATTT---AA-----TGAAATAATAGCT--GAAAACTTCCCAAGTCT----------- ---------TGGGAGAGAGAT--GGAC--ATCCAGATCC-----AGGAAGCTCAAAGA-A CCCCAAATA------------GATTCAA-CCC--------------AAAAAGGTCCTCTC C-------A---------------------AGGCACATTATAGTCAAATT------GTC- AAAAGTCAAAG---ACAAAG--AAAAAC-------------------------------- -------------TAAAAAC--AGCAAGAGA---AAAGCATCAAGT-------------- -----------CAC---ATATAAGGG-AATCCCCA--------------TTAGACT--AA CAGTGGATTTC-----TCAGCAGAA--ACCTTACAGAGC------CCAAGAGAGAATG-- -----------GTA-TGATATA---------TAAAAA--AGAC-------------AAAA AAAAA---------------AAACTGTCTCC--GACAAGAA--------TAT---TATAC CCA-----------GCAAAGCTATCC-----TTCAG-AAATGA-------AG-------- ------------------------G-AGAAATAAAATCTTTCACAGACAAGC-AAAAACT AAGGGA-ATTCATCACCACTAGAC---TAGCCTTAC-AAGAA------------------ --------------------ATGCTCAAAGG----------------------------- -----------------------------------AGTCA--------------TACATC TGG----------------------------------------------------AAATA AAA--------------------------------------------------------- -------------------------------CTCACTGGTAGAGCC-------------- ------------------------------------AATACAC----------------- ------------AAAGGAGAAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GAAAGGAATC AAACCTTATCACTACA-GAAAACCACCCAACCACAAAAATAAACAATAAGAGAGGAAGTA AGGAA------------------------------------------------------- ---------------------CAAAGGATATACA--------------AA---ACAACCA GAAAA------------------------------------------------------- ------------------------------------------------------------ -------------CAATCAATAAA------------------------------------ ------------------TGACA-------GGAGTAAGT--------------------- ------------------------------------------------------------ --------------------CCTCACCTA--TCAATAATAAC-CTTGAAT-------G-T AAAT--AGATT--AAATTC---CCCATTT----------------AAAAGAT------AT AGAC--TGGCTG----AATGGATTAAAAAAAT-------AAAAAAAAAAAAAGACCCAA- ---CTA-------TAT-GCTGCCTA-CAAGAAACTCACAT-CACCT--GTAAAGACACAC A-TAGACTGAAAGTGAAGGGA---T------------GGAAA----A-AAAATTTTCAAT C--------------AAAAAG------AAAAC---------------------AAAAA-G AAGCAG--GAGT----AGCTATACTTATATC-AGACAAAACAGACTTCAAG-TC------ ----AAAAACTG---TAAAAAGAGAC-AAAG-AAGGACAT------TATAT------AAT AATAAA---GGGATCAATT------CAGCAA---GAGA--------AT-ATAACAA-TTG TAA-----------------A----TATATATG---------CACCCAACACCGGAGCAC CCAG--ATA-TATAAAGCAAATATTATTAGATCT--AA----AGGGAGA---------AA TAGACCCCAAT------ACAATAATAGTTGGGGACTTCAACA----------------CC CCACT------CTCAGC-ATTGGACAGATCAT---------------------CTAGAC- -----AGAA-------------AATCAACAAAGAAACATTAGATTTAAAC-TGCACCATA GA------CCAAATGG---ACCTAACAGACATTTACA--GA----ACATTTCACCCAACA GC---TGCAGAATACACAT------TCTTTTCATCAG-----CA--CAT-GGAACATTCT --C----CAGGATTGACCATATGTTAGGACACAAAACAAG-------------------- -TCTCAAAAAATTTTTAAAAA--TTAAAAT----------------TATATCAA------ -GTATCTTATCT---GACCACAATGGAA-TAAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------AG --------------AGA-AACATTCG---AAACTATACAA----ATACATGGAAA--T-T AAACAACATG-CTCCTGAA---TG-ACCAATG--GGTGAAGGAAGA--AAT--T-AAGAA TGAAATT---------------TAAAAATTCCTT---GAAAC------------------ ------AAATGAAAATAG-AAA------------CACAAC--ATACCAAAACCTA-TGG- GA-----CACAGCAAAAGCAGTA-----------------------------TTAAGAGG CAAG--TTTATAGCAATA----AATGC----CTACATCAAAAAAC---TAGAAAGATTT- --CAAATAAAC-AACCTAA-TAATGCACCTC---AAAGAAC--TAGAAAAGC------AA GA-----ACAAACCAAAC-------------CCAAAAT--TAGTAGAA-GGAAAGAAATA ATA---AAGATCAGA-------------------GCAGAAATA---AA-C-AAAATTGAG ACTAA------AA------------------------------------AAA-------T ACAAAAGATC-A---------ATG----AAACAA-AAAGTTG------GTTTTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATTGACAAACCA---TTAG CTA------GACTAA------------------GAAA------------------AAAAA A---AAGAGAGAAAC-----------------AAATAAA--------TAAAA-----TC- ---------AGA-AATGAAA--AA----------GGAGA---CATCACAATAGATACC-A CA-GAAATA--CAAAGGAT-CATTAG---------AGACTACT--ATGAA---------- -----------CAA---CTATATACCAATAA---ATTTGAAAACCTAG---AGGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----AACCTACCA----- -AGATTGAACCA---AGAAGAAATAGAAAACCTGAAC----------------------- AGACC------------AA-TAACAAGTAATAAGATTGAAT-C---------AGTAAT-- -AAAAAGTCTTCC------AACAAAGAAAAG---TCCAGGACT--GGATGG--------- ------------CTTCACT-GCTG--AA-------------------TTCTA-------- ----CCAAACCTTT---AAAGAA-GAATTAA--TA-CCAATT----------CTTCTCAA ACTATT----CC---AAAAAATTGAA------GCGGAG-AA-----------AATTCTTC CTAACTCATTCT-----ATGAGGCC-----AGCAT---AACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGAC AAG---------------------GAC---ACAACAAAAAA---AAAAAACTAC------ -------------A-GGCCAATAT---CCC----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACCA------------------AA--TC--------------CA--ACA----- --------ACACATC---------AAAAAGATAATACA--CCATGAT------------C AAG---TGGGA-TT----------TATCCCA------------GG--AATGCAAGGATGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--TGTG ---ATACATCACAT------CAACAG----AATGAAGGACAAAAAC---CATATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTTGATAA---AATTCAACATCCCTT- ---------------CATGA---------T---A--AA-----AACTCTCAAT---AAAT TAGGTATAGAAGGAAAGT-----ACCTCAACACAATAAA--------------------- ------GGCCATATAT-GACAAA--------CCCACAGC-----------TAACAT--CA TACTGAATGGGGA-----AAA-GCTGAAAGC----TTTT---CCT----CT--AAGAACT GGAACA----AGACAAGG-ATGC--CCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCTTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------TAG-GC------AAGAG---AAAGA --AATAAAGGGCATCCAAATTGGA---AAGGAG------GAAGTCAAA--T--------- ------TGTCCCTG-TT--T---GCAGA------TGACAT------GATCTTATATATA- -GAAAAAC--CTAAAGA---CTCTACCA---------A---------------AA--AAC TCTTAGAACT---------GA--TAAATAAATTCAGTAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------CAT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCATTTC--TA-TACACAAAC---------------AACAAACTAG-----CTG A------------------AAAAGAAATC-AAG----AAGGCAATCCCATTTACAATAGC TACA------------------AAAAAAATA---------AAA------TACCTAGGAAT AAATTT--------AA--C-CAAGGAGGTG---A---AAGACCTCT---ACAA-GGAAAA CTACAAAACAC------TGATG-AAAGAAATTG-AA------------GAGG-------- ------------ATAC--AAAT--AAA---TGGA---AA--GACAT---------CCCA- --TGCTC------ATG-GATTGGAAGAATT-A---A---TATT--------------G-- TTAAAATG-----------------------------------------ACCAT--ACTA CCC-AA--AGCAATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--A---------------------CCAATG-AC---ATTCTT ------------------------------------------CACAGAAATAG------- ----------------------AAAAAAATAT------TCTAAAA---TTTATTTGGAAA C-------AAAAAAAACCCC---AA--ATAGCCAAAGCAATCCTGAGCA---AAAA--GA AAA---AAGC--T-------GAA--GGCATCACA---CTACAAGACTTCAAAAT-----A CA----------------------------------AACTATAGT-AAACAA---AACTA GAA--------------GGCAACTGGCACA------------T---AAAAACAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATTAAT-- -CCAC----------------ATA-------TCTACAG----CCAACT--GATTTTT--- GACAAA--GATGCCAAGAACACTC--A-------------------TTGGG--GA---AA GG------------ACAATCTCTT--CAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-ATATCCA---------------AATGC-AGAAAA---ATA ---------AAACTAGAACCC---CCACT-----------CTCACC--CTA--T---AAA AAAA-TCAACT-CAAAATGG---AT---CAAAGAC---CTAAATGTA--AGACCTGAAAC TAT------------------------AAAACTACTAGAA---------------GAAAA ---TATA-------------------------GGGGAAATGCTTCAGGACATTG--GTC- -----TGGGAAAAGATT-----TTATGAATAA-GACCTCA---AAAGCACAGGCAAC--- --AAAAGCA---AA----AAT---AAACAAA-TGGGAT----------TATATT-AA--- ACTAAAAA-----A------------CTT-CCGCA-------CA--------------GC AAAAGAAAACAAT-------------CAACAGAGTAAAAAG------------------- ------A-------------CAACCT------ACAAAAAAT-GGGAG---AAAATATTT- --GCAAACTATTCAT--------CT-------AACAGGGGAT--------TA--ATATC- ---CAGAATATACAAG-GA--ACTCAA---ACA------TC--TCAAC------------ ---AGC--------------AAAAAAAAA---AAA--AATCTTA-TTAA---AAAATGGG C--AAA---------TGA--TCTGA---AT---AGACATTT------------------- -----CTCAAAAGAA--------GACATAC---AA-ATGGCCAAC--AAATATATGAAAA AAT----------GCTCAACATCACTA-ATCATCA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GGTATCA---------TCTC----ACCCCAGTTAGGATGGCTATTAT---C A--AAAAG-------ACAAAAA-------AAAAAAATG--C------------------- ------TGGT-GAGGGTGCG----------GAGAA------------------------- ------------AAGGGAACTTTTTT-AAACCGTTGG--TGGGA---------------- ----------AATTA--A-------------AACT---AGTAA----AGCCACTATGG-- ------AGAACAGTA--TGGAG--G-TTCCTC--AAAAAACTACAA--ATAGAACTACC- -ATAT---GA--TCCAGCAATCCCA---------------------CTACTGGG-CATT- --------------TA-TCCAAAGGAA------------AGGAAAATA------------ ------------AGTATATTAA--AGAGACATCTGC---------ACCCC----CATGTT TATT--GCAGCACTATTCACAA-TAGCCAAGATAT--A--GAGTATAA--CCCTAG---G TGTCCAACA---ACGGATG-----AATGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAT----ACACAATGGAATAC-----T--ATTCA GCCATAA----AA----------------------AAGAATGAAATCCTGTCATTT---- ------------------------------------------------------------ --------GTAGCAACATGGATGGAA-C---TGGAGGACATTATGTTAAGTGA------- ------------------------------------------------AATAAGCCAGGA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAG---------------------------------TTAAACAC-TG-------- ---CAT---GTTCTCACTCAT----------ATGTGGACTA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAA-------AGTTGAT---------------CTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------GAAGTAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAA--------GTAGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGAGGAT-----------------------------------------------A CTA-------GAGGCTGGGA-----------------AGGGTAGGGGGAAGGGGGGGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------TAGGGAGAGATT------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TGTTAAAGGATA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAAAATTACAGCTAGATA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GGAGGAATAAG------------------------------ ---------------TTCTAGTGTTCTATACCACT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GTAGGAT-GACTATAG------------------------------------------- ------------------------------------------TTAACAAT---------- -------------------AATATATAGTTTCAAATAGCTAGAAGGAGGATATTGAATGT TCCCAACACAAA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAAATGATAAATGTTTGAGATGATGGATATGCTAAT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------TACCCTGATCTGATCACTATACATTATATGTATCGAAACA--TCAC TATGTACCCCATAAATATGTACAATTATTATGTGTCAATTTAAAAAA------------- ------ >L1MA8 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------CAGGCTCCAGGTCTTCCCAGTGCCAGG CTTGTCTCT-----------------------ATGTCTTTACCCTCCAAA---------- ------------------------------------------------------------ -----------------CCAGTCCTTACACCCTAGTGTTCCAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------CAGACTCATAG------------- --------TTCAAGTAAGTCCCAGTAGACCCAAG---------CACTGGAGAAGCCAGTC CCCAGGCTTTCCCT---------------------------------------------- ---------------------------------------------------CCAGGTCCC AGGACTTTCCCTTTGTGCCCAGGTTCCAGGTCAG-----CC---CCTGAGGCCCTAAGAA CCAGGCCACCCT----------------------------------------CAGGGACT TAACCTCTCGGTAAGTCCGTACAGAACCATCCTCTAGTCAGCCCCCACTGGAAGACCGAT TTAGACAGATATGTGT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCACAAAGATTCCTGGGCAACCCATAAAA GAACCAGGTGAATGACAACAATAATTGATCATGAGGATCTGTCAAAGAACTCGGCAATAT GTTGGGCCAGTGGTGC-------------------------------------------- --------------------------------------------AGGTCATGTTACATTA CTCCTCGCTCCCTAGGATCAATAGTGAGGAGT-------------AAACCCAGGAGACCG GAATTCTTGACTTAAGGA------------------------------------------ ---------------------------------------AAAAACAGGGTTCAGAGGGAC AACTTTGACGATTAAGTCCACAAGGATGCAGCCCTCGGCAA------------------- ------------------------------------------------------------ ----AGTCCCTCGGTACCTGCCAGCGGTGTCCGC-------------------------- ------------------------------------------------------------ ----------------------------------------TTCCTCCCCGGGTCCGCC-- ---------CCAGGCTCGCCTCTCGTGACTCACTCACAAGAACCATGCCTCCGACAGGCC CGGCGCTATCAACCCAGGCTTCAGGGTGGC------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CTCTATACAC-------TCAGCCACTCAGTCCGTTCTTAT GGGACAAGGCGGAAGGCCGACACCGCTG-------------------------------- ------------------------------------------------------------ ------------------CAACCCCAGACTACGCCTCCCCCCGCACATCCAGTATCTACT CCCAA-CCCTAGGACCTCCAGCTCCCTGCTCCTCCACCTGCCAACGCACC---------- ------------------------------------------------------------ --------------------------------------------CAGCTGCACGGACTGC CCAAGGTCTCAAACGGCGCGCCCGCTCATGGCACAGCCCATATGCC-------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CTACCCAGCATGTCCCGACCG GCTGACTGGTAAAG---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GAATTTCCCCGACAAAGCCAGCCCGTGAAGT----CTAGAAGAGGTCCTTACTTCT TCAAATGCATAGACATCAATCTAGGG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------CAACAAGAA-----------ACAGGAAAAACAAGGAA AGCGTG------------------------------------------------------ --------------------------ACAACACCAAAAGAATAAAAT------------- --A-----------ATCCACCATTGGCGACCCTCTAAATATAGAT--------------- ----------------------------------------------ATATAAACTGCCTG ACACAGGATTCAAAATAATTGGTTTAGGGAAGCTCAGTGAACTACAGGAAA--------- ---------AAAAA---------------------------------------------- -TTAAAAAATTTCAGAAAGATAAGAAAAAAATAACTGGA--------------------- ------------------------------------------------------------ -------------------------------CAAAGTGAAATATTTAAAAAAAAGAAA-- ----------------------------------------GAAATAAAA--------AAA AACAAAAATAAAACTT-------------------GAAGAAGTAGAAGAAAA-------- -------ATA----ATAAAAATTT-------------------ATTAAGAAAAGAAATAA CAAAA------------------AAAAAGAAGAAATGGAAAAGACAATGAA--------- ------AGGA------------TCAAAAAGAA-----AAAAGAATGAATCATTGAGGACA AAAAAGGTAGAGTTTAA------------------------TAAACATGAGA------AG AGAAAAA----------------------------------------------------- --GGAAAAG--------------------------------------------------- -AAATAAA----------AAAAAGTAAAAAAAGA-------------------------- -------------------------------------------ACAAATAGTTTATGTAA ----------------------CACAGTATAAAGAGC-----AAATGTATGAGTTGTTG- GAGT----TAAAG-----------------AGGGAGAGGAGAAAAACAAAGGGGCAAATA T--ATCATTGACAGCAAA----------------GTTG--------------------AT C--AAAC------------------AGAAGAAAG-AAT-CTGTG--AACTTGAAGAC--- -ACATTATTTAAAAAT-----ATAGCGAGGAT---------------TAAAA---AGAAA AAGA---ATAAAAAGG-AA---------TAA---AAAAACTTTCA--GGAACTTATGGGA ACAGC--------A---TCAAAAG--AGCAATTGTTTGA--G-TTATAAG--TGTTTAAA TAGTTATCAATTTATAGGGAAAAAAAAAAAAGAA---AAGGGGGTAG---------AAAG CTTATTT---AA-----AGAAATAATAGCA--GAAAACTTTCCAAATCT----------- ---------GGAGAAAGATAT--AAAT--ATCCAGGTAC-----AGGAAGGTCAAAGG-T CTCCAATCA------------GATTCAA-TCC--------------AAACAAGACTACAC C-------A---------------------AGACATATTATAATCAAATT------GTC- AAAAATCAAAG---ACAAAG--AGAAAATCT----------------------------- -------------TGAAAGC--AGCAAGAGA---AAAGAAGCAAAT-------------- -----------AAC---ATATAAGGG-AGTTCCAA--------------TAAGGCT--AA CAGCAAATTTT-----TCAGCAGAA--AACTTA-CAGGC------CAG-GAGAGAGTG-- -----------GGA-TGATATA-T-------TCAAAG--TGCT-------------GAAG GAAAA---------------AAATTG--CCA--ACCAAGAA--------TAC---TGTAC CCA-----------GCAAAGTTGTCC-----TTCAG-AAATGA-------AG-------- ------------------------G-AGAAATAAAGACTTTCCCAGACAAAC-AAAAGCT GAGGGA-GTTCATCACCACCAGAC---CTGTCTTAC-AAGAA------------------ --------------------ATGCTAAAGGG----------------------------- -----------------------------------AGTTC-------------TTCAAGC TGA----------------------------------------------------AAGAG AAAGGAGGCAAGTTAGCAAATTAGTAACACAAAAACATATGAAAATATAAAACTCA---- -------------------------------CTGGTAAAAGTA----------------- ------------------------------------AGTACAC----------------- -------GGCCAAATTGAATACTCTAATACTGTAATGG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----TGGTGTGTAAATCACTTATATCTTTAGTATGAAGGTTAAAAGACAAAACTATTAA AAATAATAAA--------GGCAAAATTAATTTGTTAGGGCATACATAATTTACAGGAACA GCTACAGTGAATTCCTCAATCTATAATAATTTGTTAAGAGATATACAATATAAAA----- --------------------AGATGTAAATTGTGACATCAAAAACATAAAATGTGGGGGG GGGGGTGGAAAGAAAAGGTAG--------------------------------------- ------------------------------------AGATTTTAGAATGTAAGGCATAAA GTGTAGAGTTTTTT---TATGTAATCAAAGTTAAGTTGTTATCAGCTTAA---------- --------AATA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GC-------- --------------------CTGTTATAAC-------------------------TATAA GATGTTTTATGTAAGCCTCATG----------------------------GTAACCACAA AGCAAAAACC-TATAGTAGATACACAAAAGATAAA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AAGTAAGGAA TCAACACACCACTAGA-GAAAATCACCTAATCACAAAGGAAGACAGCAAGAGAGGAAGAA AGAAAAA----------------------------------------------------- ---------------------AAAAAGATCCACA--------------AA---ACAACCA GAAAA------------------------------------------------------- ------------------------------------------------------------ -------------CAAT------------------------------------------- ------------------TAACA------AATAGTAAAT--------------------- ------------------------------------------------------------ --------------------CCTTACCTA--TCATTAATTAC-CTTGAAT-------G-T AAAT--GGATT--AAATTC---TCCAATC----------------AAAAGAC------AT AGAG--TGGCTG----AATG---------GAT-------TAAA---AAAAAAAAACCAA- ---AAT-------TAT-ACTCCCTA-CAAGAGACTCACTT-CACAT--TTAAGGACACAC A-TAGACTGAAAGTGAAGGGA---T------------GGAAA----A-AAATATTCCATG C--------------AAATAG------AAACC---------------------AAAAG-A GAGCAG--GAGT----AGCTATACTTATATC-AGATAAAATAGACTTTAAG-TC------ ----AAAAACTG---TAAAAAGAGAC-AAAG-AAGGTCAT------TATAT------AAT AATAAA---GGGATCAATT------CATCAA---GAAG--------AT-ATAACAA-TTA TAA-----------------A----TATATATG---------CACCCAACATTAGAGCAC CTAA--ATA-TATAAAGCAAATATTAATAGATCT--GA----AGGGAGA---------GA TAGACTGCAAT------ACAATAATAGTAGGGGACTTTAATA----------------AC CCACT------TTCAAC-AATGGACAGATCAT---------------------CCAGAC- -----AGAA-------------AATCAATAAGGAAACATTAGACTTAAAC-TACACTTTA GA------CCAAATGG---ACCTAACAGACATATACA--GA----ACATTCCATCCAACA GC---TGCAGAATACACAT------TCTTCTCAACTG-----CA--CAT-GGAACATTCT --C----CAGGATAGATCATATGTTAGGCCACAAAACAAG-------------------- -TCTTAACAAATTTAAGAAGA--TTGAAAT----------------TATATCAA------ -GTATCTTTTCT---GACCACAATGGTA-TAAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------GG --------------AGG-AATTTTAG---AAAATTCACAA----ATACATGGAAA--T-T AAACAACATG-CTCCTGAA---CA-ACCAATG--GGTCAAAAAAAA--AAT--T-AAAAG GAAAATT---------------AAAAAATTTCTT---GAGAC------------------ ------AAAAAAAAATGG-AAA------------CACAAC--ATACCAAAACTTA-TGG- GA-----TACAGCAAAAGCAGTT-----------------------------CTAAGAGG GAAG--TTTATAGCAATA----AATAC----CTACATAAAAAAAA---AAAAAAAAAAT- --CAAATAAAC-AACCTAA-TATTACACCTC---AAGGAAC--TAGAAAAAG------AA GA-----ACAAACTAAGC-------------CCAAAGT--TAGTAGAA-GGAAGGAAATA ATA---AAGATCAGA-------------------GCAGAAATA---AA-T-GAAATAGAG ACTAG------AA------------------------------------AAA-CAA---T AGAAAAAATC-A---------AAA----AAACTA-AGAGTTG------GTTTTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATTAACAAACCT---TTAG CTA------GACTAA-----------------GAAAA------------------AAAAA A---AAAA-AGACTC-----------------AAATAAA--------TAAAA-----TC- ---------AGA-AATGAAA--AA----------GGAGA---CATTACAACTGATACC-A CA-GAAATA--CAAAAGAT-CATAAG---------AGACTATT--ATGAA---------- -----------CAA---TTATATACCAACAA---ATTGGATAACCTAG---AAGAAAT-- GGATAAATTCCT----------AGACACA---------TAC-----AACCTACCA----- -AGACTGAATTA---TGAAGAAATAGAAAATCTGAAC----------------------- AGACC------------AA-TAATAAGTAAGGAGATTGAAT-C---------AGTAAT-- -AAAAAGTCTCCC------ATCAAAGAAAAG---CCCAGGACC--TGATGG--------- ------------CTTCACT-GCTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAAGAA-GAACTAA--TA-CCAATT----------CTTCTCAA ACTCTT----CC---AAAAAATTGAA------GAGGAG-GG-----------AATACTTC CAAACTCATTTT-----ACAAGGCC-----AGCAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAGC-------CAGAC AAG---------------------GAC---ACTACAAAAAA---AAAAAATTAC------ -------------A-GGCCAATAT---CCC----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACCA------------------AA--TT--------------CA--ACA----- --------GCACATT---------AAAAAAATCATTCA--CCATGAT------------C AAG---TGGGA-TT----------TATCCCA------------GG--GATGCAAGGATGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--TGTG ---ATACATCACAT------TAACAG----AATGAAGGACAAAAAC---CATATGA---- -TCATTTCAATA---GATGC---AGAAAAAGCATTTGACAA---AATTCAACATCCTTT- ---------------CATGA---------T---A--AA-----AACTCTCAAC---AAAT TAGGTATAGAAGGAATGT-----ACCTCAACACAATAAA--------------------- ------GGCCATATAT-GACAAA--------CCCACAGC-----------TAACAT--CA TACTCAATGGGGA-----AAA-GTTGAAAGC----TTTT---CCT----CT--AAGATCT GGAACA----AGACAAGG-ATGC--CCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TTACCACTTCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------TAG-GC------AAGAG---AAAGA --AATAAAAGGCATCCAAATTGGA---AAGGAA------GAAGTTAAA--T--------- ------TGTCTCTG-TT--T---GCAGA------TGACAT------GATCTTATATATA- -GAAAACC--CTAAAGA---CTCCACCA---------A---------------AA--AAC TGTTAGAACT---------AA--TAAATAAATTCAGTAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------CAT--- ACAAAAAT----CAGT-------------------------------------------- -----AGTATTTC--TA-TACACTAAC---------------AACAAACTAT-----CTA A------------------AAAAGAAATC-AAG----AAAACAATCCCATTTATAATAAC TACA---------------------AAAATA---------AAA------TACTTAGGAAT AAATTT--------AA--C-CAAGGAGGTG---A---AAGATCTGT---ACAC-TGAAAA CTATAAAACAT------TGATG-AAAGAAATTG-AA------------GAAG-------- ------------ACAC--AAAT--AAA----------AA--GATAT---------TCTA- --TGTTT------ATT-GATTGGAAGAATTAA---A---TTTT--------------G-- TTAAAATT-----------------------------------------TCCAT--ATTA CCC-AA--AGTGATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--T---------------------CCAATG-AC---ATTTTT ------------------------------------------CACAGAAATAG------- ----------------------AAAAAAAAAT------TCTAAAA---TTTTTATGGAAC C-------AAAAAACCCCCA---AA--ATAGCCAAAGCAATCTTGAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACA---CTACCTGACTTCAAAAT-----A TACTAC-------------------------AA---AGCTATAGT-AATCAA---AAC-A GCA--------------TGGTACTGG--CA------------T---AAAAACAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAGCCC------AG---AAATAAAT-- -CCAC----------------ACA-------TTTATAG----TCAACT--GATTTTT--- GACAAA--GGTGCCAAGAACACACACA-------------------ATGGA--GA---AA GG------------AGAATCTCTT--CAATAAATGG---------------TGTTG---- ------G-GAAAACTATAT-ATATACA---------------CATGC-AAAAAA---ATA ---------AAATTAGACCTT---TATTT-----------CACAC---AAA------ATA AAAAATTAACT-CAAAATGG---AT---TAAAGAC---TTAAATGTA--AGACCTGAAAC TAT------------------------AAAACTACTAGAA---------------GAAAA ---CATA-------------------------GGGGAAAAGCTCCATGACATTG--GTC- -----TGGGCAATGATT-----TTTTGGATAT-GACCCCA---AAAGCACAGGCAAA--- --AAAAGCA---AA----AAT---AGACAAA-TGGGAT----------TACATC-AA--- ACTAAAAA-----G------------CTT-CTGCA-------CA--------------GC -AAAGGAAACAAT-------------CAACAGAGTGAAGAG------------------- ------A-------------CAACCT------AAGAAA--T-GGGAG---AAAATATTT- --GCAAACCATACAT--------CT-------GATAAGGGGT--------TA--ATATC- ---CAAAATATATAAG-GA--ACTCAA---ACA------AC--TCAAT------------ ---AGC--------------AAAAAAACA---AAT--AACCTAA-TTAA---AAAATGGG C--AAA---------AGA--CCTGA---AT---AGACATTT------------------- -----TTCAAAAGAA--------GACATAC---AA-ATGGCCAAC--AGGTATATGAAAA AAT----------GCTCAACATCACTA-ATCATCA------------------------- -----GGGA-AATGCAAA-----------------TT-AAAACCACA-------AT---- ----GA---GATATCA---------CCTC----ACACCTGTTAGAATGGCTATTAT---C A--AAAAG-------ACAAAAG-----ATAACA-AATGTTT------------------- ------TGGA-GAGGATGGG----------GAAAA------------------------- ------------AAGAAAACTTTTAA-ACACTTTGGG--GGGA----------------- ----------AATGTAAA-------------AATT---AGTAC----AGCCATTATGA-- ------AAAAAAGTA--TGAAG----TTTCTT--AAAAAATTAAAA--ATAGAACTACC- -ATAT---GA--TCCAGCAATCCCA---------------------CTACTGGG-TATA- --------------TT-TTCAAAAGAA-----------ATTAAAATCA----G------- --------------TATTTTGA--AAAGATATATCC---------GCTCT----CATGTT TATTGCGCAATATTTTACAAAA-TAGCAAATATAT--G--GA--ATCA--ACCTAA---G TGTCCATCA---ATAGATG-----AATGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAT----ACACAATGGAATAC-----T--ATTCA GCCATAA----AA----------------------AAGAAGAAAATCCTGTCATTT---- ------------------------------------------------------------ --------GCAACAACATGGATGAAC-C---TGGAGGACATTATGTTAAGTGA------- ------------------------------------------------AATAAGCCAGGC ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAG---------------------------------ACAAATAC-TA-------- ---CAT---GATCTCACTTAT----------ATATGGAAATC------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TAAAA-------AGTTGAA---------------CTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------GAAGCAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GTAGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----GGTGGTT-----------------------------------------------A CCA-------GGGGCTGGGG-------------------GGGGGGGGGGTTGGGGAGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TGTTGGTCAAAGGATA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAAAATTTCAGTTAGACA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GGAGGAATAAG------------------------------ ---------------TTCAAGAGATCTATTGTACA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACATGGT-GACTATAG------------------------------------------- -----------------------------------------TTTAACAAT---------- -----------------GTATTGTATTCTTGAAAATTGCTAAGAGAGTAGATTTTAGTGT TCTCACCACAAA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAAGATAAGTATGTGAGGTAATGCATATGTTAATTA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GCTTGATTTAGCCATTCCACAATGTATACATATTTCAAAACA--TCAT GTTGTACACCATAAATATATACAATTTTTATTTGTCAATTAAAAA--------------- ------ >L1MA7 ------------------------------------------------------------ ------------------------------------------------------------ ---TCCACTGCTCCTGATTCCAGGCCA--------------GTGCCCATGGAGGAAGAAT TCAGACCTG-------------------------------CCCCAGGCCAGA-------- ----------------------------------CGGAAATCTGCTACCCTATCAG---- -GAGAAACCTGAGTACAAGTCCCCTTTAACAACAGCTGACTGA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------AGTGGCCTTGGGCCCCGCCCTGAA------TAAATTTCAGT-------GGTAGC CAAGCTATAGCAATCATGGT---CCTTGGGTAAA---------C-CCCAGTGATGCACTG TTCTGGGAGGCTGT----------GGGCTTGTGGTATGACCCAGAGTGATACCAGCTGTG GAG-------------------------------------GTCATGGGAGTGCTCTTGTC ACCTCTTCCCCAACACCAGGCAGTGCAGTGTGGA-----GA---CAGAATCCTTCT---- ----------------------------------------------------ACTCTGAA TAAGGAGAGGAAAAAGTAGAAGGGACCAGCCCCGCCCACCACAGAACAATGCA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCCAACCAAATCC----TGGGGCTATCCT TAGCCACATAGCCGACCCAGTGTCATGTCCCTAGAAGTGACTTTCCTCTGACGGGAAATT TTGACTCAGTTAAGAG-------------------------------------------- -----------------------------------------------------------C CAGCCGCTGCTCAGCTTATTAAACAAACAGCC-------------GTCCTATGCTGCCGA AAACCCTAATCCAGTGGCCCAGCCTGT--------------------------------- ------------------------------------------------------------ ---------------------CAGGGTGGAAATCTTTCAAG------------------- ------------------------------------------------------------ ----CCT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------TGTTTGCAAACAGGCC-- ---------TGGCCTGTGTTGTTACGTGCCCAAGTGGTCACC------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TCTCCCAGCC-------TCAGAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CTAAGG----CCGTCAGCCTT GTCCA-ACTTTAGATCCCAAATAGCTGAATAGCCC------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AGCAAGGGAATACATCTTCTGCCCAGTCTGACCAG AGGCAATTGCAGAA--------------------------------TCCAGTCAGCAACT TT---------------------------------------------------------- ------------------------------------------------------------ --------------------------------GCCTAATAGAAGACCCCAGCCAGCGATC TCGCTGGACCTCAGAGCACAGCCAGCTGTCC----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------CATGAGACA-----------CCGGATCAAAGGTAGCA GCCC-------------------------------------------------------- ----------------------------AGCCCAAACTAAAGAAATG------------- --A-----------CAACAATGTCTACATGTCTGGGGTTA-------------------- ----------------------------------------------TTACCAGCTAGCCC ACCCAGAATCACAGGCAAGACTAAATAGTGAAGATCT--ATCCCCACAAAA--------- ---------GAACACTAG------------------------------------------ -GAAGGCTA-------------------GAAGAGGGAGCCTGTTTCTTAAAG-------- ------------------------------------------------------------ -------------------------------TTCAAAGATA-----CCAGTATGAGAC-- --------------------------------------ATAATAACAAA--------GAA GTAAAGAAGAATAAGA-------------CAAT--CCTGACAAAGTTACAAG-------- -------AAT----GCAATAAAGT-------------------TC-CAA---TAATCGAC CTCAAAG----------------GAA---GGAAGATTTATGAATTCACTGAAAA------ ------AGAA------------TTCTAAAAAATTCT-TTTAATGAAGTTCAGTGAACT-- --ACAAGAAAATACA--------------------------GATAAGAAATTA-----AA TGAAATTTGGAAAACAAATCATTGACAAAATTAAAAATTTAATAAAAAAAAAAAAAACAA A-AAAAGAA--------------------------------------------------- GAAATAAG----------AAAGATAGAGAATAGAATAACA-------------------- -------------------------------------------ATGACTAAACTAAAAAA ----------ATAAATTAAAAAGTAAAGCTTAACAGCGAGCTAAA---------TTGTA- GATA----TAAAA---------AATAA---AATAACTGAAATGAAAAATTCAATAGAA-- ---AGGTTTAACAGCAGA----------------ATTG--------------------AT C--AAGC------------------AGAAGAAAA-GAT-CAGTG--AACTTAAAAAA--- -AGGAAATTTAAAA-T-----TATCAAATTAG---------AAGAAAAAAAA---AAAAA AAAA---ATAAAAAAA-AA---------AAA---AAACAGCCTAA--GGAAATTATGGG- ACACC--------A---TCAAACG--GACTAATCTATGC--A-TAATTGG--AGTT---- ----------CTAAAAG---AAAAAGAGAAAAAA---AAAGGAACAG---------AAAG TATATTT---AA-----AGAAATAATGACT--GAAAACTTCCCAAATCT----------- ---------GGGGAAAGATAT--AAAC--ATTCAGATAC-----AGGAAGCTCAAAAG-A TTTCAAATA------------AAATTAA-TCC--------------AAAAA---AGACTC A-------A---------------------AGACATATCATAATCAAATT-------TCA AAAAATCAAAG---AAAAAA--AAAAAATTT----------------------------- -------------TGAAAAC--AGCAAAAGA---AAAAAAACACAT-------------- -----------CAC---ATACAAGGG-AACCCCAA--------------TAAATTT--GT CAGCAGAATTT-----TTAGAAAAAAAATCT---AAGGC------CAGAGGGAAGATG-- -----------GAAGTAATATA-T-------AAAAAAATTAAT-------------GAAA AAAAA---------------AAA-TT--TCC--ACACAAAA--------TTT---TGTAT ACA-----------GACAAAATATGC-----TTTAC-AAAAGA-------AG-------- ------------------------G-AGAAATAAAAAATTTTTCAAACCAAAAAAAGGTT AAGGGA-TTTTATAACAACCAACC---CTGCTTAA--AAGAA------------------ --------------------ATGCTAAAAAG----------------------------- -----------------------------------AGTTCTTTATAGGGATAATTTAAAC AGA---------------------------------AACAACCAAACTTAAGCTGAAACA AAAGGCTGCTAATTAATAACATAAAAAAAAATAAAAATCTAAAATTC------------- -------------------------------ACAATTAAATAAGT--------------- ------------------------------------AATACAT----------------- --------AGTCATATTCAGAATACTCTAATACTGTAA---------------------- ------------------------------------------------------------ ---------------------------------------TGGTGGTGTG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TAAAGCAATTTTATCCCTAGTATGAGGGTTAAAAGACAAAACTATTAA AAACAACTAT-------------------------------------------------- ------------------AGCTACAATAAATTGTTATGAAATAAAAAAATATAAA----- --------------------TTATGAAAATAGTGACATCAAAATCATAAAAGGTGGAGGG GGGGGAAAAAAGAGTGAAGGT--------------------------------------- ------------------------------------------------------------ ----------TTTG---TATGTAATCAAAGTTAAGTTGTTATCAGCTTAA---------- --------AATA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GC-------- --------------------CTGTTTTAAG-------------------------TATAA GATGTTTTATGTAAGCCTCATG----------------------------GTAACCACAA AGCAAAAACC-TATAGTAGATACACA---------------------------------- ---------------------AAAAATAAAAA---------------------------- ------------------------------------------------------------ --------------------------------------------------GAAAGGAATC AAAGCATACCACTACA-GAAAACCATCAAACCACAAAGGAAGACAGCAAGAAAGGAAGAA AGAAA------------------------------------------------------- ---------------------CAAAAGATCTACA--------------AA---ACAACCA GAAAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------CAATTAA----------------------- ------------------------------------------------------------ --------------------CAAAACCTA--TCAATAATTAC-CTTGAAT-------G-T AAAT--GGATT--AAATTC---TCCAATA----------------AAAAGAC------AT AGAA--TGACTG----AATG---------GATTAT----AAAA---AAAAAAAACCAAA- ---CTA-------TAG-CTTGTTTA-AAAGAAACTCACTT-TACTT--TTAAAGACACAC A-TAGACTGAAAGTGAAGGGA---T------------GGAAA----A-AAATATTTCATG C--------------AAATAG------AAACC---------------------AAAAA-A GAGCAG--GGGT----AGCTATACTTATATC-AGACAAAATAGACTTTAAG-TC------ ----AAAAACTG---TAAAAAGAGAC-AAAG-AAGGTCAT------TATAT------AAT GATAAA---AGGGTCAATT------CATCAA---GAGG--------AT-ATAACAA-TTG TAA-----------------A----TATATATG---------CACCCAACATTGGAGCAC CTAA--ATA-TATAAAGCAAATATTAAAAGATCT--GA----AGGGAGA---------GA TAGACTGCAAT------ACAATAATAGTAGGGGACTTCAATA----------------CC CCACT------TTCAAC-AATGGACAGATCAT---------------------CCAGAC- -----AGAA-------------AATTAATAAGGAAACATTGGACTTGAAC-TACACTTTA GA------CCAAATGG---ACCTAACAGATATATACA--GA----ACATTCCATCCAACA GC---AACAGAATACACAT------TCTTCTCAAGTA-----CA--CAT-GGAACATTCT --C----CAGGATAGATCATATGTTAGGCCACAAAACAAG-------------------- -TCTTAACAAATTTAAGAAGA--TTGAAAT----------------CATATCAA------ -GTATCTTTTCT---AACCACAATGGTA-TAAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------GG --------------AGA-AATTTTGG---AAAATTCACAA----ATATATGGAAA--T-T AAACAACATG-CTCCTGAA---CA-ACCAATG--GGTCAAAGAAGA--AAT--A-AAAAG GAAAATT---------------AAAAAATATCTT---GAGAC------------------ ------AAATAAAAATGA-AAA------------CAAAAA--ATACCAAAAATTAATGG- AA-----TGCAGCAAAAGCAGTT-----------------------------CTAAAAGG AAAA--TTTAAAGCAATA----AATAT-------CAAAAAAAAG----AAGAAAGATCT- --CAAATAAAC-AACCTAA-TATTACACCTC---AAGGAAC--TAGAAAAAA------AA GA-----ACAAACTAAGC-------------CCAAAGT--TAGCAGAA-GGAAGGAAATA ATA---AAGATCAGA-------------------GCAGAAATA---AA-T-GAAATAGAG ACTAG------AA------------------------------------AAA-CAA---T AAAAAAAATC-A---------ATA----AAACTA-AGAGTTG------GTTTTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATTGACAAACCT---TTAG CTA------GACTAA--GAA------------AAAAA----------------------- ----GAAA-AAAAAC-----------------AAATAAA--------TAAAA-----TC- ---------AGA-AATGAAA--GA----------GGAGA---CATTACAACTGATACC-A CA-GAAATA--CAAAGGAT-CATAAG---------AGACTACT--ATGAA---------- -----------CAA---TTATATGCCAACAA---ATTGGATAACCTAG---AAGAAAT-- GGATAAATTCCT----------AGACACA---------TAC-----AACCTACCA----- -AGACTGAATCA---TGAAGAAATAGAAAATCTGAAC----------------------- AGACC------------AA-TAATGAGTAAGGAGATTGAAT-C---------AGTAAT-- -AAAAAGTCTCCC------ATCAAAGAAAAG---CCCAGGACC--TGATGG--------- ------------CTTCACT-GCTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAAGAA-GAACTAA--TA-CCAATC----------CTTCTCAA ACTCTT----CC---AAAAAATTGAA------AAGGAG-GG-----------AATACTTC CAAACTCATTTT-----ATAAGGCC-----AGCAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAGC-------CAGAC AAG---------------------GAC---ACTACAAGAAA---AGAAAATTAC------ -------------A-GGCCAATAT---CCC----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACCA------------------AA--TT--------------CA--ACA----- --------ACACATT---------AAAAGAATCATTCA--CCATGAT------------C AAG---TGGGA-TT----------TATCCCT------------GG--GATGCAAGGATGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--TGTG ---ATACACCACAT------TAACAG----AATGAAGGACAAAAAC---CATATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTTGACAA---AATTCAACATCCTTT- ---------------CATGA---------T---A--AA-----AACTCTCAAC---AAAT TAGGTATAGAAGGAATGT-----ACCTCAACACAATAAA--------------------- ------GGCCATATAT-GACAAG--------CCCACAGC-----------TAACAT--CA TACTCAATGGTGA-----AAA-GTTGAAAGC----TTTT---CCT----CT--AAGATCA GGAACA----AGACAAGG-ATGC--CCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------TAG-GC------AAGAG---AAAGA --AATAAAAGGCATCCAAATAGGA---AAGGAA------GAAGTGAAA--T--------- ------TGTCTCTG-TT--T---GCTGA------TGACAT------GATCTTATATATA- -GAAAACC--CTAAAGA---CTCCACCA---------A---------------AA--AAC TGTTAGAACT---------AA--TAAACAAATTCAGTAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------CAT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCATTTC--TA-TACACTAAC---------------AACAAACTAT-----CTG A------------------AAAAGAAATT-AAG----AAAACAATCCCATTTACAATAGC TACA------------------AAAAAAATA---------AAA------TACTTAGGAAT AAATTT--------AA--C-CAAGGAGGTG---A---AAGATCTGT---ATAC-TGAAAA CTATAAAACAT------TGATG-AAAGAAATTG-AA------------GAAG-------- ------------ACAC--AAAT--AAA---TGGA---AA--GATAT---------CCTA- --TGTTC------ATG-GATTGGAAGAATT-A---A---TATT--------------G-- TTAAAATG-----------------------------------------TCCAT--ACTA CCC-AA--AGTAATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--T---------------------CCAATG-TC---ATTTTT ------------------------------------------CACAGAAATAG------- ----------------------AAAAAAAAAT------CCTAAAA---TTTATATGGAAC C-------ACAAAAAACCCA---AA--ATAGCCAAAGCAATCATGAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACA---CTACCTGATTTCAAAAT-----A TATTAC-------------------------AA---AGCTATAGT-AATCAA---AAC-A GCA--------------TGGTACTGG--CA------------T---AAAAATAGACA--- ---CATTAAC--CA---ATGG-AACAGAATAGAAAGCCC------AG---AAATAAAC-- -CCAC----------------ACA-------TTTATAG----TCAATT--GATTTTT--- GACAAA--GGTGCCAAAAAAAAAC--A-------------------ATGGG--AA---AA AG------------ACAGTCTCTT--CAATAAATGG---------------TGTTG---- ------G-GAAAAC--TGG-ATATCCA---------------CATGC-AGAAGA---ATG ---------AAATTGGACCCT---TATCT-----------CACACC--ATA--T---ACA AAAA-TCAATT-CAAAATGG---AT---TAAAGAC---TTAAATGTA--AGACCTGAAAC TGT------------------------AAAACTACTAGAA---------------GAAAA ---CATA------G------------------G-GGAAAAACTCCATGACATTG--GTC- -----TGGGCAATGATT-----TTTTGGATAT-GACCCCA---AAAGCACAGGCAAC--- --AAAAGCA---AA----AAT---AGACAAA-TGGGAT----------TGCATT-AA--- AATAAAAA-----G------------CTT-CTTCA-------AA--------------AC -AAAAGAAAT----------------CAACAGAGTGAAGAG------------------- ------A-------------CAACCT------ATAGAT--T-GGGAG---AAAATATTT- --GCAAACCATACAT--------CT-------GATAAGGGGT--------TA--ATATC- ---CAAAATATATAAG-GA--ACTCAA---ACA------AC--TCAAT------------ ---AGA--------------AAGAAAACA---AAT--AACCTAA-TTAA---AAAATGGG C--AAA---------AGA--CCTGA---AT---AGACATTT------------------- -----CTCAAAAGAA--------GACATAC---AA-ATGGCCAAC--AGATATATGAAAA AAT----------GCTCAACATCACTA-ATCATTA------------------------- -----GGGA-AATGCAAA-----------------TT-AAAACCACA-------AT---- ----GA---GATATCA---------CCTC----ACACCTGTTAGAATGGCTATTAT---C A--AAAAG-------ATAAAAG-----ATA----ACTG--T------------------- ------TGGC-AAGGATGTG----------GAGAA------------------------- ------------AAGGGAACCCTTGT-ACACTGTTGG--TGGA----------------- ----------AATGT--A-------------AATT---AGTAA----AACCATTTTTG-- ------AAAACTGTA--TAGAG--G-TTCCTC--AAAAAACTAAAA--ATAGAATTACC- -ATAT---GA--TCCAGCAATCCCA---------------------CTTCTGGG-TATA- --------------TA-TCCAAAAGAA------------AAAAAATCA----G------- --------------TTTTTCAA--AGAGATATCTGC---------ACCCC----CATGTT CATT--GCAGCATTATTCACAA-TAGCCAAGATAT--G--GA--ATCA--ACCTAA---G TGTCCATCA---ATAGATG-----AATGGATAAAA--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAT----ACACAATGAAATAC-----T--ATTCA ACCTTTA----AA----------------------AAGAAAGAAATTCTGTCATTT---- ------------------------------------------------------------ --------GTAACAACATGGATGAAC-C---TGGAGAACATTATGCTAAGTGA------- ------------------------------------------------AATAAGCCAGGC ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AA---------------------------------------ATAC-TG-------- ---CAT---GTTCTCACTTAT----------AAATCT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAA-------AGTTGAA---------------CTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------GAAGTAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GTAGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----GGTGGTT-----------------------------------------------A CCA-------GAGGCTGGGG---------------GGGGGGGGGGGGAGGGGGATGGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGGGGAGATG--------------- ------------------------------------------------------------ -------------------------TT--------------------------------- ---------------------------------GGTCAAAGGGTA--------------- --CAAAGTTT-------------------------------------------------- ------------------------------------------------------------ ---------------CAGTTAGACA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GGAGGAATAAG------------------------------ ---------------TTTTAGTGATCTAT------------TGCACA------------- ------------------------------------------------------------ ------------------------------------------------------------ -GCATGGT-GACTATAG------------------------------------------- -------------------------TT-----------------AATAAT---------- --------------AATGTATTGTATATTTCAAAATTGCTAAAAGAGTAGATTTCAAATG TTCTCACCACAAAA---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AATGTTAAGTATTTGAGGTGATGGATATGTTAATTA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GCTTGATTTAATCATTCCACAATGTATACATATATCAAAACA--TCAC ATTGTACCCCATAAATATATACAATTATTATTTGTCAATTAAAAATAA------------ ------ >L1MA9 ------------------------------------------------------------ ------------------------------------------------------------ ------------AATGTTAGCAAG-----------------TTGGCAAAATAAAAGTCCC CTGCCCTTT------------------------------TTCCCCCCAA----------- ---------------------------------------AGAAACACACATCTACA---- -----------------------TTTTGTCCCAAATACCTAAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------GAAGATTACGAGAACTGCAGAATACACTCGAAAAATCACAGAAATCCAAGATGG TAAAAAAGA------------------------------------CAAAAAAAGACAAAG CCTAAACTCTGCCACCCCAAGTCCCACTTTACCCACAGCTCCCCACCGCCGCAGACACCT TGG-------------------------------------CTTAGTACCGGGAGGGACCC GCTCACTCCCAGCTCCCCCCAGCGGATAGAACAG-----TT---TGCGTATCGCATCAAC CCTTACCACCACCATGAGGAATGCTGGCTTTCACGCCTGACCCCTA------CAGTCATC ACAGATAACATGAGAACAGTAGGTGTAAGTATCCTGCAGATATTTAAGAGTAGAAAAAAG AAAGATAGGCTCACAGACACCAGAGAACAGAACTTAAAATAATATGTTAAAATATTAACA TAAAATAATAATAATAATAATAAAAGAACCAAAATAATATATCAAAAGAACTTTAAAAAA GAGCCAAGAACTCCACCAAAAGATTCACTTATAAAGCTTGTCTTCTGAATCCCTCGCAGA TTTTATCCACT------------------------------------------------- -------------------------------TCCCCACGTACTC----ACAGACCATTTA GGGTTTTATTTCTTGAGAAGATTTTATTAGGGGATCGAAAGCCCAGAGTTTGCGAGAGTT CTATTTGTGCCCGCTG-------------------------------------------- -----------------------------AGCTATTACATCAGACCCAGCGAGGGCTCCG CCGTCCCTTAGTCGGACAGGTGGCCGGAGCTT-------------CTCCACCGACCGCTT GGCAGGCCGAATGCACACC--------------T----------------------GCTA ACGACTCCACCCTTT------------CTAAGTCAC---CCTAAGAGGCCAGCTTGGAAA CT-------------------CTGCCCGGACCTCGCAGCGG------------------- ------------------------------------------------------------ ----CCAACAAT------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------CGTTGCCCT-- ---------AGAGGTGTGAGAGACGGAGCACTGTTGTGGCAGACGTGCCATCCTAGCCTC TGCCCTCTGCAATCCGAAACCTGCCCCCCCCCTTTCCCTGCTCCACGCAGTACATCTTGG ATCACCCGCATCTGACCTTCCCTGGTGCTTCGGTTCCCCACAGTTGGGCGTTAAGTGAAC CGGATTTCGCATTGGGGATGCAGGCGCAGCTACAGTTCTCTCGGGACCCCAGCAGAGTGG TACTGGCTTCATGGACA---TCCCCTACCC-------CTCGGGAATCATTGCCCCTGCAA CCGTTTGGCGGCAAGGGTCCTGGGGCCGAGACGAGCTGGTACCGGGCACGCCGGGGGTCT GCAGTGATTGGCGAGCTGGACCCTTCAGTCCTACTGTCTGAGCAGCATCGTCGCACAATC CTCTGAGTGCGCTCGCTCCTGGGGGCCAGGGGCCCGAGAGTGCTTCCAGCCCTTGGCGTC TTAGG-GTGAGGCTGTTTTGCCCCCTCCTCCCTGCAGGAAACTAAGCTTCGACTGCTTGC CGTTCCAGCGTTGCTGCTTCCTAGGCACCGTGCCTCCCACCTCCT--------------- --------------------------------------------GGGATACACCTCTGAC CGCGCAGTCAGGGGTCTAGCCGGTTATCTGTCTGCCTCCTCCCCCCCGGGGGCAGAGCGG G-------------------------------------------GGGTCAGGACAGGCGC CCCCAGCCTTGGGGTTGGAGACTTCAGTGGCCCCCTGGCTTCCCAGCGGTGCCCGCAGCC GTCGC-----------------TGCCCCGGCGCCCCTCAGTCCCTGCCCGGGCCTTGCTG CCCCGGGTGGAGGG--------------------------------ACCGCCCACTAGCG TC------------CCGGCGCCAGACCCCGCCCCGC------------------------ -----------------------ATCCCCCAGGCCCACAGCGCATCCACCCCCCGGCACC CCTCCCCACATCCCTGCTGGCGGCTCCCGCAGGTTCTGGCCCCGCCCCCCCCTGTCACCC AGGCCCGCTCCTCGTGAGTGCCCATACAGGGGGGG----ACTGCAAGCACCCCGCACCGG CACCCTGCCTATGGATGC------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TAGACTAAAAGCCACCA CTCCTGGACCCCCCAGGCCGCGCCCCCAAGGCTATCACGGTCGTTACTGATCCTGCCCTG ACGTGAGAAGGCGGCACACAGTCTGCTGCTCTGCCCCCCCAGCGGCA------------- --A-----------TGAGACCAGTGAACCCCGCCAGCCAGCACACAAAGTCTGAGAGC-- ----------------------------------------------TCCTAAGATCCTCT CGGGATGCCGGGAGGGGGGTTTCCCTCCTGAAGCCA---GTCTGTAAAGAC--------- ---------TGGAA---------------------------------------------- ----------------------------GAGGTGACTGCTTCTTCAAA------------ ------------------------------------------------------------ -------------------------------TGCGCAGACA-----TCAATGCAAGGACA CAA-------------------------------------GAAACATGA--------AAA ACAA-----GGAAACA-------------TGAC--ACCA--CCAA---A-GG-------- -------AAC----AAAATAATTT--------------------C-CAG---TTACCAAC CCCCAAG----------------AAA---TGGAGATCTATGAATTGCCTGACAA------ ------AGAA------------TTCAAAATAATTAT--TTAAGGAAGCTCAGTGAGCT-- --ACAAGAGAACACA--------------------------GATAGACAACTC-----AA TAAAATCAGGAAAACAATACATGAACAAAATGAGAAGTTCAACAAAGAGATAGAAAATAT TAAAAAAAAAACCAAACAGAAATTCTGGAGCTGAAGAATACAATGACTGAACTAAAATAT TCAATAGAGCCGCATTCTGGAGCTGAAAAATACAATGAGTGAAATGAAAAGAGCAATAGA GAGCTTCAACAGCAGACTTGA----------------------TCAAACAGAAGAAAGAA TGTCTGAAATGGAAATTTATAAATTGCGTAAAAAGTCATTTAAAATAATGATAATAATG- GAAC----TGAAT---------AAGAC---AATAAAAGAAATAAAAAATTCATTCGAT-- ---AAAATCAACAACACA----------------ATTG--------------------AT C--AAGT------------------AGAAGAAAG-AAT-TTATG--AACTAGAAGAT--- -AGGTCATTTAAAA-T-----GACTAAGTTAA--------AGGAAAAACAAA---AAAAA AAAA---AAATAAAAAAAA---------TTA---AAAAAACCTAC--AGGACTTATGGG- ACACC--------A---TTAAGTG--AACAAAAATTCAC--ATTTATAGG--AATT---- ----------CAAGAAA----------GAAAA-----AAGGGGATAG---------AAAG CTTATTT---AA-----AGAAATAATGGCT--GAAAACTTCCCAAGTCT----------- ---------GGGAAGAGAAAT--GGAC--ATCCAGATCC-----ATGAAGCTCAAAGA-T CCCCAAATA------------GATTCAA-CCC--------------AAAGAGGTCTTCTC T-------G---------------------AGACACATTATAATCAAATT------GTC- AAAAGTCAAAG---ACAAAG--AGAAAATTT----------------------------- -------------TAAAAGC--AGCAAGAGA---AAAGCATCTAAT-------------- -----------CAC---ATATAAGGA-AATCTCCA--------------TTAGACT--AT CAGTGGATTTC-----TCAGCAGAA--ACCTTG-CAGGC------CAG-GAGAGAATG-- -----------GGA-TAATATA-T-------TCAAAG--TGCT-------------GAAA GAAAA---------------AAACTG--CCA--ACCAAGAA--------TAC---TATAC CCA-----------GCAAAGCTGTCC-----TTCAG-AAATGA-------AG-------- ------------------------G-AGAAATAAAGTCTTTCCCAGACAAGC-AAAAGCT GAGGGA-ATTCATTACCACTAGAC---CTGCCTTAC-AAGAA------------------ --------------------ATGCTTAAGGA----------------------------- -----------------------------------AGTTC-------------TTCAAGT AGA----------------------------------------------------AAACA AAAGGATGCTAATTAGCAACATGAAAACATATGAAAGTATAAAACTC------------- -------------------------------ATGGTAAAGGTA----------------- ------------------------------------AGTATAT----------------- --------AGTCAAATTCAGAATACTCTAATACTGTAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TGGTGGTGTGTAAATCACTTTTAACTCTAGTATAAAGGTTAAAAGACAAAAGTATTAA AAATAACTAT-------------------------------------------------- ------------------AGCTACAATAATTTGTTAATGGATACACAATATAAAA----- --------------------AGATGTAAATTGTGACATCAATAACATAAAATGTGGTGGG GGGGGGGGAAGTAAAAGTGTA--------------------------------------- ------------------------------------------------------------ -----GAGTTTTTG---TATGTGATTGAAGTTAAGTTGTTATCAGCTTAA---------- --------AATA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CTGTTATAAC--------------------------TTAA GATGTTTTATGTAAGCCTCATG----------------------------GTAACCACAA GGAAAAAACC-TGTAGTAGATACACAAAAGATAAAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AGAAGGAATC AAAGCATACCACTACAGAAAAATCATCAAATCACAAAGGAAGACAGCAAGAGAGGAAGAA AGGAA------------------------------------------------------- ---------------------CAAAGGAACTACA--------------AA---ACAGTCA GAAAA------------------------------------------------------- ----------------------------------------------------------CA ATTAACAAAATGGCAATAGTAAGTCCTTACCTATCAATAATTACTTTAAATGTAAATGGA TTAAATTCTCCAAC----TGGCA-------GTAGTAAGT--------------------- ------------------------------------------------------------ --------------------TCTTACCTA--TCAATAATTAC-TTTAAAT-------G-T AAAT--GGATT--AAATTC---TCCAATC----------------AAAAGAC------AT AGAG--TGGCTG----AATG---------GAT-------TAAA---AAAAAAAACCCAA- ---CTA-------TAT-GCTGCCTA-CAAGAGACTCACTT-TAGCT--TTAAGGACACAC A-TAGGCTGAAAGTGAAGGGA---T------------GGAAA----A-AAATATTTCATG C--------------AAATGG------AAACC---------------------AAAAG-A GAGCAG--GGGT----GGCTATACTTATATC-AGACAAAATAGACTTTAAG-TC------ ----AAAAACTG---TAAAAAGAGAC-AAAG-AAGGTCAT------TATAT------AAT GATAAA---GGGGTCAATT------CATCAA---GAGG--------AT-ATAACAA-TTG TAA-----------------A----TATATATG---------CACCCAACATTGGAGCAC CTAA--ATA-TATAAAGCAAATATTAACAGAACT--GA----AGGGAGA---------AA TAGACAGCAAT------ACAATAATAGTAGGGGACTTCAATA----------------CC CCACT------TTCAAC-AATGGATAGATCAT---------------------CCAGAC- -----AGAA-------------AATCAATAAGGAAACAGTGGACTTGAAC-AACACTATA GA------CCAAATGG---ACCTAACAGACATATACA--GA----ACATTCCATCCAACA GC---AGCAGAATACACAT------TCTTCTCAAGTA-----CA--CAT-AGAACATTCT --C----CAGGATAGATCATATGTTAGGCCACAAAACAAG-------------------- -TCTTAACAAATTTAAGAAGA--TTGAAAT----------------CATATCAA------ -GTATCTTTTCT---GACCACAATGGTA-TGAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------GG --------------AGG-AAAATTGG---AAAATTCACAA----ATATGTGGAAA--T-T AAACAACACA-CTCCTGAA---CA-ACCAATG--GGTCAAAAAAAA--AATAAA-AAAAA GAAAATT---------------AAAAAATATTTT---GAGAC------------------ ------AAATAAAAATGA-AAA------------CAAAAC--ATACAAAAAC----TAGG GA-----TGCAGCAAAAGCAGTT-----------------------------CTAAGAGG GAAG--TTTATAGCAATA----AATGC----CTACATTAAGAAAA---AAGAAAGATCT- --CAAATAAAC-AACCTAA-CTTTACACCTC---AAGGAAC--TAGAAAAAG------AA GA-----ACAAACTAAGC-------------CCAAAGT--TAGCAGAA-GGAAGGAAATA ATA---AAGATCAGA-------------------GCAGAAATA---AA-T-GAAATAGAG ACTAG------AA------------------------------------AAA-CAA---T AGAAAAGATC-A---------ATA----AAACTA-AGAGTTT------GTTTTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATTGACAAACCT---TTAG CTA------GACTAA-----------------GAAAA------------------AAAAA A---GAGA-AAACAC-----------------AAATAAA--------TAAAA-----TT- ---------ATA-AATGAAA--GA----------GGAGA---CATTACAACTGATACC-A CA-GAAATA--CAAAGGAT-CATAAG---------AGACTACT--ATGAA---------- -----------CAA---TTATATGCCAAAAA---ATTGGATAACCTAG---AAAAAAT-- GGATAAATTCCT----------AGAAACA---------TAC-----AACCTACCA----- -AGACTGAATCA---TGAAGAAATAGAAAATCTGAAC----------------------- AGACC------------AA-TAATAAGTAAGGAGATTGAAT-C---------AGTAAT-- -CAAAAACCTCCC------AACAAAGAAAAG---CCCAGGACC--TGATGG--------- ------------CTTCACT-GGTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAAGAA-GAATTAA--TA-CCAATC----------CTTCTCAA ACTCTT----CC---AAAAAATTGAA------GAGGAG-GA-----------AACACTTC CAAACTCATTTT-----ATAAGGCC-----AGCAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAGC-------CAGAC AAG---------------------GAC---ACTACAAGAAA---AGAAAATTAC------ -------------A-GGCCAATAT---CCC----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACCA------------------AA--TT--------------CA--ACA----- --------GCACATT---------AAAAGGATCATACA--CCATGAT------------C AAG---TGGGA-TT----------TATCCCT------------GG--GATGCAAGGATGG -T----------------------TC-AAC-----ATATAC--AAATCAATAAA--TGTG ---ATACACCACAT------TAACAG----AATGAAGGATAAAAAT---CATATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTTGACAA---AATTCAACATCCTTT- ---------------CATGA---------T---A--AA-----AACTCTCAAC---AAAT TAGGTATAGAAGGAATGT-----ACCTCAACATAATAAA--------------------- ------GGCCATATAT-GACAAG--------CCCACAGC-----------TAACAT--CA TACTCAATGGTGA-----AAA-GCTGAAAGC----TTTT---CCT----CT--AAGATCA GGAACA----AGACAAGG-ATGC--CCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------TAG-GC------AAGAA---AAAGA --AATAAAAGACATCCAAATTAGA---AAGGAA------GAAGTAAAA--T--------- ------TGTCTCTG-TT--T---GCAGA------TGACAT------GATCTTATATATA- -GAAAACC--CTAAAGA---CTCCACCA---------A---------------AA--AAC TTTTAGA------------AA--TAAATAAATTCAGTAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------CAT--- ACAAAAAT----CAGT-------------------------------------------- -----TGTATTTC--TA-TACACTAAC---------------AATGAACTAT-----CCA A------------------AAAAGAAATT-AAG----AAAACAATTCCATTTAAAATAGC AACA------------------AAAAAAATA---------AAA------TACTTAGGAAT AAATTT--------AA--C-CAAGGAGGTA---A---AAGATCTGT---ACAC-TGAAAA CTATAAAACAT------TGATG-AAAGAAATTG-AA------------GAAG-------- ------------ACAC--AAATAAAAA---TAAA---AA--GATAT---------CCTA- --TGTTC------ATG-GATTGGAAGAATT-A---A---TATT--------------G-- TTAAAATG-----------------------------------------TCCAT--ACTA CCCAAA--AGTAATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--T---------------------CCAATG-GC---ATTTTT ------------------------------------------CACAGAAATAG------- ----------------------AAAAAAAAAT------TCTAAAA---TTTATATGGAAC C-------ACAAAAGACCCC---AA--ATAGCCAAAGCAATCTTGAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACA---CTTCCTGATTTCAAAAT-----A TATTAC-------------------------AA---AGCTATAGT-AATCAA---AAC-A GTA--------------TGGTACTGG--CA------------T---AAAAACAGACA--- ---TATAGAT--CA---ATGG-AACAAAATAGAGAGCCC------AG---AAATAAAC-- -CCAC----------------ACA-------TATATGG----TCAACT--AATCTTT--- GACAAA--GGTGCCAAGAAAACACAAA-------------------ATGGG--GA---AA GG------------ATAGTCTCTT--CAATAAATGG---------------TGTTG---- ------G-GAAAAA--TGG-ATATTCA---------------CATGCAAAAAAA---AAA ---------AAATTGGACCCT---TTTCT-----------TACACC--ATA--C---ACA AAAA-TCAACT-CAAAATGG---AT---TAAAGAC---TTAAATATA--AGACCTGAAAC TAT------------------------AAAACTCCTAGAA---------------GAAAA ---CATA------G------------------G-GGAAAAGCTCCTTGACATTG--GTC- -----TTGGCAATGATT-----TTTTGGATAT-GACACCA---AAAGCACAGGCAAA--- --AAAAGCA---AA----AAT---AAAAAAA-TTGGAT----------TACATC-AA--- ACTAAAAA-----G------------CTT-CTGCA-------CA--------------GC -AAAGGAAACAAT-------------CAACAAAATGAAAAG------------------- ------G-------------CAACCT------ATAGAA--T-GGGAG---AAAATATTT- --GCAAACCATATAT--------CT-------GATAAGGGGT--------TA--ATATC- ---CAAAATATATAAG-GA--ACTCAT---ACA------AC--TCAAT------------ ---AGC--------------AAAAAAAAA---AAT--AACCTGA-TTAA---AAAATGGG C--AAA---------GGA--CCTGA---AT---AGACATTT------------------- -----TTCAAAAGAA--------GACATAC---AA-ATGGCCAAC--AGGTATATGAAAA AGT----------GCTCAACATCACTA-ATCATCA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----AA---GATATCA---------CCTC----ACACCTGTTAGAATGGCTATTAT---C A--AAAAG-------ACAAAAG-----ATAACA-AGTG--T------------------- ------TGG--GAAGAGGTG----------TGGAA------------------------- ------------AAGGGAACCCTTTTCACCTTTTTGG--TGGA----------------- ----------AATGT--A-------------AATT---GGTAC----AGCCATTATGA-- ------AAAACAGTA--TGGAG--G-TTCCTC--AAAAAATTAAAA--ATAGAACTACC- -ATAT---GA--TCCAGCAATCCCA---------------------CTTCTGGG-TATA- --------------TA-TCCAAAGGAA------------ATGAAATTA----TC------ --------------AATATCTAAAAGAGATATCTAC---------ACCCC----CATGTT CATT--GCAGCATTATTCACAA-TAGACAAGATAT--G--GA--AACA--ACCTAA---A TGTCCATCG---ATAGATG-----AATGGATAAAG--AAAA----TG------------- -----TTATATTTATATATAGGGATACTATTGAGCCTTAAAAAAGAGGGAAATCCTGTCA TTTGTGAAAACACATACAATGTGTTATATATATATACAATGGAATAT-----T--ATTTA ACTTTAA----AAAAGAAA----------------AAAAAGGAAATCCTGCCATTT---- ------------------------------------------------------------ --------GCAACAACATGGATGAAC-C---TGGAGGACATTATGCTAAGTGA------- ------------------------------------------------AATAAGCCAGAC ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAG---------------------------------ACAAATAC-TG-------- ---CAT---GATCTCACTTAT----------AAATCT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAA-------AGTTGAA---------------CTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------GAAGCAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GTAGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----GGTGGTT-----------------------------------------------G CCA-------GGGGCTGGGG-------------------GGGGGGGGAAATGGGGAGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TGTTGGTCAAAGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAAAGTTTCAGTTATA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGATGAATAAG------------------------------ ---------------TTCTGGAGATCTA------------ATGTACA------------- ------------------------------------------------------------ ------------------------------------------------------------ -GCATGGT-GACTATAG------------------------------------------- -------------------------TT-----------------AATAAT---------- --------------ACTGTATTGTATACTTGAAATTTGCTAAGAGAGTAGATCTTAAGTG TTCTCACCACACACACACACAAAAACAAATAAAAAGACAAA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAAATGGTAACTATGTGAGGTGATGGATATGTTAAT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------TAGCTTGATTGTGGTAATCATTTCACAATGTATATGTATATCAAAACA--TCAT GTTGTACACCTTAAATATATACAATTTTTATTTGTCAATTATACCTCAATAAAGCTGGAA ------ >L1MA6 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GATAAGCATGTCATCTAGAGGGTTGTGTCCAGC ATTCACCCC---------------------GCCTTTCTCCCCCAAGAAAA---------- ---------------------------------------AGAGACCAAAGCAACAA---- -ATAAACAACT------ATA---TTTCAACTGAAGTGACTGAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------GAAGAGTGCTGGGCAGCACCAGGG------GAGTGGCAAAA-------TCTGTG TGGCATAGAAGCACCGGAGATCGCAATAGAAAGG---------G-GAGAGAGACACCCTG CCTCTGCGCCACTG----------TCTCCCC-----------------------TCCCAG GAT-------------------------------------TAGCTCCGAGTCGAGGAGGG CTTCTTCTTACAG---------GAGAAAGGTAAG-----GT---GGAAGCCCCTAGTTGT CCCCCATTCCTGC---------------------------------------CACAAATA CCAGCAGTTTCTGCTAGAGGGTCCCATCCGTCCCTCCCCGACCT---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------CAATCGCACTGGGGCCATTG----CTTGAGGTATCT GCACTGTCTTGCTCTACGGGTAGGGGCCCATCTTTAGTCCCCCCCACTCCTGTGACCTAA GCTGCTATGGCA------------------------------------------------ -------------------------------------------CAGCACCATCTTGAACC CAGACCCACTGCTAGAGCATGGTAGACGCTAA-------------GGGCGCGTCTCCAAT GATTCTCTCCTTGCCACAGCCCCTAGCCCAACTG----------------------TCCC TGGATGACATTACCT------------TCACAAGAG---CTACGGATCCCTGAACACATA AGCGAGGCCCTGAAGCCCCCTTGGAATACAAAGATGAGCAA------------------- ------------------------------------------------------------ ----ATC----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------CGTGCCTGGACCCTAGTGGGACTGG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TTCCCTATCT-------CTATGATACTGCTGCCCCCGGGC CACAAGGCTACCTAGTCCGCATGCC----------------------------------- --------------------CCCCCGGACCTAGGG------------------------- -TTTTGCACCCCAGAACAATGACCAGAGAGACAGTCATTTTGCCTCACCACCCTCCTGCG TGTCG-CGCCTGACAGCCGGCTGCCCCAGCCCCCC------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------AGCGCCAGCATGACCACACTTACAGCCAG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GCCCCCTCAGTGCCCCGCCAG GCCCAGAGAGGGGA--------------------------------GTTGGTTCGCGAC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ACTTCCAGTGTACAACACTGGACCGGGT----CTCTACCCATGCCCAA----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GGAGACATG-----------CCACAACAGAGAGGTTC CTTCCGGTCTCCCCGATGCAGGCAGCCTGGGCCACTGACGTGTCC--------------- --------------------------------------GCCTTGACC------------- --A-----------CCTATGTGGGTCTCCCCCACAGCACCTGCACTGC------------ ----------------------------------------------CCCCGCACCACCCA TTGCATTCTTGGCCTGAGCCATCGCGCCTGTTTTGAC--CGGCTCCCCAGG--------- ---------CTCAGTTGCTAGGAAAAGGTTTTCTCTTATAAATTTTGAAACAAGTCCCCA GAAGGATGGGCACAAACAAAGCCAGACTGCAAAGACTGAAATAAATACCTAACTCTTCAA ------------------------------------------------------------ -------------------------------TGCGCAGACA-----TCGATGTACATTCA CAA-------------------------------------GCATTAAGA--------ACA ATCA----GGGAAATA-------------TGAC--CTCA--CCAA---A-TG-------- -------GAC----AAAACAAGGC-------------------GC-CAG---TGACCGAC CCTAAAG----------------AGA---TGGAGATGTATGATCTGTCAGACAA------ ------GGAA------------TTCAAAATAGCTGT-TTTAAGGAAGCTCAGTGAACT-- --TCAAGAAAACACA--------------------------GAGAAACAATTC------- AGAAATT--------------------------------------------------TAT C-AGAAAAA--------------------------------------------------T TTAACAGA----------GAGATTGAAATATTAAACA----------------------- -------------------------------------------AAAAAAAAAATAAAAAA ----------ATAT---------------ATAAAAA------AATCAAACAAAATCTTG- GAGT----TGAAA---------AATTC---AATAAATGAATTAAAAAATACAATTGAC-- ---AGTGTCAATAACAAA----------------TCTG--------------------AT CTTAAAC------------------AAAAGAAAGAAAT-TTTTG--AACTTGAAGAC--- -AGGTAAGTTGAAATATTAATAATCCAGAGGG------------GTAAAAAA---GATTT AAGA---ATAAAAAGG-AA---------TAA---AGAAAGCCTAC--AGGACTCATGGG- ACACA--------A---TTAAGCA--AACAAATATTTGC--A-TTATAAG--GATG---- ----------CCAGAGG---GGGAAGAGATGAAG---AAAGGCACAG---------AAAA CTTATTT---AA-----CAAAATAATAGCT--GAAAACTTTCCAAGTAT----------- ---------TGAGAGAGATAT--GGAC--ATCCAGATCC-----AGGAAGCTCAAAGA-T TCCCAATTA------------GATTCAA-CCC--------------AAAAAGATTCTCTC C-------A---------------------AGGCACATTATAATCAAACT------GTC- AAAAGTCAAAG---ACAAAA--AGAGAATTC----------------------------- -------------TAAAAGC--TGCAAGAGA---AAAGCATCAAGT-------------- -----------TAC---ATATAAGAG-AATCTCTA--------------TTAGACT--AT CAGCAGATTTT-----TTAACAGAA--ATCTTG-CAAGC------CAG-GAAAGAATG-- -----------GGA-TGATATA-T-------TCAAAG--TGCT-------------GAAA GAAAA---------------AAAAAC--TCA--AACAAGAA--------TAT---TATAT CCA-----------GCAAAGCTATCT-----TTTAA-AAATGA-------AG-------- ------------------------G-AGAAATAAAGACCTTCGCAGACAAGC-AAAAACT GAGGGA-ATTCATCACCACTATGC---TGGCCTTAC-AAGAA------------------ --------------------ATGCTTAAAGG----------------------------- -----------------------------------AGTGC--------------TACAAC TGG-------------------------------------AAGTGCTAATGTGTAACAAG AAAACATCTGAAGGTATAAAAC-------------------------------------- -------------------------------TCACTGAAAGTA----------------- ------------------------------------AGTATAC----------------- --------AAACAAATTCAGAATACTCTAATACTGTAA---------------------- ------------------------------------------------------------ ---------------------------------------TTGTGGTGTG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TAAACCACTTATATCTTTAGTATGAAGACTAAAAGACAAAACTATTAA AAATAATAAT-------------------------------------------------- ------------------AACTACAATAATTTGTTAAGAGATAGGCTATAAAA------- --------------------AGATGTAAATTGGAAATTCAAAAATTCAAAATGTGGGGGG AAGGGAAGGTAAATGAAGGTG--------------------------------------- ------------------------------------------------TTTTTTTTTTTT TTTTTTTTGTTTTT---TTTGTGATCAAAGTTAAGTTGTTATCAGCTTAA---------- --------AATA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AC-------- --------------------CTGTTATAAC-------------------------TATAA GAGTTTTTTGTAAGCCTCATG-----------------------------GTAACCACAA AGCAAAAATC-TATAATAGATACACT---------------------------------- ---------------------AAAAATAAAAA---------------------------- ------------------------------------------------------------ --------------------------------------------------GCAAGGAATC AAAACATACTACTAGA-GAAAATCACTTAACCACAAAGGAAGACAGTAAGAGAGGAAGAA AGAA-------------------------------------------------------- ---------------------GAAAGAATCTACA--------------AA---ACAACTA GAAAA------------------------------------------------------- ------------------------------------------------------------ -------------CAA----------GTAACAAA-------------------------- ------------------TGGCA-------GTAGTAAGT--------------------- ------------------------------------------------------------ --------------------CCTTACCTA--TCAATAATTAC-CTTGAAT-------G-T AAAT--GGATT--AAATTC---TCCAATT----------------AAAAGAC------AT AGAG--TGGCTA----AATG---------GAT-------AAAA---AAAAAAGACCCAA- ---CTA-------TAT-GCTGCCTA-CAAGAGACTCACTT-CACCT--GTAAAGACACAC A-TAGACTGAAAGTGAAAGGA---A------------GGAAA----A-AAAAATTTCATT G--------------AAAAGG------AAAAC---------------------AAAAA-A AAGCAG--GAGT----AGCTATACTTATATC-AGATAAAATAGACTTTAAG--------- ---------------TCAAAAAATGAAAAAA-AAGGCCAT------TATAT------AAT AATAAA---GGGATCAATT------CAGCAA---GAGG--------AT-ATAACAA-TTA TAA-----------------A----TATATATG---------CACCCAACATTGGAGCAC CTAA--ATA-TATAAAGCAAATATTAATAGATCT--AA----AGGGAGA----------- ----CTGCAAT------ACAATAATAGTAGGGGACTTCAACA----------------CC CCACT------TTCAAC-AATGGACAGATCAT---------------------CCAGAC- -----AGAA-------------AATCAACAAAAAAAAAATAGAATTAAAA---------- ------------ATGG---ACCTAACAGACATTTATA--GA----AAATTCCATCCAACA AC---TATAGAATATACAT------TCTTCTCAACTG-----CA--CAT-GGAACATTCT --C----CAGGATAGATCATATGTTAGGCCACAAAACAAG-------------------- -TCTTAACAAATTTAAAAAAA--TCAAAAT----------------CATATCAA------ -GTATCTTTTCT---GACCACAATGGAA-TAAAACTAGAAATTAAT-------------- ----------------------------------------------AACA--------AG --------------AAA-AACTTTGG---AAACTTTACAA----ATACATGGAAA--T-T AAACAACATG-CTCCTGAA---CA-ACCAATG--GGTCAATAAAGA--AAT----TAAAA GGAAATTA--------------AAAAAATTTTTT---AAGAC------------------ ------AAATAAAAATGGAAAA------------CACACA--ATACCAAAACCTA-TGG- GA-----TACAGCAAAAGCAGTT-----------------------------CTAAGAGG GAAG--TTTATAGAAATA----AATAC----CTAAATAAAAAAAA---AAAAAAAATTA- ------TAAAC-AACCTAA-CAATGCACCTT---AAAGAAC--TAAAAAAAA------AA AA-----AAAAACTAAAC-------------CCAAAAT--TAGTAGAA-GAAAAGAAATA ATA---AAGATCAGA-------------------GCAGAAATA---AA-T-AAAATAGAG ACTAA------AA------------------------------------AAA-------A AAAAAAAAAA-A---------AAA----AAAAAA-AGAGTTT------GTTTTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATTGACAAACCT---TTAG CTA------GACTAA-----------------GAAAA------------------AAAAG A---GAGA-AGACTC-----------------AAATAAA--------TAAAA-----TC- ---------AGA-GATGAAA--AA----------GGAGA---CATTACAACTGATACC-A CA-GAAATA--CAAAGGAT-CATAAG---------AGACTATT--ATGAA---------- -----------CAA---CTATATGCCAACAA---ATTGGAAAACCTAG---AAGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----AACCTACCA----- -AGATTGAATCA---TGAAGAAATAGAAAATCTGAAC----------------------- AGACC------------AA-TAATGAGTAATGAAATTGAAT-C---------AGTAAT-- -AAAAAGTCTCCC------ATCAAAGAAAAG---CCCAGGACC--TGATGG--------- ------------CTTCACT-GCTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAAGAA-GAACTAA--TA-CCAATT----------CTTCTCAA ACTATT----CC---AAAAAATTGAA------GAGGAG-GG-----------AATTCTTC CAAACTCATTCT-----ATGAGGCC-----AGCAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGAC AAG---------------------GAC---ACAACAAAAAA---AGAAAACTAC------ -------------A-GGCCAATAT---CCC----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGCAAAAATT------------------AAATTA--------------AA--ACA----- --------GCACATT---------AAAAAGATCATTCA--CCATGAT------------C AAG---TGGGA-TT----------CATCCCA------------GG--GATGCAAGGATGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--TGTG ---ATACATCACAT------TAACAG----AATGAAGGACAAAAAC---CATATGA---- -TCATTTCAATA---GATGC---AGAAAAAGCATTTGATAA---AATTCAACATCCCTT- ---------------CATGA---------T---A--AA-----AACTCTCAAC---AAAT TAGGTATAGAAGGAATAT-----ACCTCAACACAATAAA--------------------- ------GGCCATATAT-GACAAA--------CCCACAGC-----------TAACAT--CA TACTGAATGGGGA-----AAA-GTTGAAAGC----TTTT---CCT----CT--AAGATCT GGAACA----AGACAAGG-ATGC--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------TAG-GC------AAGAG---AAAGA --AATAAAAGGCATCCAAATTGGA---AAGGAG------GAAGTCAAA--T--------- ------TGTCCCTG-TT--T---GCAGA------TGACAT------GATCTTATATATA- -GAAAACC--CTAAAGA---CTCCACCA---------A---------------AA--AAC TGTTAGAACT---------AA--TAAACAAATTCAGTAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------CAT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCATTTC--TA-TATGCTAAT---------------AGTGAACTAT-----CTG A------------------AAAAGAAATC-AAA----AAAACAATTCCATTTAAAATTGC C---------------------AAAAAAATA---------AAA------TACCTAGGAAT AAATTT--------AA--C-CAAGGAGGTG---A---AAGATCTCT---ACAA-TGAAAA CTATAAAACAT------TGATG-AAAGAAATTG-AA------------GAGA-------- ------------ACAC--AAAT--AAA---TGGA---AA--AATAT---------ATCA- --TGTTT------ATA-TATTGGAAAAATT-A---A---TATT--------------G-- TTAAAATG-----------------------------------------TCCAT--ACTA CCC-AA--AGTAATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--A---------------------CCAATG-AC---ATTCTT ------------------------------------------CACAGAAATAG------- ----------------------AAAAAAAAAT------CCTAAAA---TTTTTATGGAAA C-------ACAAAAGACCCC---AA--ATAGCCAAAGCAATCTTGAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACA---CTACCTGACTTCAAAAT-----A TACTAC-------------------------AA---AGCTATAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--CA------------T---AAAAACAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAT-- -CCAT----------------ACA-------TTTACAG----CCAACT--GATTTTT--- AACAAA--GGTGCCAAGAACACAC--A-------------------TTGGG--GA---AA AA------------ACAGTCTCTT--TAATAAATGG---------------TGCTG---- ------G-GAAAAT--TGG-ATATCTA---------------AAAGC-AAAAAA---ATA ---------AAACTAGACCCC---TATCT-----------CTCACC--ATA--T---ACA AAAA-TCAACT-CAAAATGG---AT---TAAAGAC---TTAAATGTA--AGACCCAAAAC TAT------------------------GAAACTACTAGAA---------------GAAAA ---CATA------G------------------G-GGAAATGCTTCATGACATTG--GTC- -----TGGGCAAGGATT-----TTTTGAATAA-AACCTCA---AAAGCACAGGCAAC--- --AAAAGCA---AA----AAT---AGACAAA-TGGGAT----------TACATC-AA--- ACTAAAAA-----G------------CTT-CTGCA-------CA--------------GC -AAAGGAAACAAT-------------CAACAGAGTGAAGAG------------------- ------A-------------CAACCT------ACAGAA--T-GGGAG---AAAATATTT- --GCAAACTATACAT--------CT-------GACAAGGGGT--------TA--ATATC- ---CAGAATATATAAG-GA--ACTCAA---ACA------AC--TCAAA------------ ---AAA------AA------AA--AAATA---AAA--AATATAA-TTAA---AAAATGGG C--AAA---------AGA--CCTGA---AT---AGACATTT------------------- -----CTCAAAAGAA--------GACATAC---AA-ATGGCCAAC--AGGTATATGAAAA AAT----------GCTCAACATCACTA-ATCATCA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATATCA---------CCTC----ACCCCAGTTAGAATGGCTATTAT---C A--AAAAA-----------AAA-----AAAACA-AATG--T------------------- ------TGGT-GAGGATATA----------GAGAA------------------------- ------------AAGGGAACACTTAT-ACACTGTTGA--TGGG----------------- ----------AATGT--A-------------AATT---AGTAC----AACCATTAAGG-- ------AAAACAGTA--TGGAG--G-TTCCTC--AAAAAATTAAAA--ATAGAACTACC- -ATAT---GA--TCCAGCAATCCCA---------------------CTACTGGG-TATA- --------------TA-TCCAAAGGAA--------------------------------- ---------------------ATGAAAGCAATCTGC---------ACTCC----CATGTT TATT--GCAGCACTATTCACAA-TAGCCAAGATAT--G--GA--ATCA--ACCTAA---G TGTCCATCA---ATGGATG-----AATGGATAAAA-AAAAA----TG------------- ------TGTA-------------------------------------------------- ------------------------TATAT----ACACAATGGAATAC-----T--ATTCA GACATAA----AA----------------------AAAAATGAAATCCTGTCATTT---- ------------------------------------------------------------ --------GTAACAACATGGATGAAC-C---TGGAGGACATTATGTTAAGTGA------- ------------------------------------------------AATAAGCCAGGC ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAG---------------------------------ACAAATAC-TG-------- ---CAT---GATCTCACTCAT----------ATGTGGAAAT---CT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAA-------AGTTGAT---------------CTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------GAAGTAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GTAGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGTGGTT-----------------------------------------------A CCA-------GAGGCTGGGG-------AGGGGAGGGGGGAAGGGGGGATGGGGAGAGG-- -------------------------------------------------TT--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------GGTCAATGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAAAGTTACAGTTAGATA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GGAGGAATAAG------------------------------ ---------------TTCTGGTGTTCTAT------------TGCACA------------- ------------------------------------------------------------ ------------------------------------------------------------ -GTAGGGT-GACTATAG------------------------------------------- -------------------------TT-----------------AACAAT---------- --------------AATGTATTGTATATTTCAAAATAGCTAGAAGAGAGGATTTTGAATG TTCTCACCACAAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAAATGATAAATGTTTGAGGTGATGGATATGCTAAT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TACCCTGATTTGATCATTACACAATGTATACATGTATTAAAACA--TCAC ATTGTACCCCAT-AATATGTACAATTATTATGTGTCAATTAAAAATAA------------ ------ >L1MA4 ------------------------------------------------------------ ------------------------------------------------------------ -------GTACCTCTATTTCCAAA-----------------ATGGCAGCGTAGAAGCAAT CTGGCTTCC----------CTTCCCACCATCATTGACCGCCCCCCCGCCCCC-------- ----------------------------------CCCAGGAAAGCAAAAACAGGTA---- -CACAGCGGCAACATTATCACCAGTGCTGCCCCAGAAGTCAAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------TCTGAGGCTGAGACAGTTCCTGGG------GTCACAGGGAA-------GC---- ----------------------------GAAAAA---------A-CAAAACCAAATGACC TCTGAACTGGTCGT----------AAGTGAC----------------------------- TCA-------------------------------------GACTTCTATATCTCTGACGC CCCTTCCCCCTAATCTGGCTGTCAGCAAGCACAT-----GG---AAAATTTCCCCCCAAC TCCCGGTTTCCC----------------------------------------------CC TTGAAAAAGGTGAGATTAAGGCGGACAACCAGCTTTCCCACC------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ATCTTGGGGTCCT----CGGCATGAGACC