>L1ME3 -------------------------GGGGTGGTTCCAAGATG--GCCAAAT-AGGAAGAG CTCCAGTCTAC---AGCTCCTA--------GTGCGAGCGACG------------------ ---------------------CAGA----------AGACAAGTGATTTC--------TGC AT--TTCCAACTG-A-----AGTACCGGGTTCATCTCACTGGGG-----------CTTGT CGGA---CAGTGGGT--GCAGGACAGTGGGTGCAG--------------CCCACCGAGTG T---------------------GAGCCAAAGCAGGGCAAGGCATTG-------------- ------------CCTTACCCG-----------------GG--AAGT--GTAAGGGGTCA- -------------GGGA----ATTCCCTTT----CCTAG-----CCA-----AG-GGAAG CTGTGACAGACGGCAC------CTGGAA-ATCGGGTCACTCCCA-CCCTAATACTGTGCT T-------------------------TTCCAATGG-TCTTAGCAAACTGC----ACACTA GGAGAT-TATAACCCGTG---CCT------------------------------------ ---G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GCTCGGAGG----- -----GTCCCACGC-CCACGGAGC-------CTCG------------------------- -------------------CTCATT-GCTAGCA-------------------CAG----- ------------------------------------CAGTCTGAGAT------------- -------------------CAAACTGCAA-GGTGGCA----------------------- -GCCAGGCTCAAGGAAGGGGC-------------------GCCCACCATTGCTGAGG--- ------------------------------------------------------------ --CTTGAGTAGGTAAACAAAGCAGCTGGG--------------AAGCTCGAACTGG---- -------------------GTGGAGCCCACTGCAG----------------CTCAAGGA- -----------------------------------GGCC--------------------- -------TGCCTG---------------CCTCTGTAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ACTCCACCTCTGGGG-----------------------GCA GAAAATAGTTT-------------------------------AGGAAAAGATA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ TCTGAGATTTTTGCAGAC------------------------------------------ -TTAAATGT------CCCTGTC--TGACAGCCTTGAAGAGA------------------- -----------------GTAGTG--------------CT----------------TCTCC CAG----------------------CATGGAGTTTGGGATCTGAGAACGGAC-------- ------------AGACTGC--------CTCCTCAA---------------------GTGG GT-------CC---CTGACCCCC-----GA-----GTAGCCTA---------------AC TGGGAGGCAC--CCCCCA---------------GTAGGG------GCAGA---------- -------------------------------------CTGACACCTCAT----------- -----ATGGCCG----------------------------GG------------------ ------TACCCCTCTGAGATGAAACT---------------------------------- ----------------------------------------------TCCA---------- -----------GAGAAATTATTAAA------------------------------CATCC ACATCTGCTATTCAGCAATATTCG------------------CTGTTCTGCAGC--CTCC TCTGCTGAT----------ACC-------------------CAGGCAAACA--------- -------------CGGTCTGGAG------------------------TGGACC---TCCA GCAAA-------------CTCCA---------ACAG------------------------ ---------------------------------------------ACCTACAGCTGAG-- -----------GGTCCTCTATAGAT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CAAAGAA------------------------------TAT T-----------AATGAATTT--------------------------------------- ------------------------------------------------------------ --------------------------------------AAAGGA---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AAATGTAA--------------G-------------------------- ---CTAGATAC------AACC--------------------------------------- ---------------------------------ATACTGAAGCA---------------- ------CAACAAA--------GAGAAGATGTT-------GAAAATTCAAAAAATCAGAGG ATCTCTCCCCCTC-----CAA------------AGGAAAGCAGCTCCTCG---------- CCAG---CAGCCGTACAAA-------ATT-ACATGGAGAATAACTCAAATATATACAGAA GAAAACTTGACATAATGTAAGTGATCAAAATATTAAATGGAAATAATTGTTGTGTTACCA TCAGAAAATATAGAAACCTTAAGAAGGTAGAAGGTGATTAACTATTTATAATAATCAGTG CAGAGAAGTTCTAAAAGAATCGAATGTAGATAAAGACCATGGCACGAGAACTACGTGACA AAATTTCTATATTCAGTAAAAAATTTATTTAAAACGAAGAAAAAAAAAAGGAGTTTGAAA ATCATGTATATGAAATGAAGCGAGAAGAGAAGTTTAGAGTAAAAAAGGTGAAAAGAAACG GGTT------GAGAGAAG------AAGGC------------TTCAGATG---AT------ ----CAA---ACTTCTCCAAGCTA---AAAGGAAGAAG---------------------- ------------------------------TTCAAACCCACTGC---AAAGAAGC----- ----------------------------------------T------------------- ------AAAAATCTTGAATAAAAGA---TTAGATGAGTG--------------------- ----------------------GCTAA-------------CTAG------AATAATCAGT --------------------------------------GCAGAGAAGTCC---------- -----TGAAATGACC--------------------------------------------- ------------------------GGAT-GGAGC---TGAAA---------ACCAT---- -GGCACGAGAA----CTACGTGACAAATGCA-------CAAG------------------ --------------------------------------------CTTCAGTAGCCAATT- -----CAATC--AACT------------------GGAAG---------AAAG-GGT-ATC GGTGCTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGATCAGATGAATGAAA-T--GAAGAGA------GAAA---------AGAA--- ------------------CAAAAAAATAAAA---AGA---AAAAAAAGAAA--------- TAACACAAAGC----AA--CAAATATGGG-ACTATGTG-----------AAAAG--GCCA AATCTACGTC-TGATTGG--TGTACCTGAAA--------------GTGACGGGGAGAATG GAACCAACATGA---------AAAACAATCTGAA--A--------GATAATGACCA-G-G AAAAATTCCCCAACCT--------------------AGCAAGGCAGGCCA--ACATTCAA ATTC-----AGGAAATACAGAGAAT---GCCACA-AAGAT--------ACT--------- ---C-CTCGAGAA-----GAGCAACTCCAA----------------------------GA TACATAATTGTCAGATT------CAC-CAAAG---------TTGAAATGA---------- ------------AGG--AAAAAATGT---------------------------------- --------TAAGGGCAGCCAGAGA---GAAAGGTC--------------GGGTTAC---C CAC----------AAAG--------------GGAAGCCCAT--CAGACTAG-C--AGCAG ATC--------TCTCGGCAGG---ACTCTA-CAAA--CCAA-AAGAAAGTG--------- ----GAAGACAAATA-T-------TCAAAA--T-GCT-GAAAGAAAAA------------ -AAT-AT--CAA--AAACAGAA--------TTCCAT----------ATCCA--------- --GCCAAACTAAGT-----TTCA-TAGGTGA-------AGG-AGAAATAAAATCCTTTAC AGGCAAGC-AAATGCTGAGAGA-TTTTGTCACCACCAGGC---CTGCCCTAG-AAGAGCT CCT--------------AAAGGA----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------CAACCGATACCATC CACTGC------AAAAACATGCC------AAATTGATAACTGACAAAAC-----AGTACA ----GA------CCATCAAACCA----AGGA-------CAAAGCTGC-----ATCAACTA ATAAGGAGAATAACCAACAAATAGCAA--------------------------------- ------------------------------------------------TATGAAA----- --------------------GAATAAA--ATCC-AATCATAACAATATAGTGCAAATTCT ACTTTATCAGTAATTAC-ATTAAATG-TAAATGAATTAAAAATAC---TCCAATCAGAAG GCAAAGAG--CGACAGAG-TGATTATTTTTT-----------AAAAGATCCAACCA---- ---GAT-GTAATCTACAAAAA-ATCTATATTAGCATCAGCAAAAAAATCTTTCACTTTGA AA--TACAA-----TGGAAAA-ACATGTACCATACAAACAG------TAACC-------- -------------ACAGGGTAAG-AA--GTATTGCTGTACTAATAGC-AGACAAGATAGA TAATGAAACTTTAGATTTTTTAAGATCTTCCATAGATAATAAAA-AGGAACATTTTAT-- ----AATGATAAAA--AGGTTCAAAAAATT--AGGAAG--------AT-ATGACAATTAT AAATGGAGGACACCTGTAAATATATATGCTAACAATAACATAATTTCAAA--ACATAGAA AACAAAAATTGAAAGAAATGAAAGAAGAAATAGACAACTCCAGGATTAT---ATTTATAG TTGGAGATTTTAATATATATC-----CCTCAGAAACTGATAAA----------------- -----AAAAATGAC-----TAGAA-----AATCACTAATACTATAGAAGATTTA------ --AACATAAAGATTAACTGACTTGAA-TTAATTG--ACATATATAGAAGGCTCTATATCC AACAAGTA---CAGCATATAAATCCTCCTAATATGGAGGTAAGCCAT---GGAACGTTAC CACAGCATAAAATAGACCATGTATCAGGCAAGAAAGCAAGGGGCACATCATATTTTAATG ATTTAAATCAATCTAAAAGGA--TTAAATT----------------CATACAAA------ -GTATGTTATTT---GACCTCCGTAGAA-TTAAATTAAAAATCAAGAACAGAAAGATAAA A-------------GGAAATACTA---AAAAATCATCGC----ATGATTGCAAATTAACC AACAAA-TTCTTCAA---TA-ACTCATT--AGTTAAAGAAAATAAAAT--CAC-AAAGAG AATTAATAAATGCTTT---AAGAT------------------------GAATGATAAAA- -AAATAGAGC--ATGTGACAATTTATAAGGATTGCAACCAAGCCATGGCTTAGAGGAAAA --GTTATAGCTTGAAATGCATATACTGGAAAAGAAAATTT--AAAAGTCATATCAATAAA ------GGATCTTGGCCTTTAGCTA-----AGAAGAAGAAAA---AT---AACAGCAAAT TAAATCCACAGACTAACACCAAAATAGATGGAATCAAAGAAATAAT-AAAAATAAAAACA GAAATA---AAGGAAATTTAACATACAAATA-TAA---TAGAAAAAAATCAATACAGCAA -ACAGA--AATTTAGATTCTTTGAAAAGATTAA--------------------------- -----------------------------------------------------------T AA-----AA------TTAACAAATCA--TCTACCAT------GACTAATTCAACAAGAAA AATAAAGAAAAAACA---AGGAGAGA-AGATACAAATAGC-------------------- -----AAGAA---T---------GAGAATTAATAGA------GGTGT-----CCACTACA G--------ATCC-TTTAAACATT-TAAAAATAA--ATGAGT--------GTAGT----- -------------------ATTTTTAATAA-CTTTATCATAATAA--AT---TTGAAAAT TTTT---ATGACGT--TAGCAGATCCTTTGG---AAAAAA---------TAA-----ATA ACATAAAAATAGAAACCAGAAAAAAAAAAAATAGAAAATATGAACAATCTATGTCTTTAA ATAAATTGAATCCA------A------TAATTAATAACGAAAT----TGAAC--TTTTCA -TATTAAAACTTCCCACAAAGAAAAC--TT-CAGGCTC--AAATGTTTTCAAAGGTGAA- TTC--------------TCAAAAATTT----GTGAGAGAGATAATA-TTAATCCATGCA- ----TGAACAAAATTTTGCAG-------AGAATAG-AAAACAAAGG-----------AAC ATTTCCAAACACATTTTACAAG---------ACCAGCAG---AAGCTTGATATC--AAAA C-----------------------CATAC--AAGGACA-TTTC----AC---------TG AAGGAAAATT---------------------ACT------GGGCAATAT--CTC----TC ATGAATATGTATATGTTTATATATATATACACACACGCAAGAATAC-TAAA--------- ------TAAAATACTAGC-AAATGG------------------AA--T------------ ---C-CA--GTT-------------ACATATA---------AAATGAATTATAAA--AAG ----TGAT------------CAAGTGAGA-TTTATCCTAGGAA-AAAAAAAGGAATGTAT TTCATCAAATACAGTTTATTT-AAA-----ATATATTAAAAAACAAATGAATGTA--ATT CACCGT---------ATTACATTTAACAG----AATAAATGACAAAAAT---AAAATGA- ----TTATTTC---CATA----------GATATAAA--AAAG---TAATTCATAA---AT TTAAAAAAACCTT------------------TCTTGATTAAAAAAAACAACAAT-TCTCA --ACAAATCAGGAATAGAAGGGAACT-----TTTTCAATCTGAT---------------- -----------AAAGAACATGTTATAAAAACTCCCACAGA-----------TAACAT--C ATACTTAATGATGAAGT-T-----TTGGAAGCTATTT---TCCTTATGAT----TGGGTA TAAAACGTGGATGA-------GCAAAGT-------------------------------- ------------------------------------------------------------ ----------------------ACCACCATTCCAATCCAA-CATT--ATAC----AGAAG CCCCT-------------AGAAATTAG-------CAT-------------AATAATAGGC ---------GAGAG-------AGAGGAAAACAAG-------------------------- ----ATGC------------AAGGTAAAACATTCT------------------------T C--------------AAACGGTCTACTATAAAC---------AACAAATGCGAACTTAAT GAGG--TT-------------------------CCTGGAAACGA--------------AG TCAGT--------------ACAAAAATAATACATTTTAATTTC--CA-TGTATCAG--CA AGACAGGGG----------------------GAACGAAATATAGA----AACAAAACACC ATTTACAGCAGCATTTAAA---AAACATCAAATACTTAGAAATGAGTGT--------AAT -GAAATATGCGCAAGATTCAT---ACGCTATA--AACTGCAAAATGTTCTTG-AGAGAAA TTAAAGG-----------AC------------------ACCC--AAAT--GAATGCAGGG A-AC------TGTATAACGTTCATG------GATTGGGATAA-------GATAACTGTA- ------------------------TAAATGTCTCTTTTCTCTCC-AA------------- ----ATTTATCTATAGA---TTCAATGAAATAGAAATTAAATTGAAGAACAAACCTCTG- GTTTGTTGTTGTTGTTTCTT---------------------------------------- --TGAGGAGATTA---ACA------TTCTTTTTCTAAAA-TTTATATGGAA-------AT ACAAAGATCCAC---TA--ATGGCCAAGGCTATGTTT------AAGTTCA---AAGC--T -------AGAGGTCACATG---CTACCAGATAATAAGGC-----TTTCTGTAATCGAGAT TCAG--AATTTAAGG-AG----TATTTGGTATTGA------------------------- --CAAATA---------AGAT--CAATGGGATAGACTTGAGGGTCC------AG--AAAG AAA---TCCACTCACGTAAG----TTAATCTAGGATTTTTTAAGACAAAAGCATGATTGC AATTC------AGTTG-----AGAACGT----ATGGT--------CTTCT--CAATTAAT CGTATTG----------A--ATGACACTAGGA-TATTAT---------------TATTT- AAA---------AAA--------------------------------------------- ----TTA-ACAAAAT-TTAATT-TGGGATGGATCATAGACTTAAAGGTAATAAAACTTAA ACTTTC------------------------CAAACTTCTAAAG----------------- --AAACAAAAAAAACTA------G---------GGGAATTAAGGTTTATAATTAAAG--- --ATA-----GA-----AAGAGGAATTTCATAAATAG-AACTGAG-AAA----GCATTTT GCATAAG----------G------ATGCTTGACTTAAG---------------------- ---------------------------------------------------------AAA AAAAAACACTT-TCACA---CATC---AAAATATCATAAAG-TAAG-TGAAAAG-TCAGT CCAC--AGAC--T-GGGAT--AAGATATTT---GTAATATATTTAT--------ATGATA ATGGACTCA-------TATCCATAAAATATA--TAGAA--CTATT-----TCAAA----- --------------------TTTCAATAATAA------AAAGAG------------A--- GAGAACTCAA-TTTAAA----------AATGGGCAAA-----------AGT--CTTCAAT ---AAAGGATTTACGAAGGAGAATATCAAAA--------------TACCCGTT--AACAT ATAACAAGTTG----TTAAACATAATTAT-TCATCAGACA-AGTAAGAAATTTAAAAATA ACAATGAGA---------------------TACCAATTAAT-CCTACCACAATAGCAA-- ----AAATTTGGA---AGACTG--------------ACAACAC-------C-----A--- ---------------AGAATGCAGAACG-------------------------------- -----ATGAGAACTCTCAT-GCGTTTCTGATGTGAGAC---------------------- ------------------------------GAGTACATGAAAGC--------GTTATGAA GAAACCTAAGATA-GTA------------CCTACAGAGCTAAAC--ATTAGCATAACC-- -TACAA--ACCAATAATTCTACTCTTGAG-TATACG------ATGCCCG--ACAA----- -------------------ATGATTTTGACCAT--GAAAATACAAGATGTACAACAT--- ---------ACAAG--AATGTTCATACCAGCTTTATT---TGTAATAAGCCCCAAATA-G GG--AAAA--AGTCAA--TATTCATCA---ATGGTAG-----AATGG-------TAAAT- TG---------------------------------------------------------- --------------------TGGTATAGTC----ATACAATGGAATAA-----GCACACA GTAATA----------------------AGTATTACAGTTTGATTTCAC----------- ------------------------------------------------------------ -CCATTTATATGAAT-----T---T----------------CAAAAATAT--------GC AA------------------------------------------------------AATT A----------------------------------------------------------- ----------ACATATGGTGAT-------------------------------------- ------------------------------------------------------------ --------------------------------------------------GGAAGT---- -----------------------------CAGAATAG-TG-GTT--------ACC----- ------TCAGG---TAT------------------------GGGTGGTGATTCCTTGGAA GAGGTTAGG--------------GTAAAT---------------T--------------- ------------------------------------TCCTG-------------GG---- ---------------------------------------------------GTAATG--- -GAAATGTTCTA---TATCT-----TGATCCAT----------GTGCTG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------ATTACAAAGACATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ATACGTA---------------------------------------------- --------TGTA------------------------------------CATAGAAATTCA CCAAGC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TATACCCTTA-- -------------------AGATT-TGTGTA----------------------CTTTA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CTACA-------------------------------TGTATT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------CT----TCACTTCAA------TA- -------AAATTTAT--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1ME3E --------------------------TTCTGTTTTCAAGATACAGCAGGCA-AGAAATAC TTCAAAACCTT------TCTGATATAAAACGTTTAAAAGCTG------------------ ---------------------AATG----------AGGTGTAAGAGATCTGTTTACATGT ATTTTCAGGTTAGAAATGTGGGTACAGGTTCTGAGATGCTAAAA-----------TTGAC AAGA-------------------------------------------------------- ----------------------AAGCTCTAATACAAAGAGGTAGCT-------------- ------------------------------------------AGCCTTAAAGTTGGT--- -------------GGGCTTATTTTATAATTA---TCTGACTATTTCT--------GGATG T--------------------------------------------TCAGACTGTTTGGTT T-------------------------ATTTGGTTGCTTATAGGGAA--------GAAAAA ACAAATGTAATTCCCATG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------CAATCTAGGAT------------- ------------------------------------------------------------ -------------ATATGAGC-------------------AAAAAATTTTTTCAAAG--- ------------------------------------------------------------ AGTATATTTTATAAGGCAAAACCCTCAGTAAA-----------GGACTGAAATAGC---- -------------------ATATAGCCCATCATAG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------TCTTCACTATAGTTG------------------------CA GGGACC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------AGTAACCTCTGAGAA--------------------- --------------------------------------------------------ATCT TAA------------------------------------TCTCAAGACAG---------- ----------------------------TTCTCAT---------------------ATGA ----------------------------------------------------------AT AGGGGGGCA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------GGGGAGGGGGGTCAAA--------------------------------- -------------------------------------------------ATAGATACTTG CTTTGTGAC----------------------TACAAATGACCAAATGAAAA--------- ----------TTTTAGTTTAAAA------------------------TTCTCCTGGTTTG GTGGA------------------------------------------------------- -------------------------------------------ACCCCTAGGC------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ACC T-----------AACAAGTGGAAGT----------------------------------- ------------------------------------------------------------ --------------------------------------GCATGTTATCTCTGG------- ------------------------------------------------------------ -----------AAAAATGC---------------------ACTT---------------- ------------------------------------------------------------ --AGTAACCA-TGACTCAA----------------------------------------- ---ATAGTT--------------------------------------------------- ------------------------CTCATAGAAGAAATGTCAAA---------------- ------AACATAAA-------TCATGA------------TAAAATATGATAATGCAAAAT A-----------------CAT------------GAGGAAACAAGTTTTTA---------- TAAGACTCAGCAGAAGCAA--------------CAAGGAG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TAAAATTAGACC CACT-----------ATA-----------------------TCTGGAAAAATATG----- ----------AATCCCCTCAACT----ACAAGATAAGT---------------------- ---------------------------------AAGCTCAATATGTTTTAAAAAG----- ----------------------------------------T------------------- ---AAAGAAGAACATCAAAAGAATAAGGACAATAGATTA--------------------- ----------------------TATAA-----------------------AATAACAAAG ---------------------------------TAGATTTAAGAATAAGT---------- -----CAAATAGAAC--------------------------------------------- ------------------------TTCTAAGAAT---AGAAA---------AATAT---- -AACAATTTAA----ATTAGAAATACAATGA-------ATGG------------------ --------------------------------------------ATTAAGTATCAAATT- -----AGAAA--TAGC------------------TAAAG---------AGAG-AAT-TAG TGAACTG----------------------------------------------------- ------------------------------------------------------------ ----AAAAATAGATCTAAAGAAA-T--TATCCAG-------------------------- ------------------ATGCAATATAGAT---------AGGAAAGAGAA--------- TAA-ACAAAGGCAAATA--GAAATAGAAG-ATAGAGAA-----------CAGAG--GTTT AACATATT---TAACGGG--AATTCCAGAAA--------------GGAAAAAATAGAAAG AATGAAGGA------------AAAACAATATTTAAAG--------TAGATAATGGT-T-G AGAATTTCCAGAATT---------------------GATGAAAAACATCA--ATTCTCAG ATTC-----CGGAAGCCCAATAAAT---CCCAAACAGGATAAATAAAAATTTTTCTTACG CGACACTCTAAAAAAAAAAAGCGACACCTAAAAAAAAAATAAAAAATTTATCTAAGTGGA CACACTATAATCAAATA----------AAAGA---------CAGAAAGAA---------- ------------AAGATAGATAGTCA---------------------------------- --------TTAAAGCTGGTAAAAA---AAAGAGAA----------AAGAGAATTAC---A TAT----------AGAG---------------AACGATAAT--TAGATTTA-T--AGCTG ACT--------TCTCAATAGTAGTAATTTG-GAAG--CCAA-AAGACTATA--------- ----AAA-TAATATA-TAATAAGGTCAAAAACTATCTCCAGAGGATATATATAGTGAATT TACTATTTTTTATAGTTAATGA-----------AAT----------ATCCAGA------- --GCAATATCATCT-----TTCT-AATGTGA-------GAATGAAGACACATGTGTTTTC AGACAAAT-AAAAATTAAAGTG--TTTACCACCAATAGATCTCCAACTAAAG-AAAATTT TCC--------------CAAATG----------------------TGTAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------TTCAGAAAAATAAAAAATGATCTAGAAGGAAGGTCTGAGATGTAAGAA GGTATAAGGAAAACAAAGATAATTGG---------------------------------- -----------TAAATATGTGGTTAAATATAAACACACATTGATTTGATAAAACATTGAT TATGATAAATGTCTAATTTG---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TGAATTAAAAAAACCAAAAAAAAATAGAAGTAAAACATCAAAAAATAATGGTATATAT G----------------------------------------------------------- -----------------------------------------------TCATTTTAAGTAG AGGTAATGGAAATAAATCAGGTCAAATTGTTCTAAAGTTATCGTATTGTTTTGGAGAAGG GTAAAT----------------------------ATAGTGATTAACTTTTTATTTTATTA GATTAAGTTTGCATGTTGTAATTTCTAGGGAAGCCACTTCTTCTGCCCCCAGAAACA--- ----------------------------GATAGAAACAAAGGTAGTATCTTATTTCTATT TACTTG------AGGAAATTATT------A---------------GAAGGGAGAGAGAAA AATGGAGTCTGTATAAAAACAATTTAAAAAA-------AGAAAGAAAGAGTTAAAAAAGA AGAATTAAAACAAATGTAAAATGGA----------------------------------- ------------------------------------------------AAACACA----- ------------------------TAA--ATCC-AAATATATTAATAA------------ -------------TCACAATCAAATA-AAAATAAAAATCAAACTT-------GATAAAAG TGAAAGAT--TATCAGAC-TGGAT----------TTTAAAATTTAAAATCTAGATA---- ---TAT-TTTGTTTATAATAT-TTATACTT-AAAAT--ATAAGGATATAGAAAATTTGAA AA--TAAAAGAA--TGAAAAAGAAATATACTAGACAAATAG------TA----------- -------------ACAGA-AAAGCTT--ATATACTTATATAAATACC-ATCCAAAATAGA CTTTAATGTCTTTTTCCTTAAAAAATATTTATCAACTAT-AAAA-AGAGTCACTACATAG CTGAAATAATAAA---ATGTTCAATTAAGACCAGGGAT--------ATATAAAAAGTTCT AAAATC-------------GTATATTTGCATAAAATA-------ACCATAACATATTTAA CAGAAATGTTGATAAAAGTAAAGATGATTAAAGAAAAATCCAC---------TATCATGG TGAGAAGATGAAACATTTTAACAAA-TTTTAGAAATTAATAGA----------------- ----TCAAACAAAC------AAAACGTAGAGTGAGTAAAAATATAAAATATTTGAATAAT ATAATTAAATTTTTCAAAATGTAGATGTTAATAA--TTAAATATAAAAGCCACATTCTTT TAA--------TAGAAAATACAAC--------------AAAGCACATGT-AGAACATTTA T------AAAAACTGATGACGTATTAGGCTATAAAGCAAG-------------------- -TCTTAACAAATTTCAAAGAATCTTGATAA----------------CATATAGA------ -TCATATTATCT---AACTAAAG-ACAT-TTTAATTAAGTGTTTTTATTC--------AG A-------------GATAATACTTAAAAAAACTAGACAAAATCATGTGTGGAATTTAAAA AACACATCTATTAAA---TA-ACCCATG--GGTCA---AAAAAAAAAA--TCATAATACA AATAAAAATATCTTTA---GAACT------------------------AAATAATAATGA -AAATACTAA--ATATCAAAACTTG-TAAGCATGCAGCTAAATTAGTACTTGGAGGGAAA --TTTAAAGTCTTAAATGTGTACTTTAGAAAAGTTTTTAA--AAGGCTG---AAAATTAA ------TAATCTCAGCATACCATTTAA---GAAATTAAAAAA---AGTTTATTAATTGAA TAAACTCA-AGAAAAGTA------------GAAGAAAATAATATAT-AAAAATAAAAACA AATC-----AGTATAATGGAAAACAAAAATT------GTAAAGAGAATC-AATAAAGCCA -AAAGA-------TGGTTCTTTGTAAAGACTAATTGATTTTTAAAAAATTGCTTCTCAGC CTTTTGGCTAAGATCAAGTGATAAAAAATTATGATCAAGATTAAAATTATGATTAAGATC AA-----GA------CTGATAAAACT---GTGGCAA------TAAT-------------- AATTGAGGAGTAA---------GAGAAGGATAGAAATAAATAATATATATTAGGGAG--- -----AGAAA-------------TAAAAATAAAAAGTATTATGGAAAGTATATAACTACA A--------ATGG-GGCAGAGATT-TAAAAGAAA--ATAAG---------AAAAT----- -------------------ATTATGAACCAACTTTATGACAATAT--AA---TTTAAAAC TTAG---ATGAAATAAGCAAAAATTGCT--A---AAAAAA---------TAT-----AAA TTAAAA------AAATCAATTCAAGAAGAAATAGAAAACTAATAT--------------- --------GGTCTT------A------TAATCATTAAATAAAT----TGAAT--CAATAG TTTAAAAATCTTTCCCTTAAAGAAAA--CATGATGACC--AGAAAGTTTTACATAGTAAG TTCTG------------CCAAACATTG----AAAGAAAAGATAATT-TCAATCATACACA AAATTACACAAACTCTTTCAG-------AGAATAG-GAAAAGGGAT-----------AAT ATTTCATAATTC-TTTTTTGAG---------GCTAGTAC---ACCTTTCATGCT--AAAA C----------------------ACAGAAGGAGAGAAA---------AG---------AA AAGACAAATT---------------------ACA------GGCCAATTT--TAC----TT ATAAATATAGAT------------------------ACAAAAATTC-TTTA--------- ------GAAAATATTAAC-AAACTG------------------AA--TAGCTGAACACAC ATACGCAT-ACACACACACATTCATGTATATCCATGTATATAAAAAAATAACACATTTCA ----TTAA------------CAAATTTGA-TTTATCTCAGGAA-TGCAAG---------- -------------TTTGGTTT-AAC-----ATTAGA----AAATAGATTAATATA--ATT CACTAC---------A------TTAATAG----AAGAAAGGAAAAAACA---CATATGA- ----TTATTTC---AATG----------GATGCAGA-AAAGAAATCACTTGATAA---AA TTCAACATCCATT-------------------CATGATTTAAAAA-T-AAAAGGTTTTCA --GCAAATAAAAAATAAAATTTAAGT-----TTTTTTATCTGAT---------------- -----------AAAAAATAA-CTACAAAAAAGTCTGCAGC-----------AAATAT--C ATACTTAATGATGAAAA-A-----------------------------------AGGGAA GAAGA-AAGTATGT-------ATGCAGT-------------------------------- ------------------------------------------------------------ ------------------------TATTACTTTTTTC----TATACTATCCA---TGATG ACCTAGCCAT--------TGCAGTAAT------GCAATTT---AAAGA--CATTACATGT GTAAAAATTAGAAA---------AAAAGGGCAAA--AT------------TTT------- ----AGAATTGTA-------TTCATAGTAAAATT----------------AAAGAAAGAT ACAGAT---------AGATCAATTATTAGAATT---------AAGAAG--ATATATTAGC AAGT--TT-------------------------GCTAGATATGA--------------AA TCAACAT---------------AAAAT-----AATTGCTATTC--TA-TATGTCAG--CA ACAAACAGAAAAA------------------TAAAACAATTTTAA----AATATAA---C ATTTAG----------------AAATATCAAGTAACTAAAAATAAAACT--------ATC -ATAATATATGCAATAA-------TTAGGGAG--AAAACGGAAGCTTTATTG-AAAAAAA --------------------------------------ACCCTTAAAT--TAATGAAGAG ATAT------------ATTGTCATG------AGTCAGAGCACTT-----AACA-TTGTA- ------------------------AAA--------TATCTCTCC-AA------------- ----ATTGATCTATAGA---TTCAACCTGATTCCTGTGAAGT----------GCGAAGG- GT------------TTTCTTTTGTTATTGTTGCTGTTGCTGCTGTTTTCTTCCCCCAACC CCCGTGGAACTTG---ACAGACTACAATTAGTTCTAAAA-TGAATATATAA-------AT TCAAATTATCAA---AA--ATAATAAAAGCATTTTTAAAAAGAAAGGG------------ -------GGGGGACTAGCT---CTATAAAAGATTAACAT-----TTGCTATAA---AGCT ATAGA-AATGAAGAC-AA------TGTGATATTGG--CA-----------------CAGA GATAAACC------ATTTGAT---GTTGAAACAGGA-AGAGAACCC------TG--GAAT AGA---GAAACACACATATG----AACACT--AGACATGT---GATAGA--GGTAG--TA TTGCAGTTC--AGTGG-----GTAAAGG----GTGGA--------TGTTT--TGCTACTT ATTACTG----------A-TATATT--TAA-T-TATCCA---------------TATGG- TTA---------AAA--ATGAAGCTGGAGTCCT----TCCT---------------CATA CC----AAATAATGAACCAATT-CCAGGTGGTCTAAATGTAAAAATGAA--AGAC--AAC ATT-AT-------------------------AAACATTTGTAA----------------- ------GAAA--AAATA------G---------TAAACTATGTCTGTTCTCCCACAGAG- --ATATTCCCAGAGATTGAGAATGATTTCTTGAAATA-TATATAATAAAATAGATAAATT CCACAAAATTAAA-----------AT---TTAA--AAA-TGAGGTTTA------------ -------------------------------------------------------T---- TGAGGGAGATT--------------AAAGAAAATAATTGAGAAAAA-TAAAG---ACAAG CCAC--AGCA----GGG----AAGATGGCT---GCTGCACAAATAA--------TCAACA TGGCATGCT-------TACCCAGAACACATA--AAGAA--ATTCC-----ATGAT----- ----------------------TAAGTAAGAA------AAA------------------- GACAACTAAA-TAAAAA-------------------------------AAA--------- ---AGAAATTTCACAGAAAAGGAAACATAAG--------------TGGCCTAT-ACACAT GTGAAAG-----------------------TTATTACAAA-AAT---------------- ------------------------------------------------------------ -------TTCAAC-------------------------------------TCGGA-G--- ---------------CAGTTGAGGAGCA-------------------------------- -----GTGGACACTTTTGT-CCTCTGCTGCTTTGTG------------------------ -------------TGTA-------------AATTG-CTTCCACC--------ACTTTGA- -------AAAACAGGCATGGTA---------TAGTAAATTATAAAAAGTGCACAATCA-- --AAGA--TTCAGCAATTTCACTTCTAAGACATATACTCTGGAAAAAACTTTTAC----- -------------------AAATGTGT-ACCAAC-AGAGGTGTATAAAAAACATAGCAGT GATAGTACAACACT--GGAATTAATTGCAGCATATTCATGCATAGTA-------ATAT-- ------------------TGTCAAT-----GTAATAA----AAATGAATTAACTACAAC- TG---------------------------------------------------------- ----------------CATGTAACATAAAT----GTAATGTTTAGCACAAAATTCAAACA ACAAGATAAT------------------AAACATAATATAATTCCATTT----------- ------------------------------------------------------------ -----------GGGTAAAT-----T----------------TCAAAACAT---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ATAAAA---- -----------------------------TAAAACAA---TATG--------TTT----- -----------------------------------------TTGGGGGAAT---CTATAA A-------A--------------TTAGGT------------------------------- ------------------------------------------------------AAAATA CTTTTAGAA------------------------------------------AAAAAC--- -AAAATGATGATGATTTTTACTATAGGGTATGAC---------AAGGGA----------- TGGGGCCTAAGG------------------------------------------------ --GGG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CCCAAAG---------------------------------------------- -----------------------------------------------ATGGCTAAATCTG CTGGGT-----------------------------------------------------A GAG-----------------------------------------------------AA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CACCTGAGTG-- ----------------------TTTTGTCTT--------TTTGTCTCCTCTACCTAGG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CATATA-------------------------------AGTGTT------ ------------------------------------------------------------ ------------------------------------------------------------ --------------CATCT------------GGAAGTGTTTAATAATTAAT------AA- -------AAAACTAT--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1ME3B ----------------------------------------TGGGGTAGAG--AATAAAAG TTGGAGTCCAGA--CCCACTCA-------------------------------------- ---------------------AGGGTGTGGGTTGCTGCCTGGTAAAACC--------TCC ATGCCTGACACTGGG-----ATCCCCAAGGTTTGCATCCTAGAC---------------- -------ATAAGGGT--------------------------------------------- ----------------------AAACTGAAATTATAACAGTCCTTG-------------- ------------CAGACACTG--------------------TAGCCTAGCTTCAAGTCA- ----------------------------------TCTGAATGGTCCA--------GAAAA CTGTAAT--------------------------------------CCCTAAAACTGGATT A------------AAGTAATCCCAGATTGCTAGTG-CTTTAGGACCTGGCAGAAAAAAAA TGAAAATATTCTTTGGAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GAAAGTA ACGTCATCCTAGG--CCTCAAAATATTTTTACAAA------------------------- ---TAATTTTTCAAATACTATGTCTGACACA----------------------------- ------------------------------------CAATCAAAGGTAAC---------- -------------------CAGGCACAAAAGGAGACA----------------------- ----------------------------------------AGACAATGTAAATGAAA--- ------------------------------------------------------------ -----------ACTAGTAAAAACAACAGA--------------AA--------------- -------------------ACAGAAACCCTCAATG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ACTCCAGATATTGTG-----------------------GCT ATCAGACAGAC------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -TTAAAA-----------------TAACCATGCTGAAGGAGACAGGAAGACATAGTT--- ---------GAATTAGCGGACTG--------------GAAGTTAGGTCAGAAGAAAAATC CAG-------------------AATCAAGCAGGAAGAAACAAACAAAAAT---------- ------------GGAAAAA--------TTCATAAAAGAAGGTAAAAGAAGG-----CCGG GCACTGAGGCGGACAAGACGCCA-----------------------------------AT ATAAAGACAC--CCCATCTAATACGAATACCAGGAAGGA--------------------- -------------------------------------GAGAGATCCTATA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------GAAGAAATATTGAAGAGATA----------------------------- ------------------------------------------------------------ -------------------ATGGCAGAGCATTTTTAAAAACCAGTTAAAGA--------- ---------------------------------------------TATTAACCTACTGAT TTAAG---------------------------AAAG------------------------ ----------------------------------------------CCTACAACCCC--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TAAGAAA--------------------------------- ------------GATAAATA---------------------------------------- ------------------------------------------------------------ --------------------------------------AAAAGAAGTCTATACCT----- ------------------------------------------------------------ -----------AGACACAC----------------------------------------- ------------------------------------------------------------ --AACTGCTAAAAACTAAAGGCGGGAAGAGAAAATCTTAAAAGCAGTC------------ ---AGAAAAAAAAAATTACCT--------------------------------------- -----------------------------GCAAAAAATGGGGAG---------------- ------AAACCACA-------GCAGAAAGGCT-------GAAAATTCCAAAAACCAGAAC GCCTCTTCTCCTC-----CAA------------AGGAAAACAACTCCTCG---------- CCAG---CAAGGGAACAAA-------ATTAAGATGGAGAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-GTTTGATG AGTT------GACAGAAG------TAGGC------------TTCAGAAG---GTCAGT-A ATAACGA---ACTTCTCTGAGCT----AAAGGAGCATG---------------------- ------------------------------TTCTAACCCGTCGC---AAGGAAGT----- ----------------------------------------T------------------- -------AAATCCTTGAAAAACAGG---TTAGACGAACG--------------------- ----------------------GCTAA-------------CTAG------AATAGCCAGT --------------------------------------GTAGAGAAGAAC---------- -----TTAAATGACC--------------------------------------------- ------------------------TGAT-GGAGC---TGAAA---------ACCAC---- -AGTACGAGAA----TTTAGTGAAGCATACA-------CAAA------------------ --------------------------------------------CTTCAATAGCCAATT- -----CGATC--AACC------------------GGAAG---------AAAG-GAT-ATC AGTGATT----------------------------------------------------- ------------------------------------------------------------ ----GAAGATGAACTCAATGAAA-T--AAAACAA------GGAG---------ACAA--- ------------------GATTAGAGAAAAA---GGA---GTGAAAAGAAA--------- TGA-ACAAAGCCTCCAA--CATACATATA-ATTGGGTG-----------AACAG--GCCA AATCTACAGT-TGATTGG--TGTACCGGAAA--------------ATGACCGGGAGAATG GAACCAAGTTAG---------AAAACACTCTTCA--G--------GATATTATCCA-G-G AGAACCATCCCAGAAA--------------------AAGAGGAAAGGAAA--ACATAAAA ATAG-----AATCAACATACAGAAT---AGTGCAAAAAAT--------TTT--------- -----TTTGAATATAAGTAAAAGACACCAA----------------------------GC TACACATTTGGCAAGCA------TAT---------------TCGAGAA------------ ------------AGA--AAAAAATGT---------------------------------- --------TAAGGGTAGCCAGAGA---GAAAGGTC--------------AGGTTTCAAAC TA-----------ACAG--------------GCAGGTTCAA--GAAATTCA-C------- -----------ACTTAGAAATATGATAATA-AAAG-TACAGAAAACCAAAG--------- --------ACAAAGA-AAAAGTAGTCAAAC--T-AAC-CAGAAAAAAA------------ -GAG-TT--TCA--ATCCAGAA--------TAGTCT----------ACAAA--------- --GAGTAACTTACA-----TTCG-TAAGTCACTTCTATATG-AAAAATGGA--------- AGCCAAAGACAGTGGTATGACACATTCCTAGTGGTGAAAG---AAGCCTCAC-AGGAGCT CCT--------------GAAGGA----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ -----------CAAACATGGATAGGAACAACTGGTACCAGCCACTGCAAAAGCATGCCAA ATTGGGGCAGACAGAAAATGACCCCAGAAGAAAAGT------------------------ -----------TAGAGATGCAGGAAAAAATAAAAGGCAATGAAAAGTGAGTATAAATGAA TACTGACCGCATAAAACATAATAATGATGTGTTGGATTTAAAATTACAGAT--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------AATTAAAATACACAACAACAACA GCAACTAAATAATATCATAGCTAAAGCATATTAAAGTCCCTGAATTATCTGGGAAAAAAA TAAAAGTACCAATTA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ACAG-------------ACTTTGATA GATCAAAAATCTATGTTGTAATCTTTAGGTTAATTACT---------------------- ----------------------------AAAAGAATAGTAATACAGGAATATATATCTTC TAAACTAAAAGAAAAAAAAAATG----------------------GAAT-----AATAAA ----AA-GTAGTTTAACAAAGCAAAAAATGA-------CAAAAAAGG-----CAGGAAAA GTGAGAAAAAGGAACATATATCAGC----------------------------------- ------------------------------------------------TGGGACAAATAA AAAGCACATAGTAAAATAGTGGATTTTTTATCC-AAATATATCAGTAA------------ -------------TTAT-AATAAATG-CAAAGAGATT--AAATGC---TCCAGTTAATAA TCAAAGAT--TGTCAGAC-TGGAT------TTTTATTAAAA---------CAACTA---- ---TCT-GTTGTTTACAAAAG-ACATGCCT-AAAAC--ACAAGGATACAGAAAGTTTGAA AA--TAAAAGAA--TGGACCA-AGGTATTCCATGGAAACAG------TAAAC-------- -------------TAAAG-AAAGCTG--GTGAGGCTATATTAATAAA-GACTAAAATAAA CTTTAAG-GC--------AAAAAAAGTATTAGTAGAGTTAAAAACAGGGACACTTCGT-- ----AATGATAAA---TGTTTTAGTTTAATAAAAGATG--------AA-ATAATAATTCT AA-----------------ATTTCTGTGCATTTAAAAACATGGCCTCAAA--ATATATAC TTTAAAAAGTGACAAAAATAATAGGAGAACTGGATAAATCCAC---------AACCATAG TGGGCAATTTTAACACATCTT-----TCTCAGTAACTGATAGA----------------- ----ACAAGCACAC------AAAA-----AATTAGTAAGATTCAGCATGATCTG------ --GAC-AAACTTGACA--------AC-CTAATTG--ACATGTATAGAA--CCCGGCACTC AACAACTC---CAGAATGCACATTCTTTTCA-------AGTGCACAT---GAAGCATTTA C------CAAAATTGATTATATGCTGGGCAATAAATCAAG-------------------- -TCTCAATAAACTTCAAAGGA--CTGAAGT--------------AAAATATAGT------ -GTATGTTCTCT---GACCACAATGAAACTTAAGCTAGAAACCAATAATA--------AA A-------------AG-GTAACTA---GAAAATCCCTAA----ATGTTTGGAAATTAAGC AATACA-CTTCTAAA---TA-ACTTCCGTGGGTCA---AAGAAGAAAT--TAGCAATGGA AATAAGAAATTAATTT---TACCT------------------------GAATGATAATGT AAAATATGAC--GTATTGAAACGTG-T---GATGCAGCTAAAATCATGCGTAGGGAGAAA TGTGTATAGCATTAAATGTATATATTTGGAAAG---AAGA--AAGGCTG---AAAATCAA GCCAATCAATCCATCTTAATAAGTAG----GAAAATAGAAAA---AA---TAACGCAAAT TAAACCCA-AGGAATGCA------------GAAGGAAGAATATACA-AAAGTTAAGAGCA GAAATT---AATGAAATAGGAGCAATAATGT-----ATGAGAGAAAATC-AACCAAACAA -AAAAT-------TATTTCCTTAAAACAACGAA--------------------------- -----------------------------------------------------AAATGAT AA-----AA------TTAATAAACAT--CTTGGCAA------GACC-----------GAT CACAAAGAAGAAG-----GCAAGAGA-AGGCACAAATAAG-------------------- -----CAATA---TAGCAATAT-AAGGAATGAAAAA------GAGGA---CAAAGGAACA A--------ATAT-TACAGACATT-AAAAAGATA--ATAAA---------AGGAT----- -------------------ATAATGAACTA-GTTTATGCCAATAA--ACAATTTGACAAC TTGG---TTAAAAT--TGACAAATTCAT--AATTGACACA---------GAA-AAAAACA TTACCA------AAAGTGACACA-GAAGAAATAAAAAATCTGAAT--------------- --------AGTCCT------A------TAGCTATAAAAGAAATTAGATGCAT--CCATAA --AGAAAAACTTCCCATAAAGAAAAC--TT-CAGGCCC--AGATGGCTTCATCAGCAAAG TTCCA--------------AATTATTTTAAAAGAAAAAAACTAACA-CCACTC-----T- ----TACATAAATTCTTCATACTTCGGGAGAATAGAAAGAAGA--------------AAA ACTTTCCAATTCATTTCATGAT-----------AAAAAA---AAACTTGATACCAAAATA C-----------------------CCTAC--AAATTCT-TTAC----AA---------AA AAGAAAAATT---------------------ACA------GGTCAATCTTGCTC----TC ATAAACATAAAT------------------------GCAAAAATCC-TAGG--------- ------TAAAATATTAA--AAATTC------------------TA--T------------ ---C-CA--GCA-------------AAATATT---------AAAAAATTAAATC---CAG ----TGAT---------ATATAAAAAGGA-TTCATTCCAGGAA-TGCAATACAGGATTGA TTATATTAAATGCGATAACTC-AATTTTGCATTCAA----AAATCAATCAGTGTA--ATT CATGTC---------A------TTAACAA----AATACAGGAGAAAAAT---TGTACTA- ----TTATCTCCTTAATA----------GGCATAGA-AAAAT---AATCTGATAAAATAA TTCAACATCCGTTAAAATACTACTACTACTATAATAA---------TAATAAACTTCTTA --GAAAACTAAGATGGAAGAGAATAGAAGGATCTTTAATCAGAC---------------- -----------AAAAGGTGT-GTAC--ACAAACTTATATA-----------AAACATCAC ATACTTAATGGTGAAATAA-----TTGAATGT-TTTC---CTTCAGGAAC----TAAAAA TGAGACAAGTATGC-------CTACTAT-------------------------------- ------------------------------------------------------------ ------------------------TACCATTTCTATTCAA-CATT--GTACA---GAAGA TTCTAGGCAGCTAAAAAAAGCAATAAAAGAATTTTAAAAGAAAAATAA--GATAAAAGGT AAATGGATTGGAACTATCATTATTAAAACTGAAA--TTAT------------------TG AT--ATAAATATAAA-----TGTACAAAAAACACG---------------ATTGTATAC- ---------------AAATAAACTATTAGCATT---------AATAAA--TAAATTTAGC AATGATTT-------------------------GCAGGATATAAAACACTGGCTATCAGG TCAATATCATTTCCACATAGTAAAAAT----AAATTATATCTT--TC-TATTCCAG--GA CCAAAGAATTAGA------------------AAATTAATTTTA------AAAATTATGTC ATTTACAATAAC-ATCAAA-----AGATGAAATTCCTAGGAATAAAATT------CATAT -CAAATACGTAAA---TCTCT-----ACGGAG--AACTAGTAATACTAAATA-AAAGGAT TCGAAAAACCACCACAATGA------------------AAACCTCAAT--AATTGGAGGG ATATGGAAGACTGACTATGTTTATG------AAATAAATAACTCACATAAATTGTTATT- ------------------------TAAGGATTCAATT-CTATGC-AA------------- ----ATGCACCTATAAAAATTTCAATGTAGTCCCATTCAAAAT---------CCCAGCA- GC------------TGTTCT---------------------------------------- --GGTAGAACTTG---ACA------AGCTGATTCTAAAA-TTTATATGGAA-------TT GCAAAGGGCCAA---GA--ATAGCCAAGACAATCTTGAAGAAGAAGAAGA---AAGTAGT TTTGTTCGGAGAACTTACT---TGACTGGATATCAAGCT-----TTATTTTAA----GTT A-AGT-AATTACAAAAAGATGCTACGTTGTATTAGCTCAAGGATAAATCCCCCTCCCCAA AAAAAAAA------AAAAAAAGCAAATGGAATAGAACAGAG--CTT------AG--AAAC AGACTTACCACATATATATG----GACACT--TTATTTAT---ATCAAAGAGGTGACATT GCAGCAA----AATGA-----AAAAAGG----TTGTG--------TTTTT--CAATAAAT GGTGCTG----------G-GCCAAT--TAG-A-TATCCATT-------------TAAGGT AGAGATGGG---AAAAAAAAAAATTGAAACCCTAATCTCCTTCCCACTGGATTATATATA A---ACAGAGAAAAA-TCAGTT-CCAGGTGGATTGTAGATCTAAATGCGTAAAAAGTAAA AGC-AT----------------------------ATTCTGGAAA---------------- ------GAAATTACATA------T---------GAGAGTATCCCCATAACCTTGAAGTC- --AAT-----GG--GGAGAGAAAGAGCTCTTAAACAA-AACAAAACAAA----ACGTCTG AACCATAAAATAAAGGAATCCAATAT---TGAT--AAA-TTGGACTAC--AT-------- -------------------------------------------------------T-AAC ATTAGGATCTT-CTGTAAATCATC-AAAAGATACCCTAA---AGAGTTGGAAAG-ACAGT CTC---AGAG--T-GA-----AAATTATTT---GCAGAAGATACATATTCGGAACTAGCA AAGAACTCA-------TATTTATAATATATACCAGCAA--ATTAG-----AAAGATATCC TCATA-----------------TCAATAAGAAATTTTTAAAAAA------------A--- GACAAACGAA-TAAGAA-------TAAAGTGGAAACA-----------AGA--CCTGAAA ---TGGAACTTCACAAAAGAGGATATTCAA---------------TGACCTCTAAAACAT ATGAAGAGCTG----TTTAAGCCAATTTAGTAGTCAAGGATGAT--TTAAATTAAAAACC ACAATGAGA---------------------TACCACTATACACCT-------TGGCAT-- ----TCAACAAAA---ACTTTGACA-----------ATATCAA--GTG--TTGGT-G--- ---------------AGAACATGAAGAATACAAATTATACAAGGTGTAGTCAAGGGTGTG AAATCACTGGAACACTCAT-ACACCCCTGG--TGGGAA---------------------- -------------AATA-------------AATTG-ATACCATT--------ACTTTGG- -------AAA--A-GTTTGGAA--ATAA-CTATTAAAATTAAAT--ATACATATAATGCC CTTGAA--TCTAGAAATTCCATT-CTAAG-TATATA-CCTAACAGAAATGCATAA----- -------------------ATACGTAC-ACCAT--AAA---ACATG----------T--- ---------GAGAG--AATATTCATTGCAGCATTGTT---TGTAATA-GCCTCAAACT-G GA--AACA--ACCCAAA-TGTCCATCA---ACAGTAG-----AATAGATAAA--TAAAT- TA---------------------------------------------------------- --------------------TGGTATATTT--TCATGCAATGGAATAC--TATACT-ACA GTGAAA----------------------ATGAATAAACTGCAGCTACAT----------- ------------------------------------------------------------ -GCAACAACATGGATAAAATC---T----------------CACAAACATACAGTTGAGC AA-------------------------------------------------------AAG A----------------------------------------------------------- ----------AGCCA--GATAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------TAAAAA---- -----------------------------ATAAATAGATACCTT--------TACACAAA ATTAGTCCATT---TAT---------ATAAAATTCAAAAACAGGCAAAA-----CTAAAT T-------ATGGTGTTTAAGGAATGCACA---------------C--------------- ------------------------------------TTAGGTGATAAAACTAAAAAAATA ATTGTTTTA------------------------------------------GAAATT--- -AGAATAGTGTTTACCTTTA-----AGGA--------------GAAGGA----------- AGGTGCTGTAGG------------------------------------------------ --ACAATGCATGAGGGCT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------CTGGGTTGCTGGTAATGTTCTA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------TTTCTTG---------------------------------------------- -------------------------------------------------ATCTGGGT--G GTGGTT--------------------------------------ACACGGGT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ATTTACTTTTTA--------A-------------CTACT-- ------------------------------------------------------------ ------------------------------------------------------------ CATTAAACTGGACATTTAT----------------------------------------- ------ATTT-TATGCAGTTTTTTAATTG-------------------TGTACT------ ------------------------------------------------------------ ------------------------------------------------------------ --------TTTTTGCAATT------------AAAAGTT-------TTAAAA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MD1 -----------------------------------------------TAGA-AGAAGTAT TTTTTAT-------TATTCTTT--------TTAATAAAAACA------------------ ---------------------AAAA---------AAATCAATATAAAAT----------- ---------ATAAAA-----AAAACAAAAAAAAAATTATAAAAG-----------GAGAA AAAA---AAAC------------------------------------------------- ---------------------GGAAAACAATCAAGGAAATTAGAAA-------------- ------------TCAAAAAAT-----------------AA--CATGGTGATGAGTACCC- -------------TGGGTTTTCTTTTTGCC----TCATATATCCCAG-----AC-TTGGA GCTGAAGAAG-----------------------------------CTGGCAACTCAGAAA T------------------------ACCAACAGGTACATTTTAAGAAAGC----CCAACC AAAGTCCGCTCTCTTTAA---CCC------------------------------------ ---AAAGAAAAAGAAGCAGTCTAGCAAGACAG------------------AAAACTATCT GCTAAGAAACGCTCTACTCTG---------TCTTAGCTAAAGTACATAAAATAAAA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------TTATGACCTCAATATTACTCATTCCAGCA-------------- ---AAGGCTGAGTGGGGAGCCTAGACTTTTACCCTCGCAAG------------------- ------------------------------------------------------------ --------------------GCTGTAATGAGGCGCTCAAAAACCCCAAT----------- -TAGGTGGCCTGATAGGGTGT--------------------------------------- ------------------------------------------------------------ ---------------------CGTGTAGA--------------GAACTAGA--------- -------------------GCGGTGATCCCCACCA----------------ATCATAAAT GA-------------TGTCCACTAATAAC------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------TTCTCTTCCCATGTTGAGAGTAAAAACTATAATCCAATGGTA AACAAGTCACC------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TACACAATAG------------T ATCAATTGC------TGCAACC--TACCAGTTTGGGAG---------------------- ------------------------------------------------CCAAAACCCCAC CCT--------------------------------------------------------- --------------------------------------------------------GTGG GTAGAAATGAC---GCTCTCCCC-----CC-----ACTGCTGT---------------GT TGATGGGGGT--T----------------------------------------------- --------------------------------------------------------AAGC GGGGAACAGGGACTTCTTGTGCTACCTGGCCTTCATACATCA------------------ ------ATAGACATCATGATGACATCTCC------------------------------- ----------------------------------------------CCCCTCCCCCTGCT GGGGTGGTGTCAGAGAAAGCCAGCTAAAA--------------------------CAGAG GGTTTA-----------------A------------------ATAAGATCCAGAGTCTCA TAACGTAAT----------AAAAACACGTAGGTTTTTAATTTAAAAAATCATTCATCCTA CCAAGAACCAGGAAGATCTCAAG------------------------GAAAATGGATTGA AAAGA-------------CCA-----------TCAG------------------------ -------------------------------------------TTGCCGACAACATGAAA A---CGGCAGTGATGTAGTATAATT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TAAAGAG------------------------------GTT T-----------TAAAAGCAGCCATCATAAAAATACGTCAATGAGCAATT---------- ------------------------------------------------------------ -----ATGAACACACTTGAAGCAA------ATGGAAAAATAGAAAGCTCCAGCAAAGAAA TA---------------------------------------------------------- -----------GAAAATCT----------------------------------------- ------------------------------------------------------------ --CAGCAAAG-AAATAGAA----------------------------------------- ------------------------------------------------------------ ---------------------------------GATATAAAGAA---------------- ------GAACCAAATTGGAATCTTTGGAAATG-------AGAAATAAAATAAACTAAATT G--------------------------------AAAAGCTCAGTGGATGG--------GC TCAA---CAGCAGAATGGA-------GGG-GAAACAAGGA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AAG-AATCAGTG AACT------GGAAGATA------GAATA------------ATGGAAATTGCACCTAATC TTAACAATAGAAAGAAATTAGACTAAAAAAAAAAAAAA---------------------- ----------------------------GAACAGCACCGAGCCC---AAAGAATC----- ----------------------------------------T------------------- TACATTTATGTATTTAGAATACATG---CTTGAAATAGC--------------------- ----------------------TGAAATTACAGAAATGCTAAAATTATCTGGCAAAGATT --------------------------------------TTAAAGCAGCCC---------- -----TGACAAGAA---------------------------------------------- ------------------------TTTT-AGAAC---TGAAAAAACAGAATAATAC---- -AAATAACAAA----ATAAAAAGCTCAGCGC-------ATGA------------------ --------------------------------------------TCTAGACAGTAGAAG- -----GAAAA--GGAC------------------AATGC---------AGGG-AAC-TGA AGAACTA----------------------------------------------------- ------------------------------------------------------------ ----AAACAAAAAACAATAAAAA----TACACAATTTCAGTAAACTAGAAAATAGAATGA AGAAAATATACAATAGTCAGAGAAAGAAAAA---AAA---GAATAAAGAAA--------- --A-AGACAACTTTGGA--GTCATCTGTG-ACAATATA-----------AAAAAATATCT AATATTTCTT-ACAATGG--AGTACCAAAAA---------------GAAAGAAGAAAAAG AGGGGGGGTTA----------AAAAAGTACTCAA--A--------GAAATAATGGC-T-G AAAACTTCCCAAATTT--------------------GGCAAAAGACATAA--ACCTACAG ATTC-----AAGAAGCTGAGTGAAC---CCCAAA-TAGGA--------TAA--------- ---A-CCCAAAGA-----AATCCACACCAA----------------------------GA CACATCATAATCAAACT-------TC---------------TGAAAACTA---------- ------------AAG--ACAAAAATT---------------------------------- --------TAAAAACA---AGAAA---AAAAGAAA--------------ACACCAC---T TAC----------AGAG--------------GAAAAACAAT--TAAAATGA-C--AATAG ATT--------TCTCATCAGAA--ACCATG-GAGG--CCAG-AAGGAAGTG--------- ----CCA---AAATA-T-------TTTTCATGT-TCT-TAAAGAAAAA------------ -AAACTG--CAA--CCCAAGAA--------TCTTA-----------AACCA--------- --AGAAAATTATCT-----TTCA-GGAATAA-------GGG-AGAAATCAAGACATTCTC AGATGAAG-AAAAACTAAGAGA-ATTTGTCACCAGCAGAC---CTACCCTAA-AAAAAAG GAT--------------GAATAA----------------------AGTTA---------- ------------------------------------------------------------ ---------------------------------------------------TTTGTATAA ACAGAAAGGAAATGATTAAAGAAGGAACCTTGGGACATCGGAAAGAAAGACAACTGAAAA AAAATTATAAAAGAAGAAACCTTGGAACATCAGGAAAGAAGAAAGAACATGGTAAGCAAA AAT-------ATAGGT-------------------------------------------- AAATACAATAGGCTTTCCTTCTTCTCTTGAGTTTTCTAAATTATGTTTGAC--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AGTTGAAGCAAAATTT----- ------------------------------------------------------------ ---------------------------------------------TTATACCATCTTGTG TTGTGCTTCTAAACGTATGTAGAGAAAAATAATTCAATCAAATATAGGGAAGGGAAAGGG GCTTAAGGGAAGGTA--------------------------------------------- ---------------AGGTTTCTATA---------------------------------- ----------CTTCACTTGAACTGGTAAAATGATAACACC-------------------- ---AGTAGACTG------TGATAAGT---------TATGTATATATAATAT--------- -------------------AATACCTAGAGTAACCACTATA------------------- -------------------------AAAAACCGAT-----------ACATAAATTAAAAA TGCTAT------AGATAAATCAA------AA--------------TGGAGGTCTTACAAA ----TGTTCAAGTAAAACGCAGAAAGGAAAA-------AAAAAAAAC-----AGAAACAA A-ACACAGAACAAACAGAAAACAA------------------------------AAA--- ------------------------------------------------------------ ----------------------------------ATAAATAAATATAA------------ -------------TTAC-ATTAAATA-TAAATGGTCT--AAATATAAAAACAATAAAAAG AAAAAGAA--AAATAGAG-AGTAT---------------AAAAAAAAACCAAAAAA---- ---TAT-ATTTTCTAAAAAAA-ACTCACTT-CAAAT--ATAATAATATAGGCAGGTTGAA AG--TAAAAGAA--TGGAAAA-AGATATATCATGCAAACAT------TAATC-------- -------------AAAAG-AAAGCAG--GAGTGGCTATATTAATATC-AGATAAAGTAGA CTTCAGA-GC----------AAAGAAAATTACCAGAGAC-AGAG-AGGGACATTATAT-- ----AATGAAAAA---AAGGTCAATTCACC--AAGAAA--------AC-ATAGCAATCCT AA-----------------ATGTGTATGCACCAAACAACAGAGCTGCAAA--ATATGTGA AGCAAAAACTGATAGAACTGAAAGGAGAAATAGACAAATCCAC---------AATTATAG TTGGAGACTTCAATACCCCTC-----TCTCAATAATTGATAGA----------------- ----ACAACTAGA---------AA-----AATCAGCAAGGATATAGAAGAACTC------ --AACAACACCATCAACCAACAGGAT-CTAATAA--ACATTTATAGAA--CACTCCACCC AACAACAG---CAGAATACACATTCTTTTCA-------AGTGCCCAT---GGAACATATA C------CAAGATAGACCATATCCTGGGCCATAAAACAAA-------------------- -CCTCAACAAATTTAAAAAAA--TTGAAAT----------------CATACAGA------ -GTGTGTTCTCT---AACCACAATGGAA-TCAAACTAGAAATCAATAACA--------GA A-------------AG-ATAACAG---GAAAATCTCCAA----ACACTTGGAAACTAAAC AACACA-CTTCTAAA---TA-ATCCATG--GGTCA---AAAAAAAAAT--TCT-AAAGAT AAATAAAAAATAAATT---AAACT------------------------AAATAAAAATA- -AAATACAAA--ATATTAAAATTTTGTGG-GAAACAGTTAAAGCAGTGCTGAGAGGGAAA --TTTATAGCACTAAATGCATATATTAGAAAAG---AAAA--AAAGTCT---CAAATCAA ------TAATCTAAGCTCCCACCTCAA---GAACCTAGAAAA---AG---AAAAGCAAAA TAAACCCA-AAGCAAGCA------------GAAGAAAGGAAATAAT-AAAAATAAGAAAA AAAAAA---AAAAAAATAAAAATAAAAAAAA-AAA---AAAAAAAAATA-AATAAAATAA -AAAAC-------TGGTTCTTTGAAAAGATCAA--------------------------- -----------------------------------------------------------T AA-----AA------TTGACAAACCT---CTAGCAA------GACT-------------- GACAAAGAAAAAAAA---A---GAAA-AAACACAAATTAC-------------------- -----CAATA---T---------CAGGAATAAAACA------GAGGA---TATCACTACA G--------ACCC-TGCAGACATC-AAAAGAATA--ATAAA---------GGAAT----- -------------------ACTATGAACAA-TTCTACACACATAA--AT---TTGACAAC TTAG---ATGAAAT--GAACCACTTCCT--T---AAAAAA---------CAC-----AAA CTACCA------CAATTCACCCAATATGAAATAGATAATTTGAAT--------------- --------AGCCCT------A------TAACTATTAAGGAAAT----TGAAT--TTAAAA TTTTAAAACCCAATAAAAAAAAAAAA--CCACAAGGTC--AAATGGATTTAATAAAAAAA TTTTA------------CCAAAAATTA----AAAGAAAAATTAAAA-CCAATT-----C- ----TACATAATTTTTTCCAG-------AAAATAG-AAAAGAAAAA-----------AAA ATTTCCAAATTCATTTTATGAA---------GCTAGTAT---TACCCTGATACC--AAAA