TGTC-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------CCTGCCTCAACCCAC GGGAAGCATCATGAGTGGCTCTAGGGAGAAAT-------------ATTCCTGA------- ------------------------------------------------------------ ------------------------------------------GGACAGCCAGAGAAAAAG GG-------------------GGGGGGTGGGACTACCATCC------------------- ------------------------------------------------------------ ----CCAGC--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CCCGGAAACT-------CTGCTCTGTAACTTGGCCACTGG AGACGCCAAATCAGAGTGGCTG-------------------------------------- --------------------TTCAGCAGCACCACA------------------------- -CTGTAGG-----------------------------------------ACACTTGTTCC ACAGG-TCCCCTGGGCACGAACACCTAGCCAGCCTTCCCA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------AACTGCCCGGCTGTCCCCTTTGG--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ATCCCCCACCATTCAGGATGG GCAGCGACTGATGG--------------------------------TTTACAAAATTATC AC------------TC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------ACA-----------TCAACAAGCTGCGCTA- ---------------------------------------CTGATGTTTGCCAGAGCCACG GCAAACCTGGGCTTAGGGTGCCATCTAGTGCTAAAAAGGAGGCACCG------------- --A-----------CCCCGCGGGAAAAAAACGCAAAAAAATCCACCCCGT---------- ----------------------------------------------ATATTAGACACA-- ---------------------------------------ATATCTATGGAA--------- ---------AGATATGCA------------------------------------------ -AAAAACAGCACCACAAAAACCCATACTGAAAAGAGTGGAATAAATACCTAATCCTTCAA ------------------------------------------------------------ -------------------------------TGCACAGATA-----TTGATGTACATCCA CAA-------------------------------------GAATCAAGA--------AGA AACA----GGGAAACA-------------TGAC--CTCC--CCAA---A-TG-------- -------GAC----AAAACAAGGA-------------------AC-CAG---TGACTGAC CCTAATG----------------AGA---TAAAGATATGTGAGCTCTCTGACAA------ ------AGAA------------TTCAAAATAGCAGT-TTTAAGGAAACTCAGTGAACT-- --CCAAGATAACACA--------------------------GAAAAGCAATTC------- AGAAATT----------------------------------------------------- ------------------------------------------------------------ -TATCAGG----------GAAATTTAACAAAGAGGTT----------------------- -------------------------------------------GAATAAAATTTAAAAAA -----------------------------TCAAACA------AAA---------TCTTG- GAAC----TGAGA---------AATAC---AATTACTGAACTGAAAAATTCATTAGAG-- ---GCTCTCAACAGCAGA----------------ATGG--------------------AT C--AAGC------------------AGAGGAAAG-AAT-CAGTG--AGCTCAAAGAC--- -AGGCTATTTGAAA-A-----TACACAGTCAG---------AAAAACAAAAAAAAAAAAA AAAAAAAATAAAAAGA-AA---------TGA---AAAAAACTTAC--AAGATATAGAAA- ATAAC--------C---TCAAAAG--ACCAAATCTAAGA--A-TTATTGG--TGTT---- ----------CAAGAGG---GAGTTGAGCAAGAG---CAAAGGGTAG---------AAAG CTTATTC---AA-----AGAAATAATAACA--GAAAACTTTCCAAAACT----------- ---------TGAGAAAGATAT--AAAT--ATCCAGGTAC-----AGGAAGGTCAGAGA-A CACCAAACA------------GATTCAA-CCC--------------AAATAAGACTACCC C-------A---------------------AGGCATATAATAATCAAACT------CTC- AAAGGTCAAGG---ACAAAG--AGAGGATTC----------------------------- -------------TAAAAAC--AGCAAGAGA---AAAAAAGCAAAT-------------- -----------AAC---ATATAAAGG-AGCTCCAA--------------TTCATCT--GG CAACAGACTTC-----TCAACAGAA--ACCATA-CAGGC------CAG-GAGAGAGTG-- -----------GAA-TGACATA-T-------TTAAAG--TGCT-------------GAAA AAAAA---------------AAACTG--CCA--TCCAAGAA--------TAC---TTTAT CCA-----------GCAAAGCTATCC-----TTCAA-ATATGA-------AG-------- ------------------------G-AGAGATAAAGTCTTTCCCAGACAAAC-AAAAGCT GAGAGA-ATTCATCACCACCAGAC---CTGTCTTAC-AAGAA------------------ --------------------ATGCTAAAGGG----------------------------- -----------------------------------AGTTC-------------TTCAATC TGA----------------------------------------------------AAAAA AAAAAAAAGTAACAACCAAAAAGAAACTATATGAAGGTGACACTAATGTGCAACAAGAAA ACATCTGAAGGTATAAAACTCA---------CTGGTAAAAGTA----------------- ------------------------------------AGTACAT---------AGACAAGG AAAAAGCAAGAAAAATCAAGAATATTCTAATACTGTAA---------------------- ------------------------------------------------------------ ---------------------------------------TTGTGGTGTG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TAAACCACTCATATCTTTAGTATGAAGACTAAAAGACAAATCTATCAA AAAAAAATAA-------------------------------------------------- -----------------TAACTACAACAACTTGTTAAGAGATAGGCAATTATAAAA---- --------------------ATATATAAATTGAGACAACAAAAAGTCAAAATGATGGTGA ACGTGGGGGGGATGGAGTTAA-----------------------------------AGTG TAGAGTTTTTTTGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCTTTTTTTTTTTTTCTTT GTTTCCATTCTAAA---TTTGTGATCAAAGATAAGTTGTCATCTCTTTAA---------- --------AATA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AC-------- --------------------TTGTTATAAC-------------------------TATAA AATTTTTTTTGTAAGCCTCATG----------------------------GTAACCACAA AGCAAAAACC-TATAATAGATACAC----------------------------------- ---------------------TAAAAATAAAA---------------------------- ------------------------------------------------------------ --------------------------------------------------ACAAGGAATT AAAACATACTACCAGA-GAAAATCACCTAACCACAAAGGAAGACAGTAAGAGAGGAAGAA AGGAA------------------------------------------------------- ---------------------GAGAGGAGTTACA--------------AA---ACAACCA GAAAA------------------------------------------------------- ------------------------------------------------------------ -------------CAA----------GTAACAAA-------------------------- ------------------TGGCA-------GTAGTAAGT--------------------- ------------------------------------------------------------ --------------------CCTTACTTA--TCAATAATAAC-ATTGAAT-------G-T AAAT--GGACT--AAATTC---TCCAATT----------------AAAAGAC------AT AGAG--TGGCTG----AATG---------GAT-------AAAA---AAAAAAAACCAAA- ---TAA-------TTT-GTTCCTTA-AAAAAAACCCCTTT-CCCTT--ATAAGAAACCCA A-TAGAATGAAAATTAAGGGG---T------------GGAAA----A-AAATATTTCATG C--------------AAATGG------AA------------------------AAAAA-A GAGCAG--GAGT----AGCTATACTTATATC-AGATAAAATAGACTTTAAG-TC------ ----AAAAACTG---TAAAAAGAGAC-AAAG-AAGGTCAT------TATAT------AAT GATAAA---GGGGTCAATT------CAGCAA---GAGG--------AT-ATAACAA-TTA TAA-----------------A----TATATATG---------CACCCAACACTGGAGCAC CCAA--ATA-TATAAAGCAAACATTAATAGATCT--AA----AGGGAGA---------GA TAGACTGCAAT------ACAATAATAGTAGGGGACTTCAACA----------------CC CCACT------TTCAGT-AATGGACAGATCAT---------------------CCAGAC- -----AGAA-------------AATCAACAAAGAAACATTGGAGTTAAAC-TACACACTA GA------CCAAATAG---GCCTAACTGACATTTACA--GA----ACATTTCATCCAACT GC---TGCAGAATACACAT------TCTTCTCATCAG-----CA--CAT-GGAACATTCT --C----CAGGATAGACCATATGTTAGGCCACAAAACAAG-------------------- -TCTCAACAAATTTAAAAAAA--TAAAAAT----------------CATATCAA------ -GTATCTTTTCT---GACCACAATGGAA-TAAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------AG --------------AGG-AACTTTGG---AAACTATACAA----ATACATGGAAA--T-T AAACAACATG-CTCCTGAA---TG-ACCAATG--GATCAATAA-----AAT----AAAAA GAAAATT---------------TAAAAATTTCTT---GAAAC------------------ ------AAATGAAAATGG-AAA------------CACAAA--ATACCAAAAACCT-TAGG GA-----AAAAACAAAAGCAGTA-----------------------------CTAAGAAG GAAG--TTTATAGCAATA----AATGC----CTACATCAAAAAAG---TAGAAAGACTT- --CAAATAAAC-AACCTAA-TGATGCACCTC---AAGGAAC--TAGAAAAGC------AA GA-----ACAAACCAAAC-------------CCAAAAT--TAGTAGAA-GAAAAGAAATA ATA---AAGATCAGA-------------------GCAGAAATA---AA-T-GAAATTGAG ACTAA------AA------------------------------------AAA-------T AAAAAAAATC-A---------ATA----AAATAA-AAAGTTG------GTTTTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATTAACAAACCT---TTAG CTA------GACTAA--CAA------------AAAAA------------------AAA-- ----GAGA-AGACCC-----------------AAATAAA--------TAAAA-----TC- ---------AGA-AATGAAA--AA----------GGAGA---CATTACAACTGATACC-A CA-GAAATA--CAAAGGAT-CATTAG---------AGACTATT--ATGAA---------- -----------CAA---CTATATGCCAACAA---ATTGGAAAACCTAG---AAGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----AACCTACCA----- -AGATTGAACCA---TGAAGAAATAGAAAACCTGAAC----------------------- AGACC------------AA-TAATGAGTAATAAGATTGAAG-C---------AGTAAT-- -AAAAAGTCTCCC------ATCAAAGAAAAG---CCCAGGACC--TGATGG--------- ------------CTTCACT-GCTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAAGAA-GAACTAA--TA-CCAATT----------CTACTCAA ACTATT----CA---AAAAAATTGAA------GAGGAG-GG-----------AATACTTC CAAACTCATTCT-----ATGAGGCC-----AGCAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGAC AAA---------------------GAC---ACAACAAAAAA------AAACTAC------ -------------A-GGCCAATAT---CAC----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACAA------------------AA--TT--------------CA--ACA----- --------ACACATT---------AAAAAGATCATTCA--CCATGAT------------C AAG---TGGGA-TT----------CATCCCA------------GG--GATGCAAGGATGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--TGTG ---ATACATCACAT------TAACAG----AATCAAGGACAAAAAC---CATATGA---- -TCATTTCAATA---GATGC---TGAAAAAGCATTTGATAA---AATTCAACATCCCTT- ---------------TATGA---------T---A--AA-----AACTCTCAAC---AAAC TGGGTATAGAAGGAACAT-----ACCTCAAAATAATAAA--------------------- ------GGCCATATAT-GACAAA--------CCCACAGC-----------TAACAT--CA TACTGAATGGGGA-----AAA-ATTGAAAGC----CTTT---CCT----CT--AAGATCT GGAACA----AGACAAGG-ATGC--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTTTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------TAG-GC------AAGAG---AAAGA --AATAAAGGGCATCCAAATTGGA---AAGGAA------GAAGTCAAA--T--------- ------TATCCTTG-TT--T---GCAGA------TGACAT------GATCTTATATTTA- -GAAAAAC--CTAAAGA---CTCCACCA---------A---------------AA--AAC TGTTAGAACT---------GA--TAAATAAATTCAGTAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------CAT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCATTTC--TA-TATACCAAC---------------AGTAAACAAT-----CTG A------------------AAAAGAAATC-AAG----AAAGCAATCCCATTTACAATAGC TACA------------------AAAAATATA---------AAA------TACCTAGGAAT AAATTT--------AA--C-CAAAGAAGTG---A---AAGATCTCT---ACAA-GGAAAA CTATAAAACAC------TGATG-AAAGAAATTG-AA------------GAGG-------- ------------ACAC--AAAA--AAA----GGA---AA--AATTT---------TCCA- -ATGTTC------ATG-GATTGGAAGAATT-A---A---TATT--------------G-- TTAAAATG-----------------------------------------TCAAT--ACTA CCC-AA--AGCAATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--A---------------------CCAATG-AC---ATTCTT ------------------------------------------CACAGAAATAG------- ---------------------AAAAAAAAAAT------CCTAAAA---TTTATATGAAAC C-------ACAAAAGACCC----AA--ATAGCCAAAGCAATCCTGAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACA---CTACCTGACTTCAAAAT-----A TACTAC-------------------------AA---AGCTATAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--CA------------T---AAAAACAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAT-- -CCAC----------------ACA-------TTTACAG----CCAACT--CATTTTT--- GACAAA--GGCGCCAAGAACATAC--A-------------------TTGGG--GA---AA GG------------ACAGTCTCTT--CAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-ATAACCA---------------ATTGC-AGAAGA---ATG ---------AAACTAGACCCC---TATCT-----------CTCACC--ATA--T---ACA AAAA-TCAAAT-CAAAATGG---AT---TAAAGAC---TTAAATCTA--AGACCTGAAAC TAT------------------------GAAACTACTAGAA---------------GAAAA ---CTTT------G------------------G-GGAAACGCTCCAGGACATTG--GTC- -----TGGGCAAAGATT-----TTTTGGGTAA-GACTTCA---AAAGCACAGGCAAC--- --AAAAGCA---AA----AAT---AGACAAA-TGGGAT----------TACATC-AA--- GCTAAAAA-----G------------CTT-CTGCA-------CA--------------GC -AAAGGAAACAAT-------------CAACAAAGTGAAGAG------------------- ------A-------------CAACCT------ACAGAA--T-GGGAG---AAAATATTT- --GCAAACTATCCAT--------CT-------GACAAGGGAT--------TA--ATAAC- ---CAGAATATATAAG-GA--ACTCAA---ACA------AC--TCAAT------------ ---AGC------AA------AA--AAAAA---AAT--AATCTAA-TTAT---AAAATGGG C--AAA---------AGA--TCTGA---AT---AGACATTT------------------- -----CTCAAAAGAA--------GACATAC---AA-ATGGCCAAC--AGGTATATGAAAA AAT----------GCTCAACATCACTA-ATCATCA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATATCA---------TCTC----ACCCCAGTTAAAATGGCTTTTAT---C A--AAAAG-------ACAAAAAAT---ATAACA-AATG--C------------------- ------TGGT-GAGGATGTG----------GAGAA------------------------- ------------AGGAGAACTCTTAT-ACACTGT-----TGGG----------------- ----------AAAGTAAA-------------AATT---GGTAC----AGCCACTATGG-- ------AAAACAGTA--TGGAG--G-TTCCTC--AAAAAATTAAAAATATAGAACTACC- -ATAT---GA--TCCAGCAATCCCA---------------------CTACTGGG-TATA- --------------TA-TCCAAAAAAA------------AGAAAAAAA----A------- --------------TATATATA--AAAGATATCTGC---------ACTCC----CATGTT TATT--GCAGCACTATTCACAA-TAGCCAAGATAT--G--GA--ATCA--ACCTAA---G TGTCCATCA---ATGGATG-----AATGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAT----ACACAATGGAATAT-----T--ATTCA GCCATAA----AA----------------------AAGAATGAAATCCTGTCATTT---- ------------------------------------------------------------ --------GCAGCAACATGGATGGAA-C---TGGAGGTCATTATGTTAAGTGA------- ------------------------------------------------AATAAGCCAGGC ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAG---------------------------------ACAAATAT-CA-------- ---CAT---GTTCTCACTCAT----------ATGTGGGCT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAA-------AGTGGAT---------------CTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GAGGTAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GTAGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----GGTGGTT-----------------------------------------------A CCA-------GAGGCTGGGA-------------------AGGGTAGGGGGGGGGAGGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------GGATGAAGAGAGG--------------- ------------------------------------------------------------ -------------------------TT--------------------------------- ---------------------------------GGTTAATGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAAAAATACAGATAGAAG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GAATAAG---------------------------------- ---------------TTCTAGTGTTTGATAGTACA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GTAGGGT-GACTATAG------------------------------------------- -------------------------TT-----------------AACAAT---------- --------------AATTTATTGTATATTTCAAAATAGCTAGAAGAGAAGAATTGGAATG TTCCCAACACAAAGA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAAGATAAATGTTTGAGGTGATGGATATCCCAATTA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CCCTGATTTGATCATTACACATTGTATGCATGTATCAAAATA--TCAC A-TGTACCCCAAAAATATGTACAACTATTATGTATCAATAAAAAAA-------------- ------ >L1MA3 ------------------------------------------------------------ ------------------------------------------------------------ ------GGGGGGAGGCAGAGCAAG-----------------ATGGCCGAATAGAAGCCTC CACCAATCA----------------------------TCCTCCCTACAGG---------- ---------------------------------------AACACCAAATTGAACAA---- ---------CTATCCACAAAAAAGCACCTTCATAAGAACCAAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AATCAGGTGAGTGATCACAGTACC TGGTTTTAACTTCATATCACTGAAAGAGGCACTG---------AAGAGGGTAGGAAAGAC AGTC-------------------------------------------------------- -------------------------------------------------TTGAATTGCCG ACGCCACCCCTCCCCCATCCCCTGGCAGTGGCCG-----CA---TGGCGTGGAGAGAGAA TCTGTGTGCTTGGGGGAGGGAGAGCG--------------------------CAGTGATT GTGGGACTTTGCATTGGAACTCAGTGCTGCCCTGTCACAGTGGAAAGCAACACTGGGCAG AACTCA---------------------------------------GCCAGTGCCCACGGA GGGAGCATTTAGACCAGCCCTAGCCAGAGGGGAATCACCCATCCCAGCGGTTGGAACCTG A----------------------------------------------------------- ------------------------------------------------------------ -------------------------------GTTCTGGCAAGCC-----TCGCCACTGCG GGCTAAAGTGCTCTGGGGTCCTAAATAAACTTGAAAGGCAGTCTAGGCCACAAGGACTGC AATTCCTGGGCAAGTC-------------------------------------------- -----------------------------------------------CTGGTGCTGTGCT GGGCTCAGAGCCAGTGGACTTGGGGGGCACATG------------ACCTAGTGAGACACC AGCCGGGGTGGCCAAGGGAGTGCTTGCGCCACCCCTC----------------------- ---------------------------CCCCAACCCCAGGCAGCACAGCTCGCAGCTCCA GGAGAGACTCCTTCCTTCTGCTTGAGGAGAGGAGAGGGAAG------------------- ------------------------------------------------------------ ----AGTAAAGAGGACTTTGTCTTGCAACTTGGAT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------ACCAGCTCAGCCACAGTAGGATAGGGCACCAGGCAGAGTCCTGAGGCCCCC ATTCCAG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GCCCTAGCTC-------CCGGACGACATTTCTAGACACAC CCTGGGCCAGAAGGGAACCTG--------------------------------------- --------------------CTGCCTTGAAGGGAAGGACCCAGTCCTGGCAGGATTCATC ACCTGCTGACTAAAGAGCCCTTGGGCCCTGAATAATCAGCAGTGGTACCCAGGCAGTACT TGCCGTGGGCCTTGGGTGAGACTCAGAGACGTGCTGGCTTCAGGTGTGACCCAGCACATT CCCAGCTGTGGTGGCTATGGGGAGAGACTCCTTCTGCTTGAGGAAAGGAGAGGGAAGAGT AAAGGGGACTTTGTCTTGCAGCTTAGGTACCAGCTTGGCCACAGTGGGGTAGAGCACCAA GCGGGCTCTTGGGGTCCCTGATTCCAGGCCTTGGCTCTTGGATGGCATTTCTGGACCTGC CCTGGGCCAGAGGGGAGCCCACTGCCCTGAAGGGAGAGTCCCAGGCCTGGCAGCATTCAC CACAAGCTGACTGAAGAGCCCTTGGGCCTTGAGTGAACATTGGTGGTAGCCAGGCAGTAC TCGCCACGGGCCTGGGGTGGTGGTGGCCACGGGGAGAGACTCCTCTGCTTGTGGAAAGGG GAGGGAAGAGTGGG---------------------------------------------- -------------AAGGACTTTGTCTTGTGGCTTGGGTGCCAGCTCAGCCACAGTAGAAT AGAGCACCAGGTAGATTCCTAAGGTTTCTGACTCCAGGCCCTGGCTCCTGGATGGCATCT CTGGACCCACCTGGGGCCAGGGGGAACTTGCCACCCTGAAGGGAAGGACACAAGCCTGGC TGGCTTTGCCACCTGCTGATTGTAGAGCCCTAGGG----CCTTGAGTGAACATAGGTGGT AGCCAGGCAGTGGTTACTGCAGGCC----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TTGGGTGAGACCCAGTG CTGTGCTGGCTTCAGGTCTGACCCAGCACAGTCCCAGTGGTGGTGGCCACAGGGGTGCTT GTGTCACCCCTCCCCCAGCTCCAGGCAGCTCAGCACAGAGAGAGACTCC----------- --ATTTGTTTGGGGGAAAGTAAGGGAAGAGAACAAGAGTCTCTGCCTGGTAATCCAGAGA ATTCTTCTGGATCTTATCCAAGACCACCAAGGTGGTACCTCTATGAGTCTGCAAGAGCCA CAGCGTTACTGGGCTTGGGGTGCCCCCTAATGCAGATATGGCTGCAGTGAC--------- ---------CAAAAAC-------------------------------------------- -TTAGATCACAACACCCAAGTCCCTTTGAATACCTGGAAAGCCTTCCCAAGAAGGA---- ------------------------------------------------------------ -------------------------------TGGGTACAAACAAGCCCAGACTGTGAAGA CTACAATAAATACCTAACTCTTCAATGCCCAGACACTGATGAACATCCACAAGCATCAAG ACCATCCAGGAAAACA-------------TGAC--CTCA--CCAA---A-TG-------- -------AAC----TAAATAAGGC-------------------AC-CAG---GGACCAAT CCTGGAG----------------AGA---CAGAGATATGTGACCTTTCAGACAG------ ------AGAA------------TTCAAAATAGCTGT-TTTGAGGAAGCTCAATGAAAT-- --TCAAGATAACACA--------------------------GAGAAGGAATTC------- AGAATCC----------------------------------------------------- ------------------------------------------------------------ -TATCAGA----------TAAATTTAACAAAGAG-------------------------- -------------------------------------------ATTGAAATAATTAAAAA ----------GAAT---------------CAAGCAA------AA----------TTCTG- GAGT----TGAAA---------AATGC---AATTGATATACTGAAGAATGCATCAGAG-- ---TCTCTTAATAGCAGA----------------ATTG--------------------AT C--AAGC------------------AGAAGAAAG-AAT-TAGTG--AGCTTGAAGAC--- -AGGCTATTTGAAAAT------ACACAGTCAG---------AGGAAACAAAA---GAAAA AAGA---ATAAAAAAG-AA---------TGA---AGCATGCCTAC--AAGATCTAGAAA- ATAGC--------C---TCAAAAG--GGCAAATCTAAGA--G-TTATTGG-----C---- ----------CTTAAAGAGGAGGTAGAGAGAGAG---ATCGGGGTAG---------AAAG TTTATTC---AA-----AGGGATAATAACA--GAGAACTTTCCAAACCT----------- ---------AGAGAAAGATAT--CAAT--ATTCAAGTAC-----AAGAAGGTTATAGA-A CACCAAGCA------------GATTTAA-CCC--------------AAAGAAGACTACCT C-------A---------------------AGACATTTAATAATCAAACT------CCC- AAAGGTCAAGG---ATAAAG--AAAGGATCC----------------------------- -------------TAAAAGC--AGCAAGAGA---AAAGAAACAAAT-------------- -----------AAC---ATACAATGG-AGCTCCAA--------------TATGTCT--GG CAGCAGACTTC-----TCAGTGGAA--ACCTTA-CAGGC------CAG-GAGAGAGTG-- -----------GCA-TGACATA-T-------TTAAAG--TGCT-------------GAAG GAAAA---------------AAACTT--TTA--TCCTAGAA--------TAG---TATAT CCA-----------GTGAAAATATCC-----TTCAA-ACATGA-------AG-------- ------------------------G-AGAAATAAAGACTTTCCCAGACAAAC-AAAAGCT GAGGGA-TTTCATCAACACCAGAC---CTGTCCTAC-AAGAA------------------ --------------------ATGCTAAAGGG----------------------------- -----------------------------------AGTTC-------------TTCAATC TGA----------------------------------------------------AAGAA AAAGGATATTAATGAGCAATAAGAAATCATCTGAAGGTAACAAAACTCA----------- -------------------------------CTGGTAATAGTA----------------- ------------------------------------AGTACAC----------------- --------AGAAAAACACAGAATATTATAACACTGTAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TTGTGGTGTGTAAACTACTCATATCTTGAGTAGAAAGACTAAAAGATGAACCTATCAA AAATAATAAC-------------------------------------------------- --------------------------------------------------TACAACAACT TTTCAAGACATAGTATAATAAGATATAAATAGAAACAACAAAAAGTTAAAAAGCGGGGGG ATGAAGTTAAAGTGTAGAGTT--------------------------------------- -------------------------------------TTTATTAGTTTTCTCTTTGCTTG TTTGTTAGTTTGTT---TATGCAATCAGTGTTAAGTTGTCATCAGTTTAA---------- --------AATAATGG-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------GT-------- -------------------------------------------------------TATAA GATATTATTTGCAAGCCTCATG----------------------------GTAACCTCAA ATCAAAAAACATACAACAGATACACAAAAAATAAAAA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GCAAGAAATT AAAACATACCACCAGAGAAAATCACCTTCACTAAAAGGAAGACAGGAAGGAAGGAAAGAA GGAAGAGAAGACCA---------------------------------------------- ---------------------CAAAACAACCAGA--------------AA---ACAAATA ACAAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------TGGCA-------GGAGTAAGT--------------------- ------------------------------------------------------------ --------------------CCTTACTTA--TCAATAATAAC-ATTGAAT-------G-T AAAT--GGACT--AAACTC---TCCAATC----------------AAAAGAC------AT AGAG--TGGCTG----AATG---------GAT-------AAAA---AAAAAAGACCCAA- ---TGA-------TCT-GTTGCCTA-CAAGAAACACACTT-CACCT--ATAAAGACACAC A-TAGACTGAAAATAAAGGGA---T------------GGAAA----A-AGATATTCCATG C--------------CAATGG------AAACC---------------------AAAAA-A GAGCAG--GAGT----AGCTATACTTATATC-AGACAAAATAGATTTCAAG-AC------ ----AAAAACTA---TAAAAAGA----AAAG-AAGGTCAT------TATAT------AAT GATAAA---GGGGTCAATT------CAGCAA---GAGG--------AT-ATAACAA-TTA TAA-----------------A----TATAAATG---------CACCCAACACTGGAGCAC CCAG--ATA-TATAAAGCAAATATTATTAGAGCT--AA----AGAGAGA---------GA TAGACCCCAAT------ACAATAATAGCTGGAGACTTCAACA----------------CC CCACT------TTCAGC-ATTGGACAGATCAT---------------------CCAGAC- -----AGAA-------------AATCAACAAAGAAACATTGGACTTAATC-TGCACTATA GA------CCAAATGG---ACCTAATAGATATTTACA--GA----ACATTTCATCCAATG GC---TGCAGAATACACAT------TCTTCTCCTCAG-----CA--CAT-GGATCATTCT --C----AAGGATAGACCATATGTTAGGCCACAAAACAAG-------------------- -TCTTAAAAAATTCAAAAAAA--TTGAAAT----------------AATATCAA------ -GTATCTTCTCT---GACCACAATGGAA-TAAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------AG --------------AGG-AATTTTGG---AAACTATACAA----ACACATGGAAA--T-T AAACAATATG-CTCCTGAA---TG-ACCAGTG--GGTCAATGAAGA--AAT--T-AAGAA GAAAATT---------------GAAAAATTTCTT---GAAAC------------------ ------AAATGATAATGG-AAA------------CACAAC--ATACCAAAACCTA-TGG- GA-----TACAGCAAAAGCAGTA-----------------------------CTAAGAGG GAAG--TTTATAGCTATA----AGTAC----CTACATCAAAAAAG---TAGAAAAACTT- --CAAATAAAC-AACCTAA-TGATGCATCTT---AAAGAAC--TAGAAAAGC------AA GA-----GCAAACCAAAC-------------CCAAAAT--TAGTAGAA-GAAAAGAAATA ATA---AAGATCAGA-------------------GCAGAAATA---AA-T-GAAATTGAA ATGAA------AA------------------------------------AAA-AAA---T ACAAAAGATC-A---------ATG----AAACAA-AAAGTTG------GTTTTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATTGACAAACCT---TTAG CCA------GACTAA-----------------AAAAA------------------AAAAG A---GAGA-AGACCC-----------------AAATAAA--------TAAAA-----TC- ---------AGA-GATGAAA--AA----------GGAGA---CATTACAACTGATACC-A CA-GAAATT--CAAAGGAT-CATTAG---------AGGCTACT--ATGAG---------- -----------CAA---CTATATGCCAATAA---ATTGGAAAACCTAG---AAGAAAT-- GGATAAATTCCT----------AGACACA---------TAC-----AACCTACCA----- -AGATTGAACCA---TGAAGAAATCCAAAACCTGAAC----------------------- AGACC------------AA-TAACAAGTAATGAGATTGAAG-C---------CATAAT-- -AAAAAGTCTCCC------AGCAAAGAAAAG---CCCAGGACC--CAATGG--------- ------------CTTCACT-GCTG--AA-------------------TTTTA-------- ----CCAAACATTT---AAAGAA-GAACTAA--TA-CCAATC----------CTACTCAA ACTATT----CC---AAAAAATAGAG------GAGGAG-GG-----------AATACTTC CAAACTCATTCT-----ATGAGGCC-----AGTAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGAC AAA---------------------GAC---ACATCAAAAAA---AGAAAACTAC------ -------------A-GGCCAATAT---CCC----TGATGAACATTGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACCA------------------AA--TT--------------CA--ACA----- --------ACACATT---------AAAAAGATCATTCA--TCATGAC------------C AAG---TGGGA-TT----------TATCCCA------------GG--GATGCAAGGATGG -T----------------------TC-AAC-----ATATGC--AAATCAATCAA--TGTG ---ATACATCATAT------CAACAG----AATGAAGGACAAAAAC---CATATGA---- -TCATTTCAATT---GATGC---TGAAAAAGCATTTGATAA---AATTCAACATCCCTT- ---------------CATGA---------T---A--AA-----AACCCTCAAA---AAAC TGGGTATAGAAGGAACAT-----ACCTCAACATAATAAA--------------------- ------AGCCATATAT-GACAGA--------CCCACAGC-----------TAGTAT--CA TACTGAATGGGGA-----AAA-ACTGAAAGC----CTTT---CCT----CT--AAGATCT GGAACA----AGACAAGG-ATGC--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTGTTATTC---AACATAGT ACT---GGAAGTCCTAGCTAGAGCAAT--------CAG-AC------AAGAG---AAAGA --AATAAAGGGCATCCAAATTGGA---AAGGAA------GAAGTCAAA--T--------- ------TATCCTTG-TT--T---GCAGA------TGATAT------GATCTTATATTTG- -GAAAAAC--CTAAAGA---CTCCACCA---------A---------------AA--AAC TATTAGAACT---------GA--TAAACAAATTCAGTAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------CAT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCATTTC--TA-TATGCCAAC---------------AGTGAACAAT-----CTG A------------------AAAAGAAATC-AAG----AAAGTAATCCCATTTACAATAGC TACA------------------AATAAAATA---------AAA------TACCTAGGAAT TAACTT--------AA--C-CAAAGAAGTG---A---AAGATCTCT---ACAA-TGAAAA CTATAAAACAT------TGATG-AAAGAAATTG-AA------------GAGG-------- ------------ACAC--AAAA--AAA---TGGA---AA--AATAT---------TCCA- --TGTTC------ATG-GATTGGAAGAATC-A---A---TATT--------------G-- TTAAAATG-----------------------------------------TCCAT--ACTA CCC-AA--AGCAATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--A---------------------CCAATG-AC---ATTCTT ------------------------------------------CACAGAAATAG------- ----------------------AAAAAACAAT------CCTAAAA---TTTATATGGAAC C-------ACAAAAGACCCA---GA--ATAGCCAAAGCTATCCTGAGCA---AAAA--GA ACA---AAAC--T-------GGA--GGAATCACA---TTACCTGACTTCAAATT-----A TACTAC-------------------------AG---AGCTATAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--CA------------T---AAAAACAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAT-- -CCAT----------------ACA-------TCTACAG----TGAACT--CATTTTT--- AACAAA--GGTGCCAAGAACATAC--A-------------------TTGGG--GA---AA GG------------ACAGTCTCTT--CAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-ATATCCA---------------TATGC-AGAAGA---ATG ---------AAACTAGACCCC---TATCT-----------CTTGCC--ATA--T---ACA AAAA-TCAAAT-CAAAATGG---AT---TAAAGAC---TTAAATCTA--AGACCTCAAAC TAT------------------------GAAACTACTAAAA---------------GAAAA ---CATT-------------------------GGGGAAACTCTCCAGGACATTG--GAC- -----TGGGCAAAGATT-----TCTTGAGTAA-TACCCCA---CAAGCACAGGCAAC--- --CAAAGCA---AA----AAT---GGACAAA-TGGGAT----------CACATC-AA--- GTTAAAAA-----G------------CTT-CTGCA-------CA--------------GC -AAAGGAAACAAT-------------CAACAAAGTGAAGAG------------------- ------A-------------CAACCC------ACAGAA--T-GGGAG---AAAATATTT- --GCAAACTATCCAT--------CT-------GACAAGGGAT--------TA--ATAAC- ---CAGAATATATAAG-GA--GCTCAA---ACA------AC--TCTAT------------ ---AGG--------------AAAAAAAATTCTAAT--AATCTAA-TTAA---AAAATGGG C--AAA---------AGA--TCTGA---AT---AGACATTT------------------- -----CTCAAAAGAA--------GACATAC---AA-ATGGCAAAC--AGGTATATGAAAA GGT----------GCTCAACATCATTG-ATCATCA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACTACA-------AT---- ----GA---GATATCA---------TCTC----ACCCCAGTTAAAATGGCTTTTAT---C C--AAAAA-------ACAGGCA-----ATAACA--ATG--C------------------- ------TGGT-GAGGATGTG----------GAGAA------------------------- ------------AAGGGAACCCTTGT-ACACTGTTGG--TGGG----------------- ----------AAAGT--A-------------AATTT--AGTAA----AACCCCTATGG-- ------AAAACAGTT--TGGAG--G-TTCCTC--AAAAAACTAAAA--ATAGAACTACC- -ATAT---GA--TCCAGCAATCCCA---------------------CTGCTAGG-TATA- --------------TACCCCAAAAAAA------------AGAAAATCA----G------- --------------TATATTGA--AGAGATATCTGC---------ACTCT----CATGTT TATT--GCAGCACTATTCACAA-TAGCCAAAATTTTGG--GA--AGCA--ACCTAA---G TGTCCATCA---ACAGATG-----AATGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------CATAT----ACACAATGGAGTAC-----T--ATTCA GCCATAA----AA----------------------AAGAATGAGATCCTGTCATTT---- ------------------------------------------------------------ --------GCAACAACATGGATGGAA-C---TGGAGGTCATTATGTTAAGTGA------- ------------------------------------------------AATAAGCCAGGC ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAG---------------------------------ACAAACTT-CG-------- ---CAT---GTTCTCACTTAT----------TTGTGGGCT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAATTAAAACAATTGAA---------------CTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GAGATAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GTAGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----GATGGTT-----------------------------------------------A CCA-------GAGGCTGGGA-------AGGGTAGTGGGGGGGGGGGGGGGGAAGTGGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TGGTTAATGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAAAAATATAGTTA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GAATGAATAAG------------------------------ ---------------ATCTAGTATTTGATAGCACA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACAGGGT-GACTACAG------------------------------------------- ------------------------------------------TCAACAAT---------- --------------AATTTATTGTACATTTTAAAATAACTAAAAGAGTATAATTGGATTG TTTGTAACACAAAGA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAGGATAAATGCTTGAGGTGATGGATACCCCATTTA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CCCTGATGTGATTATTATGCATTGTATGCCTGTATCAAAATATCTCA- --TGTACCCCATAAATATATACACCTACTATGTACCCACAAAAATTAAAA---------- ------ >L1MA1 ------------------------------------------------------------ ------------------------------------------------------------ --------GGGGAGGCGGAGCAAG-----------------ATGGCAGAATAGAAAGCTC CACCGATTG----------------------------TCCCCCCTGCAAG---------- ----------------------------------------GACACCAAGTTAACAACTAT CTACACAGAAAAAAACACCTTCATAAGAACCAAAAATCAGGTG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGCTCATAGTA------------- --CCTGGTTTTAACTTCATATCGCTGAAAGAGGC---------ACTGAAGAAATAGAAAA AACAGTCCTGAATC---------------------------------------------- ---------------------------------------------------------ACC GATGCCACCCCTCCCCCACCCCCGGCAGCGGCAG----------CATGGTGCAGAGAGCA TCTCTGGGTGCTGGGGGAGGGAGAACACAGCAATTGTGAGGCATTGAACTCAGTGCTGTC CTGTTAGAGCAGAAAGGAAAACCAGACCAAACTCAGCTGATGCCCGC------------- -----------------------------------------------------CCACGGA GGGAGCATTTAAACCAGCCCTAGCCAGAGGGGAATCGCCGATCCCAGTGGTCCGAACTTG AGT--------------------------------------------------------- ------------------------------------------------------------ -------------------------------GCCTGCAAACCTCACCACCGAGGGCTACA GCGCTCTGTGTCTCCAAG-------TAAACTTGAAAGGCAGTCTAGGCCATAAGGACTGC AACTCTTAGGCGAGTC-------------------------------------------- -----------------------------------------------CTAGTGCTGAACT AGGCCCAGAGACAGTGGACTGGGGGGGCACGTG------------ACATACTGAGACACC AGCTGGGGCAGCCAAGGGAGTGCTGGCATCACCCCTC----------------------- ---------------------------CCCTAACCCCAGGCTGCACAGCTCATGGCTCCA AAAGAGACCCCTTCCTTCCACTTGAGGAGAGGAGAGGGAAG------------------- ------------------------------------------------------------ ----AGTGGGGAGGAT-------------------------------------------- ------------------------------------------------------------ --------------------------------------------TTGTCTTGCATCTTGG ATACCAGCTCAGCCACAGCAGGATAGGGCGGTCAGAGTCGTGAGGCCCCTGTTCCA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GCCCTAGCTC-------CCAGATGACATTTCTAGACACAC CCTGGGCCAGAAGGGAACCCG--------------------------------------- --------------------CTGCCTTGAAGGAAAGGACCCAGTCCTGGCAGCATTCATC ACCTGCTAACTGAAGAGCCCTTGGGCCCTGAATAACCAGCAGCGATACCCAGGTACTACA TCGAG--GGCCTTGGGTGAGCCTCTGAGACTTGCTGGCTTCAGGTGAGACTCAGCACATT ACCAGCTGTGGTGGCTATGGGGCAAAACTCCTTCTGCTTGAGAAAAGCAGAGGGAAAAGT AAAGGGGACTTTGTCTTGCACCTTAGGTACCAGCACGGCCACAGGGGGGTAGAGCACCAA GTGGGCTCTTGGGGTCCCTGATTCCAGGACTTGACTCTTGGATGGCATTTCTGGACCTGC CCTGGGCCAGAGGGGAGCCCACTGCCCTGAAGGGTGAGTCCCAGGCCAGGCAGCATTCAC CACAAGCTGACTTAAGAGACCTTGGGCCTTAAGGGAACATCGGTGGTAGTCTGGCAGTAC TCCTCGTGGCCTGGGGTGGCGGTGGCTATGGGGTGAGGCTCCTCTGCCTTTGGAAAGGGG AGGGAAGAGTGGGA---------------------------------------------- --------------AGGACTGCATCTTGTGGTTTGAGTGCCAGCTCAGCTGCAATACAAT AGAACACCAGGTAGACTTCTAAGGTTTTTGACTCTAGTCCCTGACTCCCGGATGGCACTT CTGGACCCACCCGGGGCCTGGGGGACCTCGCCGCCCTGAAGGGAAGGACACAGGCCTGGC TGGCTTTGCCACCTGCTGATTGTAGAGCCCCAGGG----CCTTGAGCGAACATAGGCAGT AGCCAGGGAGTGGTTACAGCAGGCC----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TTGGGTGAGACCCAGTG CTGTGCTGGCTTCAGGTCTGACCCAGTGCAGTCATAGTGGTGGTGGCCACAGGGGTGCTT GTGTCACTCCACCCCCAGCTTTAGGTGGCTCAGAACAGAGAGAGAGACTCTGTATGTTTG GGA-----------GAAAGTAAGGGAAGAGAACAAGAGTCTCTGCCTGGTAAT------- ----------------------------------------------CCAGAGAATTCTCC CGGATCTTGTCCAAGACCATCAAGGCGGTACCTCTATGAGTCTGCAAGAAC--------- ---------CACAGTGTTACTGGGCTTGGGGTGCCCCCTAAAGCAGATACAGC------- -TTAGATCACAACACCCAAGTCCTTTCAAATATCTGGAAAGCCTTCCCAAGAAGGA---- ------------------------------------------------------------ -------------------------------TGGCTACAAATAAGCCCAGACAGTGAAGA CTACAATAAATACCTAACTCTTCAATGCCCAGACACCGAAGAACATCTACTAGCATCAAC ACCATCCAGGAAAACA-------------TGAC----CTCACCAA---A-TG-------- -------AAC----TAAATAAGGC-------------------AC-CAG---GGACCAAT CCTGGAG----------------AAA---CAGAGATATGTGACCTTTCAGACAG------ ------AGAA------------TTCAAAATAGCTGT-GTTGAGGAAACTCAAAGAAAT-- --TCAAGATAACACAGAGAAGGAATTCAGAATTCTATCAGATAAATTTAAC-------AA AGAGATT---------------------------------------------GAAATAAT TAAAAAGAA--------------------------------------------------- ----TCAAGCAAAATTCTGGAGCTGAAAAATGCAGAAATTTTATTGTATAAATTTACCGG AGAAACAG-----------------------------------AGATATGGTATAACAAA ----------GAGA----TTGAAATAATTTTAAAAA------ATCAAAGAGAAATTCTG- GAGC----TGAAA---------AATGC---AATTGGCATACTGAAGAATGCATCAGAG-- ---TCCTTTAATAGCAGA----------------ATTG--------------------AT C--AAGC------------------AGAAGAAAG-AAT-TAGTG--AGCTTGAAGAC--- -AGGCTATTTGAAAAT------ACACAGTCAA---------AGAAGACAAAA---GAAAA AAGA---ATAAAAAAC-AA---------TGA---AGCATGCCTAC--AGGATCTAGAAA- ATAGC--------C---TCAAAAG--GGCAAATCTAAGA--G-TTATTGG-----C---- ----------CTTAAAGAGGAGGTAGAGAAAGAG---ATAGGGGTAG---------AAAG TTTATTC---AA-----AGGGATAATAACA--GAGAACTTCCCAAACCT----------- ---------AGAGAAAGATAT--CAAT--ATCCAAGTAC-----AAGAAGGTTATAGA-A CACCAAGCA------------GATTTAA-CCC--------------AAAGAAGACTACCT C-------A---------------------AGGCATTTAATAATCAAACT------CCC- AAAGGTCAAGG---ATAAAG--AAAGGATCC----------------------------- -------------TAAAAGC--AGCAAGAGA---AAAGAAACAAAT-------------- -----------AAC---ATACAATGG-AGCTCCAA--------------TACATCT--GG CAGCAGACTTT-----TCAGTGGAA--ACCTTA-CAGGC------CAG-GAGAGAGTG-- -----------GCA-TGACATA-T-------TTAAAG--TGCT-------------GAAG GAAAA---------------AAACTT--TTA--CCCTAGAA--------TAG---TATAT CTG-----------GTGAAAATATCC-----TTCAA-ACATGA-------AG-------- ------------------------G-AGAAATAAAGACTTTCCCAGACAAACAAAAAGCT GAGGGA-TTTCATCAATACCAGAC---CTGTCCTAC-AAGAA------------------ --------------------ATGCTAAAGGG----------------------------- -----------------------------------AGTAC--------------TTCAAT CAG----------------------------------------------------AAAGA ACAAAACTCA-------------------------------------------------- -------------------------------CTGGTAATAGTA----------------- ------------------------------------AGTACAC----------------- --------AGAAAAACACAGAATATTATAACACTGTAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --CTGTGGTGTGTAAACTACTCTTATCCTAAGTAGAAAGACTAAATGATGAACCAATCAA AAATAATAAC-------------------------------------------------- --------------------------------------------------TACAACAACT TTTCAAGACATAGTACAATAAGATATAAATAGAAACAACAAAAAGTTAAAAAGCAGGGGG ACGAAGTTAAGGCATAGAGTT--------------------------------------- ---------------------------------------------TTTATTAGTTTTCTT TTTGCTTGTTTGTT---TATGCAAATAGTGTTAAGTTGTTATCAGGTTAAAATAATGG-- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GT-------- -------------------------------------------------------TATAA GATAGTATTTGCAAGCCTCATG----------------------------GTAACCTCAA ACCAAAAACA-TACAATGGATACACAAAAAAT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AAAAAGCAAG AAACTAAATCATATCACCAGAGAAAATCACCTTCACTAGAGGAAGACAGGAAGGAAAGAA AGAAGGAAGAGAAGACCA------------------------------------------ ---------------------CAAAACAACCAGA--------------AA---ACAAATA ACAAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------TGGCA-------GGAGTAAGT--------------------- ------------------------------------------------------------ --------------------CCTTACTTA--TCAATAATAAC-ATTGAAT-------G-T AAAT--GGACT--AAACTC---TCCAATC----------------AAAAGAC------AT AGAC--TGGCTG----AATG---------GAT-------GAAA---AAACAAGACCCAT- ---TGA-------TCT-GTTGCCTA-CAAGAAACACACTT-CACCT--ATAAAGACACAC A-TAGACTGAAAATAAAGGGA---T------------GGAAA----A-AGATATTCCATG C--------------CAATGG------AAACC---------------------AAAAA-A GAGCAG--GAGT----CACTATACTTATATC-AGACAAAATAGATTTCAAG-AC------ ----AAAAACTA---TAAGAAGAGAC-AAAG-AAGGTCAC------TATAT------AAT GATAAA---GGGGTCAATT------CAGCAA---GAGG--------AT-ATAACAA-TTT TAA-----------------A----TATATATG---------CACCCAACACTGGAGCAC CCAG--ATA-TATAAAGGAAATATTATTAGAGCT--AA----AGAGAGA---------GA TAGGCCCCAAT------ACAATAATAGCTGGAGACTTCAACA----------------CC CCACT------TTCAGC-ATTGGACAGATCTT---------------------CCAGAC- -----AGAA-------------AATCAACAAAGAAACATCAGACTTAATC-TGCACTATA GA------CCAAATGG---ATCTAATAGATATTTACA--GA----ACATTTCATCCAAGA GC---TGCAGAATACACAT------TCTTTTCCTCAG-----CA--CAT-GGATCATTCT --C----AAGGATAGACCATATGTTAGGTCACAAAACAAG-------------------- -TCTTAAAACATTCAAAAAAA--TTGAAAT----------------AATATCAA------ -GCATCTTCTCT---GACCACAATGGAA-TAAAACTAGAAATTAAT-------------- ----------------------------------------------AACA--------AG --------------AGG-AATTTTGG---AAACTATACAA----ATACATGGAAA--T-T AAACAATATG-CTCCTGAA---TG-ACCAGTG--GGTCAATGAAGA--AAT--T-AAGAA GGAAATT---------------GAAAAATTTCTT---GAAAC------------------ ------AAATGATAATGG-AAA------------CACAAC--ATACCAAAACCTA-TGG- GA-----TACAGCAAAAGCAGTA-----------------------------CTAAGAGG GAAG--TTTATAGCTATA----AGTGC----CTACATCAAAAAAG---AGGAAAAACTT- --CAAATAAAC-AATCTAA-TAATGCATCTT---AAAGAAC--TAGAAAAGC------AA GA-----GCAAACCAAAC-------------CCAAAAT--TAGTAGAA-GAAAAGAAATA ATA---AAGATCAGA-------------------GCAGAAATA---AA-T-GAAATTGAA ATGAA------AA------------------------------------AAA-------T ACAAAAGATA-A---------ATA----AAACAA-AAAGTTG------TTTTTTTGAAAA GTTAAA------------------------------------------------------ --------------------------------CAA-----AATTGACAAACCT---TTAG CCA------GACTAA-----------------AAAAA------------------AAAAG A---GAGA-AGATCC-----------------AAATAAA--------TAAAA-----TC- ---------AGA-AATGAAA--AA----------GGAGA---CATTACAACTGATACT-G CA-GAAATT--CAAAGGAT-CATTAG---------TGGCTACT--ATGAG---------- -----------CAA---CTATATGCCAATAA---ATTGGAAAATCTAG---AAGAAAT-- GGACAAATTCCT----------AGATACA---------TAC-----AACCTACCA----- -AGATTGAACCA---GGAAGAAATCCAAAACCTGAAC----------------------- AGACC------------AA-TAACAAGTAATGAGATCAAAG-C---------CATAAT-- -AAAAAGTCTCCC------AGTAAAGAAAAG---CCCAGGACC--TGATGG--------- ------------CTTCACT-GCTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAAGAA-GAACTAA--TA-CCAATC----------CTACTCAA ACTATT----CC---AAAAAATAGAG------GAGGAG-GG-----------AATACTTC CAAACTCATTCT-----ATGAGGCC-----AGTAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGAC AAA---------------------GAC---ACATCAAAAAA---AGAAAACTAC------ -------------A-GGCCAATAT---CTC----TGATGAATATTGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACCA------------------AA--TT--------------CA--ACA----- --------ATACATT---------AGAAAGATCATTCA--TCATGAC------------C AAG---TGGGA-TT----------TATCCCT------------GG--GATGCAAGGATGG -T----------------------TC-AAC-----ATATGC--AAATCAATCAA--TGTG ---ATACATCATAT------CAACAG----AATGAAGGATAAAAAC---CATATGA---- -TCATTTCAATT---GATGC---TGAAAAAGCATTTGATAA---AATTCAACATCCCTT- ---------------CATGA---------T---A--AA-----AACCCTCAAA---AAAC TGGGGATAGAAGGAACAT-----ACCTCAACATAATAAA--------------------- ------AGCCATATAT-GACAGA--------CCCACAGC-----------TAGTAT--CA TACTGAATGGGGA-----AAA-ACTGAAAGC----CTTT---CCT----CT--AAGATCT GGAACA----CGACAAGG-ATGC--CCACTG----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTGTTATTC---AACATAGT ACT---GGAAGTCCTAGCTAGAGCAAT--------CAG-AC------AAGAG---AAAGA --TATAAAGGGCATCCAAATTGGA---AAGGAA------GAAGTCAAA--T--------- ------TATCCTTG-TT--T---GCAGA------TGATAT------GATCTTATATTTG- -GAAAAAC--CTAAAGA---CTCCACAA---------G---------------AA--AAC TATTAGAACT---------GA--TAAACAAATTCAGTAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------CAT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCATTTC--TA-TATGCCAAC---------------AGTGAACAAT-----GTG A------------------AAAAGAAATTTAA-----AAAGTAATCCCATTTACAATAGC CACA------------------CATAAAATT---------AAA------TACCTAGGAAT TAACTT--------AA--C-CAAAGAAGTG---A---AAGATCTCT---ATAA-TGAAAA CTATAAAACAC------TGATG-AAAGAAATTG-AA------------GAGG-------- ------------ACAC--CAAA--AAA---TGGA---AA--AATAT---------TCCA- --TGTTC------ATG-GATTGGAAGAATC-A---A---TATT--------------G-- TTAAAATG-----------------------------------------TCCAT--ACTA CCC-AA--AGCAATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--A---------------------CCAATG-AC---ATTCTT ------------------------------------------CACAGAAATAG------- ----------------------AAAAAAAAAT------CCTAAAA---TTTATATGGAAC C-------ACAAAAGACCCA---GA--ATAGCCAAAGCTATCCTAAGCA---AAAA--GA ACA---AAAC--T-------GGA--GGAATCACA---TTACCTGACTTCAAATT-----A TACTAC-------------------------AG---AGCTATAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--CA------------T---AAAAACAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAACAAAT-- -CCAC----------------ACA-------CCTACAG----TGAACT--CATTTTT--- GACAAA--GGTGCCAAGAACATAC--A-------------------CTGGG--GA---AA AG------------ACAGTCTCTT--CAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-ATATCCA---------------TATGC-AGAAGA---ATG ---------AAACTAGACCCC---TATCT-----------CTCACC--ATA--T---ACA AAAA-TCAAAT-CAAAATGG---AT---TAAAGAC---TTAAATCTA--AGACCTCAAAC TAT------------------------GAAACTACTACAA---------------GAAAA ---CATT-------------------------GGGGAAAATCTCCAGGACATTG--GTC- -----TGGGCAAAAATT-----TCTTGAGCAA-TACCCCA---CAAGCACAGGCAAC--- --CAAAGCA---AA----AAT---GGACAAA-TGGGAT----------CACATC-AA--- GTTAAAAA-----G------------CTT-CTGCA-------CA--------------GC -AAAGGATACAAT-------------CAACAAAGTGAAGAG------------------- ------A-------------CAACCC------ACAGAA--T-GGGAG---AAAATATTT- --GCAAACTACCCAT--------CT-------GACAAGGGAT--------TA--ATAAC- ---CAGAATATATAAG-GA--GCTCAA---ACA------AC--TCTAT------------ --------------------AGGAAAAAATCTAAT--AATCTGA-TCAA---AAAATGGG C--AAA---------AGA--TTTGA---AT---AGACATTT------------------- -----CTCAAAAGAA--------GACATAC---AA-ATGGCAAAC--AGGCATATGAAAA GGT----------GCTCAACATCATTG-ATCATCA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACTACA-------AT---- ----GA---GATATCA---------TCTC----ACCCCAGTTAAAATGGCTTATAT---C C--AAAAG-------ACAGGCA-----ATAACA-AATG--C------------------- ------TGGC-AAGGATGTG----------GAGAA------------------------- ------------AAGGGAACCCTTGT-ACACTGTTGG--TGGG----------------- ----------AATGT--A-------------AATT---AGTAC----AACCACTATGG-- ------AGAACAGTT--TGGAG--G-TTCCTC--AAAAAACTAAAA--ATTGAGCTACC- -ATAT---GA--TCCAGCAATCCCA---------------------CTGCTGGG-TATA- --------------TA-CCCAAAAGAA------------AGGAAATCA----G------- --------------TATATCAA--AGAGATATCTGC---------ACTCC----TATGTT TGTT--GCAGCACTGTTTACAA-TAGCTAAGATTT--G--GA--AGCA--ACCTAA---G TGTCCATCA---ACAGATG-----AATGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------CATAT----ACACAATGGAGTAC-----T--ATTCA GCCATAA----AA----------------------AAGAATGAGATCCAGTCATTT---- ------------------------------------------------------------ --------GCAACAACATGGATGGAA-C---TGGAGATCATTATGTTAAGTGA------- ------------------------------------------------AATAAGCCAGGC ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAG---------------------------------ACAAACAT-CA-------- ---CAT---GTTCTCACTTAT----------TTGTGGGGATCT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAATCAAAACAATTGAA---------------CTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACATAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GTAGAAG------ ------------------------------------------------------------ ------------------------------------------------------------ -----GATGGTT-----------------------------------------------A CCA-------GAGGCTGGGA-------AGGGTAGTGGGGGGTGGGGGGGAGGTGGGGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TGGTTAATGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------AAAAAAAAATAGAAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GAATGAATAAG------------------------------ ---------------ACCTACTATTTGATAGCACA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACAGGGT-GACTATAG------------------------------------------- ------------------------------------------TCAATAAT---------- -------------AACTTAATTGTACATTTTAAAATAACTTAAAGAGTGTAATTGGATTG TTTG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TAACTCAAGGATAAATGCTTGAGGGGATGGATACCC--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------CATTCTCCATGATGTGCTTATTTCACATTGCATGCCTGTATCAAAACATCTCAT GTACCCATAAATATATACACCTACTATGTACCCACAAAAATTAAA--------------- ------ >L1MA2 ------------------------------------------------------------ --------------------------------------------------------TGAT GGGGGGGGGGGGAGAGAAAAAGAG-----------------GGAAAGAAATCGGGACACA TCATTCTTCCCCCGTGAGAAGGACACCAATTTAACAATACTCACAAAAAAAAAAGCA--- ----------------------------------CCTCCATAAGAACCAAAAATCA---- -GGTGAGCACTCATAGTACCTGGTTTTAACTTCATATTACTGA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------AAGAGGCACTGAAGAGGTAGGAAA------AACAGTCCTGA-------ATCGCT GATGCCACCCCTCCCCCAACCCCCGGCAGCGGTG---------GTGTGGTGTGGAGAGTG TTTCTGGGCGCTGG----------GGGAGGG----------------------------- ---------------------------------AGAGCACAGCAATTGTGAGGCATTGAA CTCAGTGCTGTCCTGTTATAGCAGAAAGGAAAAC-----CA---GACCAAACTCAGCTGA TACCCACCCATAG---------------------------------------AGGGAGCA TTTAAACCAGCCCTAGCCAGAGGGGAATCACTGATCCCAGCGGTCAGAACTTGAGTTCCC ACAAGC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CTCACCACCACG GGCTAAAGTGCTCTGGGGCTCCAAATAAACTTGAAAGGCAGTCTAGGCCACAAGGACTGC AACTCCTAGGTGAGTC-------------------------------------------- -----------------------------------------------CTAGTGTTGAACT TGGCCCAGAGACAGTGGACCTGGGGGGGCATGTG-----------ACCTACCGAGACACC AGCCAGGGCAGCTAAGGGA--------------------------------------GTG CTGGCATCACCTCTC------------CCCCAACCCCCGGCTGCACAGCTCACAGCTCCA AAAGAGACCCCTTCCTTCCACTTGAGGAGAGGAGAGGGAAG------------------- ------------------------------------------------------------ ----AGTGGGGAGGACTTTGTCTTGCATCTTGG--------------------------- ------------------------------------------------------------ -------------------------------------------------ATACCAGCT-- ---------CAGCCACAGCAGGATAGGGCACCGGTCAGAGTCATGAGGCCCCCATTCCAG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GCCCTAGCTC-------CCAGACGACATTTCTAGACACAC CCTAGGCCAGAAGGGAACCCG--------------------------------------- --------------------CTGCCTTGAAGGGAAGGACCCAGTCCTGGCAGGATTCATC ACCTGCTAACTGAAGAGCCCTTGGGCCCTGAATAACCAGCAGTGATACCCAGGTACTACG TCGAG-GGCCTTGGGTGAGACTCTGAGACTTGCTGGCTTCAGGTGAGACTCAGCACATTC CCAGCTGTGGTGGCTATGGAGCAAGACTCCTTCCTCCTTGAGAAAAGCAGAGGGAAAAGT AAAGGGGACTTTGTCTTGCACCTTAGGTACCAGCTCGGCCACAGGGGGGTAGAGCACCAA GTGGGCTCTTGGGGTCCCCGATTCCAAGACTTGGCTCTTGGACGGCATTTCTGGACCTGC CCTGGGCCAGAGGGGAACCCACTCCCCTGAAGGGTGAGTCCCAGGCCAGGCAGCATTCAC CACAAGCTGACTGAAGAGCCCTTGGGCCTTAAGGGAACATCAGCAGTAGTCTGGCAGTAC TCCCCGTGGGCCTGTGGTGGTGGTGGCCATGGGGTGAGGCTCCTCTGCCTTTGGAAAGGG GAGAGAAGAGTGGG--------------------------------AAGGACTGCGTCTT GT------------GGTTTGAGTGCCAGCTCAGCCGCAGTACAATAGAACACCAGGTAGA CTTCTAAG---------------GTTTTTGACTCTAGTCCCTGGCTCCCAGACGGCACCT CTGGACCCGCCTGGGGCCTGGGGGAACTTGCTGCCCTGAAGGGAAGGACACAGGCCTGGC TTGCTTTGCCACCTGCTGATTGTAGAGCCCCAGGG----CCTTGAGTGAACATAGGCGGT AGCCAGGGAGTGGTTACAGCAGGCC----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TTGGGTGAGACCCAGTG CTGTGCTGGCTTCAGGTCTGACCCAGCGCAGTCCTAGTGGTGGTGGCCACAGGGGTGCTT GTGTCACTCCATCCCCCGCTCGATTTGGCTCGGTCAGAAAAGAGAGACTCCCTTTGTTTG GGA-----------GAAAATAAGGGAAGAGAACAAGAATCTCTGCCTGGTAAT------- ----------------------------------------------CCAGAGAATTCTTC CGGATTTTGTCCAAGACCATCAAGGTGGTACCTCTATGAGTCTGCAAGAAC--------- ---------CACAGCGTTACTGGGCTTGGGGTGCCCCCTAAAGCAAATACAGCTTA---- -GATCACAACACCCAAGTCCTTTCGAATATCTGGAAAGCCTTCCCAAGAAGGA------- ------------------------------------------------------------ -------------------------------TGGGTACAAACAAGCCCAGACTGCGAAGA CTACAATAAATACCTAACTCTTCAATGCCCAGACACAGATGAACATCTACAAGCATCAAG ACCATCCAGGAAAACA-------------TGAC--CTCA--CCAA---A-TG-------- -------AAC----TAAATAAGGC-------------------AC-CAG---GGACCAAT CCTGGAG----------------AAA---CAGAGATATGTGACCTTTCAGACAG------ ------AGAA------------TTCAAAAAAGCTGT-TTTGAGAAAACTCAAAGAAAT-- --TCAAGATAACACA--------------------------GAGAAGGAATTC------- AGAATTC----------------------------------------TATCAGATAAATT TAACAAAGA--------------------------------------------------- -GATTAAA-------------AATAATAAATAAA-------------------------- -------------------------------------------ATAAAGGAGATGGAATA ----------GA-----------------TAAGAAGAATCAAGCA--------------- GAGT----TGAAA---------AATGC---AATTGACATACTGAAGAATGCATCAGAG-- ---TCTCTTAATAGCAGA----------------ATTG--------------------AT C--AAGC------------------AGAAGAAAG-AAT-TAGTG--AGCTTGAAGAC--- -AGGCTATTTGAAAAT------ACACAGACAG---------GAGAAACAAAA---GAAAA AAGA---ATAAAAAAC-AA---------TGA---AGCATGCCTAC--AAGATCTAGAAA- ATAGC--------C---TCAAAAG--GGCAAATCTAAGA--G-TTATTGG-----C---- ----------CTTAAAGAGGAGGTAGAGAAAGAG---ATAGGGGTAG---------AAAG TTTATTC---AA-----AGGGATAATAACA--GAGAACTTCCCAAACCT----------- ---------AGAGAAAGATAT--CAAT--ATTCAAGTAC-----AAGAAGGTTATAGA-A CACCAAGCA------------GATTTAA-CCC--------------AAAGAAGACTACCT C-------A---------------------AGGCATTTAATAATCAAACT------CCC- AAAGGTCAAGG---ATAAAG--AAAGGATCC----------------------------- -------------TAAAAGC--AGCAAGAGA---AAAGAAACAAAT-------------- -----------AAC---ATACAATGG-AGCTCCAA--------------TACGTCT--GG CAGCAGACTTT-----TCAGTGGAA--ACCTTA-CAGGC------CAG-GAGAGAGTG-- -----------GCA-TGACATA-T-------TTAAAG--TGCT-------------GAAG GAAAA---------------AAACTT--TTA--CCCTAGAA--------TAG---TATAT CCA-----------GTGAAAATATCC-----TTCAA-ACATGA-------AG-------- ------------------------G-AGAAATAAAGACTTTCCCAGACAAAC-AAAAGCT GAGGGA-TTTCATCAACACCAGAC---CTGTCCTAC-AAGAA------------------ --------------------ATGCTAAAGGG----------------------------- -----------------------------------AGTTC-------------TTCAATC TGA----------------------------------------------------AAGAA CAAAACTCA--------------------------------------------------- -------------------------------CTGGTAATAGTA----------------- ------------------------------------AGTACAC----------------- --------AGAAAAACACAGAATATTATAACACTGTAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --CTGTGGTGTGTAAACTACTCTTATCCTAAGTAGAAAGACTAAATGATGAACCAATCAA AAATAATAAC-------------------------------------------------- ---------------------TACAACAACTTTTCAAGACATAGACAGTACAATA----- --------------------AGATATAAATAGAAACAACAAAAAGTTAAAAAGCAGGGGG ACAAAGTTAAGGTGTAGAGTT--------------------------------------- -----------------------------------------TTTATTAGTTTTCTTTTTG CTTGTTTGTTTGTT---TATGCAATCAGTGTTAAGTTGTTATCAGCTTAA---------- --------AATAATGG-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------GT-------- -------------------------------------------------------TATAA GATAGTATTTGCAAGCCTCATG----------------------------GTAACCTCAA ACCAAAAAAC-ATACAATGGATACACA--------------------------------- ---------------------AAAAATAAAAA---------------------------- ------------------------------------------------------------ --------------------------------------------------GCAAGAAACT AAATCATATCACCAGAGAAAATCACCTTCACTAAAAGGAAGACAGGAAGGAAAGAAAGAA GGAAGAGAAGACCA---------------------------------------------- ---------------------CAAAACAACCAGA--------------AA---ACAAATA ACAAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------TGGCA-------GGAGTAAGT--------------------- ------------------------------------------------------------ --------------------CCTTACTTA--TCAATAATAAC-ATTGAAT-------G-T AAAT--GGACT--AAACTC---TCCAATC----------------AAAAGAC------AT AGAG--TGGCTG----AATG---------GAT-------GAAA---AAACAAGACCCAT- ---TGA-------TCT-GTTGCCTA-CAAGAAACACACTT-CACCT--ATAAAGACACAC A-TAGACTGAAAATAAAGGGA---T------------GGAAA----A-AGATATTCCATG C--------------CAATGG------AAACC---------------------AAAAA-A GAGCAG--GAGT----AGCTATACTTATATC-AGAAAAAATAAATTTTAAG--------- ----AAAAAAAATTTTAAAAAGAAAC-AAAA-AAGGTCAC------TATAT------AAT GATAAA---GGGGTCAATT------CAGCAA---GAGG--------AT-ATAACAA-TTT TAA-----------------A----TATATATG---------CACCCAACACTGGAGCAC CCAGATATA-TATAAAACAAATATTATTAGAGCT--AA----AGAGAGA---------GA TAGACCCCAAT------ACAATAATAGCTGGAGACTTCAACA----------------CC CCACT------TTCAGC-ATTGGACAGATCTT---------------------CCAGAC- -----AGAA-------------AATCAACAAAGAAACATTAGACTTAATC-TGCACTATA GA------CCAAATGG---ATCTAATAGATATTTACA--GA----ACATTTCATCCAATG GC---TGCAGAATACACAT------TCTTTTCCTCAG-----CA--CAT-GGATCATTCT --C----AAGGATAGACCATATGTTAGGTCACAAAACAAG-------------------- -TCTTAAAACATTCAAAAAAA--TTGAAAT----------------AATATCAA------ -GCATCTTCTCT---GACCACAATGGAA-TAAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------AG --------------AGG-AATTTTGG---AAACTATACAA----ATACATGGAAA--T-T AAACAATATG-CTCCTGAA---TG-ACCAGTG--GGTCAATGAAGA--AAT--T-AAGAA GGAAATT---------------GAAAAATTTCTT---GAAAC------------------ ------AAATGATAATGG-AAA------------CACAAC--ATACCAAAACCTA-TGG- GA-----TACAGCAAAAGCAGTA-----------------------------CTAAGAGG GAAA--TTTATAGCTATA----AGTGC----CTACATCAAAAAAG---AAGAAAAACTT- --CAAATAAAC-AACCTAA-TGATGCATCTT---AAAGAAC--TAGAAAAGC------AA GA-----GCAAACCAAAC-------------CCAAAAT--TAGTAGAA-GAAAAGAAATA ATA---AAGATCAGA-------------------GCAGAAATA---AA-T-GAAATTGAA ATGAA------GA------------------------------------AAA-CAA---T ACAAAAGATC-A---------ATG----AAACAA-AAAGTTG------GTTTTTTGAAAA GTTAAA------------------------------------------------------ --------------------------------CAA-----AATTGACAAACCT---TTAG CCA------GACTAA--GAA------------AAAAA----------------------- ----GAGA-AGACCC-----------------AAATAAA--------TAAAA-----TC- ---------AGA-GATGAAA--AA----------GGAGA---CATTACAACTGATACT-G CA-GAAATT--CAAAGGAT-CATTAG---------TGGCTACT--ATGAG---------- -----------CAA---CTATATGCCAATAA---ATTGGAAAATCTAG---AAGAAAT-- GGACAAATTCCT----------AGACACA---------TAC-----AACCTACCA----- -AGATTGAACCA---TGAAGAAATCCAAAACCTGAAC----------------------- AGACC------------AA-TAACAAGTAATGAGATCAAAG-C---------TGTAAT-- -AAAAAGTCTCCC------AGTAAAGAAAAG---CCCAGGACC--TAATGG--------- ------------CTTCACT-GCTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAAGAA-GAACTAA--TA-CCAATC----------CTACTCAA ACTATT----CC---AAAAAATAGAG------GAGGAG-GG-----------AATACTTC CAAACTCATTCT-----ATGAGGCC-----AGTAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGAC AAA---------------------GAC---ACATCAAAAAA---AGAAAACTAC------ -------------A-GGCCAATAT---CTC----TGATGAATATTGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACCA------------------AA--TT--------------CA--ACA----- --------ATACATT---------AAAAAGATCATTCA--TCATGAC------------C AAG---TGGGA-TT----------TATCCCT------------GG--GATGCAAGGATGG -T----------------------TC-AAC-----ATATGC--AAATCAATCAA--TGTG ---ATACATCATAT------CAACAG----AATGAAGGACAAAAAC---CATATGA---- -TCATTTCAATT---GATGC---TGAAAAAGCATTTGATAA---AATTCAACATCCCTT- ---------------CATGA---------T---A--AA-----AACCCTCAAA---AAAC TGGGGATAGAAGGAACAT-----ACCTCAACATAATAAA--------------------- ------AGCCATATAT-GACAGA--------CCCACAGC-----------TAGTAT--CA TACTGAATGGGGA-----AAA-ACTGAAAGC----CTTT---CCT----CT--AAGATCT GGAACA----CAACAAGG-ATGC--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTGTTATTC---AACATAGT ACT---GGAAGTCCTAGCTAGAGCAAT--------CAG-AC------AAGAG---AAAGA --AATAAAGGGCATCCAAATTGGA---AAGGAA------GAAGTCAAA--T--------- ------TATCCTTG-TT--T---GCAGA------TGATAT------GATCTTATATTTG- -GAAAAAC--CTAAAGA---CTCCACAA---------A---------------AA--AAC TATTAGAACT---------GA--TAAACAAATTCAGTAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------CAT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCATTTC--TA-TATGCCAAC---------------AGTGAACAAT-----CTG A------------------AAAAGAAATA-AAA----AAAGTAATCCCATTTACAATAGC CACA------------------AATAAAATT---------AAA------TACCTAGGAAT TAACTT--------AA--C-CAAAGAAGTG---A---AAGATCTCT---ACAA-TGAAAA CTATAAAACAC------TGATG-AAAGAAATTG-AA------------GAGG-------- ------------ACAC--CAAA--AAA---TGGA---AA--AATAT---------TCCA- --TGTTC------ATG-GATTGGAAGAATC-A---A---TATT--------------G-- TTAAAATG-----------------------------------------TCCAT--ACTA CCC-AA--AGCAATCTACA-------------------GA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--A---------------------CCAATG-AC---ATTCTT ------------------------------------------CACAGAAATAG------- ----------------------AAAAAACAAT------CCTAAAA---TTTATATGGAAC C-------ACAAAAGACCCA---GA--ATAGCCAAAGCTATCCTAAGCA---AAAA--GA ACA---AAAC--T-------GGA--GGAATCACA---TTACCTGACTTCAAATT-----A TACTAC-------------------------AG---AGCTATAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--CA------------T---AAAAACAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAACAAAT-- -CCAC----------------ACA-------CCTACAG----TGAACT--CATTTTT--- GACAAA--GGTGCCAAGAACATAC--A-------------------CTGGG--GA---AA AG------------ACAGTCTCTT--CAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-ATATCCA---------------TATGC-AGAAGA---ATG ---------AAACTAGACCCC---TATCT-----------CTCACC--ATA--T---ACA AAAA-TCAAAT-CAAAATGG---AT---TAAAGAC---TTAAATCTA--AGACCTCAAAC TAT------------------------GAAACTACTACAA---------------GAAAA ---CATT------G------------------G-GGAAACTCTCCAGGACATTG--GTC- -----TGGGCAAAAATT-----TCTTGAGTAA-TACCCCA---CAAGCACAGGCAAC--- --CAAAGCA---AA----AAT---GGACAAA-TGGGAT----------CACATC-AA--- GTTAAAAA-----G------------CTT-CTGCA-------CA--------------GC -AAAGGAAACAAT-------------CAACAAAGTGAAGAG------------------- ------A-------------CAACCC------ACAGAA--T-GGGAG---AAAATATTT- --GCAAACTACCCAT--------CT-------GACAAGGGAT--------TA--ATAAC- ---CAGAATATATAAG-GA--GCTCAA---ACA------AC--TCTAT------------ --------------------AGGAAAAAATCTAAT--AATCTAA-TTAA---AAAATGGG C--AAA---------AGA--TTTGA---AT---AGACATTT------------------- -----CTCAAAAGAA--------GACATAC---AA-ATGGCAAAC--AGGCATATGAAAA GGT----------GCTCAACATCATTG-ATCATCA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACTACA-------AT---- ----GA---GATATCA---------TCTC----ACCCCAGTTAAAATGGCTTTTAT---C C--AAAAG-------ACAGGCA-----ATAACA-AATG--C------------------- ------TGGC-GAGGATGTG----------GAGAA------------------------- ------------AAGGGAACCCTTGT-ACACTGTTGG--TGGG----------------- ----------AATGT--A-------------AATT---AGTAC----AACCACTATGG-- ------AGAACAGTT--TGGAG--G-TTCCTC--AAAAAACTAAAA--ATAGAGCTACC- -ATAT---GA--TCCAGCAATCCCA---------------------CTGCTGGG-TATA- --------------TA-CCCAAAAGAA------------AGGAAATCA----G------- --------------TATATAAA--AGAGATATCTGC---------ACTCC----CATGTT TGTT--GCAGCACTGTTCACAA-TAGCCAAGATTT--G--GA--AGCA--ACCTAA---G TGTCCATCA---ACAGATG-----AATGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------CATAT----ACACAATGGAGTAC-----T--ATTCA GCCATAA----AA----------------------AAGAATGAGATCCTGTCATTT---- ------------------------------------------------------------ --------GCAACAACATGGATGGAA-C---TGGAGGTCATTATGTTAAGTGA------- ------------------------------------------------AATAAGCCAGGC ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAG---------------------------------ACAAACAT-CA-------- ---CAT---GTTCTCACTTAT----------TTGTGGGGATCT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAATCAAAACAATTGAA---------------CTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GAGATAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GTAGAAG------ ------------------------------------------------------------ ------------------------------------------------------------ -----GATGGTT-----------------------------------------------A CCA-------GAGGCTGGGA------AGGGTAGTGGGGGGGTGGGGGGGGAGGTGGGG-- -------------------------------------------------AT--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------GGTTAATGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----CAAAAAAAAATAGTTAGAAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------GAATGAATAAG------------------------------ ---------------ACCTAGTATTTGATAGCACA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACAGGGT-GACTATAG------------------------------------------- ------------------------------------------TCAATAAT---------- -------------AATTTAATTGTACATTTTAAAATAACTAAAAGAGTATAATTGGATTG TTTGTAACACA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAGGATAAATGCTTGAGGGGATGGATACCCCATTTT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CCATGATGTGATTATTATGCATTGCATGCCTGTATCAAAACA--TCTC A-TGTACCCCATAAATATATACACCTACTATGTACCCACAAAAATTAAA----------- ------ >L1MC4 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GACTTCTGGGTTTGGAGAACAATGGTGGTGGC CTGATTCCA-----------------------AATCTCCCCCTCATCCTTCC-------- ----------------------------------CAAACAACCATAAAATCAACCA---- ---TGCGCTCCACGCCCTCA---GCATCACTGAAGACAGAGAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------TACCACAACCTTCAAATTATATGT------AAGTAGAAAAG-------AGTTCC CACAGCCCACCTACCACCACTGCAAGCCTGTGGG---------TACAGAGAATGGGAGAG GAGAGGCTGAGCAG----------AGGACAG-------------------------AGAA GAA-------------------------------------GAACCGAAGATACAGACAAA ATCACTCCCAGAAGTGGAACAATAAAAGCCAAAA-----TA---CTAAGCACAGGTTGGA ACTTGATAGTCCACAGCCCTGACAAGGGGGTGAAGAAGTAGCAGCCTCAGAGAAGCAGTG TTGGAGAATCAGATACGGAGAGAAGAGGTGGTCTCCCCTGGAGACATGGCAGTGAAGGGA AAGAAG---------------------------------------GAAATGAGAGGGGAA AATTAAGGAACCAGCAGAAACAAAACAGAAGCAAGATATACCAACCCTCCCCCC------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TCCCACCCAACCC----CACCACCATCCA TAAAGAAACTGCACGGAAGAGGGCACTCTCAAACTAGGAACCCTGTCCACGAAATGAATA GGAATAGATAAAACAG-------------------------------------------- --------------------------------------------------------ACCA TATCCATACTACTGCAAAATGTCAGAAAACGT-------------GAATAAAATCTTTTC TGCTGATGAAAAG----------------------------------------------- -----TCTCCCCCAC------------AAACAACAA---ACATGAAGAAAGAAAACTGTA ACACAATACTCCAAACTGAACTAAATATTCTCAAACAAGCA------------------- ------------------------------------------------------------ ----TTTAGGGA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TATGAAAAAT-- ---------AAAAACCTAAGAACAGAAATGGACAAGAAAAAAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------CAAGCAAAACAAACAAAGGAAG AAATGAAATGAGTTGACTAAAGTTAGAG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AGAAAGAAAAAGACAA AATTATATCAGAAATGAAGACTAAATTACAAGGTGCCC---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------AAGGAAG--------------------------------AACAGATTGA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AATGAAAAC-----------TTAATAAAGAACATTGA ------------------------------------------------------------ --------------------------AGAAAAATCAGAAAAACAACA------------- --A-----------AGAGAATGAAAATGAGATAAAGAAGTAAAATGGGTC---------- ----------------------------------------------AGAAAGAAAATAGT TGAAATGGAAGACAGGAAAGGAGGTCCAACATAAATGATGTCCTTGAAGAA--------- ---------GAAAAATCAAAACAATGAAACA----------------------------- -GAATATTATTTAAAATTATAATCCAAGAAAA---------------------------- ------------------------------------------------------------ -------------------------------TGGGGAAAAA-----ACAGAGCAGAAAAA CCG-------------------------------------GAAACTCTA--------AAA AGCA----GAGCGCCT-------------CTCC--TCCT--CCAA---A-GG-------- -------AAT----GCAGCTCCTC-------------------ACTCAG---CAACGGAA CAAAGCT----GG------ACGGAGA---ATGACTTTGACGAGTTGAGAGAAGA------ ------AGAC------------TTCAGACGATGGGT----ATCAAACTACTCCGAGCT-- --ACAGGAGGAAATT--------------------------CAAACCAAAGGC-----AA AGAAGTT---------------------------------------------GAAAACTT T-GAAAAAA-------------------------------------------------AT TCATTAGA----------CGAATGTATAACTGGA-------------------------- -------------------------------------------ATAACCAATACAGAGAA ----------GTGC---------------TTAAAGG------AGC---------TGACG- GAGC----TGAAA---------AACGCCAAGGCTCGAGAACTACATGAAGAACGCAGA-- ---AGCCTCAAGAGCCGA----------------TGCG--------------------AT C--AACT------------------GGAAGAAAG-GGT-ATCAG--TGATGGAAGAC--- -AAAATGAATGAAA-T-----GAAGCGAGAAG---------GGAAGTTTAGA---GAAAA AAGATGGATAAAAAGA-AA---------CAAAATACAAAGCCTCC--AAGAAATATGGG- ACTAT--------G---TGAAAAG--ACCAAATCTACGT--C-TGATTAG--TGTA---- ----------CCTGAAAGTGACAGGGAGAATGGA---ACCAAGTTGG---------AAAA CACTCTG---CA-----GGATATTATCCAG--GAGAACTTCCCCAATCT----------- ---------AGCAAGGCAGGC--CAAC--ATTCAGATTC-----AGGAAATACAGAGA-A CGCCACAAA------------GATACTC-CTC--------------GAGAAGAGCAACTC C-------A---------------------AGGCACATAATTGTCAGATT------CAG- CAAAGTTGAAA---TGAAGG--AAAAAATGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGTCGGGT-------------- -----------TAC---CCACAAAGG-GAAGCCCA--------------TCAGACT--AA CAGCGGATCTC-----TCAGCAGAA--ACTCTA-CAAGC------CAG-AAGAGAGTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAATTT--TCA--ACCCAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCAT-AAGTGA-------AG-------- ------------------------G-AAAAATAAAATACTTTACAGACAAGC-AAATGCT GAGAGA-TTTTGTCACCTCCAGAC---CTGCCCTAA-AAGAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCTC--------------TTAACA TGG----------------------------------------------------ATAGG AACA---------------ACTGGTA---------------------------------- -------------------------------CCAGCCACTGCA----------------- ------------------------------------AAATCAT----------------- --------GCCAAATTGCAAGTTTCGAAGCCACAGAAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AACAGTTTTGAATGTGCCAAACTCAGG GAACACTGTGCACTTGTGACTCTCCTTAGGAATCTACTAGAGGAGGTTAAGCTTCATCCA ACCAAAAAAAAGATAACTGGGAAAACTGTGCAAAAGGACTGATGGTGAACATTTAAAATA TTTAATTGTAGAGCTAAGATTAAAACAAGGGTGGGGTAATGGACTGAAGAGTAATATAAA TATTACGTGTTCTGACAAAGGAGAACAACATATAACTAAAAATGGAAAGAAAAGGAAAAA AAGGGGAAAGTAGAATAAGATCATTGGTTG------------------------------ ---------------------------------TTATAAATGGAATAGATAGTTGTCAAA GGATATCATTTAAA---ACTGACAAAACAGATAGTAAAAGGTTAAGTAAGAAAAAAGGGG TTTATAGGTGCA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CTATAAAAAG-------------------------TATTA ACGCAAAA------------------------------------------GTAACCACTA GAATAAAAAT-ACAAACCTTCTTA------------------------------------ ---------------------AATGAAAAAGAATTTT----------------------- ------------------------------------------------------------ --------------------------------------------------AAAAAGAAAA AAGAAGAAACACCACA-TAAAGAAAACCGTAAATATAATGCATTCAGTAATTACACCCTA AAATAATATGACAGAATTGAGACCAAACACA----------------------------- ---------------------AAACTAATGGGCA--------------AA---ATACCCA GCTCG------------------------------------------------------- ------------------------------------------------------------ -------------CATCATAATA------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCACACATA--TCAATATTAAC-ATTAAAT-------G-T AAAT--GGACT--AAATGC---TCCAATT----------------AAAATAA------CA AGAT--TGGCAA----ATTG---------GAT-------AAAA---AGTCAAGACCCAA- ---CAA-------TAT-GCTGTCTT-CAGGAGACTCATCT-TACAT--ACAAAGACACAC A-TAGGCTGAAAGTAAAAGGA---T------------GGGAA----A-AGATATTCCATG C--------------AAATAG------AAA-----------------------AAAAAAG AAATGG--AGATGTTGCGCTATACTAATATC-AGATAAAATAGACTTTAAA-AC------ ----AAAAAAAG---TGAAAAGAGAC-AAAG-AGGAACAT------TATAT------AAT GATAAA---AGGATCAATT------CATCAA---GAAG--------AT-ATAACAA-TCA TAA-----------------A----TATATATG---------CACCCAACAATAGAGCAC CCAA--ATA-TATGAAGCAAATATTGATAGATCT--AA----AGAGAGA---------AA TAGACAACAAC------ACAATAATAGTAGGAGACTTCAATA----------------CT CCACT------TTCAGC-AATTGAAAAATCAT---------------------CCAGGC- -----AGAA-------------AGTCAATAAGGAAACAGTAGAATTAAAC-AATACTATG AA------CCAAATAG---ACCTAATAGACATATACA--GA----ACATTCCATCCAATA AC---AGCAGAATACACAT------TCTTTTCAAGCA-----CA--CAT-GGAACATTAT --C----CAAGATAGATCATATACTAGGTCATAAAACAAT-------------------- -TCTCAATAAATTTAAAAAAA--TAGAAAT----------------CATACCAA------ -GTATTTTCTCT---GACCACAATGAAA-TTAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------AA --------------AAG-ATAACTAG---AAAATCCACAA----ATACATGGAAA--T-T AAACAACATG-CTCCTAAA---TA-ACCAATG--GGTAAAAGAAGA--AAT--T-AAGAG GGAAATT---------------AAAAAATATTTT---GAAAT------------------ ------AAATGAAAATGA-AAA------------TACAAT--ATACCAAAATCTA-TGG- AA-----TTCAGGCAAAGCAGTA-----------------------------CTTAGAGG GAAA--TTTATAGCACTA----AATGC----CTACATAAAAAAAA---AAAAAAGATCT- --AAAATTAAC-AACCTAA-CATTACAACTC---AAAGAAC--TAAAAAAAC------AA GA-----ACAAACTAAAT-------------CCAAAAC--TAGCAGAA-GAAAAGAAATA ATA---AAGATCAGA-------------------GCAGAAATA---AA-T-GAAATAGAA ACAAA------AA------------------------------------AAA-CCA---T TAAAAAAATT-A---------ATG----AAACCA-AAAGCTG------GTTTTTTAAAAA GATCAA------------------------------------------------------ --------------------------------TAA-----AATTGATAAACCT---CTAG CAA------GACTAA--CTA------------AGAAA------------------AAAAG A---CAGA-AGACCC-----------------AAATAAT--------CAAAA-----TC- ---------AGA-AATGAAA--AA----------GGAGA---TATCACAATTGATCCC-A CA-GAAATA--CAAAGGAT-CATAAA---------AGACTATT--ATAAA---------- -----------CAA---CTATATGCCAACAA---ACTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------GAAAAAA---------TAC-----AACCTACCA----- -AGATTAAATCA---TGAAGAAATAGAAAACCTGAAC----------------------- AGACC------------AA-TAACAAGCAATGAGATTGAAT-C---------AATAAT-- -TAAAAATTTACA------AACAAAAAAAAG---TCCAGGACT--AGATGG--------- ------------CTTCACA-GCTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAAGAA-GAACTAA--TA-CCAATT----------CTTCTCAA ACTATT----CC---AAAAAATAGAA------AAAGAG-GG-----------AATACTTC TAAACTCATTCT-----ATGAGGCC-----AGCAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGGC AAG---------------------GAC---ACAACCAAAAA---AGAAAACTTC------ -------------A-GACCAATAT---CCC----TGATGAACATAGAT------------ ------------GCGAAAATCT-TCA--------------------A----CAAAATACT AGC-AAACTG------------------AA--TC--------------CA--GCA----- --------ACACATT---------AAAAAGATAATACA--CCATGAT------------C AAG---TGGGA-TT----------CATCCCA------------GG--GATGCAAAGATGG -T----------------------TT-AAT-----ATATAC--AAATCAATTAA--TATA ---ATCCATCATAT------AAACAA----AAAAAAGAAGAAAAAC---CATATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCTTTTGACAA---AATCCAACAACTCTT- ---------------TATGA---------T---A--AA-----AACTCTCAGT---AAAC TAGGTATAGAAGGAACAT-----TCCTCAAAATAATAAA--------------------- ------AGCCATCTAT-GACAAA--------CCCACAGC-----------TAACAT--CA TACTGAATGAGGA-----AAA-ACTGAAAGC----ATTT---CTT----CT--AAGAACT GGAACA----AGACAAAG-ATGC--CCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ATT---GGAAGTTCTAGCCAGAGCAAT--------TAG-GC------AGGAG---AAAGA --AATAAAGGGTATCCAAATTGGA---AAGGAA------GAAATAAAA--T--------- ------TATCCTTG-TT--T---GCAGA------TGACAT------GATCGTATATCTA- -AAAAACC--CTAATGA---CTCTACAA---------A---------------AA--AAC TCCTAGAACT---------GA--TAAAAAAATTCAGCAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------TAT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCTTTTC--TA-TACACCAAC---------------AATAAACAAT-----TTG A------------------AAATGAAATC-AAG----GAAGAAATCTCATTTACAATAGC TTCA------------------AAGAAAATA---------AAA------TACCTAGGAAT CAAACT--------AA--C-AAAAAAAGTG---A---AAGATCTCT---ACAA-TGAAAA CTATAAAACAC------TACTAGAAAAAAATTAAAA------------GAAG-------- ------------AC----AAAA--AAA---TGGA---GA--GATAT---------TCCG- --TGCTC------ATG-GATTGAAAAAATC-A---A---TATT--------------G-- TTAAAATG-----------------------------------------TCCAT--ACTA CAC-AA--AGTAATCTACA-------------------GA---TTCAATGCC---ATC-- ------C-CTATCAAAAT--T---------------------CCAATG-AC---TTTCTT ------------------------------------------CACAGAAATAG------- ----------------------AAAAAACAAT------TCTAAAA---TTCACATGGAAC C-------ACAAAAGACCCA---GA--ATAGCCAATGCAATTCTGAGCAAAAAGAT--GA ACA---AAGC--T-------AGA--AGCATCATA---CTACCTGACTTCAAATT-----A TACTAC-------------------------AA---AGCTATAGT-AATCAA---AAC-A GTA--------------TGGTACTGG--CA------------T---AAAAACAGACA--- ---CATAGAT--CA---ATGG-AACAGAATAGAGAGCCC------AG---AAATAAAC-- -CCAC----------------ACA-------TTTATAG----TCAACT--GATCTTT--- AAAAAA--GGGGCGAAAAATAAAC--A-------------------TTGGG--GA---AA GA------------ATATCTTATT--AAATAAATGG---------------TGCTG---- ------G-GAAAGC--TAA-CTAGCCA---------------TAAGA-AGAAAA---ATG ---------AAACTGGATCCC---TATCT-----------CACACC--TTA--T---ACA AAAA-TAAATT-CAAGATGG---AT---TAAAGAC---TTAAATCAT--AGACCTAAAAC TAT------------------------AAAAATCCTAGAA---------------GAAAA ---CATA------G------------------G-GAAAATGCTTCAGGACATTG--GTT- -----TGGGCAAGAACT-----TTTTGGGTTA-AAAACCTAAAAAAACAATGGCAAC--- --AAAAGCA---AA----AAT---TGACAAA-TTGGAT----------TTCATC-AA--- ACTAAAAA-----G------------CTT-CTCCA-------CA--------------GC -AAAAGAAACAAC-------------AATGAGAGTGAAGAG------------------- ------G-------------CAACCT------ACAGAA--T-GGGAG---AAAATATTT- --GCAAACTACTCAT--------CT-------AATAAAGGGC--------TA--ATATC- ---CAGAATCTACAAT-GA--ACTCAA---ACA------AA--TCAAC------------ ---ACG--------------AAAAAAATA---AAC--AACCCAA-TCAA---AAAGTGGG C--AAA---------GGA--CTTGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATTC---AG-ATGGTCAAA--AAACACATGAAAA AAT----------GCTCAACATCACTG-GTCATCA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAAACACA-------AT---- ----GAA--AAAACCA----------CTC----ACAACACTTAGAATGGCGATCAT---T A--AAAAG-------TCAGGAA-----ACAACA-GGTG--C------------------- ------TGGA-GAGGATGTG----------GAGAA------------------------- ------------ATAGGAACACTTTT-ACACTGTTGG--TGGG----------------- ----------ACTGT--A-------------AACT---AGTTC----AACCATTGTGG-- ------AAGTCAGTG--TGGCG--A-TTCCTC--AGGGATCTAGAA--CTAGAAATACC- -ATTT---GA--CCCAGCCATCCCAGTTTATTTTAAAGTTAAATATTTACTGGG-TATA- --------------TA-CCCAAAGGACGGGTATTTACCTAAGAAATCA----T------- --------------GCTGCTAT--AAAGACACATGC---------ACACG----TATGTT TATT--GCGGCACTATTCACAA-TAGCAAAGACTT--G--GA--ACCA--ACCCAA---A TGTCCAACA---ATGATAG-----ACTGGATTAAG--AAAA----TG------------- -----TGGCA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AATGATGAGTTCATGTCCTTT---- ------------------------------------------------------------ --------GTAGGGACATGGATGAAA-T---TGGAAATCACCATTCTCAGTAA------- ------------------------------------------------ACTATCGCAAGA ACAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAACAC-CG-------- ---CAT---ATTCTCACTCAT----------AGGTGGGAACAAATTTCCAATTCAAAAAG ATA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAAAAAGAACAACAATAAA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------TAAAAAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAAGCACAAGAAGGAAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----AATAAAGATAAA------------------------------------------A GCA-------GAAATTAATG------------------------AGGTAGAGAACAGA-- -------------------------------------------------AA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AATAATAGATCA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AATTAATAAATCAAAA------------------------- ---------------TCCTGATTCTTTAAAGAAACAAAAAAAATACT------------- ------------------------------------------------------------ ------------------------------------------------------------ -AATTTAAAGAATAAAA------------------------------------------- --------------------------------------------AAAAAA---------- --------------AAAAACATAAATATATAAAAATAAAAAATGATAT------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAGTTAAAACTTTTAAAAAAAAATATAGATCAATGT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------AAATA--GATA TGAAAATCAAGAGAAAATAATTA------------------------------------- ------ >L1ME4C GCAGCCAAGGGACTGAGATGACTAGGGCACTCGTAACAGAACTTCAGAAGGATGGTACTG AGGGGAAGACATAGAAGCTGGGCTGAAGGAGGAGGAAGCTGGGAACCCTTCATGGGGCTG CCTGGCACCAGAACTCATTCCTTACTCCTGACTACGGGGGAATGGCCGAATAGGAACAGC TCCGGTCTA---------------------------CAGCTCCCAGCATGAG-------- ----------------------------------CTTCTAGAGACGCAGAAGACGG---- -----------GTGATTTCTGCATTTCCATCTGAGGTACCGGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------TTCATCTCACAAGG------GAGTGCCAGAC-------AGTGGG CGCAGGACAGTGGGTGCAGCACACCGTGCACGAG---------C-CGAAGCAGGGTGAGG CATTGCCTCACTTG----------GGAAGCG----------------------------- ------------------------------------------------CAAGGGGTACCA GGGAGTTCCCTTTCCTAGTCAAAGAAAGGGGTGA-----CA---GACGGCACCTGGAAAA TCGGGTCACTCCCAAGTGGTCT------------------------------TGCCCCTA ATACTGGCTGGTCTGACCTGAGAACCCCGTGGGCTGCTGATGTCTGCTTTTCCAACGGGC ---------------------------------------------TTAAAAAACGGCCTT GGTTACACCAGGAGATTATATCCCGCACATG----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCTCGGAGGGTCC---------------- --------ATGCCTGACCAGCAGACTACGCCCACGGAGTCTCACTGACCATCCACTAGCC CACTGGCTCCTTGCTG-------------------------------------------- -------------------GCACAGCAGCTTCCTCCAGTCTGAGATCAAACTGCAAGGTG GCTTTTCCAGTAAGCGAGGCTGGGGGAGGGGC-------------GGCCGCCATTGCCCA GGCTTGCTTAGGTAA--------------------------------------------- ---------------------------------------ACAAAGCAGCCGGGAAGCTCC AA-------------------CTGGGTGGAGCCCACCACAG------------------- ------------------------------------------------------------ ----CTCAAGGAGGCC-------------------------------------------- ------------------------------------------------------------ ----------------------------------------TGCCTGCCTCTGTAGGCTCC GCTGCCAGACCACCTCTGGGGGCAGGGCACAGACAAACAAAAAGACAGCAGTAAC----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CTCTGCAGAC-------TTAAATGTCCCTGTCTGACAGCT TTGAAGAGAGCAAAACTAGGCACAGAGA---------------------------ACAGC GGACCCTTCCTCATCGTGGTTCTCCCAGCACGCAG------------------------- --------------------------CTGGAGATCTGAGAATGGGCAGACTGCCTCCTCA AGTGG-GTCCCTGACCCCTGACCCCTGAGCAGCGTAACT--------------------- ------------------------------------------------------------ --------------------------------------------GGGAGGGACCCCCCAG TAG-------GGGCAGACTGACACCTCACACGGCCGGGTACT------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CCTCTGAGACTGTGGTGAAAA CTTCCAGAGGAACG--------------------------------ATCAGACAGCAGCA TTCTAGCACCCTGCTGCGGTTCATGAAAATCCGCTGTTCTGCAGCCACCGCTGCTG---- ------------------------------------------------------TTACCC AGGCAACCAGGGTCTGGAGAGGGTGGATCCTCCTGCCATCGCACTATGAAATGCACTACT CTGATGGACCTCTAGCAAACTCCAGAGTGTAGTTA----CTACTGGTC--CCAAAACAGA CCTGCAGCTGAGGGTCCTGTGTTCTTAACTTAGAGGAGTTA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAAGGAAAA-----------CTAACAAACAGAAAGGA CATCCACAGAGTTAGAGAATGGAGTCCAGGAGTTGGGGGCTGAGCATTGGCCCCCTAA-- ------------------------------------------------------------ --A-----------ATCTTCAAGATACAAAGCTCCAAAAACCCAT--------------- ----------------------------------------------CTGTACATCACC-- ---------------------------------------ATCATCAAAGAC--------- ---------CAAAAGTCATGAAATAGGATAAG---------------------------- -ATAAAAACCACAAAGATGGCAACTTCAAATAATGAAGAAACATCAGCTCACCAAGATGG ------------------------------------------------------------ -------------------------------GGGAAAAAAA-----ACAGAGCAGAAAAA CTG-------------------------------------AAAACTCTA--------AAA AGCA----GAGTGCCT-------------CTCC--TCCT--CCAA---A-GG-------- -------AAC----GCAACTCCTC-------------------AC-CAG---CAACGGAA CAAAGCT----------GGACGGAGA---ATGACTTTGACGAGTTGAGAGAAGA------ ------AGGC------------TTCAGACGAT----------CAAACTACTCCGAGCT-- --AAAGGAGGAAATT--------------------------CAAACCAAAGGC-----AA AGAAGTT---------------------------------------------AAAAACCT T-GAAAAAA--------------------------------------------------- -AATTAGA----------CAAATGGATAACTAGA-------------------------- -------------------------------------------ATAACCAATACAGAGAA ----------GTCC---------------TTAAAGG------ACC---------TGATG- GAGC----TGAAA---------ACCAA---GGCACAAGAACTACGTGAAGAATGCACA-- ---AGCCTCAGGAGCCGA----------------TGCG--------------------AT C--AACT------------------GGAAGAAAG-GGT-ATCAG--TGATGGAAGAT--- -CAAATGAATGAAA-T-----GAAGCGAGAAG---------AGAAGTTTAGA---GAAAA AAGA---ATAAAAAGA-AA---------CAA---ACAAAGCCTCC--AAGAAATATGGG- ACTAT--------G---TGAAAAG--ACCAAATCTACGT--C-TGATTGG--TGTA---- ----------CCTGAAAGTGACGGGGAGAATGGA---AACAAGTTGG---------AAAA CACTCTG---CA-----GGATATTACCCAA--GAGAACTTCCCCAATCT----------- ---------AGCAAGGCAGGC--CAAC--ATTCAAATTC-----AGGAAATACAGAGA-A CGCCACAAA------------GATACTC-CTC--------------GAGAAGAGCAACTC C-------A---------------------AGACACATAATTGTCAGATT------CAC- CAAAGTTGAAA---TGAAGG--AAAAAATGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGTCGGGT-------------- -----------TAC---CCACAAAGG-GAAGCCCA--------------TCAGACT--AA CAGCGGATCTC-----TCGGCAGAA--ACTCTA-CAAGC------CAG-AAGAGAGTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAATTT--TCA--ACCCAGAA--------TTT---CATAT CCA-----------ACCAAACTAAGC-----TTCAT-AAGTGA-------AG-------- ------------------------G-AGAAATAAAATCCTTTACAGACAAGC-AAATGCT GAGAGA-TTTTGTCACCACCAGGC---CTGCCCTAA-AAGAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCAC--------------TAAACA TGG----------------------------------------------------AAAGG AACA---------------ACCGGTA---------------------------------- -------------------------------CCAGCCACTGCA----------------- ------------------------------------AAAACAT----------------- --------GCCAAATTGGTAAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCATCGAGGC-------------------------TAGGA A-------------------------------------------------GAAATTGCAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CAACTAACGAGCA--------------AA---ATAACCA GCTAA------------------------------------------------------- ------------------------------------------------------------ -------------CATCATAATGAATGGAA------------------------------ ------------------TGGTA------------------------------------- ------------------------------------------------------------ --------------------CCTCACATC--TCAATACTAAC-ATTGAAT-------T-T AAAT--GGCCT--AAATGC---TCCACTT----------------AAAAGAT------AC AGAA--CTGCAG----AATG---------GAT-------AAGA---ATTCACCAAACGA- ---CCA-------TCT-GCTGCCTTGTAAGAGACTCACCTAAATAC--ATAAGGACTCAC ATTAAACTTAAGGTAAAGGTG---T------------GGAAA----A-AGACA--CTATG C--------------AAATGG------ACACC---------------------AAAAG-C AAGCAG--GAGT----AGCTATTCTTCTATC-AGACAAAACAAACTTTACA-GCGGT--- ----AAGAGCAGTT-TAACAAAAGAC-AAAG-AGGGACAT------TATAT------AAT GGTAAA---AGGCCTTGTT------CAACAG---GAAA--------AT-ATCACAA-TCC TAA-----------------A----CATATATG---------CCCCTAACACTGGAGCTC CCAA--ATT-TATAAAACAATTACTAATAGACCC--AAGAA-ATGGATA---------GA TAGACAGCAAC------ACAATAATAGTGGGGAACTTCAATA----------------CT CCACT------GACGGC-ACTAGACAGGTTAT---------------------CAGGAC- -----AGAA-------------AGTCAACAAAGAAACAATGGATTTAAAC-TATACCTTG GA------ACAAATTG---ACTTAACAGATATATACA--GA----ACATTCCATCCAACA AC---TGCAGAATATACAT------TCTATTAAATAG-----CA--CAT-GGAACTTTCT --C----CAAGATAGACCATATGATAGGCCACAAAACGAG-------------------- -ACTCAATAAATTTAAGG-----TCAAAAG----------------TATCTTAA------ -GTACTGTCTCA---GACCACAGTGGAA-TAAAACTGGAAATCAACTCCAAGGAGAATTT GACACAGTGGGCATGGGCATGTGAAGAAAAGAAGAAAGAAAAAAAAAACA--------AA --------------AGG-AACCTTCA---AAACCATGTAA----ATACATGGAAA--T-T AAATAACCTG-CTCCTAAA---TG-ATCACTG--GGTCAAAAATGA--AAT--C-AAGAT GGATATT---------------AAAAAATTATTT---GACCT------------------ ------GAACAACAATGG-TGA------------CACAAC--CTATCAAATCCTC-TGG- GA-----TACAGCAAAGACGGTG-----------------------------CTAAAAGG AAAG--TTTATAGCCCCA----AACGC----CTACAGCAAAAAGA---CTGAAAGAGAA- --CAAACAGAC-AATCTAAGTGTCACACCTC---AAGGAAC--TAGAGAAAC------AA GA-----ACAAACGAAAC-------------CCTAACCAACAGCAGAA-GAAAGGAAATA ACC---AAGATCAGA-------------------GCAGAGCTA---AA-T-GAAATTGAA ACAAA------CA------------------------------------AAC-AAA---T AAATAAAATC-ATTACAAAAGATA----AAACAA-AAAGATG------GTTCTTTGAAAA GATAAA------------------------------------------------------ --------------------------------TAA-----AATTGATAGACCA---CTAG CAA------GATTAA--CCA------------AGAAA------------------ATAAG A---GGAA-AAATCC-----------------AAATAAG--------CTCAA-----TA- ---------AGA-AATGAAA--TG----------AGAGA---TATTACAACTGACACCTA CA-GAAATA--CAAAAGAT-CATTCA---------AAGCTACTAAATGAA---------- -----------CAC---CTTTATTTGCATAA---ACTAGAAAACCTAG---AAATGAT-- GGATACATTACT----------GGAAAGA---------TAC-----TACCCTCCT----- -AGCTTAAATCA---GGAAGAATTAGATACCCCGAAC----------------------- AGTTC------------AA-AAACCAGCAGCGAGATTGAAA-T---------GGTAAT-- -TAAAAATCTATCATCAATAACAAAGAAAAT---CCAAGGCCC--GAATGA--------- ------------TTTTCCG-CATG--AA-------------------TTCTA-------- -----CAAACATTTT--AAAGAA-AAATTAG--TA-CCAATC----------CTATTGAC ACTATT----TC---AAAAAATAGAGTTAGTTAAAGAG-GG-----------AATACTCC CTAAATCATCCT-----ATGAGGCC-----AAGAT---TACCCTA-ATAC---------- ----------------------------------------C--AAAAC-------CAGGC AAG---------------------GACAT-AAAGCCAAAAA---ATAAAACTAG------ -------------ATGATCAATAT---CCC----TGATGAACATACAT------------ ------------GCAAAAATCC-TTA--------------------A----CAAAATACT AGC-AAACCA------------------AA--TT--------------CA--ACA----- --------ATATATT---------GAAAATATAATCCA--CCATGAT------------C AAG---TTGGT-TT----------CATGCCA------------GG--GATGCAAGGATGA -T----------------------TT-AAC-----ATTCTC--AAATCAATAAA--TATG TAAATACACCACAT------AAACAA----AATTAAGGACAAAAAT---TATATGA---- -TCATCTCAATA---GATGCAAAAAAAAAAGCATTCAATAA---AATCCAGCATCCCTT- ---------------TATGA---------T---A--AA-----AATTCTCAGCAAAAAAC TCAACATACAAGGGACAT-----ACCTAAACGTAATAAA--------------------- ------AGCCATCTAT-GACAAA--------CCCACAGC-----------CAACAT--CA TACTGAATGGGAA-----AAA-GTTGAAAAC----ATTT---CCT----CT--GAGAACT GGAACA----AGACAAAG-ATGC--TCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTCTTC---AATGTAGT ACT---GGAAGCCTTAACCAGAGCAAT--------CAG-AC------AAGAG---AAAGA --AATAAAGGGCATCCAAATTGGA---AAAGAG------GAGGTCAAA--C--------- ------TGTCACTG-TT--C---TCTGA------TGATAT------GATCGTCTACCTA- -GAAAACC--CTAAAGA---CTCCTCCA---------G---------------AA--AGC TCCTAGAACT---------GA--TACATGAATTCAGCAAAG--TTT-----CCAGATAC- --AA-------------------------------AATTAA-------------TGT--- ACACAAAT----CAGT-------------------------------------------- -----AGCTCTTC--TA-TATGCCAAC---------------AGCCACAAAG-----CTG A------------------GAAACAAATA-AAG----AACTCAACCCCTTTTACAATAGC TGCA--------------------AAAAATA---------AAAATAAAATACTTAAAAAT ATACCT--------AA--C-CAAGGAGGTG---AATTAAGACCTCT---ACAA-GGAAAA CTACAAAATACTTTGATTGATG-AAATAAATCATAA------------GATG-------- ------------ACAC--AAAC--AAA---TGGATGGAA--CACAT---------CCCA- --TGCTC------ATG-AATGGGTAGAATC-A---A---TATT--------------GAA TGAAAATG-----------------------------------------TCTAC--ATTG CCA-AA--AGCAACCTACA-------------------AA---TTCAATGCA---ATT-- ------C-TCATCAAAAT--A---------------------CCACCA-TC---ATTCTT ------------------------------------------CACAGAATTAG------- --------------------AAAAAAAACAAT------TGTAAAAAATCTCATGTGGAAC C-------AAAAAAGAGTCC---GC--ATAGCCAAAGCAAGACTAAGCA---AAAA--GA ACA---AATC--T-------GGA--GGCATCACA---TTACATGATTTCAAAAT-----A TACTAT-------------------------AA---AGCTACAGT-CACCAA---AAC-A ACA--------------TGGTACTTG--TA------------T---AAAAATAGGTA--- ---CATAGAC--CA---ATGGAAAAAGAATAGAGAAACC------AGAATAAATAAAC-- -TCAA----------------ATA-------CTTACAG----CCGTTCGAGATCTTT--- GACAAA--GCAAACAAAAACATAA--A-------------------GTGGG--GA---AA GG------------ACACCCTTTT--CAACAAATGGGAG------------TGCCG---- ------G-GATAAT--TGG-CTAGCCA---------------AATGT-AGGAGA---ATG ---------AAACTGGATCTT---CATCT-----------TTCACC--TTA--TATAACA AAAA-TCAACT-CAAGATGG---AT---TAAGGAC---TTAAATCTA--AAATCTGAAAC TAT------------------------AAAAATTCTAGAA---------------GATAA ---CATT------G------------------G-AAAAACCCTTCTAGACATTG--ACT- -----TAGGCAAAGATT-----TCTTGACCAA-GAACCCA---AAAGCAAATGCAAC--- --AAAAACA---AA----GAT---AAATAGC-TGGGAC----------TTAAAT-AA--- GCTAAAGA-----G------------CTT-TTGCA-------TG--------------GC -TAAAGGAACAGT-------------CAGCAGAGGAAACAG------------------- ------A-------------CAATCCTGCTTGACAGAA--T-GGGAG---AAAATCTTC- --ACAATCGGACCAC-----------------GA-AAAAAAC--------TA--ATATC- ---CGGAATCTATAAGAGA--ACTCAA---ACA------AA--TCAGC------------ ---AAG--------------AAAAAAAACAAACAGATAATCCCA-TCAA---AAAGTGGG C--TAA---------GGA--CATGA---AT---ATACAATT------------------- -----CTCAAAAGAA--------GATATAC---AA-ATGGCCAAC--AAATATATGAAAA AAT----------GCTCAACATCACTA-ATGATCA------------------------- -----GGGA-AATGGAAA-----------------TC-AAAACCACA-------AT---- ----GC---AATATCA---------CCTT----ACTCCTGCAAGAATGGCCATAAAATCA A--AAAAT-------CAAAAAA-----ACAGTA-GATG--T------------------- ------TGGC-GTGGATGCA----------GTGAA------------------------- ------------CAGGCAACACTTCT-GCACTGCTGG--TGGG----------------- ----------AATGT--A-------------AACT---AGTAT-----ACAACTGTAGA- ------AAAAAAATG--TGGAG--A-TTCCTT--AAAGAACTAAAA--GTAGAACTTAT- -ATTT---GA--TCCAGCAATCCCG---------------------CTACTGGG-TATC- --------------TA-CCCAGAGGAA------------AATAGGTCA----T------- --------------TTTACGAA--AAAGATACTTGC---------ACACG----TGTGTT TATA--GCAGCACAATTCGCAA-TTGCAAAAACGT--G--GA--ACCA--ACCCAA---A TGCACATCA---ATAAACA-----AGTGGATAAAG--AAAC----TG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------ >L1ME3F ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------A---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TGGGGAAAAA-----ACAGAACAGAAAAA AAA-------------------------------------GAAACGCCA--------GAA ACCA----AAGGGCCT-------------CTCC--TCCT--CCAA---A-GG-------- -------AAC----GCAGTTCCTC-------------------AC-CAA---CAACAGAA CAAACAT----GG------ATGGGGA---ATGACTGTGACGAGCTGAGAGAAGA------ ------AGGC------------TTCAGAAGAT----------CAAATTACTCTGAGCT-- --ACGGGAGGACATT--------------------------CAAACCAAAGGC-----AA AGAAGTT---------------------------------------------GAAAACTT T-GGAAAAA--------------------------------------------------- -ACTTAGA----------AGAATGTATAACTAGA-------------------------- -------------------------------------------ATAACCAACAAAGAGAA ----------GTGC---------------TCAAAAC------AAC---------TAATG- GAGC----TGAAA---------ACCAA---GGCTGGAGAACTACGTGAAGAATGCAGA-- ---AGCCTCAGGAGCCAA----------------CGAG--------------------AA T--AAAT------------------GCAAGAAAA-AAT-ATCAA--AAATGGAAGAT--- -GAAATGAATGAAA-T-----GAAAAAACAAG---------GGAAGGGGAGA---GAAAA AAGA---ATAAAAAGA-AA---------TGA---GCAAAGCCTCC--AAGAAATATGGG- ACTAC--------C---TAAAAAG--ACCAAATCTACGT--C-TGATTGG--TGTA---- ----------CCTGAAAGTGATGGGGAGAATGGA---ACAAAAGAGA---------AAAA CAACATC---CA-----GGATATTATCCAG--GAGAACTTCCCCAATCT----------- ---------AGCAAGGCAGGC--CAAC--GTTCAGATTC-----AGGAAATACAGAGA-A CACCACAAA------------GATGCTC-CTC--------------GAGAAGAGCAACTC C-------AAGACACATAATTGTCAGATTCAGACACATAATTGTCAGATT------CAC- CAAAGTTGAAA---TGAAGG--AAAAAATGC----------------------------- -------------TAAGA--------AAACA----------------------------- -----------CAC---AAACAAAGT--------------------------------AA CAGCGGATCTC-----TCGGCAGAA--ACCCTA-CAAGC------CAA-AAGACAAGA-- -----------GGG-ACCAATA-T-------TAAAAA--TGCT-------------CAAA AAAAA---------------AAACTA--TCA--AACCAGAA--------TTC---CACAC CCA-----------ACCAAACTAACC-----TTCAA-AAGTGA-------AA-------- ------------------------G-AGAAATAAAAAACTTCACAGACAAAC-AAAAACT GAAAGA-ATGTGTCACAACCAGAC---CTGCACTAA-AAGAA------------------ --------------------ATCCTGAAAGA----------------------------- -----------------------------------AGCGC--------------TAAACA TGG----------------------------------------------------AAAGG AACA---------------ACCGGTA---------------------------------- -------------------------------CCAGCCGCTGCA----------------- ------------------------------------AAATCAT----------------- --------GCCAAAATGAAGAAGGCTGAATAGAAACAGCTACAGTTGGACACAGATGTAG ATATGGCAGAGATATTAAGATTATCAAACCATGAATTTAAAATGACTATAATTAATATAG TAAGAGTTCCAACAGATAAAGTAGACAACATATAAGGACAGATGGGAAATGTAAGCAGAG AGAGAGTTCCCCTAATAAACAATACAAAATGAGATGCTGGAGAGAATCTGGTAAACTCAT TAGTAGACTGGACATAGCTCACAGATGAAAAAATCTCTGAACTTGAAGATATGTCAGTAG AAAATCACAAATGAAAAGCAAAAAAAACACTGAAAAAAGATAAAACAGAATATCCAAGAA CTGTGAGACAACTAAAGCAGGTGTAAACAAGCTTAAAATGACAATATAAAAAAACAAAAA AGGAATAATAATCTCTGTAGGAGAAAATAATGACTAGAAATTTCCCCCAAATTAATTTCT GACACCAAACCACTGAGCAATCAAGATTGAAGAAAACTACCCAAATTAAGTGAAAAAACA ACTACACCTAAAATATATTCAAAAACCAAAATTGAATAAAAAAAAAAAGATGGGGAAATA ACTATACAGAAAAAAAGATAAGAATTAAATCAAGCTTCTCATCAACCATGTAAGAAAGCT GGTAGAGGAAAATATTAAAAGTGTTCATTAAAAAAAACATCAAACTAGACTTCTAAACCA TATGGAATTATTTT---TAAAATTTTAAAAAAAATTTAGAACTTTGTCAAACAAACAAAA ACTGAAGAAATATGTTAAAAATAGAGATGCCTTATAAGACAAGTTGATTAACTGTAAAAA AGGAGGAAAATAATATAGATCAGAAACTTAGATATAAATAAAGAAAAAGAAAGCAACAAA GAAGAATTGATTAAGGTAAAATAAAAAATTTAATTTTCTTATTCTTAGTTGATATAATAG AAAATAATTGTTCAAAATAATAACAACAACCATATTTATATTATATAGATAAGATTATAA ATATACACCTAGAGAAGA--------------------------------GCAACTCCAA GACACATTAT-ATATATACATATATATATAATGGACAAATGAAATAAATGAAATTAAGGA AAGGAGGAAAAGGAGATCAAAAAAGATAGTAATGTTGTATTATTATAGAGTAATTGCACT ACCCATAAAACAATATAATGTTATTTGAAAGTAAACTTAGATTCATTATAAGTATAAATT AAAAACTCTAAAGAAAACCCTACAATAAAAGAACATATAATTGATAAGCTAAAAATGAAA AGAAAATATAATTACT-AAAATGCTCAAAAACAACCAAAAAAAGAAAGAAAAAGAAGGTA AGAAAAAAACTGCAA--------------------------------------------- ---------------------CAACTCACAAGAA--------------AA---ATAACCA GAAAA------------------------------------------------------- ------------------------------------------------------------ -------------CAGTAAAAAGGCAGAAA------------------------------ ------------------TGGCA-------GACATCAAT--------------------- ------------------------------------------------------------ --------------------CCAACTATA--TCAATAATCAC-TTCAGAT-------G-T CAAT--GGTCT--AGATAA---ACCAATT----------------AAAAGAT------AC AGAT--TGTCAG----AGTG---------GAT-------CAAA---AAACAAGACCTAG- ---TGA-------TAT-GGTGTCTA-CAGGAAATCCACTT-TAAAT--ATAAAGAAAAAT A-CAGGTTAAAAGTAATGGGA---T------------GGAGA----A-ATATATACCATG C--------------TAGCAT------GAATC---------------------AAAAG-A AAGCTA--GAGT----AACTATATTAATTTC-AGGTATATCAGGTAGCAGA-GC------ ----AGGAAAAT---TTATCAGTGAT-AAAG-AGGGGTAT------TACAT------AAT GATGAA---GAGATCAGTT------ATCCAA---GAAG--------AC-ATAAATA-CCC TTA-----------------A----TGAGCAGG---------CACTTAATACCCGAGTGT CAAA--ATG-TATGAGGCAAAAATTGATAGAACTTGAAGGACAAAGAAATGAATCCATTA TAGACTTCCAC------ACAATTGTAGTTGGCAACTTCAACA----------------AC CCTCT------ATCAGAGAATGGACAGATAGA---------------------GCAGGT- ---ACAGAA-------------ATTCAGCAAGGGCACAGTTAAACTCAAA-TCAGCTCTG CA------CCAATGGG---ATATAATTGACATCTGTATCAA----ATACTTCATTCAACA GC---AAAAGAATACACATTATACATTTTTTCAAGTT-----CA--CATACACACATTCA --C----CAAAACAGATCACATTCTTGGCCATAGAATATG-------------------- -CCCTAACAAATTCAAAAGAA--TGAAAAT----------------CATACAAT------ -GTCTGCTCTCA---GACTACGATGGAA-TTAAACTTGAACTAAAT-------------- ----------------------------------------------AACA--------GA --------------AAG-ATATGTGG---AAAACCCCCAA----ATACTTGGAGA--T-T AAATAACACA-CTTCCAAA---TG-ACTACACA-AATCAAAGAAGA--TAT----CTCAA AAAAATT---------------TTACAATATTTT---GAACT------------------ ------AAATAAAAATAA-AGA------------CACAAC--ATACCAAAATTTA-TGG- GA-----TATAGCAAAAGCAATG-----------------------------CTAAGAAG AAAA--TTTATAACATTG----AATGC----ATTTATTATAAAAG---AAGAAAGATCT- --AAGATGAGT-AGTGTGA-GGTTTCTCCTT---AGTAAAC---TGAAAAAT------AA GA-----GTAATACTAAT-------------CCAAACC--AAACAGAAGAAAATGAAATA ATA---AAAATTAAT-------------------GTCGAAATT---AA-T-AAAATTAAA AATAG------GA------------------------------------AAT-CTA---T AGAGAAGATC-A---------ATG----AAATTC-AAATTTG------GTTCTTTTAAAA GATGGA------------------------------------------------------ --------------------------------TGA-----AATTGATAAACCT---CTAG CCT------ATCTAA--TTA------------AGAAA------------------AAAA- ----GAGAAGAGCAC-----------------AAATTAC--------TAATA-----TC- ---------AGATATTGAAA--GA----------GGGGA---CATCACTACAGATTCC-A TG-GACATT--AAAAGAAT-AATAAG---------AAAATAGT--ATAAA---------- -----------CACCAACTCTATGCAAGTAA---ACTAGACAATTTAG---ATAAAAT-- GGACAAATTTCT----------TTAAAGA---------TAC-----AGTTTCTCA----- -AAACTAACCCA---AGAAAAGGTAGAAAATCTAAAT----------------------- ATGCC------------TA-TATGTATTGAAGAAATTGAAT-C---------AATTAT-- -TAATAGCCTTTC------AAAACATAAAGT---ACCAGGCCT--AGATGGGTTGA---- -----------AATTCATT-GCTGATAA-------------------TTCTA-------- ----CCAAATATTT---AAGTAATAAAATTA--TA-CCAAGT----------CTTTTCAA ACTCTT----CG---ATATAGTAGAA------AAAGAG-AA-----------AATACTCC CTAACTCATTAT-----ATGAGGCA-----AAGAA---AAACCTG-ATAC---------- ----------------------------------TTATACC--AAAAC-------CAGAC AAA---------------------GACTATACAGCAAAGAA---AGAAAATTAT------ -------------A-GACCAATAT---CTC----TCATGAACATGGAT------------ ------------TCAAAAATCT-TCA--------------------A----TAAAATATT AGC-AAACCG------------------A---TT--------------GAATACA----- --------AAGTTT----------AAAAAAACTATACA--CGATGAC------------C AAG---CGGGA-TT----------TATCCCCACCTCGAGTGGGGG--TATGCAAGGCTGG AT----------------------TC-AAA-----ATTTGCGAAAATCAATAAA--TGTA ---ATCCATCACAT------TAACAG----ATTAATGAAGAAAAAT---AACATTA---- -TCATATAAATA---GATGC---AGAAAAAGCATTTGACAA---AATTCATCACTTTTT- ---------------TATGA---------T---A--AA-----AACTCTCAGC---AAAC TAGGGATAGAGGGCACGT-----TTTTCAACTTGATAAG--------------------- ------GAGTATCTAT-AAGAAA--------CCTACAGC-----------TAACAT--CA TACTTAATGGTGA-----AAA-ACTAGAATCTATTATTTTTTCTTTTTACT--AAAATAA AGAACAAACTAGAAATGG-ATGC--CCTATC----------------------------- ------------------------------------------------------------ ----------------------------------TCTCCACTACTTTTC---AACATGGT GCT---GGAAGTCCTAGCCAGTGCAAT--------AAG-AC------AGGAA---AAAGA --AATAAAAGGTATACAAATTGAA---AAATAG------AAACACAAA--T--------- ------TGTCCTTT-TT--C---ACAGA------TGATAT------AATTGTCTATCCA- -ACACACA--CACACGAAAACTCCATTATAATTGTACAAAATATAATTAAACCAA--AAC TCCCAGAACT---------TA--TAGATAATTTCAGCAAAG--TTA-----CAGGATAT- --AA-------------------------------GATAAA-------------TAT--- TCAAAAGC----CAAT-------------------------------------------- -----AGCTTTCC--TC-TTCACCATCTTAAAATCTCAGATAAACAAACAAT-----TAG A------------------AATTCAAATT-ATA----AAACACATTCCTTTTAAAATTAG TGCA------------------AAAAAAATA---------AAA------TACCTACGAAT AAACCT--------AA--C-AAGGGATGTG---A---AGGACCTCT---TCAA-AGATAA GTATAAAACCT------TTATG-AGGGAAATAA-AA------------GATG-------- ------------ATCA--AAAC--AAA---TGGA---AG--AACAT---------TCCAT TTTGCTC------ATG-GGTAGGAAGAATC-A---A---TATC--------------G-- TGAAATTG-----------------------------------------GCAAT--ACTG CCC-AA--GGTAATTTACA-------------------GA---TTCAATGCC---ATC-- ------C-CCATCAAGCT--A---------------------CCAATG-CC---TTTCTT ------------------------------------------CACAGAATTGG------- ----------------------AAAAAACTAC------TTTAAAG---TTCATATGGAGT G-------AAAAGAAAACCC---GC--ATCGCCAAGAAAGTACTAAGCC---AAAA--GA ATA---AACC--TGGAGGCGAAAGAAGAGTCACG---CTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAAACTAAC-A GCA--------------TGGTACTGG--TA------------C---CAAAACAGAGA--- ---TATAGAT--CA---ATGG-AACAGAACAGAGCCCTC------AG---AAATAACT-- -CCGA----------------ATA-------TATACAA----CTTTCT--TGTTTAT--- GACAAC--CCAGAATAAAACAAGCAAATTATTTGGACATGTATTATATGGG--GA---AA GG------------ATTCACTATT--TAATAAATGGAAAGGGAGGCTATTCTGCTA---- ------A-GAAAAC--CAG-CTAACTA---------------TACAT-TGTAAACAGATC ---------AACCTGGATCCC---TTCCT-----------TACACC--TTA--T---ACA AAAA-TCAATT-CTATATGG---AT---TAAAGACAGATTAAACGTT--AGACCTAAAAC CAA---------------------CATAAAAACCCTAGAA---------------GAAAA ---CCTA------G-------AAGGAAAACATGGCATTACCATTCAGGTCATAG--GCA- -----TGGGCATGGACT-----TCATGCCTAA-AACACCA---AAAGCAATGGCAAC--- --AAAAGAC---AA----AAT---TGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAC-------------CATCAGAGTGAACAG------------------- ------G-------------CAACCT------ACAAAA--T-GGGAG---AAAATTTTC- --GCAACCTACTCAT--------CT-------GACAAAGGGC----TACAGAATATATC- ---CAGAATCTACAAT-GA--ACTCAA---ACT------AA--TTTAC------------ ---AAGTCAGTAAA------AA--AAACA---AAC--AACCCCA-TCAA---AAAGTGGG C--GAA---------GGA--CATGAACTAC---AGACACTT------------------- -----CTCAAAAGAA--------GACATTT---AT-GCAGCCAAA--AAACACATGAAAA AAT----------GCTCATCATCACTG-GCCATCA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACACCAGTTAGAATGGCGATCAT---T A--AAAAG-------TCAGGAA-----ACAACA-GGTG--C------------------- ------TGGA-GAGGATGTG----------GAGAA------------------------- ------------ACAGGAACACTTTT-ACACTGTTGG--TGGG----------------- ----------ACTGT--A-------------AACT---AGTTC----AACCATTGTGG-- ------AAGTCAGTG--TGGCG--A-TTCCTC--AGGGATCTAGAA--CTGGAAATAGC- -ATTT---GA--CCCAGCCATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAC------------TATAAATCA----T------- --------------GCTGCTAT--AAAGACACATGC---------AGA------------ ------AAGACAAAAATTAAAA--AGTTAAAAAAT-----AA-----------CAA---G T-----------ATTGGAG-----AAGATATAAAA--AAAA------------------- ------------------------------------------------------------ ------------------------AAGAT----ATACCAAAAAAAAT------------- ---ATAA----AA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---CAT---G-------CTAC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TA------- ------AAAATAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TGTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >L1ME4B ------------------------------------------------------------ ------------------------------------------------------------ ------------------TCCAAG-----------------ATGGCTGAATAGGAACAGC TCTGGTCTG---------------------------TAGCTCCCAGCGAG---------- ---------------------------------------ATCGAAGCAGAAGGCAG---- -----------GTGATTTCTGCATTTCCAACTGAGGCACCTGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------TTCATCTCACTGGG------ACTGGTTGGAC------------- --------AGTGGGTGCAGCCCACGGAGGGTGAG---------C-CGAAGTGGGGCAGGG TGTCACCTCACCCA---------------------------------------------- ------------------------------------------CAAAGTGCAAGGGGTCAA GGGATTTCCCTTTCCTAGCCAAGGGAAGCCGTGA-----CA---GACTGTAGCTGGAGAA ACAGTACACTCCTGACAAAATACTGCACTTTTCC------------------CAACAATC TTGACAACTGAAAAAAAAGGAGATACACTCCCTTGCCTG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCTCAGTGGGTCA---------------- -------------------------CACGCCCATGGAGCCTTGCTCACTGCTAGCGCAGC AGTCTGAGATCAACCT-------------------------------------------- ------------------------------------------------------------ --GCAATGCTGCTGCTTGATGCGGGGAGGGGC-------------GTCTGCCATTGATGA AGCTTGAGTAGCTCACAGCGTAA------------------------------------- ---------------------------------------ACAAAGCAGCAGAGAAGCTTA AA-------------------CAGGGCAGAGCCCACCTCAG------------------- ------------------------------------------------------------ ----ATCAGCAAAGC--------------------------------------------- ------------------------------------------------------------ ----------------------------------------CTACAGCCTCTCTAAATTA- ---------CCACCTCTGGGGACAGCACAAAGCAGAACAAAAAGAGAGCATTAAACCACC AAAGCAAACAGC------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TTCCACAGAC-------TTAAACATACCTGTCTGACAGCT CTAAAGAAAGAAGTGGTTCTATCAACAG-------------------------------- ------------------------------------------------------------ --------CTGAGAGACCCATAAATGTTCAAGATCAAAGAACCAAGAGAACACAACCTCA AGCAG--------GACCCTGAACCCCATGAAGCCTGACA--------------------- ------------------------------------------------------------ --------------------------------------------GGGAGACACATCAAAA AAA-------GAGACAACCAACACTTCAAACAGGCAGGTGCCCTCTGGGACGAAGCTTCC ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGAGGAAGG--------------------------------ATCAGGAAGCAATA TT------------TATTGTTCTGCAGCCTCCGCTGG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----TGATACCCAGGCAAACAGGGTCTGGGGTGGA----CCTCCAGCAAACTCCAACAGG CCTGCAGCTGAGGGGCCTGACGGTTA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAAGGAAAA-----------CTAACAAACAAAAAG-- ------------------------------------------------------------ ------------------------------------------------------------ --------------GAAAAACAACAACATCAACAAAAACCCCTTCGAGCCAAAGA----- ----------------------------------------------ATCTAAATAACA-- ---------------------------------------GACTTCAACATC--------- ------------------------------------------------------------ -AGAACTTCCCTCTGTCTCAGCCCACCCAAA----------------------------- ------------------------------------------------------------ -------------------------------TGAGAAAGAA-----CCAGCACAAGAACA CTA-------------------------------------ACAACTCAA--------AAA GCCA----GAGTGTCT-------------CCTT--TCCT--CCAA---A-TG-------- -------ACT----GCACCAGTTC-------------------CC-TAA---CAAGGGTT CTTAACC----------------AGG---GTGGGATGGCTGCAATGGCAGAAAT------ ------AGAA------------TTCAGAACACGAAT-AGGAAGGAACATCATCAAGAT-- --TCAGAAGAACATT--------------------------AAAACCAAATCT-----AA GGAAGCT---------------------------------------------AGGAATCA C-AATAAAA--------------------------------------------------- -CAATAAA----------TGAGCGGACAGACAAG-------------------------- -------------------------------------------ATAACTATTATAGAATA ----------GAAC---------------ATAACCA------ACC---------TGAAA- GAGC----TGAAT---------AACAC---AATACAAGAATTTCACAATGCAATCACT-- ---AGTATTAACAGCAGA----------------ATAA--------------------AC C--AAGC------------------TGAGGGAAG-AGT-CTCAG--CACTTGAAGAC--- -TGGTTCTCTGAAA-T-----AAGACAGTCAG---------ACAAAAATCAATTTTTAAA AAGA---ATAAAAAGA-AA---------TGA---ACAAAACCTAC--AAGAAGTATGGG- ATTAT--------G---TAAAGAG--ACCAAATCTACCA--A-TCACTGG--CATC---- ----------CCTGAAAGGGAGGGGGAGAAAGCA---AACAACTTAG---------AAAA TATATTT---CA-----GGATATCATCCAT--GAAAATTTCCTCAACTT----------- ---------TGCTAGAGAGGC--CAAC--AGTCAAATTT-----AAGAAATACAGAGA-A CCCCTGAAA------------GATTCTA-CAC--------------AAGAAGATCACCCC C-------A---------------------AGACACATAATTGCCAGATT------TTC- CAAGGTCGAAA---TG------AAAAAATTT----------------------------- -------------TAAAGGC--AGCTAGAGA---AAAAGGGCAAGT-------------- -----------TAC---ATACAAAAG-GATCCTCA--------------TCAGACT--AA CGGCAGACCTC-----TCAGCAGAA--ACCCTA-CAAGCTGTTAATAG-AAGAGATTG-- -----------GGA-ACCTATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------AAAATT--TCA--ACCAAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCCT-AAGTGA-------AG-------- ------------------------A-AGAAATAAAATCATTTTCAGATAAGC-AAACGTT GAGGGA-CTTCATTACCACCAGAC---CTGCCTTAC-AAGCA------------------ --------------------ATCTTGAAAAG----------------------------- -----------------------------------AGTAT--------------TAAATA TAT----------------------------------------------------AAAGG AAAG---------------ACCACTA---------------------------------- -------------------------------TAAGCTAATACA----------------- ------------------------------------AAAACAC----------------- --------AGCATAAA-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GC-------- --------------------CCACAGAAAC-------------------------TATAA A-------------------------------------------------GAAACTACAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CAACAAGCAAACA--------------AA---ACAAACA ACTAA------------------------------------------------------- ------------------------------------------------------------ -------------TATCATG---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCAAACCAC--ACAATGACAAC-CTTGAAT-------G-T AAAT--GGTCT--AAATTC---CCCAATT----------------AAAAGAC------AC AGAC--TGTCAA----AATGATTTAAAAAAAAAAGAAAAAAAA---AAACAAGACCCAA- ---CTC-------TCT-GCTGTCTT-CAAGAGACCCATCT-CATGT--GTAAAAACACAC A-TAGGCTCAAAGTAAAGGGA---C------------GGAAA----A-AGATATACCATG TGA------------AAATGA-----AAAAAC---------------------AAAAA-A AAGCAG--GGGT----TGCTATCCTAATATC-AGATAAAACAGACTTTAAA-CC------ ----AATAAAAA---TCAAAAGAGAC-AAAG-AAAGCTTT------TTTGT--------- TATAAA---GAGATCAATT------CAACAA---GAAG--------AT-ATAACAA-TAC TAA-----------------A----TATATATG---------CACCCAATACTGGAGCAC TCAG--ATT-CATAAAGCAAATATTTATAGACCT--AA----AGAGAGA---------AA TAGACTCCCAT------ACAATAATAATAGGGGACTTCAACA----------------CC CCACTTCAGGCATCAGT-ATTAAACAGATCAA---------------------CAAGAC- -----AGAA-------------AAATAACAAAGAAATACAGGACTTAAACATTAGCTCTA GA------CTAATTGG---ACCTAATAGACATTTACA--GA----AAACTCCACCCAACA TC---TACAGAATACACAT------TCTTCTCATCAC-----CA--CAT-GGAACATATT CAC----TAAAATCGACCACATGTTTGGCCATAAAACAAG-------------------- -TCTCAACAAATTCAAAAAAA--TTGAAAT----------------CACAACAA------ -ACATTCTCTTT---GACCACAGTGGAA-TAAAACTAGAAATCAAT-------------- ----------------------------------------------AACA--------AG --------------AAA-ATTTTTCA---AAACTACACAA----AAACATGGAAAAATCT GAACAACCTG-CTCCTGAA---TG-ACTACTG--GGTAAATAATGA--AAT--A-AAGAC AGAAATT---------------AAAAAATACATT---AAAAT------------------ ------TAATGAAAATAG-AGA------------CACAAC--GAACCAGAATCTA-TGG- AA-----TACAGTTAAAGCAGTA-----------------------------CTAAGAGG GAAG--TTTATAGCACTA----AATGC----CCACATAAGAAAAA---TAGAAAGATCT- --AAAATAAACAAACCTAA-CCTAACACCTC---AATGGACAGTAAAAAAGAAGAAAAAT AA-----AAAAACAAAAC-------------CCAAAGT--AAGCAAGG-AGAAAGAAATA ACT---AAGATCAGA-------------------GCAGAACTG---AA-T-GAAACAGAG ACTTA------AA------------------------------------AAA-CAG---T ACAAAAAATC-A---------ATG----AAACCA-AGAGTTG------GTTTTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATGGATAGACCA---CTAG CAA------GACTAA-----------------AAAAA------------------AAAAG A---GAGA-AGACTC-----------------AAATAAA--------TGCAA-----TC- ---------AGA-AATGAAA--AA----------GGAGA---TATTATAACCGATACC-A CA-GAAATA--CAAAGGAT-CATTAG---------AGACTATT--ATGAA---------- -----------CAA---CTATATGCAAACAA---ATTAGAAAATCTAA---GAAAATT-- GGAAAATTTCTT----------GAAAAAA---------TAA-----ACCTTCCCA----- -GATATGAACCA---GGAAGAAATAGAAAATCTGAAC----------------------- AGACC------------AA-TAACAAGTACTGAGATTAAAT-C---------AGAAAT-- -AAGGTAAATACC------AACTAAAAAAAT---ACAAAGACC--AAATGATCAGATGAC ATGTTACTGTGAATTCACA-GTTG--AA-------------------TTTTA-------- ----CCAAAAATTT---AAAGAA-GAACTGA--TA-CCAATT----------CTCCTGAA ACTATT----CC---AAAAAATAGAA------AAAGAA-GG-----------AATCCTCC CTAACTCATTCT-----ATGAGGCC-----AGCAT---TATCCTG-ATAC---------- ----------------------------------------A--AAAAT-------CTGGC AGA---------------------GAC---ACAATAAAAAA---AGAGAACTTT------ -------------A-GGCCAATAT---CCC----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----TAAAATACT AGC-AAACCA------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGACTATCCA--CCAAAAC------------C AAGTAATGAGA-TT----------CATCCCA------------GG--AATGCAAGGATGG -T----------------------TC-AAC-----ATACGC--AAATCAATAAA--TGTG ---ATACATCACATCA----AAACAG----AACCAATGACAAAAAC---CACATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTTGATAA---AATTCAACATCCTTT- ---------------CATGA---------TAAAA--AA-----AACTCTCAAC---AAAT TAGGTATAGAAGGAATAT-----ACCTCAACATAATAAA--------------------- ------GGCCATTTAT-GACAAA--------CCCACAGC-----------TAATAT--CA TACTGAATGGGCA-----AAA-CCTGAAAGC----CTTT---CCT----CT--AAGAACT AGCACA----AGATAAGGAATGC--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTTTATTC---AACATAGT ACT---GGAAGTTCTAGCCAGAGCAAT--------TAG-GC------AAGAG---AAAGA --AATAAAGGGTATCCAAATTGGA---AAAGAG------GAAGTCAAA--T--------- ------TGTCTCTG-TT--T---GCAGA------TGACAT------GATTTTATATTTA- -GAAAAAC--CTAAAGT---CTCCACCA---------A---------------AA--AAC TCTTTAAGCT---------GA--TAAGCAAATTCAGTAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------CAT--- ACAAAAAT----CAGT-------------------------------------------- -----GGCATTTC--TA-TACACCAAT---------------AATGAACAAA-----CTG A------------------AAGCCAAATC-ATG----AATGAACTCCCATTCAGAATTAC TACA------------------AAGAGAATAAAAGAAACAAAAAAACCCTACCTAGGAAT AAATCT--------AA--C-AAAAGAGGTG---A---AAGATCTCT---ACAA-TGAAAA CTACAAACCAC------TGCTC-AACGAAATAA-AA------------GAGG-------- ------------ACAC--AAAC--AAAAATTGGA---AG--ACAAT---------TCCA- --AGTTC------GTG-GATAGGAATAATT-A---ATGGTATC--------------G-- CGAAAATG-----------------------------------------ATTAT--ACTG CCC-AA--GGCAATCTACA-------------------GA---TTTAGTGCT---ATTCA ACACAACTCCATCAAACT--A---------------------CCATTG-AC---TTTCTT ------------------------------------------CACAGAAATAG------- ---------------------AAAAAAAATACCTAATGTTTAAAT---CTAAAATGGAAC C-------AAAAAAGAGCCT---GA--ATAGCCAAAACAATCCTAAGCA---AAAA--GA ACA---AAAC--C-------TGAAGGGCATCACG---TTACCTGACTTCAAACC-----A TACTACCTGACAAAGTGTGAAATTACCTTACAA---AGTCATATC-AACCAA---AAT-A GCATAACTAAAACAGCTTGGTACTGG--TA------------C---AAAAACAGACA--- ---TATAGAC--TA---ACGG-AACAGAATAGATACCCC------AG---AAATAACT-- -CCAC----------------ATA-------TCTGCAG----TCATCT--GATCTTT--- GACAAA--CATGACAAGAACAAAA--A-------------------TTGGG--GA---AA GG------------ACTCTCTATT--TAATAAATGG---------------TGCTA---- ------G-GAAAAT--TGG-CTAGCCA---------------TATGC-AGAAGA---ATG ---------AAACTAGATCCC---TATCT-----------CTCACT--GTA--T---ACA AAAATTCCAT--CAAAAAGGGAAAT---TAAAGAC---TTAAATGTA--AGACCTAAAAC TAT------------------------AAAACCAGTAGAA---------------GAAAA ---CCTT-------------------------CACAAAACCCTTCAGGACATTG--GCC- -----TGGGCAAAGATT-----TTATGGCTAA-GACCTCAAATAAAGCAAAGGCAAC--- --AAAAGCA---AA----AAT---AGACAAA-TTGGAT----------TATATC-AA--- ACTAAAAA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAT-------------CATCAGAGTGAAGAG------------------- ------A-------------CAATCT------ACAGAA--T-GGGAG---AAAATATTT- --GCAAACTATCCAT--------CT-------GACAAGGAAC--------TA--ATATCT AGATAGAATCTGTAAA-GA--ACTTAA---ACA------AC--TTAAC------------ ---AAC--------------AAAAAAACA---CAT--AACCCAA-CAAA---AAAATTGG C--AAA---------GGA--TCTCA---AT---ATGCATTT------------------- -----CTCAAAAGAT--------AGCATAC---AA-ATGGCC------------------ ------------------------------------------------------------ -----------------------------------TC----------------------- ------------------------------------------------------------ ----------------------------------------C------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >L1PA15 ------------------------------------------------------------ ------------------------------------------------------------ -----------------AGCCAAG-----------------ATGGCTGACTAGACGCAGC CAGGAGGAA---------------------------CATCTCCCACGG------------ ---------------------------------------AGAGACTGGGACATCAG---- ----------GAAGACTGGCACACTCTGAGCAGATCTTCGGAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------GGAAGGCATTGAG------AGTGGATGGAG------------G GAGGACACAGATGCTGGGCTGAAGGGGGAGGAAG---------CTGGGAACCCTGCACGG GGCTACTGAGCACC---------------------------------------------- ---------------------------------------------------GGGACTCGT TCCTGGCCCCCAGCAACTCCTGGGGAAGGGGTGA-----GT---TGAGCAGGCGAGGAGT GGCCCACTCTCAC---------------------------------------CATGGACC TCCGGAATCCTGGCAGCAGGAGACCCCACAACCCCCCCGACACTTGAGCTGGC------- ---------------------------------------------AGGGAGAGCTGCTTA GAGAGGTGGTAGGGGCAGGACTCCAGCCTGTGCGGA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCCCAGAGGGTTTGGTGTGGGAATGTCTG CAGTGGAGCACGGCCAGGGATGCCCATCCCTCAAGGCTCGCCATGCTCCTCTAGGAGACT TTAGCCTTAGGGTGAC-------------------------------------------- --------------------------------TGTCAGACCTGGACAGAGCAGGGCGGTC TTGCCCATGAGATGGGGCCAGTCTGATCTGAGTGCCCCCCTGTCTGCTGGCCTCTCCCGG GGCCCCAGCCTGGCCGCACCTGCTTGCAGTGCAGCCTTGGATGCCCAACCAGGGTGCCTC CTAGGGGCCCTCATCATAGCTCCTTCGCTGGCAGACCATGCCTGACCATCAGAGAGCTCC AG-------------------CAGAGTGGCCCCCGCCGACG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGCACCAGCCCACCCGCATCCCCT CCCCCCCGCAGCCTCCCCTGTGCCTCTTCTCTGGCGTGCTCTCTCGCACCCACTTTCCCC TGCCCCCCCCCCCATCGCTTTGTTGGTGCGGGTGGATGGGCGCACCTCCCCTCCCTTC-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CCCCACCAGC-------TTGTGTGTGTGCGTGCACCCGGC CACGCCACTGCTGCTGCCAGGATTGGTC-------------------------------- -----------------------------------------------CCCACTGCCCTAC CGCCTGACCATTGACAATCGGGCACTTGGCAATGCTGCCATTGCAAGCGGCAGCACCTGC ATGGA-TGCCACAAACCTTGCTCCCCATTGTTCTTGAATGCACAATGA------------ ------------------------------------------------------------ --------------------------------------------TACAAACACACACATG GAACCCACCCCCCCCCCCCCCTGCCCCGTGCTGCCGCCGCTGCTGGCGCGAATGCGCGCA CGG--------------------------------------------------------- ------------------------------------------------------------ ----------------------ACGCCGGCAGCCCTGCCCCCCCCCGCCCCCTCCGCCAG CTGCCACCGCCAGG---------------------------------------------- ------------------------------------------------------------ --------------------GCGGCCGGCGCTGCCGTGCCTCCCTGCACGAAACCCTCCC CCCCGCCCCACCCCCTTCTTGCCCCCACCGCCGGCGTAAGCACATGCAGGAATGCTGCAG CCCTACTCCTGCTGGTACCCCGCCCCAGCCGACGCGCGTGCACCCCGCTGCGCTGCCACG GCTGCTGGCATGCAC--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAGTGAGCACGGATCCCGCTGCCACCACCCCGATGAA GTTTTGGCCGGCACCAGAGTGTTGTGGCCAGCGGACTGGGAACACCTCGGCCCCTCCAGT GCGCAGGTTCCTAACCTCGAGGGGCCAGAGAACAAAGCCGGGGGCCCGGTACCAGCCCCC CAG-----------AGTTAGAGCATGCAGCCCAGGAGTGCTGAGCTGAGCCTTGGCCCCC --------TAAAATCTTCCAGAAACGAAGCCAGTTGACTGAACCCACCTTATACCACAAT CAAACCCCCAAG---------------------------GGCATCAAAGAA--------- ---------GATAAAAGCAAAAAA------------------------------------ -AAAAACAAAAAAAAAAAAACCCATCCAAAGGACAGCAACTTCAGATTGAAGGAACATCA GCCCA------------------------------------------------------- -------------------------------CACAGAAGAA-----CCAGTGCAAGAACT CTG-------------------------------------GCAACTCAA--------AAA GCCA----GAGTGTCT-------------TCTT--ACCT--CCAA---A-CG-------- -------ACT----GCACTAGTTC-------------------CC-CAG---CAATGGTT CTTAACC----------------AGG---CTGAAATGGCTGAAATGACAGAAAT------ ------AGAA------------TTCAGAATATGGAT-AGGAATGAAGATCATTGAGAT-- --TCAGGAGAAAGTT--------------------------AAAACCCAATCC-----AA GGAATCT---------------------------------------------AAGGAATA C-AATAAAA--------------------------------------------------- -TGATACA----------GGAGCTGAAAGATGAA-------------------------- -------------------------------------------ATGGCCATTTTAAGAAA ----------GAAC---------------CAAACTG------ATC---------TGATA- GAGC----TGAAA---------AACTC---ACTACAAGAATTTCATAATACAATCACA-- ---AGTATTAACAGCAGA----------------ATAG--------------------AC C--AAGC------------------TGAGGAAAG-AAT-CTCAG--AGCTCAAAGAC--- -TGGTTCTCTGAAA-T-----AACTCAGTCAG---------ACAAAAATAAA---GAAAA AAAA---ATAAAAAAG-AA---------TGA---ACAAAACCTCC--AAGAAATATGGG- ATTAT--------G---TAAAGAG--ACCAAATCTATGA--C-TCATTGG--CATC---- ----------CCTGAAAGAGAGGGAGAGAAAGCA---AGCAACTTGG---------AAAA CATATTT---GA-----GGATATCATCCAT--GAAAATTTCCCCAACCT----------- ---------CACTAGAGAGGC--CAAC--ATTCAAATTC-----AGGAAATGCAGAGA-A CCCCTGTGA------------GATACTA-TAC--------------AAGAAGACCATCCC C-------A---------------------AGACACATAGTCATCAGATT------CTC- CAAGGTTAAAA---TGAAAA--AAAAAATGT----------------------------- -------------TAAAGGC--AGCTAGAGA---GAAGGGGCAGGT-------------- -----------CAC---CTACAAAGG-GAACCCCA--------------TCAGGCT--AA CAGCAGACCTT-----TCAGCAGAA--ACCCTA-CAAGC------CAG-AAGAGATTG-- -----------GGG-GCCTATA-T-------TCAGCA--TTCT-------------TAAA GAAAA---------------GAAATT--CCA--ACCAAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCAT-AAGCAA-------AG-------- ------------------------G-AGAAATAAGATCCTTTTCAGACAAGC-AAATGCT AAGGGA-ATTCATTACCACCAGAC---CTGCCTTAC-AAGAG------------------ --------------------GTCCTTAAGGG----------------------------- -----------------------------------AGTGC--------------TAAATA TGG----------------------------------------------------AAAGG AAAG---------------ACCATTA---------------------------------- -------------------------------CCAGCCACCACA----------------- ------------------------------------AAAACAC----------------- --------ACTTTAAGTACATA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCATTGACAC-------------------------TATAA A-------------------------------------------------GCAACCACAC ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AATCAAGTCTGCA--------------TA---ATAACCA GCTAA------------------------------------------------------- ------------------------------------------------------------ -------------CAACATG---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------CTGCACATA--TCAATATTAAC-CTTGAAT-------G-T AAAT--GGGCT--AAATGC---CCCAATT----------------AAAAGGC------AC AGAG--TGGCAA----GTTG---------GAT-------AAAG---AAGCAAGACCCAA- ---CTG-------TAT-GCTGTCTT-CAAGAGACCCATCT-CACAT--GCAATGACACCC A-TAGGCTCAAAGTAAAGGGA---T------------GGAGA----A-AAATCTACCAAG C--------------AAATAG------AAAAC---------------------AGAAA-A AAGCAG--GGGT----TGCTATTCTAATTTC-AGACAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAAAGAC-AAAG-AAGGGCAT------TACAT------AAT GGTAAA---GGGTTCAATT------CAACAA---GAAG--------AC-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAACACAGGAGCAC CCAG--ATT-CATAAAGCAAGTTCTTAGAGACCT--AC----AAAGAGA---------CT TAGATAACCAC------ACAATAATAGTGGGAGACTTCAACA----------------CC CCACT------GACAGT-ATTAGACAGATCAT---------------------TGAGGC- -----AGAA-------------AACTAACAAAGATATTCAGGACCTGAAC-TCGACACTT GA------CCAAATGG---ACCTAACAGACATCTACA--GA----ACTCTCCACCCAAAA AC---AACAGAATATACAT------TCTTCTCATCTG-----CA--CAT-GGCACATACT --C----TAAAATTAACCACACAATCGGCCATAAAACAAT-------------------- -CCTCAGCAAATTCAAAAAAA--CTGAAAT----------------CATACCAA------ -CCACACTCTCA---GACCACAGCACAA-TAAAAATAGAAATCAAT-------------- ----------------------------------------------ACTA--------AG --------------AAA-ATCGCTCA---AAACCATACAA----TTACATGGAAA--T-T AAACAACCTG-CTCCTGAA---TG-ACTTTTG--GGTAAACAATGA--AAT--T-AAGGC AGAAATC---------------AAGAAATTCTTT---GAAAC------------------ ------TAATGAGAACAA-AGA------------TACAAC--ATACCAGAATCTC-TGG- GA-----CACAGCTAAAGCAGTG-----------------------------TTAAGAGG GAAG--TTTATAGCACTA----AACAC----CCACATCAAAAAGT---TAGAAAGATCT- --CAAATTAAC-AACCTAA-CATCACACCTA---GAGGAAC--TAGAAAAAC------AA GA-----GCAAACCAACC-------------CCAAAGC--TAGCAGAA-GACAAGAAATA ACC---AAAATCAGA-------------------GCTGAACTG---AA-G-GAAATTGAG ATGCA------AA------------------------------------AAA-CCA---T ACAAAAGATC-A---------ATG----AATCCA-GGAGTTG------GTTTTTTGAAAG AATAAA------------------------------------------------------ --------------------------------TAA-----GATTGATAGACCA---CTAG CTA------GACTAA--TAA------------AGAAA------------------AAAAG A---GAGA-AGATCC-----------------AAATAAA--------CACAA-----TC- ---------AGA-AATGACA--AA----------GGGGA---CATTACCACTGACCCC-A CA-GAAATA--CAAAAAAC-CCTCAG---------AGACTACT--ATGAA---------- -----------CAC---CTCTATGCACACAA---ACTAGAAAACCTAG---AAGAAAT-- GGATAAATTCCT----------GGAAACA---------TAC-----AACCTCCCA----- -AGATTGAACCA---GGAAGAAATTGAATCCCTGAAC----------------------- AGACC------------AA-TAATGAGTTCTAAAATTGAAT-C---------AGTAAT-- -AAAAAGCCTACC------AACCAGAAAAAG---CCCAGGACC--AGATGG--------- ------------ATTCACA-GCTA--AA-------------------TTCTA-------- ----CCAGATGTAT---AAAGAA-GAGCTGG--TA-CCATTC----------CTACTGAA ACTATT----CC---AAAAAATTGAG------GAGGAG-GG-----------ACTCCTCC CTAACTCATTCT-----ATGAGGCC-----AGCAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CTGGC AGA---------------------GAC---ACAACAAAAAA---AGAAAACTTC------ -------------A-GGCCAATAT---CCT----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACCG------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTAATCCA--CCACGAT------------C AAG---TAGGC-TT----------TATCCCT------------GG--GATGCAAGGTTGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--TGTG ---ATTCATCACAT------AAACAG----AACTAAAAACAAAAAC---CACATGA---- -TCATCTCAATA---GATGC---AGAAAAGGCTTTTAATAA---AATTCAACATCCCTT- ---------------CATGT---------T---A--AA-----AACCCTCAAC---AAAC TAGGCATTGAAGGAACAT-----ACTTCAAAATAATAAG--------------------- ------AGCCATCTAT-GACAAA--------CCCACAGC-----------CAACAT--CA TACTGAATGGGCA-----AAA-GCTGGAAGC----ATTC---CCC----TT--GAGAACC AGAACA----AGACAAGG-ATGC--CCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAAGGCATCCAAATAGGA---AGAGAG------GAAGTCAAA--C--------- ------TATCTCTG-TT--T---GCAGA------TGATAT------GATTCTATACCTA- -GAAAACC--CCATAGT---CTCTGCCC---------A---------------AA--AGC TCCTAGATCT---------GA--TAAACAACTTCAGCAAAG--TTT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCATTTC--TA-TACACCAAC---------------AACATCCAAG-----CTG A------------------GAGCCAAATC-AAG----AATACAATCCCATTCACAATAGC CACA------------------AAAAGAATA---------AAA------TACCTAGGAAT ACAGCT--------AA--C-CAGGGAGGTG---A---AAGATCTCT---ACAA-TGAGAA TTACAAAACAC------TGCTC-AAAGAAATCA-GA------------GATG-------- ------------ACAC--AAAC--AAA---TGGA---AA--AACAT---------TCCA- --TGCTC------ATG-GATAGGAAGAATC-A---A---TATT--------------G-- TTAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--AGCAATTTACA-------------------GA---TTCAATGCT---ATT-- ------C-CTATCAAACT--A---------------------CCAATG-AC---ATTCTT ------------------------------------------CACAGAATTAG------- ---------------------AAAAAAACTAT------TTTAAAA---TTCATATGGAAC C-------AAAAAAGAGCCT---AA--ATAGCCAAGGCAATCCTAAGCA---AAAA---A ACA---AAGC--T-------GGA--GGCATCACA---TTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---AAAAACAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAGCCC------AG---AAATAAAG-- -CCAC----------------ACA-------CCTACAA----CCATCT--GATCTTT--- GACAAA--GTTGACAAAAACAAGC--A-------------------ATGGG--GA---AA GG------------ACTCCCTATT--CAATAAATGG---------------TGCTG---- ------G-GATAAC--TGG-CTAGCCA---------------TATGC-AGAAGA---TTG ---------AAACTGGACCCC---TTCCT-----------TACACC--ATA--T---ACA AAAA-TCAACT-CAAGATGG---AT---TAAAGAC---TTAAATGTA--AAACCTAAAAC TAT------------------------AAAAACCCTGGAA---------------GATAA ---CCTA-------------------------GGAAATACCATTCTGGACATAG--GCC- -----CTGGCAAAGATT-----TCATGATGAA-GATGCCA---AAAGCAATTGCAAC--- --AAAAACA---AA----AAT---TGACAAA-TGGGAC----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAT-------------CAACAGAGTAAACAG------------------- ------A-------------CAACCT------ACAGAA--T-GGGAG---AAAATATTT- --GCAAACTATGCAT--------CT-------GACAAAGGTC--------TA--ATATC- ---CAGAATCTATAAG-GA--ACTTAA---ACA------AA--TTAAC------------ ---AAG--------------CAAAAAACA---AAC--AACCCCA-TTAA---AAAGTGGG C--AAA---------GGA--CATGA---AC---AGACACTT------------------- -----TTCAAAAGAA--------GACATAC---AT-GTGGCCAAC--AAGCATATGAAAA AAT----------GCTCAACATCACTA-ATCATTA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACACCAGTCAGAATGGCTATTAT---T A--AAAAG-------TCAAAAA-----ATAACA-GATG--C------------------- ------TGGC-GAGGTTGTA----------GAGAA------------------------- ------------AAGGGAATGCTTAT-ACACTGCTGG--TGGG----------------- ----------AATGT--A-------------AATT---AGTTC----AGCCATTGTGG-- ------AAAGCAGTT--TGGGA--A-TTTCTC--AAAGAACTAAAA--ACAGAACTACC- -ATTT---GA--CCCAGCAATCCCA---------------------TTATTGGG-TATA- --------------TA-CCCAAAGGAA------------TATAAATCA----T------- --------------TCTACCAT--AAAGACACATGC---------ATGCG----TATGTT CATT--GCAGCACTATTCACAA-TAGCAAAGACAT--G--GA--ATCA--ACCTAA---A TGCCCATCA---ATGGTAG-----ACTGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AAGAATGAGATCATGTCCTTT---- ------------------------------------------------------------ --------GCAGCAACATGGATGGAG-C---TGGAGGCCATTATCCTAAGTGA------- ------------------------------------------------ACTAACGCAGGA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAATAC-TG-------- ---CAT---GTTCTCACTTAT----------AAGTGGGAGCCT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAACA-------TTGAGTA---------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------AGGGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AACAGAC-----------------------------------------------A CCG-------GGGCCTACTT----------------GAGGGTGGAGGGTGGGAGAGGG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TGAGGATCGAAAAACT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ACCTATCGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----CTATGCTTATTACCTGGGTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------AAATAATCTGTACACCAAACCCCCGTGACAT----------- ------------------------------------------------------------ ------------------------------------------------------------ -GCAATTT-ACCTATAT------------------------------------------- --------------------------------------------AACAAA---------- -------------------CCTGCACATGTACCCCT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAACCTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ATAAAAGTTAAAAAAAAA------------------------------------------ ------ >L1PA13 ------------------------------------------------------------ ------------------------------------------------------------ ------------GGAGAGGGCAAG-----------------ATGGCCGACTAGATGCAGC CAGGTGGAA---------------------------CAGCTCCCACTG------------ ---------------------------------------AGGGACTGAGATGACTG---- ------------------GCGTGCTCCTAACAGATCTTCAGAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------GGAAGGCACTGAG------AGTGGACGGAG------------G GAAGACACAGAAGCTGGGCTGAAGGGGGAGAAAG---------CTGGGAACCCTGCATGG GGCTACTGCGCACC---------------------------------------------- ---------------------------------------------------GGGACTCAT TCCTGGCCCCCAACGGCTCCGGGGGAATGGGTGA-----GT---TGAACTGGCAAGGAGC AACCTGCTCTCAC---------------------------------------CATGGGCC TCTGGAACCCCGGCAGGAGGAGACCCCTCGACCACCACAGACACTTGAGTTGGC------ ---------------------------------------------AGGGAGAGCTGCTTA GAGAAGTGGTAGGGGCAGCAAGCCAGCTGATGTGGA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCCCAGAGGGTTTGGTGCGGGAGCATCTG TAGTGGAGCATGGCCAGGGACGGCCATCCCCCTAGGCTCGACTTGCTCCCATAGGAGACT TTAGCCCTAGGGGAAC-------------------------------------------- --------------------------------TGTCGGACCTGAACTCTGCAGGGCGGTC TTGCCCATCAGATGGGGCTGGTCTGACCTGAGCACCCCTTGGTCTGCTGGCCTCTCCTGG GGCCCCAGCCTGGCCATGCCTGCTTGCAGGGCAGTCTCGGG---------------TGCC CTGGGGGCCCACACCATAGCTTCTGCGCTGGCGGACCATGCCTGACCAGTGGAGAGCTCC AG-------------------CAGGGCAGCCCCTATGGCCA------------------- ------------------------------------------------------------ ----CGCACCAGCCTGCATGCTCCCTCCCCATACT------------------------- ------------------------------------------------------------ ----------------------------------------GCAGCTTCCCCCGGGCCCAT GGCAACTCCCCACATCACTTTGCTGGTGTGTGTCTGCACGGGCGGGTTTTGCTTTCCTTG CCCCGCCAGCATGCGGGAGTGCAGTCCGCCCC---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------CCCCCCCCCC-------GCCGACCACCATTGCAGACGGAG CCTTGGTGGGCACAGAGCCAGCCAGCCCCGCCCCACCAGTGCCCTGCCCTTGCGCTAACA CTGCACAGAGAACAGCGGATCCTCCCCCACCCTGA------------------------- ------------------GCGACCACTCCTGCTTGCGGGCACAGAGAAGGCACCCAGACC TGTGC-CTGCCAGCACCCCCCCCCCGAGCCAACACCACCTCCAGTGTGACTG-------- ------------------------------------------------------------ --------------------------------------------CGCACACAGTCTCCAG CAGGGGCCCCCTTCCCCCCCCCCCCCCAGCTGCATTG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CCTCTGCCACTGTGGTGAATG CCCGCAGGGAGGCA--------------------------------GGCACCCCGGCACC CGCTAGCACTCTGCTGCAGCTGCTGATCGTGCACCCCACTCCGCTGCTGCTACC------ ------------------------------------------------------------ ------------ACTGCTGCTGGCACGTGCGAATGAGGATGGATCCCGCTGTCACCGCAC TACGAAATGCTTTGGCTGACACCACCCATCGGAGTGTAGTGACCAGCGGTCTGGGAGATC TCCATTGTCCAGGCGCCCCTCGGCCCCCCCAGCGCAGTGGATTCCTAAC----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------CTCGAGGAG-----------CCAGAGAACAAAGTCGG GGCCCAATACAAGTCCCCCAGAGTTAGAGCACGCAGTCCAGGAGTTGGGAGCTGAGCGTT GGCCCCCTAAAATCTTCCAGAAATGAAGCCAGTCAGCTGAATCCACCTTATACCACAATC AAACCCTCAAGGTCATCAAATAGGATAAAAAAAAAAAAAAAACAT--------------- ----------------------------------------------CCAAAGGTCAGC-- ---------------------------------------AACCTCAAAGAT--------- ---------TGAAG---------------------------------------------- -GTAGATAAGCCCACAAAG----------------------------------------- ------------------------------------------------------------ -------------------------------TGAGAAAGAA-----TCAGCACAAGAACC CTG-------------------------------------ACAACTCAA--------AAA GCCA----GAGTGCCT-------------TCTT--TCCT--CCAA---A-TG-------- -------ACC----GCATCACCTC-------------------TC-CAG---CAAGGGTT CTGAACC----------------AGG---CTGAGATGGCTGAAATGACAGAAAT------ ------AGAA------------TTCAGAATATGGAT-AGGAACGAAGATCATTGAGCT-- --ACAGGAGTACATT--------------------------GAAACCCAATCC-----AA GGAAGCT---------------------------------------------AAAAATCA T-GATAAAA--------------------------------------------------- -CAATGCA----------GGAGCTGACAGACAAA-------------------------- -------------------------------------------ATAGCCAGTATAGAAAA ----------GAAT---------------GTAACCA------ACC---------TGATA- GAGC----TGAAA---------AACAC---ACTACAAGAATTTCATAATGCAATCACA-- ---AGTATTAATAGCAGA----------------ATAG--------------------AC C--AAGC------------------AGAGGAAAG-AAT-CTCAG--AGCTTGAAGAC--- -TGGCTTTCTGAAA-T-----AAGACAGTCAG---------ACAAGAATAGA---GAAAA AAGA---ATGAAAAGG-AA---------TGA---ACAAAACCTCC--GAGAAATATGGG- ATTAT--------G---TAAAGAG--ACCAAATCTATGA--C-TCATTGG--TGTC---- ----------CCTGAAAGAGATGGGGAGAATGGA---ACCAACTTGG---------AAAA CATATTT---CA-----GGATATCATCCAT--GAGAACTTCCCCAACCT----------- ---------AGCTAGAGAGGC--CAAC--ATTCAAATTC-----AGGAAATGCAGAGA-A CCCCAGTAA------------GATACTT-CAC--------------AAGAAGATCATCCC C-------A---------------------AGACACATAATCATCAGATT------CTC- CAAGGTCGAAA---TGAAAG--AAAAAATGT----------------------------- -------------TAAAGGC--AGCTAGAGA---GAAAGGTCAGGT-------------- -----------CAC---CTACAAAGG-GAAGCCCA--------------TCAGACT--AA CAGCAGACCTC-----TCAGCAGAA--ACCCTA-CAAGC------CAG-AAGAGATTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAAATT--CCA--ACCCAGAA--------TTT---CATAT CTG-----------GCCAAACTAAGC-----TTCAT-AAGCGA-------AG-------- ------------------------G-AGAAATAAGATCCTTTTCAGACAAGC-AAATGCT GAGGGA-ATTTGTTACCACCAGAC---CTGCCTTAC-AAGAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCAC--------------TAAATA TGG----------------------------------------------------AAAGG AAAG---------------ACCATTA---------------------------------- -------------------------------CCAGCCACTACA----------------- ------------------------------------AAAACAC----------------- --------ACTGAAGTAACACA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCAGTGACAC-------------------------TATAA A-------------------------------------------------GCAACCACAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAACAAGTCTGCA--------------AA---ATAACCA GCTAA------------------------------------------------------- ------------------------------------------------------------ -------------CATCATG---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------CCACACATA--TCAATACTAAC-CTTGAAT-------G-T AAAT--GGGCT--AAATGC---CCCAATT----------------AAAAGAC------AC AGAG--TGGCAA----GCTG---------GAT-------AAAG---AACCAAGACCCAT- ---TGG-------TAT-GCTGTCTT-CAAGAGACCCATCT-CACAT--GCAATGACACAC A-TAGGCTCAAAATAAAGGGA---T------------GGAGA----A-AAATCTACCAAG C--------------AAATGG------AAAAC---------------------AGAAA-A AAGCAG--GGGT----TGCAATCCTAGTTTC-AGACAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAAAGAC-AAAG-AAGGGCAT------TACAT------AAT GGTAAA---GGGTTCAATT------CAACAA---GAAG--------AT-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAACACAGGAGCAC CCAG--ATT-CATAAAGCAAGTTCTTAGAGACCT--TC----AAAGAGA---------CT TAGACTCCCAC------ACAATAATAGTGGGAGACTTTAACA----------------CC CCACT------GACAAT-ATTAGACAGATCAT---------------------TGAGAC- -----AGAA-------------AATTAACAAAGATATTCAGGACCTGAAC-TCAGCACTG GA------TCAAATGG---ACCTGATAGACATCTACA--GA----ACTCTCCACCCAAAA AC---AACAGAATATACAT------TCTTCTCATTGC-----CA--CAT-GGCACATACT --C----TAAAATTGATCACATAATCGGAAGTAAAACACT-------------------- -CCTCAGCAAATGCAAAAGAA--CTGAAAT----------------CATAACAA------ ----ACCTCTCA---GACCACAGCACAA-TCAAATTAGAAATCAAG-------------- ----------------------------------------------ACTA--------AG --------------AAA-TTCACTCA---AAACCATACAA----TTACATGGAAA--T-T GAATAACCTG-CTCCTGAA---TG-ACTTTTG--GGTAAATAATGA--AAT--T-AAGGC AGAAATC---------------AAGAAGTTCTTT---GAAAC------------------ ------TAATGAGAACAA-AGA------------TACAAC--ATACCAGAATCTC-TGG- GA-----CACAGCTAAGGCAGTG-----------------------------TTAAGAGG GAAA--TTTATAGCACTA----AATGC----CCACATCAAAAAGT---TAGAAAGATCT- --CAAGTTAAC-AACCTAA-CATCACAACTA---AAAGAAC--TAGAGAACC------AA GA-----GCAAACAAATC-------------CCAAAGC--TAGCAGAA-GACAAGAAATA ACC---AAAATCAGA-------------------GCTGAACTG---AA-G-GAGATTGAG ACACA------AA------------------------------------AAA-CCA---T TCAAAAGATC-A---------ATA----AATCCA-GGAGCTG------TTTTTTTGAAAA AATTAA------------------------------------------------------ --------------------------------TAA-----AATAGATAGACCA---CTAG CTA------GACTAA--TAA------------AGAAG------------------AAAAG A---GAGA-AGATTC-----------------AAATAAA--------CACAA-----TC- ---------AGA-AATGACA--AG----------GGGGA---TATTACCACTGACCCC-A CA-GAAATA--CAAACAAC-CATCAG---------AGAATATT--ATGAA---------- -----------CAC---CTCTATGCACATAA---ACTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----ACCCTCCCA----- -AGACTGAACCA---GGAAGAAATTGAATCCCTGAAC----------------------- AGACC------------AA-TAATGAGCTCTGAAATTGAGT-C---------AGTAAT-- -AAATAGCCTACC------AACCAAAAAAAG---CCCAGGACC--AGATGG--------- ------------ATTCACA-GCTG--AA-------------------TTCTA-------- ----CCAGATGTAC---AAAGAA-GAGCTGG--TA-CCATTC----------CTGCTGAA ACTATT----CC---AAAAAATTGAG------GAGGAG-GG-----------ACTCCTCC CTAACTCATTCT-----ATGAGGCC-----AGCAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CTGGC AGA---------------------GAC---ACAACAAAAAA---AGAAAACTTC------ -------------A-GGCCAATAT---CCT----TGATGAACATTGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT GGC-AAACCG------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTTATCCA--CCATGAT------------C AAG---TAGGC-TT----------TATCCCT------------GG--GATGCAAGGTTGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--TGTG ---ATTCATCACAT------AAACAG----AACTAAAGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCTTTTGATAA---AATTCAACACCCCTT- ---------------CATGT---------T---A--AA-----AACTCTCAAT---AAAC TAGGTATTGAAGGAACAT-----ACCTCAAAATAATAAG--------------------- ------AGCCATCTAT-GACAAA--------CCCACAGC-----------CAACAT--CA TACTGAATGGGCA-----AAA-GCTGGAAGC----ATTC---CCC----TT--GAAAACC GGCACA----AGACAAGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ATT---GGAAGTCCTGGCCAGGGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAGGGCATCCAAATAGGA---AGAGAG------GAAGTCAAA--C--------- ------TATCCCTG-TT--T---GCAGA------TGACAT------GATCCTATATCTA- -GAAAACC--CCATAGT---CTCAGCCC---------A---------------AA--AGC TCCTTAAGCT---------GA--TAAACAACTTCAGCAAAG--TCT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- GCAAAAAT----CACT-------------------------------------------- -----AGCATTCC--TA-TACACCAAC---------------AACAGTCAAG-----CCG A------------------GAGCCAAATC-AGG----AATGCAATCCCATTCACAATTGC CACA------------------AAAAGAATA---------AAA------TACCTAGGAAT ACAGCT--------AA--C-CAGGGAGGTG---A---AAGATCTCT---ACAA-GGAGAA CTACAAAACAC------TGCTC-AAAGAAATCA-GA------------GATG-------- ------------ACAC--AAAC--AAA---TGGA---AA--AACAT---------TCCA- --TGCTC------ATG-GATAGGAAGAATC-A---A---TATT--------------G-- TTAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--AGCAATTTATA-------------------GA---TTCAATGCT---ATT-- ------C-CTATTAAACT--A---------------------CCATTG-AC---ATTCTT ------------------------------------------CACAGAACTAG------- ----------------------AAAAAACTAT------TTTAAAA---TTCATATGGAAC C-------AAAAAAGAGCCC---GA--ATAGCCAAGGCAATCCTAAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACG---CTACCTGACTTCAAACT-----A TACTAC-------------------------AG---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---AAAAACAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAGG-- -CCAC----------------ACA-------CCTACAA----CTATCT--GATCTTT--- GACAAA--CCTGACAAAAACAAGC--A-------------------ATGGG--GA---AA GG------------ATTCCCTATT--CAATAAATGG---------------TGCTG---- ------G-GATAAC--TGG-CTAGCCA---------------TATGC-AGAAGA---TTG ---------AAACTGGACCCC---TTCCT-----------TACACC--ATA--T---ACA AAAA-TTAACT-CAAGATGG---AT---TAAAGAC---TTAAATGTA--AAACCCAAAAC TAT------------------------AAAAACCCTGGAA---------------GACAA ---CCTA-------------------------GGCAATACCATTCTGGACATAG--GAA- -----CGGGCAAAGATT-----TCATGACAAA-GACACCA---AAAGCAATTGCAAC--- --AAAAGCA---AA----AAT---TGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAT-------------CAACAGAGTAAACAG------------------- ------A-------------CAACCT------ACAGAA--T-GGGAG---AAAATTTTT- --GCAAACTATGCAT--------CT-------GACAAAGGTC--------TA--ATATC- ---CAGCATCTATAAG-GA--ACTTAA---ACA------AA--TTTAC------------ --------------------AAGAAAAAA---AAC--AACCCCA-TTAA---AAAGTGGG C--AAA---------GGA--CATGA---AC---AGACACTT------------------- -----TTCAAAAGAA--------GACATAC---AT-GTGGCCAAC--AATCATATGAAAA AAA----------GCTCAACATCACTG-ATCATTA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACACCAGTCAGAATGGCTATTAT---T A--AAAAG-------TCAAAAA-----ATAACA-GATG--C------------------- ------TGGG-AAGGTTGTG----------GAGAA------------------------- ------------AAAGGAAAACTTAT-ACACTGTTGG--TGGG----------------- ----------AGTGT--A-------------AATT---AGTTC----AACCATTGTGG-- ------AAGACAGTG--TGGCA--A-TTCCTC--AAAGACCTAAAA--ACAGAAATACC- -ATTT---GA--CCCAGCAATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAA------------TATAAATCA----T------- --------------TCTATTAT--AAAGACACATGC---------ACATG----TATGTT CATT--GCAGCACTATTCACAA-TAGCAAAGACAT--G--GA--ATCA--ACCTAA---A TGCCCATCA---ATGGTAG-----ACTGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AAGAATGAGATCATGTCCTTT---- ------------------------------------------------------------ --------GCAGGAACATGGATGGAG-C---TGGAGGCCATTATCCTTAGCAA------- ------------------------------------------------ACTAATGCAGGA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAATAC-CG-------- ---CAT---GTTCTCACTTAT----------AAGTGGGCT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAATG-------ATGAGAA---------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAT----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GGGGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AACACAC-----------------------------------------------A CTG-------GGGCCTATTG----------------GAGGGTGGAGGGTGGGAGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GAGGATCAGGAAAAAT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AACTAATGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----CTAGGCTTAATACCTGGGTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ATGAAATAATCTGTACAACAAACCCCCATGAC------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACAAGTTTACCTATAT------------------------------------------- --------------------------------------------AACAAA---------- -------------------CCTGCACATGTACCCCT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAACTTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------ATAAAAGTAAAATAAA---------------------------------- ------ >L1PREC2 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAG-----------------ATGGCTGACTAGACGCAGC CAGGAGGAA---------------------------CATCTCCCACCGAC---------- ---------------------------------------GGGACATCGGGAAGACT---- -----------------GGCGCACTCCTAGCAGATCTTCAGAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------GGAAGGCATTGAG------AGTGGATGGAG-------GGAAGA CACAGATGGCTGA---------AGGGGGAGGAAG---------CTGGGAACCCTGCATGG GGCTACCGCGCACC---------------------------------------------- ---------------------------------------------------AGGACTCGT TCCTGGCCCCCAGTGACTCCTGCGGAAGGGGTGA-----GT---TGAACAGGCAAGGAGC AACCTGCTCTCAC---------------------------------------CATGGGCC TCTGGAATCCCGGCAGGAGGAGACCCCTTGACCACCATGGACACTTGAGTTGGC------ ---------------------------------------------AGGGAGAGCTGCTTA GAGAAGTGGTAGGGGCAGAACTCCAGCCGGTGCAGA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCCCAGAGGGTTTGGTGTGGGAGCATCTG TAGTGGAGCATGGCCAGGGATGCCCATCCCCCTAGGCTCAACTTGCTCCCATAGGAGACT TTAGCCCTAGGGGAAC-------------------------------------------- --------------------------------TGTCGGACCTGAACTCTGCAGGGCGGTC TTGCCCATGAGACGGGGCCAGTCTGACCTGAGCACCCCTTAGTCTGCTGGCCTCTCCTGG GGCCCCAGCCTGGCCATGCCTGCTTGCAGTGCAGCCCCCAGGTACCTCCTGGGGGCCCGC ATCATAGCTCCTGCG------------CTGGTGGACTGTGCCTGACTGGCAGAGTGCTCC AG-------------------CAGAGTGGCCACCCTTGCCA------------------- ------------------------------------------------------------ ----CTCCGCAGCCTCCCCTGCCCACGCCCTCCCTCCCCT-------------------- ------------------------------------------------------------ -------GCAGCCTCCCCTGTGCCACTTTGCCTGCATGCACCCACCCACGGCCACCCC-- ---------CCACATCGCTTTGCCGGCGCATGTGTGCACGGGCGGACCTTGCCTTCCCTT CCCTGCCAGCGCGTGTGTGCACATGCACCCTGCCATGCCACTGCTGCTGGCGTGAGTCCC CTCCCCCCCTCCCCCCCCCCCTGCCATTGTCGTTGGAGCATTGGCGGGCATGGAGCCCGC CAGCCCTGCCCCCACCAGCGCCCTGCCCCTGCGCCAACACTGCCACCAGCGTGAAACTAG GCATGGAGAACAGCGGACC-TGCCCCCACC-------CTGAGCGGCCACCGCCACCCGCG TGAACGTGCACAGAGGGTACACACAGTC-------------------------------- ---------------CTGTGCCCACCAGCACCCTG------------------------- -------------CCCCCATGCTAACACCACCACCAGTGAACATGCACACACAGTTGCTG GCAGG-GGCCCCCCCCCCCCCCCCCCGAGCCATGCTGCCACCGCCGCT------------ ------------------------------------------------------------ --------------------------------------------GCTGTGAATGCCTGCA CGGA------GGCCGGCACCCTAGCACCTACTAGCACCCTGCCGCAGCTAATGAGTGTGC A----------------------------------------------------------- -----------------------------------------------------------C CCCGC-----------------CATGCTGCTG-------CTGCTGCTGCTGCTGGCATGT GTGAACGAGGATGG--------------------------------ATCCCGCTGCCACT GC------------CCTATGAAGTGCTTTGG----------------------------- -----------------------CTGGCACCACCCATTGGAGTGTTGTGACCAGCGGTCT GGGAGCACCTTGGCCCCTCCAGTGCAGCAGGTTCCTAACCTTGAGGAGCCAGAGAACAAA GCCAGGGCCCAATACCAGTCCCCCAGAGTTAGAGC----ATGCAGTCCAGGAGTCCTGAG CTGAGCCTTGGCCCCCTAAAATCTTCA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAAATGAAG-----------CCAGTTGACTGAACCCA CCT--------------------------------------------------------- --------------------------TATACCACAATCAAACCCCCA------------- --A-----------GGTCATCAAATAGGATAAAAGAAAAAAAAACCAT------------ ----------------------------------------------CCAAAGGACAGC-- ---------------------------------------AACTTCAAAGAT--------- ---------TGAAG---------------------------------------------- -GAACATCAGCC------------------------------------------------ ------------------------------------------------------------ -------------------------------CACAAAGAAA-----CTCTTG-------- ----------------------------------------ACAACTCAA--------AAA GCCA----GAGTGTCT-------------TCTT--TCCT--CCAA---A-TG-------- -------ACC----ACACTAGTTC-------------------TC-CAG---CAAGGGTT CTTAACC----------------AGG---CTGAGATGGCTGAAATGACAGAAAT------ ------AGAA------------TTCAGAATATGGAT-AGGAATGAAGATCATCAAGAT-- --TCAGGAGAATGTT--------------------------GAAACCCAATCT-----AA GGAAGCT---------------------------------------------AAGAATCA C-AATAAAA--------------------------------------------------- -TGATACA----------GGAGCTGACAGACAAA-------------------------- -------------------------------------------ATAGCCAGTATAGAAAA ----------GAAT---------------GTAACTA------ACC---------TGATA- GAGC----TGAAA---------AACAC---ACTACAAGAATTTCATAATGCAATCACA-- ---AGTATTAACAGCAGA----------------ATAG--------------------AC C--AAGC------------------TGAGGAAAG-AAT-CTCAG--AGCTTGAAGAC--- -TGGCTTTCTGAAA-T-----AAGACAGTCAG---------ACAAGAATAAA---GAAAA AAGA---ATAAAAAGG-AA---------CAA---ACAAAACCTCC--AAGAAATATGGG- ATTAT--------G---TAAAGAG--ACCAAATCTATGA--C-TCATTGG--CATC---- ----------CCTGAAAGAGATGGGGAGAATGGA---AGCAACTTGG---------AAAA