C-----------------------CAAAC---AAAACAAGAAA----AA---------AA AAAAAAAAAA---------------------AAA------AAACAATAT--CCC----TT ATGAATATAGAT------------------------ACAAAAATCC-TTAA--------- ------CAAAATATTAGC-AAATAG------------------AA--T------------ ---T-CA--GCA-------------ATATATAAA-------AAAAAATATATAAA--CCA -----AGC------------CAAAGGGG--TTTATTCCTAAAA-TAAAAA---------- ------------------------------ATTTAA----AAATTAATCAAATTATAATA AATAAT---------A------TTAG-------GATAAAGAAAAAAAAT---CACATAT- ----TTATA-------------------AAAACAGA-TAAAG---AATTTAAAAA---AA TTCAAAACCCATT-------------------CATTA---------T-AAAAAC-TCTCA --GAAAA------ATAAGAAAAAAAT-----TTCTTAAACTTAA---------------- -----------AAAAAACAT-ATAA-AAAAAACCTATAGC-----------TAACAT--T ATACTTAATGATGAAAG-A-----CTGAATGC-TTTC---CCCCTAAAAC----TAGGAA AAAAGCAAAGATGT-------CTACTCT-------------------------------- ------------------------------------------------------------ ------------------------CTCTTCTT---TTTAA-CATA--GTTAT---AGATG TTATTGCTAG--------CCAATTAAA------TAAAGAA---AAAAA--AGTAAAAAAA ATACATATAAAAAA-------GAAAGAAATAAAA--ATGTCCCTA-----TTTGCAGATG AC--ATGATTGTC-------TATATAGAAAATCCCAAGAAAACAAAAAAAAAAAAAAAAT CTAAAA---------AAA--ATAATCTAAAACT---------AATAAT--TGAGTTCAGC AAGG--TT-------------------------ACAGGATACAA--------------GA TAAACAT------------ACAAAAAT----CA------TTTCTATA-TATAATAA--CA ATAAACATATGGATTAAAAAATTTAAAATACAAAAAACATTAAAA----AATATAATACT ATTTATAATTA----TTAA---AAAAATAAAATTTTTAGGTATAAATAT--------AAA -AAAATTTATAAAGAACTTTA---TTGCTAAA--ACTTATAAAATAATAATG-AAAAAAA ---AATA-----------AG------------------ATCT--AAAT--AAATGGAGAG ATAT------A---ATGTGTTCATG------AATTAGAAAAATT-----AAAA-AAGTA- ------------------------AAGATGTCAA-TT-CTCCCC-AA------------- ----ATTGATATACAGG---TTTAACACAATTCCTATCAAAAT---------CCCAGCA- AG------------ATTTTT---------------------------------------- --TGTAGATATAG---ACA------AGATTATTCTAAAA-TTTATATGGAA-------AA GCAAAGGAACTA---GA--ATAGCTAAAACAAATTTGAAAAAGAAAAATA---AAGT--G -------GAAGGAATCAAT---CTACCCAATTTTAAAAC-----TTAATTAGA---AACT AAAATAAATCAAAATGGT------TGGAATAGTGGGAGA-----------------GAAA TAGAGACA------AATAAAT--TAAACAAACAAAATAGAGAACCC------AG--AAAT AGA---CCAAAAAAAAT-TG----CCCAAA--TAATTTTT---GACAAA--GGTAC--AA AAGCAATTC--AATGG-----AGAAAAG----ATAGC--------CTTTT--TAACAAAT GGTTCTT----------GAAACAAT--TGG-A-CATCCA---------------TAGGC- AAA---------AAA---TTAACCTCAACCTAA----GTCT---------------CACA CC--TTATATAAAAA-TTAATT-CAAAATATAACATAGATTTAAATGTA--AAATGTAAA ACT-TT------------------------AAAACTTTTAGAA----------------- ------AAAA--AAATA------A---------GAA---------AAAATTTTAGGAAA- --ACT-----AG-GATAGGCAAAGTGTTTCTAATTAA-CACCACA-AAA----ACAAAAC TCAAAATAGAAAA----A------AT---TAAT--AAA-TTAGACTTC--AT-------- -------------------------------------------------------CAAAA ATTTAAAATTT-TT-TT---TTGT-AAAAGACCCTGTTAAG-AGGA-TGAAAAG-ACAAG CTAT--AGAA--T-GGGAG--AAAATATTT---GCAAACCACATAT--------CCAACA AAAGACTAA-------TATCTAAAATATATA--AAGAA--CTCTC-----AAAAC----- ----------------------TAAACAATAA------AAAAAA------------A--- ATAAATACAA-TTAAAG-----AAGAAAATAGGAAGA-----------AAAAACAAAAA- ---AGAATTTTAACAGAATTGATTGAAAAGA--------------TGGCAAAT-AAACAC ATGAAAAGATTTTAGAAAACCTTTATTAG--CAATAGAGA-AAT--AAAAATT-AAAACC ATAATGAGA---------------------TATCATTACACACCTATCAGAATGGCTA-- ----AAATAAAAA---ATAGTGGCA---------AAAAGACAA--AAG--CTGGT-A--- ---------------AAGATGTAGAGAA-------------------------------- -----ACTGGATCACTCAT-ACTCCGTTGG--TGGTAA---------------------- ----------GATTATA-------------AAATG-TTCCACCA--------ACTCTGA- -------AAAGCA-TTTTGATA--TTTTTTTAAAAAAAAAAAAC--ATACAAACCATA-- -TATGA--CCCAAAAATTGTACTTCTGTG-TATTTACCCCAGAG--ACA--TGAA----- -------------------ATTTCACG-TGCAC--GTAAATTCCTG----------T--- ---------CAATT--CATCTAGATAACTGAAAAATT---ATATACACACAAAAACT--G GA--------ACAGAAA-TGTTTAT-----------------AGTAGCTTAG--TAAA-- TA---------------------------------------------------------- ------------------------ATATCT----ATAACATGG----------------- -TAAAA----------------------AGGAACGAAGTATTTATACAG----------- ------------------------------------------------------------ -GCTGAAACGTGAATAAAT-C---T----------------TCAGTGAATTTTTGTCAGT GA-------------------------------------------------------AAA C----------------------------------------------------------- ----------TACCA--AGCAA-------------------------------------- ------------------------------------------------------------ --------------------------------------------------TAAAAGTTA- -----------------------------ACAAACTCTTA------------ATA----- ------ACATT-------------------------------------------CTTGAA A-------T--------------GACAAA---------------A--------------- ------------------------------------TTATA-------------GAAA-- -------TG------------------------------------------GAGAAC--- -AGATTAGTGGT---TGCCA-----GGGGTTAAG---------GAGGGG--------GTG GGGGTGGGAGGG------------------------------------------------ --AAG-------TGGGTG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TGG----------------------CT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ATAAAAG---------------------------------------------- --------GGCAACA-TGAGGGAT--------------------------CCTTGTGGTG ATGGAA--------------ATGTTCTGTA--------------TCTTGACT-------G TAT-----------------------------------------------------CAAT GTCAGTATCCT------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GGTTGTGATA-- -------------------TTGTACTATAGT--------TTTGCAAGATGTTACCATT-- --------GGGGGAA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------ACTG-GGTAAAGGG----------------------------TACGTG------ ------------------------------------------------------------ ----------------------------------------GGATCTCTCTGTATTATTTC TTACAACTGCATGTGAATC------------TACAATT----ATCTCAAAA------TA- -------AAAAGTTTAATTTAAAA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1ME2 -----------------------------------AAGAATG--GAGCAGA-AAAAATAT TTGAAAA-------AATAATGG--------CTGAGAATTTTC------------------ ---------------------AAAA---------ATTGATGAAAAAAAT--------CAA CC--CACAGATCCAA-----GAAACTCAGAGAACCCCAAGGAAA-----------ATAAA TACA---AAGAAAACCACACCTAGGCACATAATGT--------------CAAACTGCTGA AAACC----------------AAAGATAAAGAGAAAATATTAAAAG-------------- ------------CAGCCAGAG-----------------AG--AAAAGACAAAAACATTAC A-------------------------------------------TAC-----AG-AGAAA CATTGAAA-----------------------------AAAATTA-ATAGTTGCCTCCTTT TAAGAAAAAATTAAGCCAAAAAACAAGTAAATAACATCTTTAAAGT--------GCTGAA AGGGAAATATCAACCTAG------------------------------------------ -------------AATTCTATATCCAGCGAAA------------------ATATCCTTCA AAAATGAAGGTGAAATAAAGA---------CATTTTCAGATAAACAAAAGCTGAG----- ------------------------------------------------------------ -------------------------------------------------AGAATTCATCA CCAGAAGACAT------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GCACTACAAAAACCACAAACAACCATAAA----------- -ACTGGACAAAATATATGAAT--------------------------------------- ------------------------------------------------------------ -----CATTGGTCATCTGCTGCTGAAAAA--------------GAGGCAGAAAA------ -------------------ACAGATCTTACTCAGA----------------AAATTGCAA TG-------------AGTTTAAGGGCACC------------------------------T GATGATTTCTGTG---------------GGGCTATGGCCAGAACCCATCC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CCAGCTCTGGAA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TAAGAAATGAGTATGCAAAAGAA---- ---------GAA------------------------------------------------ ---------------------------CTATGATCCTTTTTGAGGTAAAGAAAGTAGGGC --------------------------------------------------------CAAA GCTAAACCCCC---CTGAGGCAC-----CA-----GTATTCTG---------------GA CAGCAGAAGA--CTGTCAT----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------CAGAG AGGCTT-----------------G------------------GCCTTATATTCAGCAATA TGTAGGATT----------GAATCTCTAGATGAGTGGCGGGGAGACTGTGA--------- ------------AAGGCGT----------------------------------------- ------------------------------------------------------------ ----------------------------------------------CTACCATAAAAAAG A---GCACTCTGAAGTATAAG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAAGCAACGGCTA------------------------AGT G-----------ATTGAAAGCAGAACTGTAGG---------------------------- ------------------------------------------------------------ -----ACAAGGATTTAGTATGTGG------ATAAGGATGTAAGAGTTAT----------- ------------------------------------------------------------ -----------GACAAAAC----------------------------------------- ------------------------------------------------------------ --------AA-AAGTAAGA----------------------------------------- ---AAATTTGACTATCGCCTT--------------------------------------- -----------------------------CCGAATAATTCTAAG---------------- ------ATAGCAGT----------------------------AACAAAGGTCCCTCGGGA GTTACTTCCCCTCAGAAGTAAAGTCCACACCTTGGAGTTAGATCTACTCT-------GGA CCAGCCTTAACCAAGCCAA-------AAC-CAAGCCCTGA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CGA-GATCTTTA AAATTGAGAATTTGGAGA------TAAAA------------TATAATAT---TAGAGGAA CTGAAGA---AATGTCTTTGGTTTTCCACAGATCAATC---------------------- -------------------------------TAAAAACAAACAA---AATAAAGC----- ----------------------------------------C------------------- --------------TACACAATTTA---AAGGGGGAAGC--------------------- ----------------------CAAAA-------------CAAGCTCA--AATACAAACT ---------------------------------------------AGATA---------- -----CTAACTAAAC--------------------------------------------- ------------------------TTCC-AACA----TTAAA---------AAAAT---- -GATAAAAGAA----GAGAATTATACATTTT--AAGTCGGAA------------------ --------------------------------------------TCTCCACATCACTAC- -----TCTCTATTACC--------------------------------AATA-AGT-TAT AAAAATC----------------------------------------------------- ------------------------------------------------------------ ----AATATAACATTAACAGAAA----CAGGCAC-------------------ACAC--- ------------------AACTGCAAATAAACTAAAAATAATAAAACCAAA--------- TGA-CCATAGAAAAAAA--AATTCATAGTGCCCGAACA-----------CAGAGGGCGCA AACATTGAACTTAACTGACACATAATAGAAA--------------------AAAAGTATG AAACAAATACT----------AAAAAATATCTGA-AA--------GCAGTTATACAGT-A TATACATGTCTAGTATATATAGCACAGAAGTAAAAGAAAAAAAAACAGAGCAATATCAAA ATGCAAGAAAGGAAGAACAGAAAATTTGACGTAA-TAGAT--------TCAGTGAATGAA CTTATTAAGAAAT-----TGGATCCGGCAG----------------------------AG CAGGAAATCAATAAATT----------TAAAGACACGTCTATAAAAATGA---------- ---------GTCAAACTGAAAAAAAA---------------------------------- --------TGAAAATAAATAGAAA---AATAAAAA------------------------- -------------AGGG--------------AAAATTTGATGCTAGGATAC------ATG ATT------------TACAGGA--AACACA-GAAA----AGGAAGATCCTG--------- ----GAAGAAGGAAA-----------------T-GAT-ATAAAAAAGA------------ -AAT-TTAGATA--TATTTGAA------------------------ATGTAAGG------ --GCTCAAATACAT-----TTCA-AAAATAA-------GGT-GTAAATATAAACATATTC AGATAAAT-GAAAGCTGAGCTG-ATTCATCACCTAAATGC---CTGTATTAC-AAGATAT GTT--------------AAACAA----------------------CCATC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TACAGGATAAAGAAAAACAATATCAGGTGGCAATT -----------TAAAT--------------------ATTTATATAGAAATGAAATAAATT GAAAAAAGGAAAGTTGATTGAAGGGATTTTCTTTCTCTCGTAAGTTAATGT--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AAAAATAATAAAATTAAAGGC AGGGTTAAAA-------------------------------------------------- --------------------------TGTATGTCGAGGTAAAGAAATAACAACAATGGTA CAAGGAAACGCAAAGGGTTACATTTGTGAAGTGGGAACTGTGAAAAATATAGACAAAAGT AGAAAGATATTTTCTTATGAAGAGAGAGATGTAATGTGATAGATGTGAAGTG-------- ------------------------------------------------------------ ----------CTATATGTGAAGTGGTATAATATTAACTCT-------------------- --AAATAGACTG------TGATGGTCAAATT---TAAAGATTACATATTGT--------- -------------------AATCTCTAGAGCAATCACCAAAAAAAATAGAACGAAGAAGT AGA---GCTCTTGTATAGCTAATAAGTCAATAGAA-----------GAGATAAAATGGAA CCCTA-------AAAAATTTTAT------T---------------TCAC-----CTCAAA ----AA------GTACAGGAAAA----GGGA-------GAACAAATA-----AACAAAGA TCAGATGGGACAAATAGAAAACAAATTGC--------------------------AA--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAATG-TAGA-----------------CTTATTTAACAG ATAGTCAG--------AC-TGGAT----------CAAAAAAAGCAAGACTCAACTA---- ---TTT-----GCTACATGAA-ATACATTT-TAAAT--ATAAAGACACAGATAGGTTGAA AG--TAAAAGGA---TGAAAA-ATATATACAATAAAAACAC------TAAGC-------- -------------ACAAG------AATGGTGTTGCTATATTAATATC-AGATAAGGTAGA CTTCAAG-AC----------AAAGAATATTACCAAAGAT-AAAG-AGAGAAATTGTAT-- ----AATTATAAA---AGGGTCAATTTATC--AAGAAG--------AC-ATAAATACCAA AA-----------------ATATGTTTGCACCTAATAACAGAGCTTCAAA--ATACATGA AGCAAA-ATTGATAAAACTAAAGGGAAACATAGACAAATTCAC---------AATTATTA GTGGAGATTTTAAAATCTCTC-----CTCTAAT----GATAAA----------------- ----ATAATAAGACAAAACAAAAC-----AGTCAATGAATATA----------------- ------------------------AA-CTAATTG--AAATTTAT-GAA--CAACCAATCT AACAACTG---CAAAATACACATTTTTTTCA-------AGTGCACAT---GGAACATTCA C------CAAGATAGATCATATGCTGGGCCATAAAACAAG-------------------- -TCTCAATAAATTTCAAAGGA--TTAAAAT----------------CATAA--------- -ATATGTTATTTGACAATCATAATAGAA-TCAAATTAGAAATCAATAACA--------AT A-------------AG-ATATATA---GAAAATTCCCCA----ATATTTGGAAATTAAAC AATACT-CTTCTAAA---TAACCCCATG--AGTAA---AAGAAAAAA---CAA-AAAAGA AATTAGAAAATATTTT---AAACT------------------------GAATGATAATAA -AAACACAAC--ATATAAAAATTTG-GGG-AATGCAACTAAAGAAGTCTTTAGAGGGAAA --TTTATAGCTTTAAATGCTTATATTAGAAAAA---AAGA--AAGGTAT---AAAATAAA ------TGATCTAAGTTTCCAACTTAA---GAAGCTAGAAAA---AG---AAGAACAAAT TAAAACCA-AAATAAGAA------------AGAAGAAAGAAATAAT-AAAAAATAAAATA AAAAAA---AAAAAAAAAAAAAT--AAAAAATCAA---------------AACAAAGCCA -AAAGT-------TGGTTCTTTGAAAAGATTAA--------------------------- -----------------------------------------------------------T AA-----AA------TTG--AAACCT---CTAGCAA------GACT-------------- GATCAAGAAAAAAAA-------AAGAAAAAAACAAATTAA-------------------- -----CAATA---T---------CAGAAATGAAAGA------GGGGA---TATCACTACA G--------ATCC-TACAGACATT-AAAAGGATA--AT------------AAAAT----- -------------------ATTATGAAAAT-ATTTATGCTAATAA--AT---TTGACAAC TTAG---ATGAAAT--GGACAAATTCCT--T---GAAAAA---------CAC-----AAA TTACCA------AAACTAACACAAAAAGAAATAGAAAATCTGAAT--------------- --------AGCCTT------A------TATCTATTAAAGAAAT----TGAAT--TTATAA -TTAAAAACCTTCCCAAAAAGAAAAT--TC-TAGGCCC--ATATGGTTTCACTGGTGAA- TTCTA------------TCAAACATTT----AAGAAAGAAATAAAA-CTAATA-----T- ----TACAAAAACTTTTTCAA-------AAAATAG-AGGAGAAGGG-----------AAA ATTTCCTAACTCATTTTATAAA---------GTCAGCAT---AACCCTGATACC--AAAA C-----------------------AAGAA--AAGGA-----------AA---------TA AAAGAAAATT---------------------ACA------GATCAATAT--CTC----TC ATGAACATAGAT------------------------ACAAAAATCC-TTAA--------- ------CAAAATATTAGC-AAATAA------------------AA--C------------ ---C-CG--ACA-------------ATATATA---------AAAAGGATAATACA--TCA ----TGAC------------CAAGTGAGG-TTTATCCCAGAAA-AGTAA----------- -------------ATTGGTTTAAAA-----ATTAAA----AAACCAATCAATGTA--ATT CACCAC---------A------TTAACAG----AATAAAGGAGAAAAAT---CATATGA- ----TCATCTC---AATA----------GATGCAGA-AAAAG---AATTTGACAA---AA TTCAACACCCATT-------------------CATGA---------T-AAAAAC-TCTCA --GCAAACTAGAAATAGAAGGGAACT-----TCCTCAATCTGAT---------------- -----------AAAGGGCAT-CTAT-AAAAAACCTACAGC-----------TAACAT--C ATACTTAATGGTAAAATAA-----TTAAATGC-TTTC---CCCCTAAGAT----TGGGAA CAAGGCAAGGATGT-------TCACTCT-------------------------------- ------------------------------------------------------------ ------------------------CTTCATTTCTATTCAA-CATT--GTACT---GGAAG TCCTAGCCAG--------TGCAATAAA------GCAAGAA---AAAAA--AATAAAAGGC ATAAAGATAGGAAA-------GAAG-AAATAAAA--CTGTCTGTA-----TTTACAGATG AC--ATGATTGTT-------TACATAGAAAATCCT---------------AAGGA---AT CTACA----------AAA--AACTTCTAGAAAT---------AATAAG--TGAATTTAGC AAGG--TT-------------------------GCAGGATACAA--------------GG TCAATAT------------ATAAAAAT--------ACTATTTTTTTA-TATTGTAA--CA ATAAAAAAATAAA------------------AAATAAAA-TTTTA----AAAACAAT--- ATTTTCTATAAC-ATCTAA---AAACATAAAATATTTAGGAATAAATAT----------- -AAAAGATATGCAAAACATCT---ACACTGAA--AACTATAAAATATTGATG-AGAGAAA TTAAAGA-----------AG------------------ACCT--AAAT--AAATGGAGAA ATAT------AGAGATATACT-ATG--------TTGAAAAATTC-----AATA-TTGTT- ------------------------AAGATGTCAA-TT-CTCCCC-AA------------- ----ATTGATCTATAGA---TTCAATGCAATTCCAATCAAAAT---------CCCAGCA- GT------------TTTTTT---------------------------------------- --TGTAGAAATTG---ACA------AGATGATTCTAAAA-TTTATATGGAA-------AT GCAAAGGACCTA---GA--ATAGCCAAAACAATTATAA---AAAAGAACA---AAGT--T -------GGAAGACTTACA---CTACCTGATTTCAAGAC--------------------- ---------TAAGAT-AG------CA---------------------------------- --------------AATAAAT--CAATGGAACAGAATAGAGAAACCAAATCAAG--AAAT CAA---ACAAAAAATCTACA----GTCAAT--TGATTTTT---GACAAA--AGTAC--CA AGGAAATTC--AATGG-----GAAAAGTAGAATTTTT--------CTCTT--CAAAAAAT TGTACAG----------A-AAGAAC--TAG-C-TAAACA---------------TAAGA- AAA---------AAA--ATGTACCTTGAACTCT----AAAC---------------TTAA CCCTATA-ACAAAAA-TTACTTGAAAAATGAATCATAGATCTAAATATA--AAAGCTAAA ACT-AT------------------------AAAACTTACAGAA----------------- ------GAAA--ACATA------G---------AAGTTA------AATATTTTTGTAACC TTCTT-----GG-CGTAGGAAAAGATTTTCTTAGACA-GAAAAGA-AAA----AAAAAAA CCATAAAAGAAAA----A------AA---TGAT--AAA-TTTGACTTC--AT-------- -------------------------------------------------------CAAAA TTAAAAAATTA---TCA---TAATTAAAAAACAACATTAATAAAAA-TATAAAA-ATAAC CCAT--------TATGGAA--GAAAGATGA---GCCA---ATTCAC--------CA---A AAAATTGAA-------TA----------GAA--AAAAA------------ATAAA----- ----------------------CCAATAAAAA------ATAAAA------------A--- AAAAACTAAAAATAAAA----------AAAAAAAAAA-----------AAA--TA----- ---AAACCATT----AAAAAAAATATACAATAATAT---------TGGCAATTAAAGCAT CAAAAAAAATG----CTCAACATCATTAG-TCATCAGGGA-AAT--GCAAATT-AAAACC ACAGTAAGA---------------------TACTACTATAAATTGACTAAATTGGGTA-- ----AAATAATAA---AAAAAGACA-----------ATACTAA--ATG---TGGTAA--- ---------------AGAATGGGAAGCA-------------------------------- -----ACTGGAATTCCCAT-GCATTGTTGG--TGGGGG---------------------- -------------TGTA-------------AAATG-GTACAACC--------ACTTTGG- -------AAAAC-----TAGTA--AGTTTTTTAAAAAGTTAAAA--ATACATTTACCA-- -TATGA--CCCAGCAATTCAACTTCTACC-TATTTA-CATAAAAAAAAG--AGAAATA-- -------------------AAAATCTT-TAAAC--AAAAAAACTTG----------T--- ---------ACATG--ATTGTTGATACTATCTTTATT---TATAATA-ACCACAAACT-A GAA-AAAA--ACCCAAAATTTCAAC-----ATAAGAG-----AATTGAAAAA--AAAAAT TG---------------------------------------------------------- --------------------TGATTTATTC----ATACAATGGAATAC--TACTCA-G-- -TAAAA----------------------AAAAACAAACTAATAAAACTT----------- ------------------------------------------------------------ -------GCATGGATGAAT-C---T----------------CAAAAATATGATGATGA-- ------------------------------------------------------------ ------------------------------------------------------------ --------------A--GTTCT-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAACA---- -----------------------------GGCAAAAC-TA-------------------- ------------------------------------------------------------ --------A-----------------------------------T--------------- ------------------------------------CTATG-------------GTGA-- -------TA------------------------------------------GAAATC--- -AGATCAGTGGT---CGCCT---------CTGGG---------GGGGGG----------- ----------GG------------------------------------------------ --GGG-------AGCATG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TGT---------------------GTG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------TGAGATG---------------------------------------------- --------AGTG---------------------------------------TTAGATAGA ATTAAC-------------------------------------------TGC-------A AAG-----------------------------------------------------GGGC ATGAGG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GAACTTTCTG-- -------------------GGGTGATGGAAA--------TGTT----------CTATA-- ------------------------------------------------------------ ------------------------------------------------------------ -----------TCTTGATT------------------------------GTGGTGTTGGT TACACGGGTG-TATACA-------------------------------TTTGTC------ ------------------------------------------------------------ ----------------------------------------AAAACTCATCAAACTGTACA CTTAAGATCTGTGCATTTTATTGTATGTAAATTATACC----TCAATAA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1ME3D ------------------------------------------------------------ -------------------------------TTCAAAAATAC------------------ ---------------------AAAA---------AAAATAAAAAATAAT--------GAT TT--TAAAAAAAAAA-----ATATTTAAATGCATGTCTGAACTG-----------GTGA- ------------------------------------------------------------ ---------------------GAAAATAAAGAAAATTAATTGAAAG-------------- ------------CCAGAAATG-----------------AA--AAG--------------- --------------------------------------------AAA-----GG-AAAAA TGCAGAAAGG-------------------------------------------------- ------------------------------TAAGCAACAATGAAACCATC---------- --ATATATTCTGAGGGTATTAGCC------------------------------------ ---AAATCATATTAACTTAAATCTTAATTTTG------------------ATAAGTTTTC ATGATAAAAAAAATAAAAGAG--------------------------------------- ------------------------------------------------------------ -------------------------------------------------------AAGGC TTAGGGTCCGATA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AAAGTGAGGAAATAAATAAAACCTTA-------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------AATAAAGCTGAA--------------ATCCCAAAA-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------TCGAATAATAAATAAAAAAAAAACTTCATGCAGAGGAA AACAGAGTGAC------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------AT------AAATTTC--TACTAGGTATTAACAAAAATAAATAATGGGGA---- ---------AAA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AAATT AATCAT------------------------------------------------------ -----------------------------------------GAGACAATCA--------- ------------AAATCCAAAAT------------------------AAATAATTTTTTA GGAAA-------------ATACA------------------------------------- --------------------------------------------------------AATT A---TATAAATTGATTGGAAAAACA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAACCAA------------------------------ATA A-----------AAAAATTAAATTTAAATAGATAATTG---------------------- ------------------------------------------------------------ -------ATGGATATCGTCTCTAG------------------------------------ ------------------------------------------------------------ -----------AACAACTC----------------------------------------- ------------------------------------------------------------ --AAAAAGAA-AATTTAAA----------------------------------------- ---TCAAATATTTATGAACAT--------------------------------------- ----------------------------------AATTTAAAAA---------------- ------AAAAAAAAAAAATAAAAAATAAAAAA-------GGAAACAGAAAGAAAAAAGAC AGCA-----------------------------AAAAATACAA----------------- ACAG-------------------------------CAGAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TCAGTTATAAAA AACT------CATAAATA------TAAAA------------TATAAATA---AATGAA-A ATAAAAAAAAAAAATATTAAACT----AAAAGTATGTA---------------------- -----------------------------------------------AAAGAAG------ ------------------------------------------------------------ -----------------AAAAAGAA---AGTCAAAAATT--------------------- ----------------------AAGCA-------------AACA------AAT------- --------------------------------------TTGTAAAAGAAC---------- -----ACAGTAGAAG--------------------------------------------- ------------------------TTCT-AAAAA---TGGAA---------ACTAT---- ----AATTGAA----ATTTAAATTTCAATGA-------ATGG------------------ --------------------------------------------ATTTAACAGGAGATT- -----CAGGA--CAGT------------------GAAAG---------AGAG-AAT-TAG TGTACTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGATAGAACTGAAGAAA-T--TATCCAAACT---GCAG---------TGCA--- ------------------AAAAAAAAAAAAATTAAAA---ATAGGAAAGAG--------- ATG-AAAAGATATA-----GAAAGATTAGAATG----------------AAAAG--ATCT CACGTAAGTG-TAATAAG--AGCTCCAGAAG--------------AAAATAAAAATAGAG AGAATGGGCAAG---------AAGCAATATTTGA--A--------GAGATTATGGC-T-A AGAATTTTCTAGAATT--------------------GCTGAAAGACACTA--AACTTCAG ATCC-----AGAAAGCCCAATAAAT---TCCAGG-CAGAA--------TAA--------- ---A-TATAAAGA-----AAACCTCACATA----------------------------CA CACAAGATATCTAAATTTCAAACTGC-TGACA---------ACGAAAATG---------- ------------AAG--AAAAAATATTTGAAAAAATTATGGCCAAATTTTCCCCAAATTT GGGGGAAATAAAAATAACTTCAGA---AAAAAGACAAAATTCCCCAAGAAAATCACCACT CATAGGCATATTAAAAGAGAAAAACAAAAAAAAAAAAAAAT-CTAGACTGA-T--GGCTG ACTATAAA---GATCGGCTGAC--ATTAAAACATA---CATTGAAGCACAG--------- ----GAG---ATTAA-T-------TTAATCAGT-ATT-CAAAGAAAAAATACAGTGTAAT AAAATTTTTTCACCACCAAAAATAAAATTTTTTTGT----------ACCCAAGAACAAAT AGGGCAAAATAAGTATATGTTCAGAAAAAGA-------A---AGAATGAGAGTGTTTTT- ---CAAAT-AAAAGGAAATAGACCCTTACTAACGGCAGAT---CTGTACTATAAAGAAAT TCT--------------AAAGGA----------------------TATAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TTCAGGAAGAAAGAAATCGTTGGAAGAT ----------CTAAAT-------------------------------------------- --------------------------------------------------A--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AAAAGCTGAAAAATTTGAAAA AGAATTAGCAAGGGGAGG------------------------------------------ -------------ATAAAAACAAATGAACAAAAATGTATAGAAAAGTATAATTTGTGAAG TTTAAAGAAAAAAGGAATAACAATCTAACTAACGAGGAATAATAGTATATAAGTTGGGAG GGG--------------------------------------------------------- ------------------------------------------------------------ ----------AATAATTGAAGTTAAATTATTCTAAGGTCCTTGTATTGTTTGGGAGGAGA GTAAAAAAACTA------ATAAATTTATACTATATTAAGAATGCTTGTTAA--------- -------------------AATATCCATGGTAACCACTAAA----------ATAATAGAA ATACAGAGTACAACATTCAAACTAGTAGAGAGAGA-----------AAATGGAATGAGA- ------------AAAAAAATGAA------A---------------AAAA-----CTTAAA ----AA-------AAACAACCAAATAGCAGG-------AAAAACAGG-----AAAAGAAT AAAGATAGAACAAATAGAAAGTACATAAG-------------------------AAA--- -------------------------------------------------ATGGTA----- --------------------GAATTTA--ATTCAAAAAAGATCAAATA------------ -------------GTAA-AATAAACG-CTAAAGGAAA--AAACCC---TCCAGTTAAAAA TAAAAGAT--TGTTAGAC-TAGAT------------TTATATAAAACCACTATTTGGTGC TGATAAATATTCATATAAGAATATCC---T-CTAAC--ATAAGGACACAGAAAGTTTGAA AG--TAAAAGGA--TGAAAAA-AGATATGCCAGGCAAATAC------TAAC--------- -------------AAAAG-AAAGCTG--GTATAGCTATATTAATAAA-AGACAAAATAGA CTTTAAG-GC----------AAAAAGTATTAGTAGAGAT-AAAG-AAGGTCACTACTT-- ----AATGATAAA---AGGTTTAATTTACC--AGGAAG--------AT-ATAACAATTCT AA-----------------ATTTCTATG--CCCAATAACATGGCTTTAAA--ATATATAA AGTAAAAATTGACAGAACTACAAGGAGAAATTGACAAATCCAC---------AATCATAG TGGGAGATTTTAACACAACTCCTTCATTTCAGAAATTGATAGA----------------- ----TGGAGCAGAC----AAAAAA-----AATCAGTAAGGATATAGAAGACTTG------ --AACAGC-------ATAAGCTTGAT-CTAATGGAAACACATACAGAA--CACTGCACTC AACAATTA---CAGAATACACATTCTTTTCA-------AGTACACAT---GGAACATTTA T------GAAAACTGACCACACTCTAGGCCATAAAGCAAA-------------------- -CCTCAACAAATTTCAAAAGA--TTGGTAT----------------CATATAGA------ -TCATATTCTCT---GACCACAATGCAA-TTAAGTTAGAAATCAATAACA--------GA A-------------AG-ATAACTA---GAAAA-ATCCAT----ATATTTGGAAT-TAAAA AATACA-CTTCTAAA---CA-GCTCATG--GATAA---AATAAGAAAT------------ AACTAAAAAAAATTTA---AAACT------------------------GAATGATAATGA -AAATACTAC--ATATCAAAACTTG-TGG-GATTCAGATAAAGTAGTACTTAGAGGGAAA --TTTATAGCCTTAAATGCTTACATTCAAAAGG---AAGA--AAGGCTT---AAAATTAA ------TGAGCTAAGCATCTATCTTAA---GAAGTCAGGAAA---A----AACAGCAAAA TAAACCCA-AAGAAAGTA------------GAAGAAAGAAAATAAT-AAAGATAAGAACA GAAATT---AATGAAATAGAAAACAAACATA-CAA---TAGAAAGGATT-AACAAAGTCA -AAAGT-------TAGTTCTTT-AAAAGACTAA--------------------------- -----------------------------------------------------------T AA-----AA------TTAATAAACCT---CTGGCAA------GACT-------------- GATTAAAAAAAGAAAAA-AAGAGAGA-AAGCACAAATAAG-------------------- -----CAATA---T---------TAGGAATGGAAAA------AAGGA---CATAACTACA G--------ATGC-TGAAGAGATT-AAAAAGAT-----AAG---------AGAAG----- -------------------GTTAT-AACAA-CTTTATGCCAAAAA-AAT---TTGAAAAT TTAG---ATGAAAT--GGACAAATTCTT--A---GAAAAA---------TATAACTAAAC TTATCA------AAACTGACTCAAGAAGAAATAGAAAACCTGAAT--------------- --------AGTCTT------A------TAACCATTAGTAAAAT----TAAAT--CAGTGG -TTAAAAATCTTCCCACAAAGAAAAC--TC-CAAGCCC--AGATGGCTTTATAGGTGAG- TTCTA------------CCAAACATTC----AAGGAACAAACAATT-CCAATC-----T- ----TACACAAACTCTTCCAG-------AGAA----AAGAAAAGGA-----------AAT ACTCTCCAACTCATTTTATGAG---------GCTAGCAT---AACCTTGATACC--AAAA T-----------------------CAGAC--AAGGACA-GTAC----AA---------GA AAGGAAAATT---------------------ATA------GGCCAATCT--CTCCTAATC ATGAACATAGTT------------------------CCAAAAATTC-TAAA--------- ------CAAAATATTAGC-AAACCA------------------AA--T------------ ---C-CA--GCA-------------ATGTTT----------AAAAAGATAATACA--TCA ----TAAC------------CAAGTTGGG-TTTATCCCAGGAA-TGCAAG---------- -------------GTTGGCTT-AAT-----ATTAGA----AAATCAATTAATGCA--ATT CATCAC---------A------TTAACAG----ATTAAAGGAGAAAAAC---CATATGA- ----TCATCTC---AATA----------GATTCAGG-AAAAG---CATTTGATAA---AA TTCAACATCCATT-------------------CATGA---------T-AAAAAC-TCTTA --GCAAACTAGGAATAGAAGGAAACT-----TCTTTAACCTGAT---------------- -----------AAAGGGTAT-CTACAAAAAAATTTACAGC-----------AAACAT--C ATACTTAATGGTGAAAC-G-----TTGAAAGC-ATTC---CCTTTGAGAT----CAGGAA CAAGACAAGGATGT-------CCATTAC-------------------------------- ------------------------------------------------------------ ------------------------CATCACTTCTATTCAA-CATT--GTACT---GGAGA TCCTAGCCAG--------TGCAGTAAG------ACAAGAAAAAAAAAAATAATAAAAGGT ATAAAGATTGGGAA-------TGAAGAAACAAAA--CTGTCATTA----TTTTATAGATA AT--ATGATTGTA-------TACATAGAAAACCCA---------------AAAGA---AT ATACAG---------ATA--AATTATTAGAATT---------AATAAG--TGAGTTTAGC AAGA--TT-------------------------GCTGGATACAA--------------AA TCAATAT------------ACAAAAGT----CAATTTCATTTCCACATTACACCAA---- -----CAGTTAGA------------------AAATATAATTTTAA----AAAA-----CC ATTTACAATAGC-AACAAA----AAAAAAAAATACCTAGGAATAAATTT--------AAA ACAAAGATATGTAAATCTTTT---AGGAGAAATCAATTAAAAAATTTTATTG-AAAGACA TTAAAAA-----------AC------------------TAAA--TAAT--AAATAGAGAG ATAT------A---CCATGTTCATG------GATAGGAAGACTC-----AATA-TTATA- ------------------------AAGATAACAA-----TCCTC-AA------------- ----ATTGATCTATAGA---TTCAATGCAATTCCAATAAAAAT---------CCCAACA- GG------------ATTTTT---------------------------------------- --CATAGAACTTG---ACA------AGCTGATTCTAAAAATTTATATGTAA-------GA GCAAAGGGCCAA---GA--ATAGCCAAGACGCTCTTGACGAAAAAAAA-----AAAT--G -------GGAAGACTTGTC---CTACCAGATATCAAGAT-----TTATTATAA---AGCT ATAGT-AATTAAGAA-AG------TGTGGTATTGG--CG-----------------CAGG GATAGACA------AATAAGC--CAATGGAACAGAATAGAGAGCCC------AG--AAAC AGA---TCCATGCATATATG----AAAACT--TGATTTAT---GACAGA--GCTGG--CA TTGCAGAAC--TATGG-----GGAAAGG----ATAGA--------CTTTT--CAATAAAT GATGCTT----------G-GACTAT--TTATG-TTTCCA---------------TATGG- GGA---------GAAAAATAAAATTGGATCCCC----TCTT----------------TCA AGAAACACACATAAAATCAATT-CCAGGTGGATTAAAGACTTAAA-ATA--AAATTTGAA ATTTAA------------------------------------------------------ ------GAAA--CTATA------G---------GAG---------AATATCTTTATGAC- --CTC-----GG-GGTAGGGAAAATTTTCTTAAACAA-CACACAA-AAA----G-ACTCC ACATAAAGGAAAA----T------AT---TGAT--AAA-TTCGACTAC--AT-------- -------------------------------------------------------T-AAA ATTAAAAACTT-CTGTT---CATC---AAGAGACAA-CAAA-GAGG-CAAAAAG-ACAAG CCAC--AAAC--T-GGGGG--AAGATATTT---GCAACACATATAA--------CAAACA AAGGACTAG-------TATCCAGAATATATA--AAAAT--CCT-------ATAAA----- ----------------------TCAATAAGAA------------------------A--- AACAACTTTA-TAGAAA----------AATAGGAGAC-----------AAA---ACACAC ---AAACATTTCACAGAAGAGGAAACACAAA--------------TGGCTCAT-AAACAC ATGAAAAGATG----CTCAACCTCATTAG-TAATCAGGAA-AAT--GTAAATT-AAAATT ACA-TGAGA---------------------TACTATTTCATACCCGCCAGATTGGCAA-- ----AACTTAAAA---AATTTTACA-----------ATATCAA--GTG--TTGGC-A--- ---------------AGGATGTAGAGCC-------------------------------- -----ATGGAAATTCTCAT-GCACTGCTGG--TGGGAG---------------------- ---AATAAGTTAATGTA-------------AATTG-GTACAATC--------ACTTTGG- -------AAAACT-ATTTGGCA--TTAC-CTAGTAAAGTTGAAC--ATGCAAATTCCC-- -CATGA--CCCAGCAATTCCATTCCTAGG-TATATACCTTAGAGAAACT--CTTA----- -------------------CACATGTG-CACCA--GAAGACATGTA----------C--- ---------AAA----AATGTTCATAGCAGCATTGTT---TATAATA-GCCCAAAACT-G GA--AGCA--ACTCAAA-TATCCATCA---ACAATAG-----AAT-GATAAA--CAAAT- TG---------------------------------------------------------- --------------------TGGTATATTC----ATACAATGGAATAC--TATACA-GAA GTAAAA----------------------ATGACTGAACTACAGCTACAT----------- ------------------------------------------------------------ -GCATCAGCATGGATGAAT-C---T----------------CAAAAACATTACGTAGAG- GA-------------------------------------------------------GAA A----------------------------------------------------------- ----------AGCAA--GTCAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAACA---- -----------------------------ATACATAC-AGTATG--------ATT----- ------CCATT---TAT---------------------ATAAAGTTCAAAA---CCAGGC AAAACTAAACAATACATTGTTTGGGGATA---------------C--------------- ------------------------------------ATATATAGGTGGTAAAACTATA-- -------AA------------------------------------------GAAAAGCAA AGGAATGATTAA---TACAAAATTCAGGATTGTGGTTACCTTGAGGAGG----------- --GGAATGTGGC------------------------------------------------ --TAGCTTTGATAGGGGA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TGG------------TCATACAGGGAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CTTCGAG---------------------------------------------- --------GGTACTGATAATGTTC---------------------TATTTCTTAAGCTGG GTGGTA-------------------------------------------GGT-------A CAT-----------------------------------------------------GGAT GTT--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CAGTTTATTA-- -------------------TTATTCTTTAAA----------------------CTATA-- ------------------------------------------------------------ -----------------------------------------------------------T TTACA-----TACACTCTT----------------------------------------- ------AATT-TGCATA-------------------------------TGTACA------ ------------------------------------------------------------ ------------------------------------------------------CGTTTC ATATATTTTTGTATATATG------------ATATATT----TCACAATAA------AA- -------TA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MD2 --------------TTTAAAAAGAAATAAAGGCTTCCACTTCTGGCCAAGA-TGGAGTAA CAGAGACCAATTTACTCTCATG--------CTTGAAACAACC------------------ ---------------------AAAA----------AAACAGACAAAATA--------TAT GA---AACAATGGTTTTTAAGACACTGGATATCAGGCAATGAAGGGCAGTGATCTCTCAA TGA----TGGTAAACAAATTAGGTAAGTCCTGCGATTGCTCCAGCTTACCTCCTTGAGAG AGTTTCCAGGCTGTGGTGCA--GGGAGGAAACTGGGCAGAGCCTGG-------------- -----CAAGTTCCCTGAGTTG-----------------AG-------------------- -------------GAGATGAGCTTTGAATC----------------------GG-GAAGA CCAAGACAGAGTTTAT-----------ACAACAGAGTACCAACAAGGAGAAAACTGCACA A---------------------------------------AGAAAGCCGA----AGACCT GCAGAGGGTCCCCTTGGAGTATCC------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------AGCAGAG TACTGATCAGTACATGCATGTGAGAAAACCACCCA------------------------- ------------------------------------------------------------ ------------------------------------TTGCCAGGAAAAGAA--------- -------------------CTCCTCAAAAGGATTAGAGAG-------------------- ---------------AAGAGT-------------------ACCCGGCACTCACAAAG--- ------------------------------------------------------------ ----------AGTGGGGAATAATGCCTGT--------------TCCCACAAACCAA---- ------------------ACTGGAAAACCTCACAA----------------TTTACAGGG CT-------------------------------TTGGGT--------------------- -------AGAGTG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CTAGGAAAGTCTTGCCTCAATAA-------------------------T GGGGAATAATT------------------------------------------------- -------------------------------------------AGCCCCAGTCTAAACAC AACTCTGG---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------CCCTGCC--TAACAAATCTTAAAAGCAAGACCCA----------- ---------GAAGGATCAAACTG--------------------------------TTTCC AAG---------------------TAACTTAAATGCAACCCAGAACAAAGCTTA------ ------------AGAATGTTTACATAAATACAAAA------------------------- ------ATTTC---CAGTACCCAACAAGGTAAAATTCACAATG---------------TC TGG---------CATCCAATCAAAAATTAGCAGCAAGGAAAGAAGGAGG----------- -------------------------------------AAAATATAACCCATAAAAAAGGA GCAAAATCAATC------------------------------------------------ ------AATCAAACCATCCCAGAATT---------------------------------- ----------------------------------------------GACACAGATGTTGA ATTAGCAGACAAAGACATTAAAACAGT--------------------------------- ---------------------------------------------TTTTATAATTGTATT TCATGTGTT----------------------------CAAAAAGTGAAGTA--------- ------------GAGACATGGAAGATATATTTTAAAAAAGAACCAAATCAAACTTCTAAA AATAA----------AAACTTTA---------ATAT------------------------ ----------------------------------------------CCAAGATAAAAA-- ----ATCCCCTGGACGGGATTAGTAACAGATTAGCTATTGCA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAAGAAAATATTAGTC---------------------AAC T-----------AAAAGATATACTAATAGAAA---------------------------- ------------------------------------------------------------ --------------------------------GATCCAAAATGAAATACAGAGAGATATA GAATTAAAAATT------------------------------------------------ -----------AAAAAGACAAAGTATCAGTTAGCTGTGACACAA---------------- -----------CTTCAGTTGGCCTAATATACATGTAATTTG------------------- --AGTTCCTGAAGATGGGA----------------------------------------- ---GGGGGTGGAGAGAAAATA--------------------------------------- ---------------------------------CTAAAGGGGAA---------------- ------AAAACAGA-------GCAGAAAAACT-------GGAAACTCTAAAAATCAGAGC ACCTCTCCTCCTC-----CAA------------AGGAACGCACCTCCTCA---------- CCAG---CAATGGAACAAA-------GCT-GAATGGAGAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-CTTTGACG AGTT------GAGAGAGG------AAGGC------------TTCAGAAT----------- --AAACA---AAGTCTTAGGGAT----CTGTGGAAACT---------------------- ------------------------------CTAATTCAAGATTTATGAAAGAAGT----- ----------------------------------------T------------------- -------AAAAACCTTGAAAAAAAA---TTAGATGAATG--------------------- ----------------------GCTAA-------------CTAG------AATAACCAAT --------------------------------------GCAGAGAAGTCC---------- -----TTAAAGGACC--------------------------------------------- ------------------------TAAT-GGAGG---TGAAA---------ACCAC---- -GGCACGAGAA----CTATGTGATGAATGCA-------CAAG------------------ --------------------------------------------CCTCAGTAGCCAATG- -----CAATC--AACT------------------GGAAG---------AAAG-GCT-ATC AGTGATG----------------------------------------------------- ------------------------------------------------------------ ----GAAGACTAAATGAATGAAC-T--AACAGAG------TCCC---------AGAA--- ------------------GGAGAGAAGAAAG---AGA---ATAAAAAGAAA--------- CAA-ACAAAGCCTTCAA--GAACTAAATA-TATATGTA-----------AAA----TCTG AGTTCCTGAAGTTGGGAG-GTGTTACTGAAA--------------AAGATGGGGAGAATG GAACCAACTTGG---------AAAAAATACTAGT--T--------GAAATAATGGC-T-A AGAATTTTCCAAATTT--------------------GGCAAAAGACACAA--ACCTAAAT ATAC-----ATAAAAAACCTAAAAA---ACCACA-AAGAT-----AAAACA--------- ---A-CAAAAGAA-----ATGCTACCCAAA----------------------------GA CACATCATAATCAAACT------TTT-GAAAA---------CTAAAATTA---------- ------------AAA--AAAAAATCT---------------------------------- --------TAAAAACAGCCAGAGA---GAAAAAAC--------------ACATTAT---T TAT----------AGAG--------------GAACAACAAT--TAAAATGA-C--AGCAG ATT--------TCTCATCAGAA--ACCATA-GATG--CCAG-AAGAGAGTG--------- ----GAG-CAGAATA-T-------TTAAAA--T-ATT-GAAAGAAAAA------------ -AAT-----TTAAATCCCAAAA--------ATTAAT----------ATTCA--------- --TTAAAAAAAACC-----TTCG-TGAATGA-------AGG-TGAAATAAAAACATTCTC AGATAAAA-AAAAACTAAGAGA-ATTTATTACTAGCAGAC---CTGTTCTAA-AAGAACT CCT--------------AAAGGA----------------------AGTCC---------- ------------------------------------------------------------ ------------------------------------------------------------ -----------TCAACATGGAAAGGAACAACCGGTACCAGCCACTGCAAAAACATGCCAA ATTGA------------------------------------------------------- -----------TAAAAATTATACCGAATGGAAATATGGAACTACACAAAGGAATGAAGAA CACTGGAAATGGTAACTACA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TGGGTAAATACAAAATACTTTCTCTCATTA TTTAAATGTCTATAAAAGATAATTGACTTAAACAAAAATAGTGTAGTATGGTGGTTATAA CATAGGTACTAGTTA--------------------------------------------- ------------------------------------------------------------ -----------CCCATGAGAACTAGTGTGATATCACTTGAAG------------------ ----------------------------------ATAG-------------ACTGTGGTA AGTTAAAGATATATACTATAAACCCT---------------------------------- ----------------------------AAAGCAA-----------CCGCTAAAATAACC CA----------AAAATTATAGCTGATAGACCAACAAAAGAGATGAAATAGAATTATGAA ----AAATAATCAAAAAGAGACGCAAAAAAAGGA----AGAGAGTG------AACTAAGA ACAGATAGGACAAACGAAAAACAAACATCAAGATTATAATTTAGTCATAATTATATTAAA TATAAAGTCTAAACACCCAATTAAAAGGTAGAGATTGTCAAATTGGATAAATACA----- --------------------GAATCAA--ATAT-AAAAATAACAATAA------------ -------------TAAA-ATTAAATA-TAAATGGGCT--AAATAC---TTCAATTATAAA ACACAGAT--TGGCAAAA-TGGAT------------TAAAA---AGAACCCAACAA---- ---TGT-TTTGTTTAGAAGAA-ATTCATTT-CAAAT--GTAATGATATAGATAGGTTAAA AG--TAAAAGGA--TGGAAAA-ATATATACCATGCAAAAAT------TAATC-------- -------------AAAAA-AAAGCAG--GAGTGGCTATATTAATATC-AGATAAAATAGA TTTTAAA-GC----------AACGAAAATAAACAGAGAC-AAAA-AAGGACATTACAT-- ----AATAATAAA---AGGATCAATTCACC--AAAAAG--------AT-ATAACTATCAT AA-----------------ATATATATGTAACCAACAAAGGAGCA---AA--ATTCATTG AACCAAAAATAATAGAAATAAAAAGAGAAATAGACAAATATAC---------AATTATAG TTGGAGACTTCAACACCCTTT-----TCTCAACAATTGACAAA----------------- ----ATAACTAGAC------AGAA-----AATCAGCAAG---ATAAAAGAACTG------ --AAAAACACAATCAACCAACAAGAT-CTAATTG--ATATATATAGAA--TACTCCACCC AACAACAG---CAGAATACACATTCTTTTCA-------AATCCACAT---AAAACATTCA C------CAAGATAGACCATATCCTGGTCCATAAAATAAA-------------------- -CCTCAACAAATTTAAAAGAA--TTGAAAT----------------CATACAAA------ -GTATGTTCTCT---GACCACAATGGAA-TCAAACTAGAAATCAATAACA--------GA A-------------AG-ATAACAA---GAAAAACCTCAA----ACACTTGGAAATTAAAC AACACA-CTTCTAAA---TA-ATCCAAG--TGAAA---AAGGAAAAAT--CAA-AGGAAA TATTAAAATATACATT---GAAAT------------------------GAATGAAAATAA -AAATACAAC--ATATCAAAAAATG-TGG-GATACAGCTAAAGCAATGCTGAGAGGGAAA --TTTATAGCATTAAATGTTTTAATTAGAAAAG---AAAA--AAAATCT---AAAATCAA ------TAATCTAAATTCCCACCTAAA---GAAACTAAAAAA---AA---AAGAACAAAA TAAACCAA-AAGAAAGAA------------GAAGAAAGAAAATAAT-AAAAATAAAAACA AAAATA---AATGAAATTAAAAAAAAAAAAA-CAA---TAGAAAAAATC-AATGAAACAA -AAAGC-------TGGTTCTTTGAAAATATCAA--------------------------- -----------------------------------------------------------T AA-----AA------TTGATAAACCT---CTAGCAA------GACT-------------- GACAAAAAAAAAA---------AAGA-AGATACAAATTAC-------------------- -----TAATA---T---------CAGAAATGAAACA------GGAGA---TATCACTACA G--------ATCC-TGTAGACATT-AAAAGGATA--ATAAA---------AGAAT----- -------------------ACTACAAACAA-CTCTACACACATAA--AT---TTGACAAC TTAG---ATGAAAT--GGACCAATTCCT--T---AAAAAG---------CAC-----AAA CTACCA------AAACTCAACCAATATGAAATAGATAATCTGAAT--------------- --------AGCCCT------A------TAACCATTAAAGAAAT----TGAAT--TTATAA -TTAATAAAATACCTACAAAAAAAAATCTCCCAACTCC--AAAAGGTTTTCCAGGGAAAT TTTTA------------CAAAACTTTT----AAAAAAAAATAAACA-TAAATT------- ----TTAAAAACTTTTTCCAA-------GAAAATA-AAAGAGAGGA-----------AAT CTTTCCAAATTCTTTTATTAAA---------GCCAAAAA---TTTCCTGATAAC--AAAA A-----------------------AAAAA--AAAAAAA-CAAA----AA---------AA AAAAAAAAAT---------------------TAA------AAACAATAT--CTC----TC ATGAATATAGAT------------------------ACAAAAATCC-TCAA--------- ------CAAAATATTAGC-AAATAA------------------AA--------------- -----TAAAACA-------------ATATATA---------AAAAAATTTATACA----- ----TAAC------------CAAGTGGGATTTTTTCCCAGGAA-TGAAAG---------- -------------ACTGTTTA-AAT------TTTAA----AAAATAATCAATGTA--ATT CACCAT---------A------TCAACAA----GCTAAAGAAGAAAAAT---CATATGA- ----TCATATC---AATT----------AATGCAGA-AAAAG---CATTTGACAA---AA TTCAACACACATA-------------------TAAAA---------T-AAAAAC-TCTTA --GAAAAATAGGAATAGAAGGGAACT-----TTCTCAACTTGAT---------------- -----------AAAGAACAT-GTAC-AAAAAAATCACAGC-----------TAACAT--T ATACTTAATGGTGAAAA-A-----CTGAATTC-TTTT---CCCCTAAAAT----TAAGAA CAAAGAAAAGATGT-------CCACTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCATTCCTATTCAA-AATA--GTACT---AGAAG TAATTGCTAT--------TAAAATAAG------TAAAGAA---AAAAA--AATAAATAAA AAACAAATTGAAAAGAA----AGAAAAAATAAAA--TTGTTCCTA-----TTTACAGATG AC--ATGATGGTC-------TACATAAAAAATCTA---------------AAAAA---AT TAATAAAAAACATAAAAA--AAATAATAAAACT---------AATAAG--TGAGTTCAGC AAGG--TT-------------------------ACAGGATACAA--------------GA TCAACAT------------ACAAAAAT----CAATTACATTTC--TA-TATACTAA--CA ATGAACATATGGA------------------AACAAAAA-TTAAA----AATATAATACC ATTTACAATCAC-TCCAAA---AAAAATGAAATACTTAGGTATAAATTT--------AAC -AAAAAAAATTATGGAATTTTTATGTTATGAA--AATTACAAAATACTGATG-AAAGAAA TCAAAGA-----------AG------------------ACCT--AAAT--AAATGGAGAG ACAT------A---CCATGTTCATG------GAATAGAAGACTC-----AACA-TAGTA- ------------------------AAGATGTCAA-TT-CTCCCC-AA------------- ----ATTAATATATAGA---TTTAATACAATTCCTATCAAAAT---------CCCAGCA- AG------------ATTTTT---------------------------------------- --TGCAGATATAG---ACA------AACTTATTCTAAAA-TTTATATGGAA-------AG GCAAAGGAACTA---GA--ATAGCTAAAACAATCTTGAAAAAGAAAAATA---AAAT--A -------GGAGGAATCACT---CTACCTAATGTTAAGAC-----TTACTATAT---AGCT ACAGT-AATCAAAAC-AA------TGTTGTATGGG--TA-----------------GAGG GATAGACA------CATAGAT--CAATGGAACAGAATAAAGAACTT------AG--AAAT AGA---AAAAAAGATATTTAGTATACTAAATATAAACTTT---GACAAAAAAATAAATCA AAGAAAAAT------------AAAAAAGAAAAACAGT--------GTTTTTAAAAAAAAT AGTTCTG------------GAATAT--CTG---TAAATA---------------TATAT- AGAAAAAAAACAAAC--ATTGATTTAGATCTAA----CTTT---------------AAAA CT--TTATACAAAAA-TAAACA-CAAAATGGATCATAGACTTAAATGTA--AAACCTAAA ACCAAT------------------------AAAATTTTTAGAA----------------- -------AAA--AAATA------A---------GAG---------AAAATCTTTAGGAA- --CTA-----GG-CTTAGGCAAAGAATTCCTAACATT-AAAACCA-AAA----TCTTCAG CAATAAAAGAAAA-----------AC---TTAT--AAA-TTAGACCTC--ACCACAATTT AAAACTTTGTTCTGTGAAAGCACACTAAAGAAGATGACAAAAGACATAATATTCATAAAA ATAAAAAGCTT-TTTCA---ATAT-GAGAAAAACTAATAAA-ATAA-TAAAAGTCAAAA- ------AAAACCTAGTAAG--AAAATTGTC---ACAAGCTACATAT--------CTGACA AAGAACTGGTA-----TGTCAATAACATAAA--ACAAA--CTGAACATTTAAAAA----- ----------------------TCAAAAATAA---------AAC------------A--- AACGTCACGA-TTAAAA----------AATGGGCCAA-----------GGA--TATGAAC ---AGACATTTCACTGAAGAGGATATACAGA--------------TGACAAAT-AAGCAC ATGAAAAGATG----TTCAATATCATTAG-CCATTAGGAA-AAT--GCAAATT-AAAACC ACAATGAGA---------------------TATCACTACACACCTATTAGAATGGCTA-- ----AAATAAAAA---AAATAGAAA---------AAACAACAA--ATG--CTGGG-G--- ---------------ATGATGAGGAAAA-------------------------------- -----AGTTGATCACAT---ACATTTCTGG--TGGGAAATGGCTCTCTACTCAAAATGTT GGTAATCTCAAATTGTAGAAAAAA------AAATA-ATACAACC--------ACAATGT- -------AAAAAA-GTTTTTAAATATCT---------TTTAAAA--ATAAAACATATA-- -TTTAC-----------------ATTAGGCAATATATCACAGAAAGATG--AAAA----- ----------------------ATTCCATTCAC--ACAAAAATTTG----------T--- ---------ACAAA---ATTATTATTAGAACTTTATT---TATAATA-GCTAAAAAATTG AT--ATTT--ACAAAAAGTGCC--TCA---AATCAAG-----AATGGTTAAA--AAAAC- TG---------------------------------------------------------- --------------------TGGTACCTCC----ACAGCGTGTAACACTCAAATCA---- ATAACATTCTTGAAATGACAAAATTATAGAGATGGAGAACAGATTAGTGGTTGCCAGGGG TTAGGGATGGGGGG---------------------------------------------- -GGGAGGGGGTGGGTGTGG-C---TATAAAAGGGTAGCACGAGGGATCCTTGTGGTGATG GA-------------------------------------------------------ACA G-----------------------TTCTGTATCTTGACTGTGGTGGTGGTTACACGAATC TACACATGTGATAAAATTGCAT-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAACT---- -----------------------------ATACACACACACACA--------CAC----- ------ACACA---CAC------------------------AGATGAGTGCAAGTAAAAC T----------------------GGTGAA------------------------------- ------------------------------------ATCTG-------------AATA-- ------------------------------------------------------------ -AGATCTGTGGATTGTACCA---------ATGTCAATTTCCTGGTTGTGATATTGTACTA TAGTTATGCAAG------------------------------------------------ --ATGTTACCATTGGGGG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------CTGGGT--G AAGGGT-----------------------------------------------------A CAT-----------------------------------------------------GG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GACCTCCCTG-- ----------------------TACTATTTC----------------------TTGCA-- ------------------------------------------------------------ ------------------------------------------------------------ -----------ACTTCCTG----------------------------------------- -----------TGAATC-------------------------------TATAAT------ ------------------------------------------------------------ ------------------------------------------------------------ --------------TATTT------------CAAAATA--------AAAAGTTTATTAA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1ME2Z ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------A-------------------------- ------------------------------------------------------------ -------------------------------------TGAGGAA---------------- ------AAACAAGT-------GCAAAAATGCT-------GAAAATTCCAAAAACCAGAAT GCCTCTTTTCCTC-----CAA------------ATGAGTGCAACTCCTCT---------- CCAG---CAAGGGCACAAA-------ACT-GGACTGAGAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-GTTTGACA AATT------GACAGAAG------TAGGC------------TTCAGGAG---GTGAGT-A ATAACAA---ACTCCTCTGAGCT----AGAGGAGCATG---------------------- ------------------------------TTCTAACCCAATGC---AAGGAAGC----- ----------------------------------------T------------------- -------AAGAACCTTGATAAAAGG---TTACAGGAACT--------------------- ----------------------GCTAA-------------CTAG------AATAACCAGT --------------------------------------TTAGAGAAGAAC---------- -----ATGAATGAAC--------------------------------------------- ------------------------TGAT-GGAGC---TGAAA---------AACAC---- -AGCACGAGAA----CTTCATGAAGCATACA-------CAAG------------------ --------------------------------------------TATCAATAGCCAAAT- -----CAATC--AAAC------------------GAAAG---------AAAG-GAT-ATC AGAGATT----------------------------------------------------- ------------------------------------------------------------ ----GAAAATCAACTTAATGAAA-T--AAAGCA-------TGAA---------GCAA--- ------------------GATTAAAGAAAAAA--AGA---ATGAAAAGGAA--------- TGA-ACAAAGCCTCCAA--GAAATATGGG-ACTATGTG-----------AAAAG--ACCA AACCTATGAT-CGATTGG--TGTACCTGAAA--------------GTGATGGGGAGAATA AAACCAAGTTGG---------AAAATACACTTCA--G--------GATATTATTCA-G-G AGAACATCCCCAAACT--------------------AGCAAGACAGGCCA--ACATTCAA ATTC-----AGGAAATACAGAGAAC---ACCAAG-AAAAA--------ACA--------- ---A-CACAAAAA-----AAACAACACCAA----------------------------GA AACATAATCATCAGATT------CTC-CAAGG---------CTGAAATGA---------- ------------AGG--AAAGAATGT---------------------------------- --------TAAGGGCAGCCAGAGA---GAAAGGCC--------------AGGTTAC---C TAT----------AAAG--------------GGAAGCCCAT--CAGACTAA-C--AGTGG ATC--------TCTCTGTAGAA--ACCCTA-CAAG--CCAG-AAGAGAGTG--------- ----GGG-GCCAATA-T-------TCAACA--T-TCT-TAAAGAAAAA------------ -AAT-TT--TCA--ATGCAGAA--------TTTCAT----------ATCCG--------- --GCCAACCTAAGC-----TTCA-TAAGCAA-------AGG-AGAAATAAAATTCTTTAC AGACAAGC-AAGTGCTGAGGGATTTTTGTCACCACCAGGC---CTGCCTTAC--AAAGCT CCT--------------GAAGGA----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAAGAA-----------AAACCAGTACCAGC CACTGC------AAAAACATACC------A------------------------------ -------------------------AAATAA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAATG-AAAAT---------------------------- ----------------AG-TGCAT------------ATAAAA------------------ ---TTT-------TATATGAA--------------------------------GGCTGGA GT--AAGTATAA--TAGTTAA-AGAT--------AAAATAA------TGATC-------- -------------AAAAT---------------------------------TAGAAAATA CTTTGAACTG----------AATGATACTAAAAA------TAGT-AAAAGTGTTATAC-- ----AAT---------ATACTTAATTTAGA--AAAATG--------GGGGAAATTATT-T AATT---------------AAATGCTTACCTTGGAAAACTGAGGACTGAG---------- ----------------------------------------------------AATGATA- ----------TAATTTTGCA------TGTTAATA-------------------------- --------------------AGAT-----AAAAAAAAAAGA------------------- ---------------------------------------------GCA--CATTAAATCC AAAGTAAG---TAGAAGAAA------------------------------GGAA------ --------ATAATAAA----------GGTAACAGA--AAG-------------------- -CAACATTAAATATAAAGCAG---AGACAA----------------GAGAGGAA------ -ATA-----------------AATAAAA-TAAAAACAGAAAAAAATGTTA--------AC A-------------AA-ATCC-------AAAGTGT---G----ATAATTGATAATGTAAC AAT---------------------------AATTA---ATATAAACAT--AAA-CAGAAT AAATAAAA----------------------------------------CAATGAAAATAA -----------------ATAATATTAAGG-----------AAATAATTTTA----GCAAC --TTTATTCCATTA---------------------------------CT-------TTGA ------CAACTTAATT---------------GAA----------------AATAGAAAAC TAATTATA-TGCTTAAAA------------AAAAAGAGAGTTTTACCAAAAA-------- -AAATAACTGTTTAAATAAAAAT----AAAA-------------------GATGAAATGA ------------------TTTCAATAGAAAAAA--------------------------- -----------------------------------------------------------T AA-----AAATTGTCCTGAAAAACTT---TCCTATA------------------------ ----------------------GAGA-AAACTC--------------------------- -----CAGGC---T---------CACTGG---------------------TTTCACTATT GAATTCTATATTC-CATAAAA----AAAAAAATC--AAAAG------------------- -------------------CTCAGAAACAG-GTTTATACCGGTAA--AT---ATTAGAAT ATAG---ATGAAAT--ACAACCTTTCCT--T---GAAAAA---------TAC-----GTC CTTCAA------AAACCGAAGCAAGAAAGAA--AAAAATTTGATC--------------- --------ATACAC------A------AAATTATTTTAGAAAA----TGAAT--TTGTTA -TGAAAACCCTTTC---TATAAGAAC--TC-CAGGTGA--AGAGAGTATTCTCAACTCA- TTTTA---------------------T----AATCAAG---------CCAGCA-----T- ----AACTATAA-TATCTGAA-------AATAGAG-AAGAGGAG--------------AC ACTTTCCAACTCATTAGATAAG---------G---------------TAATACA--TAAA A-----------------------CAGTTGACAAAATAAAAAA----AA---------AA AAAAAAAATT---------------------ACA------GACCAATAT--CTT----TT ATGAATATAGAT------------------------GCAAAAATCC-TTAA--------- ------TAAAATATTAGC-AAATCACAATCATAAGAATAGGATAA--C------------ ---C-CA--ACACCAGAGCACCAAGATACATA---------AAATGGATATTAGA--TCA AAAGGGAGAGATAGGTATTCCAAAGTAGC-TTTCTCCGATGAATTGCAAG---------- -------------GCTGGTGC-AAA-----ATTGGT----TTAACATTCAAAATA--ATC AATCAA---------A------TTCACAG----TATTAATTTAATAAAC---AACAAGA- ----TAATATC---AATACACATAAATAGATGCAG--AAAAG---CATTTGACAA---AA TTCAACACAAATT-------------------TATGA---------T-AAAAAC-TCACC --ATAAAATAAGAATTAAAGGAACAT-----ACTTCAATTTGAT---------------- -----------AAAAGGCAT-CTAT-GAAAAACCTACAGC-----------TAACAT--C ATATTTAATGTTAAAAG-A-----CTGAAAGC-TTTC---CTCCTAAAAA----TTAGAA CAAGGCAAGGATAC-------CCAGTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTTCTATTCAC-CATT--ATAAT---GGAAA TTCTAACTAA--------TGTAAAAAG------ACAAGAA---AAAAA--AATAAAAATC ATTCCAAAAGATAA-------GAAAGAAAGCAAA--AATACTTTA-----TTTACAGAAA AT--ATAATTGTT-------TTTTTAGAAAATCCA---------------AAATTAATCA TCACAACATTTAAACAAA--AAAACATAAAAATAATAAAAAAAATAAG--TGGATTTAGC AAGG--TC-------------------------TCAGGATACAA--------------AA TTGAAAT------------ATAAAAAT----CACATTTATATT--TA-TATATTAA--CA GTAAAAAATTAAA------------------AAATAAAA-TTATTTTTAAATTTAAT--- -TTTAAAATCGC-TAAAAAGATAAAAATTAAATAAATAGGAATAAAAAT--------AAC -AAAAGATATGAAACAACTAT---ACAAAAAA--AACTATAAAACAATATTA-AAAAAAA TTAAAAA-----------AA------------------ATAA--AAAG--AAATGTAAAA TTTT------T---ACATGTTTATT------GATTGGAAGACTC-----AATA-TTGTT- ------------------------AAAATATCAATTGTCTTCCCCAA------------- ----ATTGATGTATAGA---TTCAATAGAATTTCCATTAAAAA---------TCCAATA- AG------------AATTTT---------------------------------------- --AAATGAAGTTGATTATA------AACTACATATAAAAATTTATATGGAA-------TG AAAAAGGACCAA---GA--ATATCCAAAGTGGACATCAAAAAAAAGAATATCCGATC--T -------TGAGGAATTATG-----ACTTTATAGTAAAAACAGTAATCAAACAA---GATT TCAAA-AGTGAAAAC-AT------TAAAATAATTA--TA-----------------AAAA AAAAAGAA------AATCAAG--AAATTAGAAGTGATAGAATTGTT------GG--AAAT TAA---TTTTTAAATATGAA----ATTTAA---GATTTTT---AAAAAA--AAAAG--TA AGGATATCC--AGCAA-----AGAAAAG----ATATC--------GCGTTTTTAACAAAT GAATCCC----------A----ACCCCTGA------------------------TATGT- ATA---------AAT--ATGA----GAAACCTG----TTCT-----------AAAAAACA TT--ATAGAAAAAAA-TTAATT-ATAGATGGATCATGGACATAAAAGTA--AAACCAAAA AAC-AT------------------------AATGTTTTTAAAA----------------- ------GAAA--ACATT------G---------AAG---------AATATCTTTGTGAC- --TTT-----GG-GTTAAGCAAAGATTTTTTAGATATAAA----A-AAA----ACAAATC ACAGAAAAATAA-----A------AT---TGAT--CAA-TTACATTAT--AT-------- -------------------------------------------------------C-AAA AATAAAAACTA---ATA---CATT-TAAAATTACACTTATT-AATA-TAAAAAA-GACAT TTGTTAAGCCAAT-GCCAGATGACAAACTA---GCAAAAAACATAT--------GTAACA CAGG-------------------AATGTGAG--AAAAATTCCTAACCATAATAAA----- ----------------------GCGAC-ATAGGACATATAATAA------------AATT ATAATTCCTA-TAAAGAACAACAATATAATTGGCAAA-----------AGT--CTAGAAG ---AGGTGAAATTAAAAGGCAGATACGTAAAAAAATTTGAAAAAGTAACCATT-A-GCAT ACTAAAAAGTG----CTCAAAAACACTGAGTTATCAGGGA-AAT--TCAAAGT-AAAATC ACAGT---A---------------------AACAACCATACAACTACAAGAATAACTGAC A---TAATAAAAA---AAATTAAT------------ACACTAA--ATG--TTGGT-G--- ---------------AGGATGTGGAGCA-------------------------------- -----AATAGAATTCTTAC-ATATTTCTGG--TAGGAG---------------------- -------------TGTA-------------AACTG-GTAAAATA--------ACTTTGA- -------AAAATG-AT-TGGGACAGTTC----------TTAAAT--ATAAACCAA----- -TTTGA--TCTAGCAATTGTACTCCTAGG-TATTTATCACAAAATAAAT--GAAA----- -------------------AATATGAC--------AAAACAATTTG----------T--- ---------AAATG--AATGGTCATAACACCTTTATT---CACAATGCACAAAAACAA-G CA--AATA-----CAAA-------------AGAGCTC-----AATGAATAAA--GAAAT- TA---------------------------------------------------------- --AAGG--------------TAATATATTTATTCATACAATGAACAACCATATGAA-GTT CTAGAACAGGCAAAACTAATACATGGTGAAAAATAAAATTAGAACATTGTTTGCCTTTGG GGGGTGGGGCAG------------------------------------------------ -GGATTGACTGGGAAAGGG-C---A----------------GGAGACAACTTTCTGGGGT GATGGTAATGTTCTATATCTTGATAAGGGTTTGGGTTACGCAGGTGTATGCATTTGTCAA A----------------------------------------------------------- ----------ACTCA--GTGAA-------------------------------------- ------------------------------------------------------------ --------------------------------------------------TGTACA---- -----------------------------CTTAATATTTGTATA---------TT----- ------TCACTGTATGT------------------------AAATTTATAT---CTAAAC AAAAAAAAAACTATAAAACAAATATTGAACTCTAGTTAATGATAT--------------- ------------------------------------GCATGCT-----------GAAA-- -------TG------------------------------------------TTTAGG--- -AGAAAAGTG-----TACTG-----ATGTCTGTAACTAACTTTGAAATGCACCAAAACAT AAGATGGATTGA------------------------------------------------ --TGG-----ATGGATAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGG--------GATGAATAGATGGATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GATATGT---------------------------------------------- --------GATA-------------------------------------AATCAAATATA GTAAAA------------------------------------TGTTAATGGT-------A GAA-----------------------------------------------------TCTA GGTGGTGGGT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGGTATATGG-- -------------------A-----TGTTCA--------CTGTAAAATTCTTTCAACT-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ATGG-TGTGTG-------------------------------TGTGAA------ ------------------------------------------------------------ ------------------------------------------------------------ --------------AATTT------------TTATAAT----AAAATGTTG------GA- -------AAAAAA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MD3 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GAA------------CTTAAGAT----------C ATAAGAA----------------------------------------------------- -------------------------------------------------ATAAAT----- ----------------------------------------T------------------- ------------------------------------------------------------ --------------------------------------------------AATGGAAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TGCT-GGAAA---TAAAA---------GACAC---- -ATTTAGAGAA----ATGCAAAACACATTGA-------AAAG------------------ --------------------------------------------TATCAAAAATAGAAT- -----CGAAC--AAGC------------------AGAAA---------AAAA-AGC-TTC AGAGCTC----------------------------------------------------- ------------------------------------------------------------ ----AAAGACAAAGCCTTTGAAT-T--AACCCAA------TCCA---------ACAA--- ------------------AGACAAAGAAAAA---AGA---ATTTTAAAAA---------- TGA-ACAAAGCCTCCAA--GAAATGTGGG-ATTATGTT-----------AAATAG-ACCA AACCTAAGAG-TAATTGG--TGTTCTTGAGG-----------------AAGAAGAGCAAT CTAAAAGTATG----------CAAACTTATTTGAAAG--------GTAATAATCGAGTAA AAAACTTCCCTGGTCT--------------------TGCTAGAGATCTAAAGACATCCAA ATAT-----AAGAAACTCAAAGAAC---ACCTGA-GAAAT--------TCA--------- ---T-CACAAAAA-----CATAATAACCTA----------------------------AC CACAAAGTCAGCAGATA------ATCTTTAAG---------TCAAAACGA---------- ------------AGG--AAAACATCT---------------------------------- --------TAGGAGCTGTGAATCA---AAAGCATC--------------GGGTATC---C TAT----------AAAA--------------GAAAACCTAT--CAGATTAA-C--AGCAG ATT--------TCTCAGCAGAA--ACCATG-CAAG--TCAG-GAAGCATTG--------- ----GAA-CA----------------------T-TAT----------------------- ---------CCA--GCCAAGAA--------TTCTGT----------ATCCA--------- --GCAAAACTAAGC-----TTCA-TAAATGA-------AGG-AGAGATAAAGCCTTTTTC AGACAAAC-AACTGCTGAGAGA-ATTCACAACTACCAAGC---CAACACTAC-AAGAACT GCT--------------AAAAGG----------------------AGTCC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATTG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AAAAG ------------------------------------------------------------ -------CCTGTTT---------------------------------------------- ------------------------------------------------------------ ------------------------AGCAGAATAAGCATTCT------------------- TTTCAAG----------------------------------------------------- ------------------------------------------------------------ --------------------------TGCAC---------------------ATGAATAG AATA-------------------------------------------------------- ------------------------------------------------------------ --------GAAGAC------AGAA-----AAACAATAGAGAAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------ATCGACCATATCCTGGGTCATAAACAAAG-------------------- -TAAAAACAAATTTAAAAGAA--CTGAAAT----------------CATACAAA------ -GTCGGTTCTTT---GAACAT----------AAACTAAAAATCAATAAAC--------AG A-------------TA----ACAG---GAAAATCTCCAA----ACACTTGGAAAATTGAT AAAACA-CTTCTAAA---TA-ATTCATG--GCTTC---TAGGAAGACT--GAC-AAAGAA AAAAACAAAATACTTT---GAACT------------------------GAATGAAAATAA -AA---------ATATCAAAACGTA-TGG-AATGCAGCTAAACCAGTGCTTAGAGACAAA --TTTTCAATATCAGACGGC--------------------------TTT---TAAA---- --------------------------------------------------AAGAGCAAAA TAAAT-GA-AAGCAAGCA------------GAAGGAAAAAAGGGGCGAAAAATCAATG-- AAAATA---AGGGATATCACTAT-------A-------GATGGAAAATC-AACGAAACCT -ACAAC-------TAGTTCTTTGAG-----CAA--------------------------- -----------------------------------------------------------T AA-----AA------TTGATAAACCTCTCCTAGCGA------GATT-------------- ------------------------GA---------------------------------- -----CAATC---T---------TAGGAATGAAAGA------GA------TACCACTACG G--------ACCCTCATT-------AAAAGGATA--ATAAG---------AAAAT----- -------------------ACTATGAACAA-TTCAATGCATAGAA--AT---TTGACAAC TTAG---ATGAAAT--GGACAAATTCCT--T---GAAAAC---------CAA-----GAA CTACCA------AAACTTAAGC------TAATAGATAACCTGAAT--------------- --------AGCTCT-------------TATTTGTTTAAAAAAT----TGAATTCTTGT-- -TTAAAAAATTTGTGACAAAGAAATC--TC-CAGGCCCCTAAATGG-TTCACTGGTGAA- GTCTA------------CCAAACATTT----AAAGAAGAAATAATA-CCAATT-----C- ----TACAACATCTCCTCCAG-------AAAATAG-AAGAACAGGG-----------AAC ACTTCCCAACTCATTTTATGAG---------GCCAGCAGAATTACCCTGATACC--AAAA C-----------------------CAGAC--AAAGAAAGTAAA----AG---------GA AAAGAGAACTACCTCAGAAACACGCGTGCAAACA------AACC-ATAT--TCC----AC ATGATCATAGAT------------------------ACAAAAATTC-TCAA--------- ------TAAAATATTAGC-AAATCA------------------AA--T------------ ---C-TA--TCA-------------AGATATG---------AATAA---CATACA--AAT ----TTAC------------AAAGTGGGG-TTTATTGTGGGAT-TGCAAG---------- -------------GCTGGTTC-AAT-----ATTAGA----AAATCAATCAATGTA--ATC CACCAT---------A------TTAATAGTCTAAAGAAAAAAAAAAAAA---CAAACGAC GAATTGATATC---TATA----------GATGCACAGAAAAA---AATTTTCCAA---AA TTTAACTTCCATT-------------------CATGA---------T-AAAAAT-TCTCT --GCAAACTAGGAATAGAAGGGAACT-----TCCTCAACCTGAT---------------- -----------AAAGGCCAT-CTAA-AGAATACCTACAGCAAACCTATATTTAATAC--A GTGCTTAATGGTGAAAG-A-----CTGAATGC-TTTCGAATCCCTAAGAT----CGGGAA CAAAACAAGGATGT-------CCGCTTT-------------------------------- ------------------------------------------------------------ ------------------------CAACACTTCTATTCTAACACATTGTACT---AGAAA TTCCATCCAC--------TAGAATAAAA-----GCAACA----AGAGA--AGTATGATAT ATCGAAACAAATAA-------AAAACAAGAAAAA---CATGATTA-----TCTACGTAGA A-----AATCCCAAGGAAATTACATTGAAAATCCA---------------AAGGA---AT CTACAA---------AAA--ATCTCCTAGAAAT---------AATAAG--TGAATTTA-C AAGG--TT-------------------------GCAGGATACAA--------------GA TCAACAT------------ACAAAAAT----CAATTACATTTC--TA-TATACTAAAGCA ACGTGCAATCGGA------------------AACCGAAATTTAAAAATTAAAAAAATTAA ATTTACAATAGT-TCCCAA---AAATATGAAATACTTAGGTATAAATCT--------AAC -AAAAGATGTCCAGGTTCTAT---ATGCCGAA--AACTGCGATTACCTGATGTTAAGAAA TCAAAGA-----------AG------------------ACCT--AAA---AAATTGAGAG ATA-----------CCGTGTTCATG------AATCAGAAGAGTC-----AACG-A-GTA- ------------------------AAGATGTCGA-TT-CTCCCC-AA------------- ----TTTGATCAATAGA---TTTAATGCAATTCCAATCAAAAT---------CCCAGCAG GA------------TTTTTT---------------------------------------- --TGTGGATATAG---ACA------AGCTGATTCTAAAG-TTTATATGGAA-------AG GCAAAGGAACAT---TAGAATAGCCAAAATAATTTTGAAAAAGCAGAATA---AACT--T -------GGAGGAATCACAGTGCTACCTGATTTTAAGAC-----TTACTATAA---AGCT ACAAT-AATCAAGAC-AG------TGTGGTATTGG--CG-----------------AAGG GATAGACAATTATCAATAGAT--CAATGGAACAGAATAGAGAGTCC------AG--AAAT AGA---CCCACACAAATATA----GGCAAA--TGATTTTT---GACAAA--GGTGC--AA AAACAATTC--AATGGAATAAAGGAAGG----ATAGC--------CTTTTTACAGCAAAT GGTGTTG----------G-AACAAT--TGG-A-CATCCA---------------TATGC- AAA---------AAATGATTGACCTAAACCTCA----CTCCACCTAAATTTTATAGCTTA CC--ATATAAAAATA-TTAACT-CAAAATGAATCATAGATCTCAAAGTA--AAATATAAA ACT-AT------------------------AAAACTTTTAAAA----------------- ------GAAA--ACATA------GGAACTTTTAGAAAAAAATGGGAAAATCTTCATGAT- --CTG-----GGAATTAGGCAAAAAGTTCTTAGACAT-GACACCA-AAA----ATATAAT CCATCAAAAAAATGAAAA------AT---TGAT--AAA-TTGGACTTC--AT-------- -------------------------------------------------------C-AAA TTATAAACTTCGTTGCT---CTCC-------CACTGTTAAG-AAAA-TGAAAAG-ACACA CTGC--ATGC--T-GGGAG--AAGATATTT---GCAAAGCACATAT--------CTGATA AGGGATTAG-------TATCAAGAATAAATA--AAGAA--CTCTC-----AAAAC----- ----------------------TGAATAATAA------GAAAAC------------AG-- ATCAACCTAA-ATTAAA----------AATGGGCAAA-----------AGAACTTTGAAA ---AAACATTTCACCAAAGAAGATATACAGA--------------AGGCAAAT-AAGCAC ATGAAAAGACGTCGATTCAACATCA-TAG-TTATGAGGGA-AAT--GCAAATT-AAAACC ACAATGAGA---------------------TA-CACTGCACATCCTCTAGAATGGCTA-- ----ATTTTTAAA---AGTCTGACA-----------ATACTAA--GTG--CTGAT-G--- ---------------AGCATGCGGAGCA-------------------------------- -----ACTGAAACTCGCAT-ACATTGCTGG--TAGAAA---------------------- -------------TGCAAACAA--------TGTAG-ATATAGCC--------ACTCTGG- -------AAAACA-ATTCGGCA--GTTT-TTTAAAAGATTAAACATCCACACCTACCAAT GTATAA--CGTAGAAATTCCACTCTTGAT-TATTTA-CCTTAATGAGAA--TGTA----- -------------------AACATATG-TTCAC--ACGAAAACCTG----------T--- ---------ACGTG--ATTGTTTACGGCAGCTCTATT---CGTAATACGTCCAAAACT-G TA--AAAA--ACCCAAATTGTCCTTCATTCACGGGTG-----AATGGATAAA--CAAAC- TG---------------------------------------------------------- --AGTGAGACAGCCATACAATGGTATATCC----GTACAATGGAACAA--TACTCA-GCA ATAAAA----------------------AAGAATGAAGTACTGATACAT----------- ------------------------------------------------------------ -GCTAGAACATGGATGAAC-C---T----------------CAAAATAATTACGTTGAGT GA-------------------------------------------------------AAG A----------------------------------------------------------- ----------AGCCA--GG----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------TA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---AAT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1ME1 TTTAAAAAAAAAAAATAAAGAAAAAATTTTACATTTAAGATA--AAAAAAT-AAGGCTTG ATATTTACCAT------CCTTC--------ATGAAACAAATT------------------ ---------------------ATAA---------AAATTTCTAAAAATA--------TAT AA--TTTTAA----G-----TAAGTTAGAATAGAGTCAATCAAA-----------TTTGT TAAA---ATAGAAAG--ATAGAAAACAGATTATGT--------------GACCCCAGTGA TTGCCCCTCTTTACTGTCTGAATATAGGAAACAGATCACTTTGAAA-------------- ------------AAAGAACCG-----------------AG--AAAGCAGCGATAAGCTT- ----------------------------TC----TTAAG-----ATG-----AG-AGGAA GAAGAATGGATTGTTG------AATAAGGATGGTG--GCTTTAT-TTGGCGGGCCATTTT C-------------------------------AGGATATAGGTTAACATA---------- GAGGAAGCACGGCGAACT---GCG------------------------------------ ---GTTTGCTTGTGTCTAGGAGCCAGTACTGG------------------TGAGTTCATG CAGGCAAAGGAACTATTCTTA---------TAGAGGAGAATGAAAAGGTAGGAGGA---- ------------------------------------------------------------ --------------------------------------------AAACCAGAAAAGATCT GCAGGGGATGAGG----------------------------------------------- ---------TGGCA-CCCTCTGAGTGTTTGGCTGAATGCTATTCCA-------------- ---AGAATTCAAGAGAGGGACC-------------------------------------- ------------------------------------------------------------ --------------------TTCGTGAGGTTATGGTA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AAAA--------------GTGCTGAAAAACAG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------TTATTTTACAAA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------AATTGGCAACAAAAGAGCA---- ---------GAA----TGCAGAA--------------AGAGTTTTAGAAATCACTCCAAC CAA--------------------------------------------------------- --------------------------------------------------------GCAG ACAAATCATCT---TGGAAATAA-----TT-----AGAACCCA---------------AC AGAGTAG----------------------------------------------------- ------------------------------------------------------------ -----GTTAAAGTTCTCCCGATGCATATGG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------CAACA ATTTGT------------------------------------------------------ -------------------------------------------GACAAATA--------- ------------TGCACGGAAGG------------------------CATATCCATTTAT GTGAA-------------TCCAA----------TAT------------------------ -------------------------------------------GTCCCAGTCACTGAAAC T---CAATTAT------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AAAGCAAAATA--------------------------AAT T-----------ACAAGACAATGCATACTAGATATCGT---------------------- ------------------------------------------------------------ -----AAATCATAGTTTAAAGCAG------ATCGATTCATAATGAATGCAAACG------ ------------------------------------------------------------ -----------TAAAAGTC----------------------------------------- ------------------------------------------------------------ --AGCATCAG-ACATTAAA--------------A-------------------------- ---AAATCAACGGAACTGGCT--------------------------------------- ------------------------TCAAGTAGAGAAATGTGAGA---------------- ------GAATAAAAATATA--------------------CGGAATTTAAAGAAGCTACGT CATATTTTAAATT-----AAAGGAGGTGAAAACAAGGTTATAATTATTAA---------- AAAAAAGGAAAAAGTTTTC-------AAA-ATTGTAAAAT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-TAT---TA CAAT------ATTAGAAA------TGAGA------------ATTACAAT---ATCTGA-A ATAAAGAATGAACCGGATGCGATTAATTGCAAATCATA---------------------- --------------------------CTCTGCTGGAGATAGTAT---TAGAAAAG----- ----------------------------------------T------------------- -------AAAAGGTCAAAAAAAACG---CAAGAGAAACT--------------------- ----------------------TCCAG-------------AGCA------AAAAG----- ----------------------------------------AAGAAAAAAT---------T TATAGTTAAAAAAAC--------------------------------------------- ------------------------TTCT-AGAGA---TAAAA---------CCTAC---- -AATATGTGAG----ATGAAAAATACACTGG-------ATGA------------------ --------------------------------------------GATTAATAACAGATT- -----AGACC--TTGG------------------AGAAA---------AAAG-AAT-AAA TAAACTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACATAGCAATAGAAA-T--AATCCAA-------------------ACCA--- ------------------AAATAAAGAAGAA---AAA---AAAAAAAAAAA--------- --A-AGATAACATCAAG--GACCTGTGGG-ACAATGTC-----------AAGCG--GTTT AATATATGTG-TAATTGG--AGTCCCAGAAG--------------CAGAAGGAGAGGGAG AAGAAG---------------AAAAAAAATTTGT--A--------AAAAAAATAGC-TCA AAAATTTCCCAAATTT--------------------AATGAAAAACATAA--ACCAACAG ATTC-----AAGAAGTTCACTAAAC---CCCAAA-CAGAA--------AAA--------- -----CATAAACA-----AAACCACACCAA----------------------------GA CACATCATAATCAAATT------GCT-CAAAA---------CCAGAGATA---------- ------------AAG--AAAAAATCT---------------------------------- --------TAAAAGCAGCCAGAGA---AAAAAAAC--------------ACATTAG---T TAT----------AAGGATACATTATATAGAAGAAATCAAAATTTTAATGA-T--AGAAA AT---------TTTCATTAGAA--AAAAAT-GGAG--CCCA-AAAAGAATG--------- ----GAA---AAACA-T-------TGTAAAAAT-ATT-GAAAAAAAAA------------ -AACCTTAGTCA--ACCCAGAA--------TTCTAT----------ACCCA--------- --GTAAAAATATCC-----TTCA-AAAATGA-------AGG-TAAAATAAAGACATTTTC AGATAAAC-GAAAGCTAAGAGA-ATTCATTACCAGCAGAC---CTGCACTAA-AAGAAAT TCT--------------AAAGGA----------------------AGTTCTTCAGAGAGA A----------------------------------------------------------- ---------------------------GGAAAAGATAAAATTGTAAAAAAGTAATAAATT CTTAACCTTCCAAGTATAAAGAAAAAGAATAGAGTAACAAGCCACATGAAAAAAGATAGA AGGATGTTTACAAAATAAC--------------------AAAGAACAAGTATCAAAAAGG AAA-------GTAATT----------------------ACTGATTTTTTCTTATAAAGAA AACGAAGAACTTGGTTCTTTGCATACTTTTT------CGAAAAGAAATATT--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CAAAGAAGATTTTCAGAAAGA AGGAAAATGATAGCATAGGGAAATTTTGAACTTTACAAATAAATGAAGAGCAATAGGAAT GGTAAAAGTTTTGGTG---------TTTGAAAAAGAAAATTATATGAAAAGTTTTTTGGG CTTATATGACGTAGAGATGTAGAACATAATGAGACTAGTACAAATGACATGGGGAGGGGA ATGGTAGTATATTCAATTTTGAAGGTTATTTTCTAGGTAACATTATATTAAGAATAAAAT CTGAAATGTATTAAAGAAAGAAAATAAAATAGGAAAAGAAAATCAGAAAGTAACAATAAT ATTATATCTTATTGATGAGAAGTGGTAAAATAGTAATTGA-------------------- --AAGTAGATTG------TGATAAA---------TTAAAGATACATATTGT--------- -------------------AAACCCTAAAGCAATCACGAAA---------ACAATAAAAA AGAGATATAGGC---CAAATAATCAATAAAGGAAG-----------TAAACAAGGAATCC ------------AAAAATATACT------CT--------------TAAC-----CACAAT ----AA--GAACAGGACGGAAAA--GAAGGA-------AGAAAA--G-----AAAAAAAA AAAGAAGAGAAAAAAAGAAAACAAATAGC-------------------------AAG--- --------------------------------------------------TAACA----- --------------------GATATCA--ATAA-AAATATAAAAATAA------------ -------------TTAT-AATAAATG-AAAATGATTT--AAACAC---TCCAATTAAAAG GCAAAATC--TACAAAAT-TGGAT------------AAAAAAGCAAAAACAAAATA---- ---TAT-GCTCTCTAAAAGAA-ACCTACTT-TAAAT--ATAAAGATACAAATAAGTTAAA AG--TAAAAGGA--TGGAAAA-AGATATACCATGCAAACAC------TAATC-------- -------------AAAAG-AAAGCTG--GAGTGGCTATATTAATATC-AGATAAAGTAGA TTTCAAA-GC----------AAAGAATATTACTAGAGAT-AAAG-AGGGACATTTCAT-- ----AATGATAAA---AAGGTCAATTCATC--AAGAAG--------AC-ATAACAATTCT AA-----------------ATGTTTATGCACCTAATAACAGAGCTTCAAA--ATACATGA AGCAAAAAACTACAAAAATAAAAAGAGAAATAGACAAATCCAC---------AATTATAG TTAGAGATTTCAATACTCCTC-----TCTCAGTAATTGATAGA----------------- ----ACAAGTAGAC------AAAA-----AATCAGTAAGGATATAGAAGAATTG------ --AACAACACTATCAACCAACTTGAC-CTAATTG--ACATTTATAGAA--CACTCCACCC AACAACAG---CAGAATACACATTCTTTTCA-------AGTACACAT---GGAACATTCA C------CAAGATAGACCATATTCTGGGCCATAAAACAAA-------------------- -TCTCA---------AACAAA--------------------------------------- -GTATGTTCTCT---GACCATAATGGAA-TTAAAATAGAAATCAATAACA--------GA A-------------AG-ATATCTG---GAAAATCCCCAA----ATATTTGGAAATTAAAC AACACA-CTTCTAAA---TA-ACCCATA--GTTAA---AAAAAAAAAT--TAA-AAGAAA AATTAAAAAATATTTT---GAACT------------------------GAATGAAAATAA -AAACACAAC--ATATCAAAATT---TGG-----CAGCTAAAGCAGTATTTAGAGGAAAA --TTTATAGCATTAAATGCTTATATTAGAAAAG---AAGA--AAGGTCT---CAAATCAA ------TAACCTAAGCTTCTACCTTAA---GAAACTAGAAAA---AA---AAGAACAAAT TAAACCCA-AAGTAAGCA------------GAAAAAAGGAAATAAT-AAAGATAAAAGCA GAAATC---AATGAAATAGAAAACAGAAAAA-CAA---TAGAAAAAATA-AATAAAACAA -AAAGT-------TGTTTTTTTGAAAAAATCAA--------------------------- -----------------------------------------------------------T AA-----AA------TTGATAAACCT---CTAGCCA------GACT-------------- GATCAAAAAAAAAAAAAGA---GAAA-AAACACAAATTAC-------------------- -----CAATA---T---------CAGGAATGAAAGA------GGAGA---CATCACTACA G--------ATTC-TACAGATATT-AAAAGGATA--ATAAG---------GAAAT----- -------------------ATTATGAACAA-CTTTATGCCAATAA--AT---TCAACAAC TTAG---ATGAAAT--GGACAAATTCCT--T---GAAAGA---------CAC-----AAA CTACCA------AAGCTCACTCAAGAAGAAATAGATAACCTGAAT--------------- --------AGCCCT------A------TAACTATTAAAGAAAT----TGAAT--TTATAG -TTAAAAATTTTCCCACAAAGAAAAC--TC-CAGGCCC--AGATGGCTTCACTGGTGAA- TTCTA------------CCAAACATTT----AAGGAAGAAATAATA-CCAATT-----C- ----TACACAAACTCTTCCAG-------AAAATTG-AAGAGGAGGA-----------AAT ATTTCCCAACTCATTTTATGAG---------GCCAGCAT---TACCCTGATACC--AAAA C-----------------------CAGAC--AAAGAAA-TTAC----------------A AAAGAAAACT---------------------ACA------GAACAATAT--TCC----TC ATGAACATAGAA------------------------ACAAAAATTC-TTAA--------- ------CAAAATTTTTACAAAATTA------------------AA--T------------ ---C-CAATACA-------------ATATATA---------AAAAAGATAATATA--TCA ----TGAC------------CAAGTGGGT-TTTATCCCAGGAA-TGCAAG---------- -------------GTTGGTTT-AAC-----ATTTGA----AAAAAAATTAATGTA--ATT CACCAT---------A------TTAACAA----AATAAAAAAGAAAAAC---CATATGA- ----TCATCTC---AATA----------GATGCAAA-AAAAG---CATTTGACAA---AA TCCAACATCCATT-------------------CATGA---------T-AAAAAC-TCTCA --GCAAACTAGGAATAGAAGGGAACT-----TCCTCAACCTGAT---------------- -----------AAAGGGCAT-CTAC-AAAAAACCTACAGC-----------TAACAT--C ATACTTAATGGTGAAAG-A-----CTGAATGC-TTTC---CCCCTTAAGA----TAGGAA AAAAGCCAAGAATT-------TCACTCC-------------------------------- ------------------------------------------------------------ ------------------------TAACAATTTTATTCAACCATT--TTATT----GAAG TTCTAACCAA--------TGCAATAAA------GCAAGAA---AAAGA--AATAAAAGGC ATACAGATTGGAAA-------GGAAGAAATAAAA--CTGTCTTTA-----TTTACAGATG AC--ATGATTGTC-------TATATAGAAAATCCA---------------AAGAA---AT CTATAA---------AAA--AAATACTAATACT---------AATAAG--TGAGTTTAGC AAGG--TT-------------------------GCAGGATACAA--------------GA TCAATAT------------ACAAAAAT----CAATTTTATTTT------ATACTAT--AA AAAAAAAATTAGA------------------AATTAAAA-TAATA----AAAA------- --TTAAAATAAC-ATCAAA---AAATATGAAATACTTAGGGATAAATCT--------TAC -AAAAAATATGCAAAATATTTTATATATTAAA--AACTATAAAATATTGCTG-AGAGAAA TTAAAGA-----------AG------------------ACCT--AAAT--AAATGGAGAG ATAT------A---CCATGTTCATG------GATTAGAAGACTC-----AATA-TTGTT- ------------------------AAGATGTCAA-TT-CTCCCC-AA------------- ----ATTGATCTATAGA---TTCAATGCAATCCCAATCAAAAT---------CCCAGCA- GG------------CTTTTT---------------------------------------- --TGTAGAAATTG---ACA------AGCTGATTCTAAAA-TTTATATGGAA-------AT GCAAAGGACCTA---GA--ATAGCCAAAACAATTTTGAAAAAGAAAAACA---AAAT--T -------GGAGGACTAACA---CTATCTGATTTCAAGAC-----TTATTATAA---AGCT ACAGT-AATCAAGAC-AG------TGTGGTATTGG--AA-----------------TAAA GATAGACA------AATAG----CAATAGAAAATAGAAGAGAGTCC------AGAAAAAT ACA---CACACATATATATA----AAAAAG--TGTTTTTG---AAAAAA----------- ----------------------AAAAAA----TTAAT--------TTTTT--CAACAAAT GATGCTG----------G-AACAAT--TGG-A-AATAAA---------------AATAAA AAAAAAATAAACAAA--ATGAATTTTAATCCAT----ACCT---------------TACA CC--ATATACAAAAA-TTAACT-CAAAATGGATCATAGACCTAAATGTA--AAACCTAAA ACT-AT------------------------AAAACTTCTAGAA----------------- ------GAAA--ACATA------G---------GAG---------AAAATCTTTGTGAC- --CTT-----GG-GTTAGGCAAAGAATTCTTAGATAA-AACACCA-AAA----ACAATAA TCCTAAAAAAAAAAATTA------AT----GAT--AAA-TTAAACTTC--AT-------- -------------------------------------------------------C-AAA ATTAAAAATTT-TTCTT---T----AAAAGACACTATTAAA-AAAA-TGAAAAG-ACAAG CCAC--AGAC--T-GGGAG--AAAATATTT---GCAAATCATATAT--------CTGATA AAGGATTTA-------TATCCAGAATATATA--AAGAA--CATAC-----AAAAA----- ----------------------TC------------------------------------ AACAACTCAA-TAAAAA----------AAATGGCAAA-----------AAA--TTTTAAA ---AAACACTTCACCAAAGAAGATATATGGA--------------TGGCAAAT-AAGCAC ATGAAAAGATG----CTCAACATCATTAG-TCATTAGGAA-AAT--GCAAATT-AAAACC ACAATGAGA---------------------TACCACTACACACCTATTAGAATGACTA-- ----AAATAAAAA---AAACTGACA-----------ATACCAAGTGTG--GTGGT-G--- ---------------AAGATGTGGAGAA-------------------------------- -----ACTGGAACTCTCAT-ACATTGCTGG--TGGGAA---------------------- -------------TGTAA------------AATGG-TTACACCC--------CTTTTGA- -------AAAACA-TTTTGGCA--GTTT-CTTAAAAAGTTAAAC--ATACACCTACCA-- -TATGA--TCCAGCCATTCCACTCCTTAG-TATTTACCCCAGAAA-AAT--TAAA----- -------------------ACCATATG-TCTAT--ACAAAAACTTG----------T--- ---------ACATG--AATGTTCATAGCAGCTTTATT---ATAAACA-GCCCAAAATTGA AAAAAAAAAAACCTAAA-TGTCCATCA---ACAGGTG-----AATGGATAAA--CAAAC- TG---------------------------------------------------------- --------------------TGGTATATCC----ATACAATGGAATAC--TACTCA-GCA ATAAAA----------------------AGGAATGAACTACTGATACATACAACAACATG GATGAATCTCAAAAGCATTATGCTGAGTGAAAGAAGCCAGACAAAAAAGGTGATACATGC AGCAACAACATGGATGAAT-C---T----------------CAAAATCATTATGCTGAGT GA-------------------------------------------------------AAG A----------------------------------------------------------- ----------AGCCA--GACAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAGA---- -----------------------------GTACATAC-TGTATG--------ATT----- ------CCATT---TAT------------------------ATG-----ACATTCTAGAA A-------A--------------GGCAAA---------------C--------------- ------------------------------------TTATATATATTGA-----GTGA-- -------CA------------------------------------------GAAAGC--- -AGATCAGTGGT---TGCCT-----GGGGCTGGG---------GGGGGG----------- ----------GG------------------------------------------------ --GGG---------GGAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TGA----------------------TT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GCAAAGG---------------------------------------------- --------GGCA----CGAGGG------------------------AACTTTTGGGGGTG ATGGAT---TGGATGTGTTCTGTATCTTGATTGTGGTGGTGGTTTCATGAGT-------G TA------------------------------------------------------TATA TTTGTTATAT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GTCAAAATTCATC-- -------------------GAAT--TGTACA--------CT------------TTAAA-- --------TGGGTGAATTTTATTGTAAAT------------------------------- -----------------------------------------------------TATACCT CAATA-----AAGCTG-------------------------------------------- -----------TTTAAT-------------------------------TGTTTT------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------TA------AA- -------AA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MB8 ---------------------------AAGGAGAAAAAAATG--AAGAAAA-GTGAACAG AGCCTAAAA-----GGGACCTG--------TGGGACACCATC------------------ ---------------------AAGC---------AGACCAACAGACCAA--------CTT AT--ACATTATGGGA-----ATATTAGAAGGAGAAGAGAGAGAG-----------AAAGG AGCA---GAGAGATT--ATTCAAAGAATAATAATG-----------------GCTGAAAA CTTCC----------------CAAGTTTATTGAAAAACATTAATCT-------------- ------------ATACATCCA-----------------GG--AAGCCCAGAGAACTCCA- ----------------------------------------------A-----GT-AGAGA TAAACACAAA---------------------------AGGATCC-ACAAATTGACACATT GTAGTAAAATTATTGAAAGCCAAAGACAACGAGGAAATCCTGAAAGCAGA-------AAG CAAAAATTAACTCATTCA---CAT------------------------------------ ---A---CAAGGGAACCCCAAATATCAGGTGA------------------ACAGCTGACT T--CTCATCAGGAACAATGGA---------CTCCAGAAGGTAATGGGATAATATA----- ------------TTTAAAGTGCTTGAAGGAAAACTCATGTCAGACAAGAATCCTA----- ----------------------------------TATCCAAGAAAACTATCTTTCAAAAA TGAAAGAAAAATA-----AAGACATTCCCAGATAAACAAAAACTGAGAGAGTTTGTTGCT AGCAGACATGACTT-ACAAGAAATGCTAAAGAAATTCCTTCAGGTT-------------- ---GAACAAAATAAGAAGATCTGTAAAACAAC---------------------------- ------------------------------------------------------------ --------------------TACTTAATAAAACTAATAAAAACCGC-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------TTTAAAAAAATGTTTAA--------------GTATCTATAAATGGTCT TAGAGGCAACAAATATCTAGAAATGTTCCTTAAAA----------------AAAAACACA TG-------------GA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------TCATGTAATGAATAAATAAATAAATATGTAGTCAAGAA AATATATTAAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------A TCTTAAGTC------TCCCATA--ATCAGAAACTAAAGTTAGAATATCAGGAAGAA---- ---------AAA------------------------------------------------ ---------------------------CTGTACTATTGTCCCAATGCAAATTTGAAGGAT GTCA-------------------GAGGTTTTGCAAAGGAAAAAAACAAACTGCAAAACAG AAAACTAAATA---TCTATTCCC-----AA-----AGAAACTA---------------AC TTAAT------------------------------------------------------- -------------------------------------TTGTCATAGAGTGTGAATAAGTT AAAAAATAAAGGTGCTTTAAAAAAAAATAAAGATAATGATGA------------------ ------AAAGCAATTGGAGAGAGATTGATGGATTCTT----------------------- ------------------------------------------------------------ -----------TGGAAATGAAGGCTGCAATGTAGGCTAGCTACTTTGCTAAAGT-GAACA ATAAAT-----------------A------------------AAGACAACTAGAAAGTAT ACTAATAAC----------TTCAAAACATAT------------ATCAAAAA--------- ------------CCGACATAAAG------------------------AACTATATCTTCA AATAA-------------TCCTAAATTTGATTGAAT------------------------ -------------------------------------------CTGTTGATAAAGCAATC T---ATACACCAGGGCATTATTAAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AAAAAAA------------------------------AAA T-----------AAGAAGCTAGCAATT--------------------------------- ------------------------------------------------------------ -------AATAAAATTGAATATGC------ACAAATAAAGAGAAATTCA----------- ------------------------------------------------------------ -----------AAGAATAC----------------------------------------- ------------------------------------------------------------ --CAAGTTAA-AGACTAAATAATTGAAGAAAAAA-------------------------- AAGTAAATAAACTATAAAATT--------------------------------------- -----------------AGGAGTATTATTACTTAAGGCATACTG---------------- ------CAACCAGGGAAAAAGACAAATCTAGTGTTGAATGTGAACTATACAAAACACAA- --------CCCAC-----AGA------------GAAAGTAAAACAACAAC---------- CCAG--------GGTACAA-------ATC-------ACAG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGT-GGGTACTA GAAT------TTGAGAAA------GAGCTTTACCTAAGGTATCCAAAAT---AAAAAA-T AAAAGTA---AGCTACATTAAATGACCCCAAAGGCTGA---------------------- --------------------------CACGTGTACAAGGGATCA---AAAAAAGG----- ----------------------------------------T------------------- -------AATATCTACTATATTTAA---TTTCTAACAAA--------------------- ----------------------TATAG-------------AATAACATTCAAAAAACAGT --------------------------AAAATTTGACACTAAAAGGAAAAA---------- -----AAAGTGAAAA--------------------------------------------- -------------------------------------TGAAA---------AGTAA---- -AAGTACAGAT----GCGAGAGATAACAAAA-------AGAT------------------ --------------------------------------------ATTTAACAAATGAAA- -----TGAGA--AATT------------------TGAAAAGATAAATCAAAAATAT-TTC AAAAGTT----------------------------------------------------- ------------------------------------------------------------ ----ATAG---GAATAAATAAAA-C--AACAGAT------TCAGAAGAAAAGTAAGA--- ------------------CATTACAGTGAATGAAAAG---ATAAAGAAAAAGATAGCATC TGG-AAAAAGGACCAAAAAAAAATATATGAATAAAATAAGTAACAACAGAAAAGAAAAAA GGTATAGAGGGGAACAAAAGCATATGTAAAG--------------AGAAGGCGAAAAATG GAAGAAAAATGATGATACATTAAGACACATAAAA--A--------AAAATAAGGCA-A-T AAAAAACCCCAA---T--------------------TTATTGATACATAG--TAATTTAA ATAT---GGAAAAAGAAAAACCAAC---ACAAAT-TAACA--------AAA--------- ---A-TCGGAAGA-----ATTCCACGCTAA----------------------------CA TACATCCCCTTCAAGGT------GTT-GGAAG---------GGAAAGTCAATGGGCTGAA AGAAAGGAATCCAAG--AAAGACATT---------------------------------- --------GAAAGATACATAGACA---AACAAAGA--------------GCATTGC---- TAC----------AGTT--------------GATAAATTATGATAGACAATAC--AAGAA AGTATCTTGTGCCTCCTTACCT--ATATTAACAAACATCCA-TACAAAGTG--------- ----ACT-TGTAATAGA-------TTAAAA--T-ATT-GTATAGAGAT------------ -AA--TT--CAA--ACATGAAA--------TATTTTAAAATAGACAACCTA--------- --GAAAAG--ATGC-----TGTA-GAAATAA-------AGA-TCAAATGTAG-------- ---TAAAA-TAAAACTAAAAAA-TCATTTTGTAAGAAAACAAATTAACTTA--AGGAAA- -CA--------------AAAAGA----------------------AATAA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AA GTA-------ATAAAT------------------------AATAAAATTTATGCTACAAA CACGATAAATTTATTTTTTATCTTCTTTTTTTTTTTATTTTTATAAAATAC--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ATAAAAAAAAGAAATAAAAAA AAAA-------------------------------------------------------- ------------------------------------------------------------ ------ATTATTAAGTATGGAGTTTGTAGCGTTTAAAGTTTGAATAAAAGTAAAACTACA AAAAGGGGGAAAGGA-----------------AATGGAACTATATTGGAGTAGCG----- ------------------TTTCTCTA---------------------------------- ----------TCTCACTGGAATTAAGTTAGTATTAATCTG-------------------- --AAGTAGAATA------TCATAAG---------ATAA-AATATGAATTGT--------- -------------------AAGCCGTCAAG------------------------------ ------CTCCACATCAGGAAATAACTAAAAAAGAC-----------AAATTAAAAT---- ------------AATTAAAGTGT------T---------------AAACTAGTAAATTTA ----GACTTACTATAAAATAAAGGAGAAGAG-------AAAAAGGGG-----AACAAAAA AGACATGAGACATGTAGCAAAAAAAAATT-------------------------AAA--- --------------------------------AAAGGTAGATATATGACAGAGCA----- --------------------GGAGTAA--ATCC-AATGATAGAAATAA------------ -------------TCAG-ATTAAATG-GGAATAGACT--AAACAT---GCCACTCAAAAG GCAGAGAC--TATCATAT-TGGAT----------AAAAAATAACAAGATCCAACTA---- ---TAT-ACTGTCTATAAAAGAAAAAATTT-TAGAT--TCAATGATAAAAATAGATTGGA AG--TTAAAAAA--ATGAAAA-AATAATTCCATCCAAAAGC------TAACA-------- -------------ATAAG-AAAGCTG--AATGGGCTATACTAATATC-AGACAAAATAGA CTTTAAG-AT----------AAATAATATTACTAGAGAC-AAAG-AGGGACATTTTAT-- ----AATGATAAAAGTGGAATCAATCTATC--ATGAAG--------AT-ATAACAATTAT AA-----------------ATGTATACGAACCTAACAACAGAGCCCCAAA--ATGTATGA AGCAAAAACTGACAGAAATGAAGAGAAATGAAAACAACATAACTAACGGAAAAATAATAG TTGGAGACTTCAATACCCCAC-----TGTCAATAATGGATAGA----------------- ----ACAACTAGAC---------A-----GATTAACAAGGAAATAAAAGACTTA------ --GACAACACTATCAACCAACTTGAC-CTAACAG--ATATCTATAGAA--AGTTCCAACC AACAAGAG---TAGAATATACATTCTTTTCA-------AGTGCACGT---GGAACATTCT C------CAGGATAGACCATATGCTAGGCCACAACACAAG-------------------- -TATCAATAAAATTAAAAAAA--TACAAGT----------------AATACAAA------ -ATATGTTCTCT---GACCACAATGGAA-TAAAATTAGAAATCAATAACA--------GA A-------------AA-AAAATTG---GAAAATTCACAA----ATATGTGGAAATTAAAC AACATA-CTCCTAAA---TA-ACCAATG--GGTCA---AAGAAAAAAT--CAA-AAGGAA AATAAGAAAATACTTT---GAAAT------------------------GAATGAAAATAA -AAACACAACATATATCAAAAATTATTGG-GATGCAGCTAAAGCAGTGCTTAGAGGGAAA --TTTATAGCTGTAAATGCCTATATTAAGAAAG---AAGA--AAGATCT---CAAATCAA ------AAACCTAACCTTCCACTTTAA---AACACTAGAAAA---AC---AAGAGCAAAA TAAACCTA-AAGCAAGCA------------GAAGAAAGGAAATAAT-AAAGATTAGAGTA GAAATA---AATGAAATAGAGAATAGAAAAA-CAA---TAGAGAAAATC-AATAAAACCA -AAATT-------TGGTTCTTTGAAAAGATCAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGACAAACTT---TTAGCTA------GATT-------------- GATCAAAAAAAAAAA---A---GAGAAAAAAATTACTAAAATCAAAAAGGAAAAGACTAA AATTCCAAAA---T---------CAGGAATGAAAGA------GGAAA---CATTACTACC A--------ACCCTTACAAAAATA-AAAAGGATT--ATAAA---------GGAAT----- -------------------ACTATGAACAA-TTGTATGCCAATAA--AT---TAGATAAC TTAG---ATGAAAT--GGACAAATTCCT--A---GAAAGA---------CAC-----AAA TTACTG------AAACTGACTCAAGAAGAAATAGAAAATCTGAAT--------------- --------AGACCT------A------TAACAAGTAAAGAGAT----TGAAT--TAGTAA -TCAAAAAACTACCCACAAAGAAAAG--CC-CAGGCCC--AGATGGCTTCACTGGTGAA- TTCTA------------CCAAATATTT----AAAGAA---TTAATA-CTAATT-----C- ----TTCACAAACTCTTCCAA-------AAAATAG-AAGAAGAGGA-----------AAC ACTTCCCAACTCATTCTATGAG---------GCCAGTAT---TATCCTGATACC--AAAA C-----------------------CAGAC--AAAGATA-TCACACAAAA---------AA AAAAAAAACT---------------------ACA------GACCAATAT--CCC----TT ATGAATATAGAT------------------------GCAAAAATCC-TAAA--------- ------AAAATAACTAGC-AAACTG------------------AA--T------------ ---C-CA--GCA-------------ACATAT-------------AAAATGATATA--TCA ----TGAC------------CAAGTGGGA-TTTATCCCAGGAA-TGCAAG---------- -------------GTTGGTTT-AAC-----ATCTGA----AAATCAATTAATGTA--ATA CATCAT---------A------TCAATAG----AATAAAGAAAAAAAAT---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAAG---CATTTGACAA---AA TCCAACACCCTTT-------------------CATGA---------T-AAAAAC-ACTCA --ACAAAAATAGAATAGAAGGGAACT-----TCCTCAACCTGAT---------------- -----------AAAGAGCAT-CTAT-GAAAAATCCACAGC-----------TAACAT--C ATACTTAATGGTAAAAG-A-----CTGAATGC-TTTC---CCCAAAAGAT----CAGGAA CAAGGCAAAGATAT-------CCACTTT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTTCTATTCAA-CATT--GTACT---GGAGG TTCTAGCCAG--------GGCAATTAG------GCAAGAA---AAAGA--AATAAAAGGC ATCCAGATTGGAAA-------GGAAGAAGTAAAA--CTATCTCTA-----TTTACAGATG AC--ATGATCTTG-------TATATAGAAAATCCT---------------AAGGA---AT CCACTA---------AAA--AACTATTAGAACT---------AATAAA--TGAGTTCAGC AAGG--TT-------------------------GCAGGATACAA--------------GA TCAATAT------------ACAAAAAT----CAATTGTATTTC--TA-TACACTAG--CA ATGATCAAAAAAA------------------AAATAAAAATTTAA----AAAACAATTCC ATTGACAATAGC-ATCAAA---AAAAATAAAATATTTGGAAATAATTTA--------AAA -AAAAAAAGGAAAACATTTA----AACTTGAA--ATTTCTAAAACATTGTTG-AAAGAAA TTAAAGA-----------AG------------------ATCT--AAAT--AAATGGAAAG ACAT------C---CCATGTTCATG------GATTGGAAGACTT-----AATA-TTGTT- ------------------------AAGATGGCAA-TA-CTCCCC-AA------------- ----ATTGATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------CCCAGCT- GA------------CTTCTT---------------------------------------- --TGTAGAAATTG---ACA------AGCTGGTCTTAAAATTTTATGTAGAA-------AT AAAAGAGACCCA---GA--ATAGCCAAAACAATCTTGAAA-AAAAGAACA---AAGT--T -------GGAGGACTCACA---CTTCCCGATTTCAAAAC-----TTACTACAA---AGCT ACAGT-AATCAAGAC-AG------TGTGGTACTGG--CA-----------------TAAG GATAGACA------TATAGAT--CAATGGAATAGAATTGAGAGTCC------AG--AAAT AAA---CCCTTACATTTATG----GTCAAT--TGATTTTC---GACAAG--GGTGC--CA AGACCATTC--AATGG-----GGAAAGA----ATAGT--------CTTTT--CAACAAAT GGTTCTG----------G-GACAAC--TGG-A-TAACCA---------------CATGC- AAA---------AAA--ATGAAATTTGACCCCT----TCCT---------------CACA CC--ATATACAAAAA-TTAACT-CAAAATGGATCAAAGACCTAAATGTA--AGAGCTAAA ACT-AT------------------------AAAACTCTTAGAA----------------- ------GAAA--ACATA------A---------GAG---------TAAATTTTCATGAC- --CTT-----GG-ATTTGGCAATGGATTTTTATTAAATGAAATCA-AAA----ACATAAG CAAAAAAAGAAAAAA--A------AT---AGAT--AAA-TTGGACTTC--AT-------- -------------------------------------------------------C-AAA ATTAAAAACTT-TTGTG---CTTC-AAAGGACACCATCAAG-AAAG-TGAAAAG-ACAAC CCAC--AGAA--T-GGGAG--AAAATATTT---GCAAATCATATAT--------CTGATA AGGGACTTG-------TATCTAGAATATATA--AAGAATTCTTAT-----ACAAC----- ----------------------TCAATAATAA------AAAGAC------------A--- AATAACCCAATTTAAAA----------AGTGGGCAAA-----------GGA--TTTGAAT ---AGACATTTCTCCAAAGAAGATATACAAA--------------TGGCCAAT-AAGCAC ATGAAAAGATG----CTCAACATCATTAG-TCATCAGGGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCACTTCATACCCACTAGGATGACTA-- ----TAATTAAAA---AGACAGATA-----------ATAACAA--GTG--TTGGC-A--- ---------------AGAATGTGGAGAA-------------------------------- -----ATTGGAACCCTCAT-ACACTGCTGG--TGGGAA---------------------- -------------AATGTA-----------AAATT-GTTCCGCC--------ACTTTGG- -------AAAAAC-AGTTGGTC--ATTTCCTAAAAAAGTTAAAC--ATAGAGTTACCA-- -TATGACCCCCAGCAATTCCACT-CCAGA-TATATA-CCCAAGAG-AAA--TGAA----- -------------------AACATATA-TCCAC--ACAAAAACTTG----------T--- ---------ACATGAATATGTTCATAGGAGCCATTTT---CATAATA-GAAAAAAGGT-G GA--AACA--ACCCAAA-TGTCCATCA---ACTGATG-----AATGGATAAA--CAAAA- TG---------------------------------------------------------- --------------------TGGTATATCC----ATACACTAGAAAAT--TATTTT-GCA ATAAAA----------------------A-GAATGAAGTACTGATACAT----------- ------------------------------------------------------------ -GCTACAACATGGATGAAC-C---T----------------TAAAAACATTATGCTAAGT GA-------------------------------------------------------AAG A----------------------------------------------------------- ----------AGCCA--GTCAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAGA---- -----------------------------CCACATAT-TGTATG--------ATT----- ------CCATT---CAT------------------------AATGAAATTT---CCAGAA T-------A--------------GGCAAA---------------T--------------- ------------------------------------CTATA-------------GAGA-- -------CA------------------------------------------GAAAGT--- -AGATTAGTGGT---TGCTT-----AGGGATGGG---------GGGGGG----------- ------------------------------------------------------------ ------------GGGGGG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TGA----------------------TT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GCTAAAG---------------------------------------------- --------GGTA----TGGGGTTT------------------------CTTTTTGGGGTG ATGAAA---------------ATGTTCTAAAATTGATTGTGGTGATGGTTGC-------A CAT-----------------------------------------------------ATCT GTGAATATAC-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------TA-AAAAACATTG-- -------------------A-AT--TGTACA--------CT------------TTAAA-- --------TGGGTGAATT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------GTAT-GGTATG-------------------------------TGAGTT------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ATATC----TCAAT------------- -------AAGGCTTTTAA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PB1 ------------------------------------ATCATG--GCGGATG-GGAGGCAG GACTAGATTGC---AGCTCCGG--------AC---------------------------- ---------------------AGAG---------CAGCATGCGGAGGCT--------CGC AT--TGTGAATTT-T-----AGCTCCAGATCGACTGCA--AGAA-----------CAAAC CAGC---AATCCCGAGAGG---------------A--------------CCCACAGACCC T--------------------CTGAAGGAAGCGGA------------------------- ------------CTGCTCCTG------------------------------CAGGACCC- -------------GGGAGACACCCCAAATA----CTGTGAGTGCCCC-----AACTGCGG AAGTGGGAAAGGGAGA------C--------------CCTCCTC-TCCCGAACACACACC C-------------------------CCACTGGAGAAGCTGAAGGTCTTT------TGCA GGAGAAGTTTCCGACTTT--ACCT------------------------------------ --------------------------------------------------GGAGCTGAGT CAATTTAGAGAGCCGAGCGAA---------ATACAGGGGTAGAGGAAGCAGCAGAAAGGC CCTGGGAGCTCGCTGGGTCCCCAAGC---------------------------------- ----------------------------AGGCCATTCCTGCCTGGCACCACAGGGATCCA TCGGGAG---------------------------------------GGTGGCCAGAGGAG CAGGGGGTAAAACT-CCACAGGGAGAAGGAAATCTCTAGCTGAACTTTGTAACAATT--- ---TGAACGGGGTGAGAAGCCTCCTGGCCAGAACTCGGGGAGGGTGCAAATCCGGTGTG- ------------------------------------CAGACT------------------ -------------------CCACAGGCAGGGGAAGAACCAAGCCCTTTTCTTTCGCAGCT GGGAGGCGGGTAGCCTGGGGCAAGTTTTCAAGCCCGTCTCGCCCTCCGCCTGGAAAC--- --------------------------------------AGACTCGGGGCTGTTGGGGGGG GCACGGTGGGAGTGAGACCGGCCCTTCGGTTT-----------GCGTGGGAGCTGG---- -------------------GTGAGGCCTGTGACTG------------------------- ---------------------------------CCGGCT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------TTCCCCCACTTCCCTGA-------CAACCTGCATGACTCAGCA GAGGCAGCCAT------------------------------------------------- --------------------------AATCCTCCTAGGTACACAACTCCAGTGACCTGGG AATCTCACCCCCA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------TCCCCCA--CAGCAGCCGCAGCAAGACCCGCCCAAGG-------- ---------AGAGTCTGAGCTCA--------------GACATGCCTAGCCCTGCCCCCAC CTG-----------------ATGGTCCTTCCCTACCCACCCTGGTAGCAGAAGAC----- ------------AAAGGGCATATAATCTT---------------------------GGGA GTTCTAGGGCC---CCGCCCACCGCCGGTCCCTCTCCATACTA---------------CC ACAGCTGATG--CTCTCT---------------GGAAAG--------------------- --------------------------------------CGCCACCTCCT----------- ------------------------------------GGCAGG------------------ ------AGGCCAACCAGCACAAAAATAGAGCATTAAACCACCA----------------- ------------------------------------------------------------ -----------AAGCTAAGAACCCTCA----------------------------TGGAG TCCATT------------------------------------GCACCCCCCTGCCACCTC CACCGGAAC----------AGGCGCTGGTATCCACGGCTGAGAGACCCATA--------- ------------GACGGTTCACA--------------------TCACAGGACTCTGTGCA GACAA-------------CCCCC-----AGTACCAG------------------------ ----------------------------------------------CCCGGAGCTGGGTA G---ACTCGCTGGGTGGCTAGACCC----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AGAAGAG------------------------------AGA C-----------AACAATCACTGCAGTTTGGCTCACAG---------------------- ------------------------------------------------------------ -----GAAGCCACATCCATAGGAA------------AAGGGGGAGAGTACTACATC---- ------------------------------------------------------------ -----------AAGGGAAC----------------------------------------- ------------------------------------------------------------ --ACCCCGTG-GGACAAAA----------------------------------------- ---GAATCTGAACAACAGCCT--------------------------------------- TCAGCCCTAGACCTTCCCTCTGACAGAGCCTACCCAATGAGAAG---------------- ------GAACCAGA-------AAACCAACCCT-------GGTAATATGACAAAACAAGGC TCTTCAACACCCC-----CCA------------AAAATCACACTAGTTCA---------- CCAG---CAATGGATCCAA-------ACC-------AAGA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGA-AATCCCTG ATTT------ACCTGAAA------AAGAA------------TTCAGGAG---GTTAGT-T ATTAAGC---TAATCAGGGAGGG----ACCAGAGAAAG---------------------- ------------------------------GCGAAGCCCAATGC---AAGGAAAT----- ----------------------------------------C------------------- ----CAAAAAATGATACAAGAAGTG---AAGGGAGAAAT--------------------- ----------------------ATTCA-------------AGGA------AATAGATAGC --------------------------------------TTAAAGAAAAAA---------- -----CAATCAAAAA--------------------------------------------- ------------------------TTCA-GGAAACTTTG------------GACAC---- -ACTTTTAGAA----ATGCGAAATGCTCTGG-------AAAG------------------ --------------------------------------------TCTCAGCAATAGAAT- -----TGAAC--AAGT------------------AGAAG---------AAAG-AAA-TTC AGAGCTC----------------------------------------------------- ------------------------------------------------------------ ----AAAGACAAGGTCTTCGAAT-T--AACCCAA------TCCA---------ACAA--- ------------------AGACAAAGAAAAA---AGA---ATAAGAAAATA--------- TGA-ACAAAGCCTCCAA--GAAGTCTGGG-ATTATGTT-----------AAACG--ACCA AACCTAAGAA-TAATCGG--TGTTCCTGAGG-----------------AAGAAGAGAATT CTAAAAGCTTGG---------AAAACATATTTGG--G--------GGAATAATCGA-G-G AAAACTTCCCCGGCCT--------------------TGCTAGAGACCTAG--ACATCCAA ATAC-----AAGAAGCACAAAGAAC---ACCTGG-GAAAT--------TCA--------- ---T-CGCAAAAA-----GATCTTCGCCTA----------------------------GG CACATTGTCATCAGGTT------ATC-CAAAG---------TTAAGACGA---------- ------------AGG--AAAGAATCT---------------------------------- --------TAAGAGCTGTGAGACA---GAAGCACC--------------AGGTAAC---C TAT----------AAAG--------------GAAAACCTAT--CAGATTAA-C--AGCAG ATT--------TCTCAGCAGAA--ACCCTA-CAAG--CTAG-AAGGGATTG--------- ----GGG-CCCTATC-T-------TCAGCC--T-CCT-CAAACAAAAC------------ -AAT-TA--TCA--GCCAAGAA--------TTTTGT----------ATCCA--------- --GCGAAACTAAGC-----ATCA-TATATGA-------AGG-AAAGATACAGTCTTTTTC AGACAAAC-AAATGCTGAGAGA-ATTCGCCATTACCAAGC---CACCACTAC-AAGAACT GCT--------------AAAAGG----------------------AGCTC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------CTTG---------------------- ------------------------------------------------------------ ----------------------------AAACAAATTCCTGGAAACACATCAAAACAGAA CCTCTT------TAAAGCAT-------------------------AAAT-----CACACA ----GGACCTATAAAACAAAAATACAAGTTA-------AAAAGCAAAAACAAAAAACAAA AAAACCAAAGTACACAGGCAACAAAGAG-------------------------------- ------------------------------------------------CATGATG----- --------------------AATGCAATGGTAC-CTACATTTCAATAC------------ -------------TAAC-ATTGAATG-TAAATGGCCT--AAATGC---TCCACTTAAAAG ATACAGAA--CTGCAGAA-TGGAT------------AAGAACTCACCAACCAACTA---- ---TCT-GCTGCCTTCAGGAG-ACTCACCT-AACAC--ATAAGGACTCACATAAACTTAA AG--TAAAGGGG--TGGAAAA-AGGCATTTCATGCAAATGG------ACACC-------- -------------AAAAG-CGAGCAG--GGGTAGCTATTCTTATATC-AGACAAAACAAA CTTTAAA-GC----------AACAGCAGTTAAAAGAGAC-AAAG-AGGGACATTATAT-- ----AATGGTAAA---AGGCCTTGTCCAAC--AGGAAA--------AT-ATCACAATCCT AA-----------------ACATATATGCACCTAACACTGGAGCTCCCAA--ATTTATAA AACAATTACTAATAGACCTAAGAAATGAGATAGACAGCAACAC---------AATAATAG TGGGGGACTTCAATACTCCAC-----TGACAGCACTAGACAGG----------------- ----TCATCAAGAC------AGAA-----AGTCAACAAAGAAACAATGGATTTA------ --AACTATACCTTGGAACAAATGGAC-TTAACAG--ATATATACAGAA--CATTTCATCC AACAACCA---CAGAATACACATTCTATTCA-------ACAGCGCAT---GGAACTTTCT C------CAAGATAGACCATATGATAGGCCATAAAATGAG-------------------- -CCTCAATAAATTTAAGAAAA--TTGAAAT----------------TATATCAA------ -GCACTCTCTCA---GACCACAGTGGAA-TAAAACTGGAAATCAACTCCA--------AA A-------------GG-AACCTTC---AAAACCATGCAA----ATACATGGAAATTAAAT AACCTG-CTCCTGAA---TG-AGCATTG--GGTCA---AAAACGAAAT--CAA-GATGGA AATTAAAAAATTCTTT---GAACT------------------------GAATGACAATAA -TGACACAAC--CTATCAAAACCTC-TGG-GATACAGCAAAGGCGGTGCTAAGAGGAAAG --TTCATAGCCCTAAATGCCTACATCAAAAAGA---CTGA--AAGAGCA---CAAACTGA ------CAATCTAAGGTCACACCTCAA---GGAACTAGAGAA---AC---AAGAACAAAC CAAACCCA-AACCCAGCA------------GAAGAAAGGAAATAAC-CAAGATCAGAGCA GAACTA---AATGAAATTGAAACAAACAAAA-AAAAAATACAAAAGATA-AATGAAACAA -AAAGC-------TGGTTCTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------T AA-----AA------TTGATAGACCA---TTAGCAA------GATT-------------- AACCAAGAAAAGAAG---A---GAGA-AAATCCAAATAAC-------------------- -----CTCAC---T---------AAGAAATGAAACA------GGAGA---TATTACAACT G--------ACAC-CACTGAAATA-CAAAAGATC--ATTCA---------AGGCT----- -------------------ACTATGAACAC-CTTTACGCACATAA--AC---TAGAAAAC CTAG---AAGAGAT--GGATAAATTCCT--G---GAAAAA---------TAC-----AAC CCTCCT------AGCTTAAATCAGGAAGAATTAGATACCCTGAAC--------------- --------AGACCA------A------TAACAAGCAGCGAGAT----TGAAA--TGGTAA TTTAAAA--TTACCAACAAAAAAAAG--TC-CAGGACC--AGATGGATTCACAGCAGAA- TTCTA------------CCAGACATTC----AAAGAAGAATTGGTA-CCAATC-----C- ----TTTTGACACTATTCCAC-------AAGATAG-AGAAAGAAGG-----------AAC CCTCCCTAATTCATTCTATGAA---------GCCAGCAT---CACCCTAATACC--AAAA C-----------------------CAGGA--AAGGACA-TAAC----CA---------AA AAAGAAAACT---------------------ACA------GACCGATAT--CCT----TG ATGAACATAGAT------------------------GCTAAAATCC-TTAA--------- ------CAAAATACTAGC-TAACCG------------------AA--T------------ ---C-CA--ACA-------------ACATATC---------AAAAAGATAATCCA--CCA ----TGAT------------CAAGTGGGT-TTCATACCAGGGA-TGCAGG---------- -------------GATGGTTT-AAC-----ATACGC----AAGTCAATAAATGTG--ATA CACCAC---------A------TAAACAG----AATTAAAAACAAAAAT---CACATGA- ----TCATCTC---AATA----------GATGCAGA-AAAAG---CATTCGACAA---AA TCCAGCATCCCTT-------------------TATGA---------T-TAAAAC-TCTCA --GCAAAATCGGCATACAAGGGACAT-----ACCTTAATGTAAT---------------- -----------AAAAGCCAT-CTAT-GACAAACCCACAGC-----------CAACAT--A ATACTGAATGGGGAAAA-G-----TTGAAAGC-ATTC---CCTCTGAGAA----CTGGAA CAAGACAAGGATGC-------CCACTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTCTTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATCAG------ACAAGAG---AAAGA--AATAAAGGGC ATCCAAATCGGTAA-------AGAGGAAGTCAAA--CTGTCACTG-----TTTGCTGATG AT--ATGATCGTT-------TACCTTGAAAACCCT---------------AAGGA---CT CCTCCA---------GAA--AGCTCCTAGAACT---------GATAAA--AGAATTCAGC AAAG--TT-------------------------TCCGGATACAA--------------GA TTAATGT------------ACACAAAT----CAGTAGCTCTTC--TA-TACACCAA--CA GCGACCAAGCAGA------------------GAATCAAA-TCAAG----AACTCAACCCC TTTTACAATAGC-TGCAAA---AAAAATAAAATACTTAGGAATATACCT--------AAC -CAAGGAGTCGAAAGACCTCT---ACAAGGAA--AACTACAAAACACTGCTG-AAAGAAA TCATAGA-----------TG------------------ACAC--AAAC--AAATGGAAAC ACAT------C---CCATGCTCATG------GATGGGTAGAATC-----AATA-TTGTG- ------------------------AAAATGACCA-TA-CTGCCA-AA------------- ----AGCAATCTACAAA---TTCAATGCAATCCCCATCAAAAT---------ACCACCA- TC------------ATTCTT---------------------------------------- --CACAGAATTAG---AAA------AAACAATTCTAAAA-TTCATATGGAA-------CC AAAAAAGAGCCC---GC--ATAGCCAAAGCAAGACTAAGCAAAAAGAACA---AATC--T -------GGAGGCATCACA---CTACCTGATTTCAAACT-----ATACTATAA---GGCC ATAGT-CACCAAAAC-AG------CATGGTACTGG--TA-----------------TAAA AATAGGCA------CATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAT AAA---CCCAAATACTTACA----GCCAAC--TGATCTTC---GACAAA--GCAAA--CA AAAACATAA--AGTGG-----GGAAAGG----ACACC--------CTTTT--CAACAAAT GGTGCTG----------G-GATAAT--TGG-C-TAGCCA---------------CATGT- AGG---------AGA--ATGAAACTGGATCCTC----ATCT---------------CTCA CC--TTATACAAAAA-TCAACT-CAAGATGGATTAAGGACTTAAACCTA--AGACCTGAA ACT-AT------------------------AAAAATTCTAGAA----------------- ------GATA--ACATT------G---------GAA---------AAACCCTTCTAGAC- --ATT-----GG-CTTAGGCAAGGATTTCATGACCAA-GAACCCA-AAA----GCAAATG CAATAAAAACAAA----G------AT---AAAT--AGC-TGGGACCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-TTGCA---CGGC-AAAAGGAACAGTCAGC-AGAG-TAAACAG-ACAAC CCAC--AGAG--T-GGGAG--AAAATCTTC---ACAATCTATACAT--------CTGACA AAGGACTAA-------TATCCAGAATCTACA--ACGAA--CTCAA-----ACAAA----- ----------------------TCAGTAAGAA------AAAAAC------------A--- AACAATCCCA-TCAAAA----------AGTGGGCTAA-----------GGA--CATGAAT ---AGACAATTCTCAAAAGAAGATATACAAA--------------TGGCCAAC-AAACAT ATGAAAAAATG----CTCAACATCACTAA-TGATCAGGGA-AAT--GCAAATC-AAAACC ACAATGCGA---------------------TACCACCTTACTCCTGCAAGAATGGCCA-- ----TAATCAAAA---AATCAAAAA-----------ACAGTAG--ATG--TTGGC-G--- ---------------TGGATGCGGTGAA-------------------------------- -----CAGGGAACACTTCT-ACACTGCTGG--TGGGAA---------------------- -------------TGTA-------------AACTA-GTACAGCC--------ACTATGG- -------AAAACA-GTGTGGAG--ATTC-CTTAAAGAACTAAAA--GTAGAACTACCA-- -TTTGA--TCCAGCAATCCCACTACTGGG-TATCTA-CCCAGAGG-AAA--AGAA----- -------------------GTCATTAT-TCGAA--AAAGATACTTG----------C--- ---------ACACG--CATGTTTATAGCAGCACAATT---CACAATT-GCAAAATCGT-G GA--ACCA--ACCCAAA-TGCCCATCA---ATCAACG-----AGTGGATAAA--GAAAC- TG---------------------------------------------------------- --------------------TGGTATATAT----ATATGATGGAATAC--TACTCA-GCC ATAAAA----------------------AGGAATGAATTAACAGCATTT----------- ------------------------------------------------------------ -GCAGTGACCTGGATGAGA-T---T----------------GGAGACTATTATTCTAAGT GA-------------------------------------------------------AGT A----------------------------------------------------------- ----------ACTCA--GGAAT-------------------------------------- ------------------------------------------------------------ --------------------------------------------------GGAAAA---- -----------------------------CCAAACAT-CGTATG--------TTC----- ------TCACT---GAT------------------------ATGTGGGAGC---CTAAGC T-------A--------------TGAGGA---------------C--------------- ------------------------------------GCAAA-------------GGCA-- -------TA-------------------------------------------AGAAT--- -GATACAATGGA---CTTTG-----GGGACTTG----------GGGGGA----------- ----AGAGTGGG------------------------------------------------ --AGG-------GGGGCG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGG------------GATAAAAGACTA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CAAATAT---------------------------------------------- --------GGTG----CAGTGTAT----------------------ACTGCTCGGGT--G ATGGGT--------------------------------------GCACCAAA-------A TCT-----------------------------------------------------CACA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AATCACCACT-- ---------------------AAAGAACTTA--------C-------------TCATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACC------------------------------------------------------- ------AAAT-ACCACC-------------------------------TGTACC------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------CCAATAA----CTTATGGAA------AA- -------ATAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PB2 ----------------------------------GGAAGATG--GCAGATA-GGAGACAG GGCTAACGTGC---AGCTCCCA--------CTTGGACGAAC------------------- ---------------------AGAA---------CAGTGTGTGGAGACT--------CAC AC--TGTGAACTTTT-----GCTCCAAGAACCACCGCA--GGAA-----------CGTAC CAGG---AAAACCAAAAGA---------------A--------------TTCACAGATCC T--------------------TTGAAAGAAGCGGCATGCCACTGCA-------------- ------------------------------------------AACTTCACAAGACAG--- -------------GTGAAAAACTGTGAGTT----CCCAAAGTGT-----------GAGAG GGGGAA-------------------------------AACCTGC-CTCCGAACACACATC C-------------------------CCACTGGGGAATCTGAAAATCCAG----ATCACG AGAGAAGGATTTAACCTT--ACCT------------------------------------ -------------AGAGCTGAAATGGATTTAG------------------GGAGCTGCGT GAAATATAAAAGTAGAAGCAG---------CAGCAGGAAGAG------------------ ------------CCCTGCAGGCACTCCCAGTCTCCAGCTTGAGCCCAGG----------- ---------------------------GAAGCCATTCCTGACTTTATCTCACAGGGGCCC TTGGGGAAGGCAG---------------------------------CCAGCAGAACGGGG GAGGGGTCATAGGG-TGAAGGAAGCTTCCAACTAAACTTTGTGA---------------- ---TAATTTTGACTGGGCACAAATTTTCTTGAGCAGAATCCAGGGGG------------- ------------------------------------TAAACGGGAGCTGCTGCAGATACG AGTG---------------CTGCCTGCAGAAGAGGCGCTGCCTGTCTTGTGGGCAGACGG GGAGGGGTGAGGCCTGAAAGCCAT----------------GCTTGCTTTCTCAGCGG--- ------------------------------------------------------------ -------------------GGAAGCTTAT--------------GGCCTGGGGCAGGTTCG AGTTCCGTGCGCAGGCTGCCTGGATCTAAACTCGG------------------------- -----------------------CACTGTTAGTGGGGCACTGCAGGAGCGAGACCAGCCT CACCAACTGCGTGGGAGCTGGGTGAGGCCTTTCGCTA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CTGGCTGTCCCCCACTTCCCTGG-------CGAACTATATTACACAGCA GAGGCAGCCAT------------------------------------------------- --------------------------AATCCCCTCTGGAACATAACCCCATTGGCCTGAG AACCACCCCCTTCCCCCCATCCCCCACAGTGGCCAT------------------------ ------------------------------------------------------------ ------------------------------------------------------GGCAAG CCCCGCCCAAGGAGAGTCTGAGCTCAGACCCGCCTAACCCTGCCCCC------------A CCTGATGGT------TTTTCTC--TACCTGCCCTGGTAGCCGAACACAAAAGACAT---- -----------AAACTCTTGGGA--------------GCTTTATGGCCCTGCCCATCACC TGA--------------GAAACCAGAATACTTCCCCTGGCCAACTTAGGGCAAGCTT-AT ATCCCCCTGCTACTACCGCAGCTGGTGCTCTCTTG------------------------- ---------------AAAGCGCC------------ACCTCCTG---------------GC TGGAGGCCAA--CCAAC------------------------------------------- -------------------------------------TCAGGCCATTACAGCAACTCATG ACAGAATAACCCTGCTCCCAGGAAGGAGAAAACAACAGCTAA------------------ ------TTCCACTGCCTGCAACATCC---------------------------------- --------TGGCTAACCAGAGGTCCTGAGTCTGTCCACGTGACAACTTCACTGCTAGCAT AACCAGCATTTGAGAAAGC------------------------------------CAGCA CACTAAACATATCTACAACCAAGGACTCTCACAGAGTCTACTTCACTCCCCTGCCACCTC CACCAGAGC----------AGGTGCTGGTATCCACGGCTGGGAGACCTGAA--------- ------------GACGGATCACA-------------------TCACAGGACTCTTTGCAG ACATT-------------CCCCA---------GCAC------------------------ -------------------------------------------CAGCCCAGAGCCTGGTA G---CCCCGCTGGGTGGCTAGACCC----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AGAAGAG------------------------------CAA T-----------AACAATCACTGCAGTCTGGCTCTCAG---------------------- ------------------------------------------------------------ -----GAAGCCCCATCCCTAGGGG------------AAGGGGGAGAGCACCACATC---- ------------------------------------------------------------ -----------AAGGGATC----------------------------------------- ------------------------------------------------------------ --ACCCCGTG-GGACAAAA----------------------------------------- ---GAATCTGAACAGCAGGCC--------------------------------------- ----------------------------------------TTGA---------------- ------GTTCCAGATTTTTCCACTGAAATAGTCTACCCAAGTAATATGACAAAACAAGGT TCTATAAACCCCC-----CAA------------AAGTCCACACTAGCTCC---------- CCAG---CAATGGATCCAA-------ACC-------AAGA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGA-AATCTCTG AATT------GCCAGATA------AAGAA------------TTCAGAAG---GTTGAT-T ATTAAGC---TACTCAAGGAGAT----ACCAGAGAAAG---------------------- ------------------------------GTGAAAACCAACTT---AAAGAAAT----- ----------------------------------------T------------------- ----AAAAAAACAATACAGGATATT---GATGAAAAATT--------------------- ----------------------CTCCA-------------GAGA------AATAGATATC --------------------------------------ATAAAGAAAAAA---------- -----CAATCACAAC--------------------------------------------- ------------------------TTCT-GGAAA---TGAAA---------GACAC---- -ACTTAGAGAA----ATACAAAATGCACTGG-------AAAG------------------ --------------------------------------------TTTCAACAATAGACT- -----AGAAC--AAGT------------------AGAAG---------AAAG-AAC-TTC AGAGCTC----------------------------------------------------- ------------------------------------------------------------ ----AAAGACAAGGCTTTCAAAT-T--AACCCAA------TCAG---------ACAA--- ------------------AGACAAAGAAAAA---AGA---ATTTTAAAAAA--------- TGA-ACAAAGCCTCCAA--GAAATTTGGG-ATTATGTT-----------AAATG--GCCA AACCTAAGAA-TAATTGG--TGTTCCTGAGG-----------------AAGAAGAGAAAT CTAAAAGTTTGG---------AAAACTTATTTGA--G--------GGAATAATTGA-G-G AAAACTTCCCTGGCCT--------------------TGCTAGAGATCTAG--ACATCCAA ATAC-----AAGAAGCTCAAAGAAC---ACCTGG-GAAAT--------TCA--------- ---T-CACAAAAA-----GATCATCACCTA----------------------------GG CACATAGTCATCAGGTT------ATC-TAAAG---------TCAAGACAA---------- ------------AGG--AAAGAATCT---------------------------------- --------TAAGAGCTGTGAGACA---AAAGCATC--------------AGGTAAC---C TAT----------AAAG--------------GAAAACCTAT--CAGATTAA-C--AGCAG ATT--------TCTCAGCAGAA--ACCTTA-CAAG--CCAG-AAGGGATTG--------- ----GGG-TCCTATC-T-------TTAGCC--T-CCT-CAAACAAAAT------------ -AAT-TG--TCA--GCCAAGAA--------TTTTGT----------ATCCA--------- --GCAAAACTAAGC-----TTCA-TAAATGA-------AGG-AGAGATAAAGTCTTTTTC AGACAAAC-AAATGCTGAGAGA-ATTTACCACTACCAAGC---CAGCACTAC-AAGAAAT GCT--------------AAAAGG----------------------AGTTC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------CTTG---------------------- ------------------------------------------------------------ ---------------------------AAAACAAA-----------ACCTCAAAATACAC CAAAAT-------AGAACCTCCT------T---------------AAAG-----CATAAA ----TC------TCACAGGGCCT----ATAA-------AACAATAAC-----ACAATGAA AAATGAAAAAAAACAAGGTAT--------------------------------------- ------------------------------------------------TTAGGCA----- --------------------ACAACTA--GCAT--GACATCTCAATAC------------ -------------TAAC-ATTGAATG-TAAATGGCCT--AAATGC---TCCACTTAAAAG ATACAGAA--TGGCAGAA-TGGAT------------AAAAATCCACCAACCAAGTA---- ---TCT-GCTGTCTTCAAGAG-ACTCACCT-AACAC--ATAAGGACTCACATAAACTTAA GG--TAAAGGGG--TGGAAAA-AGATATTCCATGCAAATGG------AAACC-------- -------------AAAAG-CGAGCAG--GAGTAGCTATTCTTATATC-AGACAAAACAGA CTTTAAA-GC----------AACAACAGTTAAAAAAGAC-AAAG-AGGGACATTATAT-- ----AATGATAAA---AGGATTAGTCCAAC--AGGAAA--------AT-ATCACAATCCT AA-----------------ATATATATGCACCTAACACTGGAGCTCCCAA--ATTTATAA AACAATTACTACTAGACCTAAGAAATGAGATAGATGGCAACAC---------AATAATAG TGGGGGACTTCAATACTCCAC-----TGACAGCACTAGACAGG----------------- ----TCATCAAGAC------AGAA-----AGTCAACAAAGAAACAATGGACTTA------ --AACTATACCCTAGAACAAATGGAC-TTAACAG--ATATTTACAGAA--CATTCTACCC AACAACTG---CAGAATATACATTCTTTTCA-------TCAGCACAT---GGAACATTCT C------CAAGATAGACCATATGATAGGCCACAAAACAAG-------------------- -TCTCAATAAATTTAAGAAAA--TTAAAAT----------------TATATCAA------ -GTACCCTCTCA---GACCACAGTGGAA-TAAAACTGGAAATTAACTCCA--------AA A-------------GG-AACCCTC---AAAACTATACAA----ATACATGGAAATTAAAT AATCTG-CTCTTGAA---TG-ATCTTTG--GGTCA---ACAATGAAAT--CAA-GATGGA AATTAAAAAATTCTTT---GAACT------------------------GAATGATAATAG -TGACACAAC--TTATCAAAACCTC-TGG-GATACAGCAAAAGCAGTGCTAAGAGGAAAG --TTCATAGCATTAAATGCCTACATCAAAAAGT---CTGA--AAGAGCA---CAAATAGA ------CAATCTAAGGTCACACCTCAA---GGAACTAGAGAA---AC---AAGAACAAAC CAAACCCA-AACCCAGCA------------GAAGAAAAGAAATAAC-AAAGATCAGAGCA GAACTA---AATGAAATTGAAACAAAAAAAA-------TACAAAAGATA-AATGAAACAA -AAAGC-------TGGTTCTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGATAGACCA---TTAGCAA------GATT-------------- AACCAAGAAAAGAAG---A---GAGA-AGATCCAAATAAG-------------------- -----CTCAA---T---------TAGAAACAAAATG------GGAGA---TATTACAACT G--------ATAC-CACAGAAATA-CAAAAGATC--ATTCA---------AGGCT----- -------------------ACTATGAACAC-CTTTATGCACACAA--AC---TAGAAAAT CTAG---AGGAGAT--GGATAAATTCCT--G---GAAATA---------TAC-----AAC CCTCCT------AGATTAAATCAGGAAGAAATAGAAACTCTGAAC--------------- --------AGACCA------A------TAACAAGTAGCAAGAT----TGAAA--CAGTAA -TTAAAAAATTGCCAAAAAAAAAAAG--TC-CAGGACC--AGATGGATTCACAGCTGAA- TTCTA------------TCAGACATTC----AAAGAAGAATTGGTA-CCAATC-----T- ----TACTGAAACTATTCCAA-------AAGATAG-AGAAAGAGGG-----------AAT CCTCCCTAAATCATTCTATGAA---------GCCAGTAT---CACCCTAATACC--AAAA C-----------------------CAGGA--AAGGACA-TAAC----AA---------AA AAAGAAAACT---------------------ACA------GACCAATAT--CCC----TG ATGAACATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-TAACCA------------------AA--T------------ ---C-CA--ACA-------------GCATATC---------AAAAAGATAATACA--CCA ----TGAT------------CAAGTGGGT-TTCATACCAGGGA-TGCAGG---------- -------------GATGGTTT-AAC-----ATATGC----AAGTCAATAAATGTG--ATA CATCAC---------A------TAAACAG----AATTAAAAACAAAAAT---CATATGA- ----TCATCTC---AATA----------GATGCAGA-AAAAG---CATTTGACAA---AA TCCAGCATCCCTT-------------------TATGA---------T-TAAAAC-CCTCA --GCAAAATTGGCATAGAAGGGACAT-----ACCTCAAGGTAAT---------------- -----------AAAAGCCAT-CTAT-GACAAACCCACAGC-----------CAACAT--T ATACTGAACGGGGAAAA-G-----TTGAAAGC-ATTC---CCCCTGAGAA----CTGGAA CAAGACAAGGATGC-------CCACTTT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTTCTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATCAG------ACAAGAG---AAAGA--AATAAAGGGC ATCCAAATCGGTAA-------AGAGGAAGTCAAA--CTGTCACTG-----TTCACTGATG AT--ATGATTGTA-------TACCTAGAAAACCCT---------------AAAGA---CT CATCCA---------AAA--AGCTCCTAGATCT---------GATAAA--TGAATTCAGT AAAG--TT-------------------------TCAGGATACAA--------------AA TCAATGT------------ACACAAAT----CAGTAGCACTGC--TA-TACACCAA--CA ATGACCAAGCTGA------------------GAATCAAA-TCAAG----AACTCAACCCC TTTTACAACAGC-TGCAAA---AAAAATAAAATACTTAGGAATATACCT--------AAC -CAAGGAGGTGAAAGATCTCT---ACAAGGAA--AACTACAAAACACTGCTG-AAAGAAA TCATAGA-----------TG------------------ACAC--AAAC--AAATGGAAAC ACAT------C---CCATGCTCATG------GATGGGTAGAATC-----AATA-TTGTG- ------------------------AAAATGACCA-TA-CTGCCA-AA------------- ----AGCAATCTACAAA---TTCAATGCAATTCCCATCAAAAT---------ACCATCA- TC------------ATTCTT---------------------------------------- --CACAGAACTAG---AAA------AAACAATCCTAAAA-TTCATATGGAA-------CC AAAAAAGAGCCC---AC--ATAGCCAAAGCAAGACTAAGCAAAAAGAACA---AATC--T -------GGAGGCATCACA---TTACCTGACTTCAAACT-----ATACTACAA---GGCT ATAGT-TACCAAAAC-AG------CATGGTACTGG--TA-----------------TAAA AATAGGCA------CATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAT AAA---GCCAAATACTTACA----GCCAAC--TGATCTTT---GACAAA--GCAAA--CA AAAACATAA--AGTGG-----GGAAAGG----ACACC--------CTATT--CAACAAAT GGTGCTG----------G-GATAAT--TGG-C-AAGCCA---------------CATGT- AGA---------AGA--ATGAAACTGGATCCTC----ATCT---------------CTCA CC--TTATACAAAAA-TCAACT-CAAGATGGATCAAAGACTTAAATCTA--AGACCTGAA ACC-AT------------------------AAAAATTCTAGAA----------------- ------GATA--ACATC------A---------GAA---------AAACTCTTCTAGAC- --ATT-----GG-CTTAGGCAAAGAGTTCATGACCAA-GAACCCA-AAA----GCAAATG CAACAAAAACAAA----A------AT---AAAT--AGA-TGGGACCTA--AT-------- -------------------------------------------------------T-AAA CTAAAAAGCTT-CTGCA---CAGC-AAAAGAAATAATCAGC-AGAG-TAAACAG-ACAAC CCAC--AGAG--T-GGGAG--AAAATATTC---ACAAACTATGCAT--------CCGACA AAGGACTAA-------TATCCAGAATCTACA--AGGAA--CTCAA-----ACAAA----- ----------------------TCAGCAAGAA------AAAAAC------------A--- AATAATCCCA-TCAAAA----------AGTGGGCAAA-----------GGA--CATGAAT ---AGACAATTCTCAAAAGAAGATATACAAA--------------TGGCCAAC-AAACAT ATGAAAAAATG----CTCAACATCACTAA-TTATCAGGGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCACCTTACTCCTGCAAGAATGGCCA-- ----TAATTAAAA---AATCAAAAA-----------ATAATAG--ATG--TTGGC-A--- ---------------TGAATGTGGTGAA-------------------------------- -----AAGGGAACACTTTT-ACACTGCTGG--TGGGAA---------------------- -------------TGTA-------------AACTA-GTACAACC--------ACTATGG- -------AAAACA-GTATGGAG--ATTC-CTTAAAGAACTAAAA--GTAGAACTACCA-- -TTTGA--TCCAGCAATCCCACTACTGGG-TATCTA-CCCAGAGG-AAA--AGAA----- -------------------GTCATTAT-ATGAA--AAAGACACTTG----------C--- ---------ACACA--CATGTTTATAGCAGCACAATT---CACAATT-GCAAAATTAT-G GA--ACCA--GCCTAAA-TGCCCATCA---ACCAATG-----AGTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTATATAT----ACACCATGGAATAC--TACTCA-GCC ATAAAA----------------------AGGAATGAAATAATGGCATTT----------- ------------------------------------------------------------ -GCAGCAACCTGGATGGAG-T---T----------------GGAGACCATTATTCTAAGT GA-------------------------------------------------------AGT A----------------------------------------------------------- ----------ACTCA--GGAAT-------------------------------------- ------------------------------------------------------------ --------------------------------------------------GGAAAA---- -----------------------------CCAAATAT-CATATG--------TTC----- ------TCACT---TAT------------------------AAGTGGGAGC---CTAAGC T-------A--------------TGAGGA---------------T--------------- ------------------------------------GCAAA-------------GGCA-- -------TA-------------------------------------------AGAAT--- -GATATAATGGA---CTTTG-----GGGACTCG----------GGGGGA----------- ----AGGGTGGG------------------------------------------------ --AGG-------GGGGTG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGG------------GATAAAAGACTA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CACATTG---------------------------------------------- --------GGTA----CAGTGTAC----------------------ACTGCTCGGGT--G ATGGGT--------------------------------------GCACCAAA-------A TCT-----------------------------------------------------CAGA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AATCACCACT-- -------------------AAAGAACTTAT-----------------------CCATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACC------------------------------------------------------- ------AAAA-ACCACC-------------------------------TGTTCC------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------CCAAAAA----CTATTGAAA------TA- -------AAA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PB3 -------------------------------------AGATG--GCAGATT-GGAGGCAT TGCTAGCATGC---CTCTCCCA--------CTTGGAAAGAC------------------- ---------------------AAAA---------TAGTGTGTAGAGATT--------CAC AC--TGTGAACTT--------TTTTCCAAGAAGCAACGCAGGAA-----------CTTAA CAGG---AAAACTGAAAGA---------------A--------------ACCACAGACTC T--------------------TTGAAAGAAGCAG--TAGGCTGCAG-------------- ------------CCTACACTG-----------------TG--AGCCAGGCAAAAAACTG- ------------------------TGAGTC----CCCAGA----GTG-----TG-AGAGG GGGAGAG------------------------------ACTGCCT-TCAGGATAC-ACACC C-------------------------CCACCGGGGAACCTGAAAATCCAG----GCCACA GGGGAAGGCCTTAACCCT---ACC------------------------------------ ---C---------AGTGCTGGAACTGATTTAG------------------GGAGCAGTGG GGAATATAAAAGTAGGAGCAG---------CAGCGGGAAGAG------------------ ------------CCTTGTGTGCACTCCCAGTCTCCAGCATGGACCGAGG----------- ---------------------------GAAGCCATTCCTTATTCTACCTCACAGGGGACC TTGCGGAAGTCTG---------------------------------CCAGCTAACTCAGG CAGTGGTCACAGGT-TGAGAGAAGCTCCCAACTGAAATTCATGATA-------------- ---TAATCTCGAGTGGGGATAAACTCCCTTGGCCAGAACCGGGGGGT------------- ------------------------------------GAGTGGGAAGT------------- --------------------GTGCTGCAGCCATGGGCACAGGAGCTGGGCGCCCCGGCTT TGCGGGTAGACTGGGAGGGGCATGGCCTGAAAGCCATGGTTGCTGTCTCCGCCGGGAAGG CTTATGGCCTGGGGCAGTTTTGAGTTCTGAG----------TACAGGCTGCCTGGAACTT AGCTTGCTGCTGCTAGTGGAACACTGTGG--------------GTGTGAGATCTGCCTTG CCAAGTGCGTGGGAGCTGGGTGGGGCTTACTGCCGCCTGCTACTCCCCACTCCCTGTGCA AA-------------CTCTTCTGTGCAGCAGAGGCAGCTATGCTCCTCTCTGGAACATTA CCCCAGTGGCCTGAGAACCGCCCCCCGACCCCCACAGGGGCTGCTGCTT----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GCCCCGCATGTGGAGAGCCAGAGCGCAGACCTGCCTGACCC AGCCCCCACCTGGCTTTGCCCCTCCACCCGCCCTGGTAGCTTAACACAAAGGAC---AGA AACTTTTGGGAGCTTTATGGCCCCGCCCATTGCCTGAGAAACCAGAGTACCTCCCCTGGG TAACATAAGGCAAGCACAAATCCCACTGCTACTACCACAGCTGGTGCTCTTTTGCAAGCG CCACCTCCTGGCTGGAGGCCAACCAACACAGTCCATTATAGCATCTGCAGGTAGAATAAC ACTGCACCCAGGAAGGAGAAAACTTGTGCGTGACCTCAGCTATCACCATTGCCTGCACCA CGCT-------GGCTAACCAGGAGGTCCTGAGTCTGTCCATGTGACC------------A GTTCATTAC------TACTACA--ACTGGCATTTGAGAAAGCCAACACACTAAGGCTATT AATAATCTATAAATCTAAGAAAA--------------TTTCTAAAGTCCATCTCACCCCC CTG----------------------CCACCCCCACCAGAGCTGGTGCTGG---------- ------------TACCCACTGCTGGGAGACTTGAGAACAGGTCACATCACTGGATCCCTT GCAGACATTCC---CCAGCACCAGCCTGGAGTGTGGCAGCCCC---------------AC TGGGTGGCTA--GACTCAGAGGAGCAACAGCATTCACAGTAGTCTGGCTCTCAGGGACTC CTACTCCTAGGGGAAGGGGGAGT--------------GCACCACATCAAGGGAACACCCC ATGGGACAAAAGGAATCTGGATGGCAGGCCTTGAGTCCCAGA------------------ ------TCTTTCTACTGGTGGGAAGT---------------------------------- ----------------------------------------------TTCTTTCAGCAGAG GCACAGTTGCAGTGCTGGGCTCAGTGGGGAAAGTCTGAAGCTCTACCCCAACAGTCAGGC ATCCCTGGTGCTCATGAAGGGTCTTTTGGAGAAGGGGACGTCTTTTCCCCCTTGTCCACC ACTGCAGAC----------ACAGCTGGGGCTTTTCCCATGGGAGCTCAGCA--------- ------------TGGGTACACCT----------ATAGACAGCCTTTCTGGAACACTTCAG GGTGA-------------CTGCATCCCCACAGGAGGAGTACACTCCAGGTTCGGGCTTGC ATGAGAGGCAGAGTCACAATTCCTCTCTACTTGGAACATCAACATTCCTACAGATGAAAA G---AGGTGCTGGTCTGATCTGAAT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A GCCAGAATACTGGGTCAGGAGTGTGACTGGGAGGTGGATTGCTTTCCTGCTGGCCTGGCA GGGGAGCTGAGGTGGCTCCAACCCTTCCCCCTGATAAGACCTCAGTGTGTTTCACTGAGA GTTTCTCCACCTACCTCTGTCAAGGCTGGGACCTCTGCCCACTATTGGGTATTGCATTTA TCCACCTGCTTTAGCCACAACCAGTTTCTACCCAGGGACACCTCCCCTACTGGCCTGAAG CCTGAACTATTCAACCCATTAAAAAAATTACTGGGG---------------------AAA A-----------AATAAATATAAAAAAATATCCCCCAGGGAAGGAATGAGATAAGCTTCA AGAGACCTCTGCCATTCCAACCCCATAGGAGATAGTGAACTTGCTCACACACCAAGCACA TTGCTACTACAACCAGCATCTGAG---AAAGCCATCATACAAAGACTCTCTATTACC--- ------------------------------------------------------------ -----------AAGAAACTAGGAACTTATACAGAGAGTCTTCAC---------------- ----------CCCTGAAAGCACCAAGAGCCGAATTAGGCTATAATA-------------- --AACTATAA-ACATTAAA--GTCACATCCTTAAGGGGAACAATAAATTTAAAAACAAAC AGAAAAAAAAATTTTTAAAAAAAGTCAAATCAAAAATAAATTCAAGAATAATTAGAAGAA ATAGTCTACCCAAAAGAGAAGAAAAAAGAAAAATAATTGAGAAG---------------- ------GAACCAGA-------AAAATAATTCT-------GGCAATATGACAAAACAGGGT TCTATAACACCCC-----CAA------------AAGATCACACTAACTCT---------- CCAG---CAATGGATCCAA-------ACC-------AAGA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-AATCTTTG AAAT------ACCAGATA------AAGAA------------TTCAAAAG---GTTGAT-T ATTAAGT---TACTCAAGGAGAT----ACAAGAGAAAG---------------------- ------------------------------GTGAAAACCAACAT---AAAGAAAT----- ----------------------------------------T------------------- ----ACAAAAAAAATTCAGGATATG---AATAAAAAATT--------------------- ----------------------TTCTA-------------AAGA------GATAGATATT --------------------------------------TTAAAGAAAAAT---------- -----CAATCAGAAC--------------------------------------------- ------------------------TTCT-GGAAA---TGAAA---------GACAC---- -ATTTAGGGAA----TTACAAAATGCAGTGG-------AAAG------------------ --------------------------------------------TTTTAACAATAGACT- -----AGACC--AAGT------------------AGAAG---------AAAG-AAT-TTC AGAGCTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACAAGGCTTTTGAAT-T--AACCCAA------TCAG---------ACAA--- ------------------AAATAAAGAAAAA---AGA---ATAAAAAGAAA--------- TGA-ACAAAGTCTCCAA--GAAATATGGG-ATTATGTA-----------AAATG--GCCA AACCTAAGAA-TCATTGG--TGTTCCTGAGG-----------------GAGAAGAGAAAG CAAAAAGTTTGG---------AAAACTTATTTGA--G--------GGAATAATTGA-G-G AAAACTTCCCTGGCCT--------------------TGCTAGAGATTTAG--ACATCCAA ATAC-----AAGAAGCTCAAAGAAC---TCCTGG-GAGAT--------TCA--------- ---T-TGCAAAAA-----GAACATCACCAA----------------------------GG CATATAGTCATCAGGCT------ATC-TAAAG---------TCAATATGA---------- ------------AGG--AAAGAATTC---------------------------------- --------TAAGAGCAGTGAGACA---AAAGCATC--------------AGGTAAC---C TAT----------AAAG--------------GAAAACCTAT--CAGACTAA-C--AGCAG ACT--------TCTCAGCAGAA--ACCTTA-CAAG--CCAG-AAGGGATTG--------- ----GGG-TCCTATC-T-------TTAGCC--T-CCT-TAAACAGAAT------------ -AAC-TG--TCA--GCCAAGAA--------TTTTGT----------ATCCA--------- --GCAAAACTAAGT-----TTCA-TAAATGA-------AGG-AGAAATAAAGTCTTTTTC AGACAAGC-AAATGCTGAGGGA-ATTTGTCACTACCAGAC---CAGCCCTAC-AAGAAAT GCT--------------AAAAGG----------------------AGTTC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------CTTG---------------------- ------------------------------------------------------------ ----------------------------AAACAAA-----------AGGTCATTTTGAAC AAG---------AATAGAACCTC------TTGAAAGCAT------AAAA-----CTCACA ----GGGCCTATAAAACAATAAC----ACAA-------TGAAAAAAC-----ACAATAAA GAAAACAAAGTATCTAGGTAACAACTAAC---------------------------A--- ------------------------------------------------TGTGACT----- --------------------GGAACAG--TACC-TCACATCTCAATAT------------ -------------TAAC-ATTGAATG-TAAATGGCCT--AAATGC---TCCACTTAAAAG ATACAGAT--TGGCAGAA-TGGAT------------AAAAAATCACAAACCAAATA---- ---TCT-GCTGTCTTCAAGAG-ACTCACCT-AACAT--ATAAGGATTCATATAAACTCAA GG--TAAAGGGG--TGGAAAA-AGATATTCCATGCAAATGG------AAACC-------- -------------AAAAG-CAAGCAG--GAGTAGCTATTCTTATATC-AGATAAAACAGA CTTTAAA-GC----------AACAACAGTAAAAAAAGAC-AAAG-AAGGTCATTATAT-- ----AATGATAAA---AGGATCAATCCAAC--AAGAAG--------AT-ATTACAATCCT AA-----------------ATTTATATGCACCTAACACTGGAGCTCCCAG--ATTCATAA AACAATTACTACTAGACCTAAGAAATGAGATAGACAGCAACAC---------AATAATAG TGGGGGACTTCAACACTCCAC-----TGACAGCACTAGACAGA----------------- ----TCATCAAGAC------AGAA-----AGTCAACAAAGAAACAATGGACTTA------ --AACTACACTCTAGAACAAATGGAC-CTAACAG--ATATTTACAGAA--CATTCTACCC AAGAACTG---CAGAATATACATTCTTCTCA-------TCAGCACAT---GGAACATTCT C------CAAGATAGACCATATGATAGGCCACAAAACAAG-------------------- -TCTCAATAAATTTTAAAAAA--TCAAAAT----------------CATATCAA------ -GTATCTTCTCA---GACCACAGTGGAA-TAAAACTAGAAATCAACTCCA--------AA A-------------GG-AACCCTC---AAAACTATACAA----ATACATGGAAATTAAAC AATCTG-CTCCTGAA---TG-ATTTTTG--GGTTA---ACAATGAAAT--CAA-GATGGA AATTAAAAAATTCTTT---GAAAT------------------------GAATGATAATAG -TGACACAAG--TTATCAAAACCTC-TGG-GATACAGCAAAAGCAGTGCTAAGAGGAAAG --TTTATAGCACTAAATGCCTACATCAAAAAGT---CTGA--AAGATCA---CAAATTGA ------CAACCTAATGTCACACCTCAA---GGAACTAGAGAA---AC---AAGAACAAAC TAAACCCA-AAGCTAGCA------------GAAGAAAAGAAATAAC-AAAGATCAGAGCA GAACTA---AATGAAATTGAAACAAAAAAAA-------TACAAAAGATC-AATGAAACAA -AAAGT-------TGGTTCTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGATAGACCA---TTAGCTA------GATT-------------- AACCAAGAAAAGAAG---A---GAGA-AGATTCAAATAAG-------------------- -----CTCAA---T---------TAGAAATGAAACT------GGAGA---CATTACAACC A--------ACAC-CACAGAAATA-CAAAAGATC--ATTTA---------AGACT----- -------------------ACTATGAACAC-CTCTATGCACACAA--AC---TAGAAAAT CTAG---AGGAAAT--GGATAAATTCCT--G---GAAACA---------TAC-----AAC CCTCCT------AGATTAAATCAGGAAGAAATAGAAACCCTGAAC--------------- --------AGACCA------A------TAACAAGCAGTGAGAT----TGAAT--CAGTAA TTTAAAAAATTTCCAAAAAAAAAAAAAGCC-CAGGGCC--AGATGGATTCACAGCTGAA- TTCTA------------CCAGACATTC----AAAGAAGAATTGGTA-CCAATC-----C- ----TACTGAAACTATTCCAA-------AAGATTG-AGAAAGAGGG-----------AAT CCTCCCTAACTCATTCTATGAA---------GCCAGTAT---CACCCTGATACC--AAAA C-----------------------CAGGA--AAGGACA-TAAC----AA---------AA AAAGAAAACT---------------------ACA------GACCAATAT--CCC----TG ATGAACATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-TAACCA------------------AA--T------------ ---C-CA--ACA-------------GCACATC---------AAAAAGATAATACA--CCA ----TGAT------------CAAGTGGGT-TTCATCCCAGGGA-TGCAGG---------- -------------GATGGTTT-AAC-----ATATGC----AAGTCAATAAATGTG--ATA CATCAC---------A------TAAACAG----AATTAAAAACAAAAAC---CATATGA- ----TCATCTC---AATA----------GATGCAGA-AAAAG---CATTCAATAA---AA TCCAGCATCCCTT-------------------TATGA---------T-AAAAAC-CCTCA --ACAAACTAGGCATAGAAGGGACAT-----ACCTCAAAATAAT---------------- -----------AAAAGCCAT-ATAT-GACAAACCCACAGC-----------CAACAT--C ATACTGAATGGGGAAAA-G-----TTGAAAGC-ATTC---CCCCTGAGAA----CTGGAA CAAGACAAGGATGC-------CCACTTT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTTCTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATCAG------GCAAGAG---AAAGA--AATAAAGGGC ATCCAAATTGGAAA-------AGAGGAAGTCAAA--CTATCACTG-----TTTACCGATG AT--ATGATTGTA-------TACCTAGAAAACCCT---------------AAAGA---CT CCTCCA---------AAA--GACTCCTAGATTT---------GATAAA--TGAATTCAGT AAAG--TC-------------------------TCAGGTTACAA--------------AA TCAATGT------------ACACAAAT----CAGTAGCACTGC--TA-TACACCAA--CA ATGACCAAGCTGA------------------GAATCAAA-TCAAG----AACTCAATCCC TTTTACAATAGC-TGCAAA---AAAAATAAAATACCTAGGAATATACTT--------AAC -CAAGGAGGTGAAAGATCTCT---ACAAGGAG--AACTACAAAACACTGCTG-AAAGAAA TCATAGA-----------TG------------------ACAC--AAAC--AAATGGAAAC ACAT------C---CCATGCTCATG------GATTGGAAGAATC-----AATA-TTGTG- ------------------------AAAATGACCA-TA-CTGCCC-AA------------- ----AGCAATCTACAGA---TTCAATGCAATTCCTATCAAAAT---------ACCAACA- TC------------ATTTTT---------------------------------------- --CACAGAATTAG---AAA------AAACAATCCTAAAA-TTCATATGGAA-------CC AAAAAAGAGCCC---AA--ATAGCCAAAGCAATCCTAAGCAAAAAGAACA---AATC--T -------GGAGGCATCACA---TTACCAGACTTCAAATT-----ATACTACAA---GGCT ATAGT-TACCAAAAC-AG------CATGGTACTGG--TA-----------------TAAA AGTAGACA------CATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAT AAA---GCCAAATACTTACA----ACCAAC--TGATCTTT---GACAAA--GCATA--CA AAAACATAA--ATTGG-----GGAAAGG----ACACC--------CTATT--TAATAAAT GGTGCTG----------G-GAAAAC--TGG-C-TAGCCA---------------CATGT- AGA---------AGA--ATGAAACTGGATCCCT----ATCT---------------CTCA CC--TTATACAAAAA-TCAACT-CAAGATGGATCAAAGACTTAAATCTA--AGACCTGAA ACC-AT------------------------AAAAATTCTAGAA----------------- ------GATA--ACCTA------G---------GAA---------AAACTCTTCTGGAC- --ATT-----GG-CCTAGGCAAAGAATTTATGACTAA-GACCCCA-AAA----GCAAATG CAACAAAAACAAA----A------AT---AAAT--AAA-TGGGACCTA--AT-------- -------------------------------------------------------T-AAA CTAAAAAGCTT-CTGCA---CAGC-AAAAGAAATAATCATC-AGAG-TAAACAG-ACAAC CCAC--AGAA--T-GGGAG--AAAATATTT---GCAAACTATGCAT--------CTGACA AAGGACTAA-------TATCCAGAATCTACA--AGGAA--CTCAA-----ACAAA----- ----------------------TCAGCAAGAA------AAAA------------------ AATAATCCCA-TCAAAA----------AGTGGGCAAA-----------TGA--CATGAAT ---AGACATTTCTCAAAAGAAGATATACAAA--------------TGGCCAAC-AAACAT ATGAAAAAATG----CTCAACATCACTAA-TCATCAGGGA-AAT--GCAAATT-AAAACC ACAATGAGA---------------------TACCACCTTACTCCTGCAAGAATGGCCA-- ----TTATTAAAA---AGTCAAAAA-----------ACAATAG--ATG--TTGGC-A--- ---------------TGGATGTGGTGAA-------------------------------- -----AAGGGAATACTTAT-ACACTGCTGG--TGGGAA---------------------- -------------TGTA-------------AATTA-GTACAACC--------TCTATGG- -------AAAACA-GTATGGAG--ATTT-CTTAAAGAACTAAAA--GTAGATCTACCA-- -TTCGA--TCCAGCAATCCCACTACTGGG-TATCTA-CCCAAAGG-AAA--AGAA----- -------------------GTCATTAT-ATCAA--AAAGACACCTG----------C--- ---------ACACA--TATGTTTATTGCAGCACAATT---CACAATT-GCAAAGATAT-G GA--ACCA--ACCTAAG-TGCCCATCA---ACCAATG-----AGTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTATATAT----ACACCATGGAATAC--TACTCA-GCC ATAAAA----------------------AAGAATGAAATAATGTCTTTT----------- ------------------------------------------------------------ -GCAGCAACTTGGATGGAG-C---T----------------GGAGGCCATTATTCTAAGT GA-------------------------------------------------------AGT A----------------------------------------------------------- ----------ACTCA--GGAAT-------------------------------------- ------------------------------------------------------------ --------------------------------------------------GGAAAA---- -----------------------------CCAAATAC-CATATG--------TTC----- ------TCACT---TAT------------------------AAGTGGGAGCGAGCTAAGC T-------A--------------TGGGTA---------------T--------------- ------------------------------------GCAAA-------------GGCA-- -------TA------------------------------------------CAGAGT--- -GGTATAATGGA---CATTG-----GAGACCAGA---------AGGGGG----------- ---GAGGGTGGG------------------------------------------------ --AGG-------GGGGTG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGG------------GATAAAAAACTA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CATATTG---------------------------------------------- --------GGTA----CAATGTAC----------------------ACTACTCGGGT--G ACGGGT--------------------------------------GCACTAAA-------A TCT-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GACTTCACCA-- -------------------CTATACAATTCA--------T-------------CCATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACC-----AAAA---------------------------------------------- -----------ACCACT-------------------------------TGTACC------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------CCAAAAG----CTATTGAAA------TA- -------AAA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA15 --------------------------------AGCCAAGATG--GCTGACT-AGACGCAG CCAGGAGGAAC---ATCTCCCA--------CGGAGAGACTGG------------------ ---------------------GACA---------TCA--GGAAGACTGG--------CAC AC--TCTGAGCAG-A-----TCT-TCGGAGGGAAGGCATTGAGA-----------GTGGA TGGA---GGGAGGA-------------------------------------CACAGATGC T---------------------GGGCTGAAGGGGGAGGAAGC------------------ -------------------TG-----------------GG--AACCCTGCACGGGGCTAC TGAGCACC-----GGGACTCGTTCCTGGCC----CCCAGCAACTCCT-----GG-GGAAG GGGTGAGTTG---------------------------AGCAGGC-GAGGAGTGGCCCACT C-------------------------TCACCATGGACCTCCGGAATCCTG----GCAGCA GGAGA--CCCCACAACCC---CCC------------------------------------ ---C-GACACTTGAG--------CTGGCAGGG------------------AGAGCTGCTT AGAGAGGTGGTAGGGGCAGGA---------CTCCAGCCTGTGCGGAGCCCAGAGGG---- ------------TTTGGTGTGGGAATGTCTGCAGTGGAGCACGGC--------------- --------------------CAGGGATGCCCATCCCTCAA----GGCTCGCCATGCTCCT CTAGGAGACTTTA------------GCCTTAGGGT-----------GACTGTCAG----- -----ACCTGGACA-GAGCAGGGCGGTCTTGCCCATGAGATGGGGC-------------- ---CAGTCTGATCTGAGTGCCCCCCTGTCTGCTGGCCTCTCCCGGGG-----CCC----- ------------------------------------CAGCCTGGCCGCAC---------- -------------------CTGCTTGCAG-TGCAGCCTTGGATGCCCAA----------- -CCAGGGTGCCTCCTAGGGGC-------------------CCTCATCATAGCTCCTT--- -----------------------------------------CGCTGGCAGACCATGCCTG ACCAT--------------------CAGA--------------GAGCTCCAGCAGA---- -------------------GTGGCCCCCGCCGACG----------------TGCACCAG- -----------------CCCACCCGCATC----CCCTCC--------------------- -------CCCCCG---------------CAGCCTCCCCTGTGCCTCTTC----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------TCTGGCGTGCTCTCTCGC ACCCACTTTCCCCTGCCCCCCCCCCCATCGCTTT-----------------------GTT GGTGCGGG--T-------------------------------GGATGGGCGCA------- ----------------------CCTCCCCTCCCTTCCCCCACCAGCTTGTGTGTGTGCGT GCACCCGGCCACGCCACTGCTGCTGCCAGGA---TT------------------GGTCCC CACTGCCCTACCGCCTGACCATTGACAATCGGG------------------CACTTGGCA ATGCTGCCATTGCAAGCGGCAGCACCTGCATGGATGCCACAAACCTTGCTCCC------- CATTGTTCTTGAATGCACAATGATACAAACACAC------ACATGGA------------A CCCACCCCC------CCCCCCC----CCTGCCCCGTGCTGCCGCCGCTGCTGGCGC---- ---------GAATGCGCGCA-CG--------------GACGCCGGCAGCCCTGCCCCCCC CCG----------------------CCCCCTCCGCC--AGCTGCCACCGCCAGGGCGGCC GGCG--------CTGCCGTGC------CTCCCTGC---------------------ACGA AA-------CC---CT--CCCCC-----CC-----GCCCCACC---------------CC CTTCTTGCCC--CCACCGCCGGCGTAAGCACATGCAGGAATGCT-GCAG----------- -----------C-------------------------CCTACTCCT-------------- -----GCTGGTACCCCGCCCCAGCCGACG-------CGCGTG------------------ ------CACCCCGCTGCGCTG--------------------------------------- -----------------------------------------------CCACGGCTGCTGG CATGCACGAGTGAGCACGGAT--CCCG----------------------------CTGCC ACC--------------------A------------------CCCCGATGAAGT--TTTG GCCGGCACC----------A-------GAGTGTT----------GTGGCCA--------- ------------GCGGACTGGGA------------------ACACCTCGGCCC---CTCC ----A-------------GTGC----------GCAG------------------------ -------------------------------------------GTTCCTAACCTCGAG-- -----------GGGCCAGAGAACAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AGCCGGGGGCCCGGTACCAGCCCCCCAGAG TTAGAGCATGCAGCCCAGGAGTGCTGAGCTGAGCCTTGGCCCCCTAAAATCTTCCA---- ------------------------------------------------------------ --------------------GAAACGA------------------------------AGC C-----------AGTTGACTGAACCCACCTTATACC------------------------ ------------------------------------------------------------ -----ACAATCAAACCCCCAAGGG--------CATCAAAGAAGATAAAAGCAAAAAAAAA AACAAAAAAA-------------------------------------------------- -----------AAAAAACC----------------------CAT---------------- -----------CCAAAGGACAGC------------------------------------- --AACTTC---AGATTGAA--------------G-------------------------- ---GAACATCA------GCCC--------------------------------------- ------------------------AC-------ACAG-----AA---------------- ------GAACCAGT-------GCAAGAACTCT-------GGCAACTCAAAAAGCCAGAGT GTCTTCTTACCTC-----CAA------------ACGACTGCACTAGTTCC---------- CCAG---CAATGGTTCTTA-------ACC-------AGGC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-AATGGCTG AAAT------GACAGAAA------TAGAA------------TTCAGAAT---ATGGAT-A GGAATGA---AGATCATTGAGAT----TCAGGAGAAAG---------------------- ------------------------------TTAAAACCCAATCC---AAGGAATC----- ----------------------------------------T------------------- -------AAGGAATACAATAAAATG---ATACAGGAGCT--------------------- ----------------------GAAAG-------------ATGA------AATGGCCATT --------------------------------------TTAAGAAAGAAC---------- -----CAAACTGATC--------------------------------------------- ------------------------TGAT-AGAGC---TGAAA---------AACTC---- -ACTACAAGAA----TTTCATAATACAATCA-------CAAG------------------ --------------------------------------------TATTAACAGCAGAAT- -----AGACC--AAGC------------------TGAGG---------AAAG-AAT-CTC AGAGCTC----------------------------------------------------- ------------------------------------------------------------ ----AAAGACTGGTTCTCTGAAA-T--AACTCAG------TCAG---------ACAA--- ------------------AAATAAAGAAAAA---AAA---ATAAAAAAGAA--------- TGA-ACAAAACCTCCAA--GAAATATGGG-ATTATGTA-----------AAGAG--ACCA AATCTATGAC-TCATTGG--CATCCCTGAAA--------------GAGAGGGAGAGAAAG CAAGCAACTTGG---------AAAACATATTTGA--G--------GATATCATCCA-T-G AAAATTTCCCCAACCT--------------------CACTAGAGAGGCCA--ACATTCAA ATTC-----AGGAAATGCAGAGAAC---CCCTGT-GAGAT--------ACT--------- ---A-TACAAGAA-----GACCATCCCCAA----------------------------GA CACATAGTCATCAGATT------CTC-CAAGG---------TTAAAATGA---------- ------------AAA--AAAAAATGT---------------------------------- --------TAAAGGCAGCTAGAGA---GAAGGGGC--------------AGGTCAC---C TAC----------AAAG--------------GGAACCCCAT--CAGGCTAA-C--AGCAG ACC--------TTTCAGCAGAA--ACCCTA-CAAG--CCAG-AAGAGATTG--------- ----GGG-GCCTATA-T-------TCAGCA--T-TCT-TAAAGAAAAG------------ -AAA-TT--CCA--ACCAAGAA--------TTTCAT----------ATCCA--------- --GCCAAACTAAGC-----TTCA-TAAGCAA-------AGG-AGAAATAAGATCCTTTTC AGACAAGC-AAATGCTAAGGGA-ATTCATTACCACCAGAC---CTGCCTTAC-AAGAGGT CCT--------------TAAGGG----------------------AGTGC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------AGACCATTACCAGC CACCAC------AAAAACACACT------T---------------TAAG-----TACATA ----GA------CCATTGACACT----ATAA-------AGCAACCAC-----ACAATCAA GTCTGCATAATAACCAGCTAACAAC-------------------------------A--- ------------------------------------------------TGTGACA----- --------------------GGATCAA--ATCT-GCACATATCAATAT------------ -------------TAAC-CTTGAATG-TAAATGGGCT--AAATGC---CCCAATTAAAAG GCACAGAG--TGGCAAGT-TGGAT------------AAAGAAGCAAGACCCAACTG---- ---TAT-GCTGTCTTCAAGAG-ACCCATCT-CACAT--GCAATGACACCCATAGGCTCAA AG--TAAAGGGA--TGGAGAA-AAATCTACCAAGCAAATAG------AAAAC-------- -------------AGAAA-AAAGCAG--GGGTTGCTATTCTAATTTC-AGACAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAAAGAC-AAAG-AAGGGCATTACAT-- ----AATGGTAAA---GGGTTCAATTCAAC--AAGAAG--------AC-CTAACTATCCT AA-----------------ATATATATGCACCCAACACAGGAGCACCCAG--ATTCATAA AGCAAGTTCTTAGAGACCTACAAAGAGACTTAGATAACCACAC---------AATAATAG TGGGAGACTTCAACACCCCAC-----TGACAGTATTAGACAGA----------------- ----TCATTGAGGC------AGAA-----AACTAACAAAGATATTCAGGACCTG------ --AACTCGACACTTGACCAAATGGAC-CTAACAG--ACATCTACAGAA--CTCTCCACCC AAAAACAA---CAGAATATACATTCTTCTCA-------TCTGCACAT---GGCACATACT C------TAAAATTAACCACACAATCGGCCATAAAACAAT-------------------- -CCTCAGCAAATTCAAAAAAA--CTGAAAT----------------CATACCAA------ -CCACACTCTCA---GACCACAGCACAA-TAAAAATAGAAATCAATACTA--------AG A-------------AA-ATCGCTC---AAAACCATACAA----TTACATGGAAATTAAAC AACCTG-CTCCTGAA---TG-ACTTTTG--GGTAA---ACAATGAAAT--TAA-GGCAGA AATCAAGAAATTCTTT---GAAAC------------------------TAATGAGAACAA -AGATACAAC--ATACCAGAATCTC-TGG-GACACAGCTAAAGCAGTGTTAAGAGGGAAG --TTTATAGCACTAAACACCCACATCAAAAAGT---TAGA--AAGATCT---CAAATTAA ------CAACCTAACATCACACCTAGA---GGAACTAGAAAA---AC---AAGAGCAAAC CAACCCCA-AAGCTAGCA------------GAAGACAAGAAATAAC-CAAAATCAGAGCT GAACTG---AAGGAAATTGAGATGCAAAAAA-CCA---TACAAAAGATC-AATGAATCCA -GGAGT-------TGGTTTTTTGAAAGAATAAA--------------------------- -----------------------------------------------------------T AA-----GA------TTGATAGACCA---CTAGCTA------GACT-------------- AATAAAGAAAAAAAG---A---GAGA-AGATCCAAATAAA-------------------- -----CACAA---T---------CAGAAATGACAAA------GGGGA---CATTACCACT G--------ACCC-CACAGAAATA-CAAAAAACC--CTCAG---------AGACT----- -------------------ACTATGAACAC-CTCTATGCACACAA--AC---TAGAAAAC CTAG---AAGAAAT--GGATAAATTCCT--G---GAAACA---------TAC-----AAC CTCCCA------AGATTGAACCAGGAAGAAATTGAATCCCTGAAC--------------- --------AGACCA------A------TAATGAGTTCTAAAAT----TGAAT--CAGTAA -TAAAAAGCCTACCAACCAGAAAAAG--CC-CAGGACC--AGATGGATTCACAGCTAAA- TTCTA------------CCAGATGTAT----AAAGAAGAGCTGGTA-CCATTC-----C- ----TACTGAAACTATTCCAA-------AAAATTG-AGGAGGAGGG-----------ACT CCTCCCTAACTCATTCTATGAG---------GCCAGCAT---CATCCTGATACC--AAAA C-----------------------CTGGC--AGAGACA-CAAC----AA---------AA AAAGAAAACT---------------------TCA------GGCCAATAT--CCT----TG ATGAACATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACCG------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGCTAATCCA--CCA ----CGAT------------CAAGTAGGC-TTTATCCCTGGGA-TGCAAG---------- -------------GTTGGTTC-AAC-----ATATGC----AAATCAATAAATGTG--ATT CATCAC---------A------TAAACAG----AACTAAAAACAAAAAC---CACATGA- ----TCATCTC---AATA----------GATGCAGA-AAAGG---CTTTTAATAA---AA TTCAACATCCCTT-------------------CATGT---------T-AAAAAC-CCTCA --ACAAACTAGGCATTGAAGGAACAT-----ACTTCAAAATAAT---------------- -----------AAGAGCCAT-CTAT-GACAAACCCACAGC-----------CAACAT--C ATACTGAATGGGCAAAA-G-----CTGGAAGC-ATTC---CCCTTGAGAA----CCAGAA CAAGACAAGGATGC-------CCACTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATCAG------GCAAGAG---AAAGA--AATAAAAGGC ATCCAAATAGGAAG-------AGAGGAAGTCAAA--CTATCTCTG-----TTTGCAGATG AT--ATGATTCTA-------TACCTAGAAAACCCC---------------ATAGT---CT CTGCCC---------AAA--AGCTCCTAGATCT---------GATAAA--CAACTTCAGC AAAG--TT-------------------------TCAGGATACAA--------------AA TCAATGT------------ACAAAAAT----CAGTAGCATTTC--TA-TACACCAA--CA ACATCCAAGCTGA------------------GAGCCAAA-TCAAG----AATACAATCCC ATTCACAATAGC-CACAAA---AAGAATAAAATACCTAGGAATACAGCT--------AAC -CAGGGAGGTGAAAGATCTCT---ACAATGAG--AATTACAAAACACTGCTC-AAAGAAA TCAGAGA-----------TG------------------ACAC--AAAC--AAATGGAAAA ACAT------T---CCATGCTCATG------GATAGGAAGAATC-----AATA-TTGTT- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----AGCAATTTACAGA---TTCAATGCTATTCCTATCAAACT---------ACCAATG- AC------------ATTCTT---------------------------------------- --CACAGAATTAGA--AAA------AAACTATTTTAAAA-TTCATATGGAA-------CC AAAAAAGAGCCT---AA--ATAGCCAAGGCAATCCTAAGCAAAAA-AACA---AAGC--T -------GGAGGCATCACA---TTACCTGACTTCAAACT-----ATACTACAA---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CAAA AACAGACA------CATAGAC--CAATGGAACAGAATAGAGAGCCC------AG--AAAT AAA---GCCACACACCTACA----ACCATC--TGATCTTT---GACAAA--GTTGA--CA AAAACAAGC--AATGG-----GGAAAGG----ACTCC--------CTATT--CAATAAAT GGTGCTG----------G-GATAAC--TGG-C-TAGCCA---------------TATGC- AGA---------AGA--TTGAAACTGGACCCCT----TCCT---------------TACA CC--ATATACAAAAA-TCAACT-CAAGATGGATTAAAGACTTAAATGTA--AAACCTAAA ACT-AT------------------------AAAAACCCTGGAA----------------- ------GATA--ACCTA------G---------GAA---------ATACCATTCTGGAC- --ATA-----GG-CCCTGGCAAAGATTTCATGATGAA-GATGCCA-AAA----GCAATTG CAACAAAAACAAA----A------AT---TGAC--AAA-TGGGACCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTATCAAC-AGAG-TAAACAG-ACAAC