CATATTT---CA-----GGATATCATCCAT--GAGAACTTCCCCAACCT----------- ---------AGCTAGAGAGGC--CAAC--ATTCAAATTC-----AGGAAATGCAGAGA-A CCCCCACAA------------GATACTT-CAC--------------AAGAAGATCATCCC C-------A---------------------AGACACATAATCATCAGATT------CTC- CAAGGTTGAAA---TGAAAG--AAAAAATGT----------------------------- -------------TAAAGGC--AGCTAGAGA---GAAAGGACAGGT-------------- -----------CAC---CTACAAAGG-GAAGCCCA--------------TCAGACT--AA CAGTAGACCTC-----TCAGCAGAA--ACCCTA-CAAGC------CAG-AAGAGATTG-- -----------GGG-GCCTATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAAATT--CCA--ACCAAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCAT-AAGTAA-------AG-------- ------------------------G-AGAAATAAGATCCTTTTCAGACAAGC-AAATGCT GAGGGA-ATTTGTTACCACCAGAC---CTGCCTTAC-AAGAG------------------ --------------------CTCCTGAAAGA----------------------------- -----------------------------------AGCAC--------------TAAATA TGG----------------------------------------------------AAAGG AAAG---------------ACCATTA---------------------------------- -------------------------------CCAGCCACTACA----------------- ------------------------------------AAAACAC----------------- --------ACTTTAAGTA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------CACA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCAGTGACAC-------------------------TATAA A-------------------------------------------------GCAACCACAC ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAACAAGTCTGCA--------------TA---ATAACCA GCTAA------------------------------------------------------- ------------------------------------------------------------ -------------CAACATG---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------CCACACATA--TCAATACTAAC-CTTGAAT-------G-T AAAT--GGGCT--AAATGC---CCCAATT----------------AAAAGGC------AC AGAG--TGGCAA----GCTG---------GAT-------AAAA---AAGCAAGACCCAA- ---TGG-------TAT-GCTGTCTT-CAAGAGACCCATCT-CACAT--GCAATGACACCC A-TAGGCTCAAAATAAAGGGA---T------------GGAGA----A-AAATCTACCAAG C--------------AAATGG------AAAAC---------------------AGAAA-A AAGCAG--GGGT----TGCAATCCTAATTTC-AGACAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAAAGAC-AAAG-AAGGGCAT------TACAT------AAT GGTAAA---GGGTTCAATT------CAACAA---GAAG--------AC-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAACACAGGAGCAC CCAG--ATT-CATAAAGCAAGTTCTTAGAGACCT--AC----AAAGAGA---------CT TAGACTCCCAC------ACAATAATAGTGGGAGACTTCAACA----------------CT CCACT------GACAGT-ATTAGACAGATCAT---------------------TGAGGC- -----AGAA-------------AATTAACAAAGATATTCAGGACCTGAAC-TCAACATTG GA------CCAAATGG---ATCTGATAGACCTCTACA--GA----ACTCTCCACCCCAAA AC---AACAGAATATACAT------TCTTCTCATTGC-----CA--CAT-GGCACATACT --C----TAAAATCGACCACACAATTGGACATAAAACAAT-------------------- -CCTCAGCAAATGCAAAAGAA--CTGAAAT----------------CATACCAA------ -ACACACTCTCA---GACCACAGCACAA-TAAAAATAGAAATCAAG-------------- ----------------------------------------------ACTA--------AG --------------AAA-ATCACTCA---AAACCATACAA----TTACATGGAAA--T-T AAACAACCTG-CTCCTGAA---TG-ACTTTTG--GGTAAATAATGA--AAT--T-AAGGC AGAAATC---------------AAGAAGTTCTTT---GAAAC------------------ ------TAATGAGAACAA-AGA------------TACAAC--ATACCAGAATCTC-TGG- GA-----CACAGCTAAGGCAGTG-----------------------------TTAAGAGG GAAA--TTTATAGCACTA----AATGC----CCACATCAAAAAGT---TAGAAAGATCT- --CAAATTAAC-AACCTAA-CATCACAACTA---AAAGAAC--TAGAGAAGC------AA GA-----GCAAACCAACC-------------CCAAAGC--TAGCAGAA-GACAAGAAATA ACC---AAAATCAGA-------------------GCTGAACTG---AA-G-GAGATTGAG ACACA------AA------------------------------------AAA-CCA---T TCAAAAATTA-----------AAA----AAACCAAGGAGTTG------TTTTTTTGAAAA AATTAA------------------------------------------------------ --------------------------------TAA-----GATAGATAGGCCA---CTAG CTA------GACTAA--TAA------------AGAAG------------------AAAAG A---GAGA-AGATCC-----------------AAATAAA--------CACAA-----TT- ---------AGA-AATGACA--AA----------GGGGA---TGTTACCACTGACCCC-A CA-GAAATA--CAAATAAC-CATCAG---------AGACTACT--ATGAA---------- -----------CAC---CTCTATGCACACAA---ACTAGAAAACCTAG---AAGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----ACCCTCCCA----- -AGACTGAACCA---GGAAGAAATTGAATCCCTGAAC----------------------- AGACC------------AA-TAATGAGCTCTGAAATTGAAT-C---------AGTAAT-- -AAATAGCCTACC------AACCAAAAAAAG---CCCAGGACC--AGATGG--------- ------------ATTCACA-GCCA--AA-------------------TTCTA-------- ----CCAGATGTAC---AAAGAA-GAGCTGG--TA-CCATTC----------CTACTGAA ACTATT----CC---AAAAAATTGAG------GAGGAG-GG-----------ACTCCTCC CCAACTCATTCT-----ATGAGGCC-----AGCAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CTGGC AGA---------------------GAC---ACAACAAAAAA---AGAAAACTTC------ -------------A-GGCCAATAT---CCT----TGATGAACATTGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACCA------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTAATCCA--CCATGAT------------C AAG---TAGGC-TT----------TATCCCT------------GG--GATGCAAGGTTGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--TGTG ---ATTCATCACAT------AAACAG----AACTAAAGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCTTTCAATAA---AATTCAACATCCCTT- ---------------CATGT---------T---A--AA-----AACTCTCAAT---AAAC TAGGTATTGAAGGAACAT-----ACCTCAAAATAATAAG--------------------- ------AGCCATCTAT-GACAAA--------CCCACAGC-----------CAACAT--CA TACTGAATGGGCA-----AAA-GCTGGAAGC----ATTC---CCC----TT--GAAAACT GGCACA----AGACAAGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ATT---GGAAGTCCTGGCCAGAGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAGGGCATCCAAATAGGA---AGAGAG------GAAGTCAAA--C--------- ------TATCCCTG-TT--T---GCAGA------TGACAT------GATTCTATATCTA- -GAAAACC--CCATAGT---CTCAGCCC---------A---------------AA--AGC TCCTTCAGCT---------GA--TAAACAACTTCAGCAAAG--TTT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- ACAAAAAT----CACT-------------------------------------------- -----AGCATTCC--TA-TACACCAAC---------------AACAGCCAAG-----CCG A------------------GAGCCAAATC-AGG----AATGCAATCCCATTCACAATTGC CACA------------------AAAAGAATA---------AAA------TACCTAGGAAT ACAGCT--------AA--C-CAGGGAGGTG---A---AAGATCTCT---ACAA-TGAGAA TTACAAAACAC------TGCTC-AAAGAAATCA-GA------------GATG-------- ------------ACAC--AAAC--AAA---TGGA---AA--AACAT---------TCCA- --TGCTC------ATG-GATAGGAAGAATC-A---A---TATC--------------A-- TTAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--AGCAATTTACA-------------------GA---TTCAATGCT---ATT-- ------C-CTATCAAACT--A---------------------CCAATG-AC---ATTCTT ------------------------------------------CACAGAACTAG------- ----------------------AAAAAACTAT------TTTAAAA---TTCATATGGAAC C-------AAAAAAGAGCCC---AA--ATAGCCAAGGCAATCCTAAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACA---TTACCTGACTTCAAACT-----A TACTAC-------------------------AG---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---AAAAACAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAGCCC------AG---AAATAAGG-- -CCAC----------------ACA-------CCTACAA----CCATCT--GATCTTT--- GACAAA--GCTGACAAAAACAAGC--A-------------------ATGGG--GA---AA GG------------ACTCCCTATT--CAATAAATGG---------------TGCTG---- ------G-GATAAC--TGG-CTAGCCA---------------TATGC-AGAAGA---TTG ---------AAACTGGACCCC---TTCCT-----------TACACC--ATA--T---ACA AAAA-TCAACT-CAAGATGG---AT---TAAAGAC---TTAAATGTA--AAACCCAAAAC TAT------------------------AAAAACCCTGGAA---------------GACAA ---CCTA------G------------------G-CAATACCATTCTGGACATAG--GAA- -----CTGGCAAAGATT-----TCATGACGAA-GACGCCA---AAAGCAATTGCAAC--- --AAAAGCA---AA----AAT---TGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAT-------------CAACAGAGTAAACAG------------------- ------A-------------CAACCT------ACAGAA--T-GGGAG---AAAATATTT- --GCAAACTATGCAT--------CT-------GACAAAGGTC--------TA--ATATC- ---CAGCATCTATAAG-GA--ACTTAA---ACA------AA--TTTAC------------ --------------------AA--AAACA---------ACCCCA-TTAA---AAAGTGGG C--AAA---------GGA--CATGA---AC---AGACACTT------------------- -----TTCAAAAGAA--------GACATAC---AT-GTGGCCAAC--AAGCATATGAAAA AAA----------GCTCAATATCACTG-ATCATTA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACACCAGTCAGAATGGCTATTAT---T A--AAAAG-------TCAAAAA-----ATAACA-GATG--C------------------- ------TGGC-GAGGTTGTG----------GAGAA------------------------- ------------AAAGG----------ACACTGTTGG--TGGG----------------- ----------AGTGT--A-------------AATT---AGTTC----AACCATTGTGG-- ------AAAGCAGTG--TGGCA--A-TTCCTC--AAAGAGCTAAAA--ACAGAACTACC- -ATTT---GA--CCCAGCAATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAA------------TATAAATTA----T------- --------------TCTACCAT--AAAGACACATGC---------ACGTG----TATGTT CATT--GCAGCACTATTCACAA-TAGCAAAGACAT--G--GA--ATCA--ACCTAA---A TGCCCATCA---ATGGTAG-----ACTGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AAGAATGAGATCATGTCCTTT---- ------------------------------------------------------------ --------GCAGGAACATGGATGGAG-C---TGGAGGCCATTATCCTTAGCAA------- ------------------------------------------------ACTAACGCAGGA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAATAC-CA-------- ---CAT---GTTCTCACTTAT----------AAGTGGGAGCCT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAATG-------ATGAGAA---------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GGGGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AACAGAC-----------------------------------------------A CTG-------GGGCCTACCT----------------GAGGGTGGAGGGTGGGAGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GAGGAGCAGAAAAAAAT------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AACTATTGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----CTAGGCTTAGTACCTGGGTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ACGAAATAATCTGTACAACAAACCCCCATGAC------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACGAGTTTACCTATAT------------------------------------------- --------------------------------------------AACAAA---------- -------------------CCTGCACATGTACCCCT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAACCTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------ATAAAAGTTTA--------------------------------------- ------ >L1MC5A ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TGGGGAAAAA-----ACAGAGCAGAAAAG CTG-------------------------------------GAAATTCTA--------AAA AGCA----GAACGCCT-------------CTCC--TTCT--CCAA---A-GG-------- -------AAC----ACAGTTCCTC-------------------AC-CAG---CAATGCAA CAAAAGT----GGTTCTTAAAAGAGA---TTGACATTGACGAATTGACAGAAGT------ ------AGGC------------TTCAGAAGATGGAT-AATAAGAAAGTACATCAAGAT-- --ACAGGAGAAAGTT--------------------------GAAACCCAATGC-----AA AGAAATT----------------------------------------------AAAAAAT TGAATAAAA--------------------------------------------------- -ATTTAGA----------TGAATTTATAACTAAA-------------------------- -------------------------------------------ATAACCATTTTAGAGAA ----------GAAC---------------CAAAATG------AAC---------TTCTG- AAAC----TGAAA---------GACAC---AGCTCGAGAAGTACATAATACAGTCAGA-- ---AACTTTAACAACAGA----------------CAAG--------------------AC C--AAGT------------------AGAAGAAAG-AAT-TTCAG--AGATCGAAGAT--- -AAAACTTATAAAA-T-----AAAGCAAGAAG---------ACAAGTTTAAA---AAAAA AAGA---ATAAAAAGA-AA---------TGA---ACAAAGCCTCC--ATGAAATATGGG- ACTAT--------GTGCTAAAAAG--ACCAAACCTACGT--T-TGATTGG--TGTT---- ----------CCTGAGAGAGAAAGGGAGAATGTA---AAAAATTTAG---------AAAA CATATTT---AA-----GGATATAATCCAT--GAAAAGTTCCCTAATCT----------- ---------TGCAAGAGAGGT--CGAC--ATCCAAATTC-----AAGAAATACAGAGA-A TCCCACAGA------------GACTCCT-ATC--------------AAAAATAGTCACTC C-------A---------------------AGGCAACTAATTATCAAATT------CCC- CAAAGTTAAAA---TGAAGG--AAAAAATTT----------------------------- -------------TAAGAGC--AGTAAGAGA---AAAGGGTCAGGT-------------- -----------AAC---CTATAAAGG-AAAACCTA--------------TCAGACT--AA CAGCAGATCTC-----TCAGCAGAA--ACCCTA-CAAAC------CAG-AAGAGAATG-- -----------GGG-TGCTATC-T-------TTAGTC--TCCT-------------TAAA GAAAA---------------AAATTA--TCA--GCCAAGAA--------TTT---TATAT CCA-----------GCAAAACTAAGC-----TTCAT-AAGTAA-------AG-------- ------------------------G-AGAAATAAAGTCTTTTTCAGACAAGC-AAATGCT GAGAGA-ATTTGTCACTACCAGAC---CTGCCCTAC-AAGAA------------------ --------------------CTGCTAAAGGG----------------------------- -----------------------------------AGTTC--------------TAAATA TGG----------------------------------------------------AAATG AAAG---------------ACCGATA---------------------------------- -------------------------------CCAGCTACTACA----------------- ------------------------------------AAAACAT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- -------------------------------------------------------TAAAA AGTCTCTTTATGAA------------------------------------ACAAGTATAA CATTTATACC-TAATCCTGATAAAGAAAA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AAAAAAGAGC ATATCCCTTTTGCATATAAGAATAAATTACAAAATTAAAAAAAAAATAATAA-------- ------------------------------------------------------------ ---------------------AAAATAAATTTAA--------------ATAATATAAACA AAAAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------ATATGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCACACATA--ACAATATTAAC-CTTAAAT-------G-T AAAT--GGGCT--AAATGC---CCCAATT----------------AAAAGAC------AC AGAC--TGGCAA----AATG---------GAT-------AAAG---AGTCAAGACCCAT- ---CGG-------TGT-GCTGTCTT-CAAGAGACCCATCT-CACAT--GCAGAGACACAC A-TAGGCTCAAAATAAAGGGA---T------------GGAGG----A-AGATCTACCAAG C--------------AAATGG------AAAAC---------------------AAAAA-A AAGCAG--GGGT----TGCAATTCTAGTCTC-TGATAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAAAGAC-AAAG-AAGGGCAT------TACAT------AAT GGTAAA---GGGATCAATT------CAACAA---GAAG--------AG-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAATACAGGAGCAC CCAG--ATT-CATAAAGCAAGTTCTTAGAGACCT--AC----AAAGAGA---------CT TAGACTCCCAC------ACAATAATAATGGGAGACTTTAACA----------------CC CCACT------GACAAT-ATTAGACAGATCAT---------------------CGAGAC- -----AGAA-------------AATTAACAAAGATATTCAGGACTTGAAC-TCAGCTCTG GA------CCAAGTGG---ACCTAATAGACATCTACA--GA----ACTCTCCACCCAAAA AC---AACAGAATATACAT------TCTTCTCATCAG-----CA--CAT-CGCACTTATT --C----TAAAATTGACCACATAATTGGAAGTAAAACAAT-------------------- -CCTCAGCAAATGTAAAATAA--CAGAAAT----------------CATAACAA------ -GCAGTCTCTCA---GACCACAGTGCAA-TCAAATTAGAACTCAAG-------------- ----------------------------------------------ATTA--------AG --------------AAA-CTCACTCA---AAACCACACAA----CTACATGGAAA--T-T GAACAACCTG-CTCCTGAA---TG-ACTACTG--GGTAAATAACGA--AAT--T-AAGGC AGAAATA---------------AAGAAGTTCTTT---GAAAC------------------ ------CAATGAGAACAA-AGA------------CACAAC--GTACCAGAATCTC-TGG- GA-----CACAGCTAAAGCAGTG-----------------------------TTTAGAGG GAAA--TTTATAGCACTA----AATGC----CCACATCAAAAAGC---TAGAAAGATCT- --CAAATTAAC-AACCTAA-CATCACAATTA---AAAGAAC--TAGAGAAGC------AA GA-----GCAAACAAATT-------------CAAAAGC--TAGCAGAA-GACAAGAAATA ACT---AAGATCAGA-------------------GCAGAACTG---AA-G-GAAATAGAG ACACA------AA------------------------------------AAA-CCC---T TCAAAAAATA-----------ATG----AAATCAAGAAGTTG------GTTTTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATTGATAGACCA---CTAG CTA------GACTAA--TAA------------AGAAG------------------AAAAG A---GAGA-AGAATC-----------------AAATAAA--------CACAA-----TA- ---------AGA-AATGATA--AA----------GGGGA---TATCACCACTGATCCC-A CA-GAAATA--CAAACTAC-CATCAG---------AGAATACT--ATAAA---------- -----------CAC---CTCTATGCAAATAA---ACTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------GGAAACA---------TAC-----ACCCTCCCA----- -AGACTAAACCA---GGAAGAAATTGAATCCCTGAAT----------------------- AGACC------------AA-TAACAAGTTCTGAAATTGAGG-C---------AGTAAT-- -TAATAGCCTACC------AACCAAAAAAAG---CCCAGGACC--AGATGG--------- ------------ATTCACA-GCCG--AA-------------------TTCTA-------- ----CCAGAGGTAC---AAAGAA-GAGCTGG--TA-CCATTC----------CTTCTGAA ACTATT----CC---AAACAATAGAA------AAAGAG-GG-----------ACTCCTCC CTAACTCATTTT-----ATGAGGCC-----AGCAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CTGGC AGA---------------------GAT---ACAAACAAAAA---AGAAAATTTC------ -------------A-GGCCAATAT---CCC----TGATGAACATCGAT------------ ------------GCAAAAATCC-TCA--------------------A----TAAAATACT GGC-AAACCA------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTTATCCA--CCACGAT------------C AAG---TTGGC-TT----------CATCCCT------------GG--GATGCAAGGTTGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--TGTA ---ATTCATCACAT------AAACAG----AACTAAAGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCCTTTGACAA---AATTCAACATCCCTT- ---------------CATGA---------T---A--AA-----AACTCTCAAT---AAAC TAGGTATTGAAGGAACAT-----ACCTCAAAATAATAAG--------------------- ------AGCCATCTAT-GACAAA--------CCCACAGC-----------CAATAT--CA TACTGAATGGGCA-----AAA-ACTGGAAGC----ATTC---CCT----TT--GAAAACT GGAACA----AGACAAGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ATT---GGAAGTTCTGGCCAGGGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAGGGTATTCAAATAGGA---AAAGAG------GAAGTCAAA--T--------- ------TATCCCTG-TT--T---GCAGA------TGACAT------GATTGTATATCTA- -GAAAACC--CCATCGT---CTCAGCCC---------A---------------AA--ATC TCCTTAAGCT---------GA--TAAGCAACTTCAGCAAAG--TCT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- GCAAAAAT----CACA-------------------------------------------- -----AGCATTCC--TA-TACACCAAT---------------AACAGACAAA-----CAG A------------------GAGCCAAATC-ATG----AGTGAACTCCCATTCACAATTGC TACA------------------AAGAGAATA---------AAA------TACCTAGGAAT ACAACT--------TA--C-AAGGGATGTG---A---AGGACCTCT---TCAA-GGAGAA CTACAAACCAC------TGCTC-AAGGAAATAA-GA------------GAAG-------- ------------ACAC--AAAC--AAA---TGGA---AA--AACAT---------TCCA- --TGCTC------ATG-GATAGGAAGAATC-A---A---TATC--------------G-- TGAAAATG-----------------------------------------GCCAT--ACTA CCC-AA--AGTAATTTATA-------------------GA---TTCAATGCT---ATC-- ------C-CCATCAAACT--A---------------------CCAATG-AC---TTTCTT ------------------------------------------CACAGAACTGG------- ----------------------AAAAAACTAT------TTTAAAA---TTCATATGGAAC C-------AAAAAAGAGCCC---AC--ATAGCCAAGACAATCCTAAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACG---TTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---CAAAACAGACA--- ---TATAGAC--CA---ATGG-AACAGAATAGAGACCTC------AG---AAATAACA-- -TCAC----------------ACA-------TCTACAA----CCATCT--GATCTTT--- GACAAA--CCTGACAAAAACAAAC--A-------------------ATGGG--GA---AA GG------------ATTCCCTATT--TAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-CTAGCCA---------------TATGC-AGAAAA---CTG ---------AAACTGGACCCC---TTCCT-----------TACACC--TTA--T---ACA AAAA-TTAACT-CAAGATGG---AT---TAAAGAC---TTAAATGTA--AGACCTAAAAC CAT------------------------AAAAACCCTAGAA---------------GAAAA ---CCTA-------------------------GGCAATACCATTCAGAACATAG--GCA- -----TGGGCAAAGACT-----TCATGACAAA-AACACCA---AAAGCAATGGCAAC--- --AAAAGCA---AA----AAT---TGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAT-------------CATCAGAGTGAACAG------------------- ------A-------------CAACCT------ACAGAA--T-GGGAG---AAAATTTTT- --GCAATCTATCCAT--------CT-------GACAAAGGGC--------TA--ATATC- ---CAGAATCTACAAA-GA--ACTTAA---ACA------AA--TTTAC------------ ---AAG--------------AAAAAAACA---AAC--AACCCCA-TCAA---AAAGTGGG C--AAA---------GGA--TACGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATTT---AT-GCAGCCAAC--AAACATATGAAAA AAT----------GCTCATCATCACTG-GTCATTA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACACCAGTTAGAATGGCAATCAT---T A--AAAAG-------TCAGAAA-----ACAACA-GATG--C------------------- ------TGGA-GAGGATGTG----------GAGAA------------------------- ------------ATAGGAACACTTTT-ACACTGTTGG--TGGG----------------- ----------AGTGT--A-------------AATT---AGTTC----AACCATTGTGG-- ------AAGACAGTG--TGGTG--A-TTCCTC--AAGGATCTAGAA--CCAGAAATACC- -ATTT---GA--CCCAGCGATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAT------------TATAAATCA----T------- --------------TCTACTAT--AAAGACACATGC---------ACATG----TATGTT TATT--GCAGCACTATTCACAA-TAGCAAAGACTT--G--GA--ACCA--ACCCAA---A TGTCCATCA---ATGATAG-----ACTGGATAAAG--AAAA----TG------------- -----TGGCA-------------------------------------------------- ------------------------CATAT----ACTCCATGGAATAC-----T--ATGCA GCCATAC----AA----------------------AAGGATAAGTTCATGTTCTTT---- ------------------------------------------------------------ --------GCAGGGACATGGATGAAA-C---TGGAAACCATCATTCTCAGCAA------- ------------------------------------------------ACTAACACAAGA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------GCAAACAC-CA-------- ---CAT---GTTCTCACTCAT----------AAGTGGGAGTGTAAGAAAGAGGGAAGAAA ATATACATAATTTATATATATTCAGCGGATATATACATGTACTTACATATGCATGTGTAT ATGTGTGTGTGTTTGCATAAAAAAATACAGGAAGGATAAACCAGAAACTAATGAAAATGG TTACCTATTTTATACATAGGAGGTGTGTGGGAACAGGATGGAAGGATAAAGATTGGAAGT GAACTTTCTTTGAGAGTTTTGACTTTGGAATCATGTAAATATTTTACATATATTCTATTA AAATAAAATTAAATTTAAATAACAATAAAGAATACAAAGCAAACCCTGAAATTG------ ------------GAAAAGAAATTGAAACAAATGAATCTAACTGTATATCAAATTGGTA-- ------------------------------ACATAACCGCACATATATGCAGAAAAAAAT AGTTATTTTAAGTAATTTTTGAACACAGTATTATGACTGTAAATTCCCAGTGGGGTATAG CCTAAGGACAAAA----------------AGAACTGCAAAGAAATCTTAAACTGCCTTCG TAAGTTTTATTGTTGGTAGTAGTATTGGTATTGTAATTCTGAAACTATTTTGTGTATATT ATAGGACTGAATAAATAAGTAATTATATTAATGTTGTTAGGAACCAGGATTTTCAGTGTA GGAGAAAGGAGATGCAAATATAAAATCGAAGAAAATAAG--------GAAGAACCCTGTA ATGTTGAATTTGAATTGGAAATATCAGTATAAACTCATGGAATTTTTTTTCTAAATAAAC AAGTATGAATTTCCTAGCTCTGTCCACTGAAAAGGCCTAGAAGCAATGACAACTCAGTAG CAATGAGCACAC--------------CTAGAACCCAGATTTTGGTCTCTAAATGCCATTC CCCACTAAAAGAAACCAGGGCTCCTTGGAGAAATGGCTGATTCCAGGTCTGGGGCAGG-- -------------------------------------------------GAATGTACAAG GTGAGCCTGGGACATCTTGTTATGCCAGAAAGCAAGGAAGCTCTCAAAGACTAA-TGGGG TCATGTCAAAAGGAGGCAGGAGCCGGCTTGAAGGGGCTCCCACTGGCCAAATATGGGACA ATTTGAGCATCAGAAAGAATAATGATTGCAATGGATTAGAACACATTAAATATATTAAAA TCCACAAGTCCTTTAAAAAATGATAAAATTAAAGTAAAATGAGAAGACTACAAAAATAAT GCCTTTGTCAACTTTGAAGTTTTCAAAGAGACCAACTCATTACTCTGAAAATTGGC---- ---------------------------------AGTTAAAGGGAAATAATTAAGCCTTTC TGTAATATTTTATCTTGCCTTTCTTGTACGATTTGTATTTCGAGATAACAAGATTGATAA AGGAAAGTTTTTCTTTATTG---------------------------------------- -------AAGAATTTCAGCTAATAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ATGTAGAAGGAATGATAGAATTAGAAAATCACCATTTTG CAACCCCTAATGAAATAATGGATTTAGGCAATGATCATCAATGGGTGGTAATACAAAAAA GCTACAGGTGAAAGCTATTGGGGAATGGGATATTCACATGGTCTCATTA----------- ------------------------------------------------------------ -AATAAATTACTTACAGATGACATATTTATCTATAAGTTGAAAGCAGAAAAGGAGCCTTT ACAATAGAGAAATCGGGCAGACACCACCTAAACCAAATCCAAGTGATAAAAGAAAATGAC TGCCTCACTAGTTCTTGCTCCTGAACCTTCGACGCCAGTGTAGGATCATCACTAAAAGTG GAACAAACTGATATTCTTGACCTCCTGATGTGATGCAATGGGAAGTACACAGCACCACCT ATGAAGTATTCTTCTTATAAAACCAAAAATATCTAACCTGAATCTAATCAAGCCTTTAGA TCTATAAGTTACAAGAAATAAGGAAAATCAATGAACTAAGTAAAAGAATAAACAACGCCA CAAAGAAACAATCAGCCAAATTCAGAATGTGGGACATTCTACAGGACAATTGCCCTAGCT TTTTTATTATTCACCATTTACAAGTTAATGGCAAGAAAGAAAACACACAATAAAAACGAA AGATGGGAGGGACTGTTCTAGATTAAAAAAAATTAAAAAGAATTAAAAACTAACAATGAA GTGCAATGAGTGAACCTTGTTTGGATCCTGAATCAAACAAATAAACAACCATATACAAAT GTTATAAAGGACATTATTAAGATAATTGGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAATTTGAATATGGACTGGTTATTAGATGATATTAA--- ------------------------------------------------------------ ------------------------------------------------------------ --------TGTATTAATGTTTACTTCCTTGTGAGTAAGAATCGTATAATTTTTTGGATGT GATAACGGCATTGTGGTTATGTAGAAAAATGTCCTTGTTTTTTGGAGATACATGCTGAAG TATTTAGGGAAGAAGTGTCATGATATCTGAAACTTGTTTTCAAATGGTTCAGCAAGATGA AACAAAGAAAGAAAAAGAGCAAAAGCAAAAATGGCAAAATGTTAACAATTGGTGAATCTG GGTGATGGGTATATGGGTGTTCATTATGTTATTTTTTATATATTTTTTTGTATGTTTGAA AATTTTCATAATAAAAATTTTTAAAAAAAA------------------------------ ------ >L1PA14 ------------------------------------------------------------ ------------------------------------------------------------ ------------GAGGTGGCCAAG-----------------ATGGCCGACTAGAAGCAGC TAGTGTGCG---------------------------TGGCTCTCACAGAG---------- ---------------------------------------AGGAATGGAAGGGGCGA---- -----------GTAAATACAGCACCTTCAACTGAAACATCCAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------GTACTCGCATTGGG------ACTAATCAAGG------------- --------AAACAACTTGACCCACGGAGAATGGA---------G-AAAAGCAAGGCAGGA CGATGGCCCACCTG---------------------------------------------- ----------------------------------------------GGAGCAACATGGAG CCAGGGGAACCTCCCCTGCCCAGGGAAGCGGTGAGTGAATG---TGTGACCCCGGGAACC CACGCTTCTCC-----------------------------------------CATGGATC TTTGCAACCCTCAGGTCAGGAGATCCCCTTGTGAACCCACTCCACCAGGGCCTTCAGTCT GAC------------------------------------------AGACAGAGCTACGTG GAGTCTTGGCAGAGCAGCCACTCAGGCACACGTGGAGACCTGGGAGCCTTAGATACTTGG GC---------------------------------------------------------- ------------------------------------------------------------ -------------------------------TTTCCGGGCTTCCCAGCAAAAGTAGCTGC AACTCTGGCAAAGTGGGAGGTTAGACCCCTGTACATACCCCT-----------AGGAAAG AGGCTGAATCCAGGGGGCTGAGCAGCAACAGTCTGCAGGCCCCACTTCCATGGCACCTCA CAGGATAAGACCCACTGGCTTGGAATTCCAGCCAGCCACTGGTAGCAGCATTGCACCTCC CTGAGACGGAGCTCCCAGGGGGAGGGGTG----------------GGCCGCCATCTTTGC TGTTTGGGCAACTTAGCCATTCCAGCCTTCGGGCT------------------------- ---------------------------------------TTGGAGAGTCCAAGCTGACCA GG-----------------GGTGGAAGGGATCCCCCAGCACAGCACAGCTGCTCTACAAA AATGTGGCCAGACTGCTTCTTTAAGCAGGTCCCCGATCCTGTTCCTCCTCACTGGGTGGG ACCTCCCAACCGGGGCCTCCAGCCACCCCTACTGGTGTTCTCTGGCTGACAGAGATTTG- ------------------------------------------------------------ ------------------------------------------------------------ ---------AAACCTCCCTGGGATGGAGCTCCCAGAGGGAGGGGTGGGCCACCATCTTTG CTGTTTGGGTGACTTAGCTATTCCAG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------CCTTTGGGCT-------TTAGAGTGTCTGAGGCAACCGGG GGCTGAAGTGGA------------------------------------------------ ---------------------CCCCCAGCACAGCA------------------------- ----------------------CAGCTGCTCTATGAAAACGTGGCCAGACTGCTTTTTTA AGTGG-GTCCCCGATCCCATTCCTCCTCACT----------------------------- ------------------------------------------------------------ --------------------------------------------GGGTGGGACCTCCCAA CTG-------GGGTCTCCAGCCACCTCCTACAGGTGCGTTTGGGCCAGCAACAGGTCTGT ACCTCCCTGGGATGGAGCTCCCAGAGGGAGGGGCAGGCTGCCATCTTTGCTGTTTTGCAG CCTTCACTGGTGATACCTCCAGGTACTGGAAAATCTGAGGTGA----------------- ----------------------CTAGGGACTGGAGCAGGCCCCCAGCATACCGCAGCAGC CCTACGGAAAAGTG--------------------------------GCCAGACTGTTACA TGGGTGCCTGTTCCCATATCTCCTCACTGGGCAGGTCCTCCAGGCCTGGGCCTCCAGCCA CCCCCTGCCAGAGCTATTGAGCCAGTAGCAACTCAGCAACTCCCTGGACAGAGCCTCCAG GGGCAACTGAAAGCCTCTCTGCCACTGCCTCTGCAGTGGAACTGCCCTTGCTACCCTCGG ACTAACGAAGGAGCAAAGACCCTAAGTGCCTTATCCACACCTCCAACAAGCTGCAGTTGA CCCAAGGAGAGGAGGCCAGTCCATCT------------------------------CCCA TGGGTCCCACACACCCCCCACTGCTCGTCACCAGACAGGGAACCCCTGGCTTGGGCCCAC AGCACAGACCCTCCATCCTGGGCTGATTGCACTGAGTGATTGCTGACCTGCATCTCTCTG GGGTGGAGCCCCCAGGAGACAAGCAAAAGACCCTTGGCCACAACCACTACTAAGGTCCCT TCCTCTGCTGCCTCCAAGTTGGGGAAGGAACA-------------TAAACACTGAGATTG CCCCAGAGCTGCAGTGGGCAGCCCAGGAGTGCCAAGCCATGATCTACAGCCAGCACTCAA GGGGGAGAGGAACCCACACTTTCAGAGCATTGAGAGGGAACATGGCTGCAACTGTGAGGA AAC-----------ATAGGGGAGCCACACAACTGAGCAAGAGTCTACCAACTGACCAATA AGC-------------------------------------------CTAAGTGCCACCTA CTGGATCACACCCCAAAGCTTCAACACCAAAAA------TACCTCACTAACATACCCCCC TCTGAAACCAGAGACAAGAAGTCAGCTTCAAATAAAGACCCTGCACAAAGCCTCGGCCCA GTGAAAACATCCAGAAAAGAAGTCTATTGACTGTACTCAATCTACACTGCAGTTAAAGGA ACACCCACATGCATGAG-----------------------------------------AA -------------------------------TGAGAAAGAA-----CCAATGCAAGAACT CTG-------------------------------------GTAACTCAA--------ATG GCCA----GAGTGTCA-------------TATG--TCCT--CCAA---A-TG-------- -------ACT----ACACCAGTTC-------------------TC-CAA---CAAGAGTT CTTAACC----------------AGG---CTGAACTGGCTGGAATGACAGAAAT------ ------AGAA------------TTCAGAATATGGAT-AGGAACAAAGATCATTAAGAT-- --TCAGGAGGATGGC--------------------------AAAACCCAATCC-----AA GGAAAAT---------------------------------------------AAGAATCA C-AATAAAG--------------------------------------------------- -TGATACA----------GGAGCTGAAGGACAAA-------------------------- -------------------------------------------ATAGCCAGTATAAAAAA ----------GAAC---------------CTAATGG------GTC---------TGACA- GAGC----TGAAT---------AACAC---AATACAAGAATTTCACAATGCAATCACA-- ---AGTATTAACAGCAGA----------------ATAA--------------------AC C--AAGC------------------TGAGGAAAG-AAT-CTCAG--AACTTGAAGAC--- -TGGTTCTCTGAAA-T-----AAGACAGTCAG---------ACAAAAATAAA---GAAAA AAGA---ATAAAAAGG-AA---------TGA---ACAAAACCTCC--AAGAAGTATGGG- ATTAT--------G---TAAAGAG--GCCAAATCTACAA--A-TCATTGG--CATC---- ----------CCTGAAAGGGAGGGGGAGAAAGCA---AACAACTTGG---------AAAA CATATTT---CA-----GGATATCATCCAT--GAAAACTTCCCCAACCT----------- ---------TGCTAGAGAGGC--CAAC--AGTCAAATTC-----AGGAAATACAGAGA-A CTCCTGCAA------------GATTCTA-CAC--------------AAGAAGATCATCCC C-------A---------------------AGACACATAATCATCAGATT------TTC- CAAGGTCAAAA---TGAAAG--AAAGAATGT----------------------------- -------------TAAAGGC--AGCTAGAGA---GAAAGGGCAGGT-------------- -----------CAC---CTACAAAGG-GAACCCCA--------------TCAGGCT--AA CAGTGGACCTC-----TCAGCTGAA--ACCCTA-CAAGC------CAG-AAGAGATTG-- -----------GGG-GCCTATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------AAATCT--TCA--ACCAAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCCT-AAGTGA-------AG-------- ------------------------G-AGAAATAAGATCCTTTTCAGATAAGC-AAATGTT GAGGGA-ATTTATTACCACCAGAC---CTGCCTTAC-AAGAG------------------ --------------------ATCTTGAAAGG----------------------------- -----------------------------------AGCAC--------------TAAATA TAG----------------------------------------------------AAAGG AAAG---------------ACCACTA---------------------------------- -------------------------------CCAGCTAATACA----------------- ------------------------------------AAAACAC----------------- ----------TTAAACACACA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCAGTGTCAC-------------------------TATAA A-------------------------------------------------GCAACCACAC ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAACAAGCCAACA--------------TA---ATAACCA GCTAA------------------------------------------------------- ------------------------------------------------------------ -------------CAACACAATGACA---------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------CCACACATA--TCAATACTAAC-CTTGAAT-------G-T AAAT--GGGCT--AAATGC---CCCACTT----------------AAAAGGC------AC AGAG--TGGCAA----GCTG---------GAT-------AAAA---AAGCAAGACCCAA- ---TGG-------TAT-GCTGTCTT-CAAGAGACCCATCT-CACAC--GTAATGACACTC A-TAGGCTCAAAATAAAGGGA---T------------GGAGG----A-AAATCTACCAAG C--------------AAATGG------AAAAC---------------------AGAAA-A AAGCAG--GGGT----TGCAATCCTAATTTC-AGACAAAACAGATTTCAAA-CC------ ----AACAAAGA---TCAAAAAAGAC-AAAG-AAGGGCAT------TACAT------AAT GGTAAA---GGGTTCAATT------CAACAA---GAAG--------AC-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAACACAGGAGCAC CCAG--ATT-CATAAAGCAAGTTCTTAGAGACCT--AC----AAAGAGA---------CA TAGACTCCCAC------ACAATAATAGTGGGAGACTTCAACA----------------CT CCACT------GACAGT-ATTAGACAGATCAT---------------------CGAGGC- -----AGAA-------------AATTAACAAAGATATTCAGGACCTGAAC-TCAACATTG GA------CCAAATGG---ATCTGATAGACCTTTACA--GA----ACTCTCCACCCCAAA AC---AACAGAATATACAT------TCTTCTCATCGC-----CA--CAT-GGCACATACT --C----TAAAATCGACCACATAATTGGACATAAAACAAT-------------------- -CCTCAACAAATGTAAAAGAA--CCGAAAT----------------CATACCAA------ -ACACACTCTCA---GACCACAGTACAA-TAAAAATAGAAGTCAAG-------------- ----------------------------------------------ACTA--------TG --------------AAA-ATTGCTCA---AAACCATGCAA----TTACATGGAAA--T-T AAACAACATG-CTCCTGAA---TG-ACTTTTG--GGTAAATAATGA--AAT--T-AAGGC AGAAATC---------------AAGAAGTTCTTT---GAAAA------------------ ------TAATGAGAACAA-AGA------------TACAAC--ATACCAGAATCTC-TGG- GA-----CACAGCTAAGGCAGTG-----------------------------TTAAGAGG GAAA--TTCATAGCACTA----AATGC----CCACATCAAAAAGT---TAGAAAGATCT- --CAAATTAAC-AACCTAA-CTTCACAACTG---AAAGAAT--TAGAGAAGC------AA GA-----ACAAATCAACC-------------CCAAAGC--TAGCAGAA-GACAAGAAATA ACA---AAAATCAGA-------------------GCTGAACTG---AA-G-GAAATTGAG ACACA------AA------------------------------------AAA-CCA---T TCAAAAGATC-A---------ATG----AATCCA-GGAGTTG------GTTTTTTGAAAA AATTAA------------------------------------------------------ --------------------------------TAA-----AATAGATAGGCCA---CTAG CTA------GACTAA--TAA------------AGAAG------------------AAAAG A---GAGA-AGATCC-----------------AAATAAA--------CACAA-----TT- ---------AGA-AATGATA--AA----------GGGAA---TGTTACTACTGACCCC-A CA-GAAATA--AAAACAAC-CATCAG---------AAACTACT--ATGAA---------- -----------CAC---CTCTATGCACACAA---ACTAGAAAACCTAG---AAGAGAT-- GGATAAATTCCT----------GGACACA---------TAC-----ACCCTCCCA----- -AGACTGAGCCA---GGAAGAAATTGATTCCCTGAAC----------------------- AGACC------------AA-TAATGAGCTCCAAAATTGAAT-C---------AGTAAT-- -AAATAGCCTACC------AACCAAAAAAAG---CCCAGGACC--TGATGG--------- ------------ATTCACA-GCCA--AA-------------------TTCTA-------- ----CCAGATGTAC---AAAGAA-GAGCTGG--TA-CCATTC----------CTACAGAA ACTATT----CC---AAAAAATTGAG------GAGGAG-GG-----------ACTCCTCC CCAACTCATTCT-----ATGAGGCC-----AGCAT---CATCTTG-ATAC---------- ----------------------------------------C--AAAAC-------CTGGC AGA---------------------GAC---ACAACAAAAAA---AGAAAACTTC------ -------------A-GGCCAATAT---CCT----TGATGAACATTGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT TGC-AAACCA------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTAATCCA--CCATGAT------------C AAG---TAGGC-TT----------CATCCCT------------GG--GATGCAAGGTTGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--TGTG ---ATTCATCACAT------AAACAG----AACTAAAGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCTTTTGATAA---AATTCAACACCCCTT- ---------------CATGT---------T---A--AA-----AACTCTCAAT---AAAC TAGGTATTGAAGGAACAT-----ACCTCAAAATAATAAG--------------------- ------AGCCATCTAT-GACAAA--------CCCACAGC-----------CAACAT--TA TACTGAATGGGCA-----AAA-GCTGGAAGC----ATTC---CCC----TT--GAAAACC GGCACA----AGACAAGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTCTATTC---AACATAGT ATT---GGAAGTCCTAGCCAGAGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAGGGCATCCAAATAGGA---AGAGAG------GAAGTCAAA--C--------- ------TATCTCTG-TT--T---GCAGA------TGACAT------GATTCTATATCTA- -GAAAACC--CCATAGT---CTCAGCCC---------A---------------AA--AGC TCCTTCAGCT---------GA--TAAACAACTTCAGCAAAG--TTG-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- ACAAAAAT----CACT-------------------------------------------- -----AGCATTCC--TA-TACACCAAC---------------AACAGCCAAA-----CTG A------------------GAGCCAAATC-AGA----AAGGCAATCCCATTCACAATTGC CACA------------------AAAAGAATA---------AAA------TACCTAGGAAT ACAGCT--------AA--C-CAGGGAGGTG---A---AAGATCTCT---ACAA-TGAGAA TTACAAAACAC------TGCTC-AAAGAAATCA-GA------------GAAG-------- ------------ACAC--AAAC--AAA---TGGA---AA--AACAT---------CCCA- --TGCTC------ATG-GATAGGAAGAATC-A---A---TATC--------------A-- TTAAAATG-----------------------------------------GCTAT--ACTG CCC-AA--AGCAATTTACA-------------------GA---TTCAATGCT---ATT-- ------C-CTATCAAACT--A---------------------CCAATG-AC---ATTCTT ------------------------------------------CACAGAACTAG------- ----------------------AAAAAACTAT------TTTAAAA---TTTATATGGAAC C-------AAAAAAGAGCCC---AA--ATAGCCAAGGCAATCCTAAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACG---TTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---AAAAACAGGCA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAGCCC------AG---AAATAAGG-- -CCAC----------------ACA-------TCTACGA----CCATCT--GATCTTT--- GACAAA--GCTGACAAAAACAAGC--A-------------------ATGGG--GA---AA AG------------ACTCCCTATT--CAATAAATGG---------------TGCTG---- ------G-GATAAC--TGG-CTAGCCA---------------TATGC-AGAAGA---TTG ---------AAGCTGGACCCC---TTCCT-----------TACACC--ATA--T---ACA AAAA-TCAACT-CAAGATGG---AT---TAAAGAC---TTAAATGTA--AAACCCAAAAC TAT------------------------AAAAACCCTGGAA---------------GACAA ---CCTA-------------------------GGCAATACCATCCTGGACATAG--GAA- -----CGGGCAAAGATT-----TCATGACAAA-GACACCA---AAAGCAATCACAAC--- --AAAAGCA---AA----AAT---TGACAAG-TGGGAT----------CTAATT-AA--- ACTTAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAT-------------CAACAGAGTAAACAG------------------- ------A-------------CAACCT------ACAGAA--T-GGGAG---AAAATATTT- --GCAAACTATGCAT--------CT-------GACAAAGGTC--------TA--ATATC- ---CAGCATCTATAAG-GA--ACTTAA---ACA------AA--TTTAC------------ ---AAG--------------AGAAAAACA---AAC--AACCCCA-TTAA---AAAGTGGG C--AAA---------GGA--CATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATAC---AT-GTGGCCAAC--AAGCATATGAAAA AAA----------GCTCAATATCACTG-ATCATTA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACACCAGTCAGAATGGCTATTAT---T A--AAAAG-------TCAAAAA-----ATAACA-GATG--C------------------- ------TGGC-AAGGTTGCA----------GAGAA------------------------- ------------AAGGGAACACTTAT-ACACTGTTGG--TGGG----------------- ----------AGTGT--A-------------AATT---AGTTC----AACCATTGTGG-- ------AAAGCAGTA--TGGCG--A-TTCCTC--AAAGAGCTAAAA--GCAGAACTACC- -ATTT---GA--CCCAGCAATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAGAGGAA------------TATAAATCA----T------- --------------TCTACCAT--AAAGACACATGC---------ACGCA----AATGTT CATT--GCAGCACTATTCACAA-TAGCAAAGACAT--G--GA--ATCA--ACCTAA---A TGCCCATCA---ATGACAG-----ATTGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AAGAATGAGATCATGTCTTTT---- ------------------------------------------------------------ --------GCGGGAACATGGATGGAG-C---TGGAGGCTATTATCCTTAGCAA------- ------------------------------------------------ACTAATGCAGGA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAATAC-CA-------- ---CAT---GTTCTCACTTAT----------AAGTGGGAGCCT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAATG-------ATGAGAA---------------CTT--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------AACACAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------AGGAAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AACAGAC-----------------------------------------------A CTG-------GGGTCTACTT----------------GAGGGTGGAGGGTGGGAGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GAGGAGCAGAAAAGAT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AACTATTGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----CTGGGCTTAATACCTGGGTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ATGAAATAATCTGTACAACAAACCCCCGTGAC------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACGAGTTTACCTATGT------------------------------------------- --------------------------------------------AACAAA---------- -------------------CCTTCACATGTACCCCC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAACCTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------ATAAAAGTTAAAAAA----------------------------------- ------ >L1PA12 ------------------------------------------------------------ ------------------------------------------------------------ --------------GGGGGCCAAG-----------------ATGGCTGACTAGAAGCAGC TATGGTGTG---------------------------TGGCTCTCACGGAG---------- ---------------------------------------AGGAATGAAAGGGGTGA---- -----------GTAAATACAGCACCTTCAACTGAAACATCCAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------GTACTCGCATTGGG------ACTGATCAGGG------------- --------AAACAGCTTGACCCACGGAGAATGGA---------G-AAAAGCAGGGCAGGG CAATGGCCCACCTG---------------------------------------------- ------------------------------------------GGAGTAACATGGAGCCAA GGGAACCCCCATCCCCAGCCCAGGGAAGCGGTGAGTGAATG---TGTGACCCTGGGAAAC CACGCTTCTCC-----------------------------------------CATGGATC TTTGCAACCCTTGGATCAGGAGATCCCCTTGTGAACCCACTCCACCAGGGCCTTCGGTCT GAC------------------------------------------ACACAGAGCTGTGTG GAGTCTCGGCAGAGCAGCTGCTCAGGCATGCACAGAGACCCAGGAGCTTTACATACTCGG GC---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------TCTGGGATCCCCGGCAAAGGTGACTGC AACTCAGGCAAGGCGGGAGGTTGGACCTCCGTACATACCCCT-----------AGGAAGG GGGCTGAATCCAGGGGGCTGAGCAGTGTCAGTCTGTGGGCCCCACTTCCATGGCACCTCA CAGGATAAGACCCACTGGCTTGGAATTCCAGCCAGCCACCGGCAACAGTGTTGTACCTAC CTGGGAATGGGACGGAGCTCCTGGGGGGAGGGGCG----------GGCTGCCATCTTTGC TGTTTGGATAACTCAGCCATTCCAGCCTGTGGGCTTTGGAGAGTCCAAACCAACTGGGGA TGGAAGGGATCCCCC------------AGC---------ACAGCACAGCTGCTCTACCAA AATGTGGCCAGACTGCTTCTTTAAGCAGGACCCTAAATCCATTTCTCCTCACTGGGCGGG ACCTCCCAACTGGGGCCTCCAGCCACCCCGCCGATATCCTCCGGCTGGCAGAGTTTTGAT TTCTCCCTGGGATGGAGTGCCTGGGGGGAGGGGCGGGCCACCATCTTTGCTGTTTGGACA ACTTAGCCATTCCAGCCTGTGGGCTTTGGAGAGTCCAAACCGACTGGGGCAGAAGTGGTC CCCCAGCACAGCACAGCTGCTCTACCAAAGCATGGCCAGACTGCTTCTTTAAGTGGTCCC TGAACCATTCCTCCTCACTGGGTGGGACTTCCCAACCGGGGCCTCCAGCCACTCCCGCCA ATGTTCTCTGGCTGACAGAGATTTGAAATCTCCCTGGGACAGAGCTCCTAGAGGGAGGGG TGGGCTGCCATCTTTGCTGTTTGGGCAACTTAGCTGTTCCAG------------------ ------------------------------------------------------------ --------------------CCTTCAGGCT-------TTGGAGAGCCCAAGCTGACCAGG GGCAGAAGCGG------------------------------------------------- --------------------TACCCCAGCACAGCA------------------------- ----------------------CAGCTGCTCTACGAAAATGTGGCCAGACTGCTTCTTTA AGTGG-GTCCCTGATCCCATTCCTCCTGACT----------------------------- ------------------------------------------------------------ --------------------------------------------GGGTGGGACCTCCCAA CTG-------GGGTCTCCAGCCACCTCCTACAGGTGCGTTTGGGCCGGCAACAGGTCTGT ACCCCCCTGGGACGGAGCTCCCAGAGGAAGGGGCAGGCTGCCATCTTTGCTGTTTCACAG CCTTCACTGGTGATACCTCCAGGTACTGGAAAATCTAAGGTGA----------------- ----------------------CTAGGGTCTGGAGTGGACCCCCAGCAAACTGCAGCAGC CCTATAGAAAAGTG--------------------------------GCCAGACTGTTAAA TGGGTGCCCATTCCCATATCTCCTCACTGGGCAGGTCCTCCAGGCCTGGGCCTCCAGCCA CCCCCCGCCAGAGCTATCGAGCCAGTAGCAGCTCTGCAACTCCCTGGACAGAGCCCCCAG GGGCAACTGAAAGCCTCTCTGCCACTGCCTCTGCAGTGGAACTGCCCTTGCTACCCTCAG ATTAATAGAGGAGCAAAGACCCTAAGTGCCTTATCCACACCTCCAACAAGCTGCAGTTGA CCCAAGGAGAGGAGGCCAGTCTGTCT------------------------------CCCA TGGGTCCCACCCACCCCCCACTGCTCATCACCAGACAGGGAACCCCTGGCTTGGGCCCAC AGCACAGACCCTCCATCCTGGGCTGATTGCACTGAGCGATTGCTGACCTGCATCTCTCTG GGGTGGAGCCCCCCGGAGAAAGGCAAAAGCCACTTGGCCACAACCACTACTAAGGTCCCT TCCTCTTCTGCCTCCAATATGGTGAAGAAAAA-----------TAAACAAACAAAGATCA CCCCAGAGCTGCAGTGGGCAGCCCAGGAGTGCCAAGCCATGATCTACAGCCAGCACTCAA GGGGGAGAGGAACCCACACTTTCAGAGCATTGAAAGTGAACACAGCTGCAACTACAAGGA AAC-----------ACACGGGAGCCACACAACCGAGCAAGAGTCTACCAACTGACCAACA -----CACAAAAACCCCAT---------------------------CCAAAGGTCAGC-- ---------------------------------------AACCTCAAAGAT--------- ---------TGAAG---------------------------------------------- -GTAGATAA------GCCCAC-------AAAG---------------------------- ------------------------------------------------------------ -------------------------------TGAGAAAGAA-----CCAATGTAAGAACT CCG-------------------------------------GTAACTCAA--------ATG GCCA----GAGTGTCA-------------TATG--TCCT--CCAA---A-TG-------- -------ACC----GCACCAGTTC-------------------TC-CAA---CAAGAGTT CTTAACC----------------AGG---CTGAACTGGCTGGAATGACAGAAAT------ ------AGAA------------TTCAGAATATGGAT-AGAAACAAAGATCATTGAGAT-- --TCAGGAGGACGGC--------------------------AAAACCCAATCC-----AA GGAAAAT---------------------------------------------AAGAATCA C-AATAAAG--------------------------------------------------- -TGATACA----------GGAGCTGAAGGACAAA-------------------------- -------------------------------------------ATAGCCAGTATAAAAAA ----------GAAC---------------CTAATGG------GTC---------TGACA- GAGC----TGAAT---------AACAC---AATACAAGAATTTCACAATGCAATCACA-- ---AGTATTAACAGCAGA----------------ATAA--------------------AC C--AAGC------------------TGAGGAAAG-AAT-CTCAG--AACTTGAAGAC--- -TGGTTCTCTGAAA-T-----AAGACAGTCAG---------ACAAAAATAAA---GAAAA AAGA---ATAAAAAGA-AA---------TGA---ACAAAACCTCC--AAGAAGTATGGG- ATTAT--------G---TAAAGAG--GCCAAATCTACAA--A-TCATTGG--CATC---- ----------CCTGAAAGGGAGGGGGAGAAAGCA---AACAACTTGG---------AAAA CATATTT---CA-----GGATATCATCCAT--GAAAACTTCCCCAACCT----------- ---------TGCTAGAGAGGC--CAAC--AGTCAAATTC-----AGAAAATACAGAGA-A CTCCTGCAA------------GATTCTA-CAC--------------AAGAAGATCATCCC C-------A---------------------AGACACATAATCATCAGATT------TTC- CAAGGTCAAAA---TGAAAG--AAAGAATGT----------------------------- -------------TAAAGGC--AGCCAGAGA---GAAAGGGCAGGT-------------- -----------CAC---CTACAAAGG-GAACCCCA--------------TCAGGCT--AA CAGCAGACCTC-----TCAGCTGAA--ACCCTA-CAAGC------CAG-AAGAGATTG-- -----------GGG-GCCTATA-T-------TCAACT--TTCT-------------AAAG AAAAA---------------AAAACT--TCA--ACCAAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCCT-AAGTGA-------AG-------- ------------------------G-AGAAATAAGATCCTTTTCAGATAAGC-AAATGTT GAGGGA-CTTCATTACCACCAGAC---CTGCCTTAC-AAGAA------------------ --------------------ATCTTGAAAGA----------------------------- -----------------------------------AGCA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ACAC----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------A------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCAGTGACAC-------------------------TATAA A-------------------------------------------------GCAACCACAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAACAAGTCTGCA--------------AA---ATAACCA GCTAG------------------------------------------------------- ------------------------------------------------------------ -------------CATC------ATG---------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------CCACACATA--ACAATACTAAC-CTTAAAT-------G-T AAAT--GGGCT--AAATGC---CCCAATT----------------AAAAGAC------AC AGAG--TGGCAA----GCTG---------GAT-------AAAG---AACCAAGACCCAT- ---TGG-------TAT-GCTGTCTT-CAAGAGACCCATCT-CACAT--GCAAAGACACAC A-TAGGCTCAAAATAAAGGGA---T------------GGAGG----A-AAATTTACCAAG C--------------AAATGG------AAAAC---------------------AGAAA-A AAGCAA--GGGT----TGCAATCCTAGTTTC-TAACAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAAAGAC-AAAG-AAGGGCAT------TACAT------AAT GGTAAA---GGGTTCAATT------CAACAA---GAAG--------AG-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAACACAGGAGCAC CCAG--ATT-CATAAAGCAAGTTCTTAGAGACCT--TC----AAAGAGA---------CT TAGACTCCCAC------ACAATAATAGTGGGAGACTTTAACA----------------CC CCACT------GACAAT-ATTAGACAGATCAT---------------------TGAGAC- -----AGAA-------------AATTAACAAAGATATTCAGGACCTGAAC-TCAGCTCTG GA------TCAAATGG---ACCTGATAGATATCTACA--GA----ACTCTCCACCCAAAA AC---AACAGAATATACAT------TCTTCTCATTGC-----CA--CAT-GGCACTTACT --C----TAAAATTGATCACATAATCGGAAGTAAAACACT-------------------- -CCTCAGCAAATGCAAAAGAA--CTGAAAT----------------CATAACAA------ -ACAGTCTCTCA---GACCACAGCACAA-TCAAATTAGAACTCAAG-------------- ----------------------------------------------ACTA--------AG --------------AAA-TTCACTCA---AAACCATACAA----TTACATGGAAA--T-T GAATAACCTG-CTCCTGAA---TG-ACTTTTG--GGTAAATAATGA--AAT--T-AAGGC AGAAATC---------------AAGAAGTTCTTT---GAAAC------------------ ------TAATGAGAACAA-AGA------------TACAAC--ATACCAGAATCTC-TGG- GA-----CACAGCTAAGGCAGTG-----------------------------TTAAGAGG GAAA--TTTATAGCACTA----AATGC----CCACATCAAAAAGC---TAGAAAGATCT- --CAAGTTAAC-AACCTAA-CATCACAACTA---AAAGAAC--TAGAGAACC------AA GA-----GCAAACAAATC-------------CCAAAGC--TAGCAGAA-GACAAGAAATA ACC---AAAATCAGA-------------------GCTGAACTG---AA-G-GAGATAGAG ACACA------AA------------------------------------AAA-CCA---T TCAAAAGATC-A---------ACA----AATCCA-GGAGCTG------GTTTTTTGAAAA AAATAA------------------------------------------------------ --------------------------------TAA-----AATAGATAGACCA---CTAG CTA------GACTAA--TAA------------AGAAG------------------AAAAG A---GAGA-AGATTC-----------------AAATAAA--------CACAA-----TC- ---------AGA-AATGATA--AG----------GGGGA---TATTACCACTGACCCC-A CA-GAAATA--CAAACAAC-CATCAG---------AGAATATT--ATAAA---------- -----------CAC---CTCTATGCACATAA---ACTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----ACCCTCCCA----- -AGACTGAACCA---GGAAGAAATTGAATCCCTGAAC----------------------- AGACC------------AA-TAACGAGTTCTGAAATTGAGG-C---------AGTAAT-- -AAATAGCCTACC------AACCAAAAAAAG---CCCAGGACC--AGACGG--------- ------------ATTCACA-GCTG--AA-------------------TTCTA-------- ----CCAGATGTAC---AAAGAA-GAGCTGG--TA-CCATTC----------CTACTGAA ACTATT----CC---AAAAAATTGAA------AAGGAG-GG-----------ACTCCTCC CTAACTCATTCT-----ATGAGGCC-----AGCAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CTGGC AGA---------------------GAT---ACAACAAAAAA---AGAAAACTTC------ -------------A-GGCCAATAT---CCT----TGATGAACATTGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT GGC-AAACCA------------------AA--TC--------------CA--GGA----- --------GCAAAAT---------AAAAAGCTTTTCTA--CCATGAA------------C AAG---TAGGCTTT----------CATCCCC------------AG--GATGCAAGGTTGG -T----------------------TA-AAC-----ATATGC--AAATAAATAAA--TGTG AT-ATTCATCACAT------AAACAG----AACTAAAGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCTTTCGATAA---AATTCAACATCCCTT- ---------------CATGT---------T---A--AA-----AACTCTCAAT---AAAC TAGGTATTGAAGGAACAT-----ACCTCAAAATAATAAG--------------------- ------AGCCATATAT-GACAAA--------CCCACAGC-----------CAACAT--CA TACTGAATGGGCA-----AAA-GCTGGAAGC----ATTC---CCC----TT--GAAAACC GGCACA----AGACAAGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ATT---GGAAGTTCTGGCCAGAGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAGGACATTCAAATAGGA---AGAGAG------GAAGTCAAA--C--------- ------TATCTCTG-TT--T---GCAGA------TGACAT------GATCCTATATCTA- -GAAAACC--CCATCGT---CTCAGCCC---------A---------------AA--AGC TTCTTAAGCT---------GA--TAAACAACTTCAGCAAAG--TCT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- GCAAAAAT----TACT-------------------------------------------- -----AGCATTCC--TA-TACACCAAC---------------AACAGTCAAG-----CCG A------------------GAGCCAAATC-ATG----AATGAACTCCCATTCACAATTGC CACA------------------AAAAGAATA---------AAA------TACCTAGGAAT AAAACT--------AA--C-AAGGGAAGTT---G---AAAAGCTCTTCAAAAA-GAAGAA CTACAAACCAC------TGCTC-AAAGAAATCA-GA------------GATG-------- ------------ACAC--AAAC--AAA---TGGA---AA--AACAT---------TCCA- --TGCTC------ATG-GATAGGAAGAATC-A---A---TATC--------------A-- TTAAAATG-----------------------------------------GCCAT--ATTG CCC-AA--AGCAATTTATA-------------------GA---TTCAATGCT---ATT-- ------C-CCATTAAACT--A---------------------CCACTG-AC---ATTCTT ------------------------------------------CACAGGACTAG------- ----------------------AAAAAACTAT------TTTAAAA---TTCATATGGAAC C-------AAAAAAGA---C---AA--ATAGCCAAGGCAATCCTCAGC------AA--GA ACA---AAGC--T-------GGA--GGCATCATG---CTACCTAACTTCAAACT-----A TACTAC-------------------------AG---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--T-----------------AAAAACAGATA--- ---CATAGACATAA---ATGG-AAGAAAAAAGAGACCAG------AG---AAATAAGA-- -CCAC----------------ACA-------CCTACAA----CTATCT--GATCTTT--- GACAAA--CCTGACAAAAACAAGC--A-------------------ATGGG--GA---AA GG------------ATTCCCTATT--CAATAAATGG---------------TGCTG---- ------G-GATAAC--TGG-CTAGCCA---------------TATGC-AGAAAA---TTG ---------AAACTGGACCC------CCT-----------TATAAC--ACA--A---ACA AAAA-TTAACT-CAAGATGG---AT---TAAAGAC---TTAAATGTA--AAACCTAAAAC CAT------------------------AAAAACCCTAGAA---------------GAACA ---CCTA-------------------------GGCAATACCCTTCAGGACATAG--GCA- -----TGGGCAAAGATT-----TCATGAAAAA-AACACCA---AAAGCAATTGCAAC--- --AAAAGCA---AA----AAT---TGACAAA-GGGG-------------TTATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAT-------------CAACAGAGTAAACAG------------------- ------A-------------CAACCT------ACAGAA--T-GGGAG---AAAATTTTT- --GCAAACTATGCAT--------CT-------GACAAAGGTC--------TA--ATATC- ---CAGCATCTATAAG-GA--ACTTAA---ACA------AA--TTTAC------------ ---AAG--------------AAAAAAACA---AAC--AACCCCA-TTAA---AAAGTGGG C--AAA---------GGA--CATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATAC---AC-GTGGCCAAC--AAACATATGAAAA AAA----------GCTCAACATCACTG-ATCATTA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACACCAGTCAGAATGGCTATTAT---T A--AAAAG-------TCAAAAA-----ACATCA-GATG--C------------------- ------TGGA-CAGGTTGTG----------GGGAA------------------------- ------------AATGGAAAGCTTAA-ACACTGTTGG--TGGG----------------- ----------AGTTT--AAAGTGGTTGTACCAATT---AGTTC----AACCATTGTGG-- ------AAGACAGTG--TGGTGATA-TTTCTA--AGAGATCTAAAA--ACAGAAATACC- -ATTT---GA--CCCAGCAATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAA------------TATAAATTA----T------- --------------TCTATTAT--AAAGACACATGC---------ACGCA----TATGTT CATT--GCAGCACTATTCACAA-TAGCAAAGACAT--G--GA--ATCA--ACCCAA---A TGCCCATCA---ATGATAG-----ACTGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AAGAATGAGATCATGTCCTTT---- ------------------------------------------------------------ --------GCAGGGACATGGATGGAG-C---TGGAGGCCATTATCCTTAGCAA------- ------------------------------------------------ACTAACACAGGA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAATAC-CG-------- ---CAT---GTTCTCACTTAT----------AAGTGGGAGCCT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAATG-------ATGAGAA---------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAT----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GGGGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AACACAC-----------------------------------------------A CTG-------GGGCCTATCG----------------GAGGGTGGAGGGTGGGAGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GAGGATCAGGAAAAAT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AACTAATGGATA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----CTAGGCTTAATACCTGGGTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ATGAAATAATCTGTACAACAAACCCCCATGAC------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACACGTTTACCTATGT------------------------------------------- --------------------------------------------AACAAA---------- -------------------CCTGCACATCCTGCACATGTACCCCT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAACTTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------ATAAAAGTTA---------------------------------------- ------ >L1PA7 ------------------------------------------------------------ ------------------------------------------------------------ -----------GGTGGCTGGCAAG-----------------ATGGCCGAATAGGAACAGC TCCGGTCTG---------------------------CAGCTCCCAGCGAG---------- ---------------------------------------ATCAACGCAGAAGGCGG---- -----------GTGATTTCTGCATTTCCAACTGAGGTACCCGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------CTCATCTCATTGGG------ACTGGTTAGAC------------- --------AGTGGGTGCAGCCCACGGAGGGCGAG---------C-CGAAGCAGGGTGGGG CGTCGCCTCACCCG----------GGAAGCG----------------------------- --------------------------------------------------CAAGGGGTCG GGGAACTCCCTCCCCTAGCCAAGGGAAGCCGTGA-----GG---GACTGTGCCGTGAGGA ACGGTGCATTCCGGCCCAGATACTACGCTTTTC-------------------CCACGGTC TTCGCAACCCGCAGACCAGGAGATTCCCTCGGGTGCCTACACCACCAGGGCCCTGGGTTT CAAGCACAAAACTGGGCGGCCGTTTGGGCAGACACCGAGCTAGCTGCAGGAGTTTTTTTT CATACCCCAGTGGCGCCTGGAACGCCAGCGAGACAGAACCGTTCACTCCCCTGGAAAGGG GGCTGAAGCCAGGG---------------------------------------------- ------------------------------------------------------------ -------------------------------AGCCAAGTGGTCTAGCTCAGCGGATCCCA CCCCCACGGAGCCCAGCAAGCTAAGATCCACTGGCTTGAAATTCTCGCTGCCAGCACAGC AGTCTGAAGTCGACCT-------------------------------------------- ------------------------------------------------------------ --GGGACGCTCGAGCTTGGTGGGGGGAGGGGC-------------GTCCGCCATTACTGA GGCTTGAGTAGGCGGTTTTCCCCTCACAGTGTAA-------------------------- ---------------------------------------ACAAAGCCGCCGGGAAGTTCG AA-------------------CTGGGCGGAGCCCACCGCAG------------------- ------------------------------------------------------------ ----CTCGGCAAAGCCGCTGTAGCC----------------------------------- ------------------------------------------------------------ ----------------------------------------AGACTGCCTCTCTAGATT-- ---------CCTCCTCTCTGGGCAGG-GCATCTCTGAAAGAAAGGCAGCAGCCCCAGTCA GGGGCTTATAGATAAAACTCCCATCTCCCTGGGACAGAGCACCTGGGGGAAGGGGCGGCT GTGGGCGCAGC------------------------------------------------- ------------------------------------------------------------ --------------------TTCAGCAGAC-------TTAAACGTTCCTGCCTGCCGGCT CTGAAGAGAGCAGCGGA------------------------------------------- --------------------TCTCCCAGCACAGCG------------------------- --------------------------CTCGAGCTCTGCTAAGGGACAGACTGCCTCCTCA AGTGG--------GTCCCTGACCCCCGTGCCTCCTGACT--------------------- ------------------------------------------------------------ --------------------------------------------GGGAGACACCTCCCAG CAG-------GGGTCGACAGACACCTCATACAGGAGAGCTCCGGCTGGCATCTGGCGGGT G----------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------CCCCTCTGGGACGAAG CTTCCAGAGGAAGG--------------------------------AACAGGCAGCAATC TT------------TGCTGTTCTGCAGCCTCCGCTGG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----TGATACCCAGGCAAACAGGGTCTGGAGTGGA----CCTCCAGCAAACTCCAGCAGA CCTGCAGCAGAGGGGCCTGACTGTTA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAAGGAAAA-----------CTAACAAACAGAAAGGA ------------------------------------------------------------ --------------------------ATAGCATCAACATCAACAAAA------------- --A-----------GGACGTCCACACAAAAACCCCAT----------------------- ----------------------------------------------CCGAAGGTCACC-- ---------------------------------------AACATCAAAGAC--------- ---------CAAAG---------------------------------------------- -GTAGATAAATCCACGAAG----------------------------------------- ------------------------------------------------------------ -------------------------------TGAGGAAAAA-----CCAGCGCAAAAAGG CTG-------------------------------------AAAATTCCA--------AAA ACCA----GAACGCCT-------------CTTC--TCCT--CCAA---A-GG-------- -------ATC----ACAACTCCTC-------------------GC-CAG---CAAGGGAA CAAAACT----------GGACGGAGA---ATGAGTTTGACGAATTGACAGAAGT------ ------AGGC------------TTCAGAAGGTGGGT-AATAACAAACTCCTCCGAGCT-- --AAAGGAGCATGTT--------------------------CTAACCCAATGC-----AA GGAAGCT---------------------------------------------AAGAACCT T-GAAAAAA--------------------------------------------------- -GGTTAGA----------GGAATTGCTAACTAGA-------------------------- -------------------------------------------ATAACCAGTTTAGAGAA ----------GAAC---------------ATAAATG------ACC---------TGATG- GAGC----TGAAA---------AACAC---AGCACGAGAACTTCGTGAAGCATACACA-- ---AGTATCAATAGCCGA----------------ATCG--------------------AT C--AAGC------------------GGAAGAAAG-GAT-ATCAG--AGATTGAAGAT--- -CAACTTAATGAAA-T-----AAAGCGTGAAG---------ACAAGATTAGA---GAAAA AAGA---ATGAAAAGG-AA---------CGA---ACAAAGCCTCC--AAGAAATATGGG- ACTAT--------G---TGAAAAG--ACCAAACCTACGT--T-TGATTGG--TGTA---- ----------CCTGAAAGTGACGGGGAGAATGGA---ACCAAGTTGG---------AAAA CACTCTT---CA-----GGATATTATCCAG--GAGAACTTCCCCAACCT----------- ---------AGCAAGACAGGC--CAAC--ATTCAAATTC-----AGGAAATACAGAGA-A CACCACAAA------------GATACTC-CTC--------------GAGAAGAGCAACCC C-------A---------------------AGACACATAATCGTCAGATT------CAC- CAAGGTTGAAA---TGAAGG--AAAAAATGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGTCGGGT-------------- -----------TAC---CCACAAAGG-GAAGCCCA--------------TCAGACT--AA CAGCGGATCTC-----TCTGCAGAA--ACCCTA-CAAGC------CAG-AAGAGAGTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAATTT--TCA--ACCCAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCAT-AAGCGA-------AG-------- ------------------------G-AGAAATAAAATCCTTTACAGACAAGC-AAATGCT GAGAGA-TTTTGTCACCACCAGGC---CTGCCTTAC-AAGAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCAC--------------TAAATA TGG----------------------------------------------------AAAGG AAAA---------------ACCGGTA---------------------------------- -------------------------------CCAGCCACTGCA----------------- ------------------------------------AAAACAT----------------- --------ACCAAATTGGTAAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCATCGACAC-------------------------TATGA A-------------------------------------------------GAAACTGCAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CAACTAACGGGCA--------------AA---ATAACCA GCTAG------------------------------------------------------- ------------------------------------------------------------ -------------CATCATA---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCACACATA--ACAATATTAAC-CTTAAAT-------G-T AAAT--GGGCT--AAATGC---CCCAATT----------------AAAAGAC------AC AGAC--TGGCAA----ATTG---------GAT-------AAAG---AGTCAAGACCCAT- ---CGG-------TGT-GCTGTATT-CAGGAGACCCATCT-CACGT--GCAAAGACACAC A-TAGGCTCAAAATAAAGGGA---T------------GGAGG----A-ATATTTACCAAG C--------------AAATGG------AAAGCAAAAAAAAAAAAAA-------AAAAAAA AAGCAG--GGGT----TGCAATCCTAGTCTC-TGATAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAAAGAC-AAAG-AAGGGCAT------TACAT------AAT GGTAAA---GGGATCAATG------CAACAA---GAAG--------AG-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAATACAGGAGCAC CCAG--ATT-CATAAAGCAAGTTCTTAGAGACCT--AC----AAAGAGA---------CT TAGACTCCCAC------ACAATAATAGTGGGAGACTTTAACA----------------CC CCACT------GTCAAT-ATTAGACAGATCAA---------------------CGAGAC- -----AGAA-------------AATTAACAAGGATATTCAGGACTTGAAC-TCAGCTCTG GA------CCAAGCGG---ACCTAATAGACATCTACA--GA----ACTCTCCACCCCAAA TC---AACAGAATATACAT------TCTTCTCAGCAC-----CA--CAT-CGCACTTATT --C----TAAAATTGACCACATAATTGGAAGTAAAACACT-------------------- -CCTCAGCAAATGCAAAAGAA--CGGAAAT----------------CATAACAA------ -ACAGTCTCTCA---GACCACAGTGCAA-TCAAATTAGAACTCAGG-------------- ----------------------------------------------ATTA--------AG --------------AAA-CTCACTCA---AAACCGCACAA----CTACATGGAAA--C-T GAACAACCTG-CTCCTGAA---TG-ACTACTG--GGTAAATAACGA--AAT--T-AAGGC AGAAATA---------------AATAAGTTCTTT---GAAAC------------------ ------CAATGAGAACAA-AGA------------CACAAC--GTACCAGAATCTC-TGG- GA-----CACAGCTAAAGCAGTG-----------------------------TTTAGAGG GAAA--TTTATAGCACTA----AATGC----CCACAGGAGAAAGC---GGGAAAGATCT- --AAAATCGAC-ACCCTAA-CATCACAATTA---AAAGAAC--TAGAGAAGC------AA GA-----GCAAACAAATT-------------CAAAAGC--TAGCAGAA-GACAAGAAATA ACT---AAGATCAGA-------------------GCAGAACTG---AA-G-GAGATAGAG ACACA------AA------------------------------------AAA-CCCCCTT TAAAAAAATC-A---------ATG----AATCCA-GGAGCTG------GTTTTTTGAAAA GATTAA------------------------------------------------------ --------------------------------CAA-----AATAGATAGACCG---CTAG CCA------GACTAA--TAA------------AGAAG------------------AAAAG A---GAGA-AGAATC-----------------AAATAGA--------CACAA-----TA- ---------AAA-AATGATA--AA----------GGGGA---TATCACCACTGATCCC-A CA-GAAATA--CAAACTAC-CATCAG---------AGAATACT--ATAAA---------- -----------CAC---CTCTATGCAAATAA---ACTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----ACCCTCCCA----- -AGACTAAACCA---GGAAGAAGTCGAATCCCTGAAT----------------------- AGACC------------AA-TAACAAGTTCTGAAATTGAGG-C---------AGTAAT-- -TAATAGCCTACC------AACCAAAAAAAG---CCCAGGACC--AGACGG--------- ------------ATTCACA-GCCG--AA-------------------TTCTA-------- ----CCAGAGGTAC---AAAGAG-GAGCTGG--TA-CCATTC----------CTTCTGAA ACTATT----CC---AAACAATAGAA------AAAGAG-GG-----------ACTCCTCC CTAACTCATTTT-----ATGAGGCC-----AGCAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CTGGC AGA---------------------GAC---ACAACAAAAAA---AGAAAATTTC------ -------------A-GGCCAATAT---CCC----TGATGAACATCGAT------------ ------------GCGAAAATCC-TCA--------------------A----TAAAATACT GGC-AAACCG------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTTATCCA--CCACGAT------------C AAG---TCGGC-TT----------CATCCCT------------GG--GATGCAAGGCTGG -T----------------------TC-AAC-----ATACGC--AAATCAATAAA--CGTA ---ATCCATCACAT------AAACAG----AACCAATGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCCTTCGATAA---AATTCAACACCCCTT- ---------------CATGC---------T---A--AA-----AACTCTCAAT---AAAC TAGGTATTGATGGAACGT-----ATCTCAAAATAATAAG--------------------- ------AGCTATTTAT-GACAAA--------CCCACAGC-----------CAATAT--CA TACTGAATGGGCA-----AAA-GCTGGAAGC----ATTC---CCT----TT--GAAAACC GGCACA----AGACAAGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ATT---GGAAGTTCTGGCCAGGGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAGGGTATTCAAATAGGA---AGAGAG------GAAGTCAAA--T--------- ------TGTCTCTG-TT--T---GCAGA------TGACAT------GATTGTATATTTA- -GAAAACC--CCATCGT---CTCAGCCC---------A---------------AA--ATC TCCTTAAGCT---------GA--TAAGCAACTTCAGCAAAG--TCT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- GCAAAAAT----CACA-------------------------------------------- -----AGCATTCC--TA-TACACCAAT---------------AATAGACAAA-----CAG A------------------GAGCCAAATC-ATG----AGTGAACTCCCATTCACAATTGC TACA------------------AAGAGAATA---------AAA------TACCTAGGAAT ACAACT--------TA--C-AAGGGATGTG---A---AGGACCTCT---TCAA-GGAGAA CTACAAACCAC------TGCTC-AAGGAAATAA-GA------------GAGG-------- ------------ACAC--AAAC--AAA---TGGA---AA--AACAT---------TCCA- --TGCTC------ATG-GATAGGAAGAATC-A---A---TATC--------------G-- TGAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--AGTAATTTATA-------------------GA---TTCAATGCT---ATC-- ------C-CCATCAAGCT--A---------------------CCATTG-AC---TTTCTT ------------------------------------------CACAGAATTAG------- ----------------------AAAAAACTAC------TTTAAAT---TTCATATGGAAC C-------AAAAAAGAGCCC---GT--ATAGCCAAGACAATCCTAAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACG---CTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---CAAAACAGATA--- ---TATAGAC--CA---ATGG-AACAGAACAGAGGCCTC------AG---AAATAACG-- -CCAC----------------ACA-------TCTACAA----CCATCT--GATCTTT--- GACAAA--CCTGACAAAAACAAGC--A-------------------ATGGG--GA---AA GG------------ATTCCCTATT--TAATAAATGG---------------TGTTG---- ------G-GAAAAC--TGG-CTAGCCA---------------TATGC-AGAAAA---CTG ---------AAACTGGACCCC---TTCCT-----------TACACC--TTA--T---ACA AAAA-TTAACT-CAAGATGG---AT---TAAAGAC---TTAAACGTA--AGACCTAAAAC CAT------------------------AAAAACCCTAGAA---------------GAAAA ---CCTA-------------------------GGCAATACCATTCAGGACATAG--GCA- -----TGGGCAAAGACT-----TCATGACTAA-AACACCA---AAAGCAATGGCAAC--- --AAAAGCC---AA----AAT---TGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAT-------------CATCAGAGTGAACAG------------------- ------G-------------CAACCT------ACAGAA--T-GGGAG---AAAATTTTT- --GCAATCTATCCAT--------CT-------GACAAAGGGC--------TA--ATATC- ---CAGAATCTACAAG-GA--ACTTAA---ACA------AA--TTTAC------------ ---AAG--------------AAAAAAACA---AAC--AACCCCA-TCAA---AAAGTGGG C--GAA---------GGA--TATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATTT---AT-GCGGCCAAC--AAACATATGAAAA AAA----------GCTCATCATCACTG-GTCATTA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACGCCAGTTAGAATGGCGATCAT---T A--AAAAG-------TCAGGAA-----ACAACA-GATG--C------------------- ------TGGA-GAGGATGTG----------GAGAA------------------------- ------------ATAGGAACGCTTTT-ACACTGTTGG--TGGG----------------- ----------AGTGT--A-------------AATT---AGTTC----AACCATTGTGG-- ------AAGACAGTG--TGGCG--A-TTCCTC--AAGGATCTAGAA--CCAGAAATACC- -ATTT---GA--CCCAGCAATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAT------------TATAAATCA----T------- --------------TCTACTAT--AAAGACACATGC---------ACACG----TATGTT TATT--GCAGCACTGTTCACAA-TAGCAAAGACTT--G--GA--ACCA--ACCCAA---A TGCCCATCA---ATGATAG-----ACTGGATAAAG--AAAA----TG------------- -----TGGCA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AAGGATGAGTTCATGTCCTTT---- ------------------------------------------------------------ --------GCAGGGACATGGATGAAG-C---TGGAAACCATCATTCTCAGCAA------- ------------------------------------------------ACTAACACAGGA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAACAC-CG-------- ---CAT---GTTCTCACTCAT----------AAGTGGGAGTTT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAACA-------ATGAGAA---------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GGA--------GGGGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----ATCACAC-----------------------------------------------A CCG-------GGGCCTGTCG----------------GGGGGTGGGGGGCTAGGGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TAGCATTAGGAGAAATACCTAATGTAGATG ACG--------------------------------------------------------- ------------------------------------------------------------ ---------------------------------GGTTGATGGGTG--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAGCAAACCACCATGGCA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -CGTGTAT-ACCTATGT------------------------------------------- --------------------------------------------AACAAA---------- -------------------CCTGCACGTTCTGCACATGTATCCCA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAACTTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GTATAATAATAAAAAAAA---------------------------------------- ------ >L1PA8 ------------------------------------------------------------ ------------------------------------------------------------ -----------------TGGCAAG-----------------ATGGCCGAATAGGAACAGC TCCGGTCTG---------------------------CAGCTCCCAGCGAG---------- ---------------------------------------ACCAATGCAGAAGGCGG---- -----------GTGATTTCTGCATTTCCAACTGAGGTACCCAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------TTCATCTCATTGGG------ACTGGTTAGGC------------- --------AGTGGGTGCAGCCCACGGAGGGCGAG---------C-AGAAGCAGGGTGGGG CGTCGCCTCACCCA----------GGAAGTG----------------------------- --------------------------------------------------CAAGGAGCCG GGGGACTCCCTTCCCCAGCCAAGGGAAGCCGTGA-----GG---GACTGTGCT------- --------ATCCGGCCTAGGTACTACGCTTTTC-------------------CCACGGTT TTTGCAATCCGCAGATCAGGAGATTCCCTCGTGTGCCTACACCACCAGGGCCCTGGGTTT ---------------------------------------------CAAGCACAAAACTGG GCGGCTGTTTGGGCAGACACCGAGCTAGCTGGGGGATTTTTTTTTTTTTTTCGTACCCCA GTGGCGCCTGGAACCCCAGCGAGACAGAACCGTTCACT---------------------- --------------------------------------------------CCCCTGGAAA GGGGGCTGAAGCCAGGGAGCCAAGTGGTCTCGCTCAGCGGGTCC--------------CA CTCCCACGGAGCCCAGCAAGCTAAGAACCACTGGCTTGAAATTCTCGCTGCCAGCACAGC AGTCTGAAGTCGACCT-------------------------------------------- ------------------------------------------------------------ --GGGACGATCGAGCTTGGTGGGGGGAGGGGC-------------GTCCGCCATTACTGA GGCTTGAGTAGGCGG--------------------------------------------- -----------TTTT------------CCCCTGACAGTGCTAAGGAGGCTGGGAGGTTTG GA-------------------CTGGGCGGAACTCACCACAG------------------- ------------------------------------------------------------ ----CGTGGCAAAGCGGCTGTGGCC----------------------------------- ------------------------------------------------------------ ----------------------------------------AGACTGCCTCTCTAGATT-- ---------CCTCCTCACTGGGCAGG-GCATCTCTGAAAGAAAGGCAGCAGCCCCAGTCA GGGGCTTATAGATAAAACTCCCATCTCCCTGGGACAGAGCACCTGGGGGAAGGGGCGGCT GTGGGCGCAGC------------------------------------------------- ------------------------------------------------------------ --------------------TTCAGCGGAC-------TTAAACGTTCCTGCCTGCCGGCT CTGAAGAGAGCAGCGGATCCTGACAAGG-------------------------------- ---------------AGGATTCTCCCAGCACAGCG------------------------- --------------------------CTCGAGCTCTGCTAAGGGACAGACTGCCTCCTCA AGTGG-GT-------CCCTGACCCCCGTGCCTCCTGACT--------------------- ------------------------------------------------------------ --------------------------------------------GGGAGAGACCTCCCAA CAG-------GGGTCGACAGACACCTCATACAGGAGAGCTCCGGCTGGCATCAGGCCGGT G----------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------CCCCTCTGGGACGAAG CTTCCAGAGGAAGG--------------------------------AGCAGGCAGCAATC TT------------TGCTGTTCTGCAGCCTCCGCTGG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----TGATACCCAGGCAAACAGGGTCTGGAGTGGA----CCTCCAGCAAACTGCAGCAGA CCTGCAGAAGAGGGGCCTGACTGTTA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAAGAAAAA-----------CTAACAAACAGAAAGCA ------------------------------------------------------------ ------------------------------------------------------------ --A-----------TAACATCAACATCAACAAAAAGGACCCCCACACAAAAACCCCAT-- ----------------------------------------------CCAAAGGTCATC-- ---------------------------------------AGCCTCAAAGAT--------- ---------CAAAG---------------------------------------------- -GTAGATAAATCCACGAAG----------------------------------------- ------------------------------------------------------------ -------------------------------TGAGGAAAAA-----CCAGCGCAAAAATG CTG-------------------------------------AAAATTCCA--------AAA ACCA----GAATGCCT-------------CTTC--TCCT--CCAA---A-TG-------- -------ATC----GCAACTCCTC-------------------TC-CAG---CAAGGGCA CAAAACT----GG------ATGGAGA---ATGAGTTTGACGAATTGACAGAAGT------ ------AGGC------------TTCAGAAGGTGGGT-AATAACAAACTCCTCTGAGCT-- --AAAGGAGCATGTT--------------------------CTAACCCAATGC-----AA GGAAGCT---------------------------------------------AAGAACCT T-GATAAAA--------------------------------------------------- -GGTTACA----------GGAACTGCTAACTAGA-------------------------- -------------------------------------------ATAACCAGTTTAGAGAA ----------GAAC---------------ATAAATG------ACC---------TGATG- GAGC----TGAAA---------AACAC---AGCACGAGAACTTCGTGAAGCATACACA-- ---AGTATCAATAGCCGA----------------ATCG--------------------AT C--AAGC------------------GGAAGAAAG-GAT-ATCAG--AGATTGAAGAT--- -CAACTTAATGAAA-T-----AAAGCGTGAAG---------ACAAGATTAGA---GAAAA AAGA---ATGAAAAGG-AA---------CGA---ACAAAGCCTCC--AAGAAATATGGG- ACTAT--------G---TGAAAAG--ACCAAACCTACGA--T-TGATTGG--TGTA---- ----------CCTGAAAGTGACGGGGAGAATGGA---ACCAAGTTGG---------AAAA CACACTT---CA-----GGATATTATCCAG--GAGAACTTCCCCAACCT----------- ---------AGCAAGACAGGC--CAAC--ATTCAAATTC-----AGGAAATACAGAGA-A CACCACTAA------------GATACTC-CTC--------------AAGAAGAGCAACCC C-------A---------------------AGACACATAATCGTCAGATT------CTC- CAAGGTTGAAA---TGAAGG--AAAAAATGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGTCAGGT-------------- -----------TAC---CTACAAAGG-GAAGCCCA--------------TCAGACT--AA CAGCGGATCTC-----TCTGCAGAA--ACCCTA-CAAGC------CAG-AAGAGAGTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAATTT--TCA--ACCCAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCAT-AAGCGA-------AG-------- ------------------------G-AGAAATAAAATCCTTTACAGACAAGC-AAATGCT GAGGGA-TTTTGTCACCACCAGGC---CTGCCTTAC-AAGAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCAC--------------TAAATA TGG----------------------------------------------------AAAGG AAAA---------------ACCGGTA---------------------------------- -------------------------------CCAGCCACTGCA----------------- ------------------------------------AAAACAT----------------- --------ACCAAAATAATAAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCAATGACAC-------------------------TATGA A-------------------------------------------------GAAACTGCAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CAACTAATGTGCA--------------AA---ATAACCA