CTAC--AGAA--T-GGGAG--AAAATATTT---GCAAACTATGCAT--------CTGACA AAGGTCTAA-------TATCCAGAATCTATA--AGGAA--CTTAA-----ACAAA----- ----------------------TTAACAAGCA------AAAAAC------------A--- AACAACCCCA-TTAAAA----------AGTGGGCAAA-----------GGA--CATGAAC ---AGACACTTTTCAAAAGAAGACATACATG--------------TGGCCAAC-AAGCAT ATGAAAAAATG----CTCAACATCACTAA-TCATTAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACACCAGTCAGAATGGCTA-- ----TTATTAAAA---AGTCAAAAA-----------ATAACAG--ATG--CTGGC-G--- ---------------AGGTTGTAGAGAA-------------------------------- -----AAGGGAATGCTTAT-ACACTGCTGG--TGGGAA---------------------- -------------TGTA-------------AATTA-GTTCAGCC--------ATTGTGG- -------AAAGCA-GTTTGGGA--ATTT-CTCAAAGAACTAAAA--ACAGAACTACCA-- -TTTGA--CCCAGCAATCCCATTATTGGG-TATATA-CCCAAAGG-AAT--ATAA----- -------------------ATCATTCT-ACCAT--AAAGACACATG----------C--- ---------ATGCG--TATGTTCATTGCAGCACTATT---CACAATA-GCAAAGACAT-G GA--ATCA--ACCTAAA-TGCCCATCA---ATGGTAG-----ACTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AAGAATGAGATCATGTCCTTT----------- ------------------------------------------------------------ -GCAGCAACATGGATGGAG-C---T----------------GGAGGCCATTATCCTAAGT GA-------------------------------------------------------ACT A----------------------------------------------------------- ----------ACGCA--GGAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAA---- -----------------------------CCAAATAC-TGCATG--------TTC----- ------TCACT---TAT------------------------AAGTGGGAGC---CTAAAC A-------T--------------TGAGTA---------------C--------------- ------------------------------------ACATG-------------GACA-- -------CA------------------------------------------AAGAAG--- -GGAACAACAGA---CACCG-----GGGCCTACT---------TGAGGG----------- TGG-AGGGTGGG------------------------------------------------ --A-G-------AGGGTG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGG----------ATCG--AAAAACTA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CCTATCG---------------------------------------------- --------GGTA----CTATGCTT----------------------ATTACCTGGGT--- --GAAA--------------------------------------TAATCTGT-------A CAC-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCCCCGTG-- -------------------ACATGCAATTTA--------C-------------CTATA-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA-----AACC---------------------------------------------- -----------TGCACA-------------------------------TGTACC------ ------------------------------------------------------------ -------------------------------------------------CCT-------- --------------GAACC------------TAAAATA----AAAGTTAAA------AA- -------AAAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA13 ---------------------------GGAGAGGGCAAGATG--GCCGACT-AGATGCAG CCAGGTGGAAC---AGCTCCCA--------CTGAG-----GG------------------ ------------------------A---------CTG--AGATGACTGG--------CGT GC--TCCTAACAG-A-----TCT-TCAGAGGGAAGGCACTGAGA-----------GTGGA CGGA---GGGAAGA-------------------------------------CACAGAAGC T---------------------GGGCTGAAGGGGGAGAAAGC------------------ -------------------TG-----------------GG--AACCCTGCATGGGGCTAC TGCGCACC-----GGGACTCATTCCTGGCC----CCCAACGGCTCCG-----GG-GGAAT GGGTGAGTTG---------------------------AACTGGC-AAGGAGCAACCTGCT C-------------------------TCACCATGGGCCTCTGGAACCCCG----GCAGGA GGAGA--CCCCTCGACCA---CCA------------------------------------ ---CAGACACTTGAG--------TTGGCAGGG------------------AGAGCTGCTT AGAGAAGTGGTAGGGGCAGCA---------AGCCAGCTGATGTGGAGCCCAGAGGG---- ------------TTTGGTGCGGGAGCATCTGTAGTGGAGCATGGC--------------- --------------------CAGGGACGGCCATCCCCCTA----GGCTCGACTTGCTCCC ATAGGAGACTTTA------------GCCCTAGGGG-----------AACTGTCGG----- -----ACCTGAACT-CTGCAGGGCGGTCTTGCCCATCAGATGGGGC-------------- ---TGGTCTGACCTGAGCACCCCTTGGTCTGCTGGCCTCTCCTGGGG-----CCC----- ------------------------------------CAGCCTGGCCATGC---------- -------------------CTGCTTGCAG-GGCAG-T----------------------- -CTCGGGTGC--CCTGGGGGC-------------------CCACACCATAGCTTCTG--- -----------------------------------------CGCTGGCGGACCATGCCTG ACCAG--------------------TGGA--------------GAGCTCCAGCAGG---- -------------------GCAGCCCCTATGGCCA----------------CGCACCAG- -----------------CCTGCATGCTCC----CTCCCC--------------------- -------ATACTG---------------CAGCTTCCCCCGGG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------C-- ---------CCATGGCAACTCCCCACATCACTTT-----------------------GCT GGTGTGTGTCT-------------------------------GCACGGGCGGG------- ----------------------TTTTGCTTTCCTTGCCCCGCCAGCA------------- --------------------TGCGGGAGTGCAGTCC------------------GCCCCC CCCCCCCCCGCCGACCA-CCATTGCAGACGGAG------------------CCTT----- -----------------GGTGG-----GCACAGAGCCAGCCAGCCCCG-CCCCACCAGTG CCCTGCCCTTGCGCTAACACT-------------------GCACAGA------------G AACAGCGGA------TCCTCCC----CC-ACCCTGAGCGACCACTCCTGCTTG------- ------------CGGGCACAGAG--------------AAGGCACCCAGACCTGTGCCTGC CAG----------------------CACCCCCCCCCCGAGCCAACACCACCT------CC AGTG--------TGACTGCGCACACAGTCTCCAGC---------------------AGGG GC-------CC---CCTTCCCCC-----CC-----CCCCCCCA---------------GC TGCATTGCCT--CTGCCACTGTGGTGAATGCCCGCAGGGAGGCAGGCAC----------- -----------C-------------------------CCGGCACCC-------------- -----GCTAGCACTCTGCTGCAGCTGCTG-------ATCGTG------------------ ------CACCCCACTCCGCTGCTGCT---------------------------------- ----------------------------------------------ACCACTGCTGCTGG CACGTGCGAATGAGGATGGAT--CCCG----------------------------CTGTC ACC--------------------G------------------CACT-ACGAAATGCTTTG GCTGACACC----------ACCCATCGGAGTGTA----------GTGACCA--------- ------------GCGGTCTGGGAGATCTCCATTGTCCAGGCGCCCCTCGGCCC---CCCC ----A-------------GCGCA---------GTGG------------------------ -------------------------------------------ATTCCTAACCTCGAG-- -----------GAGCCAGAGAACAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AGTC-GGGGCCCAATACAAGTCCCCCAGAG TTAGAGCACGCAGTCCAGGAGTTGGGAGCTGAGCGTTGGCCCCCTAAAATCTTCCA---- ------------------------------------------------------------ --------------------GAAATGA------------------------------AGC C-----------AGTCAGCTGAATCCACCTTATACC------------------------ ------------------------------------------------------------ -----ACAATCAAACCCTCAAGGT--------CATCAAATAGGATA-------------- ---AAAAAAA-------------------------------------------------- -----------AAAAAAAA----------------------CAT---------------- -----------CCAAAGGTCAGC------------------------------------- --AACCTCAA-AGATTGAA--------------G-------------------------- ---GTAGATAA------GCCC--------------------------------------- ------------------------AC-------AAAGTGAGAAA---------------- ------GAATCAGC-------ACAAGAACCCT-------GACAACTCAAAAAGCCAGAGT GCCTTCTTTCCTC-----CAA------------ATGACCGCATCACCTCT---------- CCAG---CAAGGGTTCTGA-------ACC-------AGGC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-GATGGCTG AAAT------GACAGAAA------TAGAA------------TTCAGAAT---ATGGAT-A GGAACGA---AGATCATTGAGCT----ACAGGAGTACA---------------------- ------------------------------TTGAAACCCAATCC---AAGGAAGC----- ----------------------------------------T------------------- -------AAAAATCATGATAAAACA---ATGCAGGAGCT--------------------- ----------------------GACAG-------------ACAA------AATAGCCAGT --------------------------------------ATAGAAAAGAAT---------- -----GTAACCAACC--------------------------------------------- ------------------------TGAT-AGAGC---TGAAA---------AACAC---- -ACTACAAGAA----TTTCATAATGCAATCA-------CAAG------------------ --------------------------------------------TATTAATAGCAGAAT- -----AGACC--AAGC------------------AGAGG---------AAAG-AAT-CTC AGAGCTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACTGGCTTTCTGAAA-T--AAGACAG------TCAG---------ACAA--- ------------------GAATAGAGAAAAA---AGA---ATGAAAAGGAA--------- TGA-ACAAAACCTCCGA--GAAATATGGG-ATTATGTA-----------AAGAG--ACCA AATCTATGAC-TCATTGG--TGTCCCTGAAA--------------GAGATGGGGAGAATG GAACCAACTTGG---------AAAACATATTTCA--G--------GATATCATCCA-T-G AGAACTTCCCCAACCT--------------------AGCTAGAGAGGCCA--ACATTCAA ATTC-----AGGAAATGCAGAGAAC---CCCAGT-AAGAT--------ACT--------- ---T-CACAAGAA-----GATCATCCCCAA----------------------------GA CACATAATCATCAGATT------CTC-CAAGG---------TCGAAATGA---------- ------------AAG--AAAAAATGT---------------------------------- --------TAAAGGCAGCTAGAGA---GAAAGGTC--------------AGGTCAC---C TAC----------AAAG--------------GGAAGCCCAT--CAGACTAA-C--AGCAG ACC--------TCTCAGCAGAA--ACCCTA-CAAG--CCAG-AAGAGATTG--------- ----GGG-GCCAATA-T-------TCAACA--T-TCT-TAAAGAAAAG------------ -AAA-TT--CCA--ACCCAGAA--------TTTCAT----------ATCTG--------- --GCCAAACTAAGC-----TTCA-TAAGCGA-------AGG-AGAAATAAGATCCTTTTC AGACAAGC-AAATGCTGAGGGA-ATTTGTTACCACCAGAC---CTGCCTTAC-AAGAGCT CCT--------------GAAGGA----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------AGACCATTACCAGC CACTAC------AAAAACACACT------G---------------AAGT-----AACACA ----GA------CCAGTGACACT----ATAA-------AGCAACCAC-----ATAAACAA GTCTGCAAAATAACCAGCTAACATC-------------------------------A--- ------------------------------------------------TGTGACA----- --------------------GGATCAA--ATCC-ACACATATCAATAC------------ -------------TAAC-CTTGAATG-TAAATGGGCT--AAATGC---CCCAATTAAAAG ACACAGAG--TGGCAAGC-TGGAT------------AAAGAACCAAGACCCATTGG---- ---TAT-GCTGTCTTCAAGAG-ACCCATCT-CACAT--GCAATGACACACATAGGCTCAA AA--TAAAGGGA--TGGAGAA-AAATCTACCAAGCAAATGG------AAAAC-------- -------------AGAAA-AAAGCAG--GGGTTGCAATCCTAGTTTC-AGACAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAAAGAC-AAAG-AAGGGCATTACAT-- ----AATGGTAAA---GGGTTCAATTCAAC--AAGAAG--------AT-CTAACTATCCT AA-----------------ATATATATGCACCCAACACAGGAGCACCCAG--ATTCATAA AGCAAGTTCTTAGAGACCTTCAAAGAGACTTAGACTCCCACAC---------AATAATAG TGGGAGACTTTAACACCCCAC-----TGACAATATTAGACAGA----------------- ----TCATTGAGAC------AGAA-----AATTAACAAAGATATTCAGGACCTG------ --AACTCAGCACTGGATCAAATGGAC-CTGATAG--ACATCTACAGAA--CTCTCCACCC AAAAACAA---CAGAATATACATTCTTCTCA-------TTGCCACAT---GGCACATACT C------TAAAATTGATCACATAATCGGAAGTAAAACACT-------------------- -CCTCAGCAAATGCAAAAGAA--CTGAAAT----------------CATAACAA------ -AC---CTCTCA---GACCACAGCACAA-TCAAATTAGAAATCAAGACTA--------AG A-------------AA-TTCACTC---AAAACCATACAA----TTACATGGAAATTGAAT AACCTG-CTCCTGAA---TG-ACTTTTG--GGTAA---ATAATGAAAT--TAA-GGCAGA AATCAAGAAGTTCTTT---GAAAC------------------------TAATGAGAACAA -AGATACAAC--ATACCAGAATCTC-TGG-GACACAGCTAAGGCAGTGTTAAGAGGGAAA --TTTATAGCACTAAATGCCCACATCAAAAAGT---TAGA--AAGATCT---CAAGTTAA ------CAACCTAACATCACAACTAAA---AGAACTAGAGAA---CC---AAGAGCAAAC AAATCCCA-AAGCTAGCA------------GAAGACAAGAAATAAC-CAAAATCAGAGCT GAACTG---AAGGAGATTGAGACACAAAAAA-CCA---TTCAAAAGATC-AATAAATCCA -GGAGC-------TGTTTTTTTGAAAAAATTAA--------------------------- -----------------------------------------------------------T AA-----AA------TAGATAGACCA---CTAGCTA------GACT-------------- AATAAAGAAGAAAAG---A---GAGA-AGATTCAAATAAA-------------------- -----CACAA---T---------CAGAAATGACAAG------GGGGA---TATTACCACT G--------ACCC-CACAGAAATA-CAAACAACC--ATCAG---------AGAAT----- -------------------ATTATGAACAC-CTCTATGCACATAA--AC---TAGAAAAT CTAG---AAGAAAT--GGATAAATTCCT--G---GACACA---------TAC-----ACC CTCCCA------AGACTGAACCAGGAAGAAATTGAATCCCTGAAC--------------- --------AGACCA------A------TAATGAGCTCTGAAAT----TGAGT--CAGTAA -TAAATAGCCTACCAACCAAAAAAAG--CC-CAGGACC--AGATGGATTCACAGCTGAA- TTCTA------------CCAGATGTAC----AAAGAAGAGCTGGTA-CCATTC-----C- ----TGCTGAAACTATTCCAA-------AAAATTG-AGGAGGAGGG-----------ACT CCTCCCTAACTCATTCTATGAG---------GCCAGCAT---CATCCTGATACC--AAAA C-----------------------CTGGC--AGAGACA-CAAC----AA---------AA AAAGAAAACT---------------------TCA------GGCCAATAT--CCT----TG ATGAACATTGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTGGC-AAACCG------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGCTTATCCA--CCA ----TGAT------------CAAGTAGGC-TTTATCCCTGGGA-TGCAAG---------- -------------GTTGGTTC-AAC-----ATATGC----AAATCAATAAATGTG--ATT CATCAC---------A------TAAACAG----AACTAAAGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAGG---CTTTTGATAA---AA TTCAACACCCCTT-------------------CATGT---------T-AAAAAC-TCTCA --ATAAACTAGGTATTGAAGGAACAT-----ACCTCAAAATAAT---------------- -----------AAGAGCCAT-CTAT-GACAAACCCACAGC-----------CAACAT--C ATACTGAATGGGCAAAA-G-----CTGGAAGC-ATTC---CCCTTGAAAA----CCGGCA CAAGACAAGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTATT---GGAAG TCCTGGCCAG--------GGCAATCAG------GCAAGAG---AAAGA--AATAAAGGGC ATCCAAATAGGAAG-------AGAGGAAGTCAAA--CTATCCCTG-----TTTGCAGATG AC--ATGATCCTA-------TATCTAGAAAACCCC---------------ATAGT---CT CAGCCC---------AAA--AGCTCCTTAAGCT---------GATAAA--CAACTTCAGC AAAG--TC-------------------------TCAGGATACAA--------------AA TCAATGT------------GCAAAAAT----CACTAGCATTCC--TA-TACACCAA--CA ACAGTCAAGCCGA------------------GAGCCAAA-TCAGG----AATGCAATCCC ATTCACAATTGC-CACAAA---AAGAATAAAATACCTAGGAATACAGCT--------AAC -CAGGGAGGTGAAAGATCTCT---ACAAGGAG--AACTACAAAACACTGCTC-AAAGAAA TCAGAGA-----------TG------------------ACAC--AAAC--AAATGGAAAA ACAT------T---CCATGCTCATG------GATAGGAAGAATC-----AATA-TTGTT- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----AGCAATTTATAGA---TTCAATGCTATTCCTATTAAACT---------ACCATTG- AC------------ATTCTT---------------------------------------- --CACAGAACTAG---AAA------AAACTATTTTAAAA-TTCATATGGAA-------CC AAAAAAGAGCCC---GA--ATAGCCAAGGCAATCCTAAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACG---CTACCTGACTTCAAACT-----ATACTACAG---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CAAA AACAGACA------CATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAT AAG---GCCACACACCTACA----ACTATC--TGATCTTT---GACAAA--CCTGA--CA AAAACAAGC--AATGG-----GGAAAGG----ATTCC--------CTATT--CAATAAAT GGTGCTG----------G-GATAAC--TGG-C-TAGCCA---------------TATGC- AGA---------AGA--TTGAAACTGGACCCCT----TCCT---------------TACA CC--ATATACAAAAA-TTAACT-CAAGATGGATTAAAGACTTAAATGTA--AAACCCAAA ACT-AT------------------------AAAAACCCTGGAA----------------- ------GACA--ACCTA------G---------GCA---------ATACCATTCTGGAC- --ATA-----GG-AACGGGCAAAGATTTCATGACAAA-GACACCA-AAA----GCAATTG CAACAAAAGCAAA----A------AT---TGAC--AAA-TGGGATCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTATCAAC-AGAG-TAAACAG-ACAAC CTAC--AGAA--T-GGGAG--AAAATTTTT---GCAAACTATGCAT--------CTGACA AAGGTCTAA-------TATCCAGCATCTATA--AGGAA--CTTAA-----ACAAA----- ----------------------TTTACAAGAA------AAA---------------A--- AACAACCCCA-TTAAAA----------AGTGGGCAAA-----------GGA--CATGAAC ---AGACACTTTTCAAAAGAAGACATACATG--------------TGGCCAAC-AATCAT ATGAAAAAAAG----CTCAACATCACTGA-TCATTAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACACCAGTCAGAATGGCTA-- ----TTATTAAAA---AGTCAAAAA-----------ATAACAG--ATG--CTGGG-A--- ---------------AGGTTGTGGAGAA-------------------------------- -----AAAGGAAAACTTAT-ACACTGTTGG--TGGGAG---------------------- -------------TGTA-------------AATTA-GTTCAACC--------ATTGTGG- -------AAGACA-GTGTGGCA--ATTC-CTCAAAGACCTAAAA--ACAGAAATACCA-- -TTTGA--CCCAGCAATCCCATTACTGGG-TATATA-CCCAAAGG-AAT--ATAA----- -------------------ATCATTCT-ATTAT--AAAGACACATG----------C--- ---------ACATG--TATGTTCATTGCAGCACTATT---CACAATA-GCAAAGACAT-G GA--ATCA--ACCTAAA-TGCCCATCA---ATGGTAG-----ACTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AAGAATGAGATCATGTCCTTT----------- ------------------------------------------------------------ -GCAGGAACATGGATGGAG-C---T----------------GGAGGCCATTATCCTTAGC AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------ATGCA--GGAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAA---- -----------------------------CCAAATAC-CGCATG--------TTC----- ------TCACT---TAT------------------------AAGTGGG------CTAAAT G-------A--------------TGAGAA---------------C--------------- ------------------------------------ACATG-------------GACA-- -------CA------------------------------------------TAGAGG--- -GGAACAACACA---CACTG-----GGGCCTATT---------GGAGGG----------- TGG-AGGGTGGG------------------------------------------------ --AGG-------AGGGAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGG----------ATCAG-GAAAAATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ACTAATG---------------------------------------------- --------GGTA----CTAGGCTT----------------------AATACCTGGGT--G ATGAAA--------------------------------------TAATCTGT-------A CAA-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCCCCATG-- -------------------ACACA-AGTTTA--------C-------------CTATA-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA-----AACC---------------------------------------------- -----------TGCACA-------------------------------TGTACC------ ------------------------------------------------------------ -------------------------------------------------CCT-------- --------------GAACT------------TAAAATA----AAAGTAAAA------TA- -------AA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PREC2 ------------------------------------AAGATG--GCTGACT-AGACGCAG CCAGGAGGAAC---ATCTCCCA--------CCGAC-----GG------------------ ---------------------GACA---------TCG--GGAAGACTGG--------CGC AC--TCCTAGCAG-A-----TCT-TCAGAGGGAAGGCATTGAGA-----------GTGGA TGGA---GGGAAGA-------------------------------------CACAGA--- ----------------------TGGCTGAAGGGGGAGGAAGC------------------ -------------------TG-----------------GG--AACCCTGCATGGGGCTAC CGCGCACC-----AGGACTCGTTCCTGGCC----CCCAGTGACTCCT-----GC-GGAAG GGGTGAGTTG---------------------------AACAGGC-AAGGAGCAACCTGCT C-------------------------TCACCATGGGCCTCTGGAATCCCG----GCAGGA GGAGA--CCCCTTGACCA---CCA------------------------------------ ---TGGACACTTGAG--------TTGGCAGGG------------------AGAGCTGCTT AGAGAAGTGGTAGGGGCAGAA---------CTCCAGCCGGTGCAGAGCCCAGAGGG---- ------------TTTGGTGTGGGAGCATCTGTAGTGGAGCATGGC--------------- --------------------CAGGGATGCCCATCCCCCTA----GGCTCAACTTGCTCCC ATAGGAGACTTTA------------GCCCTAGGGG-----------AACTGTCGG----- -----ACCTGAACT-CTGCAGGGCGGTCTTGCCCATGAGACGGGGC-------------- ---CAGTCTGACCTGAGCACCCCTTAGTCTGCTGGCCTCTCCTGGGG-----CCC----- ------------------------------------CAGCCTGGCCATGC---------- -------------------CTGCTTGCAG-TGCAGCC----------------------- -CCCAGGTACCTCCTGGGGGC-------------------CCGCATCATAGCTCCTG--- -----------------------------------------CGCTGGTGGACTGTGCCTG ACTGG--------------------CAGA--------------GTGCTCCAGCAGA---- -------------------GTGGCCACCCTTGCCA----------------CTCCGCAGC CT-------------CCCCTGCCCACGCC----CTCCCT--------------------- -------CCCCTG---------------CAGCCTCCCCTGTGCCACTTT----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------GCCTGCATGCACCCAC-- ---------CCACGGCCACCCCCCACATCGCTTT-----------------------GCC GGCGCATGTGT-------------------------------GCACGGGCGGA------- ----------------------CCTTGCCTTCCCTTCCCTGCCAGCGCGTGTGTGCACAT GCACCCTGCCATGCCACTGCTGCTGGCGTGAGTCCC------------------CTCCCC CCCTCCCCCCCCCCCTG-CCATTGTCGTTGGAG------------------CATT----- -----------------GGCGG-----GCATGGAGCCCGCCAGCCCTGCCCCCACCAGCG CCCTGCCCCTGCGCCAACACTGCCACCAGCGTGAAACTAGGCATGGA------------G AACAGCGGA------CCTGCCC----CC-ACCCTGAGCGGCCACCGCCACCCGCGT---- ---------GAACGTGCACAGAG--------------GGTACACACAGTCCTGTGCCCAC CAG----------------------CACCCTGCCCCCATGCTAACACCACCA------CC AGTG--------AACATGCACACACAGTTGCTGGC---------------------AGGG GC-------CC---CC--CCCCC-----CC-----CCCCCCGA---------------GC CATGCTGCCA--CCGCCGCTGCTGTGAATGCCTGCACGGAGGCCGGCAC----------- -----------C-------------------------CTAGCACCT-------------- -----ACTAGCACCCTGCCGCAGCTAATG-------AGTGTG------------------ ------CACCCCGCCATGCTGCTGCT---------------------------------- ----------------------------------------------GCTGCTGCTGCTGG CATGTGTGAACGAGGATGGAT--CCCG----------------------------CTGCC ACT--------------------G------------------CCCT-ATGAAGTGCTTTG GCTGGCACC----------ACCCATTGGAGTGTT----------GTGACCA--------- ------------GCGGTCTGGGA------------------GCACCTTGGCCC---CTCC ----A-------------GTGCA---------GCAG------------------------ -------------------------------------------GTTCCTAACCTTGAG-- -----------GAGCCAGAGAACAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AGCC-AGGGCCCAATACCAGTCCCCCAGAG TTAGAGCATGCAGTCCAGGAGTCCTGAGCTGAGCCTTGGCCCCCTAAAATCTT-CA---- ------------------------------------------------------------ --------------------GAAATGA------------------------------AGC C-----------AGTTGACTGAACCCACCTTATACC------------------------ ------------------------------------------------------------ -----ACAATCAAACCCCCAAGGT--------CATCAAATAGGAT--------------- ---AAAAGAA-------------------------------------------------- -----------AAAAAAAC----------------------CAT---------------- -----------CCAAAGGACAGC------------------------------------- --AACTTCAA-AGATTGAA--------------G-------------------------- ---GAACATCA------GCCC--------------------------------------- ------------------------AC-------AAAG----------------------- ------------------------AAACTCTT-------GACAACTCAAAAAGCCAGAGT GTCTTCTTTCCTC-----CAA------------ATGACCACACTAGTTCT---------- CCAG---CAAGGGTTCTTA-------ACC-------AGGC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-GATGGCTG AAAT------GACAGAAA------TAGAA------------TTCAGAAT---ATGGAT-A GGAATGA---AGATCATCAAGAT----TCAGGAGAATG---------------------- ------------------------------TTGAAACCCAATCT---AAGGAAGC----- ----------------------------------------T------------------- -------AAGAATCACAATAAAATG---ATACAGGAGCT--------------------- ----------------------GACAG-------------ACAA------AATAGCCAGT --------------------------------------ATAGAAAAGAAT---------- -----GTAACTAACC--------------------------------------------- ------------------------TGAT-AGAGC---TGAAA---------AACAC---- -ACTACAAGAA----TTTCATAATGCAATCA-------CAAG------------------ --------------------------------------------TATTAACAGCAGAAT- -----AGACC--AAGC------------------TGAGG---------AAAG-AAT-CTC AGAGCTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACTGGCTTTCTGAAA-T--AAGACAG------TCAG---------ACAA--- ------------------GAATAAAGAAAAA---AGA---ATAAAAAGGAA--------- CAA-ACAAAACCTCCAA--GAAATATGGG-ATTATGTA-----------AAGAG--ACCA AATCTATGAC-TCATTGG--CATCCCTGAAA--------------GAGATGGGGAGAATG GAAGCAACTTGG---------AAAACATATTTCA--G--------GATATCATCCA-T-G AGAACTTCCCCAACCT--------------------AGCTAGAGAGGCCA--ACATTCAA ATTC-----AGGAAATGCAGAGAAC---CCCCAC-AAGAT--------ACT--------- ---T-CACAAGAA-----GATCATCCCCAA----------------------------GA CACATAATCATCAGATT------CTC-CAAGG---------TTGAAATGA---------- ------------AAG--AAAAAATGT---------------------------------- --------TAAAGGCAGCTAGAGA---GAAAGGAC--------------AGGTCAC---C TAC----------AAAG--------------GGAAGCCCAT--CAGACTAA-C--AGTAG ACC--------TCTCAGCAGAA--ACCCTA-CAAG--CCAG-AAGAGATTG--------- ----GGG-GCCTATA-T-------TCAACA--T-TCT-TAAAGAAAAG------------ -AAA-TT--CCA--ACCAAGAA--------TTTCAT----------ATCCA--------- --GCCAAACTAAGC-----TTCA-TAAGTAA-------AGG-AGAAATAAGATCCTTTTC AGACAAGC-AAATGCTGAGGGA-ATTTGTTACCACCAGAC---CTGCCTTAC-AAGAGCT CCT--------------GAAAGA----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------AGACCATTACCAGC CACTAC------AAAAACACACT------T---------------TAAG-----TACACA ----GA------CCAGTGACACT----ATAA-------AGCAACCAC-----ACAAACAA GTCTGCATAATAACCAGCTAACAAC-------------------------------A--- ------------------------------------------------TGTGACA----- --------------------GGATCAA--ATCC-ACACATATCAATAC------------ -------------TAAC-CTTGAATG-TAAATGGGCT--AAATGC---CCCAATTAAAAG GCACAGAG--TGGCAAGC-TGGAT------------AAAAAAGCAAGACCCAATGG---- ---TAT-GCTGTCTTCAAGAG-ACCCATCT-CACAT--GCAATGACACCCATAGGCTCAA AA--TAAAGGGA--TGGAGAA-AAATCTACCAAGCAAATGG------AAAAC-------- -------------AGAAA-AAAGCAG--GGGTTGCAATCCTAATTTC-AGACAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAAAGAC-AAAG-AAGGGCATTACAT-- ----AATGGTAAA---GGGTTCAATTCAAC--AAGAAG--------AC-CTAACTATCCT AA-----------------ATATATATGCACCCAACACAGGAGCACCCAG--ATTCATAA AGCAAGTTCTTAGAGACCTACAAAGAGACTTAGACTCCCACAC---------AATAATAG TGGGAGACTTCAACACTCCAC-----TGACAGTATTAGACAGA----------------- ----TCATTGAGGC------AGAA-----AATTAACAAAGATATTCAGGACCTG------ --AACTCAACATTGGACCAAATGGAT-CTGATAG--ACCTCTACAGAA--CTCTCCACCC CAAAACAA---CAGAATATACATTCTTCTCA-------TTGCCACAT---GGCACATACT C------TAAAATCGACCACACAATTGGACATAAAACAAT-------------------- -CCTCAGCAAATGCAAAAGAA--CTGAAAT----------------CATACCAA------ -ACACACTCTCA---GACCACAGCACAA-TAAAAATAGAAATCAAGACTA--------AG A-------------AA-ATCACTC---AAAACCATACAA----TTACATGGAAATTAAAC AACCTG-CTCCTGAA---TG-ACTTTTG--GGTAA---ATAATGAAAT--TAA-GGCAGA AATCAAGAAGTTCTTT---GAAAC------------------------TAATGAGAACAA -AGATACAAC--ATACCAGAATCTC-TGG-GACACAGCTAAGGCAGTGTTAAGAGGGAAA --TTTATAGCACTAAATGCCCACATCAAAAAGT---TAGA--AAGATCT---CAAATTAA ------CAACCTAACATCACAACTAAA---AGAACTAGAGAA---GC---AAGAGCAAAC CAACCCCA-AAGCTAGCA------------GAAGACAAGAAATAAC-CAAAATCAGAGCT GAACTG---AAGGAGATTGAGACACAAAAAA-CCA---TTCAAAAATTA-AAAAAACCAA -GGAGT-------TGTTTTTTTGAAAAAATTAA--------------------------- -----------------------------------------------------------T AA-----GA------TAGATAGGCCA---CTAGCTA------GACT-------------- AATAAAGAAGAAAAG---A---GAGA-AGATCCAAATAAA-------------------- -----CACAA---T---------TAGAAATGACAAA------GGGGA---TGTTACCACT G--------ACCC-CACAGAAATA-CAAATAACC--ATCAG---------AGACT----- -------------------ACTATGAACAC-CTCTATGCACACAA--AC---TAGAAAAC CTAG---AAGAAAT--GGATAAATTCCT--G---GACACA---------TAC-----ACC CTCCCA------AGACTGAACCAGGAAGAAATTGAATCCCTGAAC--------------- --------AGACCA------A------TAATGAGCTCTGAAAT----TGAAT--CAGTAA -TAAATAGCCTACCAACCAAAAAAAG--CC-CAGGACC--AGATGGATTCACAGCCAAA- TTCTA------------CCAGATGTAC----AAAGAAGAGCTGGTA-CCATTC-----C- ----TACTGAAACTATTCCAA-------AAAATTG-AGGAGGAGGG-----------ACT CCTCCCCAACTCATTCTATGAG---------GCCAGCAT---CATCCTGATACC--AAAA C-----------------------CTGGC--AGAGACA-CAAC----AA---------AA AAAGAAAACT---------------------TCA------GGCCAATAT--CCT----TG ATGAACATTGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACCA------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGCTAATCCA--CCA ----TGAT------------CAAGTAGGC-TTTATCCCTGGGA-TGCAAG---------- -------------GTTGGTTC-AAC-----ATATGC----AAATCAATAAATGTG--ATT CATCAC---------A------TAAACAG----AACTAAAGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAGG---CTTTCAATAA---AA TTCAACATCCCTT-------------------CATGT---------T-AAAAAC-TCTCA --ATAAACTAGGTATTGAAGGAACAT-----ACCTCAAAATAAT---------------- -----------AAGAGCCAT-CTAT-GACAAACCCACAGC-----------CAACAT--C ATACTGAATGGGCAAAA-G-----CTGGAAGC-ATTC---CCCTTGAAAA----CTGGCA CAAGACAAGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTATT---GGAAG TCCTGGCCAG--------AGCAATCAG------GCAAGAG---AAAGA--AATAAAGGGC ATCCAAATAGGAAG-------AGAGGAAGTCAAA--CTATCCCTG-----TTTGCAGATG AC--ATGATTCTA-------TATCTAGAAAACCCC---------------ATAGT---CT CAGCCC---------AAA--AGCTCCTTCAGCT---------GATAAA--CAACTTCAGC AAAG--TT-------------------------TCAGGATACAA--------------AA TCAATGT------------ACAAAAAT----CACTAGCATTCC--TA-TACACCAA--CA ACAGCCAAGCCGA------------------GAGCCAAA-TCAGG----AATGCAATCCC ATTCACAATTGC-CACAAA---AAGAATAAAATACCTAGGAATACAGCT--------AAC -CAGGGAGGTGAAAGATCTCT---ACAATGAG--AATTACAAAACACTGCTC-AAAGAAA TCAGAGA-----------TG------------------ACAC--AAAC--AAATGGAAAA ACAT------T---CCATGCTCATG------GATAGGAAGAATC-----AATA-TCATT- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----AGCAATTTACAGA---TTCAATGCTATTCCTATCAAACT---------ACCAATG- AC------------ATTCTT---------------------------------------- --CACAGAACTAG---AAA------AAACTATTTTAAAA-TTCATATGGAA-------CC AAAAAAGAGCCC---AA--ATAGCCAAGGCAATCCTAAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACA---TTACCTGACTTCAAACT-----ATACTACAG---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CAAA AACAGACA------CATAGAC--CAATGGAACAGAATAGAGAGCCC------AG--AAAT AAG---GCCACACACCTACA----ACCATC--TGATCTTT---GACAAA--GCTGA--CA AAAACAAGC--AATGG-----GGAAAGG----ACTCC--------CTATT--CAATAAAT GGTGCTG----------G-GATAAC--TGG-C-TAGCCA---------------TATGC- AGA---------AGA--TTGAAACTGGACCCCT----TCCT---------------TACA CC--ATATACAAAAA-TCAACT-CAAGATGGATTAAAGACTTAAATGTA--AAACCCAAA ACT-AT------------------------AAAAACCCTGGAA----------------- ------GACA--ACCTA------G---------GCA---------ATACCATTCTGGAC- --ATA-----GG-AACTGGCAAAGATTTCATGACGAA-GACGCCA-AAA----GCAATTG CAACAAAAGCAAA----A------AT---TGAC--AAA-TGGGATCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTATCAAC-AGAG-TAAACAG-ACAAC CTAC--AGAA--T-GGGAG--AAAATATTT---GCAAACTATGCAT--------CTGACA AAGGTCTAA-------TATCCAGCATCTATA--AGGAA--CTTAA-----ACAAA----- ----------------------TTTAC------------AA---------------A--- AACAACCCCA-TTAAAA----------AGTGGGCAAA-----------GGA--CATGAAC ---AGACACTTTTCAAAAGAAGACATACATG--------------TGGCCAAC-AAGCAT ATGAAAAAAAG----CTCAATATCACTGA-TCATTAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACACCAGTCAGAATGGCTA-- ----TTATTAAAA---AGTCAAAAA-----------ATAACAG--ATG--CTGGC-G--- ---------------AGGTTGTGGAGAA-------------------------------- -----AAAGG----------ACACTGTTGG--TGGGAG---------------------- -------------TGTA-------------AATTA-GTTCAACC--------ATTGTGG- -------AAAGCA-GTGTGGCA--ATTC-CTCAAAGAGCTAAAA--ACAGAACTACCA-- -TTTGA--CCCAGCAATCCCATTACTGGG-TATATA-CCCAAAGG-AAT--ATAA----- -------------------ATTATTCT-ACCAT--AAAGACACATG----------C--- ---------ACGTG--TATGTTCATTGCAGCACTATT---CACAATA-GCAAAGACAT-G GA--ATCA--ACCTAAA-TGCCCATCA---ATGGTAG-----ACTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AAGAATGAGATCATGTCCTTT----------- ------------------------------------------------------------ -GCAGGAACATGGATGGAG-C---T----------------GGAGGCCATTATCCTTAGC AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------ACGCA--GGAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAA---- -----------------------------CCAAATAC-CACATG--------TTC----- ------TCACT---TAT------------------------AAGTGGGAGC---CTAAAT G-------A--------------TGAGAA---------------C--------------- ------------------------------------ACATG-------------GACA-- -------CA------------------------------------------AAGAGG--- -GGAACAACAGA---CACTG-----GGGCCTACC---------TGAGGG----------- TGG-AGGGTGGG------------------------------------------------ --AGG-------AGGGAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGG----------AGCAGAAAAAAATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ACTATTG---------------------------------------------- --------GGTA----CTAGGCTT----------------------AGTACCTGGGT--G ACGAAA--------------------------------------TAATCTGT-------A CAA-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCCCCATG-- -------------------ACACG-AGTTTA--------C-------------CTATA-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA-----AACC---------------------------------------------- -----------TGCACA-------------------------------TGTACC------ ------------------------------------------------------------ -------------------------------------------------CCT-------- --------------GAACC------------TAAAATA----AAAGTTTA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA14 ---------------------------GAGGTGGCCAAGATG--GCCGACT-AGAAGCAG CTAGTGTGCGT---GGCTCTCA--------CAGAGAGGAATG------------------ ---------------------GAAG----------GGGCGAGTAAATAC--------AGC AC--CTTCAACTG-A-----AACATCCAGGTACTCGCATTGGGA-----------CTAAT CAAG---GAAACAAC--TTG--------------A--------------CCCACGGAGAA T---------------------GGAGAAAAGCAAGGCAGGACGATG-------------- ------------GCCCACCTG-----------------GG--AGCA--ACATGGAGCCA- -------------GGGG---AACC----TC----CCCTG-----CCC-----AG-GGAAG CGGTGAGTGAATGTGT------G--------------ACCCCG-----GGAACCCACGCT T-------------------------CTCCCATGGATCTTTGCAACCCTC----AGGTCA GGAGAT-CCCCTTGTGAA---CCC------------------------------------ ---ACTCCACCAGGGCCTTCAGTCTGACAGAC------------------AGAGCTACGT GGAGTCTTGGCAGAGCAGCCA---------CTCAGGCACACGTGGAGACCTGGGAG---- ------------CCTTAGATACTTGGGCTTTCCGGGCTTCCCAGCAAAAGTAGCTGCAAC TCTGGCAAAGTGGGAGGTTAGACCCCTGTACATACCCCTA----GGA------------- --AAGAGGCTGAA------------TCCAGGGGGCTGAGCAGCAACAGTCTGCAG----- -----GCCCCACTT-CCATGGCAC-------CTCACAGGATAAGAC-------------- ---CCACTGGCTTGGAATTCCAGCCAGCCACT-------------GG-----TAG----- ------------------------------------CAGCATTGCAC------------- -------------------CTCCC------TGAGACG--GAGCTCCCA------------ ----GGGGG------AGGGGTG------------------GGCCGCCATCTTTGCTG--- -----------------------------------------TTT-GGGCAACTTAGCCAT TCCAGCCTTCGGGCTTTGGAGAGTCCAAG--------------CTGACCAGGGGTG---- -------------------GAAGGGATCCCC-CAG----------------CACAGCACA GC-------------TGCTCTACAAAAAT----GTGGCC--------------------- -------AGACTG---------------CTTCTTTAAGCAGGTCCCCGA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TCCTG-----TTCCTCCTCACTGG-----------------------GTG GG-ACCTCCCA-------------------------------ACCGGGG----------- --------------------------------------CCTCCAGCC------------- -ACCCCTACTGGTGTTCTCTGGCTGACAGAGATTTG------------------AAACCT CCCTG--------------------GGATGGAG------------------CTCC----- -------CAGAGGGAGGGGTGG-----GCC-----ACCAT-------------------- CTTTGCTGTTTGGGTGAC------------------------------------------ -TTAGCTAT------TCCAGCC--TTTGGGCTTTAGAGTGTCTGAGGCAACCGGGG---- ---------GCT-----GAAGTG--------------GA-----------------CCCC CAG----------------------CACAGCACAGCTGCTCTATGAAAAC--------GT GGCC--------AGACTGC--------TTTTTTAA---------------------GTGG GT-------CC---CCGA-TCCC-----AT-----TCCTCCTC---------------AC TGGGTGGGAC--CTCCCA---------------ACTGGG------GTCT----------- -----------C-------------------------CAGCCACCTCCT----------- -----ACAGGTGCGTTTGGGCCAGCAACA-------GGTCTG------------------ ------TACCTCCCTGGGATGGAGCT---------------------------------- ----------------------------------------------CCCA---------- -----------GAGGGAGGGG--CAGG----------------------------CTGCC ATCTTT-----------------G------------------CTGTTTTGCAGC--CTTC ACTGGTGAT----------ACCTCCAGGTACTGGAAAATCTGAGGTGACTA--------- ------------G-GGACTGGAG------------------------CAGGCC---CCCA GCATA-------------CCGCA---------GCAG------------------------ -------------------------------------------C--CCTACGGAAAAG-- -----------TGGCCAGACTGTTACATGGGTGCCTGTTCCCATATCTCCTCACTGGGCA GGTCCTCCAGGCCTGGGCCTCCAGCCACCCCCTGCCAGAGCTATTGAGCCAGTAGCAACT CAGCAACTCCCTGGACAGAGCCTCCAGGGGCAACTGAAAGCCTCTCTGCCACTGCCTCTG CAGTGGAACTGCCCTTGCTACCCTCGGACTAACGAAGGAGCAAAGACCCTAAGTGCCTTA TCCACACCTCCAACAAGCTGCAGTTGACCCAAGGAGAGGAGGCCAGTCCATCTCCCATGG GTCCCACACACCCCCCACTGCTCGTCACCAGACAGGGAACCCCTGGCTTGGGCCCACAGC ACAGACCCTCCATCCTGGGCTGATTGCACTGAGTGATTGCTGACCTGCATCTCTCTGGGG TGGAGCCCCCAGGAGACAAGCAAAAGACCCTTGGCCACAACCACTACTAAGGTCCCTTCC TCTGCTGCCTCCAAGTTGGGGAAGGAA------------------------------CAT A-----------AAC--ACTGAGATTGCCCCAGAGCTGCAGTGGGCAGCCCAGGAGTGCC AAGCCATGATCTACAGCCAGCACTCAAGGGGGAGAGGAACCCACACTTTCAGAGCATTGA GAGGGAACATGGCTGCAACTGTGA--------GGAAACATAGGGGAGCCACACAACTGAG CAAGAGTCTACCAACTGACCAATAAGCCTAAGTGCCACCTACTGGATCACACCCCAAAGC TTCAACACCAAAAATACCT----------------------CACTAACATACCCCCCTCT GAAACCAGAGACAAGAAGTCAGCTTCAAATAAAGACCCTGCACAAAGCCTCGGCCCAGTG AAAACATCCA-GAAAAGAA--------------GTCTATTGACTGTACTCAATCTACACT ---GCAGTTAAAGGAACACCC--------------------------------------- ------------------------ACATGCATGAGAATGAGAAA---------------- ------GAACCAAT-------GCAAGAACTCT-------GGTAACTCAAATGGCCAGAGT GTCATATGTCCTC-----CAA------------ATGACTACACCAGTTCT---------- CCAA---CAAGAGTTCTTA-------ACC-------AGGC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-ACTGGCTG GAAT------GACAGAAA------TAGAA------------TTCAGAAT---ATGGAT-A GGAACAA---AGATCATTAAGAT----TCAGGAGGATG---------------------- ------------------------------GCAAAACCCAATCC---AAGGAAAA----- ----------------------------------------T------------------- -------AAGAATCACAATAAAGTG---ATACAGGAGCT--------------------- ----------------------GAAGG-------------ACAA------AATAGCCAGT --------------------------------------ATAAAAAAGAAC---------- -----CTAATGGGTC--------------------------------------------- ------------------------TGAC-AGAGC---TGAAT---------AACAC---- -AATACAAGAA----TTTCACAATGCAATCA-------CAAG------------------ --------------------------------------------TATTAACAGCAGAAT- -----AAACC--AAGC------------------TGAGG---------AAAG-AAT-CTC AGAACTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACTGGTTCTCTGAAA-T--AAGACAG------TCAG---------ACAA--- ------------------AAATAAAGAAAAA---AGA---ATAAAAAGGAA--------- TGA-ACAAAACCTCCAA--GAAGTATGGG-ATTATGTA-----------AAGAG--GCCA AATCTACAAA-TCATTGG--CATCCCTGAAA--------------GGGAGGGGGAGAAAG CAAACAACTTGG---------AAAACATATTTCA--G--------GATATCATCCA-T-G AAAACTTCCCCAACCT--------------------TGCTAGAGAGGCCA--ACAGTCAA ATTC-----AGGAAATACAGAGAAC---TCCTGC-AAGAT--------TCT--------- ---A-CACAAGAA-----GATCATCCCCAA----------------------------GA CACATAATCATCAGATT------TTC-CAAGG---------TCAAAATGA---------- ------------AAG--AAAGAATGT---------------------------------- --------TAAAGGCAGCTAGAGA---GAAAGGGC--------------AGGTCAC---C TAC----------AAAG--------------GGAACCCCAT--CAGGCTAA-C--AGTGG ACC--------TCTCAGCTGAA--ACCCTA-CAAG--CCAG-AAGAGATTG--------- ----GGG-GCCTATA-T-------TCAACA--T-TCT-TAAAGAAAAA------------ -AAT-CT--TCA--ACCAAGAA--------TTTCAT----------ATCCA--------- --GCCAAACTAAGC-----TTCC-TAAGTGA-------AGG-AGAAATAAGATCCTTTTC AGATAAGC-AAATGTTGAGGGA-ATTTATTACCACCAGAC---CTGCCTTAC-AAGAGAT CTT--------------GAAAGG----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATAG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------AGACCACTACCAGC TAATAC------AAAAACACTTA------A---------------AC--------ACACA ----GA------CCAGTGTCACT----ATAA-------AGCAACCAC-----ACAAACAA GCCAACATAATAACCAGCTAACAACACAA-------------------------TGA--- ------------------------------------------------CATGACA----- --------------------GGATCAA--ATCC-ACACATATCAATAC------------ -------------TAAC-CTTGAATG-TAAATGGGCT--AAATGC---CCCACTTAAAAG GCACAGAG--TGGCAAGC-TGGAT------------AAAAAAGCAAGACCCAATGG---- ---TAT-GCTGTCTTCAAGAG-ACCCATCT-CACAC--GTAATGACACTCATAGGCTCAA AA--TAAAGGGA--TGGAGGA-AAATCTACCAAGCAAATGG------AAAAC-------- -------------AGAAA-AAAGCAG--GGGTTGCAATCCTAATTTC-AGACAAAACAGA TTTCAAA-CC----------AACAAAGATCAAAAAAGAC-AAAG-AAGGGCATTACAT-- ----AATGGTAAA---GGGTTCAATTCAAC--AAGAAG--------AC-CTAACTATCCT AA-----------------ATATATATGCACCCAACACAGGAGCACCCAG--ATTCATAA AGCAAGTTCTTAGAGACCTACAAAGAGACATAGACTCCCACAC---------AATAATAG TGGGAGACTTCAACACTCCAC-----TGACAGTATTAGACAGA----------------- ----TCATCGAGGC------AGAA-----AATTAACAAAGATATTCAGGACCTG------ --AACTCAACATTGGACCAAATGGAT-CTGATAG--ACCTTTACAGAA--CTCTCCACCC CAAAACAA---CAGAATATACATTCTTCTCA-------TCGCCACAT---GGCACATACT C------TAAAATCGACCACATAATTGGACATAAAACAAT-------------------- -CCTCAACAAATGTAAAAGAA--CCGAAAT----------------CATACCAA------ -ACACACTCTCA---GACCACAGTACAA-TAAAAATAGAAGTCAAGACTA--------TG A-------------AA-ATTGCTC---AAAACCATGCAA----TTACATGGAAATTAAAC AACATG-CTCCTGAA---TG-ACTTTTG--GGTAA---ATAATGAAAT--TAA-GGCAGA AATCAAGAAGTTCTTT---GAAAA------------------------TAATGAGAACAA -AGATACAAC--ATACCAGAATCTC-TGG-GACACAGCTAAGGCAGTGTTAAGAGGGAAA --TTCATAGCACTAAATGCCCACATCAAAAAGT---TAGA--AAGATCT---CAAATTAA ------CAACCTAACTTCACAACTGAA---AGAATTAGAGAA---GC---AAGAACAAAT CAACCCCA-AAGCTAGCA------------GAAGACAAGAAATAAC-AAAAATCAGAGCT GAACTG---AAGGAAATTGAGACACAAAAAA-CCA---TTCAAAAGATC-AATGAATCCA -GGAGT-------TGGTTTTTTGAAAAAATTAA--------------------------- -----------------------------------------------------------T AA-----AA------TAGATAGGCCA---CTAGCTA------GACT-------------- AATAAAGAAGAAAAG---A---GAGA-AGATCCAAATAAA-------------------- -----CACAA---T---------TAGAAATGATAAA------GGGAA---TGTTACTACT G--------ACCC-CACAGAAATA-AAAACAACC--ATCAG---------AAACT----- -------------------ACTATGAACAC-CTCTATGCACACAA--AC---TAGAAAAC CTAG---AAGAGAT--GGATAAATTCCT--G---GACACA---------TAC-----ACC CTCCCA------AGACTGAGCCAGGAAGAAATTGATTCCCTGAAC--------------- --------AGACCA------A------TAATGAGCTCCAAAAT----TGAAT--CAGTAA -TAAATAGCCTACCAACCAAAAAAAG--CC-CAGGACC--TGATGGATTCACAGCCAAA- TTCTA------------CCAGATGTAC----AAAGAAGAGCTGGTA-CCATTC-----C- ----TACAGAAACTATTCCAA-------AAAATTG-AGGAGGAGGG-----------ACT CCTCCCCAACTCATTCTATGAG---------GCCAGCAT---CATCTTGATACC--AAAA C-----------------------CTGGC--AGAGACA-CAAC----AA---------AA AAAGAAAACT---------------------TCA------GGCCAATAT--CCT----TG ATGAACATTGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTTGC-AAACCA------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGCTAATCCA--CCA ----TGAT------------CAAGTAGGC-TTCATCCCTGGGA-TGCAAG---------- -------------GTTGGTTC-AAC-----ATATGC----AAATCAATAAATGTG--ATT CATCAC---------A------TAAACAG----AACTAAAGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAGG---CTTTTGATAA---AA TTCAACACCCCTT-------------------CATGT---------T-AAAAAC-TCTCA --ATAAACTAGGTATTGAAGGAACAT-----ACCTCAAAATAAT---------------- -----------AAGAGCCAT-CTAT-GACAAACCCACAGC-----------CAACAT--T ATACTGAATGGGCAAAA-G-----CTGGAAGC-ATTC---CCCTTGAAAA----CCGGCA CAAGACAAGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTTCTATTCAA-CATA--GTATT---GGAAG TCCTAGCCAG--------AGCAATCAG------GCAAGAG---AAAGA--AATAAAGGGC ATCCAAATAGGAAG-------AGAGGAAGTCAAA--CTATCTCTG-----TTTGCAGATG AC--ATGATTCTA-------TATCTAGAAAACCCC---------------ATAGT---CT CAGCCC---------AAA--AGCTCCTTCAGCT---------GATAAA--CAACTTCAGC AAAG--TT-------------------------GCAGGATACAA--------------AA TCAATGT------------ACAAAAAT----CACTAGCATTCC--TA-TACACCAA--CA ACAGCCAAACTGA------------------GAGCCAAA-TCAGA----AAGGCAATCCC ATTCACAATTGC-CACAAA---AAGAATAAAATACCTAGGAATACAGCT--------AAC -CAGGGAGGTGAAAGATCTCT---ACAATGAG--AATTACAAAACACTGCTC-AAAGAAA TCAGAGA-----------AG------------------ACAC--AAAC--AAATGGAAAA ACAT------C---CCATGCTCATG------GATAGGAAGAATC-----AATA-TCATT- ------------------------AAAATGGCTA-TA-CTGCCC-AA------------- ----AGCAATTTACAGA---TTCAATGCTATTCCTATCAAACT---------ACCAATG- AC------------ATTCTT---------------------------------------- --CACAGAACTAG---AAA------AAACTATTTTAAAA-TTTATATGGAA-------CC AAAAAAGAGCCC---AA--ATAGCCAAGGCAATCCTAAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACG---TTACCTGACTTCAAACT-----ATACTACAA---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CAAA AACAGGCA------CATAGAC--CAATGGAACAGAATAGAGAGCCC------AG--AAAT AAG---GCCACACATCTACG----ACCATC--TGATCTTT---GACAAA--GCTGA--CA AAAACAAGC--AATGG-----GGAAAAG----ACTCC--------CTATT--CAATAAAT GGTGCTG----------G-GATAAC--TGG-C-TAGCCA---------------TATGC- AGA---------AGA--TTGAAGCTGGACCCCT----TCCT---------------TACA CC--ATATACAAAAA-TCAACT-CAAGATGGATTAAAGACTTAAATGTA--AAACCCAAA ACT-AT------------------------AAAAACCCTGGAA----------------- ------GACA--ACCTA------G---------GCA---------ATACCATCCTGGAC- --ATA-----GG-AACGGGCAAAGATTTCATGACAAA-GACACCA-AAA----GCAATCA CAACAAAAGCAAA----A------AT---TGAC--AAG-TGGGATCTA--AT-------- -------------------------------------------------------T-AAA CTTAAGAGCTT-CTGCA---CAGC-AAAAGAAACTATCAAC-AGAG-TAAACAG-ACAAC CTAC--AGAA--T-GGGAG--AAAATATTT---GCAAACTATGCAT--------CTGACA AAGGTCTAA-------TATCCAGCATCTATA--AGGAA--CTTAA-----ACAAA----- ----------------------TTTACAAGAG------AAAAAC------------A--- AACAACCCCA-TTAAAA----------AGTGGGCAAA-----------GGA--CATGAAC ---AGACACTTCTCAAAAGAAGACATACATG--------------TGGCCAAC-AAGCAT ATGAAAAAAAG----CTCAATATCACTGA-TCATTAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACACCAGTCAGAATGGCTA-- ----TTATTAAAA---AGTCAAAAA-----------ATAACAG--ATG--CTGGC-A--- ---------------AGGTTGCAGAGAA-------------------------------- -----AAGGGAACACTTAT-ACACTGTTGG--TGGGAG---------------------- -------------TGTA-------------AATTA-GTTCAACC--------ATTGTGG- -------AAAGCA-GTATGGCG--ATTC-CTCAAAGAGCTAAAA--GCAGAACTACCA-- -TTTGA--CCCAGCAATCCCATTACTGGG-TATATA-CCCAGAGG-AAT--ATAA----- -------------------ATCATTCT-ACCAT--AAAGACACATG----------C--- ---------ACGCA--AATGTTCATTGCAGCACTATT---CACAATA-GCAAAGACAT-G GA--ATCA--ACCTAAA-TGCCCATCA---ATGACAG-----ATTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AAGAATGAGATCATGTCTTTT----------- ------------------------------------------------------------ -GCGGGAACATGGATGGAG-C---T----------------GGAGGCTATTATCCTTAGC AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------ATGCA--GGAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAA---- -----------------------------CCAAATAC-CACATG--------TTC----- ------TCACT---TAT------------------------AAGTGGGAGC---CTAAAT G-------A--------------TGAGAA---------------C--------------- ------------------------------------TTATG-------------AACA-- -------CA------------------------------------------AAGAAG--- -GAAACAACAGA---CACTG-----GGGTCTACT---------TGAGGG----------- TGG-AGGGTGGG------------------------------------------------ --AGG-------AGGGAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGG----------AGCAG-AAAAGATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ACTATTG---------------------------------------------- --------GGTA----CTGGGCTT----------------------AATACCTGGGT--G ATGAAA--------------------------------------TAATCTGT-------A CAA-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCCCCGTG-- -------------------ACACG-AGTTTA--------C-------------CTATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA-----AA------------------------------------------------ --------CC-TTCACA-------------------------------TGTACC------ ------------------------------------------------------------ -------------------------------------------------CCC-------- --------------AAACC------------TAAAATA----AAAGTTAAA------AA- -------A---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA12 -----------------------------GGGGGCCAAGATG--GCTGACT-AGAAGCAG CTATGGTGTGT---GGCTCTCA--------CGGAGAGGAATG------------------ ---------------------AAAG----------GGGTGAGTAAATAC--------AGC AC--CTTCAACTG-A-----AACATCCAGGTACTCGCATTGGGA-----------CTGAT CAGG---GAAACAGC--TTG--------------A--------------CCCACGGAGAA T---------------------GGAGAAAAGCAGGGCAGGGCAATG-------------- ------------GCCCACCTG-----------------GG--AGTA--ACATGGAGCCA- -------------AGGG---AACCCCCATC----CCCAG-----CCC-----AG-GGAAG CGGTGAGTGAATGTGT------G--------------ACCCTG-----GGAAACCACGCT T-------------------------CTCCCATGGATCTTTGCAACCCTT----GGATCA GGAGAT-CCCCTTGTGAA---CCC------------------------------------ ---ACTCCACCAGGGCCTTCGGTCTGACACAC------------------AGAGCTGTGT GGAGTCTCGGCAGAGCAGCTG---------CTCAGGCATGCACAGAGACCCAGGAG---- ------------CTTTACATACTCGGGC--TCTGGGATCCCCGGCAAAGGTGACTGCAAC TCAGGCAAGGCGGGAGGTTGGACCTCCGTACATACCCCTA----GGA------------- --AGGGGGCTGAA------------TCCAGGGGGCTGAGCAGTGTCAGTCTGTGG----- -----GCCCCACTT-CCATGGCAC-------CTCACAGGATAAGAC-------------- ---CCACTGGCTTGGAATTCCAGCCAGCCACC-------------GG-----CAA----- ------------------------------------CAGTGTTGTAC------------- -------------------CTACCTGGGAATGGGACG--GAGCTCCTG------------ ----GGGGG------AGGGGCG------------------GGCTGCCATCTTTGCTG--- -----------------------------------------TTT-GGATAACTCAGCCAT TCCAGCCTGTGGGCTTTGGAGAGTCCAAA--------------CCAACTGGGGATG---- -------------------GAAGGGATCCCC-CAG----------------CACAGCACA GC-------------TGCTCTACCAAAAT----GTGGCC--------------------- -------AGACTG---------------CTTCTTTAAGCAGGACCCTAAATCCATTTCTC CTCACTGGGCGGGACCTCCCAACTGGGGCCTCCAGCCACCCCGCCGATATCCTCCGGCTG GCAGAGTTTTGATTTCTCCCTGGGATGGAGTGCCTGGGGGGAGGGGCGGGCCACCATCTT TGCTGTTTGGACAACTTAGCCATTCCAGCCTGTGGGCTTTGGAGAGTCCAAACCGACTGG GGCAGAAGTGGTCCCCCAGCACAGCACAGCTGCTCTACCAAAGCATGGCCAGACTGCTTC TTTAAGTGGTCCCTGAACCATTCCTCCTCACTGG-----------------------GTG GG-ACTTCCCA-------------------------------ACCGGGG----------- --------------------------------------CCTCCAGCC------------- -ACTCCCGCCAATGTTCTCTGGCTGACAGAGATTTG------------------AAATCT CCCTG--------------------GGACAGAG------------------CTCC----- -------TAGAGGGAGGGGTGG-----GCT-----GCCAT-------------------- CTTTGCTGTTTGGGCAAC------------------------------------------ -TTAGCTGT------TCCAGCC--TTCAGGCTTTGGAGAGCCCAAGCTGACCAGGG---- ---------GCA-----GAAGCG--------------GT-----------------ACCC CAG----------------------CACAGCACAGCTGCTCTACGAAAAT--------GT GGCC--------AGACTGC--------TTCTTTAA---------------------GTGG GT-------CC---CTGA-TCCC-----AT-----TCCTCCTG---------------AC TGGGTGGGAC--CTCCCA---------------ACTGGG------GTCT----------- -----------C-------------------------CAGCCACCTCCT----------- -----ACAGGTGCGTTTGGGCCGGCAACA-------GGTCTG------------------ ------TACCCCCCTGGGACGGAGCT---------------------------------- ----------------------------------------------CCCA---------- -----------GAGGAAGGGG--CAGG----------------------------CTGCC ATCTTT-----------------G------------------CTGTTTCACAGC--CTTC ACTGGTGAT----------ACCTCCAGGTACTGGAAAATCTAAGGTGACTA--------- ------------G-GGTCTGGAG------------------------TGGACC---CCCA GCAAA-------------CTGCA---------GCAG------------------------ -------------------------------------------C--CCTATAGAAAAG-- -----------TGGCCAGACTGTTAAATGGGTGCCCATTCCCATATCTCCTCACTGGGCA GGTCCTCCAGGCCTGGGCCTCCAGCCACCCCCCGCCAGAGCTATCGAGCCAGTAGCAGCT CTGCAACTCCCTGGACAGAGCCCCCAGGGGCAACTGAAAGCCTCTCTGCCACTGCCTCTG CAGTGGAACTGCCCTTGCTACCCTCAGATTAATAGAGGAGCAAAGACCCTAAGTGCCTTA TCCACACCTCCAACAAGCTGCAGTTGACCCAAGGAGAGGAGGCCAGTCTGTCTCCCATGG GTCCCACCCACCCCCCACTGCTCATCACCAGACAGGGAACCCCTGGCTTGGGCCCACAGC ACAGACCCTCCATCCTGGGCTGATTGCACTGAGCGATTGCTGACCTGCATCTCTCTGGGG TGGAGCCCCCCGGAGAAAGGCAAAAGCCACTTGGCCACAACCACTACTAAGGTCCCTTCC TCTTCTGCCTCCAATATGGTGAAGAAA------------------------------AAT A-----------AACAAACAAAGATCACCCCAGAGCTGCAGTGGGCAGCCCAGGAGTGCC AAGCCATGATCTACAGCCAGCACTCAAGGGGGAGAGGAACCCACACTTTCAGAGCATTGA AAGTGAACACAGCTGCAACTACAA--------GGAAACACACGGGAGCCACACAACCGAG CAAGAGTCTACCAACTGACCAACA------------------------------------ --------CACAAAAACCC----------------------CAT---------------- -----------CCAAAGGTCAGC------------------------------------- --AACCTCAA-AGATTGAA--------------G-------------------------- ---GTAGATAA------GCCC--------------------------------------- ------------------------AC-------AAAGTGAGAAA---------------- ------GAACCAAT-------GTAAGAACTCC-------GGTAACTCAAATGGCCAGAGT GTCATATGTCCTC-----CAA------------ATGACCGCACCAGTTCT---------- CCAA---CAAGAGTTCTTA-------ACC-------AGGC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-ACTGGCTG GAAT------GACAGAAA------TAGAA------------TTCAGAAT---ATGGAT-A GAAACAA---AGATCATTGAGAT----TCAGGAGGACG---------------------- ------------------------------GCAAAACCCAATCC---AAGGAAAA----- ----------------------------------------T------------------- -------AAGAATCACAATAAAGTG---ATACAGGAGCT--------------------- ----------------------GAAGG-------------ACAA------AATAGCCAGT --------------------------------------ATAAAAAAGAAC---------- -----CTAATGGGTC--------------------------------------------- ------------------------TGAC-AGAGC---TGAAT---------AACAC---- -AATACAAGAA----TTTCACAATGCAATCA-------CAAG------------------ --------------------------------------------TATTAACAGCAGAAT- -----AAACC--AAGC------------------TGAGG---------AAAG-AAT-CTC AGAACTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACTGGTTCTCTGAAA-T--AAGACAG------TCAG---------ACAA--- ------------------AAATAAAGAAAAA---AGA---ATAAAAAGAAA--------- TGA-ACAAAACCTCCAA--GAAGTATGGG-ATTATGTA-----------AAGAG--GCCA AATCTACAAA-TCATTGG--CATCCCTGAAA--------------GGGAGGGGGAGAAAG CAAACAACTTGG---------AAAACATATTTCA--G--------GATATCATCCA-T-G AAAACTTCCCCAACCT--------------------TGCTAGAGAGGCCA--ACAGTCAA ATTC-----AGAAAATACAGAGAAC---TCCTGC-AAGAT--------TCT--------- ---A-CACAAGAA-----GATCATCCCCAA----------------------------GA CACATAATCATCAGATT------TTC-CAAGG---------TCAAAATGA---------- ------------AAG--AAAGAATGT---------------------------------- --------TAAAGGCAGCCAGAGA---GAAAGGGC--------------AGGTCAC---C TAC----------AAAG--------------GGAACCCCAT--CAGGCTAA-C--AGCAG ACC--------TCTCAGCTGAA--ACCCTA-CAAG--CCAG-AAGAGATTG--------- ----GGG-GCCTATA-T-------TCAACT--T-TCT-AAAGAAAAAA------------ -AAA-CT--TCA--ACCAAGAA--------TTTCAT----------ATCCA--------- --GCCAAACTAAGC-----TTCC-TAAGTGA-------AGG-AGAAATAAGATCCTTTTC AGATAAGC-AAATGTTGAGGGA-CTTCATTACCACCAGAC---CTGCCTTAC-AAGAAAT CTT--------------GAAAGA----------------------AGCA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ACACA ----GA------CCAGTGACACT----ATAA-------AGCAACCAC-----ATAAACAA GTCTGCAAAATAACCAGCTAGCATC-------------------------------A--- ------------------------------------------------TGTGACA----- --------------------GGATCAA--ATCC-ACACATAACAATAC------------ -------------TAAC-CTTAAATG-TAAATGGGCT--AAATGC---CCCAATTAAAAG ACACAGAG--TGGCAAGC-TGGAT------------AAAGAACCAAGACCCATTGG---- ---TAT-GCTGTCTTCAAGAG-ACCCATCT-CACAT--GCAAAGACACACATAGGCTCAA AA--TAAAGGGA--TGGAGGA-AAATTTACCAAGCAAATGG------AAAAC-------- -------------AGAAA-AAAGCAA--GGGTTGCAATCCTAGTTTC-TAACAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAAAGAC-AAAG-AAGGGCATTACAT-- ----AATGGTAAA---GGGTTCAATTCAAC--AAGAAG--------AG-CTAACTATCCT AA-----------------ATATATATGCACCCAACACAGGAGCACCCAG--ATTCATAA AGCAAGTTCTTAGAGACCTTCAAAGAGACTTAGACTCCCACAC---------AATAATAG TGGGAGACTTTAACACCCCAC-----TGACAATATTAGACAGA----------------- ----TCATTGAGAC------AGAA-----AATTAACAAAGATATTCAGGACCTG------ --AACTCAGCTCTGGATCAAATGGAC-CTGATAG--ATATCTACAGAA--CTCTCCACCC AAAAACAA---CAGAATATACATTCTTCTCA-------TTGCCACAT---GGCACTTACT C------TAAAATTGATCACATAATCGGAAGTAAAACACT-------------------- -CCTCAGCAAATGCAAAAGAA--CTGAAAT----------------CATAACAA------ -ACAGTCTCTCA---GACCACAGCACAA-TCAAATTAGAACTCAAGACTA--------AG A-------------AA-TTCACTC---AAAACCATACAA----TTACATGGAAATTGAAT AACCTG-CTCCTGAA---TG-ACTTTTG--GGTAA---ATAATGAAAT--TAA-GGCAGA AATCAAGAAGTTCTTT---GAAAC------------------------TAATGAGAACAA -AGATACAAC--ATACCAGAATCTC-TGG-GACACAGCTAAGGCAGTGTTAAGAGGGAAA --TTTATAGCACTAAATGCCCACATCAAAAAGC---TAGA--AAGATCT---CAAGTTAA ------CAACCTAACATCACAACTAAA---AGAACTAGAGAA---CC---AAGAGCAAAC AAATCCCA-AAGCTAGCA------------GAAGACAAGAAATAAC-CAAAATCAGAGCT GAACTG---AAGGAGATAGAGACACAAAAAA-CCA---TTCAAAAGATC-AACAAATCCA -GGAGC-------TGGTTTTTTGAAAAAAATAA--------------------------- -----------------------------------------------------------T AA-----AA------TAGATAGACCA---CTAGCTA------GACT-------------- AATAAAGAAGAAAAG---A---GAGA-AGATTCAAATAAA-------------------- -----CACAA---T---------CAGAAATGATAAG------GGGGA---TATTACCACT G--------ACCC-CACAGAAATA-CAAACAACC--ATCAG---------AGAAT----- -------------------ATTATAAACAC-CTCTATGCACATAA--AC---TAGAAAAT CTAG---AAGAAAT--GGATAAATTCCT--G---GACACA---------TAC-----ACC CTCCCA------AGACTGAACCAGGAAGAAATTGAATCCCTGAAC--------------- --------AGACCA------A------TAACGAGTTCTGAAAT----TGAGG--CAGTAA -TAAATAGCCTACCAACCAAAAAAAG--CC-CAGGACC--AGACGGATTCACAGCTGAA- TTCTA------------CCAGATGTAC----AAAGAAGAGCTGGTA-CCATTC-----C- ----TACTGAAACTATTCCAA-------AAAATTG-AAAAGGAGGG-----------ACT CCTCCCTAACTCATTCTATGAG---------GCCAGCAT---CATCCTGATACC--AAAA C-----------------------CTGGC--AGAGATA-CAAC----AA---------AA AAAGAAAACT---------------------TCA------GGCCAATAT--CCT----TG ATGAACATTGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTGGC-AAACCA------------------AA--T------------ ---C-CA--GGA-------------GCAAAAT---------AAAAAGCTTTTCTA--CCA ----TGAA------------CAAGTAGGCTTTCATCCCCAGGA-TGCAAG---------- -------------GTTGGTTA-AAC-----ATATGC----AAATAAATAAATGTGATATT CATCAC---------A------TAAACAG----AACTAAAGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAGG---CTTTCGATAA---AA TTCAACATCCCTT-------------------CATGT---------T-AAAAAC-TCTCA --ATAAACTAGGTATTGAAGGAACAT-----ACCTCAAAATAAT---------------- -----------AAGAGCCAT-ATAT-GACAAACCCACAGC-----------CAACAT--C ATACTGAATGGGCAAAA-G-----CTGGAAGC-ATTC---CCCTTGAAAA----CCGGCA CAAGACAAGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTATT---GGAAG TTCTGGCCAG--------AGCAATCAG------GCAAGAG---AAAGA--AATAAAGGAC ATTCAAATAGGAAG-------AGAGGAAGTCAAA--CTATCTCTG-----TTTGCAGATG AC--ATGATCCTA-------TATCTAGAAAACCCC---------------ATCGT---CT CAGCCC---------AAA--AGCTTCTTAAGCT---------GATAAA--CAACTTCAGC AAAG--TC-------------------------TCAGGATACAA--------------AA TCAATGT------------GCAAAAAT----TACTAGCATTCC--TA-TACACCAA--CA ACAGTCAAGCCGA------------------GAGCCAAA-TCATG----AATGAACTCCC ATTCACAATTGC-CACAAA---AAGAATAAAATACCTAGGAATAAAACT--------AAC -AAGGGAAGTTGAAAAGCTCTTCAAAAAGAAG--AACTACAAACCACTGCTC-AAAGAAA TCAGAGA-----------TG------------------ACAC--AAAC--AAATGGAAAA ACAT------T---CCATGCTCATG------GATAGGAAGAATC-----AATA-TCATT- ------------------------AAAATGGCCA-TA-TTGCCC-AA------------- ----AGCAATTTATAGA---TTCAATGCTATTCCCATTAAACT---------ACCACTG- AC------------ATTCTT---------------------------------------- --CACAGGACTAG---AAA------AAACTATTTTAAAA-TTCATATGGAA-------CC AAAAAAGA---C---AA--ATAGCCAAGGCAATCCTCAGC---AAGAACA---AAGC--T -------GGAGGCATCATG---CTACCTAACTTCAAACT-----ATACTACAG---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--T-------------------AAA AACAGATA------CATAGACATAAATGGAAGAAAAAAGAGACCAG------AG--AAAT AAG---ACCACACACCTACA----ACTATC--TGATCTTT---GACAAA--CCTGA--CA AAAACAAGC--AATGG-----GGAAAGG----ATTCC--------CTATT--CAATAAAT GGTGCTG----------G-GATAAC--TGG-C-TAGCCA---------------TATGC- AGA---------AAA--TTGAAACTGGACCC-------CCT---------------TATA AC--ACAAACAAAAA-TTAACT-CAAGATGGATTAAAGACTTAAATGTA--AAACCTAAA ACC-AT------------------------AAAAACCCTAGAA----------------- ------GAAC--ACCTA------G---------GCA---------ATACCCTTCAGGAC- --ATA-----GG-CATGGGCAAAGATTTCATGAAAAA-AACACCA-AAA----GCAATTG CAACAAAAGCAAA----A------AT---TGAC--AAA-GGGG---TT--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTATCAAC-AGAG-TAAACAG-ACAAC CTAC--AGAA--T-GGGAG--AAAATTTTT---GCAAACTATGCAT--------CTGACA AAGGTCTAA-------TATCCAGCATCTATA--AGGAA--CTTAA-----ACAAA----- ----------------------TTTACAAGAA------AAAAAC------------A--- AACAACCCCA-TTAAAA----------AGTGGGCAAA-----------GGA--CATGAAC ---AGACACTTCTCAAAAGAAGACATACACG--------------TGGCCAAC-AAACAT ATGAAAAAAAG----CTCAACATCACTGA-TCATTAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACACCAGTCAGAATGGCTA-- ----TTATTAAAA---AGTCAAAAA-----------ACATCAG--ATG--CTGGA-C--- ---------------AGGTTGTGGGGAA-------------------------------- -----AATGGAAAGCTTAA-ACACTGTTGG--TGGGAG---------------------- -------------TTTAAAGTGGTTGTACCAATTA-GTTCAACC--------ATTGTGG- -------AAGACA-GTGTGGTGATATTT-CTAAGAGATCTAAAA--ACAGAAATACCA-- -TTTGA--CCCAGCAATCCCATTACTGGG-TATATA-CCCAAAGG-AAT--ATAA----- -------------------ATTATTCT-ATTAT--AAAGACACATG----------C--- ---------ACGCA--TATGTTCATTGCAGCACTATT---CACAATA-GCAAAGACAT-G GA--ATCA--ACCCAAA-TGCCCATCA---ATGATAG-----ACTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AAGAATGAGATCATGTCCTTT----------- ------------------------------------------------------------ -GCAGGGACATGGATGGAG-C---T----------------GGAGGCCATTATCCTTAGC AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------ACACA--GGAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAA---- -----------------------------CCAAATAC-CGCATG--------TTC----- ------TCACT---TAT------------------------AAGTGGGAGC---CTAAAT G-------A--------------TGAGAA---------------C--------------- ------------------------------------ACATG-------------GACA-- -------CA------------------------------------------TAGAGG--- -GGAACAACACA---CACTG-----GGGCCTATC---------GGAGGG----------- TGG-AGGGTGGG------------------------------------------------ --AGG-------AGGGAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGG----------ATCAG-GAAAAATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ACTAATG---------------------------------------------- --------GATA----CTAGGCTT----------------------AATACCTGGGT--G ATGAAA--------------------------------------TAATCTGT-------A CAA-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCCCCATG-- -------------------ACACA-CGTTTA--------C-------------CTATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA-----AACCTGCAC----------------------------------------- ------ATCC-TGCACA-------------------------------TGTACC------ ------------------------------------------------------------ -------------------------------------------------CCT-------- --------------GAACT------------TAAAATA----AAAGTTA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA7 --------------------------GGTGGCTGGCAAGATG--GCCGAAT-AGGAACAG CTCCGGTCTGC---AGCTCCCA--------GCGAGATCAACG------------------ ---------------------CAGA----------AGGCGGGTGATTTC--------TGC AT--TTCCAACTG-A-----GGTACCCGGCTCATCTCATTGGGA-----------CTGGT TAGA---CAGTGGGT--GCA--------------G--------------CCCACGGAGGG C---------------------GAGCCGAAGCAGGGTGGGGCGTCG-------------- ------------CCTCACCCG-----------------GG--AAGC--GCAAGGGGTCG- -------------GGGA---A-CTCCCTCC----CCTAG-----CCA-----AG-GGAAG CCGTGAGGGACTGTGC------CGTGAGGAACGGTGCATTCCGG-CCCAGATACTACGCT T-------------------------TTCCCACGG-TCTTCGCAACCCGC----AGACCA GGAGAT-TCCCTCGGGTG---CCT------------------------------------ ---ACACCACCAGGGCCCTGGGTTTCAAGCAC------------------AAAACTGGGC GGCCGTTTGGGCAGACACCGA---------GCTAGCTGCAGGA------GTTTTTT---- ------------TTCATACCCCAGTGGC--GCCTGGAACGCCAGC--------------- ----------------GAGACAGAACCGTTCACTCCCCTG----GAA------------- --AGGGGGCTGAA------------GCCAGGGAGCCAAGTGGTCTAGCTCAGCGG----- -----ATCCCACCC-CCACGGAGC-------CCAGCAAGCTAAGAT-------------- ---CCACTGGCTTGAAATTCTCGCT-GCCAGC--------------A-----CAG----- ------------------------------------CAGTCTGAAGT------------- -------------------CGACCTGGGA-CGCTCGA--G-----CTTG----------- -GTGGGGGG------AGGGGC-------------------GTCCGCCATTACTGAGG--- -----------------------------------------CTT--GAGTAGGCGGTTTT CCCCTCACAGTGTAAACAAAGCCGCCGGG--------------AAGTTCGAACTGG---- -------------------GCGGAGCCCACCGCAG----------------CTCGGCAAA GC-------------CGCT--------------GTAGCC--------------------- -------AGACTG---------------CCTCTCTAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ATTCCTCCTCTCTGG-----------------------GCA GG-GCATCTCT-------------------------------GAAA-GA----------- --------------------------------------AAGGCAGCA------------- -GCCCCAGTCAGGGGCTTATA---GATAAAACTCCC------------------A--TCT CCCTG--------------------GGACAGAG------------------CACC----- -------TGGGGGAAGGGGCGG-----CTGTGGGCGCAGC-------------------- TTCA--------GCAGAC------------------------------------------ -TTAAACGT------TCCTGCC--TGCCGGCTCTGAAGA--------------------- ---------G-A-----GCAGCG--------------GA----------------TCTCC CAG----------------------CACAGCGCTCGAGCTCTGCTAAGGG--------A- ---C--------AGACTGC--------CTCCTCAA---------------------GTGG GT-------CC---CTGACCCCC-----GT-----GCCTCCTG---------------AC TGGGAGACAC--CTCCCA---------------GCAGGG------GTCG----------- -----------A-------------------------CAGACACCTCAT----------- -----ACAGGAGAGCTCCGGCTGGCATCT-------GGCGGG------------------ ------TGCCCCTCTGGGACGAAGCT---------------------------------- ----------------------------------------------TCCA---------- -----------GAGGAAGGAA--CAGG----------------------------CAGCA ATCTTT-----------------G------------------CTGTTCTGCAGC--CTCC GCTGGTGAT----------ACC-------------------CAGGCAAACA--------- ------------G-GGTCTGGAG------------------------TGGACC---TCCA GCAAA-------------CTCCA---------GCAG------------------------ -------------------------------------------A--CCTGCAGCAGAG-- -----------GGGCCTGACTGTTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAAGGAA------------------------------AAC T-----------AACAAACAGAAA------------------------------------ --------------------------------------------------G--------- ---------GAATAGCATCAACAT--------CAACAAAAAGGACGTCCACAC------- ------------------------------------------------------------ -----------AAAAACCC----------------------CAT---------------- -----------CCGAAGGTCACC------------------------------------- --AACATCAA-AGACCAAA--------------G-------------------------- ---GTAGATAA------ATCC--------------------------------------- ------------------------AC-------GAAGTGAGGAA---------------- ------AAACCAGC-------GCAAAAAGGCT-------GAAAATTCCAAAAACCAGAAC GCCTCTTCTCCTC-----CAA------------AGGATCACAACTCCTCG---------- CCAG---CAAGGGAACAAA-------ACT-GGACGGAGAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-GTTTGACG AATT------GACAGAAG------TAGGC------------TTCAGAAG---GTGGGT-A ATAACAA---ACTCCTCCGAGCT----AAAGGAGCATG---------------------- ------------------------------TTCTAACCCAATGC---AAGGAAGC----- ----------------------------------------T------------------- -------AAGAACCTTGAAAAAAGG---TTAGAGGAATT--------------------- ----------------------GCTAA-------------CTAG------AATAACCAGT --------------------------------------TTAGAGAAGAAC---------- -----ATAAATGACC--------------------------------------------- ------------------------TGAT-GGAGC---TGAAA---------AACAC---- -AGCACGAGAA----CTTCGTGAAGCATACA-------CAAG------------------ --------------------------------------------TATCAATAGCCGAAT- -----CGATC--AAGC------------------GGAAG---------AAAG-GAT-ATC AGAGATT----------------------------------------------------- ------------------------------------------------------------ ----GAAGATCAACTTAATGAAA-T--AAAGCGT------GAAG---------ACAA--- ------------------GATTAGAGAAAAA---AGA---ATGAAAAGGAA--------- CGA-ACAAAGCCTCCAA--GAAATATGGG-ACTATGTG-----------AAAAG--ACCA AACCTACGTT-TGATTGG--TGTACCTGAAA--------------GTGACGGGGAGAATG GAACCAAGTTGG---------AAAACACTCTTCA--G--------GATATTATCCA-G-G AGAACTTCCCCAACCT--------------------AGCAAGACAGGCCA--ACATTCAA ATTC-----AGGAAATACAGAGAAC---ACCACA-AAGAT--------ACT--------- ---C-CTCGAGAA-----GAGCAACCCCAA----------------------------GA CACATAATCGTCAGATT------CAC-CAAGG---------TTGAAATGA---------- ------------AGG--AAAAAATGT---------------------------------- --------TAAGGGCAGCCAGAGA---GAAAGGTC--------------GGGTTAC---C CAC----------AAAG--------------GGAAGCCCAT--CAGACTAA-C--AGCGG ATC--------TCTCTGCAGAA--ACCCTA-CAAG--CCAG-AAGAGAGTG--------- ----GGG-GCCAATA-T-------TCAACA--T-TCT-TAAAGAAAAG------------ -AAT-TT--TCA--ACCCAGAA--------TTTCAT----------ATCCA--------- --GCCAAACTAAGC-----TTCA-TAAGCGA-------AGG-AGAAATAAAATCCTTTAC AGACAAGC-AAATGCTGAGAGA-TTTTGTCACCACCAGGC---CTGCCTTAC-AAGAGCT CCT--------------GAAGGA----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------AAACCGGTACCAGC CACTGC------AAAAACATACC------A---------------AATT-----GGTAAA ----GA------CCATCGACACT----ATGA-------AGAAACTGC-----ATCAACTA ACGGGCAAAATAACCAGCTAGCATC-------------------------------A--- ------------------------------------------------TATGACA----- --------------------GGATCAA--ATTC-ACACATAACAATAT------------ -------------TAAC-CTTAAATG-TAAATGGGCT--AAATGC---CCCAATTAAAAG ACACAGAC--TGGCAAAT-TGGAT------------AAAGAGTCAAGACCCATCGG---- ---TGT-GCTGTATTCAGGAG-ACCCATCT-CACGT--GCAAAGACACACATAGGCTCAA AA--TAAAGGGA--TGGAGGA-ATATTTACCAAGCAAATGG------AAAGC------AA AAAAAAAAAAAAAAAAAA-AAAGCAG--GGGTTGCAATCCTAGTCTC-TGATAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAAAGAC-AAAG-AAGGGCATTACAT-- ----AATGGTAAA---GGGATCAATGCAAC--AAGAAG--------AG-CTAACTATCCT AA-----------------ATATATATGCACCCAATACAGGAGCACCCAG--ATTCATAA AGCAAGTTCTTAGAGACCTACAAAGAGACTTAGACTCCCACAC---------AATAATAG TGGGAGACTTTAACACCCCAC-----TGTCAATATTAGACAGA----------------- ----TCAACGAGAC------AGAA-----AATTAACAAGGATATTCAGGACTTG------ --AACTCAGCTCTGGACCAAGCGGAC-CTAATAG--ACATCTACAGAA--CTCTCCACCC CAAATCAA---CAGAATATACATTCTTCTCA-------GCACCACAT---CGCACTTATT C------TAAAATTGACCACATAATTGGAAGTAAAACACT-------------------- -CCTCAGCAAATGCAAAAGAA--CGGAAAT----------------CATAACAA------ -ACAGTCTCTCA---GACCACAGTGCAA-TCAAATTAGAACTCAGGATTA--------AG A-------------AA-CTCACTC---AAAACCGCACAA----CTACATGGAAACTGAAC AACCTG-CTCCTGAA---TG-ACTACTG--GGTAA---ATAACGAAAT--TAA-GGCAGA AATAAATAAGTTCTTT---GAAAC------------------------CAATGAGAACAA -AGACACAAC--GTACCAGAATCTC-TGG-GACACAGCTAAAGCAGTGTTTAGAGGGAAA --TTTATAGCACTAAATGCCCACAGGAGAAAGC---GGGA--AAGATCT---AAAATCGA ------CACCCTAACATCACAATTAAA---AGAACTAGAGAA---GC---AAGAGCAAAC AAATTCAA-AAGCTAGCA------------GAAGACAAGAAATAAC-TAAGATCAGAGCA GAACTG---AAGGAGATAGAGACACAAAAAA-CCCCCTTTAAAAAAATC-AATGAATCCA -GGAGC-------TGGTTTTTTGAAAAGATTAA--------------------------- -----------------------------------------------------------C AA-----AA------TAGATAGACCG---CTAGCCA------GACT-------------- AATAAAGAAGAAAAG---A---GAGA-AGAATCAAATAGA-------------------- -----CACAA---T---------AAAAAATGATAAA------GGGGA---TATCACCACT G--------ATCC-CACAGAAATA-CAAACTACC--ATCAG---------AGAAT----- -------------------ACTATAAACAC-CTCTATGCAAATAA--AC---TAGAAAAT CTAG---AAGAAAT--GGATAAATTCCT--G---GACACA---------TAC-----ACC CTCCCA------AGACTAAACCAGGAAGAAGTCGAATCCCTGAAT--------------- --------AGACCA------A------TAACAAGTTCTGAAAT----TGAGG--CAGTAA -TTAATAGCCTACCAACCAAAAAAAG--CC-CAGGACC--AGACGGATTCACAGCCGAA- TTCTA------------CCAGAGGTAC----AAAGAGGAGCTGGTA-CCATTC-----C- ----TTCTGAAACTATTCCAA-------ACAATAG-AAAAAGAGGG-----------ACT CCTCCCTAACTCATTTTATGAG---------GCCAGCAT---CATCCTGATACC--AAAA C-----------------------CTGGC--AGAGACA-CAAC----AA---------AA AAAGAAAATT---------------------TCA------GGCCAATAT--CCC----TG ATGAACATCGAT------------------------GCGAAAATCC-TCAA--------- ------TAAAATACTGGC-AAACCG------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGCTTATCCA--CCA ----CGAT------------CAAGTCGGC-TTCATCCCTGGGA-TGCAAG---------- -------------GCTGGTTC-AAC-----ATACGC----AAATCAATAAACGTA--ATC CATCAC---------A------TAAACAG----AACCAATGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAGG---CCTTCGATAA---AA TTCAACACCCCTT-------------------CATGC---------T-AAAAAC-TCTCA --ATAAACTAGGTATTGATGGAACGT-----ATCTCAAAATAAT---------------- -----------AAGAGCTAT-TTAT-GACAAACCCACAGC-----------CAATAT--C ATACTGAATGGGCAAAA-G-----CTGGAAGC-ATTC---CCTTTGAAAA----CCGGCA CAAGACAAGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTATT---GGAAG TTCTGGCCAG--------GGCAATCAG------GCAAGAG---AAAGA--AATAAAGGGT ATTCAAATAGGAAG-------AGAGGAAGTCAAA--TTGTCTCTG-----TTTGCAGATG AC--ATGATTGTA-------TATTTAGAAAACCCC---------------ATCGT---CT CAGCCC---------AAA--ATCTCCTTAAGCT---------GATAAG--CAACTTCAGC AAAG--TC-------------------------TCAGGATACAA--------------AA TCAATGT------------GCAAAAAT----CACAAGCATTCC--TA-TACACCAA--TA ATAGACAAACAGA------------------GAGCCAAA-TCATG----AGTGAACTCCC ATTCACAATTGC-TACAAA---GAGAATAAAATACCTAGGAATACAACT--------TAC -AAGGGATGTGAAGGACCTCT---TCAAGGAG--AACTACAAACCACTGCTC-AAGGAAA TAAGAGA-----------GG------------------ACAC--AAAC--AAATGGAAAA ACAT------T---CCATGCTCATG------GATAGGAAGAATC-----AATA-TCGTG- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----AGTAATTTATAGA---TTCAATGCTATCCCCATCAAGCT---------ACCATTG- AC------------TTTCTT---------------------------------------- --CACAGAATTAG---AAA------AAACTACTTTAAAT-TTCATATGGAA-------CC AAAAAAGAGCCC---GT--ATAGCCAAGACAATCCTAAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACG---CTACCTGACTTCAAACT-----ATACTACAA---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CCAA AACAGATA------TATAGAC--CAATGGAACAGAACAGAGGCCTC------AG--AAAT AAC---GCCACACATCTACA----ACCATC--TGATCTTT---GACAAA--CCTGA--CA AAAACAAGC--AATGG-----GGAAAGG----ATTCC--------CTATT--TAATAAAT GGTGTTG----------G-GAAAAC--TGG-C-TAGCCA---------------TATGC- AGA---------AAA--CTGAAACTGGACCCCT----TCCT---------------TACA CC--TTATACAAAAA-TTAACT-CAAGATGGATTAAAGACTTAAACGTA--AGACCTAAA ACC-AT------------------------AAAAACCCTAGAA----------------- ------GAAA--ACCTA------G---------GCA---------ATACCATTCAGGAC- --ATA-----GG-CATGGGCAAAGACTTCATGACTAA-AACACCA-AAA----GCAATGG CAACAAAAGCCAA----A------AT---TGAC--AAA-TGGGATCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTATCATC-AGAG-TGAACAG-GCAAC CTAC--AGAA--T-GGGAG--AAAATTTTT---GCAATCTATCCAT--------CTGACA AAGGGCTAA-------TATCCAGAATCTACA--AGGAA--CTTAA-----ACAAA----- ----------------------TTTACAAGAA------AAAAAC------------A--- AACAACCCCA-TCAAAA----------AGTGGGCGAA-----------GGA--TATGAAC ---AGACACTTCTCAAAAGAAGACATTTATG--------------CGGCCAAC-AAACAT ATGAAAAAAAG----CTCATCATCACTGG-TCATTAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACGCCAGTTAGAATGGCGA-- ----TCATTAAAA---AGTCAGGAA-----------ACAACAG--ATG--CTGGA-G--- ---------------AGGATGTGGAGAA-------------------------------- -----ATAGGAACGCTTTT-ACACTGTTGG--TGGGAG---------------------- -------------TGTA-------------AATTA-GTTCAACC--------ATTGTGG- -------AAGACA-GTGTGGCG--ATTC-CTCAAGGATCTAGAA--CCAGAAATACCA-- -TTTGA--CCCAGCAATCCCATTACTGGG-TATATA-CCCAAAGG-ATT--ATAA----- -------------------ATCATTCT-ACTAT--AAAGACACATG----------C--- ---------ACACG--TATGTTTATTGCAGCACTGTT---CACAATA-GCAAAGACTT-G GA--ACCA--ACCCAAA-TGCCCATCA---ATGATAG-----ACTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGCACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AAGGATGAGTTCATGTCCTTT----------- ------------------------------------------------------------ -GCAGGGACATGGATGAAG-C---T----------------GGAAACCATCATTCTCAGC AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------ACACA--GGAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAA---- -----------------------------CCAAACAC-CGCATG--------TTC----- ------TCACT---CAT------------------------AAGTGGGAGT---TTGAAC A-------A--------------TGAGAA---------------C--------------- ------------------------------------ACATG-------------GACA-- -------CA------------------------------------------GGGAGG--- -GGAACATCACA---CACCG-----GGGCCTGTC---------GGGGGG----------- TGG-GGGGCTAG------------------------------------------------ --GGG-------AGGGAT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGC----------ATTAG-GAGAAATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CCTAATG---------------------------------------------- ----------------------------------------------------TAGAT--G ACGGGT--------------------------------------TGATGGGT-------G CAG-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCACCATG-- -------------------GCACG-TGTATA--------C-------------CTATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA-----AACCTGCAC----------------------------------------- ------GTTC-TGCACA-------------------------------TGTATC------ ------------------------------------------------------------ -------------------------------------------------CCA-------- --------------GAACT------------TAAAGTA----TAATAATAA------AA- -------AAAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA8 --------------------------------TGGCAAGATG--GCCGAAT-AGGAACAG CTCCGGTCTGC---AGCTCCCA--------GCGAGACCAATG------------------ ---------------------CAGA----------AGGCGGGTGATTTC--------TGC AT--TTCCAACTG-A-----GGTACCCAGTTCATCTCATTGGGA-----------CTGGT TAGG---CAGTGGGT--GCA--------------G--------------CCCACGGAGGG C---------------------GAGCAGAAGCAGGGTGGGGCGTCG-------------- ------------CCTCACCCA-----------------GG--AAGT--GCAAGGAGCCG- -------------GGGG---A-CTCCCTTC----CCCAG-----CCA-----AG-GGAAG CCGTGAGGGACTGTGC------TA---------------TCCGG-CCTAGGTACTACGCT T-------------------------TTCCCACGG-TTTTTGCAATCCGC----AGATCA GGAGAT-TCCCTCGTGTG---CCT------------------------------------ ---ACACCACCAGGGCCCTGGGTTTCAAGCAC------------------AAAACTGGGC GGCTGTTTGGGCAGACACCGA---------GCTAGCTGGGGGATTTTTTTTTTTTT---- ------------TTCGTACCCCAGTGGC--GCCTGGAACCCCAGC--------------- ----------------GAGACAGAACCGTTCACTCCCCTG----GAA------------- --AGGGGGCTGAA------------GCCAGGGAGCCAAGTGGTCTCGCTCAGCGG----- -----GTCCCACTC-CCACGGAGC-------CCAGCAAGCTAAGAA-------------- ---CCACTGGCTTGAAATTCTCGCT-GCCAGC--------------A-----CAG----- ------------------------------------CAGTCTGAAGT------------- -------------------CGACCTGGGA-CGATCGA--G-----CTTG----------- -GTGGGGGG------AGGGGC-------------------GTCCGCCATTACTGAGG--- -----------------------------------------CTT--GAGTAGGCGGTTTT CCCCTGACAGTGC---TAAGGAGGCTGGG--------------AGGTTTGGACTGG---- -------------------GCGGAACTCACCACAG----------------CGTGGCAAA GC-------------GGCT--------------GTGGCC--------------------- -------AGACTG---------------CCTCTCTAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ATTCCTCCTCACTGG-----------------------GCA GG-GCATCTCT-------------------------------GAAA-GA----------- --------------------------------------AAGGCAGCA------------- -GCCCCAGTCAGGGGCTTATA---GATAAAACTCCC------------------A--TCT CCCTG--------------------GGACAGAG------------------CACC----- -------TGGGGGAAGGGGCGG-----CTGTGGGCGCAGC-------------------- TTCA--------GCGGAC------------------------------------------ -TTAAACGT------TCCTGCC--TGCCGGCTCTGAAGA--------------------- ---------G-A-----GCAGCG--------------GATCCTGACAAGGAGGATTCTCC CAG----------------------CACAGCGCTCGAGCTCTGCTAAGGG--------A- ---C--------AGACTGC--------CTCCTCAA---------------------GTGG GT-------CC---CTGACCCCC-----GT-----GCCTCCTG---------------AC TGGGAGAGAC--CTCCCA---------------ACAGGG------GTCG----------- -----------A-------------------------CAGACACCTCAT----------- -----ACAGGAGAGCTCCGGCTGGCATCA-------GGCCGG------------------ ------TGCCCCTCTGGGACGAAGCT---------------------------------- ----------------------------------------------TCCA---------- -----------GAGGAAGGAG--CAGG----------------------------CAGCA ATCTTT-----------------G------------------CTGTTCTGCAGC--CTCC GCTGGTGAT----------ACC-------------------CAGGCAAACA--------- ------------G-GGTCTGGAG------------------------TGGACC---TCCA GCAAA-------------CTGCA---------GCAG------------------------ -------------------------------------------A--CCTGCAGAAGAG-- -----------GGGCCTGACTGTTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAAGAAA------------------------------AAC T-----------AACAAACAGAAA------------------------------------ --------------------------------------------------G--------- ---------CAATAACATCAACAT--------CAACAAAAAGGACCCCCACAC------- ------------------------------------------------------------ -----------AAAAACCC----------------------CAT---------------- -----------CCAAAGGTCATC------------------------------------- --AGCCTCAA-AGATCAAA--------------G-------------------------- ---GTAGATAA------ATCC--------------------------------------- ------------------------AC-------GAAGTGAGGAA---------------- ------AAACCAGC-------GCAAAAATGCT-------GAAAATTCCAAAAACCAGAAT GCCTCTTCTCCTC-----CAA------------ATGATCGCAACTCCTCT---------- CCAG---CAAGGGCACAAA-------ACT-GGATGGAGAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-GTTTGACG AATT------GACAGAAG------TAGGC------------TTCAGAAG---GTGGGT-A ATAACAA---ACTCCTCTGAGCT----AAAGGAGCATG---------------------- ------------------------------TTCTAACCCAATGC---AAGGAAGC----- ----------------------------------------T------------------- -------AAGAACCTTGATAAAAGG---TTACAGGAACT--------------------- ----------------------GCTAA-------------CTAG------AATAACCAGT --------------------------------------TTAGAGAAGAAC---------- -----ATAAATGACC--------------------------------------------- ------------------------TGAT-GGAGC---TGAAA---------AACAC---- -AGCACGAGAA----CTTCGTGAAGCATACA-------CAAG------------------ --------------------------------------------TATCAATAGCCGAAT- -----CGATC--AAGC------------------GGAAG---------AAAG-GAT-ATC AGAGATT----------------------------------------------------- ------------------------------------------------------------ ----GAAGATCAACTTAATGAAA-T--AAAGCGT------GAAG---------ACAA--- ------------------GATTAGAGAAAAA---AGA---ATGAAAAGGAA--------- CGA-ACAAAGCCTCCAA--GAAATATGGG-ACTATGTG-----------AAAAG--ACCA AACCTACGAT-TGATTGG--TGTACCTGAAA--------------GTGACGGGGAGAATG GAACCAAGTTGG---------AAAACACACTTCA--G--------GATATTATCCA-G-G AGAACTTCCCCAACCT--------------------AGCAAGACAGGCCA--ACATTCAA ATTC-----AGGAAATACAGAGAAC---ACCACT-AAGAT--------ACT--------- ---C-CTCAAGAA-----GAGCAACCCCAA----------------------------GA CACATAATCGTCAGATT------CTC-CAAGG---------TTGAAATGA---------- ------------AGG--AAAAAATGT---------------------------------- --------TAAGGGCAGCCAGAGA---GAAAGGTC--------------AGGTTAC---C TAC----------AAAG--------------GGAAGCCCAT--CAGACTAA-C--AGCGG ATC--------TCTCTGCAGAA--ACCCTA-CAAG--CCAG-AAGAGAGTG--------- ----GGG-GCCAATA-T-------TCAACA--T-TCT-TAAAGAAAAG------------ -AAT-TT--TCA--ACCCAGAA--------TTTCAT----------ATCCA--------- --GCCAAACTAAGC-----TTCA-TAAGCGA-------AGG-AGAAATAAAATCCTTTAC AGACAAGC-AAATGCTGAGGGA-TTTTGTCACCACCAGGC---CTGCCTTAC-AAGAGCT CCT--------------GAAGGA----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------AAACCGGTACCAGC CACTGC------AAAAACATACC------A---------------AAAT-----AATAAA ----GA------CCAATGACACT----ATGA-------AGAAACTGC-----ATCAACTA ATGTGCAAAATAACCAGCTAGCATC-------------------------------A--- ------------------------------------------------TGTGACA----- --------------------GGATCAA--ATTC-ACACATAACAATAT------------ -------------TAAC-CTTAAATG-TAAATGGGCT--AAATGC---CCCAATTAAAAG ACACAGAC--TGGCAAAT-TGGAT------------AAAGAGTCAAGACCCATCGG---- ---TGT-GCTGTATTCAGGAG-ACCCATCT-CACGT--GCAAAGACACACATAGGCTCAA AA--TAAAGGGA--TGGAGGA-ATATTTACCAAGCAAATGG------AAAGC-------- ----------AAAAAAAA-AAAGCAG--GGGTTGCAATCCTAGTCTC-TGATAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAAAGAC-AAAG-AAGGGCATTACAT-- ----AATGGTAAA---GGGATCAATGCAAC--AAGAAG--------AG-CTAACTATCCT AA-----------------ATATATATGCACCCAATACAGGAGCACCCAG--ATTCATAA AACAAGTTCTTAGAGACCTACAAAGAGACTTAGACTCCCACAC---------AATAATAG TGGGAGACTTTAACACCCCAC-----TGTCAATATTAGACAGA----------------- ----TCAACGAGAC------AGAA-----AATTAACAAGGATATTCAGGACTTG------ --AACTCAGCTCTGGACCAAGCGGAC-CTAATAG--ACATCTACAGAA--CTCTCCACCC CAAATCAA---CAGAATATACATTCTTCTCA-------GCACCACAT---AGCACTTATT C------TAAAATCGACCACATAATTGGAAGTAAAACACT-------------------- -CCTCAGCAAATGCAAAAGAA--CGGAAAT----------------CATAACAA------ -ACAGTCTCTCA---GACCACAGTGCAA-TCAAATTAGAACTCAGGATTA--------AG A-------------AA-CTCACTC---AAAACCGCACAA----CTACATGGAAACTGAAC AACCTG-CTCCTGAA---TG-ACTACTG--GGTAA---ATAACGAAAT--TAA-GGCAGA AATAAAGAAGTTCTTT---GAAAC------------------------CAATGAGAACAA -AGACACAAC--GTACCAGAATCTC-TGG-GACACAGCTAAAGCAGTGTTAAGAGGGAAA --TTTATAGCACTAAATGCCCACATCAGAAAGC---GGGA--AAGATCT---AAAATCGA ------CACCCTAACATCACAATTAAA---AGAACTAGAGAA---GC---AAGAGCAAAC AAATTCAA-AAGCTAGCA------------GAAGACAAGAAATAAC-TAAGATCAGAGCA GAACTG---AAGGAGATAGAGACACGAAAAA-CCC---TTCAAAAAATC-AATGAATCCA -GGAGC-------TGGTTTTTTGAAAAGATTAA--------------------------- -----------------------------------------------------------C AA-----AA------TAGATAGACCG---CTAGCCA------GACT-------------- AATAAAGAAGAAAAG---A---GAGA-AGAATCAAATAGA-------------------- -----CACAA---T---------AAAAAATGATAAA------GGGGA---TATCACCACT G--------ATCC-CACAGAAATA-CAAACTACC--ATCAG---------AGAAT----- -------------------ACTATAAACAC-CTCTACGCAAATAA--AC---TAGAAAAT CTAG---AAGAAAT--GGATAAATTCCT--G---GACACA---------TAC-----ACC CTCCCA------AGACTAAACCAGGAAGAAGTCGAATCCCTGAAT--------------- --------AGACCA------A------TAACAAGTTCTGAAAT----TGAGG--CAGTAA -TTAATAGCCTACCAACCAAAAAAAG--CC-CAGGACC--AGACGGATTCACAGCCGAA- TTCTA------------CCAGAGGTAC----AAAGAGGAGCTGGTA-CCATTC-----C- ----TTCTGAAACTATTCCAA-------ACAATAG-AAAAAGAGGG-----------ACT CCTCCCTAACTCATTTTATGAG---------GCCAGCAT---CATCCTGATACC--AAAA C-----------------------CTGGC--AGAGACA-CAAC----AA---------AA AAAGAAAATT---------------------TCA------GGCCAATAT--CCC----TG ATGAACATCGAT------------------------GCGAAAATCC-TCAA--------- ------TAAAATACTGGC-AAACCG------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGCTTATCCA--CCA ----CGAT------------CAAGTCGGC-TTCATCCCTGGGA-TGCAAG---------- -------------GCTGGTTC-AAC-----ATATGC----AAATCAATAAACGTA--ATC CATCAC---------A------TAAACAG----AACCAATGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAGG---CCTTCGATAA---AA TTCAACACCCCTT-------------------CATGC---------T-AAAAAC-TCTCA --ATAAACTAGGTATTGATGGAACAT-----ATCTCAAAATAAT---------------- -----------AAGAGCTAT-TTAT-GACAAACCCATAGC-----------CAATAT--C ATACTGAATGGGCAAAA-G-----CTGGAAGC-ATTC---CCTTTGAAAA----CCGGCA CAAGACAAGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTATT---GGAAG TTCTGGCCAG--------GGCAATCAG------GCAAGAG---AAAGA--AATAAAGGGT ATTCAAATAGGAAG-------AGAGGAAGTCAAA--TTGTCTCTG-----TTTGCAGATG AC--ATGATTGTA-------TATTTAGAAAACCCC---------------ATCGT---CT CAGCCC---------AAA--AACTCCTTAAGCT---------GATAAG--CAACTTCAGC AAAG--TC-------------------------TCAGGATACAA--------------AA TCAATGT------------GCAAAAAT----CACAAGCATTCC--TA-TACACCAA--TA ATAGACAAGCAGA------------------GAGCCAAA-TCATG----AGTGAACTCCC ATTCACAATTGC-TACAAA---GAGAATAAAATACCTAGGAATACAACT--------TAC -AAGGGATGTGAAGGACCTCT---TCAAGGAG--AACTACAAACCACTGCTC-AAGGAAA TAAGAGA-----------GG------------------ACAC--AAAC--AAATGGAAAA ACAT------T---CCATGCTCATG------GATAGGAAGAATC-----AATA-TCGTG- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----AGTAATTTATAGA---TTCAATGCTATTCCCATCAAGCT---------ACCATTG- AC------------TTTCTT---------------------------------------- --CACAGAATTAG---AAA------AAACTACTTTAAAT-TTCATATGGAA-------CC AAAAAAGAGCCC---GT--ATAGCCAAGACAATCCTAAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACG---CTACCTGACTTCAAACT-----ATACTACAA---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CCAA AACAGATA------TATAGAC--CAATGGAACAGAACAGAGGCCTC------AG--AAAT AAC---ACCACACATCTACA----ACCATC--TGATCTTC---GACAAA--CCTGA--CA AAAACAAGC--AATGG-----GGAAAGG----ATTCC--------CTATT--TAATAAAT GGTGCTG----------G-GAAAAC--TGG-C-TAGCCA---------------TATGC- AGA---------AAA--CTGAAACTGGACCCCT----TCCT---------------TACA CC--TTATACAAAAA-TTAACT-CAAGATGGATTAAAGACTTAAATGTA--AAACCTAAA ACC-AT------------------------AAAAACCCTAGAA----------------- ------GAAA--ACCTA------G---------GCA---------ATACCATTCAGGAC- --ATA-----GG-CATGGGCAAAGACTTCATGACTAA-AACACCA-AAA----GCAATTG CAACAAAAGCCAA----A------AT---TGAC--AAA-TGGGATCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTATCATC-AGAG-TGAACAG-GCAAC CTAC--AGAA--T-GGGAG--AAAATTTTT---GCAATCTATCCAT--------CTGACA AAGGTCTAA-------TATCCAGAATCTACA--AGGAA--CTTAA-----ACAAA----- ----------------------TTTACAAGAA------AAAAAC------------A--- AACAACCCCA-TCAAAA----------AGTGGGCGAA-----------GGA--TATGAAC ---AGACACTTCTCAAAAGAAGACATTTATG--------------CGGCCAAC-AAACAT ATGAAAAAAAG----CTCATCATCACTGG-TCATTAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACGCCAGTTAGAATGGCGA-- ----TCATTAAAA---AGTCAGGAA-----------ACAACAG--ATG--CTGGA-G--- ---------------AGGATGTGGAGAA-------------------------------- -----ATAGGAACGCTTTT-ACACTGTTGG--TGGGAG---------------------- -------------TGTA-------------AATTA-GTTCAACC--------ATTGTGG- -------AAGACA-GTGTGGCG--ATTC-CTCAAGGATCTAGAA--CCAGAAATACCA-- -TTTGA--CCCAGCAATCCCATTACTGGG-TATATA-CCCAAAGG-ATT--ATAA----- -------------------ATCATTCT-ACTAT--AAAGACACATG----------C--- ---------ACACG--TATGTTTATTGCAGCACTATT---TACAATA-GCAAAGACTT-G GA--ACCA--ACCCAAA-TGCCCATCA---ATGATAG-----ACTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGCACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AAGAATGAGTTCATGTCCTTT----------- ------------------------------------------------------------ -GCAGGGACATGGATGAAG-C---T----------------GGAAACCATCATTCTCAGC AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------ACACA--GGAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAA---- -----------------------------CCAAACAC-CGCATG--------TTC----- ------TCACT---CAT------------------------AAGTGGGAGT---TTGAAC A-------A--------------TGAGAA---------------C--------------- ------------------------------------ACATG-------------GACA-- -------CA------------------------------------------GGGAGG--- -GGAACATCACA---CACCG-----GGGCCTGTC---------GGGGGG----------- TGG-GGGGCAAG------------------------------------------------ --GGG-------AGGGAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGC----------ATTAG-GACAAATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CCTAATG---------------------------------------------- --------CATG----CGGGGCTT----------------------AAAACCTAGAT--G ACGGGT--------------------------------------TGATAGGT-------G CAG-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCACCATG-- -------------------GCACA-TGTATA--------C-------------CTATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA-----AACCTGCAC----------------------------------------- ------GTTC-TGCACA-------------------------------TGTATC------ ------------------------------------------------------------ -------------------------------------------------CCA-------- --------------GAACT------------TAAAGTA----AAATA--AA------AA- -------AAAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA6 -----------------------------CCGTTCCAAGATG--GCCGAAT-AGGAACAG CTCTGGTCTGC---AGCTCCCA--------GCGTGATCGACG------------------ ---------------------CAGA----------AGACGGGTGATTTC--------TGC AT--TTCCAACTG-A-----GGTACCTGGTTCATCTCATTGGGA-----------CTGGT TGGA---CAGTGGGT--GCA--------------G--------------CCCATGGAGGG C---------------------GAGCCGAAGCAGGGCGGGGCGTCG-------------- ------------CCTCACCCG-----------------GG--AAGT--GCAAGGGGTCG- -------------GGGG---ATTTCCCTTT----CCTAG-----CCA-----AG-GGAAG CCGTGACAGACTGTAC------CTGGAAAAACGGGACACTCCCG-CCCAAATACTGCGCT T-------------------------TTCCCATGG-TCTTAGCAACCGGC----AGACCA GGAGAT-TCTCTCCCGTG---CCT------------------------------------ ---G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GCTCGGTGG----- -----GTCCCACGC-CCACGGAGC-------CTTG------------------------- -------------------CTCACT-GCTAGC--------------G-----CAG----- ------------------------------------CAGTCTGAGAT------------- -------------------CGACCTGCGA-GGCTGCA--G-----CCTG----------- -GTGGGGGG------AGGGGC-------------------GTCCGCCATTGCTGAGG--- -----------------------------------------CTT--GAGTAG-------- -----------GTAAACAAAGCGGCCAGG--------------AAGCTCGAACTGG---- -------------------GTGGAGCCCACCGCAG----------------CTCAGCAA- -----------------------------------GGCC--------------------- -------TA-CTG---------------CCTCTATAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ACTCCACCTCTGTGG-----------------------GCA GG-GCATAGCT-------------------------------GAAC-AA----------- --------------------------------------AAGGCAGCA------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GAAAC-------------------- TTCT--------GCAGAC------------------------------------------ -TTAAACGT------CCCTGTC--TGACAGCTCTGAAGA--------------------- ---------G-A-----GCAGTG--------------GT----------------TCTCC CAG----------------------CATGGCGTTTGAGCTCTGAGAATGG--------A- ---C--------AGACTGC--------CTCCTCAA---------------------GTGG GT-------CC---CTGACCCCC-----GT-----GTAGCCTA---------------AC TGGGAGACAC--CTCCCA---------------GTAGGG------GCCG----------- -----------A-------------------------CAGACACCTCAT----------- -----ACAGGCG----------------------------GG------------------ ------TGCCCCTCTGGGACGAAGCT---------------------------------- ----------------------------------------------TCCA---------- -----------GAGGAAGGAT--CAGG----------------------------CAGCA ATATTTGCTGTTCTGCAATATTTG------------------CTGTTCTGCAGC--CTCC GCTGGTGAT----------ACC-------------------CAGGCAAACA--------- ------------G-GGTCTGGAG------------------------TGGACC---TCCA GCAAA-------------CTCCA---------ACAG------------------------ -------------------------------------------A--CCTGCAGCTGAG-- -----------GGACCTGACTGTTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAAGGAA------------------------------AAC T-----------AACAAACAGAAA------------------------------------ --------------------------------------------------G--------- ---------GAATAGCATCAACAT--------CAACAAAAAGGACATCCACAC------- ------------------------------------------------------------ -----------CAAAACCC----------------------CAT---------------- -----------CTGTAGGTCACC------------------------------------- --AACATCAA-AGACCAAA--------------G-------------------------- ---GTAGATAA------AACC--------------------------------------- ------------------------AC-------AAAGTGGGGAG---------------- ------AAACCAGA-------GCAGAAAAGCT-------GAAAATTCTAAAAACCAGAGC GCCTCTTCTCCTC-----CAA------------AGGATCGCAGCTCCTCG---------- CCAG---CAACGGAACAAA-------GCT-GGACGGAGAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-CTTTGACG AGTT------GACAGAAG------TAGGC------------TTCAGAAG---GTCGGT-A ATAACAA---ACTTCTCCGAGCT----AAAGGAGCATG---------------------- ------------------------------TTCTAACCCATCGC---AAGGAAGC----- ----------------------------------------T------------------- -------AAAAACCTTGAAAAAAGG---TTAGACGAATG--------------------- ----------------------GCTAA-------------CTAG------AATAAACAGT --------------------------------------GTAGAGAAGACC---------- -----TTAAATGACC--------------------------------------------- ------------------------TGAT-GGAGC---TGAAA---------ACCAT---- -GGCACGAGAA----CTTCGTGACGCATGCA-------CAAG------------------ --------------------------------------------CTTCAATAGCCGATT- -----CGATC--AAGT------------------GGAAG---------AAAG-GAT-ATC AGTGATT----------------------------------------------------- ------------------------------------------------------------ ----GAAGATCAAATTAATGAAA-T--AAAGCGA------GAAG---------ACAA--- ------------------GTTTAGAGAAAAA---AGA---GTAAAAAGAAA--------- TGA-ACAAAGCCTCCAA--GAAATATGGG-ACTATGTG-----------AAAAG--ACCA AATCTACGTT-TGATTGG--TGTACCTGAAA--------------GTGACGGGGAGAATG GAACCAAGTTGG---------AAAACACTCTTCA--G--------GATATTATCCA-G-G AGAACTTCCCCAACCT--------------------AGCAAGGCAGGCCA--ACATTCAA ATTC-----AGGAAATACAGAGAAC---ACCACA-AAGAT--------ACT--------- ---C-CTCGAGAA-----GAGCAACCCCAA----------------------------GA CACATAATTGTCAGATT------CAC-CAAGG---------TTGAAATGA---------- ------------AGG--AAAAAATGT---------------------------------- --------TAAGGGCAGCCAGAGA---GAAAGGTC--------------GGGTTAC---C CAC----------AAAG--------------GGAAGCCCAT--CAGACTAA-C--AGCGG ATC--------TCTCGGCAGAA--ACCCTA-CAAG--CCAG-AAGAGAGTG--------- ----GGG-GCCAATA-T-------TCAACA--T-TCT-TAAAGAAAAG------------ -AAT-TT--TCA--ACCCAGAA--------TTTCAT----------ATCCA--------- --GCCAAACTAAGC-----TTCA-TAAGTGA-------AGG-AGAAATAAAATCCTTTAC AGACAAGC-AAATGCTGAGAGA-TTTTGTCACCACCAGGC---CTGCCTTAC-AAGAGCT CCT--------------GAAGGA----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------CAACCGGTACCAGC CACTGC------AAAAACATGCC------A---------------AATT-----GGTAAA ----GA------CCATCGATGCT----ATGA-------AGAAACTGC-----ATCAATTA ACGGGCAAAATAACCAGCTAACATC-------------------------------A--- ------------------------------------------------TATGACA----- --------------------GGATCAA--ATTC-ACACATAACAATAT------------ -------------TAAC-CTTAAATG-TAAATGGGCT--AAATGC---CCCAATTAAAAG ACACAGAC--TGGCAAAT-TGGAT------------AAAGAGTCAAGACCCATCAG---- ---TGT-GCTGTATTCAGGAG-ACCCATCT-CACGT--GCAGAGACACACATAGGCTCAA AA--TAAAGGGA--TGGAGGA-AGATCTACCAAGCAAATGG------AAAGCAAAAAAAA AAAAAAAAAAAAAAAAAA-AAAGCAG--GGGTTGCAATCCTAGTCTC-TGATAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAGAGAC-AAAG-AAGGCCATTACAT-- ----AATGGTAAA---GGGATCAATTCAAC--AAGAAG--------AG-CTAACTATCCT AA-----------------ATATATATGCACCCAATACAGGAGCACCCAG--ATTCATAA AGCAAGTCCTTAGAGACCTACAAAGAGACTTAGACTCCCACAC---------AATAATAA TGGGAGACTTTAACACCCCAC-----TGTCAATATTAGACAGA----------------- ----TCAACGAGAC------AGAA-----GGTTAACAAGGATATCCAGGACTTG------ --AACTCAGCTCTGCACCAAGCGGAC-CTAATAG--ACATCTACAGAA--CTCTCCACCC CAAATCAA---CAGAATATACATTCTTCTCA-------GCACCACAT---CGCACTTATT C------CAAAATTGACCACATAGTTGGAAGTAAAGCACT-------------------- -CCTCAGCAAATGTAAAAGAA--CAGAAAT----------------CACAACAA------ -ACTGTCTCTCA---GACCACAGTGCAA-TCAAATTAGAACTCAGGATTA--------AG A-------------AA-CTCACTC---AAAACCGCACAA----CTACATGGAAACTGAAC AACCTG-CTCCTGAA---TG-ACTACTG--GGTAA---ATAACGAAAT--GAA-GGCAGA AATAAAGATGTTCTTT---GAAAC------------------------CAATGAGAACAA -AGACACAAC--GTACCAGAATCTC-TGG-GACACATTTAAAGCAGTGTGTAGAGGGAAA --TTTATAGCACTAAATGCCCACAAGAGAAAGC---AGGA--AAGATCT---AAAATCGA ------CACCCTAACATCACAATTAAA---AGAACTAGAGAA---GC---AAGAGCAAAC AAATTCAA-AAGCTAGCA------------GAAGGCAAGAAATAAC-TAAGATCAGAGCA GAACTG---AAGGAGATAGAGACACAAAAAA-CCC---TTCAAAAAATC-AATGAATCCA -GGAGC-------TGGTTTTTTGAAAAGATCAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGATAGACCG---CTAGCAA------GACT-------------- AATAAAGAAGAAAAG---A---GAGA-AGAATCAAATAGA-------------------- -----CGCAA---T---------AAAAAATGATAAA------GGGGA---TATCACCACC G--------ATCC-CACAGAAATA-CAAACTACC--ATCAG---------AGAAT----- -------------------ACTATAAACAC-CTCTACGCAAATAA--AC---TAGAAAAT CTAG---AAGAAAT--GGATAAATTCCT--G---GACACA---------TAC-----ACC CTCCCA------AGACTAAACCAGGAAGAAGTTGAATCTCTGAAT--------------- --------AGACCA------A------TAACAGGCTCTGAAAT----TGAGG--CAATAA -TTAATAGCCTACCAACCAAAAAAAG--TC-CAGGACC--AGACGGATTCACAGCCGAA- TTCTA------------CCAGAGGTAC----AAAGAGGAGCTGGTA-CCATTC-----C- ----TTCTGAAACTATTCCAA-------TCAATAG-AAAAAGAGGG-----------AAT CCTCCCTAACTCATTTTATGAG---------GCCAGCAT---CATCCTGATACC--AAAG C-----------------------CTGGC--AGAGACA-CAAC----AA---------AA AAAGAGAATT---------------------TTA------GACCAATAT--CCC----TG ATGAACATCGAT------------------------GCGAAAATCC-TCAA--------- ------TAAAATACTGGC-AAACCG------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGCTTATCCA--CCA ----CGAT------------CAAGTCGGC-TTCATCCCTGGGA-TGCAAG---------- -------------GCTGGTTC-AAC-----ATACGC----AAATCAATAAACGTA--ATC CATCAC---------A------TAAACAG----AACCAACGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAGG---CCTTCGACAA---AA TTCAACAGCCCTT-------------------CATGC---------T-AAAAAC-TCTCA --ATAAACTAGGTATTGATGGAACGT-----ATCTCAAAATAAT---------------- -----------AAGAGCTAT-TTAT-GACAAACCCACAGC-----------CAATAT--C ATACTGAATGGGCAAAA-A-----CTGGAAGC-ATTC---CCTTTGAAAA----CTGGCA CAAGACAGGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTGTT---GGAAG TTCTGGCCAG--------GGCAATCAG------GCAAGAG---AAAGA--AATAAAGGGT ATTCAATTAGGAAA-------AGAGGAAGTCAAA--TTGTCCCTG-----TTTGCAGATG AC--ATGATTGTA-------TATTTAGAAAACCCC---------------ATCGT---CT CAGCCC---------AAA--ATCTCCTTAAGCT---------GATAAG--CAACTTCAGC AAAG--TC-------------------------TCAGGATACAA--------------AA TCAATGT------------GCAAAAAT----CACAAGCATTCC--TA-TACACCAA--TA ACAGACAAACAGA------------------GAGCCAAA-TCATG----AGTGAACTCCC ATTCACAATTGC-TACAAA---GAGAATAAAATACCTAGGAATCCAACT--------TAC -AAGGGATGTGAAGGACCTCT---TCAAGGAG--AACTACAAACCACTGCTC-AACGAAA TAAAAGA-----------GG------------------ACAC--AAAC--AAATGGAAGA ACAT------T---CCATGCTCATG------GATAGGAAGAATC-----AATA-TCGTG- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----GGTAATTTATAGA---TTCAATGCCATCCCCATCAAGCT---------ACCAATG- AC------------TTTCTT---------------------------------------- --CACAGAATTGG---AAA------AAACTACTTTAAAG-TTCATATGGAA-------CC AAAAAAGAGCCC---GC--ATTGCCAAGACAATCCTAAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACG---CTACCTGACTTCAAACT-----ATACTACAA---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CCAA AACAGAGA------TATAGAC--CAATGGAACAGAACAGAGGCCTC------AG--AAAT AAC---ACCACACATCTACA----ACCATC--TGATCTTT---GACAAA--CCTGA--CA AAAACAAGA--AATGG-----GGAAAGG----ATTCC--------CTATT--TAATAAAT GGTGCTG----------G-GAAAAC--TGG-C-TAGCCA---------------TATGT- AGA---------AAG--CTGAAACTGGATCCCT----TCCT---------------TACA CC--TTATACAAAAA-TTAATT-CAAGATGGATTAAAGACTTAAATGTT--AGACCTAAA ACC-AT------------------------AAAAACCCTAGAA----------------- ------GAAA--ACCTA------G---------GCA---------ATACCATTCAGGAC- --ATA-----GG-CATGGGCAAGGACTTCATGACTAA-AACACCA-AAA----GCAATGG CAACAAAAGCCAA----A------AT---AGAC--AAA-TGGGATCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTACCATC-AGAG-TGAACAG-GCAAC CTAC--AGAA--T-GGGAG--AAAATTTTT---GCAATCTACCCAT--------CTGACA AAGGGCTAA-------TATCCAGAATCTACA--AAGAA--CTTAA-----ACAAA----- ----------------------TTTACAAGAA------AAAAAC------------A--- AACAACCCCA-TCAAAA----------AGTGGGCAAA-----------GGA--TATGAAC ---AGACACTTCTCAAAAGAAGACATTTATG--------------CAGCCAAC-AGACAC ATGAAAAAATG----CTCATCATCACTGG-TCATCAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACACCAGTTAGAATGGCGA-- ----TCATTAAAA---AGTCAGGAA-----------ACAACAG--ATG--CTGGA-G--- ---------------AGGATGTGGAGAA-------------------------------- -----ATAGGAACGCTTTT-ACACTGTTGG--TGGGAG---------------------- -------------TGTA-------------AACTA-GTTCAACC--------ATTGTGG- -------AAGACA-GTGTGGCG--ATTC-CTCAAGGATCTAGAA--CTAGAAATACCA-- -TTTGA--CCCAGCCATCCCATTACTGGG-TATATA-CCCAAAGG-ATT--ATAA----- -------------------ATCATGCT-ACTAT--AAAGACACATG----------C--- ---------ACACG--TATGTTTATTGCGGCACTATT---CACAATA-GCAAAGACTT-G GA--ACCA--ACCCAAA-TGTCCATCA---ATGATAG-----ACTGGATTAA--GAAAA- TG---------------------------------------------------------- --------------------TGGCACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AAGGATGAGTTCATGTCCTTT----------- ------------------------------------------------------------ -GCAGGGACATGGATGAAG-C---T----------------GGAAACCATCATTCTGAGC AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------TCACA--AGGAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAA---- -----------------------------CCAAACAC-CGCATG--------TTC----- ------TCACT---CAT------------------------AGGTGGGAAT---TTGAAC A-------A--------------TGAGAA---------------C--------------- ------------------------------------ACTTG-------------GACA-- -------CA------------------------------------------GGGCGG--- -GGAACATCACA---CACCG-----GGGCCTGTC---------GGGGGG----------- TGG-GGGGCTGG------------------------------------------------ --GGG-------AGGGAT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGC----------ATTAG-GAGAAATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CCTAATG---------------------------------------------- ----------------------------------------------------TAAAT--G ACGAGT--------------------------------------TGATGGGT-------G CAG-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCAACATG-- -------------------GCACA-TGTATA--------C-------------CTATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA-----AACCTGCAC----------------------------------------- ------GTTG-TGCACA-------------------------------TGTACC------ ------------------------------------------------------------ -------------------------------------------------CTA-------- --------------GAACT------------TAAAGTA----TAATAAAAA------AA- -------AAAAA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA3 -------------------------GGGGGGCAGCCAAGATG--GCCGAAT-AGGAACAG CTCCGGTCTAC---AGCTCCCA--------GCGTGAGCGACG------------------ ---------------------CAGA----------AGACGGGTGATTTC--------TGC AT--TTCCATCTG-A-----GGTACCGGGTTCATCTCACTAGGG-----------AGTGC CAGA---CAGTGGGC--GCAGGACAGTGGGTGCAG--------------CGCACCGTGCG C---------------------GAGCCGAAGCAGGGCGAGGCATTG-------------- ------------CCTCACTCG-----------------GG--AAGC--GCAAGGGGTCA- -------------GGGA---G-TTCCCTTT----CCTAG-----TCA-----AA-GAAAG GGGTGACAGACGGCAC------CTGGAAAATCGGGTCACTCCCA-CCCTAATACTGCGCT T-------------------------TTCCGACGG-GCTTAAAAAACGGC----GCACCA GGAGAT-TATATCCCGCA---CCT------------------------------------ ---G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GCTCGGAGG----- -----GTCCTACGC-CCACGGAGT-------CTCG------------------------- -------------------CTGATT-GCTAGC--------------A-----CAG----- ------------------------------------CAGTCTGAGAT------------- -------------------CAAACTGCAA-GGCGGCA--G-----CGAG----------- -GCTGGGGG------AGGGGC-------------------GCCCGCCATTGCCCAGG--- -----------------------------------------CTT--GCTTAG-------- -----------GTAAACAAAGCAGCCGGG--------------AAGCTCGAACTGG---- -------------------GTGGAGCCCACCACAG----------------CTCAAGGA- -----------------------------------GGCC--------------------- -------TGCCTG---------------CCTCTGTAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GCTCCACCTCTGGGG-----------------------GCA GG-GCACAGAC-------------------------------AAACAAA----------- --------------------------------------AAGACAGCA------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GTAAC-------------------- CTCT--------GCAGAC------------------------------------------ -TTAAATGT------CCCTGTC--TGACAGCTTTGAAGA--------------------- ---------G-A-----GCAGTG--------------GT----------------TCTCC CAG----------------------CACGCAGCTGGAGATCTGAGAACGG--------G- ---C--------AGACTGC--------CTCCTCAA---------------------GTGG GTCCCTGACCC---CTGACCCCC-----GA-----GCAGCCTA---------------AC TGGGAGGCAC--CCCCCA---------------GTAGGG------GCAG----------- -----------A-------------------------CTGACACCTCAC----------- -----ACGGCCG----------------------------GG------------------ ------TACTCCTCTGAGACAAAACT---------------------------------- ----------------------------------------------TCCA---------- -----------GAGGAACGAT--CAGA----------------------------CAGCA GCATTCGCGGTTCACGAAAATCCG------------------CTGTTCTGCAGC--CACC GCTGCTGAT----------ACC-------------------CAGGCAAACA--------- ------------G-GGTCTGGAG------------------------TGGACC---TCTA GCAAA-------------CTCCA---------ACAG------------------------ -------------------------------------------A--CCTGCAGCTGAG-- -----------GGTCCTGTCTGTTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAAGGAA------------------------------AAC T-----------AACAAACAG--------------------------------------- ------------------------------------------------------------ --------------------------------------AAAGGACATCCACAC------- ------------------------------------------------------------ -----------CAAAAACC----------------------CAT---------------- -----------CTGTACATCACC------------------------------------- --ATCATCAA-AGACCAAA--------------A-------------------------- ---GTAGATAA------AACC--------------------------------------- ------------------------AC-------AAAG-AGGGAA---------------- ------AAAACAGA-------GCAG-AAAACT-------GGAAACTCTAAAAAGCAGAGC GCCTCTCCTCCTC-----CAA------------AGGAACGCAGTTCCTCA---------- CCAG---CAATGGAACAAA-------GCT-GGACGGAGAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-CTTTGACG AGCT------GAGAGAAG------AAGGCACATATCTCAAATTCAGACG---AT------ ----CAA---ACTACTCTGAGCT----ACAGGAGGAAA---------------------- ------------------------------TTCAAACCAAAGGC---AAAGAAGT----- ----------------------------------------T------------------- -------AAAAACTTTGAAAAAAAA---TTAGACGAATG--------------------- ----------------------GATAA-------------CTAG------AATAACCAAT --------------------------------------GCAGAGAAGGGCTACCCTCTCT CACCATTAAAGGAGC--------------------------------------------- ------------------------TGAT-GGAGC---TGAAA---------GCCAA---- -GGCTCGAGAA----CTACGTGAAGAATGCA-------GAAG------------------ --------------------------------------------CCTCAGTAGCCGATG- -----CGATC--AACT------------------GGAAG---------AAAG-GGT-ATC AGCGATA----------------------------------------------------- ------------------------------------------------------------ ----GAAGATGAAATGAATGAAA-T--GAAGCGA------GAAG---------GGAA--- ------------------GTTTAGAGAAAAA---AGA---ATAAAAAGAAA--------- TGA-ACAAAGCCTCCAA--GAAATATGGG-ACTATGTG-----------AAAAG--ACCA AATCTACGTC-TGATTGG--TGTACCTGAAA--------------GTGACGGGGAGAATG GAACCAAGTTGG---------AAAACACTCTGCA--G--------GATATTATCCA-G-G AGAACTTCCCCAATCT--------------------AGCAAGGCAGGCCA--ACATTCAG ATTC-----AGGAAATACAGAGAAC---GCCACA-AAGAT--------ACT--------- ---C-CTCGAGAA-----GAGCAACTCCAA----------------------------GA CACATAATTGTCAGATT------CAC-CAAAG---------TTGAAATGA---------- ------------AGG--AAAAAATGT---------------------------------- --------TAAGGGCAGCCAGAGA---GAAAGGTC--------------AGGTTAC---C CAC----------AAAG--------------GGAAGCCCAT--CAGACTAA-C--AGCAG ATC--------TCTCGGCAGAA--ACTCTA-CAAG--CCAG-AAGAGAGTG--------- ----GGG-GCCAATA-T-------TCAACA--T-TCT-TAAAGAAAAG------------ -AAT-TT--TCA--ACCCAGAA--------TTTCAT----------ATCCA--------- --GCCAAACTAAGC-----TTCA-TAAGTGA-------AGG-AGAAATAAAATACTTTAC AGACAAGC-AAATGCTGAGAGA-TTTTGTCACCACCAGGC---CTGCCCTAA-AAGAGCT CCT--------------GAAGGA----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------CAACCGGTACCAGC CACTGC------AAAAACATGCC------A---------------AAAT-----GGTAAA ----GA------CCATCGAGGCT----AGGA-------AGAAACTGC-----ATCAACTA ACGAGCAAAATAACCAGCTAACATC-------------------------------A--- ------------------------------------------------TATGACA----- --------------------GGATCAA--ATTC-ACACATAACAATAT------------ -------------TAAC-TTTAAATG-TAAATGGACT--AAATGC---TCCAATTAAAAG ACACAGAC--TGGCAAAT-TGGAT------------AAAGAGTCAAGACCCATCAG---- ---TGT-GCTGTATTCAGGAA-ACCCATCT-CACGT--GCAGAGACACACATAGGCTCAA AA--TAAAAGGA--TGGAGGA-AGATCTACCAAGCAAATGG------AAAAC-------- -------------AAAAA-AAGGCAG--GGGTTGCAATCCTAGTCTC-TGATAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAGAGAC-AAAG-AAGGCCATTACAT-- ----AATGGTAAA---GGGATCAATTCAAC--AAGAAG--------AG-CTAACTATCCT AA-----------------ATATATATGCACCCAATACAGGAGCACCCAG--ATTCATAA AGCAAGTCCTGAGTGACCTACAAAGAGACTTAGACTCCCACAC---------AATAATAA TGGGAGACTTTAACACCCCAC-----TGTCAACATTAGACAGA----------------- ----TCAACGAGAC------AGAA-----AGTTAACAAGGATACCCAGGAATTG------ --AACTCAGCTCTGCACCAAGCGGAC-CTAATAG--ACATCTACAGAA--CTCTCCACCC CAAATCAA---CAGAATATACATTTTTTTCA-------GCACCACAC---CACACCTATT C------CAAAATTGACCACATAGTTGGAAGTAAAGCTCT-------------------- -CCTCAGCAAATGTAAAAGAA--CAGAAAT----------------TATAACAA------ -ACTGTCTCTCA---GACCACAGTGCAA-TCAAACTAGAACTCAGGATTA--------AG A-------------AA-CTCACTC---AAAACCGCTCAA----CTACATGGAAACTGAAC AACCTG-CTCCTGAA---TG-ACTACTG--GGTAC---ATAACGAAAT--GAA-GGCAGA AATAAAGATGTTCTTT---GAAAC------------------------CAACGAGAACAA -AGACACAAC--ATACCAGAATCTC-TGG-GACACATTCAAAGCAGTGTGTAGAGGGAAA --TTTATAGCACTAAATGCCCACAAGAGAAAGC---AGGA--AAGATCC---AAAATTGA ------CACCCTAACATCACAATTAAA---AGAACTAGAAAA---GC---AAGAGCAAAC ACATTCAA-AAGCTAGCA------------GAAGGCAAGAAATAAC-TAAAATCAGAGCA GAACTG---AAGGAAATAGAGACACAAAAAA-CCC---TTCAAAAAATT-AATGAATCCA -GGAGC-------TGGTTTTTTGAAAGGATCAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGATAGACCG---CTAGCAA------GACT-------------- AATAAAGAAGAAAAG---A---GAGA-AGAATCAAATAGA-------------------- -----CGCAA---T---------AAAAAATGATAAA------GGGGA---TATCACCACC G--------ATCC-CACAGAAATA-CAAACTACC--ATCAG---------AGAAT----- -------------------ACTACAAACAC-CTCTACGCAAATAA--AC---TAGAAAAT CTAG---AAGAAAT--GGATAAATTCCT--C---GACACA---------TAC-----ACC CTCCCA------AGACTAAACCAGGAAGAAGTTGAATCTCTGAAT--------------- --------AGACCA------A------TAACAGGCTCTGAAAT----TGTGG--CAATAA -TCAATAGCTTACCAACCAAAAAGAG--TC-CAGGACC--AGATGGATTCACAGCCGAA- TTCTA------------CCAGAGGTAC----AAGGAGGAACTGGTA-CCATTC-----C- ----TTCTGAAACTATTCCAA-------TCAATAG-AAAAAGAGGG-----------AAT CCTCCCTAACTCATTTTATGAG---------GCCAGCAT---CATCCTGATACC--AAAG C-----------------------CGGGC--AGAGACA-CAAC----CA---------AA AAAGAGAATT---------------------TTA------GACCAATAT--CCT----TG ATGAACATTGAT------------------------GCAAAAATCC-TCAA--------- ------TAAAATACTGGC-AAACCG------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGCTTATCCA--CCA ----TGAT------------CAAGTGGGC-TTCATCCCTGGGA-TGCAAG---------- -------------GCTGGTTC-AAT-----ATACGC----AAATCAATAAATGTA--ATC CAGCAT---------A------TAAACAG----AACCAAAGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAGG---CCTTTGACAA---AA TTCAACAACCCTT-------------------CATGC---------T-AAAAAC-TCTCA --ATAAATTAGGTATTGATGGGACGT-----ATCTCAAAATAAT---------------- -----------AAGAGCTAT-CTAT-GACAAACCCACAGC-----------CAATAT--C ATACTGAATGGGCAAAA-A-----CTGGAAGC-ATTC---CCTTTGAAAA----CTGGCA CAAGACAGGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTGTT---GGAAG TTCTGGCCAG--------GGCAATTAG------GCAGGAG---AAGGA--AATAAAGGGT ATTCAATTAGGAAA-------AGAGGAAGTCAAA--TTGTCCCTG-----TTTGCAGATG AC--ATGATTGTA-------TATCTAGAAAACCCC---------------ATTGT---CT CAGCCC---------AAA--ATCTCCTTAAGCT---------GATAAG--CAACTTCAGC AAAG--TC-------------------------TCAGGATACAA--------------AA TCAATGT------------ACAAAAAT----CACAAGCATTCT--TA-TACACCAA--TA ACAGACAAACAGA------------------GAGCCAAA-TCATG----AGTGAACTCCC ATTCACAATTGC-TTCAAA---GAGAATAAAATACCTAGGAATCCAACT--------TAC -AAGGGACGTGAAGGACCTCT---TCAAGGAG--AACTACAAACCACTGCTC-AATGAAA TAAAAGA-----------GG------------------ATAC--AAAC--AAATGGAAGA ACAT------T---CCATGCTCATG------GGTAGGAAGAATC-----AATA-TCGTG- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----GGTAATTTATAGA---TTCAATGCCATCCCCATCAAGCT---------ACCAATG- AC------------TTTCTT---------------------------------------- --CACAGAATTGG---AAA------AAACTACTTTAAAG-TTCATATGGAA-------CC AAAAAAGAGCCC---GC--ATCGCCAAGTCAATCCTAAGCCAAAAGAACA---AAGC--T -------GGAGGCATCACG---CTACCTGACTTCAAACT-----ATACTACAA---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CCAA AACAGAGA------TATAGAT--CAATGGAACAGAACAGAGCCCTC------AG--AAAT AAC---GCCGCATATCTACA----ACTATC--TGATCTTT---GACAAA--CCTGA--GA AAAACAAGC--AATGG-----GGAAAGG----ATTCC--------CTATT--TAATAAAT GGTGCTG----------G-GAAAAC--TGG-C-TAGCCA---------------TATGT- AGA---------AAG--CTGAAACTGGATCCCT----TCCT---------------TACA CC--TTATACAAAAA-TTAATT-CAAGATGGATTAAAGACTTAAACGTT--AGACCTAAA ACC-AT------------------------AAAAACCCTAGAA----------------- ------GAAA--ACCTA------G---------GCA---------ATACCATTCAGGAC- --ATA-----GG-CATGGGCAAGGACTTCATGTCTAA-AACACCA-AAA----GCAATGG CAACAAAAGCCAA----A------AT---TGAC--AAA-TGGGATCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTACCATC-AGAG-TGAACAG-GCAAC CTAC--AAAA--T-GGGAG--AAAATTTTC---GCAACCTACTCAT--------CTGACA AAGGGCTAA-------TATCCAGAATCTACA--ATGAA--CTCAA-----ACAAA----- ----------------------TTTACAAGAA------AAAAAC------------A--- AACAACCCCA-TCAAAA----------AGTGGGCGAA-----------GGA--CATGAAC ---AGACACTTCTCAAAAGAAGACATTTATG--------------CAGCCAAA-AAACAC ATGAAAAAATG----CTCACCATCACTGG-CCATCAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACACCAGTTAGAATGGCGA-- ----TCATTAAAA---AGTCAGGAA-----------ACAACAG--GTG--CTGGA-G--- ---------------AGGATGTGGAGAA-------------------------------- -----ATAGGAACACTTTT-ACACTGTTGG--TGGGAC---------------------- -------------TGTA-------------AACTA-GTTCAACC--------ATTGTGG- -------AAGTCA-GTGTGGCG--ATTC-CTCAGGGATCTAGAA--CTAGAAATACCA-- -TTTGA--CCCAGCCATCCCATTACTGGG-TATATA-CCCAAAGG-ACT--ATAA----- -------------------ATCATGCT-GCTAT--AAAGACACATG----------C--- ---------ACACG--TATGTTTATTGCGGCACTATT---CACAATA-GCAAAGACTT-G GA--ACCA--ACCCAAA-TGTCCAACA---ATGATAG-----ACTGGATTAA--GAAAA- TG---------------------------------------------------------- --------------------TGGCACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AATGATGAGTTCATGTCCTTT----------- ------------------------------------------------------------ -GTAGGGACATGGATGAAA-C---T----------------GGAAATCATCATTCTCAGT AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------TCGCA--AGGAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAAA---- -----------------------------CCAAACAC-CGCATG--------TTC----- ------TCACT---CAT------------------------AGGTGGGAAT---TTGAAC A-------A--------------TGAGAA---------------C--------------- ------------------------------------ACATG-------------GACA-- -------CA------------------------------------------GGAAGG--- -GGAACATCACA---CTCTG-----GGGACTGTT---------GTGGGG----------- TGG-GGGGAGGG------------------------------------------------ --GGG-------AGGGAT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGC----------ATTAG-GAGATATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CCTAATG---------------------------------------------- ---------------------------------------------------CTAAAT--G ACGAGT--------------------------------------TAATGGGT-------G CAG-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CACCAGCATG-- -------------------GCACA-TGTATA--------C-------------ATATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACT-----AACCTGCAC----------------------------------------- ------ATTG-TGCACA-------------------------------TGTACC------ ------------------------------------------------------------ -------------------------------------------------CTA-------- --------------AAACT------------TAAAGTA----TAATAATAA------TA- -------AAATA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1HS -------------------------GGGGAGGAGCCAAGATG--GCCGAAT-AGGAACAG CTCCGGTCTAC---AGCTCCCA--------GCGTGAGCGACG------------------ ---------------------CAGA----------AGACGGGTGATTTC--------TGC AT--TTCCATCTG-A-----GGTACCGGGTTCATCTCACTAGGG-----------AGTGC CAGA---CAGTGGGC--GCAGGCCAGTGTGTGT-G--------------CGCACCGTGCG C---------------------GAGCCGAAGCAGGGCGAGGCATTG-------------- ------------CCTCACCTG-----------------GG--AAGC--GCAAGGGGTCA- -------------GGGA---G-TTCCCTTT----CCGAG-----TCA-----AA-GAAAG GGGTGACGGAC-GCAC------CTGGAAAATCGGGTCACTCCCA-CCCGAATATTGCGCT T-------------------------TTCAGACCG-GCTTAAGAAACGGC----GCACCA CGAGAC-TATATCCCACA---CCT------------------------------------ ---G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GCTCAGAGG----- -----GTCCTACGC-CCACGGAAT-------CTCG------------------------- -------------------CTGATT-GCTAGC--------------A-----CAG----- ------------------------------------CAGTCTGAGAT------------- -------------------CAAACTGCAA-GGCGGCA--A-----CGAG----------- -GCTGGGGG------AGGGGC-------------------GCCCGCCATTGCCCAGG--- -----------------------------------------CTT--GCTTAG-------- -----------GTAAACAAAGCAGCCGGG--------------AAGCTCGAACTGG---- -------------------GTGGAGCCCACCACAG----------------CTCAAGGA- -----------------------------------GGCC--------------------- -------TGCCTG---------------CCTCTGTAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GCTCCACCTCTGGGG-----------------------GCA GG-GCACAGAC-------------------------------AAACAAA----------- --------------------------------------AAGACAGCA------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GTAAC-------------------- CTCT--------GCAGAC------------------------------------------ -TTAAGTGT------CCCTGTC--TGACAGCTTTGAAGA--------------------- ---------G-A-----GCAGTG--------------GT----------------TCTCC CAG----------------------CACGCAGCTGGAGATCTGAGAACGG--------G- ---C--------AGACTGC--------CTCCTCAA---------------------GTGG GTCCCTGACCC---CTGACCCCC-----GA-----GCAGCCTA---------------AC TGGGAGGCAC--CCCCCA---------------GCAGGG------GCAC----------- -----------A-------------------------CTGACACCTCAC----------- -----ACGGCAG----------------------------GG------------------ ------T----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----A-------------TTCCA---------ACAG------------------------ -------------------------------------------A--CCTGCAGCTGAG-- -----------GGTCCTGTCTGTTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAAGGAA------------------------------AAC T-----------AACAACCAG--------------------------------------- ------------------------------------------------------------ --------------------------------------AAAGGACATCTACAC------- ------------------------------------------------------------ -----------CGAAAACC----------------------CAT---------------- -----------CTGTACATCACC------------------------------------- --ATCATCAA-AGACCAAA--------------A-------------------------- ---GTAGATAA------AACC--------------------------------------- ------------------------AC-------AAAGTGGGGAA---------------- ------AAAACAGA-------ACAGAAAAACT-------GGAAACTCTAAAACGCAGAGC GCCTCTCCTCCTC-----CAA------------AGGAACGCAGTTCCTCA---------- CCAG---CAACAGAACAAA-------GCT-GGATGGAGAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-TTTTGACG AGCT------GAGAGAAG------AAGGC------------TTCAGACG---AT------ ----CAA---ATTACTCTGAGCT----ACGGGAGGACA---------------------- ------------------------------TTCAAACCAAAGGC---AAAGAAGT----- ----------------------------------------T------------------- -------GAAAACTTTGAAAAAAAT---TTAGAAGAATG--------------------- ----------------------TATAA-------------CTAG------AATAACCAAT --------------------------------------ACAGAGAAGTGC---------- -----TTAAAGGAGC--------------------------------------------- ------------------------TGAT-GGAGC---TGAAA---------ACCAA---- -GGCTCGAGAA----CTACGTGAAGAATGCA-------GAAG------------------ --------------------------------------------CCTCAGGAGCCGATG- -----CGATC--AACT------------------GGAAG---------AAAG-GGT-ATC AGCAATG----------------------------------------------------- ------------------------------------------------------------ ----GAAGATGAAATGAATGAAA-T--GAAGCGA------GAAG---------GGAA--- ------------------GTTTAGAGAAAAA---AGA---ATAAAAAGAAA--------- TGA-GCAAAGCCTCCAA--GAAATATGGG-ACTATGTG-----------AAAAG--ACCA AATCTACGTC-TGATTGG--TGTACCTGAAA--------------GTGATGTGGAGAATG GAACCAAGTTGG---------AAAACACTCTGCA--G--------GATATTATCCA-G-G AGAACTTCCCCAATCT--------------------AGCAAGGCAGGCCA--ACGTTCAG ATTC-----AGGAAATACAGAGAAC---GCCACA-AAGAT--------ACT--------- ---C-CTCGAGAA-----GAGCAACTCCAA----------------------------GA CACATAATTGTCAGATT------CAC-CAAAG---------TTGAAATGA---------- ------------AGG--AAAAAATGT---------------------------------- --------TAAGGGCAGCCAGAGA---GAAAGGTC--------------GGGTTAC---C CTC----------AAAG--------------GAAAGCCCAT--CAGACTAA-C--AGCGG ATC--------TCTCGGCAGAA--ACCCTA-CAAG--CCAG-AAGAGAGTG--------- ----GGG-GCCAATA-T-------TCAACA--T-TCT-TAAAGAAAAG------------ -AAT-TT--TCA--ACCCAGAA--------TTTCAT----------ATCCA--------- --GCCAAACTAAGC-----TTCA-TAAGTGA-------AGG-AGAAATAAAATACTTTAT AGACAAGC-AAATGTTGAGAGA-TTTTGTCACCACCAGGC---CTGCCCTAA-AAGAGCT CCT--------------GAAGGA----------------------AGCGC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------CAACCGGTACCAGC CGCTGC------AAAATCATGCC------A---------------AAAT-----GGTAAA ----GA------CCATCGAGACT----AGGA-------AGAAACTGC-----ATCAACTA ATGAGCAAAATCACCAGCTAACATC-------------------------------A--- ------------------------------------------------TATGACA----- --------------------GGATCAA--ATTC-ACACATAACAATAT------------ -------------TAAC-TTTAAATA-TAAATGGACT--AAATTC---TGCAATTAAAAG ACACAGAC--TGGCAAGT-TGGAT------------AAAGAGTCAAGACCCATCAG---- ---TGT-GCTGTATTCAGGAA-ACCCATCT-CACGT--GCAGAGACACACATAGGCTCAA AA--TAAAAGGA--TGGAGGA-AGATCTACCAAGCCAATGG------AAAAC-------- -------------AAAAA-AAGGCAG--GGGTTGCAATCCTAGTCTC-TGATAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAGAGAC-AAAG-AAGGCCATTACAT-- ----AATGGTAAA---GGGATCAATTCAAC--AAGAGG--------AG-CTAACTATCCT AA-----------------ATATTTATGCACCCAATACAGGAGCACCCAG--ATTCATAA AGCAAGTCCTGAGTGACCTACAAAGAGACTTAGACTCCCACAC---------ATTAATAA TGGGAGACTTTAACACCCCAC-----TGTCAACATTAGACAGA----------------- ----TCAACGAGAC------AGAA-----AGTCAACAAGGATACCCAGGAATTG------ --AACTCAGCTCTGCACCAAGCAGAC-CTAATAG--ACATCTACAGAA--CTCTCCACCC CAAATCAA---CAGAATATACATTTTTTTCA-------GCACCACAC---CACACCTATT C------CAAAATTGACCACATAGTTGGAAGTAAAGCTCT-------------------- -CCTCAGCAAATGTAAAAGAA--CAGAAAT----------------TATAACAA------ -ACTATCTCTCA---GACCACAGTGCAA-TCAAACTAGAACTCAGGATTA--------AG A-------------AT-CTCACTC---AAAGCCGCTCAA----CTACATGGAAACTGAAC AACCTG-CTCCTGAA---TG-ACTACTG--GGTAC---ATAACGAAAT--GAA-GGCAGA AATAAAGATGTTCTTT---GAAAC------------------------CAACGAGAACAA -AGACACCAC--ATACCAGAATCTC-TGG-GACGCATTCAAAGCAGTGTGTAGAGGGAAA --TTTATAGCACTAAATGCCTACAAGAGAAAGC---AGGA--AAGATCC---AAAATTGA ------CACCCTAACATCACAATTAAA---AGAACTAGAAAA---GC---AAGAGCAAAC ACATTCAA-AAGCTAGCA------------GAAGGCAAGAAATAAC-TAAAATCAGAGCA GAACTG---AAGGAAATAGAGACACAAAAAA-CCC---TTCAAAAAATC-AATGAATCCA -GGAGC-------TGGTTTTTTGAAAGGATCAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGATAGACCG---CTAGCAA------GACT-------------- AATAAAGAAAAAAAG---A---GAGA-AGAATCAAATAGA-------------------- -----CACAA---T---------AAAAAATGATAAA------GGGGA---TATCACCACC G--------ATCC-CACAGAAATA-CAAACTACC--ATCAG---------AGAAT----- -------------------ACTACAAACAC-CTCTACGCAAATAA--AC---TAGAAAAT CTAG---AAGAAAT--GGATACATTCCT--C---GACACA---------TAC-----ACT CTCCCA------AGACTAAACCAGGAAGAAGTTGAATCTCTGAAT--------------- --------AGACCA------A------TAACAGGCTCTGAAAT----TGTGG--CAATAA -TCAATAGTTTACCAACCAAAAAGAG--TC-CAGGACC--AGATGGATTCACAGCCGAA- TTCTA------------CCAGAGGTAC----AAGGAGGAACTGGTA-CCATTC-----C- ----TTCTGAAACTATTCCAA-------TCAATAG-AAAAAGAGGG-----------AAT CCTCCCTAACTCATTTTATGAG---------GCCAGCAT---CATTCTGATACC--AAAG C-----------------------CGGGC--AGAGACA-CAAC----CA---------AA AAAGAGAATT---------------------TTA------GACCAATAT--CCT----TG ATGAACATTGAT------------------------GCAAAAATCC-TCAA--------- ------TAAAATACTGGC-AAACCG------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGCTTATCCA--CCA ----TGAT------------CAAGTGGGC-TTCATCCCTGGGA-TGCAAG---------- -------------GCTGGTTC-AAT-----ATACGC----AAATCAATAAATGTA--ATC CAGCAT---------A------TAAACAG----AGCCAAAGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAAG---CCTTTGACAA---AA TTCAACAACCCTT-------------------CATGC---------T-AAAAAC-TCTCA --ATAAATTAGGTATTGATGGGACGT-----ATTTCAAAATAAT---------------- -----------AAGAGCTAT-CTAT-GACAAACCCACAGC-----------CAATAT--C ATACTGAATGGGCAAAA-A-----CTGGAAGC-ATTC---CCTTTGAAAA----CTGGCA CAAGACAGGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCGCTCCTATTCAA-CATA--GTGTT---GGAAG TTCTGGCCAG--------GGCAATCAG------GCAGGAG---AAGGA--AATAAAGGGT ATTCAATTAGGAAA-------AGAGGAAGTCAAA--TTGTCCCTG-----TTTGCAGACG AC--ATGATTGTT-------TATCTAGAAAACCCC---------------ATCGT---CT CAGCCC---------AAA--ATCTCCTTAAGCT---------GATAAG--CAACTTCAGC AAAG--TC-------------------------TCAGGATACAA--------------AA TCAATGT------------ACAAAAAT----CACAAGCATTCT--TA-TACACCAA--CA ACAGACAAACAGA------------------GAGCCAAA-TCATG----AGTGAACTCCC ATTCACAATTGC-TTCAAA---GAGAATAAAATACCTAGGAATCCAACT--------TAC -AAGGGATGTGAAGGACCTCT---TCAAGGAG--AACTACAAACCACTGCTC-AAGGAAA TAAAAGA-----------GG------------------ACAC--AAAC--AAATGGAAGA ACAT------T---CCATGCTCATG------GGTAGGAAGAATC-----AATA-TCGTG- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----GGTAATTTACAGA---TTCAATGCCATCCCCATCAAGCT---------ACCAATG- AC------------TTTCTT---------------------------------------- --CACAGAATTGG---AAA------AAACTACTTTAAAG-TTCATATGGAA-------CC AAAAAAGAGCCC---GC--ATCGCCAAGTCAATCCTAAGCCAAAAGAACA---AAGC--T -------GGAGGCATCACA---CTACCTGACTTCAAACT-----ATACTACAA---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CCAA AACAGAGA------TATAGAT--CAATGGAACAGAACAGAGCCCTC------AG--AAAT AAT---GCCGCATATCTACA----ACTATC--TGATCTTT---GACAAA--CCTGA--GA AAAACAAGC--AATGG-----GGAAAGG----ATTCC--------CTATT--TAATAAAT GGTGCTG----------G-GAAAAC--TGG-C-TAGCCA---------------TATGT- AGA---------AAG--CTGAAACTGGATCCCT----TCCT---------------TACA CC--TTATACAAAAA-TCAATT-CAAGATGGATTAAAGATTTAAACGTT--AGACCTAAA ACC-AT------------------------AAAAACCCTAGAA----------------- ------GAAA--ACCTA------G---------GCA---------TTACCATTCAGGAC- --ATA-----GG-CGTGGGCAAGGACTTCATGTCCAA-AACACCA-AAA----GCAATGG CAACAAAAGCCAA----A------AT---TGAC--AAA-TGGGATCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTACCATC-AGAG-TGAACAG-GCAAC CTAC--AACA--T-GGGAG--AAAATTTTC---GCAACCTACTCAT--------CTGACA AAGGGCTAA-------TATCCAGAATCTACA--ATGAA--CTCAA-----ACAAA----- ----------------------TTTACAAGAA------AAAAAC------------A--- AACAACCCCA-TCAAAA----------AGTGGGCGAA-----------GGA--CATGAAC ---AGACACTTCTCAAAAGAAGACATTTATG--------------CAGCCAAA-AAACAC ATGAAGAAATG----CTCATCATCACTGG-CCATCAGAGA-AAT--GCAAATC-AAAACC ACTATGAGA---------------------TATCATCTCACACCAGTTAGAATGGCAA-- ----TCATTAAAA---AGTCAGGAA-----------ACAACAG--GTG--CTGGA-G--- ---------------AGGATGTGGAGAA-------------------------------- -----ATAGGAACACTTTT-ACACTGTTGG--TGGGAC---------------------- -------------TGTA-------------AACTA-GTTCAACC--------ATTGTGG- -------AAGTCA-GTGTGGCG--ATTC-CTCAGGGATCTAGAA--CTAGAAATACCA-- -TTTGA--CCCAGCCATCCCATTACTGGG-TATATA-CCCAAAGG-ACT--ATAA----- -------------------ATCATGCT-GCTAT--AAAGACACATG----------C--- ---------ACACG--TATGTTTATTGCGGCACTATT---CACAATA-GCAAAGACTT-G GA--ACCA--ACCCAAA-TGTCCAACA---ATGATAG-----ACTGGATTAA--GAAAA- TG---------------------------------------------------------- --------------------TGGCACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AATGATGAGTTCATGTCCTTT----------- ------------------------------------------------------------ -GTAGGGACATGGATGAAA-T---T----------------GGAAACCATCATTCTCAGT AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------TCGCA--AGAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAAA---- -----------------------------CCAAACAC-CGCATA--------TTC----- ------TCACT---CAT------------------------AGGTGGGAAT---TTGAAC A-------A--------------TGAGAT---------------C--------------- ------------------------------------ACATG-------------GACA-- -------CA------------------------------------------GGAAGG--- -GGAATATCACA---CTCTG-----GGGACTGTG---------GTGGGG----------- TCG-GGGGAGGG------------------------------------------------ --GGG-------AGGGAT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGC----------ATTGG-GAGATATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CCTAATG---------------------------------------------- ---------------------------------------------------CTAGAT--G ACACGT--------------------------------------TAGTGGGT-------G CAG-----------------------------------------------------CG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CACCAGCATG-- -------------------GCACA-TGTATA--------C-------------ATATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACT-----AACCTGCAC----------------------------------------- ------AATG-TGCACA-------------------------------TGTACC------ ------------------------------------------------------------ -------------------------------------------------CTA-------- --------------AAACT------------TAGAGTA----TAATAAAAA------AA- -------AAAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA2 -------------------------GGGGAGGAGCCAAGATG--GCCGAAT-AGGAACAG CTCCGGTCTAC---AGCTCCCA--------GCGTGAGCGACG------------------ ---------------------CAGA----------AGACGGGTGATTTC--------TGC AT--TTCCATCTG-A-----GGTACCGGGTTCATCTCACTAGGG-----------AGTGC CAGA---CAGTGGGC--GCAGGTCAGTGGGTGC-G--------------CGCACCGTGCG C---------------------GAGCCGAAGCAGGGCGAGGCATTG-------------- ------------CCTCACTCG-----------------GG--AAGC--GCAAGGGGTCA- -------------GGGA---G-TTCCCTTT----CCTAG-----TCA-----AA-GAAAG GGGTGACGGACGGCAC------CTGGAAAATCGGGTCACTCCCA-CCCGAATACTGCGCT T-------------------------TTCCGACGG-GCTTAAAAAACGGC----GCACCA CGAGAT-TATATCCCGCA---CCT------------------------------------ ---G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GCTCGGAGG----- -----GTCCTACGC-CCACGGAGT-------CTCG------------------------- -------------------CTGATT-GCTAGC--------------A-----CAG----- ------------------------------------CAGTCTGAGAT------------- -------------------CAAACTGCAA-GGCGGCA--G-----CGAG----------- -GCTGGGGG------AGGGGC-------------------GCCCGCCATTGCCCAGG--- -----------------------------------------CTT--GCTTAG-------- -----------GTAAACAAAGCAGCCGGG--------------AAGCTCGAACTGG---- -------------------GTGGAGCCCACCACAG----------------CTCAAGGA- -----------------------------------GGCC--------------------- -------TGCCTG---------------CCTCTGTAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GCTCCACCTCTGGGG-----------------------GCA GG-GCACAGAC-------------------------------AAACAAA----------- --------------------------------------AAGACAGCA------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GTAAC-------------------- CTCT--------GCAGAC------------------------------------------ -TTAAATGT------CCCTGTC--TGACAGCTTTGAAGA--------------------- ---------G-A-----GCAGTG--------------GT----------------TCTCC CAG----------------------CACGCAGCTGGAGATCTGAGAACGG--------G- ---C--------AGACTGC--------CTCCTCAA---------------------GTGG GTCCCTGACCC---CTGACCCCC-----GA-----GCAGCCTA---------------AC TGGGAGGCAC--CCCCCA---------------GCAGGG------GCAC----------- -----------A-------------------------CTGACACCTCAC----------- -----ACGGCAG----------------------------GG------------------ ------T----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----A-------------CTCCA---------ACAG------------------------ -------------------------------------------A--CCTGCAGCTGAG-- -----------GGTCCTGTCTGTTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAAGGAA------------------------------AAC T-----------AACAAACAG--------------------------------------- ------------------------------------------------------------ --------------------------------------AAAGGACATCCACAC------- ------------------------------------------------------------ -----------CAAAAACC----------------------CAT---------------- -----------CTGTACATCACC------------------------------------- --ATCATCAA-AGACCAAA--------------A-------------------------- ---GTAGATAA------AACC--------------------------------------- ------------------------AC-------AAAGTGGGGAA---------------- ------AAAACAGA-------ACAGAAAAACT-------GGAAACTCTAAAAAGCAGAGC GCCTCTCCTCCTC-----CAA------------AGGAACGCAGTTCCTCA---------- CCAG---CAACGGAACAAA-------GCT-GGATGGAGAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-CTTTGACG AGCT------GAGAGAAG------AAGGC------------TTCAGACG---AT------ ----CAA---ATTACTCTGAGCT----ACGGGAGGACA---------------------- ------------------------------TTCAAACCAAAGGC---AAAGAAGT----- ----------------------------------------T------------------- -------GAAAACTTTGAAAAAAAT---TTAGAAGAATG--------------------- ----------------------TATAA-------------CTAG------AATAACCAAT --------------------------------------ACAGAGAAGTGC---------- -----TTAAAGGAGC--------------------------------------------- ------------------------TGAT-GGAGC---TGAAA---------ACCAA---- -GGCTCGAGAA----CTACGTGAAGAATGCA-------GAAG------------------ --------------------------------------------CCTCAGGAGCCGATG- -----CGATC--AACT------------------GGAAG---------AAAG-GGT-ATC AGCGATG----------------------------------------------------- ------------------------------------------------------------ ----GAAGATGAAATGAATGAAA-T--GAAGCGA------GAAG---------GGAA--- ------------------GTTTAGAGAAAAA---AGA---ATAAAAAGAAA--------- TGA-GCAAAGCCTCCAA--GAAATATGGG-ACTATGTG-----------AAAAG--ACCA AATCTACGTC-TGATTGG--TGTACCTGAAA--------------GTGATGGGGAGAATG GAACCAAGTTGG---------AAAACACTCTGCA--G--------GATATTATCCA-G-G AGAACTTCCCCAATCT--------------------AGCAAGGCAGGCCA--ACGTTCAG ATTC-----AGGAAATACAGAGAAC---GCCACA-AAGAT--------ACT--------- ---C-CTCGAGAA-----GAGCAACTCCAA----------------------------GA CACATAATTGTCAGATT------CAC-CAAAG---------TTGAAATGA---------- ------------AGG--AAAAAATGT---------------------------------- --------TAAGGGCAGCCAGAGA---GAAAGGTC--------------GGGTTAC---C CTC----------AAAG--------------GGAAGCCCAT--CAGACTAA-C--AGCGG ATC--------TCTCGGCAGAA--ACCCTA-CAAG--CCAG-AAGAGAGTG--------- ----GGG-GCCAATA-T-------TCAACA--T-TCT-TAAAGAAAAG------------ -AAT-TT--TCA--ACCCAGAA--------TTTCAT----------ATCCA--------- --GCCAAACTAAGC-----TTCA-TAAGTGA-------AGG-AGAAATAAAATACTTTAC AGACAAGC-AAATGCTGAGAGA-TTTTGTCACCACCAGGC---CTGCCCTAA-AAGAGCT CCT--------------GAAGGA----------------------AGCGC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------CAACCGGTACCAGC CGCTGC------AAAATCATGCC------A---------------AAAT-----GGTAAA ----GA------CCATCGAGACT----AGGA-------AGAAACTGC-----ATCAACTA ACGAGCAAAATAACCAGCTAACATC-------------------------------A--- ------------------------------------------------TATGACA----- --------------------GGATCAA--ATTC-ACACATAACAATAT------------ -------------TAAC-TTTAAATG-TAAATGGACT--AAATGC---TCCAATTAAAAG ACACAGAC--TGGCAAAT-TGGAT------------AAAGAGTCAAGACCCATCAG---- ---TGT-GCTGTATTCAGGAA-ACCCATCT-CACGT--GCAGAGACACACATAGGCTCAA AA--TAAAAGGA--TGGAGGA-AGATCTACCAAGCAAATGG------AAAAC-------- -------------AAAAA-AAGGCAG--GGGTTGCAATCCTAGTCTC-TGATAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAGAGAC-AAAG-AAGGCCATTACAT-- ----AATGGTAAA---GGGATCAATTCAAC--AAGAAG--------AG-CTAACTATCCT AA-----------------ATATATATGCACCCAATACAGGAGCACCCAG--ATTCATAA AGCAAGTCCTGAGTGACCTACAAAGAGACTTAGACTCCCACAC---------ATTAATAA TGGGAGACTTTAACACCCCAC-----TGTCAACATTAGACAGA----------------- ----TCAACGAGAC------AGAA-----AGTCAACAAGGATACCCAGGAATTG------ --AACTCAGCTCTGCACCAAGCGGAC-CTAATAG--ACATCTACAGAA--CTCTCCACCC CAAATCAA---CAGAATATACATTTTTTTCA-------GCACCACAC---CACACCTATT C------CAAAATTGACCACATACTTGGAAGTAAAGCTCT-------------------- -CCTCAGCAAATGTAAAAGAA--CAGAAAT----------------TATAACAA------ -ACTATCTCTCA---GACCACAGTGCAA-TCAAACTAGAACTCAGGATTA--------AG A-------------AT-CTCACTC---AAAACCGCTCAA----CTACATGGAAACTGAAC AACCTG-CTCCTGAA---TG-ACTACTG--GGTAC---ATAACGAAAT--GAA-GGCAGA AATAAAGATGTTCTTT---GAAAC------------------------CAACGAGAACAA -AGACACAAC--ATACCAGAATCTC-TGG-GACGCATTCAAAGCAGTGTGTAGAGGGAAA --TTTATAGCACTAAATGCCCACAAGAGAAAGC---AGGA--AAGATCC---AAAATTGA ------CACCCTAACATCACAATTAAA---AGAACTAGAAAA---GC---AAGAGCAAAC ACATTCAA-AAGCTAGCA------------GAAGGCAAGAAATAAC-TAAAATCAGAGCA GAACTG---AAGGAAATAGAGACACAAAAAA-CCC---TTCAAAAAATT-AATGAATCCA -GGAGC-------TGGTTTTTTGAAAGGATCAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGATAGACCG---CTAGCAA------GACT-------------- AATAAAGAAAAAAAG---A---GAGA-AGAATCAAATAGA-------------------- -----CACAA---T---------AAAAAATGATAAA------GGGGA---TATCACCACC G--------ATCC-CACAGAAATA-CAAACTACC--ATCAG---------AGAAT----- -------------------ACTACAAACAC-CTCTACGCAAATAA--AC---TAGAAAAT CTAG---AAGAAAT--GGATAAATTCCT--C---GACACA---------TAC-----ACT CTCCCA------AGACTAAACCAGGAAGAAGTTGAATCTCTGAAT--------------- --------AGACCA------A------TAACAGGATCTGAAAT----TGTGG--CAATAA -TCAATAGCTTACCAACCAAAAAGAG--TC-CAGGACC--AGATGGATTCACAGCCGAA- TTCTA------------CCAGAGGTAC----AAGGAGGAACTGGTA-CCATTC-----C- ----TTCTGAAACTATTCCAA-------TCAATAG-AAAAAGAGGG-----------AAT CCTCCCTAACTCATTTTATGAG---------GCCAGCAT---CATTCTGATACC--AAAG C-----------------------CGGGC--AGAGACA-CAAC----CA---------AA AAAGAGAATT---------------------TTA------GACCAATAT--CCT----TG ATGAACATTGAT------------------------GCAAAAATCC-TCAA--------- ------TAAAATACTGGC-AAAACG------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGCTTATCCA--CCA ----TGAT------------CAAGTGGGC-TTCATCCCTGGGA-TGCAAG---------- -------------GCTGGTTC-AAT-----ATACGC----AAATCAATAAATGTA--ATC CAGCAT---------A------TAAACAG----AGCCAAAGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAGG---CCTTTGACAA---AA TTCAACAACCCTT-------------------CATGC---------T-AAAAAC-TCTCA --ATAAATTAGGTATTGATGGGACGT-----ATTTCAAAATAAT---------------- -----------AAGAGCTAT-CTAT-GACAAACCCACAGC-----------CAATAT--C ATACTGAATGGGCAAAA-A-----CTGGAAGC-ATTC---CCTTTGAAAA----CTGGCA CAAGACAGGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTGTT---GGAAG TTCTGGCCAG--------GGCAATTAG------GCAGGAG---AAGGA--AATAAAGGGT ATTCAATTAGGAAA-------AGAGGAAGTCAAA--TTGTCCCTG-----TTTGCAGATG AC--ATGATTGTA-------TATCTAGAAAACCCC---------------ATTGT---CT CAGCCC---------AAA--ATCTCCTTAAGCT---------GATAAG--CAACTTCAGC AAAG--TC-------------------------TCAGGATACAA--------------AA TCAATGT------------ACAAAAAT----CACAAGCATTCT--TA-TACACCAA--CA ACAGACAAACAGA------------------GAGCCAAA-TCATG----AGTGAACTCCC ATTCACAATTGC-TTCAAA---GAGAATAAAATACCTAGGAATCCAACT--------TAC -AAGGGATGTGAAGGACCTCT---TCAAGGAG--AACTACAAACCACTGCTC-AAGGAAA TAAAAGA-----------GG------------------ATAC--AAAC--AAATGGAAGA ACAT------T---CCATGCTCATG------GGTAGGAAGAATC-----AATA-TCGTG- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----GGTAATTTACAGA---TTCAATGCCATCCCCATCAAGCT---------ACCAATG- CC------------TTTCTT---------------------------------------- --CACAGAATTGG---AAA------AAACTACTTTAAAG-TTCATATGGAA-------CC AAAAAAGAGCCC---GC--ATCGCCAAGTCAATCCTAAGCCAAAAGAACA---AAGC--T -------GGAGGCATCACA---CTACCTGACTTCAAACT-----ATACTACAA---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CCAA AACAGAGA------TATAGAT--CAATGGAACAGAACAGAGCCCTC------AG--AAAT AAC---GCCGCATATCTACA----ACTATC--TGATCTTT---GACAAA--CCTGA--GA AAAACAAGC--AATGG-----GGAAAGG----ATTCC--------CTATT--TAATAAAT GGTGCTG----------G-GAAAAC--TGG-C-TAGCCA---------------TATGT- AGA---------AAG--CTGAAACTGGATCCCT----TCCT---------------TACA CC--TTATACAAAAA-TCAATT-CAAGATGGATTAAAGACTTAAACGTT--AGACCTAAA ACC-AT------------------------AAAAACCCTAGAA----------------- ------GAAA--ACCTA------G---------GCA---------TTACCATTCAGGAC- --ATA-----GG-CATGGGCAAGGACTTCATGTCTAA-AACACCA-AAA----GCAATGG CAACAAAAGACAA----A------AT---TGAC--AAA-TGGGATCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTACCATC-AGAG-TGAACAG-GCAAC CTAC--AAAA--T-GGGAG--AAAATTTTC---GCAACCTACTCAT--------CTGACA AAGGGCTAA-------TATCCAGAATCTACA--ATGAA--CTCAA-----ACAAA----- ----------------------TTTACAAGAA------AAAAAC------------A--- AACAACCCCA-TCAAAA----------AGTGGGCGAA-----------GGA--CATGAAC ---AGACACTTCTCAAAAGAAGACATTTATG--------------CAGCCAAA-AAACAC ATGAAAAAATG----CTCATCATCACTGG-CCATCAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACACCAGTTAGAATGGCAA-- ----TCATTAAAA---AGTCAGGAA-----------ACAACAG--GTG--CTGGA-G--- ---------------AGGATGTGGAGAA-------------------------------- -----ATAGGAACACTTTT-ACACTGTTGG--TGGGAC---------------------- -------------TGTA-------------AACTA-GTTCAACC--------ATTGTGG- -------AAGTCA-GTGTGGCG--ATTC-CTCAGGGATCTAGAA--CTAGAAATACCA-- -TTTGA--CCCAGCCATCCCATTACTGGG-TATATA-CCCAAAGG-ACT--ATAA----- -------------------ATCATGCT-GCTAT--AAAGACACATG----------C--- ---------ACACG--TATGTTTATTGCGGCATTATT---CACAATA-GCAAAGACTT-G GA--ACCA--ACCCAAA-TGTCCAACA---ATGATAG-----ACTGGATTAA--GAAAA- TG---------------------------------------------------------- --------------------TGGCACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AATGATGAGTTCATGTCCTTT----------- ------------------------------------------------------------ -GTAGGGACATGGATGAAA-T---T----------------GGAAATCATCATTCTCAGT AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------TCGCA--AGAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAAA---- -----------------------------CCAAACAC-CGCATA--------TTC----- ------TCACT---CAT------------------------AGGTGGGAAT---TTGAAC A-------A--------------TGAGAT---------------C--------------- ------------------------------------ACATG-------------GACA-- -------CA------------------------------------------GGAAGG--- -GGAATATCACA---CTCTG-----GGGACTGTT---------GTGGGG----------- TGG-GGGGAGGG------------------------------------------------ --GGG-------AGGGAT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGC----------ATTGG-GAGATATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CCTAATG---------------------------------------------- ---------------------------------------------------CTAGAT--G ACGAGT--------------------------------------TAGTGGGT-------G CAG-----------------------------------------------------CG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CACCAGCATG-- -------------------GCACA-TGTATA--------C-------------ATATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACT-----AACCTGCAC----------------------------------------- ------AATG-TGCACA-------------------------------TGTACC------ ------------------------------------------------------------ -------------------------------------------------CTA-------- --------------AAACT------------TAAAGTA----TAATAAAAA------AA- -------AAAAAAAAAAAAAAAAAAA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA4 -------------------------GGGGTGGAGCCAAGATG--GCCGAAT-AGGAACAG CTCCAGTCTAC---AGCTCCCA--------GCGTGAGCGACG------------------ ---------------------CAGA----------AGACGGGTGATTTC--------TGC AT--TTCCAACTG-A-----GGTACCGGGTTCATCTCACTGGGG-----------AGTGT CGGA---CAGTGGGT--GCAGGACAGTGGGTGCAG--------------CGCACCGAGCG T---------------------GAGCCGAAGCAGGGCGAGGCATCG-------------- ------------CCTCACCCG-----------------GG--AAGC--GCAAGGGGTCA- -------------GGGA---A-TTCCCTTT----CCTAG-----TCA-----AA-GAAAG GGGTGACAGACGGCAC------CTGGAAAATCGGGTCACTCCCA-CCCTAATACTGCGCT T-------------------------TTCCAACGG-TCTTAGCAAACGGC----ACACCA GGAGAT-TATATCCCGCG---CCT------------------------------------ ---G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GCTCGGAGG----- -----GTCCTACGC-CCACGGAGC-------CTCG------------------------- -------------------CTCATT-GCTAGC--------------A-----CAG----- ------------------------------------CAGTCTGAGAT------------- -------------------CAAACTGCAA-GGCGGCA--G-----CGAG----------- -GCTGGGGG------AGGGGC-------------------GCCCGCCATTGCCGAGG--- -----------------------------------------CTT--GAGTAG-------- -----------GTAAACAAAGCGGCCGGG--------------AAGCTCGAACTGG---- -------------------GTGGAGCCCACCGCAG----------------CTCAAGGA- -----------------------------------GGCC--------------------- -------TGCCTG---------------CCTCTGTAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ACTCCACCTCTGGGG-----------------------GCA GG-GCATAGCC-------------------------------AAAC-AA----------- --------------------------------------AAGGCAGCA------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GAAAC-------------------- CTCT--------GCAGAC------------------------------------------ -TTAAATGT------CCCTGTC--TGACAGCTTTGAAGA--------------------- ---------G-A-----GTAGTG--------------GT----------------TCTCC CAG----------------------CACGCAGCTGGAGATCTGAGAACGG--------A- ---C--------AGACTGC--------CTCCTCAA---------------------GTGG GT-------CC---CTGACCCCC-----GA-----GTAGCCTA---------------AC TGGGAGGCAC--CCCCCA---------------GTAGGG------GCAG----------- -----------A-------------------------CTGACACCTCAC----------- -----ACGGCCG----------------------------GG------------------ ------TACTCCTCTGAGACAAAACT---------------------------------- ----------------------------------------------TCCA---------- -----------GAGGAACGAT--CAGG----------------------------CAGCA ACATTTGCTGTTCACCAATATCCG------------------CTGTTCTGCAGC--CTCC GCTGCTGAT----------ACC-------------------CAGGCAAACA--------- ------------G-GGTCTGGAG------------------------TGGACC---TCCA GCAAA-------------CTCCA---------ACAG------------------------ -------------------------------------------A--CCTGCAGCTGAG-- -----------GGTCCTGACTGTTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAAGGAA------------------------------AAC T-----------AACAAACAG--------------------------------------- ------------------------------------------------------------ --------------------------------------AAAGGACATCCACAC------- ------------------------------------------------------------ -----------CAAAACCC----------------------CAT---------------- -----------CTGTACGTCACC------------------------------------- --ATCATCAA-AGACCAAA--------------G-------------------------- ---GTAGATAA------AACC--------------------------------------- ------------------------AC-------AAAGTGGGGAA---------------- ------AAAACAGA-------GCAGAAAAACT-------GGAAACTCTAAAAATCAGAGC GCCTCTCCTCCTC-----CAA------------AGGAACGCAGCTCCTCA---------- CCAG---CAACGGAACAAA-------GCT-GGACGGAGAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-CTTTGACG AGTT------GAGAGAAG------AAGGC------------TTCAGACG---AT------ ----CAA---ACTACTCCGAGCT----AAAGGAGGAAG---------------------- ------------------------------TTCGAACCCATGGC---AAAGAAGT----- ----------------------------------------T------------------- -------AAAAACCTTGAAAAAAAA---TTAGACGAATG--------------------- ----------------------GCTAA-------------CTAG------AATAACCAAT --------------------------------------GCAGAGAAGTCC---------- -----TTAAAGGACC--------------------------------------------- ------------------------TGAT-GGAGC---TGAAA---------ACCAA---- -GGCACGAGAA----CTACGTGACGAATGCA-------CAAG------------------ --------------------------------------------CCTCAGTAGCCGATT- -----CGATC--AACT------------------GGAAG---------AAAG-GGT-ATC AGTGATG----------------------------------------------------- ------------------------------------------------------------ ----GAAGATCAAATGAATGAAA-T--GAAGCGA------GAAG---------AGAA--- ------------------GTTTAGAGAAAAA---AGA---ATAAAAAGAAA--------- CGA-ACAAAGCCTCCAA--GAAATATGGG-ACTATGTG-----------AAAAG--ACCA AATCTACGTC-TGATTGG--TGTACCTGAAA--------------GTGACGGGGAGAATG GAACCAAGTTGG---------AAAACACTCTGCA--G--------GATATTATCCA-G-G AGAACTTCCCCAATCT--------------------AGCAAGGCAGGCCA--ACATTCAA ATTC-----AGGAAATACAGAGAAC---GCCACA-AAGAT--------ACT--------- ---C-CTCGAGAA-----GAGCAACTCCAA----------------------------GA CACATAATTGTCAGATT------CAC-CAAAG---------TTGAAATGA---------- ------------AGG--AAAAAATGT---------------------------------- --------TAAGGGCAGCCAGAGA---GAAAGGTC--------------GGGTTAC---C CAC----------AAAG--------------GGAAGCCCAT--CAGACTAA-C--AGCTG ATC--------TCTCGGCAGAA--ACTCTA-CAAG--CCAG-AAGAGAGTG--------- ----GGG-GCCAATA-T-------TCAACA--T-TCT-TAAAGAAAAG------------ -AAT-TT--TCA--ACCCAGAA--------TTTCAT----------ATCCA--------- --GCCAAACTAAGC-----TTCA-TAAGTGA-------AGG-AGAAATAAAATACTTTAC AGACAAGC-AAATGCTGAGAGA-TTTTGTCACCACCAGGC---CTGCCCTAA-AAGAGCT CCT--------------GAAGGA----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------CAACCGGTACCAGC CACTGC------AAAAACATGCC------A---------------AATT-----GGTAAA ----GA------CCATCGAGGCT----AGGA-------AGAAACTGC-----ATCAACTA ACGAGCAAAATAACCAGCTAACATC-------------------------------A--- ------------------------------------------------TATGACA----- --------------------GGATCAA--ATTC-ACACATAACAATAT------------ -------------TAAC-CTTAAATG-TAAATGGGCT--AAATGC---TCCAATTAAAAG ACACAGAC--TGGCAAAT-TGGAT------------AAAGAGTCAAGACCCATCAG---- ---TGT-GCTGTATTCAGGAA-ACCCATCT-CACGT--GCAGAGACACACATAGGCTCAA AA--TAAAGGGA--TGGAGGA-AGATCTACCAAGCAAATGG------AAAAC-------- -------------AAAAA-AAGGCAG--GGGTTGCAATCCTAGTCTC-TGATAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAGAGAC-AAAG-AAGGCCATTACAT-- ----AATGGTAAA---GGGATCAATTCAAC--AAGAAG--------AG-CTAACTATCCT AA-----------------ATATATATGCACCCAATACAGGAGCACCCAG--ATTCATAA AGCAAGTCCTTAGAGACCTACAAAGAGACTTAGACTCCCACAC---------AATAATAA TGGGAGACTTTAACACCCCAC-----TGTCAACATTAGACAGA----------------- ----TCAACGAGAC------AGAA-----AGTTAACAAGGATATCCAGGAATTG------ --AACTCAGCTCTGCACCAAGCGGAC-CTAATAG--ACATCTACAGAA--CTCTCCACCC CAAATCAA---CAGAATATACATTCTTTTCA-------GCACCACAC---CACACCTATT C------CAAAATTGACCACATAGTTGGAAGTAAAGCACT-------------------- -CCTCAGCAAATGTAAAAGAA--CAGAAAT----------------TATAACAA------ -ACTGTCTCTCA---GACCACAGTGCAA-TCAAACTAGAACTCAGGATTA--------AG A-------------AA-CTCACTC---AAAACCGCTCAA----CTACATGGAAACTGAAC AACCTG-CTCCTGAA---TG-ACTACTG--GGTAC---ATAACGAAAT--GAA-GGCAGA AATAAAGATGTTCTTT---GAAAC------------------------CAACGAGAACAA -AGACACAAC--ATACCAGAATCTC-TGG-GACACATTCAAAGCAGTGTGTAGAGGGAAA --TTTATAGCACTAAATGCCCACAAGAGAAAGC---AGGA--AAGATCT---AAAATTGA ------CACCCTAACATCACAATTAAA---AGAACTAGAGAA---GC---AAGAGCAAAC ACATTCAA-AAGCTAGCA------------GAAGGCAAGAAATAAC-TAAGATCAGAGCA GAACTG---AAGGAAATAGAGACACAAAAAA-CCC---TTCAAAAAATC-AATGAATCCA -GGAGC-------TGGTTTTTTGAAAAGATCAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGATAGACCG---CTAGCAA------GACT-------------- AATAAAGAAGAAAAG---A---GAGA-AGAATCAAATAGA-------------------- -----CGCAA---T---------AAAAAATGATAAA------GGGGA---TATCACCACC G--------ATCC-CACAGAAATA-CAAACTACC--ATCAG---------AGAAT----- -------------------ACTATAAACAC-CTCTACGCAAATAA--AC---TAGAAAAT CTAG---AAGAAAT--GGATAAATTCCT--C---GACACA---------TAC-----ACC CTCCCA------AGACTAAACCAGGAAGAAGTTGAATCTCTGAAT--------------- --------AGACCA------A------TAACAGGCTCTGAAAT----TGAGG--CAATAA -TTAATAGCTTACCAACCAAAAAAAG--TC-CAGGACC--AGATGGATTCACAGCCGAA- TTCTA------------CCAGAGGTAC----AAGGAGGAGCTGGTA-CCATTC-----C- ----TTCTGAAACTATTCCAA-------TCAATAG-AAAAAGAGGG-----------AAT CCTCCCTAACTCATTTTATGAG---------GCCAGCAT---CATCCTGATACC--AAAG C-----------------------CTGGC--AGAGACA-CAAC----AA---------AA AAAGAGAATT---------------------TTA------GACCAATAT--CCC----TG ATGAACATCGAT------------------------GCAAAAATCC-TCAA--------- ------TAAAATACTGGC-AAACCG------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGCTTATCCA--CCA ----TGAT------------CAAGTGGGC-TTCATCCCTGGGA-TGCAAG---------- -------------GCTGGTTC-AAC-----ATACGC----AAATCAATAAACGTA--ATC CAGCAT---------A------TAAACAG----AACCAAAGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAGG---CCTTTGACAA---AA TTCAACAACCCTT-------------------CATGC---------T-AAAAAC-TCTCA --ATAAATTAGGTATTGATGGGACGT-----ATCTCAAAATAAT---------------- -----------AAGAGCTAT-CTAT-GACAAACCCACAGC-----------CAATAT--C ATACTGAATGGGCAAAA-A-----CTGGAAGC-ATTC---CCTTTGAAAA----CTGGCA CAAGACAGGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTGTT---GGAAG TTCTGGCCAG--------GGCAATCAG------GCAGGAG---AAGGA--AATAAAGGGT ATTCAATTAGGAAA-------AGAGGAAGTCAAA--TTGTCCCTG-----TTTGCAGATG AC--ATGATTGTA-------TATCTAGAAAACCCC---------------ATCGT---CT CAGCCC---------AAA--ATCTCCTTAAGCT---------GATAAG--CAACTTCAGC AAAG--TC-------------------------TCAGGATACAA--------------AA TCAATGT------------GCAAAAAT----CACAAGCATTCT--TA-TACACCAA--TA