GCTAG------------------------------------------------------- ------------------------------------------------------------ -------------CATCATG---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCACACATA--ACAATATTAAC-CTTAAAT-------G-T AAAT--GGGCT--AAATGC---CCCAATT----------------AAAAGAC------AC AGAC--TGGCAA----ATTG---------GAT-------AAAG---AGTCAAGACCCAT- ---CGG-------TGT-GCTGTATT-CAGGAGACCCATCT-CACGT--GCAAAGACACAC A-TAGGCTCAAAATAAAGGGA---T------------GGAGG----A-ATATTTACCAAG C--------------AAATGG------AAAGCAA-------------------AAAAAAA AAGCAG--GGGT----TGCAATCCTAGTCTC-TGATAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAAAGAC-AAAG-AAGGGCAT------TACAT------AAT GGTAAA---GGGATCAATG------CAACAA---GAAG--------AG-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAATACAGGAGCAC CCAG--ATT-CATAAAACAAGTTCTTAGAGACCT--AC----AAAGAGA---------CT TAGACTCCCAC------ACAATAATAGTGGGAGACTTTAACA----------------CC CCACT------GTCAAT-ATTAGACAGATCAA---------------------CGAGAC- -----AGAA-------------AATTAACAAGGATATTCAGGACTTGAAC-TCAGCTCTG GA------CCAAGCGG---ACCTAATAGACATCTACA--GA----ACTCTCCACCCCAAA TC---AACAGAATATACAT------TCTTCTCAGCAC-----CA--CAT-AGCACTTATT --C----TAAAATCGACCACATAATTGGAAGTAAAACACT-------------------- -CCTCAGCAAATGCAAAAGAA--CGGAAAT----------------CATAACAA------ -ACAGTCTCTCA---GACCACAGTGCAA-TCAAATTAGAACTCAGG-------------- ----------------------------------------------ATTA--------AG --------------AAA-CTCACTCA---AAACCGCACAA----CTACATGGAAA--C-T GAACAACCTG-CTCCTGAA---TG-ACTACTG--GGTAAATAACGA--AAT--T-AAGGC AGAAATA---------------AAGAAGTTCTTT---GAAAC------------------ ------CAATGAGAACAA-AGA------------CACAAC--GTACCAGAATCTC-TGG- GA-----CACAGCTAAAGCAGTG-----------------------------TTAAGAGG GAAA--TTTATAGCACTA----AATGC----CCACATCAGAAAGC---GGGAAAGATCT- --AAAATCGAC-ACCCTAA-CATCACAATTA---AAAGAAC--TAGAGAAGC------AA GA-----GCAAACAAATT-------------CAAAAGC--TAGCAGAA-GACAAGAAATA ACT---AAGATCAGA-------------------GCAGAACTG---AA-G-GAGATAGAG ACACG------AA------------------------------------AAA-CCC---T TCAAAAAATC-A---------ATG----AATCCA-GGAGCTG------GTTTTTTGAAAA GATTAA------------------------------------------------------ --------------------------------CAA-----AATAGATAGACCG---CTAG CCA------GACTAA--TAA------------AGAAG------------------AAAAG A---GAGA-AGAATC-----------------AAATAGA--------CACAA-----TA- ---------AAA-AATGATA--AA----------GGGGA---TATCACCACTGATCCC-A CA-GAAATA--CAAACTAC-CATCAG---------AGAATACT--ATAAA---------- -----------CAC---CTCTACGCAAATAA---ACTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----ACCCTCCCA----- -AGACTAAACCA---GGAAGAAGTCGAATCCCTGAAT----------------------- AGACC------------AA-TAACAAGTTCTGAAATTGAGG-C---------AGTAAT-- -TAATAGCCTACC------AACCAAAAAAAG---CCCAGGACC--AGACGG--------- ------------ATTCACA-GCCG--AA-------------------TTCTA-------- ----CCAGAGGTAC---AAAGAG-GAGCTGG--TA-CCATTC----------CTTCTGAA ACTATT----CC---AAACAATAGAA------AAAGAG-GG-----------ACTCCTCC CTAACTCATTTT-----ATGAGGCC-----AGCAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CTGGC AGA---------------------GAC---ACAACAAAAAA---AGAAAATTTC------ -------------A-GGCCAATAT---CCC----TGATGAACATCGAT------------ ------------GCGAAAATCC-TCA--------------------A----TAAAATACT GGC-AAACCG------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTTATCCA--CCACGAT------------C AAG---TCGGC-TT----------CATCCCT------------GG--GATGCAAGGCTGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--CGTA ---ATCCATCACAT------AAACAG----AACCAATGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCCTTCGATAA---AATTCAACACCCCTT- ---------------CATGC---------T---A--AA-----AACTCTCAAT---AAAC TAGGTATTGATGGAACAT-----ATCTCAAAATAATAAG--------------------- ------AGCTATTTAT-GACAAA--------CCCATAGC-----------CAATAT--CA TACTGAATGGGCA-----AAA-GCTGGAAGC----ATTC---CCT----TT--GAAAACC GGCACA----AGACAAGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ATT---GGAAGTTCTGGCCAGGGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAGGGTATTCAAATAGGA---AGAGAG------GAAGTCAAA--T--------- ------TGTCTCTG-TT--T---GCAGA------TGACAT------GATTGTATATTTA- -GAAAACC--CCATCGT---CTCAGCCC---------A---------------AA--AAC TCCTTAAGCT---------GA--TAAGCAACTTCAGCAAAG--TCT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- GCAAAAAT----CACA-------------------------------------------- -----AGCATTCC--TA-TACACCAAT---------------AATAGACAAG-----CAG A------------------GAGCCAAATC-ATG----AGTGAACTCCCATTCACAATTGC TACA------------------AAGAGAATA---------AAA------TACCTAGGAAT ACAACT--------TA--C-AAGGGATGTG---A---AGGACCTCT---TCAA-GGAGAA CTACAAACCAC------TGCTC-AAGGAAATAA-GA------------GAGG-------- ------------ACAC--AAAC--AAA---TGGA---AA--AACAT---------TCCA- --TGCTC------ATG-GATAGGAAGAATC-A---A---TATC--------------G-- TGAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--AGTAATTTATA-------------------GA---TTCAATGCT---ATT-- ------C-CCATCAAGCT--A---------------------CCATTG-AC---TTTCTT ------------------------------------------CACAGAATTAG------- ----------------------AAAAAACTAC------TTTAAAT---TTCATATGGAAC C-------AAAAAAGAGCCC---GT--ATAGCCAAGACAATCCTAAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACG---CTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---CAAAACAGATA--- ---TATAGAC--CA---ATGG-AACAGAACAGAGGCCTC------AG---AAATAACA-- -CCAC----------------ACA-------TCTACAA----CCATCT--GATCTTC--- GACAAA--CCTGACAAAAACAAGC--A-------------------ATGGG--GA---AA GG------------ATTCCCTATT--TAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-CTAGCCA---------------TATGC-AGAAAA---CTG ---------AAACTGGACCCC---TTCCT-----------TACACC--TTA--T---ACA AAAA-TTAACT-CAAGATGG---AT---TAAAGAC---TTAAATGTA--AAACCTAAAAC CAT------------------------AAAAACCCTAGAA---------------GAAAA ---CCTA------G------------------G-CAATACCATTCAGGACATAG--GCA- -----TGGGCAAAGACT-----TCATGACTAA-AACACCA---AAAGCAATTGCAAC--- --AAAAGCC---AA----AAT---TGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAT-------------CATCAGAGTGAACAG------------------- ------G-------------CAACCT------ACAGAA--T-GGGAG---AAAATTTTT- --GCAATCTATCCAT--------CT-------GACAAAGGTC--------TA--ATATC- ---CAGAATCTACAAG-GA--ACTTAA---ACA------AA--TTTAC------------ ---AAG--------------AAAAAAACA---AAC--AACCCCA-TCAA---AAAGTGGG C--GAA---------GGA--TATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATTT---AT-GCGGCCAAC--AAACATATGAAAA AAA----------GCTCATCATCACTG-GTCATTA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACGCCAGTTAGAATGGCGATCAT---T A--AAAAG-------TCAGGAA-----ACAACA-GATG--C------------------- ------TGGA-GAGGATGTG----------GAGAA------------------------- ------------ATAGGAACGCTTTT-ACACTGTTGG--TGGG----------------- ----------AGTGT--A-------------AATT---AGTTC----AACCATTGTGG-- ------AAGACAGTG--TGGCG--A-TTCCTC--AAGGATCTAGAA--CCAGAAATACC- -ATTT---GA--CCCAGCAATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAT------------TATAAATCA----T------- --------------TCTACTAT--AAAGACACATGC---------ACACG----TATGTT TATT--GCAGCACTATTTACAA-TAGCAAAGACTT--G--GA--ACCA--ACCCAA---A TGCCCATCA---ATGATAG-----ACTGGATAAAG--AAAA----TG------------- -----TGGCA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AAGAATGAGTTCATGTCCTTT---- ------------------------------------------------------------ --------GCAGGGACATGGATGAAG-C---TGGAAACCATCATTCTCAGCAA------- ------------------------------------------------ACTAACACAGGA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAACAC-CG-------- ---CAT---GTTCTCACTCAT----------AAGTGGGAGTTT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAACA-------ATGAGAA---------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GGA--------GGGGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----ATCACAC-----------------------------------------------A CCG-------GGGCCTGTCG----------------GGGGGTGGGGGGCAAGGGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GAGCATTAGGACAAATACCTAATGCATGCG GGGCTTAAAACCTAGATGACG--------------------------------------- ------------------------------------------------------------ ---------------------------------GGTTGATAGGTG--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAGCAAACCACCATGGCA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -CATGTAT-ACCTATGT------------------------------------------- --------------------------------------------AACAAA---------- -------------------CCTGCACGTTCTGCACATGTATCCCA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAACTTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GTAAAATAAAAAAAAA--------------------------------------- ------ >L1PA6 ------------------------------------------------------------ ------------------------------------------------------------ --------------CCGTTCCAAG-----------------ATGGCCGAATAGGAACAGC TCTGGTCTG---------------------------CAGCTCCCAGCGTG---------- ---------------------------------------ATCGACGCAGAAGACGG---- -----------GTGATTTCTGCATTTCCAACTGAGGTACCTGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------TTCATCTCATTGGG------ACTGGTTGGAC-------AGTGGG TGCA--------------GCCCATGGAGGGCGAG---------C-CGAAGCAGGGCGGGG CGTCGCCTCACCCG----------GGAAGTG----------------------------- -------------------------------------------------CAAGGGGTCGG GGGATTTCCCTTTCCTAGCCAAGGGAAGCCGTGA-----CA---GACTGTACCTGGAAAA ACGGGACACTCCCGCCCAAATACTGCGCTTTTC-------------------CCATGGTC TTAGCAACCGGCAGACCAGGAGATTCTCTCCCGTGCCTG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCTCGGTGGGTCC---------------- -------------------------CACGCCCACGGAGCCTTGCTCACTGCTAGCGCAGC AGTCTGAGATCGACCT-------------------------------------------- ------------------------------------------------------------ --GCGAGGCTGCAGCCTGGTGGGGGGAGGGGC-------------GTCCGCCATTGCTGA GGCTTGAGTAGGTAA--------------------------------------------- ---------------------------------------ACAAAGCGGCCAGGAAGCTCG AA-------------------CTGGGTGGAGCCCACCGCAG------------------- ------------------------------------------------------------ ----CTCAGCAAGGCC-------------------------------------------- ------------------------------------------------------------ ----------------------------------------TA-CTGCCTCTATAGACT-- ---------CCACCTCTGTGGGCAGGGCATAGCTGAAC-AAAAGGCAGCAGAAAC----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TTCTGCAGAC-------TTAAACGTCCCTGTCTGACAGCT CTGAAGAGAGCAGTGGT------------------------------------------- --------------------TCTCCCAGCATGGCG------------------------- --------------------------TTTGAGCTCTGAGAATGGACAGACTGCCTCCTCA AGTGG-GT-------CCCTGACCCCCGTGTAGCCTAACT--------------------- ------------------------------------------------------------ --------------------------------------------GGGAGACACCTCCCAG TAG-------GGGCCGACAGACACCTCATACAGGCGGGTGCCCCTCTGGGACGAAGCTTC C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----AGAGGAAGG--------------------------------ATCAGGCAGCAATA TT------------TGCTGTTCTGCAATATTTGCTGTTCTGCAGCCTCCGCTGG------ ------------------------------------------------------------ ------------------------------------------------------------ ----TGATACCCAGGCAAACAGGGTCTGGAGTGGA----CCTCCAGCAAACTCCAACAGA CCTGCAGCTGAGGGACCTGACTGTTA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAAGGAAAA-----------CTAACAAACAGAAAGGA ------------------------------------------------------------ --------------------------ATAGCATCAACATCAACAAAA------------- --A-----------GGACATCCACACCAAAACCCCAT----------------------- ----------------------------------------------CTGTAGGTCACC-- ---------------------------------------AACATCAAAGAC--------- ---------CAAAG---------------------------------------------- -GTAGATAAAACCACAAAG----------------------------------------- ------------------------------------------------------------ -------------------------------TGGGGAGAAA-----CCAGAGCAGAAAAG CTG-------------------------------------AAAATTCTA--------AAA ACCA----GAGCGCCT-------------CTTC--TCCT--CCAA---A-GG-------- -------ATC----GCAGCTCCTC-------------------GC-CAG---CAACGGAA CAAAGCT----GG------ACGGAGA---ATGACTTTGACGAGTTGACAGAAGT------ ------AGGC------------TTCAGAAGGTCGGT-AATAACAAACTTCTCCGAGCT-- --AAAGGAGCATGTT--------------------------CTAACCCATCGC-----AA GGAAGCT---------------------------------------------AAAAACCT T-GAAAAAA--------------------------------------------------- -GGTTAGA----------CGAATGGCTAACTAGA-------------------------- -------------------------------------------ATAAACAGTGTAGAGAA ----------GACC---------------TTAAATG------ACC---------TGATG- GAGC----TGAAA---------ACCAT---GGCACGAGAACTTCGTGACGCATGCACA-- ---AGCTTCAATAGCCGA----------------TTCG--------------------AT C--AAGT------------------GGAAGAAAG-GAT-ATCAG--TGATTGAAGAT--- -CAAATTAATGAAA-T-----AAAGCGAGAAG---------ACAAGTTTAGA---GAAAA AAGA---GTAAAAAGA-AA---------TGA---ACAAAGCCTCC--AAGAAATATGGG- ACTAT--------G---TGAAAAG--ACCAAATCTACGT--T-TGATTGG--TGTA---- ----------CCTGAAAGTGACGGGGAGAATGGA---ACCAAGTTGG---------AAAA CACTCTT---CA-----GGATATTATCCAG--GAGAACTTCCCCAACCT----------- ---------AGCAAGGCAGGC--CAAC--ATTCAAATTC-----AGGAAATACAGAGA-A CACCACAAA------------GATACTC-CTC--------------GAGAAGAGCAACCC C-------A---------------------AGACACATAATTGTCAGATT------CAC- CAAGGTTGAAA---TGAAGG--AAAAAATGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGTCGGGT-------------- -----------TAC---CCACAAAGG-GAAGCCCA--------------TCAGACT--AA CAGCGGATCTC-----TCGGCAGAA--ACCCTA-CAAGC------CAG-AAGAGAGTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAATTT--TCA--ACCCAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCAT-AAGTGA-------AG-------- ------------------------G-AGAAATAAAATCCTTTACAGACAAGC-AAATGCT GAGAGA-TTTTGTCACCACCAGGC---CTGCCTTAC-AAGAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCAC--------------TAAACA TGG----------------------------------------------------AAAGG AACA---------------ACCGGTA---------------------------------- -------------------------------CCAGCCACTGCA----------------- ------------------------------------AAAACAT----------------- --------GCCAAATTGGTAAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCATCGATGC-------------------------TATGA A-------------------------------------------------GAAACTGCAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CAATTAACGGGCA--------------AA---ATAACCA GCTAA------------------------------------------------------- ------------------------------------------------------------ -------------CATCATA---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCACACATA--ACAATATTAAC-CTTAAAT-------G-T AAAT--GGGCT--AAATGC---CCCAATT----------------AAAAGAC------AC AGAC--TGGCAA----ATTG---------GAT-------AAAG---AGTCAAGACCCAT- ---CAG-------TGT-GCTGTATT-CAGGAGACCCATCT-CACGT--GCAGAGACACAC A-TAGGCTCAAAATAAAGGGA---T------------GGAGG----A-AGATCTACCAAG C--------------AAATGG------AAAGCAAAAAAAAAAAAAAAAAAAAAAAAAA-A AAGCAG--GGGT----TGCAATCCTAGTCTC-TGATAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAGAGAC-AAAG-AAGGCCAT------TACAT------AAT GGTAAA---GGGATCAATT------CAACAA---GAAG--------AG-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAATACAGGAGCAC CCAG--ATT-CATAAAGCAAGTCCTTAGAGACCT--AC----AAAGAGA---------CT TAGACTCCCAC------ACAATAATAATGGGAGACTTTAACA----------------CC CCACT------GTCAAT-ATTAGACAGATCAA---------------------CGAGAC- -----AGAA-------------GGTTAACAAGGATATCCAGGACTTGAAC-TCAGCTCTG CA------CCAAGCGG---ACCTAATAGACATCTACA--GA----ACTCTCCACCCCAAA TC---AACAGAATATACAT------TCTTCTCAGCAC-----CA--CAT-CGCACTTATT --C----CAAAATTGACCACATAGTTGGAAGTAAAGCACT-------------------- -CCTCAGCAAATGTAAAAGAA--CAGAAAT----------------CACAACAA------ -ACTGTCTCTCA---GACCACAGTGCAA-TCAAATTAGAACTCAGG-------------- ----------------------------------------------ATTA--------AG --------------AAA-CTCACTCA---AAACCGCACAA----CTACATGGAAA--C-T GAACAACCTG-CTCCTGAA---TG-ACTACTG--GGTAAATAACGA--AAT--G-AAGGC AGAAATA---------------AAGATGTTCTTT---GAAAC------------------ ------CAATGAGAACAA-AGA------------CACAAC--GTACCAGAATCTC-TGG- GA-----CACATTTAAAGCAGTG-----------------------------TGTAGAGG GAAA--TTTATAGCACTA----AATGC----CCACAAGAGAAAGC---AGGAAAGATCT- --AAAATCGAC-ACCCTAA-CATCACAATTA---AAAGAAC--TAGAGAAGC------AA GA-----GCAAACAAATT-------------CAAAAGC--TAGCAGAA-GGCAAGAAATA ACT---AAGATCAGA-------------------GCAGAACTG---AA-G-GAGATAGAG ACACA------AA------------------------------------AAA-CCC---T TCAAAAAATC-A---------ATG----AATCCA-GGAGCTG------GTTTTTTGAAAA GATCAA------------------------------------------------------ --------------------------------CAA-----AATTGATAGACCG---CTAG CAA------GACTAA--TAA------------AGAAG------------------AAAAG A---GAGA-AGAATC-----------------AAATAGA--------CGCAA-----TA- ---------AAA-AATGATA--AA----------GGGGA---TATCACCACCGATCCC-A CA-GAAATA--CAAACTAC-CATCAG---------AGAATACT--ATAAA---------- -----------CAC---CTCTACGCAAATAA---ACTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----ACCCTCCCA----- -AGACTAAACCA---GGAAGAAGTTGAATCTCTGAAT----------------------- AGACC------------AA-TAACAGGCTCTGAAATTGAGG-C---------AATAAT-- -TAATAGCCTACC------AACCAAAAAAAG---TCCAGGACC--AGACGG--------- ------------ATTCACA-GCCG--AA-------------------TTCTA-------- ----CCAGAGGTAC---AAAGAG-GAGCTGG--TA-CCATTC----------CTTCTGAA ACTATT----CC---AATCAATAGAA------AAAGAG-GG-----------AATCCTCC CTAACTCATTTT-----ATGAGGCC-----AGCAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAGC-------CTGGC AGA---------------------GAC---ACAACAAAAAA---AGAGAATTTT------ -------------A-GACCAATAT---CCC----TGATGAACATCGAT------------ ------------GCGAAAATCC-TCA--------------------A----TAAAATACT GGC-AAACCG------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTTATCCA--CCACGAT------------C AAG---TCGGC-TT----------CATCCCT------------GG--GATGCAAGGCTGG -T----------------------TC-AAC-----ATACGC--AAATCAATAAA--CGTA ---ATCCATCACAT------AAACAG----AACCAACGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCCTTCGACAA---AATTCAACAGCCCTT- ---------------CATGC---------T---A--AA-----AACTCTCAAT---AAAC TAGGTATTGATGGAACGT-----ATCTCAAAATAATAAG--------------------- ------AGCTATTTAT-GACAAA--------CCCACAGC-----------CAATAT--CA TACTGAATGGGCA-----AAA-ACTGGAAGC----ATTC---CCT----TT--GAAAACT GGCACA----AGACAGGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT GTT---GGAAGTTCTGGCCAGGGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAGGGTATTCAATTAGGA---AAAGAG------GAAGTCAAA--T--------- ------TGTCCCTG-TT--T---GCAGA------TGACAT------GATTGTATATTTA- -GAAAACC--CCATCGT---CTCAGCCC---------A---------------AA--ATC TCCTTAAGCT---------GA--TAAGCAACTTCAGCAAAG--TCT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- GCAAAAAT----CACA-------------------------------------------- -----AGCATTCC--TA-TACACCAAT---------------AACAGACAAA-----CAG A------------------GAGCCAAATC-ATG----AGTGAACTCCCATTCACAATTGC TACA------------------AAGAGAATA---------AAA------TACCTAGGAAT CCAACT--------TA--C-AAGGGATGTG---A---AGGACCTCT---TCAA-GGAGAA CTACAAACCAC------TGCTC-AACGAAATAA-AA------------GAGG-------- ------------ACAC--AAAC--AAA---TGGA---AG--AACAT---------TCCA- --TGCTC------ATG-GATAGGAAGAATC-A---A---TATC--------------G-- TGAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--GGTAATTTATA-------------------GA---TTCAATGCC---ATC-- ------C-CCATCAAGCT--A---------------------CCAATG-AC---TTTCTT ------------------------------------------CACAGAATTGG------- ----------------------AAAAAACTAC------TTTAAAG---TTCATATGGAAC C-------AAAAAAGAGCCC---GC--ATTGCCAAGACAATCCTAAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACG---CTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---CAAAACAGAGA--- ---TATAGAC--CA---ATGG-AACAGAACAGAGGCCTC------AG---AAATAACA-- -CCAC----------------ACA-------TCTACAA----CCATCT--GATCTTT--- GACAAA--CCTGACAAAAACAAGA--A-------------------ATGGG--GA---AA GG------------ATTCCCTATT--TAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-CTAGCCA---------------TATGT-AGAAAG---CTG ---------AAACTGGATCCC---TTCCT-----------TACACC--TTA--T---ACA AAAA-TTAATT-CAAGATGG---AT---TAAAGAC---TTAAATGTT--AGACCTAAAAC CAT------------------------AAAAACCCTAGAA---------------GAAAA ---CCTA------G------------------G-CAATACCATTCAGGACATAG--GCA- -----TGGGCAAGGACT-----TCATGACTAA-AACACCA---AAAGCAATGGCAAC--- --AAAAGCC---AA----AAT---AGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAC-------------CATCAGAGTGAACAG------------------- ------G-------------CAACCT------ACAGAA--T-GGGAG---AAAATTTTT- --GCAATCTACCCAT--------CT-------GACAAAGGGC--------TA--ATATC- ---CAGAATCTACAAA-GA--ACTTAA---ACA------AA--TTTAC------------ ---AAG--------------AAAAAAACA---AAC--AACCCCA-TCAA---AAAGTGGG C--AAA---------GGA--TATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATTT---AT-GCAGCCAAC--AGACACATGAAAA AAT----------GCTCATCATCACTG-GTCATCA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACACCAGTTAGAATGGCGATCAT---T A--AAAAG-------TCAGGAA-----ACAACA-GATG--C------------------- ------TGGA-GAGGATGTG----------GAGAA------------------------- ------------ATAGGAACGCTTTT-ACACTGTTGG--TGGG----------------- ----------AGTGT--A-------------AACT---AGTTC----AACCATTGTGG-- ------AAGACAGTG--TGGCG--A-TTCCTC--AAGGATCTAGAA--CTAGAAATACC- -ATTT---GA--CCCAGCCATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAT------------TATAAATCA----T------- --------------GCTACTAT--AAAGACACATGC---------ACACG----TATGTT TATT--GCGGCACTATTCACAA-TAGCAAAGACTT--G--GA--ACCA--ACCCAA---A TGTCCATCA---ATGATAG-----ACTGGATTAAG--AAAA----TG------------- -----TGGCA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AAGGATGAGTTCATGTCCTTT---- ------------------------------------------------------------ --------GCAGGGACATGGATGAAG-C---TGGAAACCATCATTCTGAGCAA------- ------------------------------------------------ACTATCACAAGG ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAACAC-CG-------- ---CAT---GTTCTCACTCAT----------AGGTGGGAATTT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAACA-------ATGAGAA---------------CAC--------T-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GGC--------GGGGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----ATCACAC-----------------------------------------------A CCG-------GGGCCTGTCG----------------GGGGGTGGGGGGCTGGGGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TAGCATTAGGAGAAATACCTAATG-TAAAT GACG-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------AGTTGATGGGTG--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAGCAAACCAACATGGCA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -CATGTAT-ACCTATGT------------------------------------------- --------------------------------------------AACAAA---------- -------------------CCTGCACGTTGTGCACATGTACCCTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAACTTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GTATAATAAAAAAAAAAAA------------------------------------ ------ >L1PA3 ------------------------------------------------------------ ------------------------------------------------------------ ----------GGGGGGCAGCCAAG-----------------ATGGCCGAATAGGAACAGC TCCGGTCTA---------------------------CAGCTCCCAGCGTG---------- ---------------------------------------AGCGACGCAGAAGACGG---- -----------GTGATTTCTGCATTTCCATCTGAGGTACCGGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------TTCATCTCACTAGG------GAGTGCCAGAC-------AGTGGG CGCAGGACAGTGGGTGCAGCGCACCGTGCGCGAG---------C-CGAAGCAGGGCGAGG CATTGCCTCACTCG----------GGAAGCG----------------------------- -------------------------------------------------CAAGGGGTCAG GGAG-TTCCCTTTCCTAGTCAAAGAAAGGGGTGA-----CA---GACGGCACCTGGAAAA TCGGGTCACTCCCACCCTAATACTGCGCTTTTC-------------------CGACGGGC TTAAAAAACGGCGCACCAGGAGATTATATCCCGCACCTG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCTCGGAGGGTCC---------------- -------------------------TACGCCCACGGAGTCTCGCTGATTGCTAGCACAGC AGTCTGAGATCAAACT-------------------------------------------- ------------------------------------------------------------ --GCAAGGCGGCAGCGAGGCTGGGGGAGGGGC-------------GCCCGCCATTGCCCA GGCTTGCTTAGGTAA--------------------------------------------- ---------------------------------------ACAAAGCAGCCGGGAAGCTCG AA-------------------CTGGGTGGAGCCCACCACAG------------------- ------------------------------------------------------------ ----CTCAAGGAGGCC-------------------------------------------- ------------------------------------------------------------ ----------------------------------------TGCCTGCCTCTGTAGGCT-- ---------CCACCTCTGGGGGCAGGGCACAGACAAACAAAAAGACAGCAGTAAC----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CTCTGCAGAC-------TTAAATGTCCCTGTCTGACAGCT TTGAAGAGAGCAGTGGT------------------------------------------- --------------------TCTCCCAGCACGCAG------------------------- --------------------------CTGGAGATCTGAGAACGGGCAGACTGCCTCCTCA AGTGG-GTCCCTGACCCCTGACCCCCGAGCAGCCTAACT--------------------- ------------------------------------------------------------ --------------------------------------------GGGAGGCACCCCCCAG TAG-------GGGCAGACTGACACCTCACACGGCCGGGTACTCCTCTGAGACAAAACTTC C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----AGAGGAACG--------------------------------ATCAGACAGCAGCA TT------------CGCGGTTCACGAAAATCCGCTGTTCTGCAGCCACCGCTGC------ ------------------------------------------------------------ ------------------------------------------------------------ ----TGATACCCAGGCAAACAGGGTCTGGAGTGGA----CCTCTAGCAAACTCCAACAGA CCTGCAGCTGAGGGTCCTGTCTGTTA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAAGGAAAA-----------CTAACAAACAG------ ------------------------------------------------------------ ---------------------------------------------AA------------- --A-----------GGACATCCACACCAAAAACCCAT----------------------- ----------------------------------------------CTGTACATCACC-- ---------------------------------------ATCATCAAAGAC--------- ---------CAAAA---------------------------------------------- -GTAGATAAAACCACAAAG----------------------------------------- ------------------------------------------------------------ --------------------------------AGGGAAAAA-----ACAGAGCAG-AAAA CTG-------------------------------------GAAACTCTA--------AAA AGCA----GAGCGCCT-------------CTCC--TCCT--CCAA---A-GG-------- -------AAC----GCAGTTCCTC-------------------AC-CAG---CAATGGAA CAAAGCT----GG------ACGGAGA---ATGACTTTGACGAGCTGAGAGAAGA------ ------AGGCACATATCTCAAATTCAGACGAT----------CAAACTACTCTGAGCT-- --ACAGGAGGAAATT--------------------------CAAACCAAAGGC-----AA AGAAGTT---------------------------------------------AAAAACTT T-GAAAAAA--------------------------------------------------- -AATTAGA----------CGAATGGATAACTAGA-------------------------- -------------------------------------------ATAACCAATGCAGAGAA ----------GGGCTACCCTCTCTCACCATTAAAGG------AGC---------TGATG- GAGC----TGAAA---------GCCAA---GGCTCGAGAACTACGTGAAGAATGCAGA-- ---AGCCTCAGTAGCCGA----------------TGCG--------------------AT C--AACT------------------GGAAGAAAG-GGT-ATCAG--CGATAGAAGAT--- -GAAATGAATGAAA-T-----GAAGCGAGAAG---------GGAAGTTTAGA---GAAAA AAGA---ATAAAAAGA-AA---------TGA---ACAAAGCCTCC--AAGAAATATGGG- ACTAT--------G---TGAAAAG--ACCAAATCTACGT--C-TGATTGG--TGTA---- ----------CCTGAAAGTGACGGGGAGAATGGA---ACCAAGTTGG---------AAAA CACTCTG---CA-----GGATATTATCCAG--GAGAACTTCCCCAATCT----------- ---------AGCAAGGCAGGC--CAAC--ATTCAGATTC-----AGGAAATACAGAGA-A CGCCACAAA------------GATACTC-CTC--------------GAGAAGAGCAACTC C-------A---------------------AGACACATAATTGTCAGATT------CAC- CAAAGTTGAAA---TGAAGG--AAAAAATGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGTCAGGT-------------- -----------TAC---CCACAAAGG-GAAGCCCA--------------TCAGACT--AA CAGCAGATCTC-----TCGGCAGAA--ACTCTA-CAAGC------CAG-AAGAGAGTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAATTT--TCA--ACCCAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCAT-AAGTGA-------AG-------- ------------------------G-AGAAATAAAATACTTTACAGACAAGC-AAATGCT GAGAGA-TTTTGTCACCACCAGGC---CTGCCCTAA-AAGAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCAC--------------TAAACA TGG----------------------------------------------------AAAGG AACA---------------ACCGGTA---------------------------------- -------------------------------CCAGCCACTGCA----------------- ------------------------------------AAAACAT----------------- --------GCCAAAATGGTAAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCATCGAGGC-------------------------TAGGA A-------------------------------------------------GAAACTGCAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CAACTAACGAGCA--------------AA---ATAACCA GCTAA------------------------------------------------------- ------------------------------------------------------------ -------------CATCATA---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCACACATA--ACAATATTAAC-TTTAAAT-------G-T AAAT--GGACT--AAATGC---TCCAATT----------------AAAAGAC------AC AGAC--TGGCAA----ATTG---------GAT-------AAAG---AGTCAAGACCCAT- ---CAG-------TGT-GCTGTATT-CAGGAAACCCATCT-CACGT--GCAGAGACACAC A-TAGGCTCAAAATAAAAGGA---T------------GGAGG----A-AGATCTACCAAG C--------------AAATGG------AAAAC---------------------AAAAA-A AGGCAG--GGGT----TGCAATCCTAGTCTC-TGATAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAGAGAC-AAAG-AAGGCCAT------TACAT------AAT GGTAAA---GGGATCAATT------CAACAA---GAAG--------AG-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAATACAGGAGCAC CCAG--ATT-CATAAAGCAAGTCCTGAGTGACCT--AC----AAAGAGA---------CT TAGACTCCCAC------ACAATAATAATGGGAGACTTTAACA----------------CC CCACT------GTCAAC-ATTAGACAGATCAA---------------------CGAGAC- -----AGAA-------------AGTTAACAAGGATACCCAGGAATTGAAC-TCAGCTCTG CA------CCAAGCGG---ACCTAATAGACATCTACA--GA----ACTCTCCACCCCAAA TC---AACAGAATATACAT------TTTTTTCAGCAC-----CA--CAC-CACACCTATT --C----CAAAATTGACCACATAGTTGGAAGTAAAGCTCT-------------------- -CCTCAGCAAATGTAAAAGAA--CAGAAAT----------------TATAACAA------ -ACTGTCTCTCA---GACCACAGTGCAA-TCAAACTAGAACTCAGG-------------- ----------------------------------------------ATTA--------AG --------------AAA-CTCACTCA---AAACCGCTCAA----CTACATGGAAA--C-T GAACAACCTG-CTCCTGAA---TG-ACTACTG--GGTACATAACGA--AAT--G-AAGGC AGAAATA---------------AAGATGTTCTTT---GAAAC------------------ ------CAACGAGAACAA-AGA------------CACAAC--ATACCAGAATCTC-TGG- GA-----CACATTCAAAGCAGTG-----------------------------TGTAGAGG GAAA--TTTATAGCACTA----AATGC----CCACAAGAGAAAGC---AGGAAAGATCC- --AAAATTGAC-ACCCTAA-CATCACAATTA---AAAGAAC--TAGAAAAGC------AA GA-----GCAAACACATT-------------CAAAAGC--TAGCAGAA-GGCAAGAAATA ACT---AAAATCAGA-------------------GCAGAACTG---AA-G-GAAATAGAG ACACA------AA------------------------------------AAA-CCC---T TCAAAAAATT-A---------ATG----AATCCA-GGAGCTG------GTTTTTTGAAAG GATCAA------------------------------------------------------ --------------------------------CAA-----AATTGATAGACCG---CTAG CAA------GACTAA--TAA------------AGAAG------------------AAAAG A---GAGA-AGAATC-----------------AAATAGA--------CGCAA-----TA- ---------AAA-AATGATA--AA----------GGGGA---TATCACCACCGATCCC-A CA-GAAATA--CAAACTAC-CATCAG---------AGAATACT--ACAAA---------- -----------CAC---CTCTACGCAAATAA---ACTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------CGACACA---------TAC-----ACCCTCCCA----- -AGACTAAACCA---GGAAGAAGTTGAATCTCTGAAT----------------------- AGACC------------AA-TAACAGGCTCTGAAATTGTGG-C---------AATAAT-- -CAATAGCTTACC------AACCAAAAAGAG---TCCAGGACC--AGATGG--------- ------------ATTCACA-GCCG--AA-------------------TTCTA-------- ----CCAGAGGTAC---AAGGAG-GAACTGG--TA-CCATTC----------CTTCTGAA ACTATT----CC---AATCAATAGAA------AAAGAG-GG-----------AATCCTCC CTAACTCATTTT-----ATGAGGCC-----AGCAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAGC-------CGGGC AGA---------------------GAC---ACAACCAAAAA---AGAGAATTTT------ -------------A-GACCAATAT---CCT----TGATGAACATTGAT------------ ------------GCAAAAATCC-TCA--------------------A----TAAAATACT GGC-AAACCG------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTTATCCA--CCATGAT------------C AAG---TGGGC-TT----------CATCCCT------------GG--GATGCAAGGCTGG -T----------------------TC-AAT-----ATACGC--AAATCAATAAA--TGTA ---ATCCAGCATAT------AAACAG----AACCAAAGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCCTTTGACAA---AATTCAACAACCCTT- ---------------CATGC---------T---A--AA-----AACTCTCAAT---AAAT TAGGTATTGATGGGACGT-----ATCTCAAAATAATAAG--------------------- ------AGCTATCTAT-GACAAA--------CCCACAGC-----------CAATAT--CA TACTGAATGGGCA-----AAA-ACTGGAAGC----ATTC---CCT----TT--GAAAACT GGCACA----AGACAGGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT GTT---GGAAGTTCTGGCCAGGGCAAT--------TAG-GC------AGGAG---AAGGA --AATAAAGGGTATTCAATTAGGA---AAAGAG------GAAGTCAAA--T--------- ------TGTCCCTG-TT--T---GCAGA------TGACAT------GATTGTATATCTA- -GAAAACC--CCATTGT---CTCAGCCC---------A---------------AA--ATC TCCTTAAGCT---------GA--TAAGCAACTTCAGCAAAG--TCT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- ACAAAAAT----CACA-------------------------------------------- -----AGCATTCT--TA-TACACCAAT---------------AACAGACAAA-----CAG A------------------GAGCCAAATC-ATG----AGTGAACTCCCATTCACAATTGC TTCA------------------AAGAGAATA---------AAA------TACCTAGGAAT CCAACT--------TA--C-AAGGGACGTG---A---AGGACCTCT---TCAA-GGAGAA CTACAAACCAC------TGCTC-AATGAAATAA-AA------------GAGG-------- ------------ATAC--AAAC--AAA---TGGA---AG--AACAT---------TCCA- --TGCTC------ATG-GGTAGGAAGAATC-A---A---TATC--------------G-- TGAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--GGTAATTTATA-------------------GA---TTCAATGCC---ATC-- ------C-CCATCAAGCT--A---------------------CCAATG-AC---TTTCTT ------------------------------------------CACAGAATTGG------- ----------------------AAAAAACTAC------TTTAAAG---TTCATATGGAAC C-------AAAAAAGAGCCC---GC--ATCGCCAAGTCAATCCTAAGCC---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACG---CTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---CAAAACAGAGA--- ---TATAGAT--CA---ATGG-AACAGAACAGAGCCCTC------AG---AAATAACG-- -CCGC----------------ATA-------TCTACAA----CTATCT--GATCTTT--- GACAAA--CCTGAGAAAAACAAGC--A-------------------ATGGG--GA---AA GG------------ATTCCCTATT--TAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-CTAGCCA---------------TATGT-AGAAAG---CTG ---------AAACTGGATCCC---TTCCT-----------TACACC--TTA--T---ACA AAAA-TTAATT-CAAGATGG---AT---TAAAGAC---TTAAACGTT--AGACCTAAAAC CAT------------------------AAAAACCCTAGAA---------------GAAAA ---CCTA------G------------------G-CAATACCATTCAGGACATAG--GCA- -----TGGGCAAGGACT-----TCATGTCTAA-AACACCA---AAAGCAATGGCAAC--- --AAAAGCC---AA----AAT---TGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAC-------------CATCAGAGTGAACAG------------------- ------G-------------CAACCT------ACAAAA--T-GGGAG---AAAATTTTC- --GCAACCTACTCAT--------CT-------GACAAAGGGC--------TA--ATATC- ---CAGAATCTACAAT-GA--ACTCAA---ACA------AA--TTTAC------------ ---AAG--------------AAAAAAACA---AAC--AACCCCA-TCAA---AAAGTGGG C--GAA---------GGA--CATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATTT---AT-GCAGCCAAA--AAACACATGAAAA AAT----------GCTCACCATCACTG-GCCATCA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACACCAGTTAGAATGGCGATCAT---T A--AAAAG-------TCAGGAA-----ACAACA-GGTG--C------------------- ------TGGA-GAGGATGTG----------GAGAA------------------------- ------------ATAGGAACACTTTT-ACACTGTTGG--TGGG----------------- ----------ACTGT--A-------------AACT---AGTTC----AACCATTGTGG-- ------AAGTCAGTG--TGGCG--A-TTCCTC--AGGGATCTAGAA--CTAGAAATACC- -ATTT---GA--CCCAGCCATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAC------------TATAAATCA----T------- --------------GCTGCTAT--AAAGACACATGC---------ACACG----TATGTT TATT--GCGGCACTATTCACAA-TAGCAAAGACTT--G--GA--ACCA--ACCCAA---A TGTCCAACA---ATGATAG-----ACTGGATTAAG--AAAA----TG------------- -----TGGCA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AATGATGAGTTCATGTCCTTT---- ------------------------------------------------------------ --------GTAGGGACATGGATGAAA-C---TGGAAATCATCATTCTCAGTAA------- ------------------------------------------------ACTATCGCAAGG ACAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAACAC-CG-------- ---CAT---GTTCTCACTCAT----------AGGTGGGAATTT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAACA-------ATGAGAA---------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GAA--------GGGGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----ATCACAC-----------------------------------------------T CTG-------GGGACTGTTG----------------TGGGGTGGGGGGAGGGGGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TAGCATTAGGAGATATACCTAATGCTAAAT GACG-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------AGTTAATGGGTG--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAGCACACCAGCATGGCA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -CATGTAT-ACATATGT------------------------------------------- --------------------------------------------AACTAA---------- -------------------CCTGCACATTGTGCACATGTACCCTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAACTTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GTATAATAATAATAAAATA------------------------------------ ------ >L1HS ------------------------------------------------------------ ------------------------------------------------------------ ----------GGGGAGGAGCCAAG-----------------ATGGCCGAATAGGAACAGC TCCGGTCTA---------------------------CAGCTCCCAGCGTG---------- ---------------------------------------AGCGACGCAGAAGACGG---- -----------GTGATTTCTGCATTTCCATCTGAGGTACCGGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------TTCATCTCACTAGG------GAGTGCCAGAC-------AGTGGG CGCAGGCCAGTGTGTGT-GCGCACCGTGCGCGAG---------C-CGAAGCAGGGCGAGG CATTGCCTCACCTG----------GGAAGCG----------------------------- -------------------------------------------------CAAGGGGTCAG GGAG-TTCCCTTTCCGAGTCAAAGAAAGGGGTGA-----CG---GAC-GCACCTGGAAAA TCGGGTCACTCCCACCCGAATATTGCGCTTTTC-------------------AGACCGGC TTAAGAAACGGCGCACCACGAGACTATATCCCACACCTG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCTCAGAGGGTCC---------------- -------------------------TACGCCCACGGAATCTCGCTGATTGCTAGCACAGC AGTCTGAGATCAAACT-------------------------------------------- ------------------------------------------------------------ --GCAAGGCGGCAACGAGGCTGGGGGAGGGGC-------------GCCCGCCATTGCCCA GGCTTGCTTAGGTAA--------------------------------------------- ---------------------------------------ACAAAGCAGCCGGGAAGCTCG AA-------------------CTGGGTGGAGCCCACCACAG------------------- ------------------------------------------------------------ ----CTCAAGGAGGCC-------------------------------------------- ------------------------------------------------------------ ----------------------------------------TGCCTGCCTCTGTAGGCT-- ---------CCACCTCTGGGGGCAGGGCACAGACAAACAAAAAGACAGCAGTAAC----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CTCTGCAGAC-------TTAAGTGTCCCTGTCTGACAGCT TTGAAGAGAGCAGTGGT------------------------------------------- --------------------TCTCCCAGCACGCAG------------------------- --------------------------CTGGAGATCTGAGAACGGGCAGACTGCCTCCTCA AGTGG-GTCCCTGACCCCTGACCCCCGAGCAGCCTAACT--------------------- ------------------------------------------------------------ --------------------------------------------GGGAGGCACCCCCCAG CAG-------GGGCACACTGACACCTCACACGGCAGGGT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ATTCCAACAGA CCTGCAGCTGAGGGTCCTGTCTGTTA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAAGGAAAA-----------CTAACAACCAG------ ------------------------------------------------------------ ---------------------------------------------AA------------- --A-----------GGACATCTACACCGAAAACCCAT----------------------- ----------------------------------------------CTGTACATCACC-- ---------------------------------------ATCATCAAAGAC--------- ---------CAAAA---------------------------------------------- -GTAGATAAAACCACAAAG----------------------------------------- ------------------------------------------------------------ -------------------------------TGGGGAAAAA-----ACAGAACAGAAAAA CTG-------------------------------------GAAACTCTA--------AAA CGCA----GAGCGCCT-------------CTCC--TCCT--CCAA---A-GG-------- -------AAC----GCAGTTCCTC-------------------AC-CAG---CAACAGAA CAAAGCT----GG------ATGGAGA---ATGATTTTGACGAGCTGAGAGAAGA------ ------AGGC------------TTCAGACGAT----------CAAATTACTCTGAGCT-- --ACGGGAGGACATT--------------------------CAAACCAAAGGC-----AA AGAAGTT---------------------------------------------GAAAACTT T-GAAAAAA--------------------------------------------------- -ATTTAGA----------AGAATGTATAACTAGA-------------------------- -------------------------------------------ATAACCAATACAGAGAA ----------GTGC---------------TTAAAGG------AGC---------TGATG- GAGC----TGAAA---------ACCAA---GGCTCGAGAACTACGTGAAGAATGCAGA-- ---AGCCTCAGGAGCCGA----------------TGCG--------------------AT C--AACT------------------GGAAGAAAG-GGT-ATCAG--CAATGGAAGAT--- -GAAATGAATGAAA-T-----GAAGCGAGAAG---------GGAAGTTTAGA---GAAAA AAGA---ATAAAAAGA-AA---------TGA---GCAAAGCCTCC--AAGAAATATGGG- ACTAT--------G---TGAAAAG--ACCAAATCTACGT--C-TGATTGG--TGTA---- ----------CCTGAAAGTGATGTGGAGAATGGA---ACCAAGTTGG---------AAAA CACTCTG---CA-----GGATATTATCCAG--GAGAACTTCCCCAATCT----------- ---------AGCAAGGCAGGC--CAAC--GTTCAGATTC-----AGGAAATACAGAGA-A CGCCACAAA------------GATACTC-CTC--------------GAGAAGAGCAACTC C-------A---------------------AGACACATAATTGTCAGATT------CAC- CAAAGTTGAAA---TGAAGG--AAAAAATGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGTCGGGT-------------- -----------TAC---CCTCAAAGG-AAAGCCCA--------------TCAGACT--AA CAGCGGATCTC-----TCGGCAGAA--ACCCTA-CAAGC------CAG-AAGAGAGTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAATTT--TCA--ACCCAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCAT-AAGTGA-------AG-------- ------------------------G-AGAAATAAAATACTTTATAGACAAGC-AAATGTT GAGAGA-TTTTGTCACCACCAGGC---CTGCCCTAA-AAGAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCGC--------------TAAACA TGG----------------------------------------------------AAAGG AACA---------------ACCGGTA---------------------------------- -------------------------------CCAGCCGCTGCA----------------- ------------------------------------AAATCAT----------------- --------GCCAAAATGGTAAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCATCGAGAC-------------------------TAGGA A-------------------------------------------------GAAACTGCAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CAACTAATGAGCA--------------AA---ATCACCA GCTAA------------------------------------------------------- ------------------------------------------------------------ -------------CATCATA---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCACACATA--ACAATATTAAC-TTTAAAT-------A-T AAAT--GGACT--AAATTC---TGCAATT----------------AAAAGAC------AC AGAC--TGGCAA----GTTG---------GAT-------AAAG---AGTCAAGACCCAT- ---CAG-------TGT-GCTGTATT-CAGGAAACCCATCT-CACGT--GCAGAGACACAC A-TAGGCTCAAAATAAAAGGA---T------------GGAGG----A-AGATCTACCAAG C--------------CAATGG------AAAAC---------------------AAAAA-A AGGCAG--GGGT----TGCAATCCTAGTCTC-TGATAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAGAGAC-AAAG-AAGGCCAT------TACAT------AAT GGTAAA---GGGATCAATT------CAACAA---GAGG--------AG-CTAACTA-TCC TAA-----------------A----TATTTATG---------CACCCAATACAGGAGCAC CCAG--ATT-CATAAAGCAAGTCCTGAGTGACCT--AC----AAAGAGA---------CT TAGACTCCCAC------ACATTAATAATGGGAGACTTTAACA----------------CC CCACT------GTCAAC-ATTAGACAGATCAA---------------------CGAGAC- -----AGAA-------------AGTCAACAAGGATACCCAGGAATTGAAC-TCAGCTCTG CA------CCAAGCAG---ACCTAATAGACATCTACA--GA----ACTCTCCACCCCAAA TC---AACAGAATATACAT------TTTTTTCAGCAC-----CA--CAC-CACACCTATT --C----CAAAATTGACCACATAGTTGGAAGTAAAGCTCT-------------------- -CCTCAGCAAATGTAAAAGAA--CAGAAAT----------------TATAACAA------ -ACTATCTCTCA---GACCACAGTGCAA-TCAAACTAGAACTCAGG-------------- ----------------------------------------------ATTA--------AG --------------AAT-CTCACTCA---AAGCCGCTCAA----CTACATGGAAA--C-T GAACAACCTG-CTCCTGAA---TG-ACTACTG--GGTACATAACGA--AAT--G-AAGGC AGAAATA---------------AAGATGTTCTTT---GAAAC------------------ ------CAACGAGAACAA-AGA------------CACCAC--ATACCAGAATCTC-TGG- GA-----CGCATTCAAAGCAGTG-----------------------------TGTAGAGG GAAA--TTTATAGCACTA----AATGC----CTACAAGAGAAAGC---AGGAAAGATCC- --AAAATTGAC-ACCCTAA-CATCACAATTA---AAAGAAC--TAGAAAAGC------AA GA-----GCAAACACATT-------------CAAAAGC--TAGCAGAA-GGCAAGAAATA ACT---AAAATCAGA-------------------GCAGAACTG---AA-G-GAAATAGAG ACACA------AA------------------------------------AAA-CCC---T TCAAAAAATC-A---------ATG----AATCCA-GGAGCTG------GTTTTTTGAAAG GATCAA------------------------------------------------------ --------------------------------CAA-----AATTGATAGACCG---CTAG CAA------GACTAA--TAA------------AGAAA------------------AAAAG A---GAGA-AGAATC-----------------AAATAGA--------CACAA-----TA- ---------AAA-AATGATA--AA----------GGGGA---TATCACCACCGATCCC-A CA-GAAATA--CAAACTAC-CATCAG---------AGAATACT--ACAAA---------- -----------CAC---CTCTACGCAAATAA---ACTAGAAAATCTAG---AAGAAAT-- GGATACATTCCT----------CGACACA---------TAC-----ACTCTCCCA----- -AGACTAAACCA---GGAAGAAGTTGAATCTCTGAAT----------------------- AGACC------------AA-TAACAGGCTCTGAAATTGTGG-C---------AATAAT-- -CAATAGTTTACC------AACCAAAAAGAG---TCCAGGACC--AGATGG--------- ------------ATTCACA-GCCG--AA-------------------TTCTA-------- ----CCAGAGGTAC---AAGGAG-GAACTGG--TA-CCATTC----------CTTCTGAA ACTATT----CC---AATCAATAGAA------AAAGAG-GG-----------AATCCTCC CTAACTCATTTT-----ATGAGGCC-----AGCAT---CATTCTG-ATAC---------- ----------------------------------------C--AAAGC-------CGGGC AGA---------------------GAC---ACAACCAAAAA---AGAGAATTTT------ -------------A-GACCAATAT---CCT----TGATGAACATTGAT------------ ------------GCAAAAATCC-TCA--------------------A----TAAAATACT GGC-AAACCG------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTTATCCA--CCATGAT------------C AAG---TGGGC-TT----------CATCCCT------------GG--GATGCAAGGCTGG -T----------------------TC-AAT-----ATACGC--AAATCAATAAA--TGTA ---ATCCAGCATAT------AAACAG----AGCCAAAGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAAGCCTTTGACAA---AATTCAACAACCCTT- ---------------CATGC---------T---A--AA-----AACTCTCAAT---AAAT TAGGTATTGATGGGACGT-----ATTTCAAAATAATAAG--------------------- ------AGCTATCTAT-GACAAA--------CCCACAGC-----------CAATAT--CA TACTGAATGGGCA-----AAA-ACTGGAAGC----ATTC---CCT----TT--GAAAACT GGCACA----AGACAGGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCGCTCCTATTC---AACATAGT GTT---GGAAGTTCTGGCCAGGGCAAT--------CAG-GC------AGGAG---AAGGA --AATAAAGGGTATTCAATTAGGA---AAAGAG------GAAGTCAAA--T--------- ------TGTCCCTG-TT--T---GCAGA------CGACAT------GATTGTTTATCTA- -GAAAACC--CCATCGT---CTCAGCCC---------A---------------AA--ATC TCCTTAAGCT---------GA--TAAGCAACTTCAGCAAAG--TCT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- ACAAAAAT----CACA-------------------------------------------- -----AGCATTCT--TA-TACACCAAC---------------AACAGACAAA-----CAG A------------------GAGCCAAATC-ATG----AGTGAACTCCCATTCACAATTGC TTCA------------------AAGAGAATA---------AAA------TACCTAGGAAT CCAACT--------TA--C-AAGGGATGTG---A---AGGACCTCT---TCAA-GGAGAA CTACAAACCAC------TGCTC-AAGGAAATAA-AA------------GAGG-------- ------------ACAC--AAAC--AAA---TGGA---AG--AACAT---------TCCA- --TGCTC------ATG-GGTAGGAAGAATC-A---A---TATC--------------G-- TGAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--GGTAATTTACA-------------------GA---TTCAATGCC---ATC-- ------C-CCATCAAGCT--A---------------------CCAATG-AC---TTTCTT ------------------------------------------CACAGAATTGG------- ----------------------AAAAAACTAC------TTTAAAG---TTCATATGGAAC C-------AAAAAAGAGCCC---GC--ATCGCCAAGTCAATCCTAAGCC---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACA---CTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---CAAAACAGAGA--- ---TATAGAT--CA---ATGG-AACAGAACAGAGCCCTC------AG---AAATAATG-- -CCGC----------------ATA-------TCTACAA----CTATCT--GATCTTT--- GACAAA--CCTGAGAAAAACAAGC--A-------------------ATGGG--GA---AA GG------------ATTCCCTATT--TAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-CTAGCCA---------------TATGT-AGAAAG---CTG ---------AAACTGGATCCC---TTCCT-----------TACACC--TTA--T---ACA AAAA-TCAATT-CAAGATGG---AT---TAAAGAT---TTAAACGTT--AGACCTAAAAC CAT------------------------AAAAACCCTAGAA---------------GAAAA ---CCTA------G------------------G-CATTACCATTCAGGACATAG--GCG- -----TGGGCAAGGACT-----TCATGTCCAA-AACACCA---AAAGCAATGGCAAC--- --AAAAGCC---AA----AAT---TGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAC-------------CATCAGAGTGAACAG------------------- ------G-------------CAACCT------ACAACA--T-GGGAG---AAAATTTTC- --GCAACCTACTCAT--------CT-------GACAAAGGGC--------TA--ATATC- ---CAGAATCTACAAT-GA--ACTCAA---ACA------AA--TTTAC------------ ---AAG--------------AAAAAAACA---AAC--AACCCCA-TCAA---AAAGTGGG C--GAA---------GGA--CATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATTT---AT-GCAGCCAAA--AAACACATGAAGA AAT----------GCTCATCATCACTG-GCCATCA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACT-------AT---- ----GA---GATATCA---------TCTC----ACACCAGTTAGAATGGCAATCAT---T A--AAAAG-------TCAGGAA-----ACAACA-GGTG--C------------------- ------TGGA-GAGGATGTG----------GAGAA------------------------- ------------ATAGGAACACTTTT-ACACTGTTGG--TGGG----------------- ----------ACTGT--A-------------AACT---AGTTC----AACCATTGTGG-- ------AAGTCAGTG--TGGCG--A-TTCCTC--AGGGATCTAGAA--CTAGAAATACC- -ATTT---GA--CCCAGCCATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAC------------TATAAATCA----T------- --------------GCTGCTAT--AAAGACACATGC---------ACACG----TATGTT TATT--GCGGCACTATTCACAA-TAGCAAAGACTT--G--GA--ACCA--ACCCAA---A TGTCCAACA---ATGATAG-----ACTGGATTAAG--AAAA----TG------------- -----TGGCA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AATGATGAGTTCATGTCCTTT---- ------------------------------------------------------------ --------GTAGGGACATGGATGAAA-T---TGGAAACCATCATTCTCAGTAA------- ------------------------------------------------ACTATCGCAAGA ACAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAACAC-CG-------- ---CAT---ATTCTCACTCAT----------AGGTGGGAATTT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAACA-------ATGAGAT---------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GAA--------GGGGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----ATCACAC-----------------------------------------------T CTG-------GGGACTGTGG----------------TGGGGTCGGGGGAGGGGGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TAGCATTGGGAGATATACCTAATGCTAGAT GACA-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------CGTTAGTGGGTG--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAGCGCACCAGCATGGCA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -CATGTAT-ACATATGT------------------------------------------- --------------------------------------------AACTAA---------- -------------------CCTGCACAATGTGCACATGTACCCTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAACTTAGA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GTATAATAAAAAAAAAAA------------------------------------- ------ >L1PA2 ------------------------------------------------------------ ------------------------------------------------------------ ----------GGGGAGGAGCCAAG-----------------ATGGCCGAATAGGAACAGC TCCGGTCTA---------------------------CAGCTCCCAGCGTG---------- ---------------------------------------AGCGACGCAGAAGACGG---- -----------GTGATTTCTGCATTTCCATCTGAGGTACCGGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------TTCATCTCACTAGG------GAGTGCCAGAC-------AGTGGG CGCAGGTCAGTGGGTGC-GCGCACCGTGCGCGAG---------C-CGAAGCAGGGCGAGG CATTGCCTCACTCG----------GGAAGCG----------------------------- --------------------------------------------------CAAGGGGTCA GGGAGTTCCCTTTCCTAGTCAAAGAAAGGGGTGA-----CG---GACGGCACCTGGAAAA TCGGGTCACTCCCACCCGAATACTGCGCTTTTC-------------------CGACGGGC TTAAAAAACGGCGCACCACGAGATTATATCCCGCACCTG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCTCGGAGGGTCC---------------- -------------------------TACGCCCACGGAGTCTCGCTGATTGCTAGCACAGC AGTCTGAGATCAAACT-------------------------------------------- ------------------------------------------------------------ --GCAAGGCGGCAGCGAGGCTGGGGGAGGGGC-------------GCCCGCCATTGCCCA GGCTTGCTTAGGTAA--------------------------------------------- ---------------------------------------ACAAAGCAGCCGGGAAGCTCG AA-------------------CTGGGTGGAGCCCACCACAG------------------- ------------------------------------------------------------ ----CTCAAGGAGGCC-------------------------------------------- ------------------------------------------------------------ ----------------------------------------TGCCTGCCTCTGTAGGCT-- ---------CCACCTCTGGGGGCAGGGCACAGACAAACAAAAAGACAGCAGTAAC----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CTCTGCAGAC-------TTAAATGTCCCTGTCTGACAGCT TTGAAGAGAGCAGTGGT------------------------------------------- --------------------TCTCCCAGCACGCAG------------------------- --------------------------CTGGAGATCTGAGAACGGGCAGACTGCCTCCTCA AGTGG-GTCCCTGACCCCTGACCCCCGAGCAGCCTAACT--------------------- ------------------------------------------------------------ --------------------------------------------GGGAGGCACCCCCCAG CAG-------GGGCACACTGACACCTCACACGGCAGGGT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ACTCCAACAGA CCTGCAGCTGAGGGTCCTGTCTGTTA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAAGGAAAA-----------CTAACAAACAGAA---- ------------------------------------------------------------ ------------------------------------------------------------ --A-----------GGACATCCACACCAAAAACCCAT----------------------- ----------------------------------------------CTGTACATCACC-- ---------------------------------------ATCATCAAAGAC--------- ---------CAAAA---------------------------------------------- -GTAGATAAAACCACAAAG----------------------------------------- ------------------------------------------------------------ -------------------------------TGGGGAAAAA-----ACAGAACAGAAAAA CTG-------------------------------------GAAACTCTA--------AAA AGCA----GAGCGCCT-------------CTCC--TCCT--CCAA---A-GG-------- -------AAC----GCAGTTCCTC-------------------AC-CAG---CAACGGAA CAAAGCT----GG------ATGGAGA---ATGACTTTGACGAGCTGAGAGAAGA------ ------AGGC------------TTCAGACGAT----------CAAATTACTCTGAGCT-- --ACGGGAGGACATT--------------------------CAAACCAAAGGC-----AA AGAAGTT---------------------------------------------GAAAACTT T-GAAAAAA--------------------------------------------------- -ATTTAGA----------AGAATGTATAACTAGA-------------------------- -------------------------------------------ATAACCAATACAGAGAA ----------GTGC---------------TTAAAGG------AGC---------TGATG- GAGC----TGAAA---------ACCAA---GGCTCGAGAACTACGTGAAGAATGCAGA-- ---AGCCTCAGGAGCCGA----------------TGCG--------------------AT C--AACT------------------GGAAGAAAG-GGT-ATCAG--CGATGGAAGAT--- -GAAATGAATGAAA-T-----GAAGCGAGAAG---------GGAAGTTTAGA---GAAAA AAGA---ATAAAAAGA-AA---------TGA---GCAAAGCCTCC--AAGAAATATGGG- ACTAT--------G---TGAAAAG--ACCAAATCTACGT--C-TGATTGG--TGTA---- ----------CCTGAAAGTGATGGGGAGAATGGA---ACCAAGTTGG---------AAAA CACTCTG---CA-----GGATATTATCCAG--GAGAACTTCCCCAATCT----------- ---------AGCAAGGCAGGC--CAAC--GTTCAGATTC-----AGGAAATACAGAGA-A CGCCACAAA------------GATACTC-CTC--------------GAGAAGAGCAACTC C-------A---------------------AGACACATAATTGTCAGATT------CAC- CAAAGTTGAAA---TGAAGG--AAAAAATGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGTCGGGT-------------- -----------TAC---CCTCAAAGG-GAAGCCCA--------------TCAGACT--AA CAGCGGATCTC-----TCGGCAGAA--ACCCTA-CAAGC------CAG-AAGAGAGTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAATTT--TCA--ACCCAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCAT-AAGTGA-------AG-------- ------------------------G-AGAAATAAAATACTTTACAGACAAGC-AAATGCT GAGAGA-TTTTGTCACCACCAGGC---CTGCCCTAA-AAGAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCGC--------------TAAACA TGG----------------------------------------------------AAAGG AACA---------------ACCGGTA---------------------------------- -------------------------------CCAGCCGCTGCA----------------- ------------------------------------AAATCAT----------------- --------GCCAAAATGGTAAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCATCGAGAC-------------------------TAGGA A-------------------------------------------------GAAACTGCAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CAACTAACGAGCA--------------AA---ATAACCA GCTAA------------------------------------------------------- ------------------------------------------------------------ -------------CATCATA---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCACACATA--ACAATATTAAC-TTTAAAT-------G-T AAAT--GGACT--AAATGC---TCCAATT----------------AAAAGAC------AC AGAC--TGGCAA----ATTG---------GAT-------AAAG---AGTCAAGACCCAT- ---CAG-------TGT-GCTGTATT-CAGGAAACCCATCT-CACGT--GCAGAGACACAC A-TAGGCTCAAAATAAAAGGA---T------------GGAGG----A-AGATCTACCAAG C--------------AAATGG------AAAAC---------------------AAAAA-A AGGCAG--GGGT----TGCAATCCTAGTCTC-TGATAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAGAGAC-AAAG-AAGGCCAT------TACAT------AAT GGTAAA---GGGATCAATT------CAACAA---GAAG--------AG-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAATACAGGAGCAC CCAG--ATT-CATAAAGCAAGTCCTGAGTGACCT--AC----AAAGAGA---------CT TAGACTCCCAC------ACATTAATAATGGGAGACTTTAACA----------------CC CCACT------GTCAAC-ATTAGACAGATCAA---------------------CGAGAC- -----AGAA-------------AGTCAACAAGGATACCCAGGAATTGAAC-TCAGCTCTG CA------CCAAGCGG---ACCTAATAGACATCTACA--GA----ACTCTCCACCCCAAA TC---AACAGAATATACAT------TTTTTTCAGCAC-----CA--CAC-CACACCTATT --C----CAAAATTGACCACATACTTGGAAGTAAAGCTCT-------------------- -CCTCAGCAAATGTAAAAGAA--CAGAAAT----------------TATAACAA------ -ACTATCTCTCA---GACCACAGTGCAA-TCAAACTAGAACTCAGG-------------- ----------------------------------------------ATTA--------AG --------------AAT-CTCACTCA---AAACCGCTCAA----CTACATGGAAA--C-T GAACAACCTG-CTCCTGAA---TG-ACTACTG--GGTACATAACGA--AAT--G-AAGGC AGAAATA---------------AAGATGTTCTTT---GAAAC------------------ ------CAACGAGAACAA-AGA------------CACAAC--ATACCAGAATCTC-TGG- GA-----CGCATTCAAAGCAGTG-----------------------------TGTAGAGG GAAA--TTTATAGCACTA----AATGC----CCACAAGAGAAAGC---AGGAAAGATCC- --AAAATTGAC-ACCCTAA-CATCACAATTA---AAAGAAC--TAGAAAAGC------AA GA-----GCAAACACATT-------------CAAAAGC--TAGCAGAA-GGCAAGAAATA ACT---AAAATCAGA-------------------GCAGAACTG---AA-G-GAAATAGAG ACACA------AA------------------------------------AAA-CCC---T TCAAAAAATT-A---------ATG----AATCCA-GGAGCTG------GTTTTTTGAAAG GATCAA------------------------------------------------------ --------------------------------CAA-----AATTGATAGACCG---CTAG CAA------GACTAA--TAA------------AGAAA------------------AAAAG A---GAGA-AGAATC-----------------AAATAGA--------CACAA-----TA- ---------AAA-AATGATA--AA----------GGGGA---TATCACCACCGATCCC-A CA-GAAATA--CAAACTAC-CATCAG---------AGAATACT--ACAAA---------- -----------CAC---CTCTACGCAAATAA---ACTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------CGACACA---------TAC-----ACTCTCCCA----- -AGACTAAACCA---GGAAGAAGTTGAATCTCTGAAT----------------------- AGACC------------AA-TAACAGGATCTGAAATTGTGG-C---------AATAAT-- -CAATAGCTTACC------AACCAAAAAGAG---TCCAGGACC--AGATGG--------- ------------ATTCACA-GCCG--AA-------------------TTCTA-------- ----CCAGAGGTAC---AAGGAG-GAACTGG--TA-CCATTC----------CTTCTGAA ACTATT----CC---AATCAATAGAA------AAAGAG-GG-----------AATCCTCC CTAACTCATTTT-----ATGAGGCC-----AGCAT---CATTCTG-ATAC---------- ----------------------------------------C--AAAGC-------CGGGC AGA---------------------GAC---ACAACCAAAAA---AGAGAATTTT------ -------------A-GACCAATAT---CCT----TGATGAACATTGAT------------ ------------GCAAAAATCC-TCA--------------------A----TAAAATACT GGC-AAAACG------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTTATCCA--CCATGAT------------C AAG---TGGGC-TT----------CATCCCT------------GG--GATGCAAGGCTGG -T----------------------TC-AAT-----ATACGC--AAATCAATAAA--TGTA ---ATCCAGCATAT------AAACAG----AGCCAAAGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCCTTTGACAA---AATTCAACAACCCTT- ---------------CATGC---------T---A--AA-----AACTCTCAAT---AAAT TAGGTATTGATGGGACGT-----ATTTCAAAATAATAAG--------------------- ------AGCTATCTAT-GACAAA--------CCCACAGC-----------CAATAT--CA TACTGAATGGGCA-----AAA-ACTGGAAGC----ATTC---CCT----TT--GAAAACT GGCACA----AGACAGGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT GTT---GGAAGTTCTGGCCAGGGCAAT--------TAG-GC------AGGAG---AAGGA --AATAAAGGGTATTCAATTAGGA---AAAGAG------GAAGTCAAA--T--------- ------TGTCCCTG-TT--T---GCAGA------TGACAT------GATTGTATATCTA- -GAAAACC--CCATTGT---CTCAGCCC---------A---------------AA--ATC TCCTTAAGCT---------GA--TAAGCAACTTCAGCAAAG--TCT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- ACAAAAAT----CACA-------------------------------------------- -----AGCATTCT--TA-TACACCAAC---------------AACAGACAAA-----CAG A------------------GAGCCAAATC-ATG----AGTGAACTCCCATTCACAATTGC TTCA------------------AAGAGAATA---------AAA------TACCTAGGAAT CCAACT--------TA--C-AAGGGATGTG---A---AGGACCTCT---TCAA-GGAGAA CTACAAACCAC------TGCTC-AAGGAAATAA-AA------------GAGG-------- ------------ATAC--AAAC--AAA---TGGA---AG--AACAT---------TCCA- --TGCTC------ATG-GGTAGGAAGAATC-A---A---TATC--------------G-- TGAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--GGTAATTTACA-------------------GA---TTCAATGCC---ATC-- ------C-CCATCAAGCT--A---------------------CCAATG-CC---TTTCTT ------------------------------------------CACAGAATTGG------- ----------------------AAAAAACTAC------TTTAAAG---TTCATATGGAAC C-------AAAAAAGAGCCC---GC--ATCGCCAAGTCAATCCTAAGCC---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACA---CTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---CAAAACAGAGA--- ---TATAGAT--CA---ATGG-AACAGAACAGAGCCCTC------AG---AAATAACG-- -CCGC----------------ATA-------TCTACAA----CTATCT--GATCTTT--- GACAAA--CCTGAGAAAAACAAGC--A-------------------ATGGG--GA---AA GG------------ATTCCCTATT--TAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-CTAGCCA---------------TATGT-AGAAAG---CTG ---------AAACTGGATCCC---TTCCT-----------TACACC--TTA--T---ACA AAAA-TCAATT-CAAGATGG---AT---TAAAGAC---TTAAACGTT--AGACCTAAAAC CAT------------------------AAAAACCCTAGAA---------------GAAAA ---CCTA------G------------------G-CATTACCATTCAGGACATAG--GCA- -----TGGGCAAGGACT-----TCATGTCTAA-AACACCA---AAAGCAATGGCAAC--- --AAAAGAC---AA----AAT---TGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAC-------------CATCAGAGTGAACAG------------------- ------G-------------CAACCT------ACAAAA--T-GGGAG---AAAATTTTC- --GCAACCTACTCAT--------CT-------GACAAAGGGC--------TA--ATATC- ---CAGAATCTACAAT-GA--ACTCAA---ACA------AA--TTTAC------------ ---AAG--------------AAAAAAACA---AAC--AACCCCA-TCAA---AAAGTGGG C--GAA---------GGA--CATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATTT---AT-GCAGCCAAA--AAACACATGAAAA AAT----------GCTCATCATCACTG-GCCATCA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACACCAGTTAGAATGGCAATCAT---T A--AAAAG-------TCAGGAA-----ACAACA-GGTG--C------------------- ------TGGA-GAGGATGTG----------GAGAA------------------------- ------------ATAGGAACACTTTT-ACACTGTTGG--TGGG----------------- ----------ACTGT--A-------------AACT---AGTTC----AACCATTGTGG-- ------AAGTCAGTG--TGGCG--A-TTCCTC--AGGGATCTAGAA--CTAGAAATACC- -ATTT---GA--CCCAGCCATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAC------------TATAAATCA----T------- --------------GCTGCTAT--AAAGACACATGC---------ACACG----TATGTT TATT--GCGGCATTATTCACAA-TAGCAAAGACTT--G--GA--ACCA--ACCCAA---A TGTCCAACA---ATGATAG-----ACTGGATTAAG--AAAA----TG------------- -----TGGCA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AATGATGAGTTCATGTCCTTT---- ------------------------------------------------------------ --------GTAGGGACATGGATGAAA-T---TGGAAATCATCATTCTCAGTAA------- ------------------------------------------------ACTATCGCAAGA ACAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAACAC-CG-------- ---CAT---ATTCTCACTCAT----------AGGTGGGAATTT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAACA-------ATGAGAT---------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GAA--------GGGGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----ATCACAC-----------------------------------------------T CTG-------GGGACTGTTG----------------TGGGGTGGGGGGAGGGGGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TAGCATTGGGAGATATACCTAATGCTAGAT GACG-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------AGTTAGTGGGTG--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAGCGCACCAGCATGGCA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -CATGTAT-ACATATGT------------------------------------------- --------------------------------------------AACTAA---------- -------------------CCTGCACAATGTGCACATGTACCCTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAACTTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GTA--TAAT AAAAAAAAAAAAAAAAAAAAAAAAAA---------------------------------- ------ >L1PA4 ------------------------------------------------------------ ------------------------------------------------------------ ----------GGGGTGGAGCCAAG-----------------ATGGCCGAATAGGAACAGC TCCAGTCTA---------------------------CAGCTCCCAGCGTG---------- ---------------------------------------AGCGACGCAGAAGACGG---- -----------GTGATTTCTGCATTTCCAACTGAGGTACCGGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------TTCATCTCACTGGG------GAGTGTCGGAC-------AGTGGG TGCAGGACAGTGGGTGCAGCGCACCGAGCGTGAG---------C-CGAAGCAGGGCGAGG CATCGCCTCACCCG----------GGAAGCG----------------------------- --------------------------------------------------CAAGGGGTCA GGGAATTCCCTTTCCTAGTCAAAGAAAGGGGTGA-----CA---GACGGCACCTGGAAAA TCGGGTCACTCCCACCCTAATACTGCGCTTTTC-------------------CAACGGTC TTAGCAAACGGCACACCAGGAGATTATATCCCGCGCCTG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCTCGGAGGGTCC---------------- -------------------------TACGCCCACGGAGCCTCGCTCATTGCTAGCACAGC AGTCTGAGATCAAACT-------------------------------------------- ------------------------------------------------------------ --GCAAGGCGGCAGCGAGGCTGGGGGAGGGGC-------------GCCCGCCATTGCCGA GGCTTGAGTAGGTAA--------------------------------------------- ---------------------------------------ACAAAGCGGCCGGGAAGCTCG AA-------------------CTGGGTGGAGCCCACCGCAG------------------- ------------------------------------------------------------ ----CTCAAGGAGGCC-------------------------------------------- ------------------------------------------------------------ ----------------------------------------TGCCTGCCTCTGTAGACT-- ---------CCACCTCTGGGGGCAGG-GCATAGCCAAACAAAAGGCAGCAGAAAC----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CTCTGCAGAC-------TTAAATGTCCCTGTCTGACAGCT TTGAAGAGAGTAGTGGT------------------------------------------- --------------------TCTCCCAGCACGCAG------------------------- --------------------------CTGGAGATCTGAGAACGGACAGACTGCCTCCTCA AGTGG-GT-------CCCTGACCCCCGAGTAGCCTAACT--------------------- ------------------------------------------------------------ --------------------------------------------GGGAGGCACCCCCCAG TAG-------GGGCAGACTGACACCTCACACGGCCGGGTACTCCTCTGAGACAAAACTTC C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----AGAGGAACG--------------------------------ATCAGGCAGCAACA TT------------TGCTGTTCACCAATATCCGCTGTTCTGCAGCCTCCGCTGC------ ------------------------------------------------------------ ------------------------------------------------------------ ----TGATACCCAGGCAAACAGGGTCTGGAGTGGA----CCTCCAGCAAACTCCAACAGA CCTGCAGCTGAGGGTCCTGACTGTTA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAAGGAAAA-----------CTAACAAACAGAA---- ------------------------------------------------------------ ------------------------------------------------------------ --A-----------GGACATCCACACCAAAACCCCAT----------------------- ----------------------------------------------CTGTACGTCACC-- ---------------------------------------ATCATCAAAGAC--------- ---------CAAAG---------------------------------------------- -GTAGATAAAACCACAAAG----------------------------------------- ------------------------------------------------------------ -------------------------------TGGGGAAAAA-----ACAGAGCAGAAAAA CTG-------------------------------------GAAACTCTA--------AAA ATCA----GAGCGCCT-------------CTCC--TCCT--CCAA---A-GG-------- -------AAC----GCAGCTCCTC-------------------AC-CAG---CAACGGAA CAAAGCT----GG------ACGGAGA---ATGACTTTGACGAGTTGAGAGAAGA------ ------AGGC------------TTCAGACGAT----------CAAACTACTCCGAGCT-- --AAAGGAGGAAGTT--------------------------CGAACCCATGGC-----AA AGAAGTT---------------------------------------------AAAAACCT T-GAAAAAA--------------------------------------------------- -AATTAGA----------CGAATGGCTAACTAGA-------------------------- -------------------------------------------ATAACCAATGCAGAGAA ----------GTCC---------------TTAAAGG------ACC---------TGATG- GAGC----TGAAA---------ACCAA---GGCACGAGAACTACGTGACGAATGCACA-- ---AGCCTCAGTAGCCGA----------------TTCG--------------------AT C--AACT------------------GGAAGAAAG-GGT-ATCAG--TGATGGAAGAT--- -CAAATGAATGAAA-T-----GAAGCGAGAAG---------AGAAGTTTAGA---GAAAA AAGA---ATAAAAAGA-AA---------CGA---ACAAAGCCTCC--AAGAAATATGGG- ACTAT--------G---TGAAAAG--ACCAAATCTACGT--C-TGATTGG--TGTA---- ----------CCTGAAAGTGACGGGGAGAATGGA---ACCAAGTTGG---------AAAA CACTCTG---CA-----GGATATTATCCAG--GAGAACTTCCCCAATCT----------- ---------AGCAAGGCAGGC--CAAC--ATTCAAATTC-----AGGAAATACAGAGA-A CGCCACAAA------------GATACTC-CTC--------------GAGAAGAGCAACTC C-------A---------------------AGACACATAATTGTCAGATT------CAC- CAAAGTTGAAA---TGAAGG--AAAAAATGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGTCGGGT-------------- -----------TAC---CCACAAAGG-GAAGCCCA--------------TCAGACT--AA CAGCTGATCTC-----TCGGCAGAA--ACTCTA-CAAGC------CAG-AAGAGAGTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAATTT--TCA--ACCCAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCAT-AAGTGA-------AG-------- ------------------------G-AGAAATAAAATACTTTACAGACAAGC-AAATGCT GAGAGA-TTTTGTCACCACCAGGC---CTGCCCTAA-AAGAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCAC--------------TAAACA TGG----------------------------------------------------AAAGG AACA---------------ACCGGTA---------------------------------- -------------------------------CCAGCCACTGCA----------------- ------------------------------------AAAACAT----------------- --------GCCAAATTGGTAAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCATCGAGGC-------------------------TAGGA A-------------------------------------------------GAAACTGCAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CAACTAACGAGCA--------------AA---ATAACCA GCTAA------------------------------------------------------- ------------------------------------------------------------ -------------CATCATA---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCACACATA--ACAATATTAAC-CTTAAAT-------G-T AAAT--GGGCT--AAATGC---TCCAATT----------------AAAAGAC------AC AGAC--TGGCAA----ATTG---------GAT-------AAAG---AGTCAAGACCCAT- ---CAG-------TGT-GCTGTATT-CAGGAAACCCATCT-CACGT--GCAGAGACACAC A-TAGGCTCAAAATAAAGGGA---T------------GGAGG----A-AGATCTACCAAG C--------------AAATGG------AAAAC---------------------AAAAA-A AGGCAG--GGGT----TGCAATCCTAGTCTC-TGATAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAGAGAC-AAAG-AAGGCCAT------TACAT------AAT GGTAAA---GGGATCAATT------CAACAA---GAAG--------AG-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAATACAGGAGCAC CCAG--ATT-CATAAAGCAAGTCCTTAGAGACCT--AC----AAAGAGA---------CT TAGACTCCCAC------ACAATAATAATGGGAGACTTTAACA----------------CC CCACT------GTCAAC-ATTAGACAGATCAA---------------------CGAGAC- -----AGAA-------------AGTTAACAAGGATATCCAGGAATTGAAC-TCAGCTCTG CA------CCAAGCGG---ACCTAATAGACATCTACA--GA----ACTCTCCACCCCAAA TC---AACAGAATATACAT------TCTTTTCAGCAC-----CA--CAC-CACACCTATT --C----CAAAATTGACCACATAGTTGGAAGTAAAGCACT-------------------- -CCTCAGCAAATGTAAAAGAA--CAGAAAT----------------TATAACAA------ -ACTGTCTCTCA---GACCACAGTGCAA-TCAAACTAGAACTCAGG-------------- ----------------------------------------------ATTA--------AG --------------AAA-CTCACTCA---AAACCGCTCAA----CTACATGGAAA--C-T GAACAACCTG-CTCCTGAA---TG-ACTACTG--GGTACATAACGA--AAT--G-AAGGC AGAAATA---------------AAGATGTTCTTT---GAAAC------------------ ------CAACGAGAACAA-AGA------------CACAAC--ATACCAGAATCTC-TGG- GA-----CACATTCAAAGCAGTG-----------------------------TGTAGAGG GAAA--TTTATAGCACTA----AATGC----CCACAAGAGAAAGC---AGGAAAGATCT- --AAAATTGAC-ACCCTAA-CATCACAATTA---AAAGAAC--TAGAGAAGC------AA GA-----GCAAACACATT-------------CAAAAGC--TAGCAGAA-GGCAAGAAATA ACT---AAGATCAGA-------------------GCAGAACTG---AA-G-GAAATAGAG ACACA------AA------------------------------------AAA-CCC---T TCAAAAAATC-A---------ATG----AATCCA-GGAGCTG------GTTTTTTGAAAA GATCAA------------------------------------------------------ --------------------------------CAA-----AATTGATAGACCG---CTAG CAA------GACTAA--TAA------------AGAAG------------------AAAAG A---GAGA-AGAATC-----------------AAATAGA--------CGCAA-----TA- ---------AAA-AATGATA--AA----------GGGGA---TATCACCACCGATCCC-A CA-GAAATA--CAAACTAC-CATCAG---------AGAATACT--ATAAA---------- -----------CAC---CTCTACGCAAATAA---ACTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------CGACACA---------TAC-----ACCCTCCCA----- -AGACTAAACCA---GGAAGAAGTTGAATCTCTGAAT----------------------- AGACC------------AA-TAACAGGCTCTGAAATTGAGG-C---------AATAAT-- -TAATAGCTTACC------AACCAAAAAAAG---TCCAGGACC--AGATGG--------- ------------ATTCACA-GCCG--AA-------------------TTCTA-------- ----CCAGAGGTAC---AAGGAG-GAGCTGG--TA-CCATTC----------CTTCTGAA ACTATT----CC---AATCAATAGAA------AAAGAG-GG-----------AATCCTCC CTAACTCATTTT-----ATGAGGCC-----AGCAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAGC-------CTGGC AGA---------------------GAC---ACAACAAAAAA---AGAGAATTTT------ -------------A-GACCAATAT---CCC----TGATGAACATCGAT------------ ------------GCAAAAATCC-TCA--------------------A----TAAAATACT GGC-AAACCG------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTTATCCA--CCATGAT------------C AAG---TGGGC-TT----------CATCCCT------------GG--GATGCAAGGCTGG -T----------------------TC-AAC-----ATACGC--AAATCAATAAA--CGTA ---ATCCAGCATAT------AAACAG----AACCAAAGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCCTTTGACAA---AATTCAACAACCCTT- ---------------CATGC---------T---A--AA-----AACTCTCAAT---AAAT TAGGTATTGATGGGACGT-----ATCTCAAAATAATAAG--------------------- ------AGCTATCTAT-GACAAA--------CCCACAGC-----------CAATAT--CA TACTGAATGGGCA-----AAA-ACTGGAAGC----ATTC---CCT----TT--GAAAACT GGCACA----AGACAGGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT GTT---GGAAGTTCTGGCCAGGGCAAT--------CAG-GC------AGGAG---AAGGA --AATAAAGGGTATTCAATTAGGA---AAAGAG------GAAGTCAAA--T--------- ------TGTCCCTG-TT--T---GCAGA------TGACAT------GATTGTATATCTA- -GAAAACC--CCATCGT---CTCAGCCC---------A---------------AA--ATC TCCTTAAGCT---------GA--TAAGCAACTTCAGCAAAG--TCT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- GCAAAAAT----CACA-------------------------------------------- -----AGCATTCT--TA-TACACCAAT---------------AACAGACAAA-----CAG A------------------GAGCCAAATC-ATG----AGTGAACTCCCATTCACAATTGC TTCA------------------AAGAGAATA---------AAA------TACCTAGGAAT CCAACT--------TA--C-AAGGGATGTG---A---AGGACCTCT---TCAA-GGAGAA CTACAAACCAC------TGCTC-AATGAAATAA-AA------------GAGG-------- ------------ATAC--AAAC--AAA---TGGA---AG--AACAT---------TCCA- --TGCTC------ATG-GGTAGGAAGAATC-A---A---TATC--------------G-- TGAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--GGTAATTTATA-------------------GA---TTCAATGCC---ATC-- ------C-CCATCAAGCT--A---------------------CCAATG-AC---TTTCTT ------------------------------------------CACAGAATTGG------- ----------------------AAAAAACTAC------TTTAAAG---TTCATATGGAAC C-------AAAAAAGAGCCC---GC--ATTGCCAAGTCAATCCTAAGCC---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACG---CTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---CAAAACAGAGA--- ---TATAGAC--CA---ATGG-AACAGAACAGAGCCCTC------AG---AAATAATG-- -CCGC----------------ATA-------TCTACAA----CTATCT--GATCTTT--- GACAAA--CCTGACAAAAACAAGA--A-------------------ATGGG--GA---AA GG------------ATTCCCTATT--TAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-CTAGCCA---------------TATGT-AGAAAG---CTG ---------AAACTGGATCCC---TTCCT-----------TACACC--TTA--T---ACA AAAA-TTAATT-CAAGATGG---AT---TAAAGAC---TTAAATGTT--AGACCTAAAAC CAT------------------------AAAAACCCTAGAA---------------GAAAA ---CCTA------G------------------G-CAATACCATTCAGGACATAG--GCA- -----TGGGCAAGGACT-----TCATGTCTAA-AACACCA---AAAGCAATGGCAAC--- --AAAAGCC---AA----AAT---TGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAC-------------CATCAGAGTGAACAG------------------- ------G-------------CAACCT------ACAGAA--T-GGGAG---AAAATTTTT- --GCAATCTACTCAT--------CT-------GACAAAGGGC--------TA--ATATC- ---CAGAATCTACAAT-GA--ACTCAA---ACA------AA--TTTAC------------ ---AAG--------------AAAAAAACA---AAC--AACCCCA-TCAA---AAAGTGGG C--GAA---------GGA--TATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATTT---AT-GCAGCCAAA--AGACACATGAAAA AAT----------GCTCATCATCACTG-GCCATCA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACACCAGTTAGAATGGCGATCAT---T A--AAAAG-------TCAGGAA-----ACAACA-GGTG--C------------------- ------TGGA-GAGGATGTG----------GAGAA------------------------- ------------ATAGGAACACTTTT-ACACTGTTGG--TGGG----------------- ----------ACTGT--A-------------AACT---AGTTC----AACCATTGTGG-- ------AAGTCAGTG--TGGCG--A-TTCCTC--AGGGATCTAGAA--CTAGAAATACC- -ATTT---GA--CCCAGCCATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAT------------TATAAATCA----T------- --------------GCTGCTAT--AAAGACACATGC---------ACACG----TATGTT TATT--GCGGCACTATTCACAA-TAGCAAAGACTT--G--GA--ACCA--ACCCAA---A TGTCCAACA---ATGATAG-----ACTGGATTAAG--AAAA----TG------------- -----TGGCA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AATGATGAGTTCATGTCCTTT---- ------------------------------------------------------------ --------GTAGGGACATGGATGAAG-C---TGGAAACCATCATTCTCAGCAA------- ------------------------------------------------ACTATCGCAAGG ACAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAACAC-CG-------- ---CAT---GTTCTCACTCAT----------AGGTGGGAATTT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAACA-------ATGAGAA---------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GAA--------GGGGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----ATCACAC-----------------------------------------------A CCG-------GGGCCTGTTG----------------TGGGGTGGGGGGAGGGGGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TAGCATTAGGAGATATACCTAATGTTAAAT GACG-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------AGTTAATGGGTG--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAGCACACCAACATGGCA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -CATGTAT-ACATATGT------------------------------------------- --------------------------------------------AACAAA---------- -------------------CCTGCACGTTGTGCACATGTACCCTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAACTTAAAGTATAATAAAAAAAAAAAAAAAAAAAA--- ------------------------------------------------------------ ----------------------------------TAAAATAAAAAAAAAAAAAATTAAAA TATATTATTATTCTTAAATACAAAATAATAATAAATAAAATATGCAACACCTTATAATAT ATTTGGATTATTCTTTTCTTTTAATAAAATTTCGAAATAAATAGATTTAAGAAAGAGCTA AAATACAATTATTGTAGAGAATTTTTGGAATTTTTAAATAAACATAATTGGAAAAGTATT TTCCAAGTCCTAGATCTATTTATTCTGAAAAAGTTTAGACATTGTGATTCAGTTATAATT TAGACATATACTACAAGGTAAATTGCATTTCTGTTAATACTATATTTTTCTAGG--TATA CAGTTTATAGATAAAAGGGAAAACATTTCAAAATTTAACTCAAACTTGTATAT------- ------ >L1PA5 ------------------------------------------------------------ ------------------------------------------------------------ ----------GGGGCGGTTCCAAG-----------------ATGGCCGAATAGGAACAGC TCCAGTCTA---------------------------CAGCTCCCAGCGTG---------- ---------------------------------------AGCGACGCAGAAGACGG---- -----------GTGATTTCTGCATTTCCAACTGAGGTACCGGG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------TTCATCTCACTGGG------GCTTGTCGGAC-------AGTGGG TGCAGGACAGTGGGTGCAGCCCACCGAGTGTGAG---------C-CGAAGCAGGGCGAGG CATCGCCTCACCCG----------GGAAGCG----------------------------- --------------------------------------------------CAAGGGGTCA GGGAATTCCCTTTCCTAGCCAAGGGAAGCTGTGA-----CA---GATGGCACCTGGAAAA TCGGGTCACTCCCACCCTAATACTGCGCTTTTC-------------------CAATGGTC TTAGCAAACGGCACACCAGGAGATTATATCCCGCGCCTG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCTCGGAGGGTCC---------------- -------------------------CACGCCCACGGAGCCTCGCTCATTGCTAGCACAGC AGTCTGAGATCGAACT-------------------------------------------- ------------------------------------------------------------ --GCAAGGCGGCAGCGAGGCTGGGGGAGGGGC-------------GCCCACCATTGCTGA GGCTTGAGTAGGTAA--------------------------------------------- ---------------------------------------ACAAAGCGGCCAGGAAGCTCG AA-------------------CTGGGTGGAGCCCACCGCAG------------------- ------------------------------------------------------------ ----CTCAAGGAGGCC-------------------------------------------- ------------------------------------------------------------ ----------------------------------------TGCCTGCCTCTGTAGACT-- ---------CCACCTCTGGGGGCAGG-GCATAGCCGAACAAAAGGCAGCAGAAAC----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CTCTGCAGAC-------TTAAATGTCCCTGTCTGACAGCT TTGAAGAGAGTAGTGGT------------------------------------------- --------------------TCTCCCAGCACGGAG------------------------- --------------------------TTTGAGATCTGAGAATGGACAGACTGCCTCCTCA AGTGG-GT-------CCCTGACCCCCGAGTAGCCTAACT--------------------- ------------------------------------------------------------ --------------------------------------------GGGAGGCACCCCCCAG TAG-------GGGCAGACTGACACCTCACACGGCCGGGTACCCCTCTGAGACGAAGCTTC C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----AGAGGAACG--------------------------------ATCAGGCAGCAACA TT------------TGCTGTTCAGCAATATTCGCTGTTCTGCAGCCTCCGCTGC------ ------------------------------------------------------------ ------------------------------------------------------------ ----TGATACCCAGGCAAACAGGGTCTGGAGTGGA----CCTCCAGCAAACTCCAACAGA CCTGCAGCTGAGGGTCCTGACTGTTA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GAAGGAAAA-----------CTAACAAACAGAA---- ------------------------------------------------------------ ------------------------------------------------------------ --A-----------GGACATCCACACCAAAACCCCAT----------------------- ----------------------------------------------CTGTACGTCACC-- ---------------------------------------ATCATCAAAGAC--------- ---------CAAAG---------------------------------------------- -GTAGATAAAACCACAAAG----------------------------------------- ------------------------------------------------------------ -------------------------------TGGGGAAAAA-----ACAGAGCAGAAAAG CTG-------------------------------------AAAATTCTA--------AAA ATCA----GAGCGCCT-------------CTCC--CCCT--CCAA---A-GG-------- -------AAC----GCAGCTCCTC-------------------GC-CAG---CAACGGAA CAAAGCT----GG------ACGGAGA---ATGACTTTGACGAGTTGAGAGAAGA------ ------AGGC------------TTCAGACGAT----------CAAACTTCTCCGAGCT-- --AAAGGAGGAAGTT--------------------------CGAACCCATCGC-----AA AGAAGCT---------------------------------------------AAAAACCT T-GAAAAAA--------------------------------------------------- -GATTAGA----------CGAATGGCTAACTAGA-------------------------- -------------------------------------------ATAACCAGTGTAGAGAA ----------GTCC---------------TTAAATG------ACC---------TGATG- GAGC----TGAAA---------ACCAT---GGCACGAGAACTACGTGACGAATGCACA-- ---AGCTTCAGTAGCCGA----------------TTCG--------------------AT C--AACT------------------GGAAGAAAG-GGT-ATCAG--TGATTGAAGAT--- -CAAATGAATGAAA-T-----GAAGCGAGAAG---------AGAAGTTTAGA---GAAAA AAGA---GTAAAAAGA-AA---------TGA---ACAAAGCCTCC--AAGAAATATGGG- ACTAT--------G---TGAAAAG--ACCAAATCTACGT--C-TGATTGG--TGTA---- ----------CCTGAAAGTGACGGGGAGAATGGA---ACCAAGTTGG---------AAAA CACTCTG---CA-----GGATATTATCCAG--GAGAACTTCCCCAACCT----------- ---------AGCAAGGCAGGC--CAAC--ATTCAAATTC-----AGGAAATACAGAGA-A CGCCACAAA------------GATACTC-CTC--------------GAGAAGAGCAACTC C-------A---------------------AGACACATAATTGTCAGATT------CAC- CAAAGTTGAAA---TGAAGG--AAAAAATGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGTCGGGT-------------- -----------TAC---CCACAAAGG-GAAGCCCA--------------TCAGACT--AA CAGCGGATCTC-----TCGGCAGAA--ACTCTA-CAAGC------CAG-AAGAGAGTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAATTT--TCA--ACCCAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCAT-AAGTGA-------AG-------- ------------------------G-AGAAATAAAATCCTTTACAGACAAGC-AAATGCT GAGAGA-TTTTGTCACCACCAGGC---CTGCCCTAC-AAGAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCAC--------------TAAACA TGG----------------------------------------------------AAAGG AACA---------------ACCGGTA---------------------------------- -------------------------------CCAGCCACTGCA----------------- ------------------------------------AAAACAT----------------- --------GCCAAATTGGTAAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCATCGATGC-------------------------TAGGA A-------------------------------------------------GAAACTGCAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CAACTAACGAGCA--------------AA---ATAACCA GCTAA------------------------------------------------------- ------------------------------------------------------------ -------------CATCATA---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCACACATA--ACAATATTAAC-CTTAAAT-------G-T AAAT--GGGCT--AAATGC---TCCAATT----------------AAAAGAC------AC AGAC--TGGCAA----ATTG---------GAT-------AAAG---AGTCAAGACCCAT- ---CAG-------TGT-GCTGTATT-CAGGAGACCCATCT-CACGT--GCAGAGACACAC A-TAGGCTCAAAATAAAGGGA---T------------GGAGG----A-AGATCTACCAAG C--------------AAATGG------AAAAC---------------------AAAAA-A AGGCAG--GGGT----TGCAATCCTAGTCTC-TGATAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAGAGAC-AAAG-AAGGCCAT------TACAT------AAT GGTAAA---GGGATCAATT------CAACAA---GAAG--------AG-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAATACAGGAGCAC CCAG--ATT-CATAAAGCAAGTCCTTAGAGACCT--AC----AAAGAGA---------CT TAGACTCCCAC------ACAATAATAATGGGAGACTTTAACA----------------CC CCACT------GTCAAC-ATTAGACAGATCAA---------------------CGAGAC- -----AGAA-------------AGTTAACAAGGATATCCAGGAATTGAAC-TCAGCTCTG CA------CCAAGCGG---ACCTAATAGACATCTACA--GA----ACTCTCCACCCCAAA TC---AACAGAATATACAT------TCTTCTCAGCAC-----CA--CAT-CGCACTTATT --C----CAAAATTGACCACATAGTTGGAAGTAAAGCACT-------------------- -CCTCAGCAAATGTAAAAGAA--CAGAAAT----------------TATAACAA------ -ACTGTCTCTCA---GACCACAGTGCAA-TCAAACTAGAACTCAGG-------------- ----------------------------------------------ATTA--------AG --------------AAA-CTCACTCA---AAACCGCTCAA----CTACATGGAAA--C-T GAACAACCTG-CTCCTGAA---TG-ACTACTG--GGTACATAACGA--AAT--G-AAGGC AGAAATA---------------AAGATGTTCTTT---GAAAC------------------ ------CAATGAGAACAA-AGA------------CACAAC--ATACCAGAATCTC-TGG- GA-----CACATTTAAAGCAGTG-----------------------------TGTAGAGG GAAA--TTTATAGCACTA----AATGC----CCACAAGAGAAAGC---AGGAAAGATCT- --AAAATTGAC-ACCCTAA-CATCACAATTA---AAAGAAC--TAGAGAAGC------AA GA-----GCAAACACATT-------------CAAAAGC--TAGCAGAA-GGCAAGAAATA ACT---AAGATCAGA-------------------GCAGAACTG---AA-G-GAGATAGAG ACACA------AA------------------------------------AAA-CCC---T TCAAAAAATC-A---------ATG----AATCCA-GGAGCTG------GTTTTTTGAAAA GATCAA------------------------------------------------------ --------------------------------CAA-----AATTGATAGACCG---CTAG CAA------GACTAA--TAA------------AGAAG------------------AAAAG A---GAGA-AGAATC-----------------AAATAGA--------CGCAA-----TA- ---------AAA-AATGATA--AA----------GGGGA---TATCACCACCGATCCC-A CA-GAAATA--CAAACTAC-CATCAG---------AGAATACT--ATAAA---------- -----------CAC---CTCTACGCAAATAA---ACTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----ACCCTCCCA----- -AGACTAAACCA---GGAAGAAGTTGAATCCCTGAAT----------------------- AGACC------------AA-TAACAGGCTCTGAAATTGAGG-C---------AATAAT-- -TAATAGCCTACC------AACCAAAAAAAG---TCCAGGACC--AGACGG--------- ------------ATTCACA-GCCG--AA-------------------TTCTA-------- ----CCAGAGGTAC---AAGGAG-GAGCTGG--TA-CCATTC----------CTTCTGAA ACTATT----CC---AATCAATAGAA------AAAGAG-GG-----------AATCCTCC CTAACTCATTTT-----ATGAGGCC-----AGCAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAGC-------CTGGC AGA---------------------GAC---ACAACAAAAAA---AGAGAATTTT------ -------------A-GACCAATAT---CCC----TGATGAACATCGAT------------ ------------GCAAAAATCC-TCA--------------------A----TAAAATACT GGC-AAACCG------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTTATCCA--CCATGAT------------C AAG---TGGGC-TT----------CATCCCT------------GG--GATGCAAGGCTGG -T----------------------TC-AAC-----ATACGC--AAATCAATAAA--CGTA ---ATCCAGCATAT------AAACAG----AACCAAAGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCCTTTGACAA---AATTCAACAGCCCTT- ---------------CATGC---------T---A--AA-----AACTCTCAAT---AAAT TAGGTATTGATGGGACGT-----ATCTCAAAATAATAAG--------------------- ------AGCTATTTAT-GACAAA--------CCCACAGC-----------CAATAT--CA TACTGAATGGGCA-----AAA-ACTGGAAGC----ATTC---CCT----TT--GAAAACT GGCACA----AGACAGGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT GTT---GGAAGTTCTGGCCAGGGCAAT--------CAG-GC------AGGAG---AAAGA --AATAAAGGGTATTCAATTAGGA---AAAGAG------GAAGTCAAA--T--------- ------TGTCCCTG-TT--T---GCAGA------TGACAT------GATTGTATATTTA- -GAAAACC--CCATCGT---CTCAGCCC---------A---------------AA--ATC TCCTTAAGCT---------GA--TAAGCAACTTCAGCAAAG--TCT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- GCAAAAAT----CACA-------------------------------------------- -----AGCATTCT--TA-TACACCAAT---------------AACAGACAAA-----CAG A------------------GAGCCAAATC-ATG----AGTGAACTCCCATTCACAATTGC TTCA------------------AAGAGAATA---------AAA------TACCTAGGAAT CCAACT--------TA--C-AAGGGATGTG---A---AGGACCTCT---TCAA-GGAGAA CTACAAACCAC------TGCTC-AACGAAATAA-AA------------GAGG-------- ------------ACAC--AAAC--AAA---TGGA---AG--AACAT---------TCCA- --TGCTC------ATG-GATAGGAAGAATC-A---A---TATC--------------G-- TGAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--GGTAATTTATA-------------------GA---TTCAATGCC---ATC-- ------C-CCATCAAGCT--A---------------------CCAATG-AC---TTTCTT ------------------------------------------CACAGAATTGG------- ----------------------AAAAAACTAC------TTTAAAG---TTCATATGGAAC C-------AAAAAAGAGCCC---GC--ATTGCCAAGACAATCCTAAGCC---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACG---CTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---CAAAACAGAGA--- ---TATAGAC--CA---ATGG-AACAGAACAGAGCCCTC------AG---AAATAATA-- -CCAC----------------ACA-------TCTACAA----CCATCT--GATCTTT--- GACAAA--CCTGACAAAAACAAGA--A-------------------ATGGG--GA---AA GG------------ATTCCCTATT--TAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-CTAGCCA---------------TATGT-AGAAAG---CTG ---------AAACTGGATCCC---TTCCT-----------TACACC--TTA--T---ACA AAAA-TTAATT-CAAGATGG---AT---TAAAGAC---TTAAATGTT--AGACCTAAAAC CAT------------------------AAAAACCCTAGAA---------------GAAAA ---CCTA------G------------------G-CAATACCATTCAGGACATAG--GCA- -----TGGGCAAGGACT-----TCATGTCTAA-AACACCA---AAAGCAATGGCAAC--- --AAAAGCC---AA----AAT---TGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAC-------------CATCAGAGTGAACAG------------------- ------G-------------CAACCT------ACAGAA--T-GGGAG---AAAATTTTT- --GCAATCTACTCAT--------CT-------GACAAAGGGC--------TA--ATATC- ---CAGAATCTACAAA-GA--ACTCAA---ACA------AA--TTTAC------------ ---AAG--------------AAAAAAACA---AAC--AACCCCA-TCAA---AAAGTGGG C--GAA---------GGA--TATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATTT---AT-GCAGCCAAC--AGACACATGAAAA AAT----------GCTCATCATCACTG-GCCATCA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACACCAGTTAGAATGGCGATCAT---T A--AAAAG-------TCAGGAA-----ACAACA-GGTG--C------------------- ------TGGA-GAGGATGTG----------GAGAA------------------------- ------------ATAGGAACACTTTT-ACACTGTTGG--TGGG----------------- ----------ACTGT--A-------------AACT---AGTTC----AACCATTGTGG-- ------AAGACAGTG--TGGCG--A-TTCCTC--AAGGATCTAGAA--CTAGAAATACC- -ATTT---GA--CCCAGCCATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAT------------TATAAATCA----T------- --------------GCTGCTAT--AAAGACACATGC---------ACACG----TATGTT TATT--GCGGCACTATTCACAA-TAGCAAAGACTT--G--GA--ACCA--ACCCAA---A TGTCCATCA---ATGATAG-----ACTGGATTAAG--AAAA----TG------------- -----TGGCA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AAGGATGAGTTCATGTCCTTT---- ------------------------------------------------------------ --------GTAGGGACATGGATGAAG-C---TGGAAACCATCATTCTCAGCAA------- ------------------------------------------------ACTATCGCAAGG ACAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAACAC-CG-------- ---CAT---GTTCTCACTCAT----------AGGTGGGAATTT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAACA-------ATGAGAA---------------CACT---------- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GAA--------GGGGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----ATCACAC-----------------------------------------------A CCG-------GGGCCTGTCG----------------TGGGGTGGGGGGAGGGGGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TAGCATTAGGAGATATACCTAATGTAAATG ACG--------------------------------------------------------- ------------------------------------------------------------ ---------------------------------AGTTAATGGGTG--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAGCACACCAACATGGCA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -CATGTAT-ACATATGT------------------------------------------- --------------------------------------------AACAAA---------- -------------------CCTGCACGTTGTGCACATGTACCCTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAACTTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GTATAATAAAAAAAAAAA------------------------------------- ------ >L1PA8A ------------------------------------------------------------ ------------------------------------------------------------ ----------GGGGCGGGGCCAAG-----------------ATGGCCGACTAGAAGCAGC GGCGTTCGG---------------------------AGGCTCCCATCGAAA--------- ---------------------------------------AAAAACATAATAAGCGT---- -----------GTGAATCCTTCACCGGCAACCAAGGTATCCAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------GTTCTCTCATCAAA------ATTGACTAGAA------------- --------GGCTGGCGTGACCCACGGAGAGAAGG-----------AAGAGCAGTGTGGTG CGGTGGCCCACCTG---------------------------------------------- ------------------------------------------AGAGCCACACGGGGAAGG GGAACCCCCTCCCCCCAGCCAAGGGAGGCGGTGAGTGAGCGTGCTACCCAGCCGGGGAAA CTGTGCTTTTTC----------------------------------------CACGGAAC TGTGCAACCCACGGATCGGAAGATCCCACTCGCGAACCCACGCCACCGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GGCCTAGCGTCCCAACCCCGGAACGCGCA GATTCTTACAGCCTCTCAGCTGGAATCTGCTTAAGCCTACCGAACTCCCGGGGGGAGGGG CGACCAGCACCAGCTG-------------------------------------------- -----------------------------------------------CGGCTGCCTGCTG TCTAAGCCATTTGAGCTCCTTGGGGGAGGGGC-------------AGCAGCCAGCACTGG GACTCGCAACTGCCTAACACGCTAAGCTCCCTGGGCGGGGGAAGGGCGGCACCCATTTCT ATAGCTCCAGGCTGTGCTTTTCCCCTGCTGGAG------CCAGGGAGGCTGGACGGCTTG GT-------------------CCCAAGACTTGTCCCCACAG------------------- ------------------------------------------------------------ ----CCCAACACACCGGCTGTGGCAGTCTGCGGCC------------------------- ------------------------------------------------------------ ----------------------------------------AGAGTGCCTCTTCAGGCCTA ACCCTGACCCATCCTTCCTCAGTGGGCGGGGCTTCCCTGCAGGATCTCCAATAACTCCAG CCAGAGGCTCAGGGACAGAATTCGGATCTCCCTGGGCCTGAGCCCCTAGGGGGAGGGGTG GCCGCAGT---------------------------------------------------- ------------------------------------------------------------ --------------------CTCTGTGGACCAGCAGACTTAGCCTCTCCTCCTGGTAGTT CTGAGGAATCCGGGCAGCCCAGACGAGT-------------------------------- ------------------------------------------------------------ -----GGGTTTCCCCCCAGCGAAACACACCCTCTCCACCAAGGGACAAAGTGCTTCGTTA AATGG---------GTCCTGCTCCCCGTGCCACCCAACT--------------------- ------------------------------------------------------------ --------------------------------------------GGGTGAGACCCTCCAA CAG-------GGGTTGTCAGACACCCTATACAGGAGCGATCCTACTGGCATCAGGTTGGT G----------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------CCCCTCGAGGTCAGAG GTCCCAGAAGAAGG--------------------------------AGCAGGCACCCATC TT------------TGCTGCTCTCCAGCCTCCTTGAGTGACATCTCCAGGCACGGG---- ------------------------------------------------------------ ------------------------------------------------------------ ----AGCGAATCAGATGAATAGGGCCTGAAGTGAA----CCCCCAGCAAACTGCAGCAGC CCTACAGAAGAGGGACCTGACTATTG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AAAGAAAAA-----------CAAACAAGCAGAAAG-- ------------------------------------------------------------ ------------------TGACAACAACAGCATCAACAACAACAACA------------- --A-----------CAACAACAAAAAGGCCCCCACAAAAACCCCAT-------------- ----------------------------------------------CCAAGGGTCAGC-- ---------------------------------------AGCCTCAAAGAC--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------CGAAACTAGA-----CAAACTCACG---- ----------------------------------------AAGACCCAA--------AAG GCCA----GAGTGCCT-------------CTTC--TCCT--CCAA---A-TG-------- -------ATC----GCAACGTCTC-------------------TC-CAT---CAAGGGCG CAGAACT----------GGACGGAGG---ATCAGATGGACGAATTGACAGAAGT------ ------AGGC------------TTCAGAAGATGGGT-AATAAAAAACTACGATGAGCT-- --AAAGGAGCATGTT--------------------------CTAACCCAATGC-----AA AGAAGCT---------------------------------------------AAGAACCT T-GATAAAA--------------------------------------------------- -GGTTAGA----------GGAATTGCTAACTAGA-------------------------- -------------------------------------------ATAACCAGTTTAGAGAG ----------GAAC---------------ATAAACG------ACC---------TGATG- GAGC----TGAAA---------AACAC---AGCACGAGAACTTCGTGAAGCATACACA-- ---AGTATCAACAGCCGA----------------ATCG--------------------AC C--AAGC------------------AGAAGAAAG-GAT-ATCAG--AGTTTGAAGAC--- -CACCTTACTGAAA-T-----AAGACATGCAG---------ACAAGAATAGA---GAAAA AAGA---ATGAAAAGG-AA---------TGA---ACAAAGCCTCC--AAGAAATATGGG- ACTTC--------A---TAAAAAG--ACCGAACCTACGA--T-TGATTGG--AGTA---- ----------CCAGAAGGAGATGGGGAGAATGGA---AACAAGCTGG---------AAAA CACACTT---CA-----GGATATTATCCAG--GAGAACTTCCCCAACCT----------- ---------AGCAAGACAGGC--CAAC--ATGCAAATTC-----AGGAAATACAGAGA-A CACCATTAA------------GATACTC-CAC--------------GAGAAGATCAACCC C-------A---------------------AGACACATAATCATCAGATT------CTC- CAAGGTCGAAA---TGAAGG--AAAAACTGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGCCAGGT-------------- -----------CAC---CTACAAAGG-GAAGCCCA--------------TCAGACT--AA CAGCAGACCTC-----TCAGCAGAA--ACTCTA-CAAGC------CAG-AAGAGATTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAATTT--TCA--ACCCAGAA--------TTT---CATAT CCA-----------GCCAAACTAAGC-----TTCAT-AAGCGA-------AG-------- ------------------------G-AGAAATAAAATCCTTTCCAGACAAGC-AAATGCT GAGGGA-TTTCGTTACCACCAGGC---CTGCCCTGC-AAGAG------------------ --------------------CTCCTGAAAGA----------------------------- -----------------------------------AGCAC--------------TAAATA TGG----------------------------------------------------AAAGG AAAA---------------ACCGGTA---------------------------------- -------------------------------CCAGCCACTGCA----------------- ------------------------------------AAAACAC----------------- --------ACCAAAATAATAAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCAATGACAC-------------------------TATGA A-------------------------------------------------GAAACTGCAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CAACTAGTGTGCA--------------AA---ATAACCA AATAG------------------------------------------------------- ------------------------------------------------------------ -------------CATCATG---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCACACATA--ACAATACTAAC-CTTAAAT-------G-T AAAT--GGGCT--AAATGC---CCCAATT----------------AAAAGAC------AC AGAC--TGGCAA----ATTG---------GAT-------AAGG---AGTCAAGACCCAT- ---CAG-------TGT-GCTGTATT-CAGGAGACCCATCT-TACAT--GCAAAGACACAC A-CAGGCTCAAAATAAAGGGA---T------------GGAGG----A-AAATTTACCAAG C--------------AAATGG------AAAGCAAAAAAAAAAAAAA-------AAAAAAA AAACAG--GGGT----TGCAATCCTAGTCTC-TGACAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAAAGAC-AAAG-AAGGGCAT------TACAT------AAT GGTAAA---GGGAACAATT------CAACAA---GAAG--------AG-CTAACTA-TTC TAA-----------------A----TATATATG---------CACCCAATACAGGAGCAC CCAG--ATT-CATAAAACAAGTTCTTAGAGACCT--AC----AAAGAGA---------CT TAGACTCCCAC------ACAATAATAGTGGGAGACTTTAACA----------------CC CCACT------GTCAAT-ATTAGACAGATCAA---------------------CGAGAC- -----AGAA-------------AATTAACAAGGATATTCAGGACTTGAAC-TCAGCTCTG GA------TCAAGTGG---ACCTAGTAGACGTCTACA--GA----ACTCTCTACCCCAAA TC---AACAGAATATACAT------TCTTCTCAGTGC-----CA--CAT-GGCACTTATT --C----TAAAATCGACCACATAATTGGAAGTAAAACACT-------------------- -CCTCAGCAAATGCAAAAGAA--CTGAAAT----------------CATAACAA------ -ACAGTCTCTCA---GACCACAGTGCAA-TCAAATTAGAACTCAGG-------------- ----------------------------------------------ATTA--------AG --------------AAA-CTCACTCA---AAACCACACAA----TTTCATGGAAA--T-T GAACAACCTG-CTCCTGAA---TG-ACTCCTG--GGTAAATAATGA--AAT--T-AAGGC AGAAATC---------------AAGAAGTTCTTT---GAAAC------------------ ------CAATGAGAACAA-AGA------------GACAAC--GTACCAGAATCTC-TGG- GA-----CACAGCTAAAGCAGTG-----------------------------TTAAGAGG GAAA--TTTATAGCACTA----AATGC----CCACATCAGAAAGC---TAGAAAGATCT- --CAAATCGAC-ACCCTAA-CATCACAATTA---AAAGAGC--TAGAGAGGC------AA GA-----GCAAACTAATC-------------CAAAAGC--TAGCAGAA-GACAAGAAATA ACT---AAGATCAGA-------------------GAAGAATTG---AA-G-GAGATAGAG ACACG------AA------------------------------------AAA-CCC---T CCAAAAAATC-A---------ATG----AATCCA-GGAGCTG------GTTTTTTGAAAA AATTAA------------------------------------------------------ --------------------------------CAA-----AATAGATAGACCG---CTAG CTA------GACTAA--TAA------------AGAAG------------------AAGAG A---GAGA-AGAATC-----------------AAATAGA--------CACAA-----TA- ---------AAA-AATGATA--AA----------GGGGA---TATCACCACTGACCCC-A CA-GAAATA--CAAACTAC-CATCAG---------AGAATACT--ATAAA---------- -----------CAC---CTCTACGCAAATAA---ACTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----ACCCTCCCA----- -AGACTAAACCA---GGAAGAAGTTGAATCCCTGAAT----------------------- AGACC------------AA-TAACAAGCTCTGAAATTGAGG-C---------AGTAAT-- -TAATAGCCTACC------AACCAAAAAAAG---CCCAGGACC--AGACGG--------- ------------ATTCACA-GCTG--AA-------------------TTCTA-------- ----CCAGAAATAC---AAAGAG-GAGCTGG--TA-CCATTC----------CTTCTGAA ACTATT----CC---AAACAATTGAA------AAGGAG-GG-----------ACTCCTCC CTAACTCATTTT-----ATGAAGCC-----AGCAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGGA AGA---------------------GAC---ACAACAAAAAA---AGAAAACTTC------ -------------A-GGCCAATAT---CCC----TGATGAACATCGAT------------ ------------GCGAAAATCC-TCA--------------------A----TAAAATACT GGC-AAACCG------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAACTTATCCA--CCACGAT------------C AAG---TCGGC-TT----------CATCCCT------------GG--GATGCAAGGCTGG -T----------------------TC-AAC-----ATACGC--AAATCAATAAA--CGTA ---ATCCATCACAT------AAACAG----AACCAAAGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCCTTTGATAA---AATTCAACATCCCTT- ---------------CATGT---------T---A--AA-----AACTCTCAAT---AAAC TAGGTATTGATGGAACAT-----ATCTCAAAATAATAAG--------------------- ------AGCTATTTAT-GACAAA--------CCCACAGC-----------CAATAT--CA TACTGAATGGGCA-----AAA-GCTGGAAGC----ATTC---CCT----TT--GAAAACT GGTACA----AGACAAGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ATT---GGAAGTTCTGGCCAGGGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAGGGTATTCAAATAGGA---AGAGAG------GAAGTCAAG--T--------- ------TGTCTCTG-TT--T---GCAGA------TGACAT------GATTTTATATTTA- -GAAAACC--CCATCAT---CTCAGCCC---------A---------------AA--AAC TCCTTGAACT---------GA--TAAGCAACTTCAGCAAAG--TCT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- GCAAAAAT----CACA-------------------------------------------- -----AGCATTCC--TT-TACACCAAC---------------AATAGGCAAG-----CAG A------------------GAGCCAAATC-ATG----AATGAACTCCCATTCACAATTGC TACA------------------AAGAGAATA---------AAA------TACCTAGGAAT ACAGCT--------AA--C-AAGGGATGTG---A---AGGACCTCT---TCAA-GGAGAA CTACAAACCAC------TGCTC-AAGGAAATAA-GA------------GAGG-------- ------------ACAC--AAAC--AAA---TGGA---AA--AACAT---------TCCA- --TCCTC------ATG-GATAGGAAGAATC-A---A---TATC--------------G-- TGAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--AGTAATTTATA-------------------GA---TTCAATGCT---ATT-- ------C-CCATCAAACT--A---------------------CCATTG-AC---ATTCTT ------------------------------------------CACAGAATTAG------- ----------------------AAAAAACTAT------TTTAAAT---TTCATATGGAAT C-------AAAGAAGACCCC---GT--ATAGCCAAGACAATCCTAAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCATG---CTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---CAAAACAGACA--- ---TATAGAC--CA---ATGG-AGCAGAACAGAGACCTC------AG---AAATAACA-- -CCAC----------------ACA-------TCTACAA----CCATCT--GATCTTC--- AACAAA--CCTGACAAAAACAAGC--A-------------------ATGGG--GA---AA GG------------ATCTCCTATT--CAGTAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-CTAGCCA---------------TATGC-AGAAAA---CTG ---------AAACTGGACCCC---TTCCT-----------TACACC--TTA--T---ACA AAAA-TTAACT-CAAGATGG---AT---TAAAGAC---TTAAATGTA--AAACCCAAAAC CAT------------------------AAAAACCCTAGAA---------------GAAAA ---CCTA-------------------------GGCAATACCATTCAGGACATAG--GCA- -----TGGGCAAAGACT-----TCATGACAAA-AACGCCA---AAAGCAATTGCAAC--- --AAAAGCC---AA----AAT---TGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAT-------------CATCAGAGTGAACAG------------------- ------G-------------CAACCT------ACAGAA--T-GGGAG---AAAATTTTT- --GCAATCTACCCAT--------CT-------GACAAAGGTC--------TA--ATATC- ---CAGAATTTACAAG-GA--ACTTAA---ACA------TA--TTTAC------------ --------------------AAGAAAAAA---AAC--AACCCCA-TCAA---AAAGTGGG C--AAA---------GGA--TATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATTT---AT-GTGGCCAAC--AAACATATGAAAA AAA----------GCTCAACATCACTG-ATCATCA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACGCCAGTCAGAATGGCGATTAT---T A--AAAAG-------TCAGGAA-----ACAATA-GATG--C------------------- ------TGGC-GAGGCTGTG----------GAGAA------------------------- ------------ATAGGAACGCTTTT-ACACTGTTGG--TGGG----------------- ----------AATGT--A-------------AATT---AGTTC----AACCATTGTGG-- ------AAGACAGTA--TGGCG--A-TTCCTC--AAGGATCTAGAA--CCAGAAATACC- -ATTT---GA--CCCAGCAATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAA------------TATAAATCA----T------- --------------TCTACTAT--AAAGACACATGC---------ACACG----TATGTT TATT--GCAGCACTATTTACAA-TAGCAAAGACAT--G--GA--ACCA--ACCCAA---A TGCCCATCA---ATGATAG-----ACTGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AGGAATGAGATCATGTCCTTT---- ------------------------------------------------------------ --------GCAGGGACATGGATGAAG-C---TGGAAGCCATCATCCTCAGCAA------- ------------------------------------------------ACTAACACAGGA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAACAC-CG-------- ---CAT---GTTCTCACTCAT----------AAGTGGGAGTTT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAACA-------TTGAGAA---------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GGGGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AACACAC-----------------------------------------------A CCA-------GGGCCTGTTG----------------GGGGGTGGGGGGTGAGGGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ACTTAGAGGATG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------GGTCAATAGGTG--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------CAGCAAACCACCATGGCA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -CACGTAT-ACCTATGT------------------------------------------- --------------------------------------------AACAAA---------- -------------------CCTGCACGTTCTGCACATGTATCCCG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CTTTTTTTGTTTTTTTTTTTT TTTTTTTAGAAGAAATAAAGAAAAA----------------------------------- ------ >L1PA10 ------------------------------------------------------------ ------------------------------------------------------------ -----------GGGAGGGGCCAAG-----------------ATGGCCGACTAGAAACAGC TGCAGTCGG---------------------------AGGCTCCCACCGAG---------- ---------------------------------------AAGAACGAAAACGGCGA---- -----------GTGAATCCTGCACCGGCAACTGAGGTATCCAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------GTTCTCTCACTGGG------ACTGACTAGGC------------- --------GGTTGGCGCGACCCACGGAGAGCGAG---------G-AAAAGCAGGGTGGAG CGACGGCCCACCTG---------------------------------------------- ------------------------------------------GGAGCCACACGGGGCAAG GGGAGCTCCCACCCCCAGCCAAGGGAGGCAGTGA-----GT---GATTGTGCTACCCTGC CCGGGAAACCACGCTTTTTC--------------------------------CATGGATC TGTGCAACCCGCGGATCAGGAGATCCCCCTCGTGAGCCCACGCCACCAG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GGCCTTGGGTCCC---------AAGCACA GAGCTGTGCAGATTCTCAGCGGCCACTCGGCTGGAGACTGCCTAAGACTACCGAGTTCCC GGGGGGAGGGGCGGCC-------------------------------------------- --------------------------------------ATCATCACTGTGGCTGCCTGCT GCCTAAGATGACTGAGTTCCTGGGGGGAGGGGT------------GGCAGCCATCACTGC AGCTCCAGTCTGCTGTTTTTCCCCTGCCGGTG---------------------------- ---------------------------------------CTGGGGAGACTGGGTGGTTTG GA-------------------CCAGGAGGAATTCCCCACAG------------------- ------------------------------------------------------------ ----TGCAGCACAGCGGCTGTGGCAGATCGTGGCC------------------------- ------------------------------------------------------------ ----------------------------------------AGACTGCCTCTTTAGGCTGG ACCCTGACCCATCCCTCCTCACTGGGCGGGGCCTCCCTGCAGGAATTTCAGCAACTCCAG CCAGGGGTTTAGGGACAGAACTCTGATCTCCCTGGGACTGAGCCCCTGGGGGGAGGGGTG GCCGCGGTCTCCACGGATCAGCAGACTTAGTCTTTCCC---------------------- ------------------------------------------------------------ --------------------CCTGCTGGCT-------CTGAGGAATCCGGGCAGTCCAGA TGAGTGGGATT------------------------------------------------- --------------------CCCCCCAGCGCAGCG------------------------- ----------------------CACCCCCTCTGCCAAGGGGCAGCCAGAGTGCTTCGTTA AGCGG-GTCCCTGATCCCGTGCCTCCTGACT----------------------------- ------------------------------------------------------------ --------------------------------------------GGGTGAGACCCCCCAA CAG-------GGGTCGCCAGACACCTTATACAGGAGCATTCCCGCTGGCATCAGGTCGGT G----------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------CCCCTCTGGGACGGAG CTCCCAGAGGAAGG--------------------------------AGCAGGCAGCCATC TT------------TGCTGTTCTGCAGCCTCCACTGGTGACACCTCCAGGTGCGGG---- ------------------------------------------------------------ ------------------------------------------------------------ ----AGGGACCCAGGCGAATAGGGTCTGGAGTGGA----CCCCCAGCAAACCGCAGCAGC CCTACGGAAGAGGGGCCTGACTGTTA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AAAGAAAAA-----------CAAACAAACAGAAAGCA ------------------------------------------------------------ ------------------------------------------------------------ --A-----------CAACAACAGCATCAACAAAAAAGGCCCCCCAAAAACCCCAT----- ----------------------------------------------CCAAAGGTCAGC-- ---------------------------------------AGCCTCAAAGAT--------- ---------CAAAG---------------------------------------------- -CTAGATAAACTCATGAAG----------------------------------------- ------------------------------------------------------------ -------------------------------TGAGAAAAAA-----TCAATGCAAAAATG CTG-------------------------------------AAAACTCAA--------AAA GCCA----GAGTGCCT-------------CTTC--TCCT--CCAA---A-TG-------- -------ATT----GCAACACCTC-------------------TC-CAG---CAAGGGCA CAGAACT----------GGGCTGAGG---CTGAGATGGATGAATTGACAGAAGT------ ------AGGC------------TTCAGAAGGTGGGT-AATAATGAACTTCGCTGAGCT-- --AAAGGAGCATGTT--------------------------CTAACCCAATGC-----AA AGAAGCT---------------------------------------------AAGAACCA T-GATAAAA--------------------------------------------------- -CATTACA----------GGAGCTGTTAACCAGA-------------------------- -------------------------------------------ATAACCAGTTTAGAGAG ----------GAAC---------------ATAAATG------ACC---------TGATG- GAGC----TGAAA---------AACAC---AACACGAGAACTTCACAATGCAACCACA-- ---AGTATCAATAGCCAA----------------ATAG--------------------AC C--AAGC------------------AGAGGAAAG-AAT-TTCAG--AGCTTGAAGAC--- -TATCTTGCTGAAA-T-----AAGACAGGCAG---------ACAAGATTAGA---GAAAA AAGA---ATGAAAAGG-AA---------TGA---ACAAAACCTCC--AAGAACTATGGG- ATTAT--------G---TAAAAAG--ACCAAACCTACGA--C-TGATTGG--GGTA---- ----------CCTGAAAGAGACGGGGAGAATGGA---ACCAAGTTGG---------AAAA CATACTT---CA-----GGATATCATCCAG--GAGAACTTCCCCAACCT----------- ---------AGCAAGACAGGC--CAAC--ATTCAAATTC-----AGGAAATCCAGAGA-A CCCCAGTAA------------GATACTC-CAT--------------GAGAAGATCAACCC C-------A---------------------AGACACATAATCATCAGATT------CTC- CAAGGTCGAAA---TGAAGG--AAAAAATGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGCCAGGT-------------- -----------CAC---CTACAAAGG-GAAGCCCA--------------TCAGACT--AA CAGCGGACCTC-----TCAGCAGAA--ACCCTA-CAAGC------CAG-AAGAGATTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAATTT--CCA--ACCCAGAA--------TTT---CATAT CCG-----------GCCAAACTAAGC-----TTCAT-AAGTGA-------AG-------- ------------------------G-AGAAATAAAATCCTTTTCAGACAAGC-AAATGCT GAGGGA-ATTTGTCACCACCAGGC---CTGCCTTGC-AAGAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCAC--------------TAAATA TGG----------------------------------------------------AAAGG AAAA---------------ACCATTA---------------------------------- -------------------------------CCAGCCACTACA----------------- ------------------------------------AAAACAC----------------- --------ACTGAAGTAACAAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCAATGACAC-------------------------TATGA A-------------------------------------------------GCAACTACAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CAACAAGTCTGCA--------------AA---ATAACCA GCTAG------------------------------------------------------- ------------------------------------------------------------ -------------CATCATG---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCACACATA--ACAATATTAAC-CTTAAAT-------G-T AAAT--GGGCT--AAATGC---CCCAATT----------------AAAAGAC------AC AGAA--TGGCAA----GCTG---------GAT-------AAAG---AGTCAAGACCCAT- ---CGG-------TGT-GCTGTATT-CAAGAGACCCATCT-CACGT--GCAAAGACACAC A-TAGGCTCAAAATAAAGGGA---T------------GGAGG----A-AAATTTACCAAG C--------------AAATGG------AAAGC---------------------AGAAA-A AAGCAG--GGGT----TGCAATCCTAGTTTC-TGACAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAAAGAC-AAAG-AAGGGCAT------TACAT------AAT GGTAAA---GGGATCAATT------CAACAA---GAAG--------AG-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAATACAGGAGCAC CCAG--ATT-CATAAAACAAGTTCTTAGAGACCT--AC----AAAGAGA---------CT TAGACTCCCAC------ACAATAATAGTGGGAGACTTTAACA----------------CC CCACT------GTCAAT-ATTAGACAGATCAT---------------------TGAGAC- -----AGAA-------------AATTAACAAGGATATTCAGGACTTGAAC-TCAGCTCTG GA------TCAAGTGG---ACCTGATAGATATCTACA--GA----ACTCTCCACCCAAAA AC---AACAGAATATACAT------TCTTCTCAGTGC-----CA--CAT-GGCACTTACT --C----TAAAATTGATCACATAATTGGAAGTAAAACACT-------------------- -CCTCAGCAAATGCAAAAGAA--CTGAAAT----------------CATAACAA------ -ACAGTCTCTCA---GACCACAGCACAA-TCAAATTAGAACTCAAG-------------- ----------------------------------------------ATTA--------AG --------------AAA-CTCACTCA---AAACCACACAA----CTACATGGAAA--T-T GAACAACCTG-CTCCTGAA---TG-ACTCCTG--GGTAAATAATGA--AAT--T-AAGGC AGAAATC---------------AAGAAGTTCTTT---GAAAC------------------ ------CAATGAGAACAA-AGA------------GACAAC--GTACCAGAATCTC-TGG- GA-----TGCAGCTAAAGCAGTG-----------------------------TTAAGAGG GAAA--TTTATAGCACTA----AATGC----CCACATCAAAAAGC---TAGAAAGATCT- --CAAATTGAC-ACCCTAA-CATCACAACTA---AAAGAAC--TAGAGAACC------AA GA-----GCAAACAAACC-------------CCAAAGC--TAGCAGAA-GACAAGAAATA ACC---AAGATCAGA-------------------GCGGAACTG---AA-G-GAGATAGAG ACAAA------AA------------------------------------AAA-CCC---T TCAAAAAATC-A---------ATG----AATCCA-GGAGCTG------GTTTTTTGAAAA AATTAA------------------------------------------------------ --------------------------------TAA-----AATAGATAGACTA---CTAG CTA------GACTAA--TAA------------AGAAG------------------AAAAG A---GAGA-AGAATC-----------------AAATAGA--------CACAA-----TA- ---------AAA-AATGATA--AA----------GGGGA---TATCACCACTGACCCC-A CA-GAAATA--CAAACAAC-CATCAG---------AGAATACT--ATAAA---------- -----------CAC---CTCTATGCAAATAA---ACTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----ACCCTCCCA----- -AGACTGAACCA---GGAAGAAGTTGAATCCCTGAAT----------------------- AGACC------------AA-TAACAAGTTCTGAAATTGAGG-C---------AGTAAT-- -AAATAGCCTACC------AACCAAAAAAAG---CCCAGGACC--AGATGG--------- ------------ATTTACA-GCTG--AA-------------------TTCTA-------- ----CCAGAGGTAC---AAAGAG-GAGCTGG--TA-CCATTT----------CTTCTGAA ACTATT----CC---AAACAATTGAA------AAGGAG-GG-----------ACTTCTCC CTAACTCATTTT-----ATGAGGCC-----AGCAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CTGGC AGA---------------------GAT---ACAACAAAAAA---AGAAAACTTC------ -------------A-GGCCAATAT---CCC----TGATGAACATCGAT------------ ------------GCAAAAATCC-TCA--------------------A----TAAAATACT GGC-AAACCG------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTTATCCA--CCACGAT------------C AAG---TCGGC-TT----------CATCCCC------------GG--GATGCAAGGCTGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--TGTA ---ATTCATCACAT------AAACAG----AACTAAAGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCCTTCGATAA---AATTCAACATCCCTT- ---------------CATGT---------T---A--AA-----AACTCTCAAT---AAAC TAGGTATTGATGGAACAT-----ACCTCAAAATAATAAG--------------------- ------AGCCATTTAT-GACAAA--------CCCACAGC-----------CAATAT--CA TACTGAATGGGCA-----AAA-GCTGGAAGC----ATTC---CCC----TT--GAAAACT GGCACA----AGACAAGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ATT---GGAAGTTCTGGCCAGGGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAGGGTATTCAAATAGGA---AGAGAG------GAAGTCAAA--T--------- ------TGTCTCTG-TT--T---GCAGA------TGACAT------GATCCTATATCTA- -GAAAACC--CCATCGT---CTCAGCCC---------A---------------AA--AGC TTCTTAAGCT---------GA--TAAGCAACTTCAGCAAAG--TCT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- GCAAAAAT----CACA-------------------------------------------- -----AGCATTCC--TA-TACACCAAC---------------AATAGACAAG-----CAG A------------------GAGCCAAATC-ATG----AATGAACTCCCATTCACAATTGC TACA------------------AAGAGAATA---------AAA------TACCTAGGAAT ACAGCT--------AA--C-AAGGGAAGTG---A---AGGACCTCT---TCAA-GGAGAA CTACAAACCAC------TGCTC-AAGGAAATCA-GA------------GAGG-------- ------------ACAC--AAAC--AAA---TGGA---AA--AACAT---------TCCA- --TGCTC------ATG-GATAGGAAGAATC-A---A---TATC--------------G-- TGAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--AGTAATTTATA-------------------GA---TTCAATGCT---ATT-- ------C-CCATTAAACT--A---------------------CCATTG-AC---ATTCTT ------------------------------------------CACAGAATTAG------- ----------------------AAAAAACTAC------TTTAAAA---TTCATATGGAAC C-------AAAAAAGAGCCC---AT--ATAGCCAAGACAATCCTAAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACG---CTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---AAAAACAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGATCTC------AG---AAATAAGA-- -CCGC----------------ACA-------TCTACAA----CCATCT--GATCTTT--- GACAAA--CCTGACAAAAACAAGC--A-------------------ATGGG--GA---AA GG------------ATTCCCTATT--TAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-CTAGCCA---------------TATGC-AGAAAA---TTG ---------AAACTGGACCCC---TTCCT-----------TACACC--TTA--T---ACA AAAA-TTAACT-CAAGATGG---AT---TAAAGAC---TTAAATGTA--AAACCCAAAAC TAT------------------------AAAAACCCTAGAA---------------GAAAA ---TCTA-------------------------GGCAATACCATTCAGGACATAG--GCA- -----TGGGCAAAGATT-----TCATGATGAA-AACATCA---AAAGCAATTGCAAC--- --AAAAGCA---AA----AAT---TGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAT-------------CATCAGAGTGAACAG------------------- ------A-------------CAACCT------ACAGAA--T-GGGAG---AAAATTTTT- --GCAATCTATCCAT--------CT-------GACAAAGGTC--------TA--ATATC- ---CAGAATCTACAAG-GA--ACTTAA---ACA------AA--TTTAC------------ ---AAG--------------AAAAAAACA---AAC--AACCCCA-TTAA---AAAGTGGG C--AAA---------GGA--CATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATTT---AT-GCGGCCAAC--AAACATATGAAAA AAA----------GCTCAACATCACTG-ATCATTA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ATGCCAGTCAGAATGGCGATTAT---T A--AAAAG-------TCAAGAA-----ACAACA-GATG--C------------------- ------TGGC-GAGGCTGTG----------GAGAA------------------------- ------------ATAGGAACGCTTTT-ACACTGTTGG--TGGG----------------- ----------AATGT--A-------------AATT---AGTTC----AACCATTGTGG-- ------AAGACAGTG--TGGCG--A-TTCCTC--AAAGACCTAGAA--CCAGAAATACC- -ATTT---GA--CCCAGCAATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAA------------TATAAATCA----T------- --------------TCTATTAT--AAAGATACATGC---------ACATG----TATGTT CATT--GCAGCACTATTCACAA-TAGCAAAGACAT--G--GA--ATCA--ACCCAA---A TGCCCATCA---ATGATAG-----ACTGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AGGAATGAGATCATGTCCTTT---- ------------------------------------------------------------ --------GCAGGGACATGGATGGAG-C---TGGAAGCCATTATCCTCAGCAA------- ------------------------------------------------ACTAACACAGGA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAACAC-CG-------- ---CAT---GTTCTCACTTAT----------AAGTGGGAGCCT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAACA-------ATGAGAA---------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GGA--------GGGGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AACACAC-----------------------------------------------A CTG-------GGGCCTGTCG---------------GGGGGGGGCTGGGCGGGGGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GAGCATCAGGATAAAT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AGCTAATGCATG--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----CTGGGCTTAATACCTAGGTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ATGGGTTGATAGGTGCAGCAAACCACCATGGC------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACACGTTTACCTATGT------------------------------------------- --------------------------------------------AACAAA---------- -------------------CCTGCACGTCCTGCACATGTATCCCG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAACTTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ATAAAATTAAATAAAA-------------------------------------------- ------ >L1PA11 ------------------------------------------------------------ ------------------------------------------------------------ --------------------CAAG-----------------ATGGCCGATTAGAAGCAGC TGTGGTCCG---------------------------CAGCACTCACAGAG---------- ---------------------------------------AGGAATGAAAAGGGGCG---- ----------AGTGAATTCAGCACCTTCAACTGAAATATCCAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------GTTCTCACATTGGG------ACTGACTAGGC------------- --------AAACAACTTGACCCACGGAGAACGAA---------G-AAAAGCAGGGGGGGG TGACGGCCCACCCG---------------------------------------------- ------------------------------------------GGAGCGGCACGGAGCCAA GGGAACCCCCACCCCCAGCCAAGGGAAGCGGTGAGTGATTGTGCGACCCCGCCCGGGAAA CCACGCTTCTCC----------------------------------------CATGGATC TTTGCAACCCGTGGATCAGGAGATCCCCTCGTGAGCCCACGCCACCAGGGCCTTGGGTCC GAT------------------------------------------ACACAGAGCTGTGTG GAGTCTCGGCAGAGCAGCCGCTCAGGCACACACAGAGACCCAGGAGTTTTACATACTCTG GCCCCGGGATCCCCAGCAAGGCGGGA---------------------------------- ------------------------------------------------------------ -------------------------------GATCCATCTGTACATATCCCTAGGAAGGG GGCTGAATCCAGGGAGCCAAGCAGCGTCATTCTGCGGGCCCCACTTCCACGGCACCTCAC AAGTTAAGACCCACTG-------------------------------------------- -----------------GCTTGGAATTCCAGCCAGCCAGTGGCAGCAGGCTGGAGTCTGC CTGAGATGGGACTGAGTTCCCGGGGGGAGGGGC------------GGCCACCATCTCTGT GGTTCGGTAGACTCAGCTGTTCCAGCCTGCCGGCT------------------------- ---------------------------------------TTGGAGAATACAGATGGTCCG GA-------------------CGAGGAAGGGTCCCCCACAA------------------- ------------------------------------------------------------ -----GCAGCACAGCTGCTTTGCCAGATCGTGGCC------------------------- ------------------------------------------------------------ ----------------------------------------AGACTGCTTCTTTAAGTGGG ACCCCAATCCATTCCTCCTCACTGGGCGGGACCTCCCTGTGGGGGCTTCAGCCACTCCAG CCAGGGTTCTACGGACAGAGCTCTGATCTCTCCCTGGGACGGAGCTCCTGGGGGGAGGGG CGGCCACCATCTCTGTGG------------------------------------------ ------------------------------------------------------------ --------------------TTCGGTCGAC-------TCAGCCGTTCCAGCCTGCTGGCT TTGGAGAGTCCAAGCGGTCCGGACGAGG-------------------------------- ------------------------------------------------------------ -AAGGGTTCCCCCCAATGCAGCACACCTGCTCTACCAAAAAGCAGCCAGACTGCTTTTTA AGCAGGTCCCTGATCCCGTTCCTCCTGACT------------------------------ ------------------------------------------------------------ --------------------------------------------GGGTGAGACCTCCCAA CAG-------GGGTCTCCAGCCACCTCCTACAGGTGCGTTCGGGCTGGCAACAG------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTCAGTACCCCTGGGACGGAG CTTCCAGAGGAAGG--------------------------------AGCAGGCTGCCATC TT------------TGCTGTTTCGCAGCCTTCACTGGTGATACCTCCAGGTACGGG---- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAAACCGAGGCAACTAGGGTCTGGAGCGGA----CCCCCAGCAAACCGCAGCAGC CCTACAGTAGAGTGGCCTGACTGTTA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AAAGAAAAA-----------CAAACAAAAAAAAAAAA ACAA-------------------------------------------------------- ------------------------------------------------------------ --------------CAACAACAAAAAAAGACCCCACAAAAACCCCAT------------- ----------------------------------------------TCAAAGGTCAGC-- ---------------------------------------AACCTCAAAGAT--------- ---------CGAAG---------------------------------------------- -GTAGATAAGCCCACAAAG----------------------------------------- ------------------------------------------------------------ -------------------------------TGAGAAAGAA-----TCAATGCAAAAACA CTG-------------------------------------AAAACTCAA--------AAA GCCA----GAGTGCCT-------------CTTC--TCCT--CCAA---A-TG-------- -------ACC----ACAACACCTC-------------------TC-CAG---CAAGGGCA CAGAACT----------GGGCTGAGG---CTGAGATGGCTGAATTGACAGAAGT------ ------AGGC------------TTCAGAAGGTGGGT-AATAACGAACTTCGCTGAGCT-- --AAAGGAGCATGTT--------------------------GTAACCCAATGC-----AA AGAAGCT---------------------------------------------AAGAATCA T-GATAAAA--------------------------------------------------- -CAATACA----------GGAGCTGATAGCCAGA-------------------------- -------------------------------------------ATAGCCAGTTTAGAGAG ----------GAAC---------------ATAACTG------ACC---------TGATG- GAGC----TGAAA---------AACAC---AACACAAGAACTTCACAATGCAATCACA-- ---AGTATCAATAGCAGA----------------ATAG--------------------AC C--AAGT------------------GGAGGAAAG-AAT-CTCAG--AGCTTGAAGAC--- -TATCTTTCTGAAA-T-----AAGACAGGCAG---------ACAAGAATAGA---GAAAA AAGA---ATGAAAAGG-AA---------TGA---ACAAAACCTCT--GAGAAATATGGG- ATTAT--------G---TAAAGAG--ACCGAACCTATGA--C-TGATTGG--GGTA---- ----------CCTGAAAGAGACGGGGAGAATGGA---ACCAAGTTGG---------AAAA CATACTT---CA-----GGATATCATCCAG--GAGAACTTCCCCAACCT----------- ---------AGCAAGACAGGC--CAAC--ATTCAAATTC-----AGGAAATGCAGAGA-A CCCCAGTAA------------GATACTC-CAT--------------GAGAAGATCAACCC C-------A---------------------AGACACATAATCATCAGATT------CTC- CAAGGTCGAAA---TGAAAG--AAAAAATGT----------------------------- -------------TAAGGGC--AGCCAGAGA---GAAAGGCCAGGT-------------- -----------CAC---CTACAAAGG-GAAGCCCA--------------TCAGACT--AA CAGTGGACCTC-----TCAGTGGAA--ACCCTA-CAAGC------CAG-AAGAGATTG-- -----------GGG-GCCAATA-T-------TCAACA--TTCT-------------TAAA GAAAA---------------GAATTT--CCA--ACCCAGAA--------TTT---CATAT CTG-----------GCCAAACTAAGC-----TTCAT-AAGCGA-------AG-------- ------------------------G-AGAAATAAGATCCTTTTCAGACAAGC-AAATGCT GAGGGA-ATTCGTCACCACCAGGC---CTGCCTTGC-AAGAG------------------ --------------------CTCCTGAAGGA----------------------------- -----------------------------------AGCAC--------------TAAATA TGG----------------------------------------------------AAAGG AAAA---------------ACCATTA---------------------------------- -------------------------------CCAGCCACTACA----------------- ------------------------------------AAAACAC----------------- --------ACTGAAGTAACACA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CCAGTGACAC-------------------------TATGA A-------------------------------------------------GCAACCACAT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAACAAGTCTGCA--------------AA---ATAACCA GCTAG------------------------------------------------------- ------------------------------------------------------------ -------------CATCATG---------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCACACATA--ACAATACTAAC-CTTAAAT-------G-T AAAT--GGGCT--AAATGC---CCCAATT----------------AAAAGAC------AC AGAA--TGGCAA----GCTG---------GAT-------AAAG---AGCCAAGACCCAT- ---CGG-------TAT-GCTGTCTT-CAAGAGACCCATCT-CACGT--GCAAAGACACAC A-TAGGCTCAAAATAAAGGGA---T------------GGAGG----A-AAATTTACCAAG C--------------AAATGG------AAAAC---------------------AGAAA-A AAGCAG--GGGT----TGCAATCCTAGTTTC-TGACAAAACAGACTTTAAA-CC------ ----AACAAAGA---TCAAAAAAGAC-AAAG-AAGGGCAT------TACAT------AAT GGTAAA---GGGTTCAATT------CAACAA---GAAG--------AG-CTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAATACAGGAGCAC CCAG--ATT-CATAAAGCAAGTTCTTAGAGACCT--AC----AAAGAGA---------CT TAGACTCCCAC------ACAATAATAGTGGGAGACTTTAACA----------------CC CCACT------GACAAT-ATTAGACAGATCAT---------------------CAAGAC- -----AGAA-------------AATTAACAAAGATATTCAGGACCTGAAC-TCAGCTCTG GA------TCAAGTGG---ACCTGATAGATATCTACA--GA----ACTCTCCACCCCAAA AC---AACAGAATATACAT------TCTTCTCATCGC-----CA--CAT-GGCACTTACT --C----TAAAATTGATCACATAATCGGAAGTAAAACACT-------------------- -CCTCAGCAAATGCAAAAGAA--CTGAAAT----------------CATAACAA------ -ACAGTCTCTCA---GACCACAGCACAA-TCAAATTAGAACTCAAG-------------- ----------------------------------------------ATTA--------AG --------------AAA-TTCACTCA---AAACCACACAA----CTACATGGAAA--T-T GAACAACCTG-CTCCTGAA---TG-ACTCTTG--GGTAAATAATGA--AAT--T-AAGGC AGAAATC---------------AAGAAGTTCTTT---GAAAC------------------ ------TAATGAGAACAA-AGA------------GACAAT--GTACCAGAATCTC-TGG- GA-----TGCAGCTAAAGCAGTG-----------------------------TTAAGAGG GAAA--TTTATAGCACTA----AATGC----CCACATCAAAAAGC---TAGAAAGATCT- --CAAGTTAAC-AACCTAA-CATCACAACTA---AAAGAAC--TAGAGAACC------AA GA-----GCAAACAAACC-------------CCAAAGC--TAGCAGAA-GACAAGAAATA ACC---AAGATCAGA-------------------GCTGAACTG---AA-G-GAGATAGAG ACAAA------AA------------------------------------AAA-CCC---T TAAAAAAATC-A---------ATA----AATCCA-GGAGCTG------TTTTTTTAAAAA AATTAA------------------------------------------------------ --------------------------------TAA-----AATAGATAGACCA---CTAG CTA------GACTAA--TAA------------AGAAG------------------AAAAG A---GAGA-AGAATC-----------------AAATAAA--------CACAA-----TC- ---------AGA-AATGATA--AG----------GGGGA---TATCACCACTGACCCC-A CA-GAAATA--CAAACAAC-CATCAG---------AGAATACT--ATAAA---------- -----------CAC---CTCTATGCACATAA---ACTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----ACCCTCCCA----- -AGACTGAACCA---GGAAGAAATTGAATCCCTGAAT----------------------- AGACC------------AA-TAATGAGTTCTGAAATTGAGG-C---------AGTAAT-- -AAATAGCCTACC------AACCAAAAAAAG---CCCAGGACC--AGACAG--------- ------------ATTCACA-GCTG--AA-------------------TTCTA-------- ----CCAGAGGTAC---AAAGAA-GAGCTGG--TA-CCATTT----------CTACTGAA ACTATT----CC---AAAAAATTGAA------AAGGAG-GG-----------ACTCCTCC CTAACTCATTCT-----ATGAGGCC-----AGCAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CTGGC AGA---------------------GAT---ACAACAAAAAA---AGAAAACTTC------ -------------A-GGCCAATAT---CCT----TGATGAACATCGAT------------ ------------GCAAAAATCC-TCA--------------------A----TAAAATACT GGC-AAACCA------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGCTTATCCA--CCACGAT------------C AAG---TTGGC-TT----------CATCCCC------------GG--GATGCAAGGTTGG -T----------------------TC-AAC-----ATACGC--AAATCAATAAA--TGTG ---ATTCATCACAT------AAACAG----AACTAAAGACAAAAAC---CACATGA---- -TTATCTCAATA---GATGC---AGAAAAGGCCTTCGATAA---AATTCAACATCCCTT- ---------------CATGT---------T---A--AA-----AACTCTCAAT---AAAC TAGGTATTGAAGGAACAT-----ACCTCAAAATAATAAG--------------------- ------AGCCATATAT-GACAAA--------CCCACAGC-----------CAATAT--CA TACTGAATGGGCA-----AAA-GCTGGAAGC----ATTC---CCC----TT--GAAAACC GGCACA----AGACAAGG-ATGC--CCTCTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ATT---GGAAGTTCTGGCCAGGGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAGGGTATTCAAATAGGA---AGAGAG------GAAGTCAAA--T--------- ------TATCTTTG-TT--T---GCAGA------TGACAT------GATCCTATATCTA- -GAAAACC--CCATCGT---CTCAGCCC---------A---------------AA--AGC TTCTTAAGCT---------GA--TAAGCAACTTCAGCAAAG--TCT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- GCAAAAAT----CACT-------------------------------------------- -----AGCATTCC--TA-TACACCAAC---------------AACAGGCAAG-----CAG A------------------GAGCCAAATC-ATG----AATGAACTCCCATTCACAATTGC TACA------------------AAAAGAATA---------AAA------TACCTAGGAAT ACAGCT--------AA--C-AAGGGAAGTG---A---AGGACCTCT---TCAA-GGAGAA CTACAAACCAC------TGCTC-AAAGAAATCA-GA------------GAGG-------- ------------ACAC--AAAC--AAA---TGGA---AA--AACAT---------TCCA- --TGCTC------ATG-GATAGGAAGAATC-A---A---TATC--------------G-- TGAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--AGTAATTTATA-------------------GA---TTCAATGCT---ATT-- ------C-CCATTAAACT--A---------------------CCATTG-AC---ATTCTT ------------------------------------------CACAGAATTAG------- ----------------------AAAAAACTAT------TTTAAAA---TTCATATGGAAC C-------AAAAAAGAGCCC---AA--ATAGCCAAGACAATCCTAAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACG---CTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---AAGAACAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACTC------AG---AAATAAGA-- -CCAC----------------ACA-------CCTACAA----CCATCT--GATCTTC--- GACAAA--CCTGACAAAAACAAGC--A-------------------ATGGG--GA---AA GG------------ATTCCCTATT--TAATAAATGG---------------TGCTG---- ------G-GAGAAC--TGG-CTAGCCA---------------TATGC-AGAAAA---TTG ---------AAACTGGACCCC---TTCCT-----------TACACC--ATA--T---ACA AAAA-TTAACT-CAAGATGG---AT---TAAAGAC---TTAAATGTA--AAACCCAAAAC TAT------------------------AAAAACCCTAGAA---------------GAAAA ---TCTA-------------------------GGCAATACCATTCAGGACATAG--GCA- -----CGGGCAAAGATT-----TCATGATGAA-AATGCCA---AAAGCAATTGCAAC--- --AAAAGCA---AA----AAT---TGACAAA-TGGGAT----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAT-------------CATCAGAGTGAACAG------------------- ------A-------------CAACCT------ACAGAA--T-GGGAG---AAAATTTTT- --GCAATCTATCCAT--------CT-------GACAAAGGTC--------TA--ATATC- ---CAGAGTCTACAAG-GA--ACTTAA---ACA------AA--TTTAC------------ --------------------AAGAAAAAA---AAC--AACCCCA-TTAA---AAAGTGGG C--AAA---------GGA--CATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATAC---AT-GCGGCCAAC--AAACATATGAAAA AAA----------GCTCAACATCACTG-ATCATTA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACGCCAGTCAGAATGGCTATTAT---T A--AAAAG-------TCAAAAA-----ACAACA-GATG--C------------------- ------TGGC-GAGGTTGCG----------GAGAA------------------------- ------------AAAGGAATGCTTTT-ACACTGTTGG--TGGG----------------- ----------AGTGT--A-------------AATT---AGTTC----AACCATTGTGG-- ------AAGACAGTG--TGGCG--A-TTCCTC--AAAGACCTAGAG--GCAGAAATACC- -ATTT---GA--CCCAGCAATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAGGAA------------TATAAATCA----T------- --------------TCTATTAT--AAAGATACATGC---------ACGCG----TATGTT CATT--GCAGCACTATTCACAA-TAGCAAAGACAT--G--GA--ATCA--ACCTAA---A TGCCCATCA---ATGATAG-----ACTGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AGGAACGAGATCATGTCCTTT---- ------------------------------------------------------------ --------GCAGGGACATGGATGGAG-C---TGGAAGCCATTATCCTCAGCAA------- ------------------------------------------------ACTAATGCAGGA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAACAC-CG-------- ---CAT---GTTCTCACTTAT----------AAGTGGGCT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAATG-------ATGAGAA---------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACACAT----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GGG--------GGGGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AACACAC-----------------------------------------------A CTG-------GGGCCTGTCG---------------GGGGGTGGGGGGGTTGGGGGAGG-- -------------------------------------------------GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GAGCATCAGGAAGAAT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AGCTAATGGATG--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----CTGGGCTTAATACCTAGGTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ATGGGATGATCTGTGCAGCAAACCACCATGGC------------- ------------------------------------------------------------ ------------------------------------------------------------ -ACACGTTTACCTATGT------------------------------------------- --------------------------------------------AACAAA---------- -------------------CCTGCACATCCTGCACATGTACCCCT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAACTTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AGTTGAAGAAAAAAA----------------------------------------- ------ >L1PA16 ------------------------------------------------------------ ------------------------------------------------------------ -----------TTTTTTTTCCAAG-----------------ATGGCGGATTAGAGGCTTT TAGCATGCC---------------------------TCAGCCACTTGGAAAT-------- ----------------------------------AGCAAGATAGTGCATAAAGATCAACT CTGTGAG----------------CTTTAATTCAAGAAGGAAAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------TGGGAATCCACTGGAATCATGAAG------GACACCCCAGATCCCCTTCCGGGG AGGAGAACACCAGCAAACAGCCCCCGTGACAGCG---------T-CTGGCTGATAAAAGT GAGTGAAGCCCCAG---------------------------------------------- ------------------------------------------------------------ ------------------TACATGAGAGAGGCAG-----AG---AGCCTCCCTCTGTGAC TCACCTTTCCAC----------------------------------------TGGGGATC TAAGCAACCCAGGCCAAGGGAGAGCACTTTGTTTCTCCCAAGCCCTGGAGCTAAC----- ---------------------------------------------TTGGGGAGAGGCTTG GAGACGCTGTGAGGGAAAGACACCGGGAAAAGCTGCAGGCATTTTCCCAGAC-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------CTGGGACTGGGAGCAGGACGC----CATTTTTAATCC GGGCGCATACAAAGTCAGCCATTCTTTGGTGACCCGGCAGTGTGGCCATGCAGGCATTTT AGTCTTGGGCCAGAGA-------------------------------------------- ---------------------------------------------------------TTG GAGCGCCTGCTCTGGAGCAGGGTAGGGGCCTC-------------CACAGCCAGAACTGT GGAAAGCACCTCAGCAGTA----------GGTGC----------------------TGGA ATTGTGCTCTCCCCC------------ATTGCAGGC---CTGGGGCAGGAGGAGAGCTGC TACAGCTGCAGTTTCTC----CTGGGTGGTGAGACTTGCAG------------------- ------------------------------------------------------------ ----CCAGGGCCAGCTTGGCGACCTGGAACTGGTCTGCAT-------------------- ------------------------------------------------------------ ----------------------------------------GTGCCATTGCTGGGTGCC-- ---------CCAGCCTGCTCCCCTGAGATCGTGGTGCAGTGGGGCCCTCTCTGCTCCATG CCCAGGCAGA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------TCTCCAGGCA-------TTTGGAGCACCCACTTGCCTGGA TCAGCAGCCTGAGCTGCCCCACCCTTCCTGTGCAGAGATCTGTGTTCCGTCGGGGCCTCT CTGCTCCCCGCCCAGGCAGATCTCCAGGCATTCAGAGCACCCGCTTACCTGGTTCAGCAG CCTGAGCCACCCCACCCTTCCTGGACATAGATTGTGGTGCAGCAAGGCCTCTCTGCTCCA TGCCC-AGGCAGATCTCCAGGCATTTGGAGCACCTGCTTGCCTGGATCAGCAGCCTGAGC CGCCCCACCCTTCCTGTGCAGAGATTCTGGTGCA-------------------------- --------------------------------------------GGGGGGCCCTCTCTGC TCCATGCCCAGGCAGATCTCCAGGCATTCAGAGCACCTG--------------------- ------------------------------------------------------------ -----------------------------------------------------------C TTGCC-----------------TGGTTCAGCAGCCTGAGTTGCCCCACCCCTCCTGTGCA GAGATTTTGGTGCA--------------------------------GGGGGGCCCTACCC TC------------TCTGCTCCATGCCCAGGCAGATCTCCAGGCATCTGGAGCACCCACT CTCCTGGATTAGGAGTTTAGGCTGCCCCCCCTCCCGTGCAGAGAACTTGGGGCGAGGAGG TTTCCCAGCCATGCCTAGGCACACCTCTGGGTGCTTGG---------------------- ----TGGCCGCCCACTGGATTCTCCCTCGGCGCTG----GTGCTTGTGCCTGCCATCAGG GGACCTGTAGGTGGGCCTGCCTGGTC---------------------------------- ------------------------------------------------------------ --------------------------------------------------TGGCCCTGCC CATCTTGGCTCCCGCCCCCCAGGGCCCCGGGGCTGAGCAGGGAGCTCAGACCACTGTGCA CTCCATGAATCAGCCCATTGCCTGAGGCAACAGAGAGCTTCTCCCAGTAAACAAGGATCA AGTATATACCCAGCCATGTTGGCTGCAGCTATTACCTATAAGTGCCATCTACTGGCTTGT AGGTCAAACTGCACAGCCCAATATAAAACCTGCCAAAAGAAGTGCAT------------- --A-----------GGGCTATAGAAGCAAAGCCAAAAGACCCTACCCAGCATTCTCTA-- ----------------------------------------------CAGTCACACCCCCT AGGGAGGGGGGAAAAGGAAAAAGGAAAAAAAAAAGAA--AATATTATAGGA--------- ---------AAAAAAAAAAAAAAAAAAAAAGAAAAAATCCTACCCGCATGAAAATAATTA CAAAAATTA-------------------GAAGTGCCAGCGTCTCCAG------------- ------------------------------------------------------------ -------------------------------TGAGAAAGAA-----CCAGCACAAGAACT CTG-------------------------------------GCAACTCTA--------AAA GCCA----GAGTGTCT-------------TCTT--ACCT--CCAA---A-TG-------- -------ACC----ACACTAGCTC-------------------TC-CAG---CAATGGTT CTTAACC----------------AGA---CTGAAATGGCTGAAATGACAGACAT------ ------AGAA------------TTCAGAATCTGGAT-GGCAAGGAAGCTCATTGAGAT-- --ACAGGAGAAGGTT--------------------------GAAACCCAATCC-----AA GGAAACC----------------------------------------------------- --AGTAAAA--------------------------------------------------- -TAATCCA----------AGAGTTGAAAGACAAA-------------------------- -------------------------------------------ATAGCCATTTTAAGAAA ----------GAAC---------------CAAACTG------AAC---------TTCTG- GAAT----TGAAA---------AATTC---ACTACAAGAATTTCATAATACAATTGGA-- ---AGTATTAACAACAGA----------------ATAG--------------------AC C--AAGC------------------TGAGGAAAG-AAT-CTCAG--AGCTTGAAGAC--- -CAGTTCTTTGAAT-C-----AACTCAGTCAG---------ACAAAAATAAA---GAAAA AAGA---ATTTTAAAA-AA---------TGA---ACAAAACCTCT--GAGAAATATGGG- ATTAT--------G---TAAAGAG--ACCAAACCTATGA--C-TCATTGGGACATT---- ----------CCTGAGAGAGAAGGAGAGAGAGTA---AGCAACTTGG---------AAAA CATATTT---GA-----GGATATAGTCCAT--GAAAATTTCCCCAATCT----------- ---------CGCTAGAGAGGT--TGAC--ATGCAAATTC-----AAGAAATTCAGAGA-A CCCCTGCGA------------GATACTA-TAC--------------AAGATGACCATCCC C-------A---------------------AGACACATAGTCATCAGATT------CAC- CAAGGTCAATG---CAAAAG--AAAAAATCT----------------------------- -------------TAAAGGC--AGCTAGAGA---GAAGGGTCAGGT-------------- -----------CAC---TTACAAAGG-GAACCCCA--------------TCAGGCT--AG CAGTAGACCTC-----TCAGCAGAA--ACCTTA-CAAGC------CAG-AAGAGATTG-- -----------GGG-GCCTATT-T-------TCAGCA--TCCT-------------TAAA GAAAA---------------GAAATT--CCA--ACCAAGAA--------TTT---CATAT CCT-----------GCCAAACTAAGC-----TTCAT-AAGTGA-------AG-------- ------------------------G-AGAAATAAAATCCTTTTCAGACAAGC-AAATGCT AAGGGA-ATTTATTACCACTAGAC---CAGCCTTAC-AAGAG------------------ --------------------GTCCTTAAGGG----------------------------- -----------------------------------AGTGC--------------TAAACA TGG----------------------------------------------------AAATG AAAG---------------AACAATA---------------------------------- -------------------------------CCTGCCACCACA----------------- ------------------------------------AAAACAC----------------- --------ACTTTAAGTA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------CATA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GC-------- --------------------CCACAGACCC-------------------------TATAA A-------------------------------------------------GCAACCACAC ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AATAGAAACTACA--------------AA---GCAACCA GCTAA------------------------------------------------------- ------------------------------------------------------------ -------------CAACTTCAC-------------------------------------- ------------------------------GATACAAAA--------------------- ------------------------------------------------------------ --------------------CCTCACATA--TCAATATTAAC-CTTGAAT-------G-T AAAT--GGTCT--AAATGC---CCCACTT----------------AAAAGGC------AC AGAG--TGGCAA----GTTG---------GAT-------AAAA---AAACAAGACCCAT- ---CTA-------TCT-GCTGTCTT-CAAGAGACCCATCT-CACAT--GTAATGACACCC A-TAGGCTCAAAGTAAAGGGT---T------------GGAGA----A-AGATCTATCATG C--------------AAATGG------AAAAC---------------------AAAAA-A GAGCAG--GGGT----CACTATTCTTATATC-AGATAAAACAGACTTTAAA-CC------ ----AACAACAG---TAAAAAAGGAC-AAAG-AAGGGCAT------TACAT------AAT GATAAA---GGGTTCAATT------CAACAA---GAAG--------AC-TTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAACATTGGAGCAC CCAG--ATT-CATAAAACAAGTACTTCTAGACCT--AC----GAAAAGA---------CT TAGACAGCCAC------ACAATAATAGTGGGGGACTTCAACA----------------CC CCACT------GACAGC-ATTAGACAGATCAT---------------------TGAGGC- -----AGAA-------------AACTAACAAAGAAATTCTGGACTTAAAT-TCGACACTT GA------CCAATTGG---ACCTAATAGACATCTACA--GA----ATACTCCACCCATCA AC---CACAGAATATACAT------TCTTCTCATCTG-----CA--CAC-AGAACATACT --C----TAAGATTGACCACATGCTCAGCCATAAAGCAAG-------------------- -TCTCAATAAATTCAAAAAAA--TTAAAAT----------------CATACCAA------ -CCATACTCTTG---GACCACAGTGGAA-TAAAAATAGAAATCAAT-------------- ----------------------------------------------ACCA--------AG --------------AAG-ATCTCTCA---AAACCACACAA----TTACATGGAAA--T-T AAACAACTTG-CTCCTGAA---TG-ACTTTTG--GGTAAACAATAA--AAT--T-AAGGC AGAAATC---------------AAAAAATTCTTT---GAAAT------------------ ------AAATGAAAACAG-AGA------------CACAAC--ATACCAAAATCTC-TGG- GA-----TGCAGCAAAAGCAGTG-----------------------------TTAAGAGG AAAG--TTTATAGCACTA----AATGC----CTACATCAAAAAGT---TAGAAAGATCT- --CAAATTAAC-AATCTAA-CATCACACCTA---GAGGAAC--TAGAAAAAC------AA GA-----ACAAACTAACC-------------CCAAAGC--TAGCAGAA-GAAAAGAAATA ACT---AAAATCAGA-------------------GCAGAACTG---AA-T-GAAATTGAG ACCCA------AA------------------------------------AAT-CCA---T ACAAAGAATC-A---------ATA----AAACCA-AAAGTTG------GTTCTTTGAAAG GATAAA------------------------------------------------------ --------------------------------CAA-----GATTGATAGACCA---CTAG CTA------GATTAA--CAA------------AGAAA------------------AAAAG -------AGAGATCC-----------------AAATAAG--------CACAA-----TC- ---------AGA-AATGACA--AA----------GGTGA---CATTACAACTGATCCC-A CA-GAAATA--CAAAAGAT-CCTCAG---------AGACTATT--ATGAA---------- -----------CAC---CTCTATGCACACAA---ACTAGAAAATCTAG---AGGAAAT-- GGATAAATTCCT----------GGAAACA---------CAC-----AACCTCCCA----- -AGATTGAATCA---GGAAGAAATTGAAACCCTGAAC----------------------- AGACC------------AA-TATTAAGTTCTGAAATTGAAT-C---------AGTAAT-- -AAAAAACCTACC------AACCAAAAAAAG---CCCTGGACC--AGATGG--------- ------------ATTCACA-GCCA--AA-------------------TTCTA-------- ----CCAGATATAC---AAAGAA-GAGCTGG--TA-CCAATT----------CTACTGAA ACTATT----CC---AAAAAATTGAG------GAGGAG-GG-----------ACTCCTCC CTAACTCATTCT-----ATGAAGCC-----AGCAT---CACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CTGGC AAA---------------------GAC---ACAATGAAAAA---AGAAAACTAC------ -------------A-GGCCAATAT---CCC----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACCA------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGTTAATTCA--CCATGAT------------C AAG---TAGGC-TT----------TATTCCT------------GG--GATGCAAGGTTGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--TGTG ---ATTCACCACAT------AAACAG----AATTAAAAACAAAAAC---CATATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCTTTTGATAA---AATCCAACATCCCTT- ---------------CATGA---------T---A--AA-----AACCCTCAAC---AAAC TAGGCATCAAAGGAACAT-----ACCTCAAAATAATAAG--------------------- ------AGCCATCTAT-GACAAA--------CCCACAGC-----------CAACAT--CA TACTGAATGGGCA-----AAA-GCTGGAAGC----ATTC---CCC----TT--GAGAACT GGAACA----AGACAAGG-ATGC--CCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAAGGCATCCAAATAGGA---AAAGAA------GAAGTCAAA--C--------- ------TATCTCTC-TT--C---ACTGA------TGATAT------GATTCTATACCTA- -GAAAACC--CTAAAGA---CTCTGCCA---------A---------------AA--GGC TCCTAGAACT---------GA--TAAACAACTTCAGTAAAG--TTT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCATTTC--TA-TACACCAAT---------------AACATTCAAG-----CTG A------------------GAGCCAAATC-AAG----AATGCAATCCCATTTACAATAGC CACA------------------AAAAAAATA---------AAA------TACCTAGGAAT ACATCT--------AA--C-CAAGGAGGTG---A---AAGATCTCT---ACAA-GGAGAA CTACAAAACAC------TGCTG-AAAGAAATCA-TA------------GATG-------- ------------ACAC--AAAC--AAA---TGGA---AA--AACAT---------TCCA- --TGCTC------ATG-GATTGGAAGAATC-A---A---TATT--------------G-- TTAAAATG-----------------------------------------GCCAT--ACTG CCC-AA--AGCAATCTACA-------------------GA---TTCAATGCT---ATT-- ------C-CTATCAAACT--A---------------------CCAATG-TC---ATTTTT ------------------------------------------CACAGAATTAG------- ----------------------AAAAAACTAT------TCTAAAA---TTCATATGGAAC C-------AAAAAAGAGCCC---AA--ATAGCCAAAGCAATCCTAAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACA---TTACCTGACTTCAAACT-----A TACTAT-------------------------AA---GGCTACAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---AAAAACAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAG-- -CCAC----------------ACA-------CCTACAA----CCATCT--GATCTTT--- GACAAA--GTTGACAAAAATAAGC--A-------------------ATGGG--GA---AA GG------------ACTCCCTATT--CAATAAATGG---------------TGCTG---- ------G-GATAAC--TGG-CTAGCCA---------------TATGC-AGAAGA---ATG ---------AAACTGGACCCC---TACCT-----------TTCACC--ATA--T---ACA AAAA-TTAACT-CAAGATGG---AT---TAAAGAT---TTAAATGTA--AGACCTCAAAC TAT------------------------AAGAATCCTAGAA---------------GAAAA ---CCTA------G------------------G-AAATACCATTCTGGACATTG--GCC- -----TTGGGAAAGAAT-----TTATGACTAA-GTCCTCA---AAAGCAATTGCAAC--- --AAAAACA---AA----AAT---TGACAAG-TGGGAC----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAT-------------CAACAGAGTAAACAG------------------- ------A-------------CAACCT------ACAGAA--T-GGGAG---AAAATATTC- --ACAAACTATGCAT--------CT-------GACAAAGGTC--------TA--ATATC- ---CAGAATCTATAAG-GA--ACTTCA------------AT--TCAAC------------ ---AAG------CA------AA--AAACA---AAT--AACCCCA-TTAA---AAAGTGGG C--AAA---------AGA--CATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATAC---AA-GTGGCCAAC--AAACATATGAAAA AAT----------GCTCAACATCACTA-ATCATCA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACACCAGTCAGAATGGCTATTAT---T A--AAAAG-------TCAAAAA-----ACAACA-GATG--T------------------- ------TGGG-GAGGCTGTG----------GAGAA------------------------- ------------AAGGGAATGCTTAT-ACACTGTTGG--TGGG----------------- ----------AATGT--A-------------AATT---AGTTC----AGCCACTGTGG-- ------AAAGCAGTT--TGGAG--A-TTTCTC--AAAGAACTTAAA--ACAGAACTACC- -ATTT---GA--CCCAGCAATCCCA---------------------TTACTGGG-TATA- --------------TA-CCCAAAAGAA------------AATAAATCA----T------- --------------TCTACCAA--AAAGACACATGC---------ACTCA----TATGTT CATC--ACAGCACTATTCACAA-TAGCAAAGACAT--G--GA--ATCA--ACCTAG---G TGCCCATCA---ATGGTGG-----ATTGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATAA----AA----------------------AAGAATAAAATCATGTCCTTT---- ------------------------------------------------------------ --------GCAGCAACATGGATGCAG-C---TGGAGGCCATTATCCTAAGCAA------- ------------------------------------------------ATTAATGCAGGA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAATAC-CA-------- ---CAT---GTTCTCACTTAT----------AAGTGGGCTA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AACAT-------TGGGTA----------------CTC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACATAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------TGGCAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AATAGAC-----------------------------------------------A CTG-------GGGACTACTA----------------GAGGGGGGAGGGAGGGAGGGGG-- -------------------------------------------------GC--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AGGGTTGAAA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AACTATTGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----CTATGCTCACTACCTGGGTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ATGGGATCATTTGTACCCCAAACCTCAGCATC------------- ------------------------------------------------------------ ------------------------------------------------------------ -ATGCAAT-ATACCCAT------------------------------------------- -------------------------GT-----------------AACAAA---------- -------------------CCTGCACATGTACCCCT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAATCTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AT AAAAGTTGAAATAAAA-------------------------------------------- ------ >L1MC5 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TGTGCAGAAA-----GCAACATAAAGACA CAA-------------------------------------GAAACATGA--------AAA AGCA----GGGTAATA-------------TGAC--AACC--CCAA---A-AG-------- -------ATA----ACACCAGTTC-------------------AC-CAG---CAATGGAT ACATATC----------------AAGAAAAAGAAATCTCCAATTTACCAGAAAA------ ------AGAA------------TTCAGAAGGTTAGT-TATAAAGAAATTCAAGGAGGT-- --ACCAGAGGAAGGC--------------------------GAAGCCCAATAT-----AA GGAACTC----------------------------------------------------- --CAAAAAA--------------------------------------------------- -CATTAAA----------AGAAGATAAGGATGAAATATTCACCAGA-------------- -------------------------------------------ATAACCAATGTAGAGAA ----------GGAAATAGATAGCTTAATGAAAAAAAAATCAAAAC---------TACAA- GAAA----CACTG---------GACAC---ACTTATAGAAATGCAAAATACTTTGGAA-- ---AGCCTCAGCAATAGA----------------ATTG--------------------AA C--AAGT------------------AGAAGAAAG-AAT-TTCAG--AGCTCGAAGAC--- -AAAGTCTTTGAAA-T-----AATCCAATCAA---------ACAAAGACAAA---GAAAA AAGA---ATAAGAAAA-AA---------TGA---ACAAAGCCTCC--AAGAAAGCTGGG- ACTAT--------G---TTAAACG--ACCAAATCTACAA--A-TAATTGG--TGTT---- ----------CCTGAGG---ATGATGAGAGATTTCTGAAAGGTTTGG---------AAAA CATATTTGAGGA-----GGGAATAATGGAG--GAAAACTTCCCTAGCCT----------- ---------AGCAAGAGACCT--AATC--ATTCAAATAC-----AGGAAGCACAGAGA-A CACCAGGAA------------AATACAT-CTC--------------AAAAAGATCATCAC C-------T---------------------AGGCACATTATCATCAGATT------ATC- CAAAGTTCAAA---TGAAGG--AAAAAATCT----------------------------- -------------TAAGAGC--AGTGAGAGA---GAAGCATCAGGT-------------- -----------AAC---CTATAAAGG-AAAACCCA--------------TCAGACT--AA CAGCAGATTTC-----TCAGCAGAA--ACCCTA-CAAGC------CAG-AAGAGATTG-- -----------GGG-CCCTATA-T-------TCAATA--TCCT-------------CAAA GAAAA---------------CAATTT--TCA--GCCAAGAA--------TTT---TATAT CCA-----------GCAAAACTAAGC-----TTCAT-AAATGA-------AG-------- ------------------------G-AGAAATAAAGTCTTTCCCAGAAAAGC-CGAATCT GAGGGA-ATTCATCACCACTAGTC---CCAC------AAGAA------------------ --------------------CTGCTCAAGGA----------------------------- -----------------------------------AGCCC---------TAACTTGGAAG TGA----------------------------------------------------AAAGA AACA---------------ACCGACA---------------------------------- -------------------------------TTCACCATTATG----------------- ------------------------------------GAAACAC----------------- --------ACAAAAGTAGAAACAATTCCCAACTCATAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ATAA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GC-------- --------------------CTATAAGAACC----------------------------- --------------------------------------------------GAGACTTCCT TGACAT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAAAGGATATTTC--------------AA---ATGAATG ------------------------------------------------------------ ------------------------------------------------------------ -------------CAA-------------------------------------------- ------------------TGGTA------------------------------------- ------------------------------------------------------------ --------------------CCTCACATC--TCAATAATAAC-ATTGAAT-------G-T AAAT--GGCCT--AAATTC---TCCAATT----------------AAAAGAC------AC AGAG--TGGCAG----AATG---------GAT-------AAAA---AAATACAGACCAA- ----TGAAATCGATCT-GCTGCCTT-CAGGAAACGCACCT-TACCC--ATAAAGACACAC A-TAGACTGAAAGTAAAGGGG---T------------GGAAA----A-TGATATTCCATG C--------------AAATGG------ATACC---------------------AAAAA-A AAGCAG--GAGT----CGCTATACTTATATC-AGACAAAACAAACTTTAAG-GC------ ----AACAAAGA---TAAAAAGAGAC-AAAG-AAGGTCAT------TATAT------AAT GGTAAA---GGGATCAATT------CAACAA---GAAG--------AT-ATAACAA-TCT TAA-----------------A----TATACATG---------CACCCAACACTGGAGCAC CCAG--ATT-TATAAAGCAAGTACTAATAGACCT--AA----AAAATGA---------GA TAGACCCCAAT------ACAATAATAGTTGGAGACTTCAACA----------------CC ACACT------GTCAGC-ATTGGACAGATCAT---------------------TTAGAC- -----AGAA-------------AATCAACAAAGAAACATAGGATTTAAAC-AGAATTTTG GA------CCAAATGG---ACTTAATAGACATGTACA--GA----ACATTTCATCAGACA GC---TGCGGAATACACAT------TTTTTTCATCAG-----CA--CAT-GGAAGTTTCT --C----CAAGATAGACCATATGTTAGGTCACAAAACAAG-------------------- -TCTCAACAAATGTAAAAAAA--TTAAAAT----------------TATATCAA------ -GCATCTTCTCA---GACCACAGTGGAA-TAAAACTAGAAATCAAT-------------- ----------------------------------------------ACTA--------AA --------------AGA-AATTTTCA---AAACCATACAA----ATACATAGAAA--T-T AAATAAAATG-CTCCTGAA---TG-ACCAGTG--GGTCAATAATGA--AAT--T-AAGAA GGAAATT---------------TAAAAATTTCTT---GAAAC------------------ ------CAATGACAATAG-AAA------------CACAAC--ATATCAAAACCTC-TGG- GA-----TACAGCAAAAGCAGTA-----------------------------CTCAGAGG TAAG--TTTATAGCTCTA----AATGC----CTACAAAAGAAAGG---AGGAAAAAGTT- --CAAATTGAC-AATCTAA-TGTCACATCTT---AAAGAAC--TAGAAAAGC------AA GA-----ACAAACCAAAT-------------CCAAAAT--TAGTAGAA-GGAAAGAAATA ACA---AAGATCAGA-------------------GCAGAAATA---AA-T-GAAATTGAA ACAAA------AA------------------------------------AAA-CAA---T ACAAAAAATC-A---------ATG----AAACAA-AAAGGTG------GTTTTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATTGACAGACCA---CTAG CAA------GATTAA--CAA------------AGAAA------------------AAAAG A---AAGA-ATAATC-----------------AAATAAA--------TATAA-----TC- ---------AAA-AATCAAA--AA----------GGAGA---CATTACAACTGATACC-A CA-GAAATA--CAAAGGAT-TATTAG---------AGACTACT--ATGAA---------- -----------CAA---CTATACACAAATAA---ATTAGAAAATCTAG---AAGAAAT-- GGATAAATTCCT----------GGACAAA---------TAC-----AACCTACCA----- -AGATTAAATCA---TGAAGAAATAGAAACCCTGAAC----------------------- AGATC------------AA-TAACAAGTAATGAGATTGAAG-C---------AGTAAT-- -TAAAAACCTTCC------AACAAAGAAAAG---CCCAGGACC--TGATGG--------- ------------ATTCACA-GCAA--AA-------------------TACTC-------- ----TCAAACATTT---AAAGAA-GAGCTAG--TA-CCAATC----------CTTCTCAA ACTATT----CT---AAAAAATAGAG------AAAGAG-GG-----------AATCCTCC CTAACTCATTCT-----ATAAGGCT-----AGCAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGAT AAA---------------------GAC---ATAACAAAAAA------AAACTAT------ -------------A-GACCAATAT---CCC----TGATGAACATTGAT------------ ------------GCAAAAATCC-TTA--------------------A----CAAAATACT AGC-AAACTG------------------AA--TC--------------CA--GCA----- --------ACACATC---------AAAAAGATTATTCA--CCATGAT------------C AAG---TGGGA-TT----------CATCCCA------------GG--GATGCAAGGATGG -T----------------------TC-AAC-----ATACGC--AAATCAATAAA--CGTG ---ATATAGCACAT------AAACAG----AATGAAGAACAAAAAT---CATATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTTGACAA---AATTCAACATCCCTT- ---------------TATGA---------T---ACTAA------------------AAAC TA---------------------------------AAAA--------------------- ------ATCTATTTAT-GACACA--------CCCATAGC-----------CAACAT--AA TTCTGAATAATCA-----AAA-ACTGGAAGC----ATTC---CCT----CT--AAGAACT GGAACA----AGACAAGG-ATGC--CCACTG----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------CAG-AC------AAGAG---AAAGA --AATAAAGGGCATCCCAATAGGA---GAAAAG------GAAGTCAAA--T--------- ------TATCCCTG-TT--T---GCAGA------TAATAT------GATTTTATATTTA- -GAAAACC--CTAAAGA---CTCCACCA---------A---------------AA--AAC TCTTAAAACT---------GA--TAAACAAATTCAGCAAAG--TTT-----CAGGATAC- --AA-------------------------------AATTAA-------------CGT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCATTTC--TA-TACACCAAT---------------AGTGAACAAA-----CAG A------------------GAACCAAATC-A------AAAGCAAACCCATTTTTAAAAGC GCTACAAATGTA----------AATAAAATA---------ATA------TACCTAGGAAT AAACCT--------TA--C-CAAGGAAGTG---A---AAGACCTCT---ACAA-GGAGAA CTACAGAACAC------TGGTG-AAAAAAATAA-GA------------GAGG-------- ------------ATAC--AAAC--AAT---TGGA---AA--GACAT---------CCCA- --TGCTC------ATG-GATAGGAAAAATC-A---A---TATT--------------G-- GAAAAATG-----------------------------------------ACCAT--ACTG CCA-AA--AGTAATCTATA-------------------GA---TTCAATGTA---ATC-- ------C-CCATCAAAAT--A---------------------CCAAGA-CC---TTTCTT ------------------------------------------CACAGAATTTG------- ----------------------AAAAAACAGT------TTTAAAA-TCTACATATGGAAC CA------AAAAAAGAGCCC---TC--ATTGCCAAAGCAATACTAAGCA---AAAA--GA ACA---AATC--T-------GGA--GGCATCAC----CTACCTTACTTTAAAAC----TA TACTTA------------------------AAA---AACTTAGAT-AACAAA---AACGC G----------------TGGTACTGG--TA------------T---AAAAATAGATA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAT-- -CCAT----------------ATA-------TGTACAG----CCAACT--GATTTTT--- GACAAA--GCCAACAAAAACATTA--A-------------------GTAGG--GA---AA GG------------ATGCCCTTTT--GAGCAAACGA---------------TGCTG---- ------G-GATAAT--TGG-CTGGCCA---------------CATGTAGGGATATGCATA TGCAGAAA-GAACAGGATCCT---CATCT-----------CTCACT--TTA--T---ACA AAAA-TCAACT-CAAGAGGGATTAATAATAAAGAC---TTATATCTA--AGACCTGAAAC TAT------------------------AAAAGTTCTAGAA---------------AAGAA AACCATT------G------------------G-AAAACCCCTTGTAGACATTG--GCT- -----TAGTCAAGGATT-----TCACGAGCAA-GAACCCA---AAAGCAAATGCAAT--- --AAAAACA---AA----GAT---AAATAGC-TGGGAC----------TTAATT-AA--- ACTAAAGA-----G------------CTT-TTGCA-------CG--------------GT -AAAAGGAACAGT-------------CAGCAGAGTAAACAG------------------- ------A-------------TACCCT------ACAGAA--T-GGGAG---AAAATCTTC- --ACAATCTATACAT--------CT-------GACAAAGGAC--------TA--ATATC- ---CAGAATCTACCAC-AAAGACTTGA---ACAACCTCAAA--TCAGT------------ ---AAG--------------AA--AAAAA--------AATCCCA-TCAA---AAAGTGGG C--TAA---------GGA--TATGA---AT---AGACAGTT------------------- -----CTCAAAAGAA--------GATATAC---AA-ATGGCCAAC--AAACA--TGAAAA AAT----------GCTCAA-ATCTCTA-ATGGTCA------------------------- -----GGGA-AATGGAAA-----------------TC-AAAACCACA-------AT---- ----GT---AATACCA---------CCTT----ACTCCTGCAAGAATGGCCGTAATAAAA A--AAAAAAA-----TCAACAA-----ACAGTA-GATG--T------------------- ------TGGC-ATGGATGTG----------GTGAA------------------------- ------------CAGGGAATGAA----ACATTTCTGG--TGGG----------------- ----------AATGT--A-------------AACT---AGTGC----AGCCACTATGG-- ------AAAACAGTG--TGGAG--A-CTCCTT--AAAGAACTAAAA--GTAGAGCTACC- -ATTT---GA--TCCAGCAATCCCA---------------------CTACTTGG-TATC- --------------TA-CCCAGAGGAA------------AAGAAATCA----T------- --------------TATACGAA--GAAGATACTTGC---------ACACG----CATGTT TGTA--GCAGCACAGTTCACAA-TTGCAAAATCAT--G--GG--ACCA--ACCCAA---A TG-CCATCA---ATCAATGAA---AGTGGATAAAG--AAAC----TA------------- -----TAGTA-------------------------------------------------- ------------------------TATTT----ATACAATGGAATAC-----TAAAGTTG GCCATAA----AA----------------------AGAAATGAATTAACATCATTT---- ------------------------------------------------------------ --------GCAGTGACCTGGATGAGA-C---TGGAGACTATTATTCTAAGTGA------- ------------------------------------------------AGTAACTCAGGA ATGG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAACAT-CG-------- ---TAT---GTTCTCACTGAT----------ATGTGGGAGCGGAATATCTCTATATATAC TATGGAGTGATATTCTTCAGGATATATGTTTGTTGAGTGAAAAAAAGCGAGTAGGAAAGA GTTGTTATTTCATACTACCATTCATCTAAAAGATGAAAGAAAGAAGATGGATGTGTTAAT ATACAGAAAAATTTGCTTATATTTATAAAAAATCAAAGAAAAAATAAACCATAAAATTTT TTTAAATGATTACCTATAGAGGAAGCCAGAGGGAATAGAGTGGAGGGGAAGGGGATAAAA GCTAGACTTCTTTGAATATATCTTGTTATGTAGAATTTGACTTTGGAACCATGAAAATAT TTTACATAATTATAAAACAAAATTAAACAAATTTAAAAAAGCAATCCCTAAAAATAGAAA TAAAATAAAACAAATGAACCTAACTATGTATCCAGTTGGTGGTATAACCACACAGAGAGG AACTATTCCAAGTGACTTTAAAGCACAGTAATTTGAACTGTATATCCCTAGTGGGATATA TCCTAAGGACAAA---------AACAACTACCTGAAAAAACAAATTCTAAACTGGTTTCA GTAATCATATTGTTGGTGGTAGTGTTGGTATTGTTATTCTGAGACTGTTGTGTGTGTATT GTGGGATAAAGTAAATGAGTAATTATGTTGGTGTTATTGAGAACTGGGACTTTTAGTGTG GGTGAAAGGAGATACAGATGTAAGATAGATGAGGTTAAG--------TAAAAACCCTGTA GTCCTGAATTTGAATTGGAAGTATCAGTATGAACTCATGAAGTATATATATAAATTTATG TATTTAAATATATATATATCTATTTCCTAGCTCTGTCCACTGAAAAGGCCTAGAAACAAT GACCAACCCAGTAGCAATGAGCATCCCTAGCACCCAGATTGTAGTCTCTAAATACCATTT CCCACTAAAAGAAACCAGGGCTCCTTGGAGAAATGGCTGATTCCAGGTCTGGGGCAGG-- -------------------------------------------------AAATGTACAAG ATGAGCCTGGAACATCTTGTCATACCAGAAAGCAAGGACGCTATCAAAGAACTACTAGGG TCATGTCAAAAGGACTCAGGAGCCAACTTGAAGAGGCTCCCACTGGCCAAAGATGGGAAA ATTTGAGCATCAATAAGGATAATAACTGCAATGGATTGAAACACATCAAATATGTTTAAA TCCATGAGTTCATAATAATACAAAAAAACACTAATTGGTCACTTTTGGAGGATGCTAGGG AACCAACTCATTATTTTGAAAACTGGTAAAGCATT------------------------- ---------------------------------TTTAAATGGATA--CTAAAGGGAAAGA ATCAAGCATTTATCCTGCCTTTCCTATATGAACTATTCCACCAGGTAACCAAATAGTTGA TGAGAAGAAGTTTCTCTTTATAGAAGTATTCCAGCTAATAAATGAAAAAAGAATCATAGA ATATTAGTATATCACCATTTTGCAACCCCTAATGAATTAATGGATCTAGGCAT------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------TGATCATCAATGGCTGCTAACATCACAAAAAGAGAGACAAC CAGATATTATGTGCCTCCTGATGGAAGAACACAACACCACCTATGAAGTAGTCTTGCCAA AAAAATTAAACCTGAATCTGATCAAGCCTCTAGATCCAACTACCAATTTACAGGAAATAC AGAGGACAGAGGAACATGTTAAACA----------------------------------- -ACACCAT-GGGGATGCAATCAGCAAAATCCAGACTGTGGGGAATTCTACAGGACAAATG ACCCAGTTTCTTCAACAAATAAATTGC-----------------AAGGAAAAGAAAGAGA TGGAGGGAGAGAGAGAGAATCTATAGATTAAAAGAGACTTAAAAGACATGAACAACCCCA ATATATGGACCTTATTTGGATCATGATTCAAGAAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TAAATTAAAAAATTGAGAAAAATTGCATTGACATTT--- ------------------------------------------------------------ -------------------------------------ACGGGATATTTGGTGATATTAAC ACTGATGCTTTGGTGATATTAGAGAAAAATTATTATTATTTTTTAGATGTGATAATGGTA TTGTGGTTATATTTTTTTTTTAAAAAAATCTTATCTTTTAGAAATTCATACTGAAATATT TAAGGATGAAATGATATGATGTCTGGGATTTGCTTCAAAATAATATGGGGAGGGGAGGAA AGGATGAGTGGGGATATAGATGAAACAAGATTGGCCATGCATTGATAATTGTTGAAGCTG GGTAATGGGTATATGGGGGTTCATTATACTGTTCTCTCTACTTTTGTATATGTT--TGAA ATTTTTCATAATAAAAATTTAAAAA----------------------------------- ------ >L1ME3CZ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --A--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TGAGAAGAAA-----TCAGAAAAACAGTT CTG-------------------------------------GTAATATGA--------CAA AACA----AGGTTCTT-------------TAAC--ACCC--CCAA---A-AG-------- -------ATC----ATACCAGCTC-------------------AC-CAG---CAATGGAA TCAAACC----------------AAG---ACAAAATCTCTGAATTGACAGAAAA------ ------AAGA------ATAAGGTCAAGAAAGTCAAT-TATTAAGCTAATCAAGGAGCC-- --ACCAGAGAAAGTT--------------------------GAAGTCCAACTT-----AA AGAAATC----------------------------------------------------- --AAGAACA--------------------------------------------------- -TGATACA----------GGATATGAAGGGAAAATTCTTCAGTGAA-------------- -------------------------------------------ATAGACTGCATAAATAA ----------AAAA---------------CAATCAC------AAT---------TTCTG- GAAA----TCAAG---------GACAC---ACTTAGAGAAATGCAAAATCCTCTGGAA-- ---AGTCCCAGGAATAGA----------------ATCG--------------------AA C--AAGT------------------AGAAGAAAG-AAA-TTCAG--AGTTCGAAGAC--- -AAGGTCTTCAAAT-T-----AACTCTATCCA---------ACAAAGACAAA---GAAAA GAAAATAAGATTAAAA-CA---------TGA---ACAAAGCCTCC--AAGAAATCTGGG- ATTAT--------G---TTAAATG--ACCAAACCTAAGA--A-TAATCGG--TGTT---- ----------CCCGGGG---AAGAAGAGGAATCT---AAAAGTTTGG---------AAAA TATATTT---GG-----GGGAATAATCGAG--GAAAACTTCCCCAGCCT----------- ---------TGCCAGAGACTT--AGAC--ATCCAAATAC-----AAGAAGCACATAGA-A TACCTAGGA------------AATTCAA-CAC--------------AAATAGAACATTAT C-------T---------------------AGGCAAATAGTAATCGAGCT------ATC- TAAAGTCAAGA---ATAAAG--AAAGAATCT----------------------------- -------------TAAAAGC--TGCGAGACA---AAAGAACCAAGT-------------- -----------AAC---CTATAAAGG-AAAACTTA--------------TAAGATT--AA CAGCAGATTTC-----TCAGTAGAA--ACCCTA-CAAGC------TAG-AAAGGAGTG-- -----------GGA-TGCCATA-T-------TTTGTG--TGCT-------------GAAA CAAAA---------------AAATTA--TCA--GCCAAGAA--------TTT---TGTAT CCA-----------GCGAAACTAAGC-----TTCAA-ACATGA-------AA-------- ------------------------G-AAAAATACAGTCTTTTCCAGACAAAC-AAATGCG GAGAGA-ATTCGCCACTACCAGGC---CAGCACTAC-AAGAA------------------ --------------------CTGCTAAAAGG----------------------------- -----------------------------------AGCTC--------------TAAATC TTG----AATCTACATAAACACATCACAGTAAAAATGGAGAACACCCAAATACAAAGAGA AAAATTATAAAAGTATAAAAAAAAGAAAAA------------------------------ -------------------------------CTAATTACTCAAAAGGAACAATTAGACTG AC----------------------------------AGCATACTTGTGACCAAGAACAAG ATAACAAAGTTAAATGGTATAAAATTGCAAAAGTAACA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AATTAATTTTATTTTGGTTTAGAATTGTAGGCTAAATTACCATACAATAAT GAAATAAAAG-------------------------------------------------- --------TATTCTGAAACCACGGAGAAATGAAGCTCTAAGTTTTTAACTCCTTTGCCTC AACTTGTCCAACGAAGAACTAGCTGGAAAAGAAAAAGAAATTGCCAGAAGCAATGGAGAA GAAAAAAATTACTCAACACACGCCAGACCAAACAGATGCTCACCGTTTGAATCAATGATA ATGATGATAATACATGGGTCAACAAAAACAACATGTAACTGAAACTATAGTCAACAATTA TCTGCAAACTTGTGCGATAGTGATAAGAATTAAAGCAAATCTCAAGCCAAACTACTGTCC AAGACGAAGACA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GATTGAGTAA TGACTAGTCTGACCTCCTTGCAATGAAATT-------------------------TATAG CTTTAAATCAAGTAAAAGGAAG----------------------------AAAAGAATAA AGAAAATTAAATCAATTCAATACCAAGTAGAAAAGTGTGGGTAAAGAA------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AAAGAGAAAA AAAATGCATAGTACACACCAGATAGATGCATAATACAAACAAATCAAAAAATCATAGGAA CAACAATAAATATTAAAGTACTAAACTCAC------------------------------ ---------------------CAGTTAAAAAACAAATTCTCAAATTGGAA---AAGATTA GAAAA------------------------------------------------------- ---------------------------------------------TCCAGCTAGAGAGAC TTGTAAAATATTACAGCATAGAAGAGT--------------------------------- ------------------TGTTAAAAAAAGAAAATAACTAAACAAGA------------- ------------------------------------------------------------ --------------------AAAAACCTA--TCAATACTAAC-ATTGAAT-------G-T AAAT--GGACT--AAATTC---TTCAGTT----------------AAAAGAT------AC AGAA--TGGCAG----AATG---------GAT-------AAGAATTAACCAAGACCCAA- ---CTA-------TAT-GCTGCCTA-AAGAAAATTCACCT-AACAT--ATAAAGACTCAC A-TAAACTTAAGGTAAAGGGG---T------------GGAAA----A-AGATATTCCATG C--------------AAATGG------GCACC---------------------AAAAG-C GAGCAG--GAGT----AGCTATTCTTATATC-AGACAAAACAGACTTTAAA-GC------ ----AACAACAA---TTAAAAAAGAC-AAAG-AAGGACAT------TATAT------AAT GATAAA---AGGGCTAGTC------CAACAA---GAAA--------AT-ATCACAA-TCC TAA-----------------A----TATATATG---------CACCTAACACTGGAGCAC CCAA--ATA-TATAAAGCAAATATTAATAGACCT--AA----AGAGAGA---------GA TAGACCGCAAC------ACAATAATAGTGAGGGACTTCAACA----------------CT CTACT------TACAGC-ATTAGACAGATCAT---------------------CAAGAC- -----AGAA-------------AATCAATAAAGAAACAATGGACTTAAAT-TATAACCTG GA------ACAAATGG---ACTTAAAAGACATTCACA--GA----ACATTCCATCCAACA AC---TTCAGAATATACAT------TCTATTCATCAG-----CA--CAT-GGAACATTCT --C----CAAGATAAACCATATGTTAGGCCACAAAACAAG-------------------- -CCTTAATAAATTTAAGAAAA--TTGAAAT----------------CATATCAA------ -GTATTTTCTCA---AACCACAATGGAA-TAAAACTAGAAATCAAC-------------- ----------------------------------------------TCCA--------AA --------------AGA-AACCTTCA---AAACCATACAA----ATACATGAAAA--T-T AAATAACATG-CTCTTGAA---TG-ATCATTG--GGTCAAAAATAA--AAT--T-AAGAA GAAAATTAATGAATGGAAATGTAAAAAATTACTT---GAAAC------------------ ------AAATGAAAATGG-AAG------------CACAAC--ATACCAAAACTTA-TGG- GA-----TACAGCAAAAGTAGTA-----------------------------CTAAGAGG AAAT--TTTATAGCAATA----AATGT----CTACATCAAAAAAA---GTGAAAGAGTT- --CAAATAAAC-AATCTAA-GGTTGCACCTC---AAGGAAC--TAGAAAAAC------AA AA-----ACAAACCAAAC-------------CCAAACT--CAGCAGAA-GAAAAGAAATA GCA---AAGATCAGA-------------------GCAGAAATA---AA-T-AAAATTGAA ACAAAAAACACAA------------------------------------CAA-AAA---T AGAAAAGATA-A---------ATG----AAACAA-AAAGTTG------GTTCTTTGAAAA GATAAA------------------------------------------------------ --------------------------------TAA-----AATAAATAAACCA---TTAG CTA------GATTAA--CCA------------AGAAA------------------AGAAG A---GAAA-AAATCC-----------------AAATAAA--------TAAAA-----TT- ---------AGA-AATAAAA--AA----------GGAGA---TATTACAACTGATACC-A CA-GAAATA--CAAAGGAT-CATTAA---------AGACTATT--ATGAA---------- -----------CAC---CTTTATGCAAATAA---ATTAGAAAACCTAG---AAGAAAT-- GGATAAATTCCT----------GGACACA---------TAC-----AACCTACCA----- -AGATTGAATCA---TGAAGAAATAGAAAACCTGAAT----------------------- AGACC------------AA-TAACAAGTAACAAGATAGAAA-T---------AGTAAT-- -AAAAAAATTCCC------AACAAAGAAAG----CCCAGGACC--AAGTGG--------- ------------ATTCACT-GCTG--AA-------------------TTCTA-------- ----CCAAACATTT---AAAGAA-AAATTGGAATA-CCACTC----------CTTCTCAA ACTATT----CC----AAAAATAGAG------GAGGAA-GG-----------AATACTTC CAAACTCATTCT-----ATGAAGCC-----AGTAT---TACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGAA AAA---------------------GAC---ACAACCAAAAAAGTAGAAAACTAT------ -------------A-GACCAATAT---CTC----TGATGAATATTGAT------------ ------------GCTAAAATCC-TCA--------------------A----CAAAATACT AGC-TAATCA------------------AA--TT--------------CA--ACA----- --------ATACCTT---------AAAAAGATAATTCA--TCATGAT------------C AAG---TGGGA-TT----------TATCCCA------------GG--GATGCAAGGATGG -T----------------------TT-AAC-----ATATAC--AAATCAATAAA--TGTG ---ATACATCACAT------AAACAG----AATGAAAAACAAAAAT---CATATGA---- -TCATTTCAATA---GATGC---AGAAAAAGCATTTGATAA---AATTCAACATCCATT- ---------------CATGA---------T---A--AA-----AACTCTCAAC---AAAA TAGGCATAGAAGGAACAT-----GCCTCAACATAATAAA--------------------- ------GGGCATCTAT-GACAAA--------CCCACAGC-----------TAATAT--CA TATTGAATAAGGA-----AAA-ACTGAAAGC----CTTT---CCT----CT--TAGAACC AGAACA----AGAAAAGG-ATGC--CCCCTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCGCTGTTATTC---AACATAAT ACT---GGAAGTCCTAGCCAGAGCAAT--------TAG-AC------AAGAG---AAAGA --AATAAAGGGCATCCAAATTGGA---AAGGAA------GAAGTCAAA--T--------- ------TGTCCCTA-TT--T---GCAGA------CGATAT------GATCGTATATATA- -GAAAACC--CTAAAAA---CTCAACAA---------A---------------AA--AGT TCCTAGATCT---------AA--TAAATGAATTCATTAAAG--TTT-----CAGGATAT- --AA-------------------------------AATAAA-------------TGT--- ACAAAAAT----TAGT-------------------------------------------- -----AGTACTTC--TA-TACACCAAC---------------AGTGAACAAT-----CTG A------------------AAATCAAATC-AAG----AACACAATCCCATTTACAATAGC TGCA------------------AAAAATATA---------AAA---AAAATAGTAGAAAT ATACCT--------AA--C-CAAGGAGGCG---A---AAGATCTCT---ACAA-GGAAAA CTACAAAATAC------TGCTG-AAATAAATTA-AA------------GATG-------- ------------ACAC--AAAT--AAA---TGGA---AA--GATAT---------CCCA- --TGTTC------ATG-GATTGGTAGAATC-A---A---TACT--------------G-- TCAAAATG-----------------------------------------ACCAT--ACTG CCA-AA--AGCAATCTACA-------------------AA---TTCAATGCA---ATC-- ------C-CCATCAAAAT--A---------------------CCAACA-TC---ATTCTT ------------------------------------------CACAGAATTAG------- -------------------AAAAAAAAACAAT------TCTAAAA---TTCATATGGAAC C-------AAAAAAGAGCCC---AC--ATAGCCAAAGCAAGACTAAGCA---AAAA--GA ACA---AACC--T-------GGA--GGCATCACA---CTACCTGATTTCAAACT-----A TACTAT-------------------------AA---GGCCATAGT-CACCAA---AAC-A GCA--------------TGGGACCTG--TA------------T---AAAAATAAGCA--- ---CGAAGAC--CAACTATGG-AACAGAATGGAGAACCC------AG---AAATAAAC-- -CCAA----------------ATA-------CTTACAG----CCAACT--GATCTTC--- AACAAA--GCAAACAAAAACATAA--A-------------------GTGGG--AA---AA GA------------ACACCCTATT--CAACAAATGG---------------TGCTG---- ------G-GATAAT--TGG-CTAGCCA---------------CATGT-AGGAGAAATATG ---------AAACTGGATCCTTTACATCT-----------CTCACC--TTA--T---ACA AAAA-TCAACT-CAAGATGG---AT---CAAGGAC---TTAAATCTA--AGACCTGAAAC TAT------------------------AAAAATTCTGGAA---------------GATAA ---CATT-------------------------GGAAAAACCCTTCTAGACATTG--GCTT AGGCTTAGGCAAGGATT-----TCATGACCAA-GAACACA---AAAGCAAATGCAAT--- --AAAAACA---AA----GAT---AAATAGC-TGGGACAAT-------TTAATT-AA--- ACTAAAGA-----G------------CTT-TTGCA-------CG--------------GC -AAAAGGAACAGT-------------CAGCAGAGTAAACAC------------------- ------A-------------CAACCC------ACAGAG--T-GGGAG---AAAATCTTT- --ACAATCTATACAC--------CT-------GACAAAGGAC--------TA--ATATC- ---CAGAATCTACAAT-GA--ACTCAA---ACA------AAACTTAATTAGCAAAAAACA AAAACAAACAAATCAAAACAAAATAAAAAACCTAAACAATCCCA-TCAA---AAAGTGGA C--TAA---------CAA--CATGA---AT---AGACAGTT------------------- -----CTCAAAAGAA--------GATATAC---AA-ATGGCCAAC--AAACATATGAAAA AT-----------GCTCACCATCACTATATGATCA------------------------- -----GGGA-AATCCAAA-----------------TC-AAAACCACA-------AT---- ----GC---GATACTG---------CCTC----ACTCTTGCAAGAATGTCCATAAT---C AAAAAAA--------TTAAAAA-----ATACGTAGATG--T------------------- ------TGGC-ATGGATGCT----------GTGAA------------------------- ------------CAGGGAACACTTCT-ACACTGCTTG--TAGG----------------- ----------AATGTATT-------------AACT---AGTAC----AGCCACTATAG-- ------AAAACAGTG--TGGAA--A-TTCCTCATAAAGAACTAAAA--GTAGAACTACC- -ATTT---GA--TCCAGCAATCCCA---------------------CTACTGGG-TATC- --------------TA-CCCAGAGGAA------------AATAAGTCA----T------- --------------TATTCGAA--AAAGATACTTGC---------ACACA----CATGTT TATA--GCAGCACAATTCACAAGTTGCAAAATCGT--GAAGA--ACCA--AACTAATCCG TGTCCATCA---ATCAATG-----AGTGGATAAAG--AAAC----TG------------- -----TGG---------------------------------------------------- ------------------------GATAC----GTACAGTCTGACAA-----C--ATTTA TGTACAATTTGAA----------------------AAGTATGAAACGATGCAATATTCT- ------------------------------------------------------------ --------GTATTTTTATGGGT------------------TCATATGCAGTAA------- --------------------------------------------AAGTGTAAAACCTAGA TTGG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAATTACATA--------------------------CCAAATTCATG-------- ----ATAGTGGTTGCCTCTGG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------GCAAAAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GGT--------GGGGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GGTATTGGGA-----------------------AGGAGAACAAAGGGG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ACTTCATATAGG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TCAGTAACATT------------- ------------------------------------------------------------ ------------------------------------------------------------ -ATATAATAATATATTT------------------------------------------- -----------------------------------------TTAAATAAA---------- ------------------------AGATCTGAAGCAAATATGGCAAAGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAATATTAACATTTGTTAATTCTAGGAGACAGGTAC--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ATGGGTGTTTATAATATTCTTCTTGCATTTTTCTGTATCTATAAC TTTTTTTCTAAATAATAAAATTAAAAGA-------------------------------- ------ >L1PB2 ------------------------------------------------------------ ------------------------------------------------------------ -------------------GGAAG-----------------ATGGCAGATAGGAGACAGG GCTAACGTG---------------------------CAGCTCCCACTTGG---------- -------------------------------------------ACGAACAGAACAGTGTG TGGAGA-----------CTCACACTGTGAACTTTTGCTCCAAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AACCACCGCAG-------GAACGT ACCAGGAAAACCAAAAGAATTCACAGATCCTTTG---------AAAGAAGCGGCATGCCA CTGCAAACTTCACA---------------------------------------------- -----------------------------------------------------AGACAGG TGAAAAACTGTGAGTTCCCAAAGTGTGAGAGGGG-----GA---AAACCTGCCTCCGAAC ACACATCCCCAC----------------------------------------TGGGGAAT CTGAAAATCCAGATCACGAGAGAAGGATTTAACCTTACCTAGAGCTGAAATGGAT----- ---------------------------------------------TTAGGGAGCTGCGTG AAATATAAAAGTAGAAGCAGCAGCAGGAAGAGCCCTGCAGGCACTCCCAGTCTCCAGCTT GA---------------------------------------------------------- ------------------------------------------------------------ -------------------------------GCCCAGGGAAGCCATTCCTGACTTTATCT CACAGGGGCCCTTGGGGAAGGCAGCCAGCAGAACGGGGGAGGGGTCATAGGGTGAAGGAA GCTTCCAACTAAACTT-------------------------------------------- -------------------------------------TGTGATAATTTTGACTGGGCACA AATTTTCTTGAGCAGAATCCAGGGGGTAAACGGG-----------AGCTGCTGCAGATAC GAGTGCTGCCTGCAGAAGA----------------------------------------- ----GGCGCTGCCTG------------TCTTGTGGGCAGACGGGGAGGGGTGAGGCCTGA AA-----GCCATGCTTGCTTTCTCAGCGGGGAAGCTTATGG------------------- ------------------------------------------------------------ ----CCTGGGGCAGGTTCGAG--------------------------------------- ------------------------------------------------------------ ----------------------------------------TTCCGTGCGCAGGCTGCCTG GATCTAAACTCGGCACTGTTAGTGGGGCACTGCAGGAGCGAGACCAGCCTCACCAACTGC GTGGGAGCTGGGTGAGG------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------CCTTTCGCTA-------CTGGCTGTCCCCCACTTCCCTGG CGAACTATATTACACAGCAGAGGCAGCC-------------------------------- ------------------------------------------------------------ -------------------------------ATAATCCCCTCTGGAACATAACCCCATTG GCCTG-AGAACCACCCCCTTCCCCCCATCCCCCACAGTGGCCAT---------------- ------------------------------------------------------------ --------------------------------------------GGCAAGCCCCGCCCAA GGAG------AGTCTGAGCTCAGACCCGCCTAACCCTGCCCCCACCTGATGGTT------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TTTCTCTACCTGCCCTGGTAG CCGAACACAAAAGA---------------------------------------------- ------------------------------------------------------------ --------------------CATAAACTCTTGGGAGCTTTATGGCCCTGCCCATCACCTG AGAAACCAGAATACTTCCCCTGGCCAACTTAGGGCAAGCT-------------------- ----TATATCCCCCTGCTACTACCGCAGCTGGTGC----TCTCTTGAAAGCGCCACCTCC TGGCTGGAGGCCAACCAACTCAGGCCATTACAGCAACT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------CATGACAGAATAACCCTGCTCCCAGGAAGGAGAAAAC AACAGCTAATTCCACTGCCTGCAACATCCTGGCTAACCAGAGGTCCTGAGTCTGTCCACG TGACAACTTCACTGCTAGCATAACCAGCATTTGAGAAAGCCAGCACA------------- ---------------CTAAACATATCTACAACCAAGGACTCTCACAGAGTCTACTTCACT CCCCTGCC--------------------------------------ACCTCCACCAGAGC AGGTGCTGGTATCCACGGCTGGGAGACCTGAAGACGGATCACATCACAGGACTCTTTGCA GACATTCCCCAGCACCAGCCCAGAGCCTGGTAGCCCCGCTGGGTGGCTAGACCCAGAAGA GCAATAACAATCACTGCAGTCTGGCTCTCAGGAAGCCCCATCCCTAGGGGAAGGGGGAGA GCACCACATCAAGGGAT-----------------------------------------CA CCCCGTGG-----------------------GACAAAAGAA-----TCTGAACAGCAGGC CTTGAGTTCCAGATTTTTCCACTGAAATAGTCTACCCAA-GTAATATGA--------CAA AACA----AGGTTCTA-------------TAAA--CCCC--CCAA---A-AG-------- -------TCC----ACACTAGCTC-------------------CC-CAG---CAATGGAT CCAAACC----------------AAG---AAGAAATCTCTGAATTGCCAGATAA------ ------AGAA------------TTCAGAAGGTTGAT-TATTAAGCTACTCAAGGAGAT-- --ACCAGAGAAAGGT--------------------------GAAAACCAACTT-----AA AGAAATT----------------------------------------------------- --AAAAAAA--------------------------------------------------- -CAATACA----------GGATATTGATGAAAAATTCTCCAGAGAA-------------- -------------------------------------------ATAGATATCATAAAGAA ----------AAAA---------------CAATCAC------AAC---------TTCTG- GAAA----TGAAA---------GACAC---ACTTAGAGAAATACAAAATGCACTGGAA-- ---AGTTTCAACAATAGA----------------CTAG--------------------AA C--AAGT------------------AGAAGAAAG-AAC-TTCAG--AGCTCAAAGAC--- -AAGGCTTTCAAAT-T-----AACCCAATCAG---------ACAAAGACAAA---GAAAA AAGA---ATTTTAAAA-AA---------TGA---ACAAAGCCTCC--AAGAAATTTGGG- ATTAT--------G---TTAAATG--GCCAAACCTAAGA--A-TAATTGG--TGTT---- ----------CCTGAGG---AAGAAGAGAAATCT---AAAAGTTTGG---------AAAA CTTATTT---GA-----GGGAATAATTGAG--GAAAACTTCCCTGGCCT----------- ---------TGCTAGAGATCT--AGAC--ATCCAAATAC-----AAGAAGCTCAAAGA-A CACCTGGGA------------AATTCAT-CAC--------------AAAAAGATCATCAC C-------T---------------------AGGCACATAGTCATCAGGTT------ATC- TAAAGTCAAGA---CAAAGG--AAAGAATCT----------------------------- -------------TAAGAGC--TGTGAGACA---AAAGCATCAGGT-------------- -----------AAC---CTATAAAGG-AAAACCTA--------------TCAGATT--AA CAGCAGATTTC-----TCAGCAGAA--ACCTTA-CAAGC------CAG-AAGGGATTG-- -----------GGG-TCCTATC-T-------TTAGCC--TCCT-------------CAAA CAAAA---------------TAATTG--TCA--GCCAAGAA--------TTT---TGTAT CCA-----------GCAAAACTAAGC-----TTCAT-AAATGA-------AG-------- ------------------------G-AGAGATAAAGTCTTTTTCAGACAAAC-AAATGCT GAGAGA-ATTTACCACTACCAAGC---CAGCACTAC-AAGAA------------------ --------------------ATGCTAAAAGG----------------------------- -----------------------------------AGTTC--------------TAAATC TTG----------------------------------------------------AAAAC AAAACCTC---------------------------------------------------- ------------------------------------------------------------ ------------------------------------AAAATAC----------------- --------ACCAAAATAGAACCTCCTTAAAGCATAAATC--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TCACAGGGCC-------------------------TATAA A-------------------------------------------------ACAATAACAC AATGAAAAAT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAAAAAAAACAAG-------------------GTATTTA GGCAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------CAACTAG----------------------- ------------------------------------------------------------ --------------------CATGACATC--TCAATACTAAC-ATTGAAT-------G-T AAAT--GGCCT--AAATGC---TCCACTT----------------AAAAGAT------AC AGAA--TGGCAG----AATG---------GAT-------AAAA---ATCCACCAACCAA- ---GTA-------TCT-GCTGTCTT-CAAGAGACTCACCT-AACAC--ATAAGGACTCAC A-TAAACTTAAGGTAAAGGGG---T------------GGAAA----A-AGATATTCCATG C--------------AAATGG------AAACC---------------------AAAAG-C GAGCAG--GAGT----AGCTATTCTTATATC-AGACAAAACAGACTTTAAA-GC------ ----AACAACAG---TTAAAAAAGAC-AAAG-AGGGACAT------TATAT------AAT GATAAA---AGGATTAGTC------CAACAG---GAAA--------AT-ATCACAA-TCC TAA-----------------A----TATATATG---------CACCTAACACTGGAGCTC CCAA--ATT-TATAAAACAATTACTACTAGACCT--AA----GAAATGA---------GA TAGATGGCAAC------ACAATAATAGTGGGGGACTTCAATA----------------CT CCACT------GACAGC-ACTAGACAGGTCAT---------------------CAAGAC- -----AGAA-------------AGTCAACAAAGAAACAATGGACTTAAAC-TATACCCTA GA------ACAAATGG---ACTTAACAGATATTTACA--GA----ACATTCTACCCAACA AC---TGCAGAATATACAT------TCTTTTCATCAG-----CA--CAT-GGAACATTCT --C----CAAGATAGACCATATGATAGGCCACAAAACAAG-------------------- -TCTCAATAAATTTAAGAAAA--TTAAAAT----------------TATATCAA------ -GTACCCTCTCA---GACCACAGTGGAA-TAAAACTGGAAATTAAC-------------- ----------------------------------------------TCCA--------AA --------------AGG-AACCCTCA---AAACTATACAA----ATACATGGAAA--T-T AAATAATCTG-CTCTTGAA---TG-ATCTTTG--GGTCAACAATGA--AAT--C-AAGAT GGAAATT---------------AAAAAATTCTTT---GAACT------------------ ------GAATGATAATAG-TGA------------CACAAC--TTATCAAAACCTC-TGG- GA-----TACAGCAAAAGCAGTG-----------------------------CTAAGAGG AAAG--TTCATAGCATTA----AATGC----CTACATCAAAAAGT---CTGAAAGAGCA- --CAAATAGAC-AATCTAA-GGTCACACCTC---AAGGAAC--TAGAGAAAC------AA GA-----ACAAACCAAAC-------------CCAAACC--CAGCAGAA-GAAAAGAAATA ACA---AAGATCAGA-------------------GCAGAACTA---AA-T-GAAATTGAA ACAAA------AA------------------------------------AAA-------T ACAAAAGATA-A---------ATG----AAACAA-AAAGCTG------GTTCTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATTGATAGACCA---TTAG CAA------GATTAA--CCA------------AGAAA------------------AGAAG A---GAGA-AGATCC-----------------AAATAAG--------CTCAA-----TT- ---------AGA-AACAAAA--TG----------GGAGA---TATTACAACTGATACC-A CA-GAAATA--CAAAAGAT-CATTCA---------AGGCTACT--ATGAA---------- -----------CAC---CTTTATGCACACAA---ACTAGAAAATCTAG---AGGAGAT-- GGATAAATTCCT----------GGAAATA---------TAC-----AACCCTCCT----- -AGATTAAATCA---GGAAGAAATAGAAACTCTGAAC----------------------- AGACC------------AA-TAACAAGTAGCAAGATTGAAA-C---------AGTAAT-- -TAAAAAATTGCC------AAAAAAAAAAAG---TCCAGGACC--AGATGG--------- ------------ATTCACA-GCTG--AA-------------------TTCTA-------- ----TCAGACATTC---AAAGAA-GAATTGG--TA-CCAATC----------TTACTGAA ACTATT----CC---AAAAGATAGAG------AAAGAG-GG-----------AATCCTCC CTAAATCATTCT-----ATGAAGCC-----AGTAT---CACCCTA-ATAC---------- ----------------------------------------C--AAAAC-------CAGGA AAG---------------------GAC---ATAACAAAAAA---AGAAAACTAC------ -------------A-GACCAATAT---CCC----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-TAACCA------------------AA--TC--------------CA--ACA----- --------GCATATC---------AAAAAGATAATACA--CCATGAT------------C AAG---TGGGT-TT----------CATACCA------------GG--GATGCAGGGATGG -T----------------------TT-AAC-----ATATGC--AAGTCAATAAA--TGTG ---ATACATCACAT------AAACAG----AATTAAAAACAAAAAT---CATATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTTGACAA---AATCCAGCATCCCTT- ---------------TATGA---------T---T--AA-----AACCCTCAGC---AAAA TTGGCATAGAAGGGACAT-----ACCTCAAGGTAATAAA--------------------- ------AGCCATCTAT-GACAAA--------CCCACAGC-----------CAACAT--TA TACTGAACGGGGA-----AAA-GTTGAAAGC----ATTC---CCC----CT--GAGAACT GGAACA----AGACAAGG-ATGC--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------CAG-AC------AAGAG---AAAGA --AATAAAGGGCATCCAAATCGGT---AAAGAG------GAAGTCAAA--C--------- ------TGTCACTG-TT--C---ACTGA------TGATAT------GATTGTATACCTA- -GAAAACC--CTAAAGA---CTCATCCA---------A---------------AA--AGC TCCTAGATCT---------GA--TAAATGAATTCAGTAAAG--TTT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- ACACAAAT----CAGT-------------------------------------------- -----AGCACTGC--TA-TACACCAAC---------------AATGACCAAG-----CTG A------------------GAATCAAATC-AAG----AACTCAACCCCTTTTACAACAGC TGCA------------------AAAAAAATA---------AAA------TACTTAGGAAT ATACCT--------AA--C-CAAGGAGGTG---A---AAGATCTCT---ACAA-GGAAAA CTACAAAACAC------TGCTG-AAAGAAATCA-TA------------GATG-------- ------------ACAC--AAAC--AAA---TGGA---AA--CACAT---------CCCA- --TGCTC------ATG-GATGGGTAGAATC-A---A---TATT--------------G-- TGAAAATG-----------------------------------------ACCAT--ACTG CCA-AA--AGCAATCTACA-------------------AA---TTCAATGCA---ATT-- ------C-CCATCAAAAT--A---------------------CCATCA-TC---ATTCTT ------------------------------------------CACAGAACTAG------- ----------------------AAAAAACAAT------CCTAAAA---TTCATATGGAAC C-------AAAAAAGAGCCC---AC--ATAGCCAAAGCAAGACTAAGCA---AAAA--GA ACA---AATC--T-------GGA--GGCATCACA---TTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTATAGT-TACCAA---AAC-A GCA--------------TGGTACTGG--TA------------T---AAAAATAGGCA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAG-- -CCAA----------------ATA-------CTTACAG----CCAACT--GATCTTT--- GACAAA--GCAAACAAAAACATAA--A-------------------GTGGG--GA---AA GG------------ACACCCTATT--CAACAAATGG---------------TGCTG---- ------G-GATAAT--TGG-CAAGCCA---------------CATGT-AGAAGA---ATG ---------AAACTGGATCCT---CATCT-----------CTCACC--TTA--T---ACA AAAA-TCAACT-CAAGATGG---AT---CAAAGAC---TTAAATCTA--AGACCTGAAAC CAT------------------------AAAAATTCTAGAA---------------GATAA ---CATC-------------------------AGAAAAACTCTTCTAGACATTG--GCT- -----TAGGCAAAGAGT-----TCATGACCAA-GAACCCA---AAAGCAAATGCAAC--- --AAAAACA---AA----AAT---AAATAGA-TGGGAC----------CTAATT-AA--- ACTAAAAA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAATAAT-------------CAGCAGAGTAAACAG------------------- ------A-------------CAACCC------ACAGAG--T-GGGAG---AAAATATTC- --ACAAACTATGCAT--------CC-------GACAAAGGAC--------TA--ATATC- ---CAGAATCTACAAG-GA--ACTCAA---ACA------AA--TCAGC------------ ---AAG--------------AAAAAAACA---AAT--AATCCCA-TCAA---AAAGTGGG C--AAA---------GGA--CATGA---AT---AGACAATT------------------- -----CTCAAAAGAA--------GATATAC---AA-ATGGCCAAC--AAACATATGAAAA AAT----------GCTCAACATCACTA-ATTATCA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------CCTT----ACTCCTGCAAGAATGGCCATAAT---T A--AAAAA-------TCAAAAA-----ATAATA-GATG--T------------------- ------TGGC-ATGAATGTG----------GTGAA------------------------- ------------AAGGGAACACTTTT-ACACTGCTGG--TGGG----------------- ----------AATGT--A-------------AACT---AGTAC----AACCACTATGG-- ------AAAACAGTA--TGGAG--A-TTCCTT--AAAGAACTAAAA--GTAGAACTACC- -ATTT---GA--TCCAGCAATCCCA---------------------CTACTGGG-TATC- --------------TA-CCCAGAGGAA------------AAGAAGTCA----T------- --------------TATATGAA--AAAGACACTTGC---------ACACA----CATGTT TATA--GCAGCACAATTCACAA-TTGCAAAATTAT--G--GA--ACCA--GCCTAA---A TGCCCATCA---ACCAATG-----AGTGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAT----ACACCATGGAATAC-----T--ACTCA GCCATAA----AA----------------------AGGAATGAAATAATGGCATTT---- ------------------------------------------------------------ --------GCAGCAACCTGGATGGAG-T---TGGAGACCATTATTCTAAGTGA------- ------------------------------------------------AGTAACTCAGGA ATGG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAATAT-CA-------- ---TAT---GTTCTCACTTAT----------AAGTGGGAGCC------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TAAGCTATGAGGATGCAAA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------GGCATA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------ATGATAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----AATGGAC-----------------------------------------------T TTG-------GGGACTCGGG--------------------GGGAAGGGTGGGAGGGGG-- -------------------------------------------------GT--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GAGGGATAAAAGACT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ACACATTGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----CAGTGTACACTGCTCGGGTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ATGGGTGCACCAAAATCTCAGAAATCACCACTA------------ ------------------------------------------------------------ ------------------------------------------------------------ -AAGAACTTATCCATGT------------------------------------------- --------------------------------------------AACCAA---------- -------------AAACCACCTGTTCCCCAAAAACTA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----TTGAAATAAAA-------------------------------------------- ------ >L1PB3 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AG-----------------ATGGCAGATTGGAGGCATT GCTAGCATG---------------------------CCTCTCCCACTTGGAAAGACAAAA TAGTGTGTAGAGATTCACACTGTGAACTTTTTTCCAAGAAGCAACGCAGGAACTTAACAG GAAAACTGAAAGAAACCACAGACTCTTTGAAAGAAGCAGTAGGCTGCAGCCTACACTGTG AGCCAGGCAAAAAACTGTGAGTCCCCAGAGTGTGAGAGGGGGAGAGACTGCCTTCAGGAT ACACACCCCCACCGGGGAACCTGAAAATCCAGGCCACAGGGGAAGGCCTTAACCCTACCC AGTGCTGGAACTGATTTAGGGAGCAGTGGG------GAATATAAAAGTAGGAGCAGCAGC GGGAAGAGCCTTGTGTGCACTCCCAGTCTCCAGC---------A-TGGACCGAGGGAAGC CATTCCTTATTCTACCTCACAGGGGACCTTGCGGAAGTCTGCCAGCTAACTCAGGCAGTG GTCACAGGTTGAGAGAAGCTCCCAACTGAAATTCATGATATAATCTCGAGTGGGGATAAA CTCCCTTGGCCAGAACCGGGGGGTGAGTGGGAAG-----TG---TGCTGCAGCCATGGGC ACAGGAGCTGGGCGCCCCGGCTTT----------------------------GCGGGTAG ACTGGGAGGGGCATGGCCTGAAAGCCATGGTTGCTGTCTCCGCCGGGAAGGCTTATGGCC TGGGGCAGTTTTGAGTTCTGAGTACAGGCTGCCTGGAACTTAGCTTGCTGCTGCTAGTGG AACACTGTGGGTGTGAGATCTGCCTTGCCAAGTGCGTGGGAGCTGGGTGGGGCTTACTGC CGCCTGCTACTCCCCACTCCCTGTGCAAACTCTTCTGTGCAGCAGAGGCAGCTATGCTCC TCTCTGGAACATTACCCCAGTGGCCTGAGAACCGCCCCCCGACCCCCACAGGGGCTGCTG CTTGCCCCGCATGTGGAGAGCCAGAGCGCAGACCTGCCTGACCC----AGCCCCCACCTG GCTTTGCCCCTCCACCCGCCCTGGTAGCTTAACACAAAGGACAGAAACTTTTGGGAGCTT TATGGCCCCGC------------------------------------------------- ------------------------------------------CCATTGCCTGAGAAACCA GAGTACCTCCCCTGGGTAACATAAGGCAAGCACAAATCCCACTGCTACTACCACAGCTGG TGCTCTTTTGCAAGCGCCACCTCCTGGCTGGAGG----------------------CCAA CCAACACAGTCCATT------------ATAGCATCT---GCAGGTAGAATAACA------ --------------CTGCACCCAGGAAGGAGAAAACTTGTG------------------- ------------------------------------------------------------ ----CGTGACCTCAGCTATCACCATTGCCTGCACCACGCT-------------------- ------------------------------------------------------------ -------------------GGCTAACCAGGAGGTCCTGAGTCTGTCCATGTGACCAGT-- ---------TCATTACTACTACAACTGGCATTTGAGAAAGCCAACACACTAAGGCTATTA ATAATCTATAAATCTAAGAAAATTTCTAAAGTCCATCTCACCCCCCTGCCACCCCCACCA GAGCTGGTGCTGGTACCCACTGCTGGGAGACTTGAGAACAGGTCACATCACTGGATCCCT TGCAGACATTCCCCAGCACCAGCCTGGAGTGTGGCAGCCCCACTGGGTGGCTAGACTCAG AGGAGCAACAGCATTCACAGTAGTCTGGCT-------CTCAGGGACTCCTACTCCTAGGG GAAGGGGGAGTGCACCACATCAAGGGAACACCCCATGGGACAAAAGGAATCTGGATGGCA GGCCTTGAGTCCCAGATCTTTCTACTGGTGGGAAG----------------------TTT CTTTCAGCAGAGGCACAGTTGCAGTGCTGGGCTCAGTGGGGAAAGTCTGAAGCTCTACCC CAACA-GTCAGGCATCCCTGGTGCTCATGAAGGGTCTTTTGGAGAAGGGGACGTCTTTTC CCCCTTGTCCACCACTGCAGACAC------------------------------------ --------------------------------------------AGCTGGGGCTTTTCCC ATGGGAGCTCAGCATGGGTACACCTATAGACAGCCTTTCTGGAACACTTCAGGG------ ------------------------------------------------------------ -----------TGACTGCATCCCCACAGGAGGAGTACACTCCAGGTTCGGGCTTGCATGA GAGGC-----------------AGAGTCACAATTCCTCTCTACTTGGAACATCAACATTC CTACAGATGAAAAGAGGTGCTGGTCTGA------------------TCTGAATAGCCAGA AT------------ACTGGGTCAGGAGTGTGACTGGGAGGTGGATTGCTTTCCTGCTGGC CTGGCAGGGGAGCTGAGGTGGCTCCAACCCTTCCCCCTGATAAGACCTCAGTGTGTTTCA CTGAGAGTTTCTCCACCTACCTCTGTCAAGGCTGGGACCTCTGCCCACTATTGGGTATTG CATTTATCCACCTGCTTTAGCCACAACCAGTTTCT----ACCCAGGGACACCTCCCCTAC TGGCCTGAAGCCTGAACTATTCAACCCATTAAAAAAATTACTGGGGAAAAAATAAA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------TATAAAAAAATATCCCCCAGGGAAGGAATGAGATAAG CTTCAAGAGACCTCTGCCATTCCAACCCCATAGGAGATAGTGAACTTGCTCACACACCAA GCACATTGCTACTACAACCAGCATCTGAGAAAGCCATCATACAAAGA------------- --C-----------TCTCTATTACCAAGAAACTAGGAACTTATACAGAGAGTCTTCACCC C-------TGAAAGCACCAAGAGCCGAATTAGG-------------CTATAATAAACTAT AAACATTAAAGTCACATCCTTAAGGGGAACAATAAATTTAAAAACAAACAG--------- ---------AAAAAAAAATTTTTAAAAAAAGTCAAATC---------------------- -AAAAATAAATTCAAGAATAATTAGAAGAAATAGTCTACCCAAAAGAGAAGAAAAAAGAA AAATAAT----------------------------------------------------- -------------------------------TGAGAAGGAA-----CCAGAAAAATAATT CTG-------------------------------------GCAATATGA--------CAA AACA----GGGTTCTA-------------TAAC--ACCC--CCAA---A-AG-------- -------ATC----ACACTAACTC-------------------TC-CAG---CAATGGAT CCAAACC----------------AAG---ATGAAATCTTTGAAATACCAGATAA------ ------AGAA------------TTCAAAAGGTTGAT-TATTAAGTTACTCAAGGAGAT-- --ACAAGAGAAAGGT--------------------------GAAAACCAACAT-----AA AGAAATT----------------------------------------------------- --ACAAAAA--------------------------------------------------- -AAATTCA----------GGATATGAATAAAAAATTTTCTAAAGAG-------------- -------------------------------------------ATAGATATTTTAAAGAA ----------AAAT---------------CAATCAG------AAC---------TTCTG- GAAA----TGAAA---------GACAC---ATTTAGGGAATTACAAAATGCAGTGGAA-- ---AGTTTTAACAATAGA----------------CTAG--------------------AC C--AAGT------------------AGAAGAAAG-AAT-TTCAG--AGCTTGAAGAC--- -AAGGCTTTTGAAT-T-----AACCCAATCAG---------ACAAAAATAAA---GAAAA AAGA---ATAAAAAGA-AA---------TGA---ACAAAGTCTCC--AAGAAATATGGG- ATTAT--------G---TAAAATG--GCCAAACCTAAGA--A-TCATTGG--TGTT---- ----------CCTGAGG---GAGAAGAGAAAGCA---AAAAGTTTGG---------AAAA CTTATTT---GA-----GGGAATAATTGAG--GAAAACTTCCCTGGCCT----------- ---------TGCTAGAGATTT--AGAC--ATCCAAATAC-----AAGAAGCTCAAAGA-A CTCCTGGGA------------GATTCAT-TGC--------------AAAAAGAACATCAC C-------A---------------------AGGCATATAGTCATCAGGCT------ATC- TAAAGTCAATA---TGAAGG--AAAGAATTC----------------------------- -------------TAAGAGC--AGTGAGACA---AAAGCATCAGGT-------------- -----------AAC---CTATAAAGG-AAAACCTA--------------TCAGACT--AA CAGCAGACTTC-----TCAGCAGAA--ACCTTA-CAAGC------CAG-AAGGGATTG-- -----------GGG-TCCTATC-T-------TTAGCC--TCCT-------------TAAA CAGAA---------------TAACTG--TCA--GCCAAGAA--------TTT---TGTAT CCA-----------GCAAAACTAAGT-----TTCAT-AAATGA-------AG-------- ------------------------G-AGAAATAAAGTCTTTTTCAGACAAGC-AAATGCT GAGGGA-ATTTGTCACTACCAGAC---CAGCCCTAC-AAGAA------------------ --------------------ATGCTAAAAGG----------------------------- -----------------------------------AGTTC--------------TAAATC TTG----------------------------------------------------AAACA AAAGGTCATTTTGAACAAGAATAGAACCTCTTG--------------------------- ------------------------------------------------------------ ------------------------------------AAAGCAT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------AAAA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CTCACAGGGCC-------------------------TATAA A-------------------------------------------------ACAATAACAC AATGAAAAAA-CACAA-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TAAAGAAAACAAA-------------------GTATCTA GGTAA------------------------------------------------------- ------------------------------------------------------------ -------------CAACTAACATG------------------------------------ ------------------TGACT-------GGAACAGTA--------------------- ------------------------------------------------------------ --------------------CCTCACATC--TCAATATTAAC-ATTGAAT-------G-T AAAT--GGCCT--AAATGC---TCCACTT----------------AAAAGAT------AC AGAT--TGGCAG----AATG---------GAT-------AAAA---AATCACAAACCAA- ---ATA-------TCT-GCTGTCTT-CAAGAGACTCACCT-AACAT--ATAAGGATTCAT A-TAAACTCAAGGTAAAGGGG---T------------GGAAA----A-AGATATTCCATG C--------------AAATGG------AAACC---------------------AAAAG-C AAGCAG--GAGT----AGCTATTCTTATATC-AGATAAAACAGACTTTAAA-GC------ ----AACAACAG---TAAAAAAAGAC-AAAG-AAGGTCAT------TATAT------AAT GATAAA---AGGATCAATC------CAACAA---GAAG--------AT-ATTACAA-TCC TAA-----------------A----TTTATATG---------CACCTAACACTGGAGCTC CCAG--ATT-CATAAAACAATTACTACTAGACCT--AA----GAAATGA---------GA TAGACAGCAAC------ACAATAATAGTGGGGGACTTCAACA----------------CT CCACT------GACAGC-ACTAGACAGATCAT---------------------CAAGAC- -----AGAA-------------AGTCAACAAAGAAACAATGGACTTAAAC-TACACTCTA GA------ACAAATGG---ACCTAACAGATATTTACA--GA----ACATTCTACCCAAGA AC---TGCAGAATATACAT------TCTTCTCATCAG-----CA--CAT-GGAACATTCT --C----CAAGATAGACCATATGATAGGCCACAAAACAAG-------------------- -TCTCAATAAATTTTAAAAAA--TCAAAAT----------------CATATCAA------ -GTATCTTCTCA---GACCACAGTGGAA-TAAAACTAGAAATCAAC-------------- ----------------------------------------------TCCA--------AA --------------AGG-AACCCTCA---AAACTATACAA----ATACATGGAAA--T-T AAACAATCTG-CTCCTGAA---TG-ATTTTTG--GGTTAACAATGA--AAT--C-AAGAT GGAAATT---------------AAAAAATTCTTT---GAAAT------------------ ------GAATGATAATAG-TGA------------CACAAG--TTATCAAAACCTC-TGG- GA-----TACAGCAAAAGCAGTG-----------------------------CTAAGAGG AAAG--TTTATAGCACTA----AATGC----CTACATCAAAAAGT---CTGAAAGATCA- --CAAATTGAC-AACCTAA-TGTCACACCTC---AAGGAAC--TAGAGAAAC------AA GA-----ACAAACTAAAC-------------CCAAAGC--TAGCAGAA-GAAAAGAAATA ACA---AAGATCAGA-------------------GCAGAACTA---AA-T-GAAATTGAA ACAAA------AA------------------------------------AAA-------T ACAAAAGATC-A---------ATG----AAACAA-AAAGTTG------GTTCTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATTGATAGACCA---TTAG CTA------GATTAA--CCA------------AGAAA------------------AGAAG A---GAGA-AGATTC-----------------AAATAAG--------CTCAA-----TT- ---------AGA-AATGAAA--CT----------GGAGA---CATTACAACCAACACC-A CA-GAAATA--CAAAAGAT-CATTTA---------AGACTACT--ATGAA---------- -----------CAC---CTCTATGCACACAA---ACTAGAAAATCTAG---AGGAAAT-- GGATAAATTCCT----------GGAAACA---------TAC-----AACCCTCCT----- -AGATTAAATCA---GGAAGAAATAGAAACCCTGAAC----------------------- AGACC------------AA-TAACAAGCAGTGAGATTGAAT-C---------AGTAATT- -TAAAAAATTTCC----AAAAAAAAAAAAAG---CCCAGGGCC--AGATGG--------- ------------ATTCACA-GCTG--AA-------------------TTCTA-------- ----CCAGACATTC---AAAGAA-GAATTGG--TA-CCAATC----------CTACTGAA ACTATT----CC---AAAAGATTGAG------AAAGAG-GG-----------AATCCTCC CTAACTCATTCT-----ATGAAGCC-----AGTAT---CACCCTG-ATAC---------- ----------------------------------------C--AAAAC-------CAGGA AAG---------------------GAC---ATAACAAAAAA---AGAAAACTAC------ -------------A-GACCAATAT---CCC----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-TAACCA------------------AA--TC--------------CA--ACA----- --------GCACATC---------AAAAAGATAATACA--CCATGAT------------C AAG---TGGGT-TT----------CATCCCA------------GG--GATGCAGGGATGG -T----------------------TT-AAC-----ATATGC--AAGTCAATAAA--TGTG ---ATACATCACAT------AAACAG----AATTAAAAACAAAAAC---CATATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTCAATAA---AATCCAGCATCCCTT- ---------------TATGA---------T---A--AA-----AACCCTCAAC---AAAC TAGGCATAGAAGGGACAT-----ACCTCAAAATAATAAA--------------------- ------AGCCATATAT-GACAAA--------CCCACAGC-----------CAACAT--CA TACTGAATGGGGA-----AAA-GTTGAAAGC----ATTC---CCC----CT--GAGAACT GGAACA----AGACAAGG-ATGC--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAGGGCATCCAAATTGGA---AAAGAG------GAAGTCAAA--C--------- ------TATCACTG-TT--T---ACCGA------TGATAT------GATTGTATACCTA- -GAAAACC--CTAAAGA---CTCCTCCA---------A---------------AA--GAC TCCTAGATTT---------GA--TAAATGAATTCAGTAAAG--TCT-----CAGGTTAC- --AA-------------------------------AATCAA-------------TGT--- ACACAAAT----CAGT-------------------------------------------- -----AGCACTGC--TA-TACACCAAC---------------AATGACCAAG-----CTG A------------------GAATCAAATC-AAG----AACTCAATCCCTTTTACAATAGC TGCA------------------AAAAAAATA---------AAA------TACCTAGGAAT ATACTT--------AA--C-CAAGGAGGTG---A---AAGATCTCT---ACAA-GGAGAA CTACAAAACAC------TGCTG-AAAGAAATCA-TA------------GATG-------- ------------ACAC--AAAC--AAA---TGGA---AA--CACAT---------CCCA- --TGCTC------ATG-GATTGGAAGAATC-A---A---TATT--------------G-- TGAAAATG-----------------------------------------ACCAT--ACTG CCC-AA--AGCAATCTACA-------------------GA---TTCAATGCA---ATT-- ------C-CTATCAAAAT--A---------------------CCAACA-TC---ATTTTT ------------------------------------------CACAGAATTAG------- ----------------------AAAAAACAAT------CCTAAAA---TTCATATGGAAC C-------AAAAAAGAGCCC---AA--ATAGCCAAAGCAATCCTAAGCA---AAAA--GA ACA---AATC--T-------GGA--GGCATCACA---TTACCAGACTTCAAATT-----A TACTAC-------------------------AA---GGCTATAGT-TACCAA---AAC-A GCA--------------TGGTACTGG--TA------------T---AAAAGTAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAG-- -CCAA----------------ATA-------CTTACAA----CCAACT--GATCTTT--- GACAAA--GCATACAAAAACATAA--A-------------------TTGGG--GA---AA GG------------ACACCCTATT--TAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-CTAGCCA---------------CATGT-AGAAGA---ATG ---------AAACTGGATCCC---TATCT-----------CTCACC--TTA--T---ACA AAAA-TCAACT-CAAGATGG---AT---CAAAGAC---TTAAATCTA--AGACCTGAAAC CAT------------------------AAAAATTCTAGAA---------------GATAA ---CCTA------G------------------G-AAAAACTCTTCTGGACATTG--GCC- -----TAGGCAAAGAAT-----TTATGACTAA-GACCCCA---AAAGCAAATGCAAC--- --AAAAACA---AA----AAT---AAATAAA-TGGGAC----------CTAATT-AA--- ACTAAAAA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAATAAT-------------CATCAGAGTAAACAG------------------- ------A-------------CAACCC------ACAGAA--T-GGGAG---AAAATATTT- --GCAAACTATGCAT--------CT-------GACAAAGGAC--------TA--ATATC- ---CAGAATCTACAAG-GA--ACTCAA---ACA------AA--TCAGC------------ --------------------AAGAAAAAA---AAT--AATCCCA-TCAA---AAAGTGGG C--AAA---------TGA--CATGA---AT---AGACATTT------------------- -----CTCAAAAGAA--------GATATAC---AA-ATGGCCAAC--AAACATATGAAAA AAT----------GCTCAACATCACTA-ATCATCA------------------------- -----GGGA-AATGCAAA-----------------TT-AAAACCACA-------AT---- ----GA---GATACCA---------CCTT----ACTCCTGCAAGAATGGCCATTAT---T A--AAAAG-------TCAAAAA-----ACAATA-GATG--T------------------- ------TGGC-ATGGATGTG----------GTGAA------------------------- ------------AAGGGAATACTTAT-ACACTGCTGG--TGGG----------------- ----------AATGT--A-------------AATT---AGTAC----AACCTCTATGG-- ------AAAACAGTA--TGGAG--A-TTTCTT--AAAGAACTAAAA--GTAGATCTACC- -ATTC---GA--TCCAGCAATCCCA---------------------CTACTGGG-TATC- --------------TA-CCCAAAGGAA------------AAGAAGTCA----T------- --------------TATATCAA--AAAGACACCTGC---------ACACA----TATGTT TATT--GCAGCACAATTCACAA-TTGCAAAGATAT--G--GA--ACCA--ACCTAA---G TGCCCATCA---ACCAATG-----AGTGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAT----ACACCATGGAATAC-----T--ACTCA GCCATAA----AA----------------------AAGAATGAAATAATGTCTTTT---- ------------------------------------------------------------ --------GCAGCAACTTGGATGGAG-C---TGGAGGCCATTATTCTAAGTGA------- ------------------------------------------------AGTAACTCAGGA ATGG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAATAC-CA-------- ---TAT---GTTCTCACTTAT----------AAGTGGGAGCGAGCT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AAGCTATGGGTATGCAAA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------GGCATAC----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GTGGTAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----AATGGAC-----------------------------------------------A TTG-------GAGACCAGAA------------------GGGGGGAGGGTGGGAGGGGG-- -------------------------------------------------GT--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GAGGGATAAAAAACT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ACATATTGGGTA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----CAATGTACACTACTCGGGTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ACGGGTGCACTAAAATCTCAGACTTCACCACT------------- ------------------------------------------------------------ ------------------------------------------------------------ -ATACAAT-TCATCCAT------------------------------------------- -------------------------GT-----------------AACCAA---------- -------------AAACCACTTGTACCCCAAAAGCTATT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAAATAAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >L1ME3C ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------ATCATGGAGGATAAGAGACAGG ACTAGCTTG---------------------------CAGCTCCGACTCGGAC-------- ---------------------------------------AGAGCAGCATGCGAAGGTTTG CATCGTGAATTTTAGCTCCAGAATAACTGCAAGAACAAACCAT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------GAACCCCCAGAG------GACCCACAGACCCTCTTAAGGAAG TAGAGTGCTCCTGC-------------------------------AGGAACTGGGAGATA CCCCAAATACTATG---------------------------------------------- ------------------------------------------------------------ ---------AGTGCCCCACCTGTGGAAGTAGAAA-----AG---GAAGATCCTCTGCTCC TGAACACACACCCTTA------------------------------------CTGGGGAA ACGGAAAATTTGTTTGCAGGACAAGTTTCTGACCTTACCTGGAGCTGAGTCAAT------ ---------------------------------------------TTAGAGAGCTGAGTA AAATACAGGGGTAGAGGAAGCAGCAGGAAGGGTCCTGGGA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GCTCACTGGGTCCCCAAGCTGGCCATTCA TGCCTGGCACCACAGGGA-------TCCATCGGGAGGGTGTTCAGAGGTACTGGGGAAAA TGCCACAGGGAGAAGG-------------------------------------------- -------------------AAGTCTCCAGCTGAACTTTGTAACAATTTGAACCAGGTGAG AAGCCTCCTGGCCAGAACTCAGGGGAGAGCAT-------------GAATCCAGTCAGCAG ATTC-------------------------------------------------------- ---------------------------------------CACAGGTGGGGGAAGAACTCA AG--------TCCTTTTCTTTCACAGCTGGGAGGCGGGTAG------------------- ------------------------------------------------------------ ----CCTGGGGCAAGTTCTCAAGCCCTGCTTG---------------------------- ------------------------------------------------------------ -------------------------------------------------CCTGCTGCCTG GAAACAAACTCTGTGCTGTTGGAGGGGGCATAGTGGGAGTGAGACCAGCTCTTCAGTTCG TGTGGGAGCTGGGTGAGGCCTGTGACTGTCAGCTTTC----------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------CCCCACTCCC-------CTGACAACCTGCATGACTCAGCA GAGGCAGCAATAATCCTCCTAGGTACAC-------------------------------- ------------------------------------------------------------ -------------------------------------------------AACTCCGTTGA CCTGG-GAACCTCACCTCCAACTCTCACAGCAGCTGC----------------------- ------------------------------------------------------------ --------------------------------------------AGCAAGACCTACCAAA GCAG------AGCCTGAGCTCAGACACGCCTAGCCCTACCCCCACCTGATGGCC------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CTTTCCTACCCACCCTGGAAG CTGAAGACAAAGGG---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CATATAATCTTGGGAGTTCTATGGCCCTGCCCA CCACTGGTTCCTCTCCATACTACCACAGCTGATGC----TCTCTGGTAAGCGTTACCTCC T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AGCAGGAGG-----------CCAACCAGCACAAAAAT AG---------------------------------------------------------- ------------------------------------------------------------ --A-----------GCATTAAACGACCAAAGCTAAGAACCCTCACAGAGT---------- ----------------------------------------------CTCCATTTCACCCC ACTGCC---------------------------------ACCTTCACTGGA--------- ---------ACAGGTGCTGGTATCCATGGCTA---------------------------- -AGAGACCAATAGACAGTTCACATCACAGGACTC-------------------------- ------------------------------------------------------------ -------------------------------TGTGCAGACA-ACTCCCAGTACCAGCA-- ----------------------------------------TAGAGCCTG--------GCA GACTTGCTGGCTGGCC-------------AAAC--------CCAGAAGAGAGATAACA-- -------ATC----ACTGCAGCTCGGCTCCCAGGAAGCTACATCCATAGGACAAGGGGGA GAGCACT----------------ACATCAAGGGAACACCCCATGAAACAAAAGA------ ----------------------ATCTGAACAACAGCCTTCAG------CCCTAGACCTTC CCTCTGACAGAGGCT----------------------------ACCCAAATGA-----GA AGAAACT----------------------------------------------------- --AAAAAAA--------------------------------------------------- ------------------CACACACACACACACAG------------------------- -------------------------------------------AAAGCCAACTCTGGTAA ----------------------------TATGACAA------AAC--------------- AAGGCTCTTTAAC---------ACCAC--------------------------------- ---AGTCTCAGTAATAGA----------------ATTG--------------------AA C--AAGT------------------AGAAGAAAG-AAA-TTCAG--AGCTCAAAGAC--- -AAGGTCTTCGAAG-T-----AGCCCAAACCA---------ACAAAGACAAA---GAAAA AAGA---ATAAGAAAA-TA---------TGA---ACGAAGCCTCC--AAGAAGTCTGGG- ATTAT--------G---TTAAATG--ACCAAACCTTAGA--A-TAACCAG--TGTT---- ----------CCTGAGG---AAGAAGAGAAATCT---AAAAGTTTGG---------AGAA CATATTT---GG-----GGGAATAATCAAA--GAAAACTTCCCTGGCCT----------- ---------TGCTAGTCACCTAAAGAC--ATCCAAATAC-----AAGAAGCACAAAGA-A CACCTGGGA------------AATGCAT-CAC---------------AAAAAGGTTGCAA T-----------------------------AGGCACATTGTCATCAGGTT------ATC- TAAAGTTAAGA---TGAAGG--AAAGAATCT----------------------------- -------------TAAGAGC--TGTGAGACA---AAAGCACCAGGT-------------- -----------AAC---CTACAAAGG-AAAACC----------------TCAGGTT--AA TGGCAGATTTC-----TCAGCAGAA--GCCATG-TAAGA------TAG-AAGGGATTG-- -----------GG--CCCTATC-T-------TGAGCC--TCCT-------------GAAA CAAAA---------------TAATTA--TCA--GCTGAGAA--------TTT---TGTAT CCA-----------GCAAAATTGAGC-----ATCAT-ATATGA-------AG-------- ------------------------G-AAAGATACAGTCATTTTCAGACAAAC-AAATGCT GAGAGA-ATTCACCACCACAAAGC---CACCACTAC-AAGAG------------------ --------------------CTCCTAAAAGA----------------------------- -----------------------------------AGCAC--------------TAAACA TGG----------------------------------------------------AAAGA AACA---------------ACCAGTA---------------------------------- -------------------------------CCAGCCACTGCA----------------- ------------------------------------AAAACAT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GC-------- ------------------------------------------------------------ --------------------------------------------------AAAATTGTCC TGGGAACACA-TCAAAAC------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AGAACGTCTT TAAAGCATAAATCACACATGACCTATAAAACAAAAATACAAGTTAATTAGCAAAAGCAAC AACAAAAAT--------------------------------------------------- ---------------------AAAAAAACGAGGT--------------AC---ACAGGCA ACAAA------------------------------------------------------- ------------------------------------------------------------ -------------TAACATGA--------------------------------------- ------------------TGACA-------GGATCAAAT--------------------- ------------------------------------------------------------ --------------------TCACACATC--TCAATACTAAC-ATTGAAT-------G-T AAAT--GGCCT--AAATGC---TCCACTT----------------AAAAGAT------AC AGAA--CTGCAG----AATG---------GAT-------AAGA---ACTCCAGATCCAA- ---CTA-------TCT-GCTGCCTT-CAGGAGACCCACCT-AATGT--ATAAGGACTCAC A-TAAACTTAAAGTAGAAAGG---T------------GGAAA----A-AGGCATTTCATG C--------------AAATGG------ACACC---------------------AAAAG-C GAGCAG--GGTT----AGCTATTCTTACATC-AGACAAAACAAACTCTAAA-GC------ ----AACAGTGG---TTAAAAGAGAC-AAAG-AAGGACAT------TATAT------AAT GGTAAA---AGGCCTTGTC------CAACAG---GAAA--------AT-ATCACAA-TCC TAA-----------------A----CATGTATG---------TACCTAACACTGGAGCTC CCAA--ATT-TATAAAACAATTACTAATAGATCT--AA----GAAATGA---------GG TAGACAACAAC------ACGATAATAGTGGGGGACTTCAATA----------------CT CCACT------GACAAC-AATAGACAGTTCAC---------------------CAAGAC- -----ACAA-------------AGGAAACAAAGAAACAATGGATTTTAAC-TTATCTCTG GA------ACAAATGG---ACTTAACAGATATTTACA--GA----ACATTCTACCCAACA AC---TGAAGAATATACAT------TCTATTCATCAC-----CA--CAT-GGAACATTCT --C----CAAGATAGACCACATGATAGGGCACAAAACAAA-------------------- -TCTCAGCAAATTTAAGAAAA--CCGAAAT----------------TATATCAA------ -GTATTCTCTCA---GACCACAGTGGAA-TAAAACTGGAAATCAAC-------------- ----------------------------------------------TCTA--------AA --------------AGG-AGCCCTCA---AAACCATGCAA----ATACATGGAAA--C-T AAATAACCTG-CTCCTGAA---TG-ATTATTG--GGTGAACAATGA--AAT--CAAAGGT GAAAATTTA-------------AAAATATTCTTT---GAACT------------------ ------GAATGATAATAG-CGA------------CACAAC--CTACCAAAACCTC-TGG- GA-----TACAGCAAAAGCGGTG-----------------------------CTAAGAGG AAAG--TTCATAGCATTA----AATGC----CTACATCAAAAAGT---CTGAAAGAGCA- --CAAATAGAC-AATCTAA-GGTCACACCTC---AAAGAAC--TAGAGAAAC------AA GA-----ACAAACCCAAC-------------CCAAACC--CAGAAGAAGGAAAATAAATA AAC---AAGATCAGA-------------------GCAGAATTA---AAGT-GAAACTGAA ACAAAAAATACAAAAGATAATTGAAACAAAAAATACAAAAGATAAATTGAAACAAAAATT ACAAAAGATA-A---------ATG----AAACAA-AGAGCTG------GTTCTTTGAAAG GATAAA------------------------------------------------------ --------------------------------TAA-----AATTGATAGACCA---TTAG CGA------GATTAA--CCA------------AGAAAATAAAGACAATTTTCGAGAAAAG AAGAGAGA-AGATTC-----------------AAATAAG--------CTCAA-----TT- ---------AGA-AATGAAA--TG----------GGAGA---TATTACTACTGATACC-A CA-GAAATA--CAAAAGAT-TATTCA---------AGGCTACT--ATGAA---------- -----------CAC---CTTTACACACATAA---ACTAGAAAACCTAG---AGGAGAT-- GGATAAATTCCT----------GGAAATA---------TAC-----AACCCTCCT----- -AGATTAAACCA---GGAAGAAGTAGAAACTCTGAAC----------------------- AGACCAAT---------AA-TAACAAGCAATGAGATTGAAA-T---------GGTAATTA ATAAAAATTTCCC------AACCAAAAAGAG---TCCAGGACC--AGACGA--------- ------------ATTCACA-GCTG--AA-------------------TTCTA-------- ----TCAGACATTC---AAAGAA-GAATTGG--TA-CCAATC----------CTATTGAC ACTATT----CC---AAGGAATAGAA------AAAGAG-GG-----------AATCCTCC CTAAATCATTCT-----ATGAAGCC-----AGCAT---CACCCTA-ATAC---------- ----------------------------------------C--AAAAC-------CAGGG AGA---------------------GAC---ATAATCAAAAA---AGAAAACTAC------ -------------A-GACCAATAT---CCT----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-TAACCA------------------AA--TC--------------CA--ACA----- --------GCACATCTTT------AAAAAGGTAGTCCA--CCATGAT------------C AAG---TGGGC-TT----------CATCCCA------------GG--GATGCAGGGCTGG -T----------------------TT-AAC-----ATATGC--AAGTCAATAAA--TGTG ---ATACACCACAT------AAACAG----AATTAAAAACAAAAAA---CACATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTTGACAA---AATACAACATCCCTT- ---------------TATGA---------T---T--AA-----AACTCTCAAC---AAAA TCGGCATAGAAGAGACAT-----ACCTCAATGTAATAAA--------------------- ------AGCAATCTAT-GACAAA--------CCCACAGC-----------CAACAT--TA TACTGAATGGGGA-----AAA-GTTGAAAGC----ATTC---CCC----CT--GAGAACT GGCATA----AGACAAGG-ATGC--CCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTTCTATTC---AACATAGT ACC---GGAAGTTCTAGCCAGAGCAAT--------GAG-GC------AGAAG---AAAAA --AATAAAGGGCATCCAAATTGGT---AAAGAG------GAAGTCAAA--C--------- ------TGTCGTTG-TT--T---ACTGA------TGATAT------GATTGTATACCTA- -GAAAACC--CTAAAGA---CTCATCCA---------A---------------AA--AGC TCCTAGAACT---------GG--TAAATGAATTCAGCAAAG--TTT-----CAGGATAC- --AA-------------------------------AATTAA-------------TGT--- ACACAAAT----CAGT-------------------------------------------- -----AGCCTTGC--TA-TACACCAAC---------------AGCAACCAAG-----CTG A------------------GAATCAAATC-AAG----AACTCAATCCCTTTTACAATAGC TGCA---------------------AAAATA---------AAAATTAAATACTTAGGAAT ATACCT--------AA--C-CAAGGAGGTG---A---AAGACCTCT---ACAA-GGAAAA CTATAAAACAC------TGCTG-AAAGAAATCA-TA------------GATG-------- ------------ACAC--AAAC--AAA---TGGA---AA--CACAT---------CCCA- --TGCTC------ATG-GATGGGTAGAATC-A---A---TATT--------------G-- TGAAAATG-----------------------------------------ACCAT--ACTG CCA-AA--AGCAATCTACA-------------------AA---TTCAATGCA---ATC-- ------C-CTATCAAAAT--A---------------------CCACCA-AC---ATTCTT ------------------------------------------CACAGAATTAG------- ----------------------AAAAAACAAC------TCTAAAA---TTCATATGGAAC C-------AAAAAAGAGCCC---AC--ATAGCCAAAGCAAGACTAAGCA---AAAA--GA ACA---AATC--T-------GGA--GGCATCACA---TTACCCGACTTCAAACT-----A TACTAT-------------------------AA---GGCCATAGT-CACCAA---AAC-A GCA--------------TGGTACTGG--TA------------TAAAAAAAATAGGCA--- ---TATAGAC--CA---ATGG-AACAGAATAGAGAACAC------AG---AAATAAAC-- -CCAA----------------ATAAATTTGCAATGCAA----CCAACC--GATCTTC--- AACAAA--GCAAACAAAAACAGAA--A-------------------GTGGGGAGA---AA GG------------ACACCCCATT--CAACAAATGG---------------TGCTG---- ------G-GATAAT--TGG-CTTGCCA---------------CATGT-AGAAGA---ATG ---------AAACTGGATTCT---CATCT-----------CTCACC--TTA--T---ACA AAAA-TCAATT-CAAGATGG---AT---CAAAGAC---TTAAATCTA--AGACCTAAAAC CAT------------------------AAAAATTCTAGAA---------------GATAA ---CATT------G------------------GAAAAAAACCCTGTAGACATTG--GCTT A----TAGGCAAGGACT-----TCATGACCAA-GAACCCA---AAAGCAAATGCAAC--- --AAAAACA---AA----GAT---AAACAGA-TGGGAC----------TTAATT-AA--- ACTAAAGA-----A------------CTT-CTGCA-------CA--------------GC -AAAAGAAACAAT-------------CAGCAGAGTAAACAG------------------- ------A-------------CAACCC------ACAGAC--T-GGGAGAAAAAAATCTTC- --GCAATCTATACAT--------CT-------GACAAAGGAC--------TAATATATC- ---CAGAATCTACAAT-GA--ACTCAA---ACA------AA--TCAGT------------ ---AAG------AA------AAACAAACA---AAC--AATCCCA-TCAA---AAAGTGGG CTATAA---------GGA--CATGA---AT---AGACAATT------------------- -----CTCAAAAGAA--------GATATAC---AA-ATGGCCAAC--AAACATATGAAAA AATCGTCATCATCACTCAACATCATGA-ATGACCA------------------------- -----GGGA-AACGCAAA-----------------TC-AAAACCACA-------AT---- ----GT---AATACCAGTTAGAAAGCCTT----ACCTCTGCAAGAATGGCCATAAT---- ACAAAAAA-------TCAAAAA-----ACAGTA-GATG--T------------------- ------TGGC-ATAGATGCA----------GCTAT------------------------- ------------CAGGGAACACTTTT-ACACTGCTGA--TGGG----------------- ----------AATGTAAA----------CCTAAGT----GTAC----AGCCATTGTGG-- ------AAAACAGTG--TGGAG--A-TTCCTC--AAAGAACTAAAA--GTAGAACTACC- -ATTT---GA--TCCAGCAATCCCA---------------------CTACTGGG-TATC- --------------TA-CCCAGAGGAA------------AAGAAGTCA----TTGTACAA TAAATATATGAAAATATATGAA--AAATATACTTTC---------ATACA----TATGTG TATA--GCAGCACAATTTGCAA-TTGCAAAAACAT--G--GA--ACCA--ACCCAA---A TGCCCATCA---ATCAACG-----AGTGGATAAAG--AAAA----TG------------- -----TGGCA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ATGCA GCCATACTGCTGC----------------------TGAAAGATCATTAGG---------- ------------------------------------------------------------ --------GAAAAAACAAAAATCAAG-A---TGGAATAAAAAATTCT------------- ------------------------------------------------TCGAACTGAATG ACAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----TAAT---------------------------------------------------- ---------GATGCAATCTAT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CAAAACCTCTGG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------GATACAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------CAAAGGT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GGTGCTAAGA------------------------GGAAAGCTCATAGC-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -CCTAAGT-ACCTAAGT------------------------------------------- --------------------------------------------ACCTAA---------- -------------------ACTGACCTTCTAAGGTCACATCTCAA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAAACTAGA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GAAACAAGAAC------------------------------------------ ------ >L1ME3G ------------------------------------------------------------ ------------------------------------------------------------ -----------------AAATAAG-----------------ACCTCGGGAAAGAATCAGC AGTA-----------------------------------TCACCAGTCTATG-------- ----------------------------------CATATTGCAGGGCCGACAGACT---- -TCACATAG--------ATA---ACCCCGCCAAAATATAGAAG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------AACAGTG----ATTACTCCTTACA------AAGAGCCAAAA-------TTAACA AAGA-----------------CTGATTCTATTCC---------T-CAGACTGGAACAACT ATTCGTATCAATTA----------GAAAGTA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------AAATACCT ATTACAACCAACAGGGCAAAATATTGCTGTGAGATAAACA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------AAAAAGAGGAT TTCTCACAAAAACGGGGATATATAAAAAGACT-------------ACATCTAAATAATGA GATA-------------------------------------------------------- --------------G------------TGTTTCAAA---TTAAAATTAAGGCCAACTTCT GA-------------------CAAGACTGACACAAACACAA------------------- ------------------------------------------------------------ ----GACAACAAAA---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------ATCTGATAGAAACACA GAAA------TGTTCAGTACCAATCTTTTAAA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------TTTTATAAAATATGGCACTCTCTTTACAATCAGCTAAT ATGCATAGAGTGAA--------------------------------ATAAAA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AAAACAAAAGAGTATAAAGAAATAAGGCAACAAACAA AATCAACCCCAAAAAAGAACAGTATTAGAAGTT--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------TTAACAATG-----------GTAATTAAAATAATTGA AAACTTGACTAGATAGGTAAAAAAATCTGCATGATCTCAAAGACCTAGAGACTGTCATAT GAGACTATTTCTCATTTTTTATTAAGAAAATAAAATGAAAATTCTTG------------- --A-----------GATGAAAAATACAGTATCTAAGATGAAAAATACATT---------- --------GGATAGGCTCAATGGCAAATTAGAGACAGCAGGAGAAAAAATTAGTGAACTT GAAGACATGTCTATAGAAA--------------------ATTTTCAAAAAG--------- ---------TAAAA---------------------------------------------- -CGAAAGAA-------------------AAAATAATT----------------------- ------------------------------------------------------------ -------------------------------TATAAAATGT-----TCAGAGCATCA--- ----------------------------------------GAGACCTAT--------GGG ACAACATCAAGTATTA-------------TAAA--CTGTGTGTAATCCAACA-------- -------ATC----ACACTAGCTC-------------------AC-CAG---CAATGGAT CCAAACC----------------AAG---AAGAAATCCCTGATTTACCTGAAAA------ ------AGAA------------TTCAGGAGGTTAGT-TATTAAGCTAATCAGGGAGGC-- --ACCAGAGAAAGGC--------------------------GAAGCCCAATGC-----AA GGAAATC----------------------------------------------------- --CAAAAAA--------------------------------------------------- -TAATACA----------AAAAGTGAAGGGAGAAATATTC-------------------- -------------------------------------AAGGAAATAGATAGCATAAATAA ----------AAAA---------------AAATCAA------AAC---------TTCAG- GAAA----CATTG---------GACAC---ACTTATAGAAATGCAAAATGCTCTGGAA-- ---AGTCTCAGCAATAGA----------------ATTG--------------------AA C--AAGT------------------AGAAGAAAG-AAA-TTCAG--AGCTCAAAGAC--- -AAGGTCTTTAAAT-T-----AACCCAATCCA---------ACAAAGACAAA---GAAAA AAGA---ATAAGAAAA-TA---------TGA---ACAAAGCCTCC--AAGAAGTCTGGG- ATTAT--------G---TTAAACA--ACCAAACCTAAGA--A-TAATCGG--TGTT---- ----------CCTGAGG---AAGAAGAGAAATCT---AAAAGTTTGG---------AAAA CATATTT---GG-----GGGAATAATCAAG--GAAAACTTCCCCAGCCT----------- ---------TGCTAGAGACCT--AGAC--ATCCAAATAC-----AAGAAGCACAAAGA-A CACCTGGAA------------AATTCAT-TGC--------------AAAAAGATCATCAC C-------T---------------------AGGCACATTGTCATCAGGTT------ATC- TAAAGTTAAGA---CGAAGG--AGAGAATCT----------------------------- -------------TAAGAGC--TGTGAGACA---AAAGCACCAGGT-------------- -----------AAC---CTATAAAGG-AAAACCTA--------------TCAGATT--AA CAGCAGATTTC-----TCAGCAGAA--ACCCTA-CAAGC------TAG-AAGGGATTG-- -----------GGG-CCCTATC-T-------TCAGCC--TCCT-------------CAAA CAAAA-------------C-AAT-TA--TCA--GCCAAGAA--------TTT---TGTAT CCA-----------GTGAAACTAAGC-----ATCAT-ATATGA-------AG-------- ------------------------G-AAAGATACAGTCTTTTTCAGACAAAC-AAATGCT GAGAGA-ATTTGCCACTACCAAGC---CACCACTAC-AAGAA------------------ --------------------CTGCTAAAAGG----------------------------- -----------------------------------AGCTC--------------TAAATC TTG----------------------------------------------------AAACA AATAAAAAATATTAAAGGAAGGTCTTTT-------------------------------- -------------------------------AAAGCCTAAGGAAA--------------- ------------------------------------ATAATAC--CAGATGCTAATATGA ATCTATACGAAGAAATGAAGAGTATCAGAAATGGGAAT---------------------- ------------------------------------------------------------ -------------------GGGTTGGCTTATTTGTAAATATATAAATAA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GTTTTTTCATATTCTACTTTTAACCTCTTTAAAAGACATAAAATTGTT TAAATCCAAA-------------------------------------------------- -------------------TTAATAACAATGTACTGTGGTGTTTATAAAATATATAT--- --------------------AGGTAAAATGTATGACAATAAGAGCACAAAAAATTGAGAA GAGAAAAGAATTATACTATTGCAA------------------------------------ ------------------------------------------------------------ ------GATTTTTA---AACTATAGGGAAAGTGGTATAATATTACTTGAA---------- --------GGTA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GA-------- --------------------CTGTGGTAAA--------------------------CTAA AGATGTATATTGTAATTTCTAAA---------------------------GCAATAACTA AGATAATAAA-ACCAAAAGGTATA------------------------------------ ---------------------AATAATAAACA---------------------------- ------------------------------------------------------------ --------------------------------------------------AATAAAGTAA ATAAGAAGAAATTGTA-AAAAATAATTACATTAAATCAAAGAGTAGACAGAAAAATATAA AAGATGGAAAAAACAAATAA---------------------------------------- ---------------------GAAAAAGGACAAA--------------AC---AAAATTA GAATA------------------------------------------------------- ------------------------------------------------------------ -------------TA--------------------------------------------- ------------------TGAAT-------GGAATAGTA--------------------- ------------------------------------------------------------ --------------------CCTCACATC--TCAATACTAAC-ATTGAAT-------G-T AAAT--GGCCT--AAATGC---TCCACTT----------------AAAAGAT------AC AGAA--TGGCAG----AATG---------GAT-------AAGA---ATTCACCAACCAA- ---CTA-------TCT-GCTGCCTT-CAAGAGACTCACCT-AACAC--ATAAGGACTCAC A-TAAACTTAAGGTAAAGGGG---T------------GGAAA----A-AGGCATTTCATG C--------------AAATGG------ACACC---------------------AAAAG-C GAGCAG--GAGT----AGCTATTCTTATATC-AGACAAAACAAACTTTAAA-GC------ ----AACAGCAG---TTAAAAAAGAC-AAAG-AGGGACAT------TATAT------AAT GATAAA---AGGCCTTGTC------CAACAG---GAAA--------AT-ATCACAA-TCC TAA-----------------A----CATATATG---------CACCTAACACTGGAGCTC CCAA--ATT-TATAAAACAATTACTAATAGACCT--AA----GAAATGA---------GA TAGACAGCAAC------ACAATAATAGTGGGGGACTTCAATA----------------CT CCACT------GACAGC-ACTAGACAGGTCAT---------------------CAAGAC- -----AGAA-------------AGTCAACAAAGAAACAATGGATTTAAAC-TATACCCTG GA------ACAAATGG---ACTTAACAGATATATACA--GA----ACATTCCATCCAACA AC---TGCAGAATATACAT------TCTATTCAACAG-----CA--CAT-GGAACTTTCT --C----CAAGATAGACCATATGATAGGCCACAAAACAAG-------------------- -CCTCAATAAATTTAAGAAAA--TTGAAAT----------------TATATCAA------ -GCACTCTCTCA---GACCACAGTGGAA-TAAAACTGGAAATCAAC-------------- ----------------------------------------------TCCA--------AA --------------AGG-AACCTTCA---AAACCATGCAA----ATACATGGAAA--T-T AAATAACCTG-CTCCTGAA---TG-ATCATTG--GGTCAAAAATAA--AAT--C-AAGAT GGAAATT---------------AAAAAATTTTTT---GAACT------------------ ------GAACGACAATAG-TGA------------CACAAC--CTATCAAAACCTC-TGG- GA-----TACAGCAAAGGTGGTG-----------------------------CTAAGAGG AAAG--TTCATAGCCCTA----AATGC----CTACATCAAAAAGT---CTGAAAGAGCA- --CAAATAGAC-AATCTAA-GGTCACACCTC---AAGGAAC--TAGAGAAAC------AA GA-----ACAAACCAAAC-------------CCAAACC--CAGCAGAA-GAAAGGAAATA ACC---AAGATCAGA-------------------GCAGAACTA---AA-T-GAAATTGAA ACAAA------CA------------------------------------AAA-ACAAAAT ACAAAAGATA-A---------ATG----AAACAA-AAAGCTG------GTTCTTTGAAAA GATAAA------------------------------------------------------ --------------------------------TAA-----AATTGATAGACCA---TTAG CAA------GATTAA--CCA------------AGAAA------------------AGAAG A---GAGA-AAATCC-----------------AAATAAG--------CTCAA-----TA- ---------AGA-AATGAAA--CA----------GGAGA---TATTACAACTGACACC-A CA-GAAATA--CAAAAGAT-CATTCA---------AGGCTACT--ATGAA---------- -----------CAC---CTTTATGCACATAA---ACTAGAAAACCTAG---AAGAGAT-- GGATAAATTCCT----------GGAAAAA---------TAC-----AACCCTCCT----- -AGCTTAAATCA---GGAAGAAATAGATACCCTGAAC----------------------- AGACC------------AA-TAACAAGCAGCAAGATTGAAA-T---------AGTAAT-- -TAAAAAATTACC------AACAAAAAAAAG---TCCAGGACC--AGACGG--------- ------------ATTCACA-GCTG--AA-------------------TTCTA-------- ----CCAGACATTC---AAAGAA-GAATTGG--TA-CCAATC----------CTATTGAC ACTATT----CC---ACAAGATAGAG------AAAGAA-GG-----------AACCCTCC CTAAATCATTCT-----ATGAAGCC-----AGTAT---CACCCTA-ATAC---------- ----------------------------------------C--AAAAC-------CAGGA AAG---------------------GAC---ATAACCAAAAA---AGAAAACTAC------ -------------A-GACCAATAT---CCC----TGATGAACATAGAT------------ ------------GCTAAAATCC-TTA--------------------A----CAAAATACT AGC-TAACCA------------------AA--TC--------------CA--ACA----- --------ACATATC---------AAAAAGATAATCCA--CCATGAT------------C AAG---TGGGT-TT----------CATACCA------------GG--GATGCAGGGATGG -T----------------------TT-AAC-----ATACAC--AAGTCAATAAA--TGTG ---ATACACCACAT------AAACAG----AATTAAAAACAAAAAT---CACATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTTGACAA---AATCCAGCATCGCTT- ---------------TATGA---------T---T--AA-----AACTCTCAGC---AAAA TTGGCATACAAGGGACAT-----ACCTCAATGTAATAAA--------------------- ------AGCCATCTAT-GACAAA--------CCCACAGC-----------CAACAT--AA TACTGAATGGGGA-----AAA-GTTGAAAGC----ATTC---CCT----CT--GAGAACT GGAACA----AGACAAGG-ATGC--CCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTCTTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------CAG-AC------AAGAG---AAAGA --AATAAAGGGCATCCAAATCAGT---AAAGAG------GAAGTCAAA--C--------- ------TGTCACTG-TT--T---GCTGA------TGATAT------GATCGTTTACCTA- -GAAAACC--CTAAAGA---CTCCTCCA---------A---------------AA--AGC TCCTAGAACT---------GA--TAAAAGAATTCAGCAAAG--TTT-----CCGGATAC- --AA-------------------------------AATTAA-------------TGT--- ACACAAAT----CAGT-------------------------------------------- -----AGCTCTGC--TA-TACACCAAC---------------AGCGACCAAG-----CTG A------------------GAATCAAATC-AAG----AACTCAACCCCTTTTACAATAGC TGCA------------------AAAAAAAAAAAAATAAAAAAACATAAATACTTAGGAAT ATACCT--------AA--C-CAAGGAGGTG---A---AAGACCTCT---ACAA-GGAAAA CTACAAAACAC------TGCTG-AAAGAAATCA-TA------------GATG-------- ------------ACAC--AAAC--AAA---TGGA---AA--CACAT---------CCCA- --TGCTC------ATG-GATGGGTAGAATC-A---A---TATT--------------G-- TGAAAATG-----------------------------------------ACCAT--ACTG CCA-AA--AGCAATCTACA-------------------AA---TTCAATGCA---ATC-- ------C-CCATCAAAAT--A---------------------CCACCA-TC---ATTCTT ------------------------------------------CACAGAATTAG------- ----------------------AAAAAACAAT------CCTAAAA---TTCATATGGAAC C-------AAAAAAGAGCCC---GC--ATAGCCAAAGCAAGACTAAGCA---AAAA--GA ACA---AATC--T-------GGA--GGCATCACA---TTACCTGATTTCAAACT-----A TACTAT-------------------------AA---GGCCATAGT-CACCAA---AAC-A GCA--------------TGGTACTGG--TA------------T---AAAAATAGGCA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAC-- -CCAA----------------ATA-------CTTACAG----CCAACT--GATCTTT--- GACAAA--GCAAACAAAAACATAA--A-------------------GTGGG--GA---AA GG------------ACACCCTTTT--CAACAAATGG---------------TGCTG---- ------G-GATAAT--TGG-CTAGCCA---------------CATGT-AGGAGA---ATG ---------AAACTGGATCCT---CATCT-----------CTCACC--TTA--T---ACA AAAA-TCAACT-CAAGATGG---AT---TAAGGAC---TTAAATCTA--AGACCTGAAAC TAT------------------------AAAAATTCTAGAA---------------GATAA ---CATT------G------------------G-AAAAACCCTTCTAGACATTG--GCT- -----TAGGCAAGGATT-----TCATGACCAA-GAACCCA---AAAGCAAATGCAAT--- --AAAAACA---AA----GAT---AAATAGC-TGGGAC----------CTAATT-AA--- ACTAAAAA-----G------------CTT-TTGCA-------TG--------------GC -AAAAGGAACAGT-------------CAGCAGAGTAAACAG------------------- ------A-------------CAACCC------ACAGAG--T-GGGAA---AAAATCTTC- --ACAATCTATACAT--------CC-------GACAAAGGAC--------TA--ATATC- ---CAGAATCTACAAG-GA--ACTCAA---ACA------AA--TCAGC------------ ---AAG------AA------AA--AAACA---AAC--AATCCCA-TCAA---AAAGTGGG C--TAA---------GGA--CATGA---AT---AGACAATT------------------- -----CTCAAAAGAA--------GATATAC---AA-ATGGCCAAC--AAACATATGAAAA AAT----------GCTCAACATCACTA-ATGATCA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GC---GATACCA---------CCTT----ACTCCTGCAAGAATGGCCATAAT---C A--AAAAAAT-----TAAAAAA-----ACAATA-GATG--T------------------- ------TGGC-ATGGATGTA----------GTGAA------------------------- ------------CAGGGAACACTTCT-ACACTGCTGG--TGGG----------------- ----------AATGT--A-------------AACT---CTTAC----ACCAACTATAG-- ------AAAACAGTG--TGGAG--A-TTCCTT--AAAGAACTAAAA--GTAGAACTACC- -ATTT---GA--TCCAGCAATCCCA---------------------CTACTGGG-TATC- --------------TA-CCCAGAGGAA------------AAGAAGTCA----T------- --------------TATATGAA--AAAGATACTTGC---------ACACG----CATGTT TATA--GCAGCACAATTCGCAA-TTGCAAAAACGT--G--GA--ACCA--ACCCAA---A TGCCCATCA---ATCAATG-----AGTGGATAAAG--AAAC----TG------------- ------------------------------------------------------------ ---------------------------------AAACCATTAAAAAA------------- ---ATAA----------------------------AAAGACAAGC--------------- ------------------------------------------------------------ --------CAAATAATTAGGAGATATAT---TTGTAAATTATACATTGAATAA------- --------------------------------------------AGAAATTATATCCATA ATAT-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ATAA---------------------------------ACAACTATTAA-------- ----------AAATCAATAAT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAGAA------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------TA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAA--------GCTGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAAAA------------------------------------------ ------ >L1PB1 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------ATCATGGCGGATGGGAGGCAGG ACTAGATTG---------------------------CAGCTCCG---------------- ---------------------------------------GACAGAGCAGCATGCGGAGGC TCGCATTGTGAATTTTAGCTCCAGATCGACTGCAAGAACAAAC----------------- ------------------------------------------------------------ ---------------------------------------------------------CAG CAATCCCGAGAGGACCCACAGACCCTCTGA------AGGAAGCGGAC-------TGCTCC TGCAGGACCCGGGAGACACCCCAAATACTGTGAGTGCCCCAACTGCGGAAGTGGGAAAGG GAGACCCTCCTCTC---------------------------------------------- ----------------------------------------CCGAACACACACCCCCACTG GAGAAGCTGAAGGTCTTTTGCAGGAGAAGTTTCC----------GACTTTACCTGGAGCT GAGTCAATTTAGAGAGCCGAGC------------------------------GAAATACA GGGGTAGAGGAAGCAGCAGAAAGGCCCTGGGAGCTCGCTGGGTC---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------CCCAAGCAGGCCATTCCTGCCTGGCACCA CAGGGATCCATCGGGAGGGTGGCCAGAGGAGCAGGGGGTAAAACTCCACAGGGAGAAGGA AATCTCTAGCTGAACT-------------------------------------------- ------------------------------------TTGTAACAATTTGAACGGGGTGAG AAGCCTCCTGGCCAGAACTCGGGGAGGGTGCAAATCCGGTGTGCAGACTCC--------- ------------------------------------------------------------ ---------------------------------------ACAGGCAGGGGAAGAACCAAG CCCTTTTCTTTCGCAGCTGGGAGGCGGGTAGCCTGGGGCAA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GTTTTCAAGCCCGTCTCGCCCTCCGCCTG GAAACAGACTCGGGGCTGTTGGGGGGGGCACGGTGGGAGTGAGACCGGCCCTTCGGTTTG CGTGGGAGCTGGGTGAGGCCTGTGACTGCCGGCTTTC----------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------CCCCACTTCC-------CTGACAACCTGCATGACTCAGCA GAGGCAGCCATAATCCTCCTA--------------------------------------- ------------------------------------------------------------ -------------------------------------------GGTACACAACTCCAGTG ACCTGGGAATCTCACCCCCATCCCCCACAGCAGCCGC----------------------- ------------------------------------------------------------ --------------------------------------------AGCAAGACCCGCCCAA GGAG------AGTCTGAGCTCAGACATGCCTAGCCCTGCCCCCACCTGATGGTC------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CTTCCCTACCCACCCTGGTAG CAGAAGACAAAGGG---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CATATAATCTTGGGAGTTCTAGGGCCCCGCCCA CCGCCGGTCCCTCTCCATACTACCACAGCTGATGC----TCTCTGGAAAGCGCCACCTCC T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GGCAGGAGG-----------CCAACCAGCACAAAAAT AGA--------------------------------------------------------- ------------------------------------------------------------ --------------GCATTAAACCACCAAAGCTAAGAACCCTCATGGAGTCCATTGCACC CCCCTGCC--------------------------------------ACCTCCACCGGAAC AGGCGCTGGTATCCACGGCTGAGAGACCCATAGACGGTTCACATCACAGGACTCTGTGCA GACAACCCCCAGTACCAGCCCGGAGCTGGGTAGACTCGCTGGGTGGCTAGACCCAGAAGA GAGACAACAATCACTGCAGTTTGGCTCACAGGAAGCCACATCCATAGGAAAAGGGGGAGA GTACTACATCAAGGGAACACCCCGTGGGACAAAAGAATCTGAACAACAGCCTTCAGCCCT AGACCTTCCCTCTGACAGAGCCTACCCAA--TGAGAAGGAA-----CCAGAAAACCAACC CTG-------------------------------------GTAATATGA--------CAA AACA----AGGCTCTT-------------CAAC--ACCCCCCAAA---A----------- -------ATC----ACACTAGTTC-------------------AC-CAG---CAATGGAT CCAAACC----------------AAG---AAGAAATCCCTGATTTACCTGAAAA------ ------AGAA------------TTCAGGAGGTTAGT-TATTAAGCTAATCAGGGAGGG-- --ACCAGAGAAAGGC--------------------------GAAGCCCAATGC-----AA GGAAATC----------------------------------------------------- --CAAAAAA--------------------------------------------------- -TGATACA----------AGAAGTGAAGGGAGAAATATTCAAGGAA-------------- -------------------------------------------ATAGATAGCTTAAAGAA ----------AAAA---------------CAATCAA------AAA---------TTCAG- GAAA----CTTTG---------GACAC---ACTTTTAGAAATGCGAAATGCTCTGGAA-- ---AGTCTCAGCAATAGA----------------ATTG--------------------AA C--AAGT------------------AGAAGAAAG-AAA-TTCAG--AGCTCAAAGAC--- -AAGGTCTTCGAAT-T-----AACCCAATCCA---------ACAAAGACAAA---GAAAA AAGA---ATAAGAAAA-TA---------TGA---ACAAAGCCTCC--AAGAAGTCTGGG- ATTAT--------G---TTAAACG--ACCAAACCTAAGA--A-TAATCGG--TGTT---- ----------CCTGAGG---AAGAAGAGAATTCT---AAAAGCTTGG---------AAAA CATATTT---GG-----GGGAATAATCGAG--GAAAACTTCCCCGGCCT----------- ---------TGCTAGAGACCT--AGAC--ATCCAAATAC-----AAGAAGCACAAAGA-A CACCTGGGA------------AATTCAT-CGC--------------AAAAAGATCTTCGC C-------T---------------------AGGCACATTGTCATCAGGTT------ATC- CAAAGTTAAGA---CGAAGG--AAAGAATCT----------------------------- -------------TAAGAGC--TGTGAGACA---GAAGCACCAGGT-------------- -----------AAC---CTATAAAGG-AAAACCTA--------------TCAGATT--AA CAGCAGATTTC-----TCAGCAGAA--ACCCTA-CAAGC------TAG-AAGGGATTG-- -----------GGG-CCCTATC-T-------TCAGCC--TCCT-------------CAAA CAAAA---------------CAATTA--TCA--GCCAAGAA--------TTT---TGTAT CCA-----------GCGAAACTAAGC-----ATCAT-ATATGA-------AG-------- ------------------------G-AAAGATACAGTCTTTTTCAGACAAAC-AAATGCT GAGAGA-ATTCGCCATTACCAAGC---CACCACTAC-AAGAA------------------ --------------------CTGCTAAAAGG----------------------------- -----------------------------------AGCTC--------------TAAATC TTG----------------------------------------------------AAA-- ------------------------------------------------------------ -------------------------------CAAATTCCTGGA----------------- ------------------------------------AACACAT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------CAAAA C-------------------------------------------------AGAACCTCTT TAAAGCATAA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------ATCACACAGGACCTATAAAACAAAAATACAAGTTAAAAAGCAAAAACAAA AAACAAAA---------------------------------------------------- ---------------------AAACCAAAGTAC--------------------ACAGGCA ACAAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------GAGCATGATGAATGCAATGGT--------------------- ------------------------------------------------------------ --------------------ACCTACATT--TCAATACTAAC-ATTGAAT-------G-T AAAT--GGCCT--AAATGC---TCCACTT----------------AAAAGAT------AC AGAA--CTGCAG----AATG---------GAT-------AAGA---ACTCACCAACCAA- ---CTA-------TCT-GCTGCCTT-CAGGAGACTCACCT-AACAC--ATAAGGACTCAC A-TAAACTTAAAGTAAAGGGG---T------------GGAAA----A-AGGCATTTCATG C--------------AAATGG------ACACC---------------------AAAAG-C GAGCAG--GGGT----AGCTATTCTTATATC-AGACAAAACAAACTTTAAA-GC------ ----AACAGCAG---TTAAAAGAGAC-AAAG-AGGGACAT------TATAT------AAT GGTAAA---AGGCCTTGTC------CAACAG---GAAA--------AT-ATCACAA-TCC TAA-----------------A----CATATATG---------CACCTAACACTGGAGCTC CCAA--ATT-TATAAAACAATTACTAATAGACCT--AA----GAAATGA---------GA TAGACAGCAAC------ACAATAATAGTGGGGGACTTCAATA----------------CT CCACT------GACAGC-ACTAGACAGGTCAT---------------------CAAGAC- -----AGAA-------------AGTCAACAAAGAAACAATGGATTTAAAC-TATACCTTG GA------ACAAATGG---ACTTAACAGATATATACA--GA----ACATTTCATCCAACA AC---CACAGAATACACAT------TCTATTCAACAG-----CG--CAT-GGAACTTTCT --C----CAAGATAGACCATATGATAGGCCATAAAATGAG-------------------- -CCTCAATAAATTTAAGAAAA--TTGAAAT----------------TATATCAA------ -GCACTCTCTCA---GACCACAGTGGAA-TAAAACTGGAAATCAAC-------------- ----------------------------------------------TCCA--------AA --------------AGG-AACCTTCA---AAACCATGCAA----ATACATGGAAA--T-T AAATAACCTG-CTCCTGAA---TG-AGCATTG--GGTCAAAAACGA--AAT--C-AAGAT GGAAATT---------------AAAAAATTCTTT---GAACT------------------ ------GAATGACAATAA-TGA------------CACAAC--CTATCAAAACCTC-TGG- GA-----TACAGCAAAGGCGGTG-----------------------------CTAAGAGG AAAG--TTCATAGCCCTA----AATGC----CTACATCAAAAAGA---CTGAAAGAGCA- --CAAACTGAC-AATCTAA-GGTCACACCTC---AAGGAAC--TAGAGAAAC------AA GA-----ACAAACCAAAC-------------CCAAACC--CAGCAGAA-GAAAGGAAATA ACC---AAGATCAGA-------------------GCAGAACTA---AA-T-GAAATTGAA ACAAACAAAAAAA------------------------------------AAA-------T ACAAAAGATA-A---------ATG----AAACAA-AAAGCTG------GTTCTTTGAAAA GATAAA------------------------------------------------------ --------------------------------TAA-----AATTGATAGACCA---TTAG CAA------GATTAA--CCA------------AGAAA------------------AGAAG A---GAGA-AAATCC-----------------AAATAAC--------CTCAC-----TA- ---------AGA-AATGAAA--CA----------GGAGA---TATTACAACTGACACC-A CT-GAAATA--CAAAAGAT-CATTCA---------AGGCTACT--ATGAA---------- -----------CAC---CTTTACGCACATAA---ACTAGAAAACCTAG---AAGAGAT-- GGATAAATTCCT----------GGAAAAA---------TAC-----AACCCTCCT----- -AGCTTAAATCA---GGAAGAATTAGATACCCTGAAC----------------------- AGACC------------AA-TAACAAGCAGCGAGATTGAAA-T---------GGTAAT-- -TTAAAA-TTACC------AACAAAAAAAAG---TCCAGGACC--AGATGG--------- ------------ATTCACA-GCAG--AA-------------------TTCTA-------- ----CCAGACATTC---AAAGAA-GAATTGG--TA-CCAATC----------CTTTTGAC ACTATT----CC---ACAAGATAGAG------AAAGAA-GG-----------AACCCTCC CTAATTCATTCT-----ATGAAGCC-----AGCAT---CACCCTA-ATAC---------- ----------------------------------------C--AAAAC-------CAGGA AAG---------------------GAC---ATAACCAAAAA---AGAAAACTAC------ -------------A-GACCGATAT---CCT----TGATGAACATAGAT------------ ------------GCTAAAATCC-TTA--------------------A----CAAAATACT AGC-TAACCG------------------AA--TC--------------CA--ACA----- --------ACATATC---------AAAAAGATAATCCA--CCATGAT------------C AAG---TGGGT-TT----------CATACCA------------GG--GATGCAGGGATGG -T----------------------TT-AAC-----ATACGC--AAGTCAATAAA--TGTG ---ATACACCACAT------AAACAG----AATTAAAAACAAAAAT---CACATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTCGACAA---AATCCAGCATCCCTT- ---------------TATGA---------T---T--AA-----AACTCTCAGC---AAAA TCGGCATACAAGGGACAT-----ACCTTAATGTAATAAA--------------------- ------AGCCATCTAT-GACAAA--------CCCACAGC-----------CAACAT--AA TACTGAATGGGGA-----AAA-GTTGAAAGC----ATTC---CCT----CT--GAGAACT GGAACA----AGACAAGG-ATGC--CCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTCTTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------CAG-AC------AAGAG---AAAGA --AATAAAGGGCATCCAAATCGGT---AAAGAG------GAAGTCAAA--C--------- ------TGTCACTG-TT--T---GCTGA------TGATAT------GATCGTTTACCTT- -GAAAACC--CTAAGGA---CTCCTCCA---------G---------------AA--AGC TCCTAGAACT---------GA--TAAAAGAATTCAGCAAAG--TTT-----CCGGATAC- --AA-------------------------------GATTAA-------------TGT--- ACACAAAT----CAGT-------------------------------------------- -----AGCTCTTC--TA-TACACCAAC---------------AGCGACCAAG-----CAG A------------------GAATCAAATC-AAG----AACTCAACCCCTTTTACAATAGC TGCA------------------AAAAAAATA---------AAA------TACTTAGGAAT ATACCT--------AA--C-CAAGGAGTCG---A---AAGACCTCT---ACAA-GGAAAA CTACAAAACAC------TGCTG-AAAGAAATCA-TA------------GATG-------- ------------ACAC--AAAC--AAA---TGGA---AA--CACAT---------CCCA- --TGCTC------ATG-GATGGGTAGAATC-A---A---TATT--------------G-- TGAAAATG-----------------------------------------ACCAT--ACTG CCA-AA--AGCAATCTACA-------------------AA---TTCAATGCA---ATC-- ------C-CCATCAAAAT--A---------------------CCACCA-TC---ATTCTT ------------------------------------------CACAGAATTAG------- ----------------------AAAAAACAAT------TCTAAAA---TTCATATGGAAC C-------AAAAAAGAGCCC---GC--ATAGCCAAAGCAAGACTAAGCA---AAAA--GA ACA---AATC--T-------GGA--GGCATCACA---CTACCTGATTTCAAACT-----A TACTAT-------------------------AA---GGCCATAGT-CACCAA---AAC-A GCA--------------TGGTACTGG--TA------------T---AAAAATAGGCA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAC-- -CCAA----------------ATA-------CTTACAG----CCAACT--GATCTTC--- GACAAA--GCAAACAAAAACATAA--A-------------------GTGGG--GA---AA GG------------ACACCCTTTT--CAACAAATGG---------------TGCTG---- ------G-GATAAT--TGG-CTAGCCA---------------CATGT-AGGAGA---ATG ---------AAACTGGATCCT---CATCT-----------CTCACC--TTA--T---ACA AAAA-TCAACT-CAAGATGG---AT---TAAGGAC---TTAAACCTA--AGACCTGAAAC TAT------------------------AAAAATTCTAGAA---------------GATAA ---CATT-------------------------GGAAAAACCCTTCTAGACATTG--GCT- -----TAGGCAAGGATT-----TCATGACCAA-GAACCCA---AAAGCAAATGCAAT--- --AAAAACA---AA----GAT---AAATAGC-TGGGAC----------CTAATT-AA--- ACTAAAGA-----G------------CTT-TTGCA-------CG--------------GC -AAAAGGAACAGT-------------CAGCAGAGTAAACAG------------------- ------A-------------CAACCC------ACAGAG--T-GGGAG---AAAATCTTC- --ACAATCTATACAT--------CT-------GACAAAGGAC--------TA--ATATC- ---CAGAATCTACAAC-GA--ACTCAA---ACA------AA--TCAGT------------ ---AAG--------------AAAAAAACA---AAC--AATCCCA-TCAA---AAAGTGGG C--TAA---------GGA--CATGA---AT---AGACAATT------------------- -----CTCAAAAGAA--------GATATAC---AA-ATGGCCAAC--AAACATATGAAAA AAT----------GCTCAACATCACTA-ATGATCA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GC---GATACCA---------CCTT----ACTCCTGCAAGAATGGCCATAAT---C A--AAAAA-------TCAAAAA-----ACAGTA-GATG--T------------------- ------TGGC-GTGGATGCG----------GTGAA------------------------- ------------CAGGGAACACTTCT-ACACTGCTGG--TGGG----------------- ----------AATGT--A-------------AACT---AGTAC----AGCCACTATGG-- ------AAAACAGTG--TGGAG--A-TTCCTT--AAAGAACTAAAA--GTAGAACTACC- -ATTT---GA--TCCAGCAATCCCA---------------------CTACTGGG-TATC- --------------TA-CCCAGAGGAA------------AAGAAGTCA----T------- --------------TATTCGAA--AAAGATACTTGC---------ACACG----CATGTT TATA--GCAGCACAATTCACAA-TTGCAAAATCGT--G--GA--ACCA--ACCCAA---A TGCCCATCA---ATCAACG-----AGTGGATAAAG--AAAC----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAT----ATATGATGGAATAC-----T--ACTCA GCCATAA----AA----------------------AGGAATGAATTAACAGCATTT---- ------------------------------------------------------------ --------GCAGTGACCTGGATGAGA-T---TGGAGACTATTATTCTAAGTGA------- ------------------------------------------------AGTAACTCAGGA ATGG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAACAT-CG-------- ---TAT---GTTCTCACTGAT----------ATGTGGGAGCC------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TAAGCTATGAGGACGCAAA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------GGCATA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------ATGATAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AATGGAC-----------------------------------------------T TTG-------GGGACTTGGG----------------------GGGAAGAGTGGGAGGG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------GGGCGAGGGATA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------AAAGACTACAAATATGGTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------CAGTGTATACTG----------------------------- ---------------CTCGGGTGATGGGTGCACCAAAATCTCACAAATCACCACTA---- ------------------------------------------------------------ ------------------------------------------------------------ -AAGAACTTACTCATGT------------------------------------------- --------------------------------------------AACCAA---------- -------------ATACCACCTGTACCCCAA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TAACTTATG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GAAAAATAA------------------------------------------ ------ >L1ME4A ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAA-----------------ATGGCGGATGGGAGACAGG ACTAGATTG---------------------------CAGCTCCCACTCAGATA------- ---------------------------------------GACAGAGCAGCATGCAGAAGC TCACATTTTTAACTTTTGCCCCAAGATCAACTGCAGGAACATA----------------- ------------------------------------------------------------ --------------------------------------------------------CCAG GAAAACTGAGAGGGCCCACAGACCCTCTGA------AGGAAGCAGAC-------TGGTCC TGCAGGACCCAGGAGACACCCCAAATACTGCAAG---------TGCCGAAGTTGGAAAGG GACACCCTTCTCTC---------------------------------------------- ----------------------------------------CCGATCACACACACACCACT GGAGAAGCTGAAGGTCTGTTTGTGGGAGATGTTT-----CT---GACTTTACCTGGAGCT GAGTCAATTTAGAGAGCCAAG-------------------------------CAAAATAC AGAGGAGAGGAAGCAGCAGAAAGACCCTGGGGGCTCACTGCA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------CCCCCTAGCAGCCCATTCCTGCCTGGCAC CACAGGTATCCATCAGGAGGGTGACCAGAGGAGCAAGGGGTAAACCACAGGGAGAAGGAA ATCTCTAGCTGAACTT-------------------------------------------- -------------------------------------TGTAACAATTTGAACAGGGCAAG AAGCCTCCTGGCCAGAACTCATGGGAGGGCG--------------AAAATCTGGTGTGCA GACTCC------------------------------------------------------ ---------------------------------------ACAGGTGGGGGAAGAACCAAG CCCTTTTCTTTTGCAGCTGGGAAGAGGATAGCCCAGGGCAA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------GTTTTCAGCCCCTCACGCCCTCCGCCAG GAAACAGACTCTGCGCTGTTGGAGGGGACACAGTGGGAGTGAGACTGGCCCCTTGGTTTG CATGGGAGCTGGGTGAGGCCTGTGACTGCCGGCTTTC----------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------CCCCACTTCC-------CTGACAACCAGCATGACTCAGCA GAGGCAGCCATAATCCTCCTAGGTACAC-------------------------------- ------------------------------------------------------------ -------------------------------------------------AACTCTAGTGA CCTGGGAATCTCACACCCATACCTCACAGCAGCTGC------------------------ ------------------------------------------------------------ --------------------------------------------AGCAAGACCCGCCCAA GGAG------AGGCTGAGCTCAGATACACCTAACCCCGCAACCACCTGATGGTC------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TTTCCCTACCCACCCTGGCAG CGGAAGACAAAAGACATAATATCTTGGGAGTTCTAGGGTCCCCGCCCTCAACCTGAGAAA GCTGAGTGCTCCTCCAGGTGACCGTAGGGGAAGGT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----TGTATCCTCCCCATACTACTACAGCTGATGCTTTCTTGAAAGCGCCCCCCCCCTGG ATGAAGCCTACCAAAACCAAACTGTAACATAGCAACT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------CATAAAAGAACAACACTGCCCCAAGAAAGGAGAAAAC AACAGCTAATTTCACCACCTGTAACATCCTGGCTAACCAGAGGTCCTGAGTCTTTCCATG TGACAACTTTACTGCCAGCACAACCAGCATTCAAGAAAAGCAGTGC-------------- --------------ACTAAACAAAACCATAGCTAAGAACCCTCATGGAGTCCATTTCACA CCCCGGCT--------------------------------------ACCTCCACCGGAGC AGGTGCTGGTATCCATGGCTGAGAGACCCATAGATGGTTCACATCACAGGACTCTGTGCA GACAACCCCCAGTACCAGCCCAGAGCCTGGTAGCCTTGCTGGGTGGCTAGACCCAGAAGA GAGATAACAATCACTACAACTCGGCTCTCAGGAAGCCACATCCATTAGGAAAAGGGGGAG AGTACTACATCAAGGGAACACCCCATGGAACAAAAGAATCTGAACAACAGACCTTCAGCC CTAGACCTTCCCTCTGACAGAGCCTACCCAATGAGAAGGCA-----CCAGAAAACCAACT CTG-------------------------------------GTAATATGA--------CAA AACA----AGGTTCTT-------------TAAC--ACCC--CCAA---A-AA-------- -------ATC----ACACTAGCTC-------------------AC-CAG---CAATGGAT CCAAATC----------------AAA---AAGAAATCCCTGATTTACCTGAAAA------ ------AGAA------------TTCAGGAGGTTAGT-TATTAAGCTAATCAGGGAGGC-- --ACCAGAGAAAGGT--------------------------GAAGCCCAATGT-----AA GGAAATC----------------------------------------------------- --CAAAAAA--------------------------------------------------- -TGATACA----------AGAAGTGAAGGGAGAAATATTCAAGGAA-------------- -------------------------------------------ATAGATAGCATAAATAA ----------AAAA---------------CAATCAA------AAC---------TTCAG- GAAA----CAATG---------GACAC---ACTTATAGAAATGCAAAATGCTCTGGAA-- ---AGTCTCAGCAATAGA----------------ATTG--------------------AA C--AAGT------------------GGAAGAAAG-AAA-TTCAG--AGCTTGAAGAC--- -AAGGTTTTCGAAT-T-----AACCCAATCCA---------ACAAAGACAAA---GAAAA AAGA---ATAAGAAAA-TA---------TGA---ACAAAGCCTCC--AAGAAGTCTGGG- ATTAT--------G---TTAAACG--ACCAAACCTAAGA--A-TAATTGG--TGTT---- ----------CCTGAGG---AAGAAGAGAAATCT---AAAAGTTTGG---------AAAA CATATTT---GG-----GGGAATAATCGAG--GAAAACTTCCCTGGCCT----------- ---------TGCTAGAGACCT--AGAC--ATCCAAATAC-----AAGAAGCACAAAGA-A CACCCGGGA------------AATTCAT-TGC--------------AAAAAGATTATCGC C-------T---------------------AGGCACATTGTCATCAGGTT------ATC- TAAAGTTAAGA---CGAAGG--AAAGAATCT----------------------------- -------------TAAGAGC--TGTGAGACA---AAAGCACCAGGT-------------- -----------AAC---CTATAAAGG-AAAACCTA--------------TCAGATT--AA CAGCAGATTTC-----TCAGCAGAA--ACCCTA-CAAGC------TAG-AAGGGATTG-- -----------GGG-CCCTATC-T-------TCAGCC--TCCT-------------CAAA CAAAA---------------CAATTA--TCA--GCCAAGAA--------TTT---TGTAT CCA-----------GTGAAACTAAGC-----TTCAT-AAATGA-------AG-------- ------------------------G-AAAGATACAGTCTTTTTCAGACAAAC-AAATGCT GAGAGA-ATTCACCACTACCAAGC---CACCACTAC-AAGAA------------------ --------------------CTGCTAAAAGG----------------------------- -----------------------------------AGCTC--------------TAAATC TTG----------------------------------------------------AAACA AATC-------------------------------------------------------- -------------------------------CTCTTTAAAGCA----------------- ------------------------------------TAAATCT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CACAGGACC-------------------------TATAA A-------------------------------------------------ACAATAATAC AAGT-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TAAAAAACAAACA-------------AGGTATACAGGCA ACAAA------------------------------------------------------- ------------------------------------------------------------ -------------TAGCATG---------------------------------------- ------------------TGAAT-------GGAACAGTA--------------------- ------------------------------------------------------------ --------------------CCTCACATC--TCAATACTAAC-ATTGAAT-------G-T AAAT--GGCCT--AAATGC---TCCACTT----------------AAAAGAT------AC AGAA--CTGCAG----AATG---------GAT-------AAGA---ATTCACCAACCAA- ---CTA-------TCT-GCTGCCTT-CAGGAGACTCACCT-AACAC--ATAAAGACTCAC A-TAAACTTAAAGTAAAAGGA---T------------GGAAA----A-AGGCATTTCATG C--------------AAATGG------AAACC---------------------AAAAG-A GAGCAG--GGGT----AGCTATTCTTATATC-AGACAAAACAAACTTTAAA-GC------ ----AACAGCAG---TTAAAAAAGAC-AAAG-AGGGACAT------TATAT------AAT GGTAAA---AGGCTTTGTC------CAACAG---GAAA--------AT-ATCACAA-TCC TAA-----------------A----CATATATG---------CACCTAACACTGGAGCTC CCAA--ATT-TATAAAACAATTACTAATAGACCT--AA----GAAATGA---------GA TAGACAGCAAC------ACAATAATAGTGGGGGACTTCAATA----------------CT CCACT------GACAGC-ACTAGACAGGTCAT---------------------CAAGAC- -----AGAA-------------AGTCAACAAAGAAACAATGGATTTAAAC-TATACCTTG GA------ACAAATGG---ACTTAACAGATATATACA--GA----ACATTTCATCCAACA AC---CACAGAATACACAT------TCTATTCAACAG-----TG--CAT-GGAACTTTCT --C----CAAGATAGACCATATGATAGGCCACAAAATGAG-------------------- -CCTCAATAAATTTAAGAAAA--TTGAAAT----------------TATATCAA------ -GCACTCTCTCA---GACCACAGTGGAA-TAAAACTGGAAATCAAC-------------- ----------------------------------------------TCCA--------AA --------------AGG-AACCTTCA---AAACCATGCAA----ATACATGGAAA--T-T AAATAACCTG-CTCCTGAA---TG-ATCATTG--GGTCAAAAATGA--AAT--C-AAGAT GAAAATT---------------AAAAAATTCTTT---GAACT------------------ ------GAATGACAATAG-TGA------------CACAAC--CTATCAAAACCTC-TGG- GA-----TACAGCAAAGGTGGTG-----------------------------CTAAGAGG AAAG--TTCATAGCCCTA----AATAC----CTACATCAAAAAGA---CTGAAAGAGCA- --CAAACTGAC-AATCTAA-GGTCACACCTC---AGGGAAC--TAGAGAAAC------AA GA-----ACAAACCAAAC-------------CCAAACC--CAGCAGAA-AAAAGGAAATA ACC---AAGATCAGA-------------------GCAGAACTA---AA-T-GAAATTGAA ACAAA------AA------------------------------------AAA-------T ACAAAAGATA-A---------ATG----AAACAA-AAAGTTG------GTTCTTTGAAAA GATAAA------------------------------------------------------ --------------------------------TAA-----AATTGATAGACCA---TTAG CAA------GATTAA--CCA------------AGAAA------------------AGAAG A---GAGA-AAATCC-----------------AAATAAC--------CTCAA-----TA- ---------AGA-AATGAAA--CG----------GGAGA---TATTACAACTGACATC-A CA-GAAATA--CAAAAGAT-CATTCA---------AGGCTACT--ATGAA---------- -----------CAC---CTTTATGTGCATAA---ACTAGAAAACCTAG---AAGAAAT-- GGATAAATTCCT----------GGAAAAA---------TAC-----AACCCTCCT----- -AGTTTAAATCA---GGAAGAATTAGATACCCTGAAC----------------------- AGACC------------AA-TAACAAGTAGCAAGATTGAAA-T---------GGTAAT-- -TAAAAAAATACC------AATAAAAAAAAG---TCCAGGACC--AGATGG--------- ------------ATTCACA-GCAG--AA-------------------TTCTA-------- ----CCAGACATTC---AAAGAA-GAATTGG--TA-CCAATC----------CTATTGAC ACTATT----CC---ACAAGATAGAG------AAAGAA-GG-----------AACCCTCC CTAATTCATTCT-----ATGAAGCC-----AGTAT---CACCCTA-ATAC---------- ----------------------------------------C--AAAAC-------CAGGA AAG---------------------GAC---ATAACCAAAAA---AGAAAACTAC------ -------------A-GACCAATAT---CCC----TGATGAACATAGAT------------ ------------GCTAAAATCC-TTA--------------------A----CAAAATACT AGC-TAACCA------------------AA--TC--------------CA--ACA----- --------GCATATC---------AAAAAGATAATCCA--CCATGAT------------C AAG---TGGGT-TT----------CATACCA------------GG--GATGCAGGGATGG -T----------------------TT-AAC-----ATACAC--AAGTCAATAAA--TGTG ---ATACACCACAT------AAACAG----AATTAAAAACAAAAAT---CACATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTCAACAA---AATCCAGCATTCCTT- ---------------TATGA---------T---T--AA-----AACTCTCAGC---AAAA TTGGCATACAAGGGACAT-----ACCTCAATGTAATAAA--------------------- ------AGCCATCTAT-GACAAA--------CCCACAGC-----------CAACAT--AA TACTGAATGGGGA-----AAA-GTTGAAAGC----ATTC---CCT----TT--GAGAACT GGAACA----AGACAAGG-ATGC--CCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTCTTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------CAG-AC------AAGAG---AAAGA --AATAAAGGGCATCCAAATCAGT---AAAGAG------GAAGTCAAA--C--------- ------TGTCACTG-TT--T---GCTGA------TGATAT------GATCATTTACCTT- -GAAAACC--CTAAAGA---CTCCTCCA---------G---------------AA--AGC TCCTAGAACT---------GA--TAAAAGAATTCAGCAAAG--TTT-----CTGGATAC- --AA-------------------------------AATTAA-------------TGT--- ACACAAAT----CAGT-------------------------------------------- -----AGCTCTTC--TA-TACACCAAC---------------AGCGACCAAG-----CAG A------------------GAATCAAATC-AAG----AACTCAACCCCTTTTACAATAGC TGCA------------------AAAAATAAA---------AAAAAAAAATACTTAGGAAT ATACCT--------AA--C-CAAGGAGGTG---A---AAGACCTCT---ACAA-GGAAAA CTACAAAACAC------TGCTG-AAAGAAATCA-TA------------GATG-------- ------------ACAC--AAAC--AAA---TGGA-------AACAT---------CCCA- --TGCTC------ATG-GATGGGTAGAATC-A---A---TATT--------------G-- TGAAAATG-----------------------------------------ACCAT--ACTG CCA-AA--AGCAATCTCCA-------------------AA---TTCAATGCA---ATC-- ------C-CCATCAAAAT--A---------------------CCACCA-TC---ATTCTT ------------------------------------------CACAGAATTAG------- ----------------------AAAAAACAAT------TCTAAAA---TTCATATGGAAC C-------AAAAAAGAGCCT---GC--ATAGCCAAAGCAAGACTAAGCA---AAAA--GA ACA---AATC--T-------GGA--GGCATCACA---TTACCTGACTTCAAACT-----A TACTAT-------------------------AA---GGCCATAGT-CACCAA---AAC-A GCA--------------TGGTACTGG--TA------------T---AAAAATAGGCA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAC-- -CCAA----------------ATA-------CTTACAG----CCAACT--GATCTTC--- GACAAA--GCAAACAAAAACATAA--A-------------------GTGGG--GA---AA GG------------ACACCCTTTT--CAACAAATGG---------------TGCTG---- ------G-GATAAT--TGG-CTAGCCA---------------CATGT-AGGAGA---ATG ---------AAACTGGATCCT---CATCT-----------CTCACC--TTA--T---ACA AAAA-TCAACT-CAGGAGG----AT---TAAGGAC---TTAAACCTA--AGACCTGAAAC TAT------------------------AAAAATTCTAGAA---------------GATAA ---CATT-------------------------GGAAAAACCCTTCTAGACATTG--GCT- -----TAGGCAAGGATT-----TCATGACCAA-GAACCCA---AAAGCAAATGCAAT--- --AAAAACA---AA----GAT---AAATAGC-TGGGAC----------TTAATT-AA--- ACTAAAGA-----G------------CTT-TTGCA-------AC--------------GC -CAAAGGAACAGT-------------TAGCAGAGTAAACAG------------------- ------A-------------CAACCC------ACAGAG--T-GGGAG---AAAATCTTC- --ACAATCTATACAT--------CT-------GACAAAGGAC--------TA--ATATC- ---CAGAATCTACAAC-AA--ACTCAA---ACA------AA--TCAGC------------ ---AAG--------------AAAAAAACA---AACT-AATCCCA-TCAA---AAAGTGGG C--TAA---------GGA--CATGA---AT---AGACAATT------------------- -----CTCAAAAGAA--------GATATAC---AA-ATGGCCAAC--AAACATATGAAAA AAT----------GCTCAACATCACTA-ATGATCA------------------------- -----GGGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GT---GATACCA---------CCTT----ACTCCTGCAAGAATGGCCATAAT---T A--AAAAA-------TTAAAAA-----AACAGA-GATG--T------------------- ------TGGC-ATGGATGCG----------GTGAT------------------------- ------------CAGGGAACACTTCT-ACACTGCTGG--TGGG----------------- ----------AATGT--A-------------AACT---AGTAC----AACCACTGTGG-- ------AAAACAGTG--TGGAG--A-TTTCTT--AAAGAACTAAAA--GTAGAACTACC- -ATTT---GA--TCCAGCAATCCCA---------------------CTACTGGG-TATC- --------------TA-CCCAGAGGAA------------AAGAAGTCA----T------- --------------TATATGAA--AAAGATACTTGC---------ACA------CATGTT TATA--GCAGCACAATTCACAA-TTGCAAAATCAT--G--GA--ACCA--ACGCAA---A TGCCCATCA---ATCAAAG-----AGTGGATATAG--AAAC----TG------------- ------------------------------------------------------------ ------------------------TGTAT------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >L1PA17 ------------------------------------------------------------ ------------------------------------------------------------ ------------TTTTTTTCCAAG-----------------ATGGCTGACTAGGGACATC AGATGCTCG---------------------------CCATTCTCTGAAAG---------- ---------------------------------------GGGATCTAAGTTATCGG---- -TTAAAGTACCAGTTTTGGA---TGGTAAACTGTGG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAA------GAGAGCCAGGA-------GATGGC GGCGTGCCCATGGGAAAAACCTGGGGTGTAGAAA---------G-GGAAAGCTGAGAGAG CTTGGC----------------------------------------------------GG AGA-------------------------------------CACACTGCGTTGGGCCCCGG AGGCGCCCAGAGACCCTACTGAAGGGAAGAGTGC-----GG---GGGGGATCCTCGCTGC TCCGCATTCCGCCCCC------------------------------------GCCCCCCG CCTATGGCTCAACTGGTAGTGCGCACCTCTGCCCACCTAACCCAGGGTAGCATTGTTGGT GGCGAT---------------------------------------TGGGGAACTTGCCGA GAAAACAGGAACCGGTTGCCTGGTCTTGCGGGCAGGATGTGGCTCGCTCCTCGCCTCCCG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------CGTCCGGCGTTGTC----CTGTGTGCTGCG CAGCAGTAGTTCCTAGGGGGTGCATCTCTCCTGCACGGCGGTACTCCCCCCTTGAGACAC CGCACGACCATAGCCC-------------------------------------------C CGTAAACATACCTCACAACTTGCTCTCACTTTGGCGACCTCAGGGTGCCTGCGGGACCCT GGGGGCCCGCTGTGCGGACTAGGAGGGTGGGA-------------GTCTCCGGTCCCCTG GAGATCTAACCCTCGGTGTGGACTGCCCCTAAGG----------------------GAGG GGGGGGTGCAGCCCC------------CCAAAGCCC---CCCTTGGGTCAAAGGAAATGT GG---GTGTGGCGCCAGCCGCTGAAGGGGGCACCACCAAAG------------------- ------------------------------------------------------------ ----CCTGGGAATGGACATGGAGAGGGGGTGGGGGGTTCT-------------------- ------------------------------------------------------------ ----------------------------------------CCCCTTCCCCCCCCCCCC-- ---------CCTCCTCAGTGCACTGTTGCGGATTCGGCAGTGGCTCTTCCCACTGGGGCC TGGTGAGCGTGGGCTGGAAAAGGCTG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------CTTCTCAGGC-------TTCTCCAGTGGCTCCACCCCCGC TGAAGGTGAATACGAGCTGGCGGGGGCC--------------------------TTTTTC CTGGTTTCTGCTTTGCCCCCCCCCCCTACACAGAG------------------------- -TCACAGCACCAGGGCCCTGGCAAGAAAGGGCGGACATGCCCCGGAGTTGCCTGCCCTCG ACAGG-GGGAAGCTGCTCTGCCCTCCACCCATTTT------------------------- ------------------------------------------------------------ ---------------------------------------------GCTGGTGGCCCCCAG GGGGGACTATCCACTGCCCACGGCCTACCGCCAGCCTGGGGCCGGGAACCAAGGGCCAGA A----------------------------------------------------------- -----------------------------------------------------------G CCATG-----------------TGACTTGAAG-------GACATGCGCGCCCCGTGACAG GGGTGTGATAGGGA--------------------------------AGTGGATTGCCCTC TT------------GCTGGCTCAGGATGAGGAGCTGGTGCACC----CCCCCCCCCCATT CCCCCCAA---------------ACCTTCCCCCCTGCCTTTCCCCTCCCCTGCCTCCCTT CTGCTCCTCTCCCCCCCCCATCGAGAGCAGAATTTGCAGG-------------------- ---TTTCATCTGCCTACGACCCTATCTGCTGGCTC----TTACTCTTAAGTGCCATCTAC TGGACTGCAGCCTGAATT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------ACA-----------CCACCAAACAAAAATA- ------------------------------------------------------------ ------------CATTGCTACAACAAGCAATATCTGAGAAAGCCACT------------- --G-----------CATGAACCTATCTGCAACCAGGAACCCGTACAGAGCCTTGGCCCTC --------TGAAAGCACCCAGAAATGAAGCCAATCGATTATACACAACATACACCACA-- --------------------------------GTCAT--ACCCTCAAGGGA--------- ---------AAAAA---------------------------------------------- -GAATAAAAAATCAAAAAGCCCCATCCAAATGATAGCAAATTC----------------- ------------------------------------------------------------ -------------------------------AAAAAAAAAA-----AAAAAAAAAAAAAG AAGCATCAGCTCCCTCAGTAAGAACTCAG-----------GCAATACAA--------AAA GCCA----GAGTGTTT-------------AAAC--ACCT--CCAA---A-GG-------- -------ATC----CCACTAGCTC-------------------CC-TAG---CAATGGAT CCTAACC----------------AGA---ATGAAATGTCTGAAATGACAGATAT------ ------AGAA------------TTCAGAATATGGAT-GGCAAGGAAACTCAATGAGAT-- --CCAAGAGAAAGTT--------------------------GAAATCCAATAC-----AA AGAAACC----------------------------------------------------- --AGAAAAA--------------------------------------------------- -TAATCCA----------AGATTTGAAAGATAAC-------------------------- -------------------------------------------ATAGCTATATTAAGAAA ----------GAAC---------------CAAACAG------AAC---------TTCTG- GAAA----TGAAA---------AATTC---ACTAAAGGAATTTCAAAATACAGTTGGA-- ---AGCTTTAACAATAGA----------------CTAG--------------------AC C--AAGC------------------AGAAGAAAG-AAT-TTCAG--AGCTTGAAGAC--- -TAGTCTTTCAAAT-T-----AACCCAGTCAA------------AAAATAAA---GAAAA AAGA---ATTTTAAAA-AA---------TGA---ACAAAGCCTTT--GAGAAATATGGG- ATTAT--------G---TAAAGTG--ACCAAACCTATGA--C-TTATTGG--CATT---- ----------CCTGAGA---GAGAAGAAAAAGTA---AGCAACTTGG---------AAAA CATATTT---GA-----GGGAATAATTCAG--GAAAATTTCCCTAATCT----------- ---------TGCTAGAGAGGT--AGAC--ATCCAGATAC-----AAGAAATTCAGAGA-A CACCTGCAA------------GATACTA-TAC--------------AAGATGACCATCCC C-------A---------------------AGGCACATAGTCATCAGACT------ATC- CAAGGTCAATG---TAAAAG--AAAAAATCT----------------------------- -------------TAAAGGC--AGCTAGAGA---AAAGGGTCAAAT-------------- -----------TAC---CTATAAAGG-AAATCCCA--------------TCAGACT--AA CAGCAGACTTC-----TCAGCAGAA--ACCTTA-CAAGC------CAG-AAGAGATTG-- -----------GGG-GTCTATT-T-------TTAGCC--TTCT-------------TAAA AAAAA---------------AAAATG--CCA--GCCAAGAA--------TTT---TATAT CCT-----------GCCAAACTAAGC-----TTCAT-AAATGA-------AG-------- ------------------------G-AGAAATAAAGTCTTTCCCAGACAAGC-AAATGCT AAGGGA-ATTTATCACCACCAGAC---CAGCCCTAC-AAGAA------------------ --------------------ATGCTCAAAGG----------------------------- -----------------------------------AGTTC--------------TAAACA TGG----------------------------------------------------AAATG AAAG---------------AAAAATA---------------------------------- -------------------------------CATTCTCCCACA----------------- ------------------------------------AAAACAC----------------- --------AATGAAAGAATGATACTGCTACCACAAAAG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------CACACATAAGTA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------CATA------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GC-------- --------------------CCACAGACCC-------------------------TATAA A-------------------------------------------------GCAACTACAC ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AATTGAGACTACA--------------AA---GCAACTA GCTAA------------------------------------------------------- ------------------------------------------------------------ -------------CAACACT---------------------------------------- ------------------TGACA-------GGAACAAAA--------------------- ------------------------------------------------------------ --------------------CCTCACATA--TCAATATTAAC-CTTGAAT-------G-T AAAT--GGCCT--AAATGC---TCCACTT----------------AAAAGAC------AT AGAG--TGGCAA----ATTG---------GAT-------TAAA---AAACAAGACCCAA- ---CCT-------TCT-GCTGCCTT-CAAGAGACCCATCT-CACAT--GTAATGACACCC A-TAGGCTCAAAGTAAAGGGA---T------------GGAGA----A-AGATCTATCATG C--------------AAATGG------AAAAC---------------------AAAAA-A GAGCAG--GGGT----TGCTATTCTTGTATC-AGATAAAACAGACTTTAAA-CC------ ----AACAACAG---TAAAAAAAGAC-AAAG-AAGGGCAT------TATAT------AAT GATTAA---AGGTTCAATA------AGACAA---GAAG--------AT-TTAACTA-TCC TAA-----------------A----TATATATG---------CACCCAACATTGGAGCAC CCAG--ATT-TATAAAACAAATACTACTAGACCT--TA----GAAAAGA---------GA TAGATAGCCAT------ACAATAATAGTGGGGGACTTCAACA----------------CC CCACT------GACAGC-ACTAGACAGATCAT---------------------TGAGGC- -----AGAA-------------AACTAACAAAGAAACTCTGGACTTAAAT-TGGACTCTT GA------CCAAATGG---ACCTAATAGACATCTACA--GA----ATACTCCACCCAACA AC---CACAGAATATACAT------TCTTCTCATCTG-----CA--CAT-GGAACATTCT --C----TAAAATTGACCACATGCTTGGTCATAAAGCAAG-------------------- -TCTCAATAAATTCAAAAAAA--TTGAAAT----------------CATATCAA------ -GCATCTTCTCA---GACCACAGTGGAA-TAAAATTAGAAATCAAT-------------- ----------------------------------------------ACCA--------AG --------------AGG-AACTCTCA---AAACCACACAA----ATACATGGAAA--C-T AAACAACTTG-CTCCTGAA---TG-ACTTTTG--GGTAAACAATAA--AAT--T-AAGGC AGAAATC---------------AAAAAATTTTTT---GAAAC------------------ ------AAATGAAAATAG-AGA------------CACAAC--ATACCAAAACCTC-TGG- GA-----TACAGCAAAAGCAGTG-----------------------------TTAAGAGG AAAG--TTTATAGCACTA----AATGC----CTACATCAAAAAGA---TAGAAAGATCT- --CAAATTAAC-AACCTAA-CATCACACCTA---AAGGAAC--TAGAAAAAC------AA GA--------AACTAAAC-------------CCAAAGC--TAGCAGAA-GAAAAGAAATA ACT---AAGATCAGA-------------------GCAGAACTA---AA-T-GAAATTGAG ACCAA------AA------------------------------------AAA-CAA---T ACAAAGGATC-A---------ATG----AAATAA-AAAGTTG------GTTCTTTGAAAG GATAAA------------------------------------------------------ --------------------------------CAA-----GATTGATAGACTA---CTAG CTA------GATTAA--CCA------------AGAAA------------------AAAAG A---GAGA-AGATTC-----------------AAATAAG--------CACAA-----TC- ---------AGA-AATGACA--AA----------GGTGA---CATTACAACTGATCCC-A CA-GAAATA--CAAAAGAT-CCTCAG---------AGACTACT--ATGAA---------- -----------CAT---CTCTATGCACACAA---ACTAGAAAATCTAG---AGGAAAT-- GGATAAATTCCT----------GGAAACA---------CAC-----AACCTCCCA----- -AGATTGAACCA---GGAAGAAATTGAAATCCTGAAC----------------------- AGACC------------AA-TAACGAGTTATGAAATTGAAT-C---------AGTAAT-- -AAAAAACCTACC------AACCAAAAAAAG---CCCTGGACC--AGATGG--------- ------------ATTCACA-GCCA--AA-------------------TTCTA-------- ----CCAGATGTAC---AAAGAA-GAGCTGG--TA-CCAATC----------CTACTGAA ACTATT----CC---AAAAAATTGAG------GAGGAG-GG-----------ATTCCTCC CTAACTCATTCT-----ATGAAACC-----AGTAT---CATCCTG-ATAC---------- ----------------------------------------C--AAAAT-------CTGGC AAA---------------------GAC---ACAACAAAAAA---AGAAAACTAC------ -------------A-GGCCAATAT---CCC----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACCA------------------AA--TC--------------CA--GCA----- --------GCACATC---------AAAAAGATAATTCA--CCATGAT------------C AAG---TGGGC-TT----------TATTCCT------------GG--GATGCAAGGATGG -T----------------------TC-AAC-----ATATGC--AAATCAATAAA--TGTG ---ATTCACCACAT------AAACAG----AATTAAAAACAAAAAC---CATATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTTGATAA---AATCCAACATCCCTT- ---------------CATGA---------T---A--AA-----AACCCTCAAC---AAAC TAGGCATCAAAGGAACAT-----ACCTCAAAATAATAAG--------------------- ------AGCCATCTAT-GACAAA--------CCCACAGC-----------CAACAT--CA TACTGAATGGGCA-----AAA-GTTGGAAGC----ATTC---CCC----CT--AAGAACT GGAACA----AGACAAGG-ATGT--CCACTC----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAAGGCATCCAAATAGGA---AAAGAG------GAAGTCAAA--T--------- ------TATCTCTC-TT--C---ACTGA------TGATAT------GATTCTATACCTA- -GAAAACC--CTAAAGA---TTCCGCCA---------A---------------AA--GAC TCCTAGACCT---------GA--TAAACGACTTCAGTAAAG--TTT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCATTTC--TA-TACACCAAT---------------AACATTCAAG-----CTG A------------------GAACCAAATC-AAG----AACTCAATCCCATTTACAATAGC CACA------------------AAAAAAATA---------AAA------TACCTAGGAAT ACATCT--------AA--C-CAAGGAGGTG---A---AAGATCTCT---ACAA-GGAGAA CTACAAAACAC------TGCTG-AAAGAAATCA-TA------------GATG-------- ------------ACAC--AAAC--AAA---TGGA---AA--AACAT---------TCCA- --TGCTC------ATG-GATTGGAAGAATC-A---A---TATC--------------A-- TTAAAATG-----------------------------------------ACCAT--ACTG CCC-AA--AGCAATCTACA-------------------GA---TTCAATGCA---ATT-- ------C-CTATCAAATT--A---------------------CCAATG-TC---ATTTTT ------------------------------------------CACAGAATTAG------- ---------------------AAAAAAACAAT------TCTAAAA---TTCATATGAAAC --------AAAAAAAAGCCC---AA--ATAGCCAAAGCAATCCTAAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACA---TTACCTGACTTCAAACT-----A TACTAC-------------------------AA---GGCTATAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------C---AAAAATAGACA--- ---CATAGAC--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAG-- -CCAC----------------ACA-------CCTACAA----CCAACT--GATCTTC--- GACAAA--GTCAACAAAAATAAAC--A-------------------ATGGG--GA---AA GG------------ACACCCTATT--CAATAAATGG---------------TGCTG---- ------G-GAAAAC--TGG-CTAGCCA---------------TATGC-AGAAGA---ATG ---------AAACTGGACCCC---TACCT-----------CTCACC--ATA--T---ACA AAAA-TTAACT-CAAGATGG---AT---TAAAGAC---TTAAATGTA--AGACCTCAAAC TAT------------------------AAAAATCCTAGAA---------------GAAAA ---CCTA------G------------------G-AAATACTCTTCTGGACATTG--GCC- -----TAGGCAAAGAAT-----TTATGACTAA-GTCCTCA---AAAGCAAATGCAAC--- --AAAAACA---AA----AAT---TGACAAT-TGGGAC----------CTAATT-AA--- ACTAAAGA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAACTAT-------------CAACAGAGTAAACAG------------------- ------A-------------CAACCT------ACAGAA--T-GGGAG---AAAATATTT- --GCAAACTATGCAT--------CC-------AACAAAGGAC--------TA--ATATC- ---CAGAATCTATAAG-GA--ACTTAA---ACA------AA--TCAAC------------ ---AAG------AA------AA--AAAAA---AAA--AACCCCA-TTAA---AAAGTGGG C--AAA---------GGA--CATGA---AC---AGACACTT------------------- -----CTCAAAAGAA--------GACATAC---AA-GCAGCCAAC--AAACATATGAAAA AAT----------GCTCAACATCACTA-ATCATCA------------------------- -----GAGA-AATGCAAA-----------------TC-AAAACCACA-------AT---- ----GA---GATACCA---------TCTC----ACACCAGTCAGAATGGCTATTAT---T A--AAAAG-------TCAAAAA-----ATAACA-GATG--T------------------- ------TGGC-AAGGATGTG----------GAGAA------------------------- ------------AAGGGAACACTTAT-ACACTGTTGG--TGGG----------------- ----------AATGT--A-------------AATT---AGTTC----AGCCACTATGG-- ------AAAACAGTT--TGGAG--A-TTTCTC--AAAGAACTAAAA--ATAGAACTACC- -ATTT---GA--CCCAGCAATCCCA---------------------TTACTGGG-TATC- --------------TA-CCCAAAGGAA------------AATAAATCA----T------- --------------TCTACCAA--AAAGACACCTGC---------ACTCA----TATGTT TATC--ACAGCACTATTCACAA-TAGCAAAGACAT--G--GA--ATCA--ACCTAG---G TGCCCATCA---ATGGTGG-----ATTGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------CATAT----ACACCATGGAATAC-----T--ACACA GCCATAA----AA----------------------AAGAATGAAATCATGTCCTTT---- ------------------------------------------------------------ --------GCAGCAACATGGATGCAG-C---TGGAGGCCATTATCCTAAGTGA------- ------------------------------------------------ATTAACGCAGAA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAA---------------------------------CCAAATAC-CA-------- ---CAT---GTTCTCACTTAT----------AAGTGGGAGC---CT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AACAT-------TGGGTA----------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TG------- ------GACATAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------TGGGAAC------ ------------------------------------------------------------ ------------------------------------------------------------ -----AATAGAC-----------------------------------------------A CTG-------GGGACTCCAA----------------AAGGGGGGAGGGAGGGAGGGGG-- -------------------------------------------------GC--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AAGGGTTGAAAAACT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TCCTATTGGGTA--------------- --CTATGTTC-------------------------------------------------- ------------------------------------------------------------ -------------ACTATTTGGGTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ATGGGATCAATAGAAGCCCAAACCTCAGCATC------------- ------------------------------------------------------------ ------------------------------------------------------------ -ATGCAAT-ATACCCAT------------------------------------------- -------------------------GT-----------------AACAAA---------- -------------------CCTGCACATGTACCCCCT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAATCTAAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AT AAAAATGAAAATAAAAAAA----------------------------------------- ------ >L1PB4 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAGCAGCTTTATGGATGATTGGTAGCGAC AGACAGCTG---------------------------CCTCCTCCTCAAAG---------- ---------------------------------------AAGAAAAAAATTAGCAG---- -GTAAATAATC------ACA---TTTTGAATAAACTTTTGAGA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------GAAG---------------------------AGTGCGGGAG-------CCAACA AGAGAGCTCCCAGGAAAAACTGGGGGTAGGAAAG---------A-AGAAGAAGGGGAGCC TGTTGGAGAGCAGC----------GACCGGG----------------------------- ----------------------------------------------------------AA TTGAGGAACCTGGTTTTCTATGGAAAAGGGTGGG-----GG---GGGGTTTCTTGGTTCC CCACGTCCCTGTG---------------------------------------GCAGACTG CTGGTTTCCGAGCTATTGGAGAGCTCCTCTGCCCTCACAGGCCTAAAGACTGGTGTGGGT AGCGAT-----------------------------------------TGGGAGCTTGTTT GAGGGCACTGCTTGTACTTGCAGGCTGTCCAAGGCTATCTCGCCCTCCCCCCATACCCAG ACTGGAGTGGCAGGCACAATACTGAGGTTGCATCCATTGGGGGCCTAAGTCCTGCCCGGG AAATCTAAGCCCTGATG---------------------------------TTTCAAAATA CCCGATTCCTCGTAAACATTCCCCAGCATCTACTCAGACTGCGG----CAGCCACA--AA GGGCTGGCAGGATCCAAGGGAGCTGCAGGATTCCTGGTGGTCTAACCCTCAAGGCATGCT GCTCTTGGGGAAAGGGAGTAAACATTGACAGAATTGAAGGGATAAATACATATCAACACA GTAAT------------------AGTAGGAGATTTCAATAGCCCACTTTCAATAATGGAT AGGACCACCAGATATAAGATAAGATCAATAAA-------------GAAATAAAGGACTTC TCTTTTTTTTCCCCCAAGGCGGCAGATCAGAGAC----------------------TCTT TTAGCATGCTTCACC------------TATTCAGAA---TCAAAAAAAAAAAAAAACAGA AA-------------------CAGAAACAAAATAGTAAAAA------------------- ------------------------------------------------------------ ----ATTACACAGGGTTCTGCAGCCTGCCATGAGGCGGGTACTGCCAGATGTCAGAACAG GGAGGGTGAGAAGGGGCAAGGTATTTACGCAAACCGACGACAACTGCCGCTGTCTTCTCC GCCATGGGCTGCGGGAAGAAGGTGCACTCTGACGATGTCCTGCGTGCCTGCGAACCTC-- ---------TACCACAGGTGCCTAGTGGCACGTTCCAAGCGAATGCGCCTAGCGTTGCTG GTGGGAGAAAAACAGAGCGGACGTTCTTGCGTTCAGGGGGTTTCCTCCGTTGGTCCTGTG GTGGGTTTGCCCCCCTCCTGCATGGCTATGGTTTTCGCGCGGGGGTCTTGAGGGGAGGTT CGCGGTTCTGGTTCCGCGCCGCGGTGGCTCTGGCGCCCCGCCCTGGGATGGGAGTGGGGG ATTTCT--------------CCTCCGCCCG-------CCGGGGGGGGGGGCGCCCCCATT GGCCGTGCTGGGAGGAGGGTGGGGGGTGGGCTTGCTGGGTGGATTGGGAGGCTGGGCCCC CCCCCCTTCTGTGGGCCGGACTGGTCGGGGCTTGG------------------------- -CCTGGGGTCCCGGTTTCTCCCCCTGGGAGCGCGGGGCCTCAGCG----GGGCCGGGATG GGGAG-TTGGGGAGCTGCGGTTCTCCCTTTGTCCT----------GCTGTGGGAAGTATG GGTGGCCGGGGGCCGTCGGCGCTGCTCCCCCGGGGGGCGCGGGCTGCATAGCCGTCGGTC ACTCCACCCTTTGTTGGTGGGCGTGTGTCCCTCTCTCACCGGGGGGCGGGTTCTGGCGCC GGAG------GGATGTGGTCCCTACCTGCCTAGTCGTTTTGCTTCCCCGGGCTGGGGGGT TCTTGCGTTCTCCTTGGGCTTTGTGTTGGTCTGTGCGCACCGCAAGGCTGGAGCCAGCTC CCCCCCCCACAGGGGTGGTGGTTGCTCCGGTCGTGACGGGCTGCGGGCTGGGCGCGTGGC CCGGT-----------------CCGCCCCCCT-------CTCCCTTTTCCCCCCCTCCGG GGCTGAGTAGGGAG--------------------------------CTCAGGCCACTGGG CA---------------------------------------------------------- ----TTCC---------------ATAGCCCAGCCCAT-----------------TGCCTG AGGCAACAGAGAGCTTCTCCTGGTAAACAAAGATCAAGCA-------------------- ----TATACCCATCTGCTTCCGCCGCAGCTGGCTC----TTACCTGCAAGCACCACCTAC TGGCCTGGAGGTTGAACTGCACAACC---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------CAATAAAAA TCCTGCTGACACAAGTGCACAGCGCTGGGGAA-----------TGAGATAAGCTTCCTGA GACCTCCACCCCCCCATCCCTGCAACCGCAGCCCCACAGGAGGCAGTGAGCCTGCTCACA TGCCCAGTACATCGCTACTACAACCAGCATTTGAGAAAGCCACCACA------------- --C-----------TAAGGCTATCTATTAACCAAGGAATTCATACAGAGCCTTGGCCACT --------TGAAAGCACCCAGAACCAAAGCCAAATGACCCTACACAACATACATTACA-- --------------------------------GTCAC--ATCCTCAAGGGG--------- ---------AAAAAAATCCCATCCAAATGAAAGTAAATTC-------------------- -AAAAATAA-------------------GAAGTGATAGCTTCTCCAGATGATAAGA---- ------------------------------------------------------------ -------------------------------TGAGAAGGAA-----CCAGTGTAAGAATT CTG-------------------------------------GAAATATGA--------AAA AACA----GGGTGTTA-------------TAAC--ACCT--CCAA---A-GG-------- -------ATC----ACACTAATTC-------------------TC-CAG---CAATAGAT CCTAATC----------------AAA---AAGAAATGCTCAAAATGCCAGTTAA------ ------AGAA------------TTCAAAATACTAAT-TATAAGGAAGCTCAATGAGAT-- --TCAAGAGAAAGTT--------------------------GAAAACCAACAC-----AA AGAAATC----------------------------------------------------- --AGAAAAA--------------------------------------------------- -CAATTCA----------AGATATAAATAAGAAATTCACT-------------------- -------------------------------------------AAAGAGATAAAAATTAA ----------AAAA---------------AAAACAG------AAC---------TTCTG- GAAA----TGAAA---------AATTC---ACTGAAGGAATTACAAAATACAGTTGAA-- ---AGCTTTAACAATAGA----------------CTAG--------------------AC C--AAGC------------------AGAAGAAAG-AAT-TTCAG--AGCTTGAAGAC--- -AGGTCTTTTGAAT-T-----AACCCAGTCAG---------------ACAAA---AAAAA AAAA---ATATTAAAA-AA---------TAA---AAAAAGCCTTT--AAGAAATATGGG- ATTAT--------G---TAAAGCG--ACCAAACCTATGA--G-TTATAGG--CATT---- ----------CCTGAGG---GAGAAGAAAAAGTA---AAAAGTTTGG---------AAAA CCTATTT---GA-----GGGAATAATTCAG--GAAAACTTCCCTGGTCT----------- ---------TGCTAGAGATTT--AGAC--ATCCAGATAC-----AAGAAGCTCAGAGA-A CACCTGGAA------------GATACTT-TGC--------------AAGAAGAACCTCAC C-------A---------------------AGGCATATAGTCATCAGACT------ATC- CAAAGTCAATG---TGAAGG--AAAAAATCC----------------------------- -------------TAAAAGC--AGCAAGAGA---GAAGCATCTAAT-------------- -----------CAC---CTATAAAGG-AAATCCCA--------------TCAGACT--AA CAGCAGACTTC-----TCAGCAGAA--ACCTTA-CAAAC------CAG-AAAAGAATG-- -----------GGG-GGCTATT-T-------TTAACT--TTCT-------------TAAA AAAAA---------------AAAATG--CCA--GCCAAGAA--------TTT---TATAT CCT-----------GCTAAACTAAGC-----TTCAT-AAATGA-------AG-------- ------------------------G-AGAAATAAAGTCTTTCCCAGACAAGC-AAATGCT AAGGGA-ATTTATCACCACTAGAC---CAGTCCTAC-AAGAA------------------ --------------------ATGCTCAAAGG----------------------------- -----------------------------------AGTTC--------------TAAACA TGG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------TGACA-------GGAACAAAA--------------------- ------------------------------------------------------------ --------------------CCTCATATA--TCAATATTAAC-CTTGAAT-------G-T AAAT--GGATT--AAATGC---TCCACTT----------------AAAAGAT------AT AGAT--TGGCAG----AATG---------GAT-------TAAA---AAA------CCAA- ---CCA-------TAT-GCTGCTTA-CAAGAAACCCACCT-AACTG--GTAAAGACACTT A-CAGACTCAAAGTAAAGGGG---T------------GGAAA----A-AAATATTCCATG C--------------AAAAAG------GAAAC---------------------AAAAAAT GAGC-G--GAGT----AGCTATACTTATATC-AGATAAAACAGACTTTAAA-TC------ ----AACAACAG---TAAAAAAA----AAAA-AAGGTCAT------TATAT------AAT GATAAA---GGGATCAATT------CAACAA---GAAG--------AT-ATAACAA-TCC TAA-----------------A----TATATATG---------CACCCAACACTAGAGCAC CCAG--ATT-CATAAAACAAATACTACTAGACCT--AA----AAAAAGA---------GA TAGACAGCAAT------ACAATAATAGTGGGGGACTTCAACA----------------CC CCACT------GACAGC-ACTAGACAGATCAT---------------------TGAGAC- -----AGAA----------------AAACAAAGAAACACTGGACTTAAAT-TGGACTCTA GA------CCAAATGG---ACCTAACAGACATTTACA--GA----ACATTCTACCCAACA AC---TGCAGAATATACAT------TCTTCTCATCTG-----CA--CAT-GGAACATTCT --C----CAAAATAGACCATATGTTAGGCCACAAAGCAAG-------------------- -TCTCAATAAATTTTTAAAAA--TCAAAAT----------------CATATCAA------ -GTATCTTCTCA---GACCACAGTGGAA-TAAAACTAGAAATCAAT-------------- ----------------------------------------------ACCA--------AG --------------AGG-AACTCTCA---AAACTATACAA----ATACATGGAAA--T-T AAACAACATG-CTCCTGAA---TG-ATCTTTG--GGTCAATGATGA--AAT--T-AAGAC AGAAATT---------------AAAAAAATTTTT---GAAAT------------------ ------AAATGAAAATAG-AGA------------CACAAC--ATACCAAAACCTC-TGG- GA-----TACAGCAAAAGCAGTG-----------------------------CTAAGAGG GAAG--TTTATAGCATTA----AATGC----CTACATCAAAAAGA---TAGAAAGATCT- --CAAATTAAC-AACCTAA-TGTTACACCTC---AAGGAAC--TAGAAAAAC------AA GA-----ACAAACCAAAC-------------CCAAAGC--TAGCAGAA-GAAAAGAAATA ACA---AAGATCAGA-------------------GCAGAACTA---AA-T-GAAATTGAG ACCAA------AA------------------------------------AAA-AAA---T ACAAAGGATC-A---------ATG----AAATAA-AAAGTTG------GTTCTTTGAAAA GATAAA------------------------------------------------------ --------------------------------CAA-----AATTGATAGACTA---CTAG CTA------GATTAA--CCA------------AGAAA------------------AGA-- ----GAGA-AGATTC-----------------AAATAAG--------CACAA-----TC- ---------AGA-AATGAAA--AA----------GGTGA---CATTACAACTGATACC-A CA-GAAATA--CAAAAGAT-CATCAG---------AGACTACT--ATGAA---------- -----------CAT---CTCTATGCTCACAA---ACTAGAAAACCTAG---AGGAAAT-- GGATAAATTCCT----------GGAAACA---------TAC-----AACCTCCCA----- -AGATTGAACCA---GGAAGAAATAGAAATCCTGAAC----------------------- AGACC------------AA-TAATGAGTAGTGAAATTGAAT-C---------AGTAAT-- -AAAAAATCTCCC------AACAAAAAAAAG---CCCAGGACC--AGATGG--------- ------------ATTCACA-GCCA--AA-------------------TTCTA-------- ----CCAGACATAC---AAAGAA-GAACTGG--TA-CCAATC----------CTACTGAA ACTATT----CC---AAAAAATTGAG------GAGGAG-GG-----------AATCCTCC CTAACTCATTCT-----ATGAAGCC-----AGTAT---CACCCTG-ATAC---------- ----------------------------------------C--AAAGC-------CAGGC AAG---------------------GAC---ACAACAAAAAA---AGAAAACTAC------ -------------A-GACCAATAT---CCC----TGATGAACATAGAT------------ ------------GCAAAAATCC-TCA--------------------A----CAAAATACT AGC-AAACCA------------------AA--TC--------------CA--ACA----- --------GCACATC---------AAAAAGATAATACA--CCATGAT------------C AAG---TGGGT-TT----------TATTCCA------------GG--GATGCAAGGATGG -T----------------------TC-AAC-----ATATAC--AAATCAATAAA--TGTG ---ATTCACCACAT------AAACAG----AATTAAAAACAAAAAC---CATATGA---- -TCATCTCAATA---GATGC---AGAAAAAGCATTTGATAA---AATTCAGCATCCCTT- ---------------CATGA---------T---A--AA-----AACCCTCAAC---AAAC TAGGCATAGAAGGAACAT-----ACCTCAAAATAATAAA--------------------- ------AGCCATATAT-GACAAA--------CCCACAGC-----------CAACAT--CA TACTGAATGGGGA-----AAA-GTTGAAAGC----ATTC---CCC----CT--AAGAACT GGAACA----AGACAAGG-ATGC--CCACTT----------------------------- ------------------------------------------------------------ ----------------------------------TCACCACTCCTATTC---AACATAGT ACT---GGAAGTCCTAGCCAGAGCAAT--------CAG-GC------AAGAG---AAAGA --AATAAAAGGCATCCAAATTGGA---AAAGAG------GAAGTCAAA--T--------- ------TATCTCTG-TT--C---ACTGA------TGATAT------GATCTTATACCTA- -GAAAACC--CTAAAGA---CTCCTCCA---------A---------------AA--GAC TCCTAGATTT---------GA--TAAATGACTTCAGTAAAG--TTT-----CAGGATAC- --AA-------------------------------AATCAA-------------TGT--- ACAAAAAT----CAGT-------------------------------------------- -----AGCATTTC--TA-TACACCAAT---------------AATGATCAAG-----CTG A------------------GAACCAAATC-AAG----AACTCAATCCCATTTACAATAGC TACA------------------AAAAAAATA---------AAA------------GGAAT ACATTT--------AA--C-CAAGGAGGTG---A---AAGATCTCT---ACAA-GGAGAA CTACAAAACAC------TGATG-AAAGAAATCA-TA------------GATG-------- ------------ACAC--AAAC--AAA---TGGA---AA--AACAT---------CCCA- --TGCTC------ATG-GATTGGAAGAATC-A---A---TATT--------------G-- TTAAAATG-----------------------------------------ACCAT--ACTG CCC-AA--AGCAATCTACA-------------------GA---TTCAATGCA---ATT-- ------C-CTATCAAATT--A---------------------CCAATA-TC---ATTTTT ------------------------------------------CACAGAATTAG------- ----------------------AAAAAAAAAT------CCTAAAA---TTTATATGGAAC C-------AAAAAAGAGCCC---AA--ATAGCCAAAGCAATCCTAAGCA---AAAA--GA ACA---AAGC--T-------GGA--GGCATCACA---TTACCTGACTTCAAATT-----A TACTAC-------------------------AA---GGCTATAGT-AACCAA---AAC-A GCA--------------TGGTACTGG--TA------------T---AAAAATAGACA--- ---CATAGAT--CA---ATGG-AACAGAATAGAGAACCC------AG---AAATAAAG-- -CCAC----------------ATA-------CCTACAA----CCAACT--GATCTTT--- GACAAA--GTTAACAAAAACATAC--A-------------------ATGGG--GA---AA GG------------ACACCCTATT--CAATAAATGG---------------TGCTG---- ------G-GAAAAT--TGG-ATAGCCA---------------TATGC-AGAAGA---ATG ---------AAACTGGACCCC---TATCT-----------CTCACC--ATA--T---ACA AAAA-TTAACT-CAAGATGG---AT---TAAAGAC---TTAAATGTA--AGACCTGAAAC TAT------------------------AAAAATCCTAGAA---------------GAAAA ---CCTA------G------------------G-AAAAACTCTTCTGGACATTG--GCC- -----TAGGCAAAGAAT-----TTATGACTAA-GACCTCA---AAAGCAAATGCAAC--- --AAAAACA---AA----AAT---AGACAAA-TGGGAC----------TTAATT-AA--- ACTAAAAA-----G------------CTT-CTGCA-------CA--------------GC -AAAAGAAAT----------------CAACAAAGTGAACAG------------------- ------A-------------CAACCT------ACAGAA--T-GGGAG---AAAATATTT- --GCAAACTATGCAT--------CT-------AACAAAGGAC--------TA--ATATC- ---CAGAATCTACAAG-GA--ACTCAA---ACA------AC--TCAAC------------ ---AAG------AA------AA--AAAAA--------AACCCCA-TTAA---AAAGTGGG C--AAA---------GGA--CATGA---AC---AGACATTT------------------- -----TTCAAAAGAA--------GACATAC---AA-ATGGCCAAC--AAACATATGAAAA AAT----------GCTCAACATCACTA-ATCATCA------------------------- -----GAGA-AATGCAAA-----------------TT-AAAACCACA-------AT---- ----GA---GATACCA---------TCTT----ACACCAGTCAGAATGGCTATTAT---T A--AAAAG-------TCAAAAA-----ACAACA-AATG--T------------------- ------TGGC-AAGAAGGGG----------AGAAA------------------------- ------------AAGGAAATACTTAT-ACACTGTTGG--TGGG----------------- ----------AATGT--A-------------AATT---AGTAC----AACCTCTATGG-- ------AAAACAGTA--TGGAA--A-TTTCTC--AAAGAACTAAAA--ATAGAACTACC- -ATTT---GA--TCCAGCAATCCCA---------------------CTACTGGG-TATC- --------------TA-CCCAAAGGAA------------AAGAAATCA----T------- --------------TATATCAA--AAAGATACCTGC---------ACTCG----TATGTT TATC--ACAGCACTATTCACAA-TAGCAAAGATAT--G--GA--ATCA--ACCTAA---G TGTCCATCA---ATGGATG-----ATTGGATAAAG--AAAA----TG------------- -----TGGTA-------------------------------------------------- ------------------------TATAT----ATAC------ATAC-----T--ATGCA GTCATAA----AA----------------------AAGAATAAAATCATGTCTTTT---- ------------------------------------------------------------ --------GCAGCAACATGGATGGAA-C---TGGAGGCCATTATCCTAAGTGA------- ------------------------------------------------AATAACTCAGAA ACAG-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AAAATCAAATACCACATGTTCTCACTTATAAGTGGGGTCAAATAC-CG-------- ---CAT---GTTCTCACTTAT----------AAGTGGGAGCT------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AAATA-------ATGTGTA---------------CAC--------A-- ------------------------------------------------------------ ---------------------------------------------------TA------- ------GACATAC----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGA--------GTGGAAT------ ------------------------------------------------------------ ------------------------------------------------------------ -----AATAGAC-----------------------------------------------A CTG-------GAGACTCCGA----------------AAGGTGGGAGGGTGGGAGGGGG-- -------------------------------------------------GT--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------GAGGGATGAGAAA--------------- ------------------------------------------------------------ -------------------------TT--------------------------------- ---------------------------------ACCTATTGGGTA--------------- --CAATGTAC-------------------------------------------------- ------------------------------------------------------------ -------------ACTATTCGGGTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ATGGGTACACTAAAAGCCCAGACTTCACCACT------------- ------------------------------------------------------------ ------------------------------------------------------------ -ATGCAAT-ATATCCAT------------------------------------------- -------------------------GT-----------------AACAAA---------- -------------------ACTGCACTTGTA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CCCCCTAAA-------------------------TC--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TATAAAAATAAAA-------------------------------------- ------