ACAGACAAACAGA------------------GAGCCAAA-TCATG----AGTGAACTCCC ATTCACAATTGC-TTCAAA---GAGAATAAAATACCTAGGAATCCAACT--------TAC -AAGGGATGTGAAGGACCTCT---TCAAGGAG--AACTACAAACCACTGCTC-AATGAAA TAAAAGA-----------GG------------------ATAC--AAAC--AAATGGAAGA ACAT------T---CCATGCTCATG------GGTAGGAAGAATC-----AATA-TCGTG- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----GGTAATTTATAGA---TTCAATGCCATCCCCATCAAGCT---------ACCAATG- AC------------TTTCTT---------------------------------------- --CACAGAATTGG---AAA------AAACTACTTTAAAG-TTCATATGGAA-------CC AAAAAAGAGCCC---GC--ATTGCCAAGTCAATCCTAAGCCAAAAGAACA---AAGC--T -------GGAGGCATCACG---CTACCTGACTTCAAACT-----ATACTACAA---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CCAA AACAGAGA------TATAGAC--CAATGGAACAGAACAGAGCCCTC------AG--AAAT AAT---GCCGCATATCTACA----ACTATC--TGATCTTT---GACAAA--CCTGA--CA AAAACAAGA--AATGG-----GGAAAGG----ATTCC--------CTATT--TAATAAAT GGTGCTG----------G-GAAAAC--TGG-C-TAGCCA---------------TATGT- AGA---------AAG--CTGAAACTGGATCCCT----TCCT---------------TACA CC--TTATACAAAAA-TTAATT-CAAGATGGATTAAAGACTTAAATGTT--AGACCTAAA ACC-AT------------------------AAAAACCCTAGAA----------------- ------GAAA--ACCTA------G---------GCA---------ATACCATTCAGGAC- --ATA-----GG-CATGGGCAAGGACTTCATGTCTAA-AACACCA-AAA----GCAATGG CAACAAAAGCCAA----A------AT---TGAC--AAA-TGGGATCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTACCATC-AGAG-TGAACAG-GCAAC CTAC--AGAA--T-GGGAG--AAAATTTTT---GCAATCTACTCAT--------CTGACA AAGGGCTAA-------TATCCAGAATCTACA--ATGAA--CTCAA-----ACAAA----- ----------------------TTTACAAGAA------AAAAAC------------A--- AACAACCCCA-TCAAAA----------AGTGGGCGAA-----------GGA--TATGAAC ---AGACACTTCTCAAAAGAAGACATTTATG--------------CAGCCAAA-AGACAC ATGAAAAAATG----CTCATCATCACTGG-CCATCAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACACCAGTTAGAATGGCGA-- ----TCATTAAAA---AGTCAGGAA-----------ACAACAG--GTG--CTGGA-G--- ---------------AGGATGTGGAGAA-------------------------------- -----ATAGGAACACTTTT-ACACTGTTGG--TGGGAC---------------------- -------------TGTA-------------AACTA-GTTCAACC--------ATTGTGG- -------AAGTCA-GTGTGGCG--ATTC-CTCAGGGATCTAGAA--CTAGAAATACCA-- -TTTGA--CCCAGCCATCCCATTACTGGG-TATATA-CCCAAAGG-ATT--ATAA----- -------------------ATCATGCT-GCTAT--AAAGACACATG----------C--- ---------ACACG--TATGTTTATTGCGGCACTATT---CACAATA-GCAAAGACTT-G GA--ACCA--ACCCAAA-TGTCCAACA---ATGATAG-----ACTGGATTAA--GAAAA- TG---------------------------------------------------------- --------------------TGGCACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AATGATGAGTTCATGTCCTTT----------- ------------------------------------------------------------ -GTAGGGACATGGATGAAG-C---T----------------GGAAACCATCATTCTCAGC AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------TCGCA--AGGAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAAA---- -----------------------------CCAAACAC-CGCATG--------TTC----- ------TCACT---CAT------------------------AGGTGGGAAT---TTGAAC A-------A--------------TGAGAA---------------C--------------- ------------------------------------ACATG-------------GACA-- -------CA------------------------------------------GGAAGG--- -GGAACATCACA---CACCG-----GGGCCTGTT---------GTGGGG----------- TGG-GGGGAGGG------------------------------------------------ --GGG-------AGGGAT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGC----------ATTAG-GAGATATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CCTAATG---------------------------------------------- ---------------------------------------------------TTAAAT--G ACGAGT--------------------------------------TAATGGGT-------G CAG-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CACCAACATG-- -------------------GCACA-TGTATA--------C-------------ATATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA-----AACCTGCAC----------------------------------------- ------GTTG-TGCACA-------------------------------TGTACC------ ------------------------------------------------------------ -------------------------------------------------CTA-------- --------------AAACT------------TAAAGTA----TAATAAAAA------AA- -------AAAAAAAAAAAAATAAAATAAAAAAAAAAAAAATTAAAATATATTATTATTCT TAAATACAAAATAATAATAAATAAAATATGCAACACCTTATAATATATTTGGATTATTCT TTTCTTTTAATAAAATTTCGAAATAAATAGATTTAAGAAAGAGCTAAAATACAATTATTG TAGAGAATTTTTGGAATTTTTAAATAAACATAATTGGAAAAGTATTTTCCAAGTCCTAGA TCTATTTATTCTGAAAAAGTTTAGACATTGTGATTCAGTTATAATTTAGACATATACTAC AAGGTAAATTGCATTTCTGTTAATACTATATTTTTCTAGGTATACAGTTTATAGATAAAA GGGAAAACATTTCAAAATTTAACTCAAACTTGTATAT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA5 -------------------------GGGGCGGTTCCAAGATG--GCCGAAT-AGGAACAG CTCCAGTCTAC---AGCTCCCA--------GCGTGAGCGACG------------------ ---------------------CAGA----------AGACGGGTGATTTC--------TGC AT--TTCCAACTG-A-----GGTACCGGGTTCATCTCACTGGGG-----------CTTGT CGGA---CAGTGGGT--GCAGGACAGTGGGTGCAG--------------CCCACCGAGTG T---------------------GAGCCGAAGCAGGGCGAGGCATCG-------------- ------------CCTCACCCG-----------------GG--AAGC--GCAAGGGGTCA- -------------GGGA---A-TTCCCTTT----CCTAG-----CCA-----AG-GGAAG CTGTGACAGATGGCAC------CTGGAAAATCGGGTCACTCCCA-CCCTAATACTGCGCT T-------------------------TTCCAATGG-TCTTAGCAAACGGC----ACACCA GGAGAT-TATATCCCGCG---CCT------------------------------------ ---G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GCTCGGAGG----- -----GTCCCACGC-CCACGGAGC-------CTCG------------------------- -------------------CTCATT-GCTAGC--------------A-----CAG----- ------------------------------------CAGTCTGAGAT------------- -------------------CGAACTGCAA-GGCGGCA--G-----CGAG----------- -GCTGGGGG------AGGGGC-------------------GCCCACCATTGCTGAGG--- -----------------------------------------CTT--GAGTAG-------- -----------GTAAACAAAGCGGCCAGG--------------AAGCTCGAACTGG---- -------------------GTGGAGCCCACCGCAG----------------CTCAAGGA- -----------------------------------GGCC--------------------- -------TGCCTG---------------CCTCTGTAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ACTCCACCTCTGGGG-----------------------GCA GG-GCATAGCC-------------------------------GAAC-AA----------- --------------------------------------AAGGCAGCA------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GAAAC-------------------- CTCT--------GCAGAC------------------------------------------ -TTAAATGT------CCCTGTC--TGACAGCTTTGAAGA--------------------- ---------G-A-----GTAGTG--------------GT----------------TCTCC CAG----------------------CACGGAGTTTGAGATCTGAGAATGG--------A- ---C--------AGACTGC--------CTCCTCAA---------------------GTGG GT-------CC---CTGACCCCC-----GA-----GTAGCCTA---------------AC TGGGAGGCAC--CCCCCA---------------GTAGGG------GCAG----------- -----------A-------------------------CTGACACCTCAC----------- -----ACGGCCG----------------------------GG------------------ ------TACCCCTCTGAGACGAAGCT---------------------------------- ----------------------------------------------TCCA---------- -----------GAGGAACGAT--CAGG----------------------------CAGCA ACATTTGCTGTTCAGCAATATTCG------------------CTGTTCTGCAGC--CTCC GCTGCTGAT----------ACC-------------------CAGGCAAACA--------- ------------G-GGTCTGGAG------------------------TGGACC---TCCA GCAAA-------------CTCCA---------ACAG------------------------ -------------------------------------------A--CCTGCAGCTGAG-- -----------GGTCCTGACTGTTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAAGGAA------------------------------AAC T-----------AACAAACAG--------------------------------------- ------------------------------------------------------------ --------------------------------------AAAGGACATCCACAC------- ------------------------------------------------------------ -----------CAAAACCC----------------------CAT---------------- -----------CTGTACGTCACC------------------------------------- --ATCATCAA-AGACCAAA--------------G-------------------------- ---GTAGATAA------AACC--------------------------------------- ------------------------AC-------AAAGTGGGGAA---------------- ------AAAACAGA-------GCAGAAAAGCT-------GAAAATTCTAAAAATCAGAGC GCCTCTCCCCCTC-----CAA------------AGGAACGCAGCTCCTCG---------- CCAG---CAACGGAACAAA-------GCT-GGACGGAGAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-CTTTGACG AGTT------GAGAGAAG------AAGGC------------TTCAGACG---AT------ ----CAA---ACTTCTCCGAGCT----AAAGGAGGAAG---------------------- ------------------------------TTCGAACCCATCGC---AAAGAAGC----- ----------------------------------------T------------------- -------AAAAACCTTGAAAAAAGA---TTAGACGAATG--------------------- ----------------------GCTAA-------------CTAG------AATAACCAGT --------------------------------------GTAGAGAAGTCC---------- -----TTAAATGACC--------------------------------------------- ------------------------TGAT-GGAGC---TGAAA---------ACCAT---- -GGCACGAGAA----CTACGTGACGAATGCA-------CAAG------------------ --------------------------------------------CTTCAGTAGCCGATT- -----CGATC--AACT------------------GGAAG---------AAAG-GGT-ATC AGTGATT----------------------------------------------------- ------------------------------------------------------------ ----GAAGATCAAATGAATGAAA-T--GAAGCGA------GAAG---------AGAA--- ------------------GTTTAGAGAAAAA---AGA---GTAAAAAGAAA--------- TGA-ACAAAGCCTCCAA--GAAATATGGG-ACTATGTG-----------AAAAG--ACCA AATCTACGTC-TGATTGG--TGTACCTGAAA--------------GTGACGGGGAGAATG GAACCAAGTTGG---------AAAACACTCTGCA--G--------GATATTATCCA-G-G AGAACTTCCCCAACCT--------------------AGCAAGGCAGGCCA--ACATTCAA ATTC-----AGGAAATACAGAGAAC---GCCACA-AAGAT--------ACT--------- ---C-CTCGAGAA-----GAGCAACTCCAA----------------------------GA CACATAATTGTCAGATT------CAC-CAAAG---------TTGAAATGA---------- ------------AGG--AAAAAATGT---------------------------------- --------TAAGGGCAGCCAGAGA---GAAAGGTC--------------GGGTTAC---C CAC----------AAAG--------------GGAAGCCCAT--CAGACTAA-C--AGCGG ATC--------TCTCGGCAGAA--ACTCTA-CAAG--CCAG-AAGAGAGTG--------- ----GGG-GCCAATA-T-------TCAACA--T-TCT-TAAAGAAAAG------------ -AAT-TT--TCA--ACCCAGAA--------TTTCAT----------ATCCA--------- --GCCAAACTAAGC-----TTCA-TAAGTGA-------AGG-AGAAATAAAATCCTTTAC AGACAAGC-AAATGCTGAGAGA-TTTTGTCACCACCAGGC---CTGCCCTAC-AAGAGCT CCT--------------GAAGGA----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------CAACCGGTACCAGC CACTGC------AAAAACATGCC------A---------------AATT-----GGTAAA ----GA------CCATCGATGCT----AGGA-------AGAAACTGC-----ATCAACTA ACGAGCAAAATAACCAGCTAACATC-------------------------------A--- ------------------------------------------------TATGACA----- --------------------GGATCAA--ATTC-ACACATAACAATAT------------ -------------TAAC-CTTAAATG-TAAATGGGCT--AAATGC---TCCAATTAAAAG ACACAGAC--TGGCAAAT-TGGAT------------AAAGAGTCAAGACCCATCAG---- ---TGT-GCTGTATTCAGGAG-ACCCATCT-CACGT--GCAGAGACACACATAGGCTCAA AA--TAAAGGGA--TGGAGGA-AGATCTACCAAGCAAATGG------AAAAC-------- -------------AAAAA-AAGGCAG--GGGTTGCAATCCTAGTCTC-TGATAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAGAGAC-AAAG-AAGGCCATTACAT-- ----AATGGTAAA---GGGATCAATTCAAC--AAGAAG--------AG-CTAACTATCCT AA-----------------ATATATATGCACCCAATACAGGAGCACCCAG--ATTCATAA AGCAAGTCCTTAGAGACCTACAAAGAGACTTAGACTCCCACAC---------AATAATAA TGGGAGACTTTAACACCCCAC-----TGTCAACATTAGACAGA----------------- ----TCAACGAGAC------AGAA-----AGTTAACAAGGATATCCAGGAATTG------ --AACTCAGCTCTGCACCAAGCGGAC-CTAATAG--ACATCTACAGAA--CTCTCCACCC CAAATCAA---CAGAATATACATTCTTCTCA-------GCACCACAT---CGCACTTATT C------CAAAATTGACCACATAGTTGGAAGTAAAGCACT-------------------- -CCTCAGCAAATGTAAAAGAA--CAGAAAT----------------TATAACAA------ -ACTGTCTCTCA---GACCACAGTGCAA-TCAAACTAGAACTCAGGATTA--------AG A-------------AA-CTCACTC---AAAACCGCTCAA----CTACATGGAAACTGAAC AACCTG-CTCCTGAA---TG-ACTACTG--GGTAC---ATAACGAAAT--GAA-GGCAGA AATAAAGATGTTCTTT---GAAAC------------------------CAATGAGAACAA -AGACACAAC--ATACCAGAATCTC-TGG-GACACATTTAAAGCAGTGTGTAGAGGGAAA --TTTATAGCACTAAATGCCCACAAGAGAAAGC---AGGA--AAGATCT---AAAATTGA ------CACCCTAACATCACAATTAAA---AGAACTAGAGAA---GC---AAGAGCAAAC ACATTCAA-AAGCTAGCA------------GAAGGCAAGAAATAAC-TAAGATCAGAGCA GAACTG---AAGGAGATAGAGACACAAAAAA-CCC---TTCAAAAAATC-AATGAATCCA -GGAGC-------TGGTTTTTTGAAAAGATCAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGATAGACCG---CTAGCAA------GACT-------------- AATAAAGAAGAAAAG---A---GAGA-AGAATCAAATAGA-------------------- -----CGCAA---T---------AAAAAATGATAAA------GGGGA---TATCACCACC G--------ATCC-CACAGAAATA-CAAACTACC--ATCAG---------AGAAT----- -------------------ACTATAAACAC-CTCTACGCAAATAA--AC---TAGAAAAT CTAG---AAGAAAT--GGATAAATTCCT--G---GACACA---------TAC-----ACC CTCCCA------AGACTAAACCAGGAAGAAGTTGAATCCCTGAAT--------------- --------AGACCA------A------TAACAGGCTCTGAAAT----TGAGG--CAATAA -TTAATAGCCTACCAACCAAAAAAAG--TC-CAGGACC--AGACGGATTCACAGCCGAA- TTCTA------------CCAGAGGTAC----AAGGAGGAGCTGGTA-CCATTC-----C- ----TTCTGAAACTATTCCAA-------TCAATAG-AAAAAGAGGG-----------AAT CCTCCCTAACTCATTTTATGAG---------GCCAGCAT---CATCCTGATACC--AAAG C-----------------------CTGGC--AGAGACA-CAAC----AA---------AA AAAGAGAATT---------------------TTA------GACCAATAT--CCC----TG ATGAACATCGAT------------------------GCAAAAATCC-TCAA--------- ------TAAAATACTGGC-AAACCG------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGCTTATCCA--CCA ----TGAT------------CAAGTGGGC-TTCATCCCTGGGA-TGCAAG---------- -------------GCTGGTTC-AAC-----ATACGC----AAATCAATAAACGTA--ATC CAGCAT---------A------TAAACAG----AACCAAAGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAGG---CCTTTGACAA---AA TTCAACAGCCCTT-------------------CATGC---------T-AAAAAC-TCTCA --ATAAATTAGGTATTGATGGGACGT-----ATCTCAAAATAAT---------------- -----------AAGAGCTAT-TTAT-GACAAACCCACAGC-----------CAATAT--C ATACTGAATGGGCAAAA-A-----CTGGAAGC-ATTC---CCTTTGAAAA----CTGGCA CAAGACAGGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTGTT---GGAAG TTCTGGCCAG--------GGCAATCAG------GCAGGAG---AAAGA--AATAAAGGGT ATTCAATTAGGAAA-------AGAGGAAGTCAAA--TTGTCCCTG-----TTTGCAGATG AC--ATGATTGTA-------TATTTAGAAAACCCC---------------ATCGT---CT CAGCCC---------AAA--ATCTCCTTAAGCT---------GATAAG--CAACTTCAGC AAAG--TC-------------------------TCAGGATACAA--------------AA TCAATGT------------GCAAAAAT----CACAAGCATTCT--TA-TACACCAA--TA ACAGACAAACAGA------------------GAGCCAAA-TCATG----AGTGAACTCCC ATTCACAATTGC-TTCAAA---GAGAATAAAATACCTAGGAATCCAACT--------TAC -AAGGGATGTGAAGGACCTCT---TCAAGGAG--AACTACAAACCACTGCTC-AACGAAA TAAAAGA-----------GG------------------ACAC--AAAC--AAATGGAAGA ACAT------T---CCATGCTCATG------GATAGGAAGAATC-----AATA-TCGTG- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----GGTAATTTATAGA---TTCAATGCCATCCCCATCAAGCT---------ACCAATG- AC------------TTTCTT---------------------------------------- --CACAGAATTGG---AAA------AAACTACTTTAAAG-TTCATATGGAA-------CC AAAAAAGAGCCC---GC--ATTGCCAAGACAATCCTAAGCCAAAAGAACA---AAGC--T -------GGAGGCATCACG---CTACCTGACTTCAAACT-----ATACTACAA---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CCAA AACAGAGA------TATAGAC--CAATGGAACAGAACAGAGCCCTC------AG--AAAT AAT---ACCACACATCTACA----ACCATC--TGATCTTT---GACAAA--CCTGA--CA AAAACAAGA--AATGG-----GGAAAGG----ATTCC--------CTATT--TAATAAAT GGTGCTG----------G-GAAAAC--TGG-C-TAGCCA---------------TATGT- AGA---------AAG--CTGAAACTGGATCCCT----TCCT---------------TACA CC--TTATACAAAAA-TTAATT-CAAGATGGATTAAAGACTTAAATGTT--AGACCTAAA ACC-AT------------------------AAAAACCCTAGAA----------------- ------GAAA--ACCTA------G---------GCA---------ATACCATTCAGGAC- --ATA-----GG-CATGGGCAAGGACTTCATGTCTAA-AACACCA-AAA----GCAATGG CAACAAAAGCCAA----A------AT---TGAC--AAA-TGGGATCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTACCATC-AGAG-TGAACAG-GCAAC CTAC--AGAA--T-GGGAG--AAAATTTTT---GCAATCTACTCAT--------CTGACA AAGGGCTAA-------TATCCAGAATCTACA--AAGAA--CTCAA-----ACAAA----- ----------------------TTTACAAGAA------AAAAAC------------A--- AACAACCCCA-TCAAAA----------AGTGGGCGAA-----------GGA--TATGAAC ---AGACACTTCTCAAAAGAAGACATTTATG--------------CAGCCAAC-AGACAC ATGAAAAAATG----CTCATCATCACTGG-CCATCAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACACCAGTTAGAATGGCGA-- ----TCATTAAAA---AGTCAGGAA-----------ACAACAG--GTG--CTGGA-G--- ---------------AGGATGTGGAGAA-------------------------------- -----ATAGGAACACTTTT-ACACTGTTGG--TGGGAC---------------------- -------------TGTA-------------AACTA-GTTCAACC--------ATTGTGG- -------AAGACA-GTGTGGCG--ATTC-CTCAAGGATCTAGAA--CTAGAAATACCA-- -TTTGA--CCCAGCCATCCCATTACTGGG-TATATA-CCCAAAGG-ATT--ATAA----- -------------------ATCATGCT-GCTAT--AAAGACACATG----------C--- ---------ACACG--TATGTTTATTGCGGCACTATT---CACAATA-GCAAAGACTT-G GA--ACCA--ACCCAAA-TGTCCATCA---ATGATAG-----ACTGGATTAA--GAAAA- TG---------------------------------------------------------- --------------------TGGCACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AAGGATGAGTTCATGTCCTTT----------- ------------------------------------------------------------ -GTAGGGACATGGATGAAG-C---T----------------GGAAACCATCATTCTCAGC AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------TCGCA--AGGAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAAA---- -----------------------------CCAAACAC-CGCATG--------TTC----- ------TCACT---CAT------------------------AGGTGGGAAT---TTGAAC A-------A--------------TGAGAA---------------C--------------- ------------------------------------ACTTG-------------GACA-- -------CA------------------------------------------GGAAGG--- -GGAACATCACA---CACCG-----GGGCCTGTC---------GTGGGG----------- TGG-GGGGAGGG------------------------------------------------ --GGG-------AGGGAT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGC----------ATTAG-GAGATATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CCTAATG---------------------------------------------- ----------------------------------------------------TAAAT--G ACGAGT--------------------------------------TAATGGGT-------G CAG-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CACCAACATG-- -------------------GCACA-TGTATA--------C-------------ATATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA-----AACCTGCAC----------------------------------------- ------GTTG-TGCACA-------------------------------TGTACC------ ------------------------------------------------------------ -------------------------------------------------CTA-------- --------------GAACT------------TAAAGTA----TAATAAAAA------AA- -------AAAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA8A -------------------------GGGGCGGGGCCAAGATG--GCCGACT-AGAAGCAG CGGCGTTCGGA---GGCTCCCA--------TCGAAAAAAAAC------------------ ---------------------ATAA---------TAAGCGTGTGAATCC--------TTC AC--CGGCAACCA-A-----GGTATCCAGGTTCTCTCATCAAAA-----------TTGAC TAGA---AGGCTGGC--GTG--------------A--------------CCCACGGAGAG ----------------------AAGGAAGAGCAGTGTGGTGCGGTG-------------- ------------GCCCACCTG-----------------AG--AGCC--ACACGGGGAAG- -------------GGGA---ACCCCCTCCC----CCCAG-----CCA-----AG-GGAGG CGGTGAGTGAGCGTGC------T--------------ACCCAGC-CGGGGAAACTGTGCT T-------------------------TTTCCACGGAACTGTGCAACCCAC----GGATCG GAAGATCCCACTCGCGAA---CCC------------------------------------ ---ACGCCACCGGGGCCTAGCGTCCCAACCCC------------------GGAAC-GCGC AGATTCTT------ACAGCCT---------CTCAG---------------CTGGAA---- ------------TCT-----------GC--TTAAGCCTACCGAAC--------------- ----------------------------------TCCCGG----GGG------------- --GAGGGGCGAC---------------------------CAGCACCA------------- -----GCTGCGGCT-GCCTGCTGT-------CTAAGCCATTTGAGC-------------- ---TCCTTGG----------------GGGAGG-------------GG-----CAG----- ------------------------------------CAGCCAGCACTGGGA--------- ------------CTCGCAACTGCCTAACA-C---GCT--AAGCTCCCTG----------- -GGCGGGGG------AAGGGC-------------------GGCACCCATTTCTATAG--- -----------------------------------------CTC--CAGGCT-GTGCTTT TCC--CCTGCTGGAGCCAGGGAGGCTGGA--------------CGGCTTGGTCCCA---- -------------------AGACTTGTCCCCACAG----------------CCCAACACA CC-------------GGCTGTGGCAGTCT----GCGGCC--------------------- -------AGAGTG---------------CCTCTTCAGGCCTAACCCTGA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------CCCATCCTTCCTCAGTGG-----------------------GCG GG-GCTTCCCT-------------------------------GCAG-GA----------- --------------------------------------TCTCCAATA------------- -ACTCCAGCCAGAGGCTCAGG---GACAGAATTCGG------------------A--TCT CCCTG--------------------GGCCTGAG------------------CCCC----- -------TAGGGGGAGGGGTGG-----CC------GCAGT-------------------- CTCTGTGGACCAGCAGAC------------------------------------------ -TTAGCCTC------TCCT-CC--TGGTAGTTCTGAGGAATCCGGGCAGCCCAGAC---- ---------G-A-----GT-GGG--------------TT---------------TCCCCC CAG----------------------CGAAACACACCCTCTCCACCAAGGG--------A- ---C--------AAAGTGC--------TTCGTTAA---------------------ATGG GT-------CC---TGCT-CCCC-----GT-----GCCACCCA---------------AC TGGGTGAGAC--CCTCCA---------------ACAGGG------GTTG----------- -----------T-------------------------CAGACACCCTAT----------- -----ACAGGAGCGATCCTACTGGCATCA-------GGTTGG------------------ ------TGCCCCTCGAGGTCAGAGGT---------------------------------- ----------------------------------------------CCCA---------- -----------GAAGAAGGAG--CAGG----------------------------CACCC ATCTTT-----------------G------------------CTGCTCTCCAGC--CTCC TTGAGTGAC----------ATCTCCAGGCACGGGAGCGAATCAGATGAATA--------- ------------G-GGCCTGAAG------------------------TGAACC---CCCA GCAAA-------------CTGCA---------GCAG------------------------ -------------------------------------------C--CCTACAGAAGAG-- -----------GGACCTGACTATTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AAAGAAA------------------------------AAC A-----------AACAAGCAGAAA------------------------------------ --------------------------------------------------GTGACAACAA CAGCATCAACAACAACAACAACAA--------CAACAAAAAGGC---CCCCAC------- ------------------------------------------------------------ -----------AAAAACCC----------------------CAT---------------- -----------CCAAGGGTCAGC------------------------------------- --AGCCTCAA-AGACCGAA--------------A-------------------------- ---CTAGACAA------ACTC--------------------------------------- ------------------------AC-------GAAG----------------------- -------------------------------------------ACCCAAAAGGCCAGAGT GCCTCTTCTCCTC-----CAA------------ATGATCGCAACGTCTCT---------- CCAT---CAAGGGCGCAGA-------ACT-GGACGGAGGA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TCA-GATGGACG AATT------GACAGAAG------TAGGC------------TTCAGAAG---ATGGGT-A ATAAAAA---ACTACGATGAGCT----AAAGGAGCATG---------------------- ------------------------------TTCTAACCCAATGC---AAAGAAGC----- ----------------------------------------T------------------- -------AAGAACCTTGATAAAAGG---TTAGAGGAATT--------------------- ----------------------GCTAA-------------CTAG------AATAACCAGT --------------------------------------TTAGAGAGGAAC---------- -----ATAAACGACC--------------------------------------------- ------------------------TGAT-GGAGC---TGAAA---------AACAC---- -AGCACGAGAA----CTTCGTGAAGCATACA-------CAAG------------------ --------------------------------------------TATCAACAGCCGAAT- -----CGACC--AAGC------------------AGAAG---------AAAG-GAT-ATC AGAGTTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACCACCTTACTGAAA-T--AAGACAT------GCAG---------ACAA--- ------------------GAATAGAGAAAAA---AGA---ATGAAAAGGAA--------- TGA-ACAAAGCCTCCAA--GAAATATGGG-ACTTCATA-----------AAAAG--ACCG AACCTACGAT-TGATTGG--AGTACCAGAAG--------------GAGATGGGGAGAATG GAAACAAGCTGG---------AAAACACACTTCA--G--------GATATTATCCA-G-G AGAACTTCCCCAACCT--------------------AGCAAGACAGGCCA--ACATGCAA ATTC-----AGGAAATACAGAGAAC---ACCATT-AAGAT--------ACT--------- ---C-CACGAGAA-----GATCAACCCCAA----------------------------GA CACATAATCATCAGATT------CTC-CAAGG---------TCGAAATGA---------- ------------AGG--AAAAACTGT---------------------------------- --------TAAGGGCAGCCAGAGA---GAAAGGCC--------------AGGTCAC---C TAC----------AAAG--------------GGAAGCCCAT--CAGACTAA-C--AGCAG ACC--------TCTCAGCAGAA--ACTCTA-CAAG--CCAG-AAGAGATTG--------- ----GGG-GCCAATA-T-------TCAACA--T-TCT-TAAAGAAAAG------------ -AAT-TT--TCA--ACCCAGAA--------TTTCAT----------ATCCA--------- --GCCAAACTAAGC-----TTCA-TAAGCGA-------AGG-AGAAATAAAATCCTTTCC AGACAAGC-AAATGCTGAGGGA-TTTCGTTACCACCAGGC---CTGCCCTGC-AAGAGCT CCT--------------GAAAGA----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------AAACCGGTACCAGC CACTGC------AAAAACACACC------A---------------AAAT-----AATAAA ----GA------CCAATGACACT----ATGA-------AGAAACTGC-----ATCAACTA GTGTGCAAAATAACCAAATAGCATC-------------------------------A--- ------------------------------------------------TGTGACA----- --------------------GGATCAA--ATTC-ACACATAACAATAC------------ -------------TAAC-CTTAAATG-TAAATGGGCT--AAATGC---CCCAATTAAAAG ACACAGAC--TGGCAAAT-TGGAT------------AAGGAGTCAAGACCCATCAG---- ---TGT-GCTGTATTCAGGAG-ACCCATCT-TACAT--GCAAAGACACACACAGGCTCAA AA--TAAAGGGA--TGGAGGA-AAATTTACCAAGCAAATGG------AAAGC------AA AAAAAAAAAAAAAAAAAA-AAAACAG--GGGTTGCAATCCTAGTCTC-TGACAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAAAGAC-AAAG-AAGGGCATTACAT-- ----AATGGTAAA---GGGAACAATTCAAC--AAGAAG--------AG-CTAACTATTCT AA-----------------ATATATATGCACCCAATACAGGAGCACCCAG--ATTCATAA AACAAGTTCTTAGAGACCTACAAAGAGACTTAGACTCCCACAC---------AATAATAG TGGGAGACTTTAACACCCCAC-----TGTCAATATTAGACAGA----------------- ----TCAACGAGAC------AGAA-----AATTAACAAGGATATTCAGGACTTG------ --AACTCAGCTCTGGATCAAGTGGAC-CTAGTAG--ACGTCTACAGAA--CTCTCTACCC CAAATCAA---CAGAATATACATTCTTCTCA-------GTGCCACAT---GGCACTTATT C------TAAAATCGACCACATAATTGGAAGTAAAACACT-------------------- -CCTCAGCAAATGCAAAAGAA--CTGAAAT----------------CATAACAA------ -ACAGTCTCTCA---GACCACAGTGCAA-TCAAATTAGAACTCAGGATTA--------AG A-------------AA-CTCACTC---AAAACCACACAA----TTTCATGGAAATTGAAC AACCTG-CTCCTGAA---TG-ACTCCTG--GGTAA---ATAATGAAAT--TAA-GGCAGA AATCAAGAAGTTCTTT---GAAAC------------------------CAATGAGAACAA -AGAGACAAC--GTACCAGAATCTC-TGG-GACACAGCTAAAGCAGTGTTAAGAGGGAAA --TTTATAGCACTAAATGCCCACATCAGAAAGC---TAGA--AAGATCT---CAAATCGA ------CACCCTAACATCACAATTAAA---AGAGCTAGAGAG---GC---AAGAGCAAAC TAATCCAA-AAGCTAGCA------------GAAGACAAGAAATAAC-TAAGATCAGAGAA GAATTG---AAGGAGATAGAGACACGAAAAA-CCC---TCCAAAAAATC-AATGAATCCA -GGAGC-------TGGTTTTTTGAAAAAATTAA--------------------------- -----------------------------------------------------------C AA-----AA------TAGATAGACCG---CTAGCTA------GACT-------------- AATAAAGAAGAAGAG---A---GAGA-AGAATCAAATAGA-------------------- -----CACAA---T---------AAAAAATGATAAA------GGGGA---TATCACCACT G--------ACCC-CACAGAAATA-CAAACTACC--ATCAG---------AGAAT----- -------------------ACTATAAACAC-CTCTACGCAAATAA--AC---TAGAAAAT CTAG---AAGAAAT--GGATAAATTCCT--G---GACACA---------TAC-----ACC CTCCCA------AGACTAAACCAGGAAGAAGTTGAATCCCTGAAT--------------- --------AGACCA------A------TAACAAGCTCTGAAAT----TGAGG--CAGTAA -TTAATAGCCTACCAACCAAAAAAAG--CC-CAGGACC--AGACGGATTCACAGCTGAA- TTCTA------------CCAGAAATAC----AAAGAGGAGCTGGTA-CCATTC-----C- ----TTCTGAAACTATTCCAA-------ACAATTG-AAAAGGAGGG-----------ACT CCTCCCTAACTCATTTTATGAA---------GCCAGCAT---CATCCTGATACC--AAAA C-----------------------CAGGA--AGAGACA-CAAC----AA---------AA AAAGAAAACT---------------------TCA------GGCCAATAT--CCC----TG ATGAACATCGAT------------------------GCGAAAATCC-TCAA--------- ------TAAAATACTGGC-AAACCG------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAACTTATCCA--CCA ----CGAT------------CAAGTCGGC-TTCATCCCTGGGA-TGCAAG---------- -------------GCTGGTTC-AAC-----ATACGC----AAATCAATAAACGTA--ATC CATCAC---------A------TAAACAG----AACCAAAGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAGG---CCTTTGATAA---AA TTCAACATCCCTT-------------------CATGT---------T-AAAAAC-TCTCA --ATAAACTAGGTATTGATGGAACAT-----ATCTCAAAATAAT---------------- -----------AAGAGCTAT-TTAT-GACAAACCCACAGC-----------CAATAT--C ATACTGAATGGGCAAAA-G-----CTGGAAGC-ATTC---CCTTTGAAAA----CTGGTA CAAGACAAGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTATT---GGAAG TTCTGGCCAG--------GGCAATCAG------GCAAGAG---AAAGA--AATAAAGGGT ATTCAAATAGGAAG-------AGAGGAAGTCAAG--TTGTCTCTG-----TTTGCAGATG AC--ATGATTTTA-------TATTTAGAAAACCCC---------------ATCAT---CT CAGCCC---------AAA--AACTCCTTGAACT---------GATAAG--CAACTTCAGC AAAG--TC-------------------------TCAGGATACAA--------------AA TCAATGT------------GCAAAAAT----CACAAGCATTCC--TT-TACACCAA--CA ATAGGCAAGCAGA------------------GAGCCAAA-TCATG----AATGAACTCCC ATTCACAATTGC-TACAAA---GAGAATAAAATACCTAGGAATACAGCT--------AAC -AAGGGATGTGAAGGACCTCT---TCAAGGAG--AACTACAAACCACTGCTC-AAGGAAA TAAGAGA-----------GG------------------ACAC--AAAC--AAATGGAAAA ACAT------T---CCATCCTCATG------GATAGGAAGAATC-----AATA-TCGTG- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----AGTAATTTATAGA---TTCAATGCTATTCCCATCAAACT---------ACCATTG- AC------------ATTCTT---------------------------------------- --CACAGAATTAG---AAA------AAACTATTTTAAAT-TTCATATGGAA-------TC AAAGAAGACCCC---GT--ATAGCCAAGACAATCCTAAGCAAAAAGAACA---AAGC--T -------GGAGGCATCATG---CTACCTGACTTCAAACT-----ATACTACAA---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CCAA AACAGACA------TATAGAC--CAATGGAGCAGAACAGAGACCTC------AG--AAAT AAC---ACCACACATCTACA----ACCATC--TGATCTTC---AACAAA--CCTGA--CA AAAACAAGC--AATGG-----GGAAAGG----ATCTC--------CTATT--CAGTAAAT GGTGCTG----------G-GAAAAC--TGG-C-TAGCCA---------------TATGC- AGA---------AAA--CTGAAACTGGACCCCT----TCCT---------------TACA CC--TTATACAAAAA-TTAACT-CAAGATGGATTAAAGACTTAAATGTA--AAACCCAAA ACC-AT------------------------AAAAACCCTAGAA----------------- ------GAAA--ACCTA------G---------GCA---------ATACCATTCAGGAC- --ATA-----GG-CATGGGCAAAGACTTCATGACAAA-AACGCCA-AAA----GCAATTG CAACAAAAGCCAA----A------AT---TGAC--AAA-TGGGATCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTATCATC-AGAG-TGAACAG-GCAAC CTAC--AGAA--T-GGGAG--AAAATTTTT---GCAATCTACCCAT--------CTGACA AAGGTCTAA-------TATCCAGAATTTACA--AGGAA--CTTAA-----ACATA----- ----------------------TTTACAAGAA------AAA---------------A--- AACAACCCCA-TCAAAA----------AGTGGGCAAA-----------GGA--TATGAAC ---AGACACTTCTCAAAAGAAGACATTTATG--------------TGGCCAAC-AAACAT ATGAAAAAAAG----CTCAACATCACTGA-TCATCAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACGCCAGTCAGAATGGCGA-- ----TTATTAAAA---AGTCAGGAA-----------ACAATAG--ATG--CTGGC-G--- ---------------AGGCTGTGGAGAA-------------------------------- -----ATAGGAACGCTTTT-ACACTGTTGG--TGGGAA---------------------- -------------TGTA-------------AATTA-GTTCAACC--------ATTGTGG- -------AAGACA-GTATGGCG--ATTC-CTCAAGGATCTAGAA--CCAGAAATACCA-- -TTTGA--CCCAGCAATCCCATTACTGGG-TATATA-CCCAAAGG-AAT--ATAA----- -------------------ATCATTCT-ACTAT--AAAGACACATG----------C--- ---------ACACG--TATGTTTATTGCAGCACTATT---TACAATA-GCAAAGACAT-G GA--ACCA--ACCCAAA-TGCCCATCA---ATGATAG-----ACTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AGGAATGAGATCATGTCCTTT----------- ------------------------------------------------------------ -GCAGGGACATGGATGAAG-C---T----------------GGAAGCCATCATCCTCAGC AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------ACACA--GGAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAA---- -----------------------------CCAAACAC-CGCATG--------TTC----- ------TCACT---CAT------------------------AAGTGGGAGT---TTGAAC A-------T--------------TGAGAA---------------C--------------- ------------------------------------ACATG-------------GACA-- -------CA------------------------------------------GAGAGG--- -GGAACAACACA---CACCA-----GGGCCTGTT---------GGGGGG----------- TGG-GGGGTGAG------------------------------------------------ --GGG-------AGGGA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ACTTAGAG--G ATGGGT--------------------------------------CAATAGGT-------G CAG-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCACCATG-- -------------------GCACA-CGTATA--------C-------------CTATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA-----AACCTGCAC----------------------------------------- ------GTTC-TGCACA-------------------------------TGTATC------ ------------------------------------------------------------ -------------------------------------------------CCGCTTTTTTT GTTTTTTTTTTTTTTTTTT------------TAGAAGA----AA--TAAAG------AA- -------AAA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA10 --------------------------GGGAGGGGCCAAGATG--GCCGACT-AGAAACAG CTGCAGTCGGA---GGCTCCCA--------CCGAGAAGAACG------------------ ---------------------AAAA----------CGGCGAGTGAATCC--------TGC AC--CGGCAACTG-A-----GGTATCCAGGTTCTCTCACTGGGA-----------CTGAC TAGG---CGGTTGGC--GCG--------------A--------------CCCACGGAGAG C---------------------GAGGAAAAGCAGGGTGGAGCGACG-------------- ------------GCCCACCTG-----------------GG--AGCC--ACACGGGGCAA- -------------GGGG---AGCTCCCACC----CCCAG-----CCA-----AG-GGAGG CAGTGAGTGATTGTGC------T--------------ACCCTGC-CCGGGAAACCACGCT T-------------------------TTTCCATGGATCTGTGCAACCCGC----GGATCA GGAGATCCCCCTCGTGAG---CCC------------------------------------ ---ACGCCACCAGGGCCTTGGGTCCCAAGCAC------------------AGAGCTGTGC AGATTCTC-----AGCGGCCA---------CTCGG---------------CTGGAG---- ------------ACT-----------GC--CTAAGACTACCGAGT--------------- ----------------------------------TCCCGG----GGG------------- --GAGGGGCGGC---------------------------CATCATCACT----------- ------------------------------------------------------------ ------------------------------GT-------------GG-----CTG----- ------------------------------------C---CTG----------------- -------------------CTGCCTAAGA-T--GACT--GAGTTCCTG------------ ----GGGGG------AGGGGT-------------------GGCAGCCATCACTGCAG--- -----------------------------------------CTC--CAGTCTGCTGTTTT TCC--CCTGCCGGTGCTGGGGAGACTGGG--------------TGGTTTGGACCAG---- -------------------GAGGAATTCCCCACAG----------------TGCAGCACA GC-------------GGCTGTGGCAGATC----GTGGCC--------------------- -------AGACTG---------------CCTCTTTAGGCTGGACCCTGA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------CCCATCCCTCCTCACTGG-----------------------GCG GG-GCCTCCCT-------------------------------GCAG-GA----------- --------------------------------------ATTTCAGCA------------- -ACTCCAGCCAGGGGTTTAGG---GACAGAACTCTG------------------A--TCT CCCTG--------------------GGACTGAG------------------CCCC----- -------TGGGGGGAGGGGTGG-----CC------GCGGT-------------------- CTCCACGGATCAGCAGAC------------------------------------------ -TTAGTCTT------TCCC-CC--TGCTGGCTCTGAGGAATCCGGGCAGTCCAGAT---- ---------G-A-----GT-GGG--------------AT---------------TCCCCC CAG----------------------CGCAGCGCACCCCCTCTGCCAAGGG--------GC AGCC--------AGAGTGC--------TTCGTTAA---------------------GCGG GT-------CC---CTGA-TCCC-----GT-----GCCTCCTG---------------AC TGGGTGAGAC--CCCCCA---------------ACAGGG------GTCG----------- -----------C-------------------------CAGACACCTTAT----------- -----ACAGGAGCATTCCCGCTGGCATCA-------GGTCGG------------------ ------TGCCCCTCTGGGACGGAGCT---------------------------------- ----------------------------------------------CCCA---------- -----------GAGGAAGGAG--CAGG----------------------------CAGCC ATCTTT-----------------G------------------CTGTTCTGCAGC--CTCC ACTGGTGAC----------ACCTCCAGGTGCGGGAGGGACCCAGGCGAATA--------- ------------G-GGTCTGGAG------------------------TGGACC---CCCA GCAAA-------------CCGCA---------GCAG------------------------ -------------------------------------------C--CCTACGGAAGAG-- -----------GGGCCTGACTGTTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AAAGAAA------------------------------AAC A-----------AACAAACAGAAA------------------------------------ --------------------------------------------------G--------- ---------CAACAACAACAGCAT--------CAACAAAAAAGG---CCCCCC------- ------------------------------------------------------------ -----------AAAAACCC----------------------CAT---------------- -----------CCAAAGGTCAGC------------------------------------- --AGCCTCAA-AGATCAAA--------------G-------------------------- ---CTAGATAA------ACTC--------------------------------------- ------------------------AT-------GAAGTGAGAAA---------------- ------AAATCAAT-------GCAAAAATGCT-------GAAAACTCAAAAAGCCAGAGT GCCTCTTCTCCTC-----CAA------------ATGATTGCAACACCTCT---------- CCAG---CAAGGGCACAGA-------ACT-GGGCTGAGGC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-GATGGATG AATT------GACAGAAG------TAGGC------------TTCAGAAG---GTGGGT-A ATAATGA---ACTTCGCTGAGCT----AAAGGAGCATG---------------------- ------------------------------TTCTAACCCAATGC---AAAGAAGC----- ----------------------------------------T------------------- -------AAGAACCATGATAAAACA---TTACAGGAGCT--------------------- ----------------------GTTAA-------------CCAG------AATAACCAGT --------------------------------------TTAGAGAGGAAC---------- -----ATAAATGACC--------------------------------------------- ------------------------TGAT-GGAGC---TGAAA---------AACAC---- -AACACGAGAA----CTTCACAATGCAACCA-------CAAG------------------ --------------------------------------------TATCAATAGCCAAAT- -----AGACC--AAGC------------------AGAGG---------AAAG-AAT-TTC AGAGCTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACTATCTTGCTGAAA-T--AAGACAG------GCAG---------ACAA--- ------------------GATTAGAGAAAAA---AGA---ATGAAAAGGAA--------- TGA-ACAAAACCTCCAA--GAACTATGGG-ATTATGTA-----------AAAAG--ACCA AACCTACGAC-TGATTGG--GGTACCTGAAA--------------GAGACGGGGAGAATG GAACCAAGTTGG---------AAAACATACTTCA--G--------GATATCATCCA-G-G AGAACTTCCCCAACCT--------------------AGCAAGACAGGCCA--ACATTCAA ATTC-----AGGAAATCCAGAGAAC---CCCAGT-AAGAT--------ACT--------- ---C-CATGAGAA-----GATCAACCCCAA----------------------------GA CACATAATCATCAGATT------CTC-CAAGG---------TCGAAATGA---------- ------------AGG--AAAAAATGT---------------------------------- --------TAAGGGCAGCCAGAGA---GAAAGGCC--------------AGGTCAC---C TAC----------AAAG--------------GGAAGCCCAT--CAGACTAA-C--AGCGG ACC--------TCTCAGCAGAA--ACCCTA-CAAG--CCAG-AAGAGATTG--------- ----GGG-GCCAATA-T-------TCAACA--T-TCT-TAAAGAAAAG------------ -AAT-TT--CCA--ACCCAGAA--------TTTCAT----------ATCCG--------- --GCCAAACTAAGC-----TTCA-TAAGTGA-------AGG-AGAAATAAAATCCTTTTC AGACAAGC-AAATGCTGAGGGA-ATTTGTCACCACCAGGC---CTGCCTTGC-AAGAGCT CCT--------------GAAGGA----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------AAACCATTACCAGC CACTAC------AAAAACACACT------G---------------AAGT-----AACAAA ----GA------CCAATGACACT----ATGA-------AGCAACTAC-----ATCAACAA GTCTGCAAAATAACCAGCTAGCATC-------------------------------A--- ------------------------------------------------TGTGACA----- --------------------GGATCAA--ATTC-ACACATAACAATAT------------ -------------TAAC-CTTAAATG-TAAATGGGCT--AAATGC---CCCAATTAAAAG ACACAGAA--TGGCAAGC-TGGAT------------AAAGAGTCAAGACCCATCGG---- ---TGT-GCTGTATTCAAGAG-ACCCATCT-CACGT--GCAAAGACACACATAGGCTCAA AA--TAAAGGGA--TGGAGGA-AAATTTACCAAGCAAATGG------AAAGC-------- -------------AGAAA-AAAGCAG--GGGTTGCAATCCTAGTTTC-TGACAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAAAGAC-AAAG-AAGGGCATTACAT-- ----AATGGTAAA---GGGATCAATTCAAC--AAGAAG--------AG-CTAACTATCCT AA-----------------ATATATATGCACCCAATACAGGAGCACCCAG--ATTCATAA AACAAGTTCTTAGAGACCTACAAAGAGACTTAGACTCCCACAC---------AATAATAG TGGGAGACTTTAACACCCCAC-----TGTCAATATTAGACAGA----------------- ----TCATTGAGAC------AGAA-----AATTAACAAGGATATTCAGGACTTG------ --AACTCAGCTCTGGATCAAGTGGAC-CTGATAG--ATATCTACAGAA--CTCTCCACCC AAAAACAA---CAGAATATACATTCTTCTCA-------GTGCCACAT---GGCACTTACT C------TAAAATTGATCACATAATTGGAAGTAAAACACT-------------------- -CCTCAGCAAATGCAAAAGAA--CTGAAAT----------------CATAACAA------ -ACAGTCTCTCA---GACCACAGCACAA-TCAAATTAGAACTCAAGATTA--------AG A-------------AA-CTCACTC---AAAACCACACAA----CTACATGGAAATTGAAC AACCTG-CTCCTGAA---TG-ACTCCTG--GGTAA---ATAATGAAAT--TAA-GGCAGA AATCAAGAAGTTCTTT---GAAAC------------------------CAATGAGAACAA -AGAGACAAC--GTACCAGAATCTC-TGG-GATGCAGCTAAAGCAGTGTTAAGAGGGAAA --TTTATAGCACTAAATGCCCACATCAAAAAGC---TAGA--AAGATCT---CAAATTGA ------CACCCTAACATCACAACTAAA---AGAACTAGAGAA---CC---AAGAGCAAAC AAACCCCA-AAGCTAGCA------------GAAGACAAGAAATAAC-CAAGATCAGAGCG GAACTG---AAGGAGATAGAGACAAAAAAAA-CCC---TTCAAAAAATC-AATGAATCCA -GGAGC-------TGGTTTTTTGAAAAAATTAA--------------------------- -----------------------------------------------------------T AA-----AA------TAGATAGACTA---CTAGCTA------GACT-------------- AATAAAGAAGAAAAG---A---GAGA-AGAATCAAATAGA-------------------- -----CACAA---T---------AAAAAATGATAAA------GGGGA---TATCACCACT G--------ACCC-CACAGAAATA-CAAACAACC--ATCAG---------AGAAT----- -------------------ACTATAAACAC-CTCTATGCAAATAA--AC---TAGAAAAT CTAG---AAGAAAT--GGATAAATTCCT--G---GACACA---------TAC-----ACC CTCCCA------AGACTGAACCAGGAAGAAGTTGAATCCCTGAAT--------------- --------AGACCA------A------TAACAAGTTCTGAAAT----TGAGG--CAGTAA -TAAATAGCCTACCAACCAAAAAAAG--CC-CAGGACC--AGATGGATTTACAGCTGAA- TTCTA------------CCAGAGGTAC----AAAGAGGAGCTGGTA-CCATTT-----C- ----TTCTGAAACTATTCCAA-------ACAATTG-AAAAGGAGGG-----------ACT TCTCCCTAACTCATTTTATGAG---------GCCAGCAT---CATCCTGATACC--AAAA C-----------------------CTGGC--AGAGATA-CAAC----AA---------AA AAAGAAAACT---------------------TCA------GGCCAATAT--CCC----TG ATGAACATCGAT------------------------GCAAAAATCC-TCAA--------- ------TAAAATACTGGC-AAACCG------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGCTTATCCA--CCA ----CGAT------------CAAGTCGGC-TTCATCCCCGGGA-TGCAAG---------- -------------GCTGGTTC-AAC-----ATATGC----AAATCAATAAATGTA--ATT CATCAC---------A------TAAACAG----AACTAAAGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAGG---CCTTCGATAA---AA TTCAACATCCCTT-------------------CATGT---------T-AAAAAC-TCTCA --ATAAACTAGGTATTGATGGAACAT-----ACCTCAAAATAAT---------------- -----------AAGAGCCAT-TTAT-GACAAACCCACAGC-----------CAATAT--C ATACTGAATGGGCAAAA-G-----CTGGAAGC-ATTC---CCCTTGAAAA----CTGGCA CAAGACAAGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTATT---GGAAG TTCTGGCCAG--------GGCAATCAG------GCAAGAG---AAAGA--AATAAAGGGT ATTCAAATAGGAAG-------AGAGGAAGTCAAA--TTGTCTCTG-----TTTGCAGATG AC--ATGATCCTA-------TATCTAGAAAACCCC---------------ATCGT---CT CAGCCC---------AAA--AGCTTCTTAAGCT---------GATAAG--CAACTTCAGC AAAG--TC-------------------------TCAGGATACAA--------------AA TCAATGT------------GCAAAAAT----CACAAGCATTCC--TA-TACACCAA--CA ATAGACAAGCAGA------------------GAGCCAAA-TCATG----AATGAACTCCC ATTCACAATTGC-TACAAA---GAGAATAAAATACCTAGGAATACAGCT--------AAC -AAGGGAAGTGAAGGACCTCT---TCAAGGAG--AACTACAAACCACTGCTC-AAGGAAA TCAGAGA-----------GG------------------ACAC--AAAC--AAATGGAAAA ACAT------T---CCATGCTCATG------GATAGGAAGAATC-----AATA-TCGTG- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----AGTAATTTATAGA---TTCAATGCTATTCCCATTAAACT---------ACCATTG- AC------------ATTCTT---------------------------------------- --CACAGAATTAG---AAA------AAACTACTTTAAAA-TTCATATGGAA-------CC AAAAAAGAGCCC---AT--ATAGCCAAGACAATCCTAAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACG---CTACCTGACTTCAAACT-----ATACTACAA---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CAAA AACAGACA------CATAGAC--CAATGGAACAGAATAGAGATCTC------AG--AAAT AAG---ACCGCACATCTACA----ACCATC--TGATCTTT---GACAAA--CCTGA--CA AAAACAAGC--AATGG-----GGAAAGG----ATTCC--------CTATT--TAATAAAT GGTGCTG----------G-GAAAAC--TGG-C-TAGCCA---------------TATGC- AGA---------AAA--TTGAAACTGGACCCCT----TCCT---------------TACA CC--TTATACAAAAA-TTAACT-CAAGATGGATTAAAGACTTAAATGTA--AAACCCAAA ACT-AT------------------------AAAAACCCTAGAA----------------- ------GAAA--ATCTA------G---------GCA---------ATACCATTCAGGAC- --ATA-----GG-CATGGGCAAAGATTTCATGATGAA-AACATCA-AAA----GCAATTG CAACAAAAGCAAA----A------AT---TGAC--AAA-TGGGATCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTATCATC-AGAG-TGAACAG-ACAAC CTAC--AGAA--T-GGGAG--AAAATTTTT---GCAATCTATCCAT--------CTGACA AAGGTCTAA-------TATCCAGAATCTACA--AGGAA--CTTAA-----ACAAA----- ----------------------TTTACAAGAA------AAAAAC------------A--- AACAACCCCA-TTAAAA----------AGTGGGCAAA-----------GGA--CATGAAC ---AGACACTTCTCAAAAGAAGACATTTATG--------------CGGCCAAC-AAACAT ATGAAAAAAAG----CTCAACATCACTGA-TCATTAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCATGCCAGTCAGAATGGCGA-- ----TTATTAAAA---AGTCAAGAA-----------ACAACAG--ATG--CTGGC-G--- ---------------AGGCTGTGGAGAA-------------------------------- -----ATAGGAACGCTTTT-ACACTGTTGG--TGGGAA---------------------- -------------TGTA-------------AATTA-GTTCAACC--------ATTGTGG- -------AAGACA-GTGTGGCG--ATTC-CTCAAAGACCTAGAA--CCAGAAATACCA-- -TTTGA--CCCAGCAATCCCATTACTGGG-TATATA-CCCAAAGG-AAT--ATAA----- -------------------ATCATTCT-ATTAT--AAAGATACATG----------C--- ---------ACATG--TATGTTCATTGCAGCACTATT---CACAATA-GCAAAGACAT-G GA--ATCA--ACCCAAA-TGCCCATCA---ATGATAG-----ACTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AGGAATGAGATCATGTCCTTT----------- ------------------------------------------------------------ -GCAGGGACATGGATGGAG-C---T----------------GGAAGCCATTATCCTCAGC AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------ACACA--GGAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAA---- -----------------------------CCAAACAC-CGCATG--------TTC----- ------TCACT---TAT------------------------AAGTGGGAGC---CTGAAC A-------A--------------TGAGAA---------------C--------------- ------------------------------------ACATG-------------GACA-- -------CA------------------------------------------GGGAGG--- -GGAACAACACA---CACTG-----GGGCCTGTC---------GGGGGG----------- GGGCTGGGCGGG------------------------------------------------ --GGG-------AGGGAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGC----------ATCAG-GATAAATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GCTAATG---------------------------------------------- --------CATG----CTGGGCTT----------------------AATACCTAGGT--G ATGGGT--------------------------------------TGATAGGT-------G CAG-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCACCATG-- -------------------GCACA-CGTTTA--------C-------------CTATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA-----AACCTGCAC----------------------------------------- ------GTCC-TGCACA-------------------------------TGTATC------ ------------------------------------------------------------ -------------------------------------------------CCG-------- --------------GAACT------------TAAAATA----AAATTAAAT------AA- -------AA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA11 -----------------------------------CAAGATG--GCCGATT-AGAAGCAG CTGTGGTCCGC---AGCACTCA--------CAGAGAGGAATG------------------ ---------------------AAAA---------GGGGCGAGTGAATTC--------AGC AC--CTTCAACTG-A-----AATATCCAGGTTCTCACATTGGGA-----------CTGAC TAGG---CAAACAAC--TTG--------------A--------------CCCACGGAGAA C---------------------GAAGAAAAGCAGGGGGGGGTGACG-------------- ------------GCCCACCCG-----------------GG--AGCG--GCACGGAGCCA- -------------AGGG---AACCCCCACC----CCCAG-----CCA-----AG-GGAAG CGGTGAGTGATTGTGC------G--------------ACCCCGC-CCGGGAAACCACGCT T-------------------------CTCCCATGGATCTTTGCAACCCGT----GGATCA GGAGAT-CCCCTCGTGAG---CCC------------------------------------ ---ACGCCACCAGGGCCTTGGGTCCGATACAC------------------AGAGCTGTGT GGAGTCTCGGCAGAGCAGCCG---------CTCAGGCACACACAGAGACCCAGGAG---- ------------TTTTACATACTCTGGC--CCCGGGATCCCCAGCAA------------- -----------GGCGGGAGATCCATCTGTACATATCCCTA----GGA------------- --AGGGGGCTGAA------------TCCAGGGAGCCAAGCAGCGTCATTCTGCGG----- -----GCCCCACTT-CCACGGCAC-------CTCACAAGTTAAGAC-------------- ---CCACTGGCTTGGAATTCCAGCCAGCCAGT-------------GG-----CAG----- ------------------------------------CAGGCTGGAGT------------- -------------------CTGCCTGAGA-TGGGACT--GAGTTCCCG------------ ----GGGGG------AGGGGC-------------------GGCCACCATCTCTGTGG--- -----------------------------------------TTCGGTAGACT-CAGCTGT TCCAGCCTGCCGGCTTTGGAGAATACAGA--------------TGGTCCGGACGAG---- -------------------GAAGGGTCCCCCACAA-----------------GCAGCACA GC-------------TGCTTTGCCAGATC----GTGGCC--------------------- -------AGACTG---------------CTTCTTTAAGTGGGACCCCAA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------TCCATTCCTCCTCACTGG-----------------------GCG GG-ACCTCCCT-------------------------------GTGG-GG----------- --------------------------------------GCTTCAGCC------------- -ACTCCAGCCAGGGTTCTACG---GACAGAGCTCTG------------------ATCTCT CCCTG--------------------GGACGGAG------------------CTCC----- -------TGGGGGGAGGGGCGG-----CC------ACCAT-------------------- CTCTGTGGTTCGGTCGAC------------------------------------------ -TCAGCCGT------TCCAGCC--TGCTGGCTTTGGAGAGTCCAAGCGGTCCGGAC---- ---------G-A-----GGAAGG--------------GT---------------TCCCCC CAA----------------------TGCAGCACACCTGCTCTACCAAAAA--------GC AGCC--------AGACTGC--------TTT-TTAA---------------------GCAG GT-------CC---CTGA-TCCC-----GT-----TCCTCCTG---------------AC TGGGTGAGAC--CTCCCA---------------ACAGGG------GTCT----------- -----------C-------------------------CAGCCACCTCCT----------- -----ACAGGTGCGTTCGGGCTGGCAACA-------GGTCAG------------------ ------TACCC--CTGGGACGGAGCT---------------------------------- ----------------------------------------------TCCA---------- -----------GAGGAAGGAG--CAGG----------------------------CTGCC ATCTTT-----------------G------------------CTGTTTCGCAGC--CTTC ACTGGTGAT----------ACCTCCAGGTACGGGAAAAACCGAGGCAACTA--------- ------------G-GGTCTGGAG------------------------CGGACC---CCCA GCAAA-------------CCGCA---------GCAG------------------------ -------------------------------------------C--CCTACAGTAGAG-- -----------TGGCCTGACTGTTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AAAGAAA------------------------------AAC A-----------AACAAAAAAAAA------------------------------------ --------------------------------------------------A--------- ---------AAACAACAACAACA-------------AAAAAAGA---CCCCAC------- ------------------------------------------------------------ -----------AAAAACCC----------------------CAT---------------- -----------TCAAAGGTCAGC------------------------------------- --AACCTCAA-AGATCGAA--------------G-------------------------- ---GTAGATAA------GCCC--------------------------------------- ------------------------AC-------AAAGTGAGAAA---------------- ------GAATCAAT-------GCAAAAACACT-------GAAAACTCAAAAAGCCAGAGT GCCTCTTCTCCTC-----CAA------------ATGACCACAACACCTCT---------- CCAG---CAAGGGCACAGA-------ACT-GGGCTGAGGC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-GATGGCTG AATT------GACAGAAG------TAGGC------------TTCAGAAG---GTGGGT-A ATAACGA---ACTTCGCTGAGCT----AAAGGAGCATG---------------------- ------------------------------TTGTAACCCAATGC---AAAGAAGC----- ----------------------------------------T------------------- -------AAGAATCATGATAAAACA---ATACAGGAGCT--------------------- ----------------------GATAG-------------CCAG------AATAGCCAGT --------------------------------------TTAGAGAGGAAC---------- -----ATAACTGACC--------------------------------------------- ------------------------TGAT-GGAGC---TGAAA---------AACAC---- -AACACAAGAA----CTTCACAATGCAATCA-------CAAG------------------ --------------------------------------------TATCAATAGCAGAAT- -----AGACC--AAGT------------------GGAGG---------AAAG-AAT-CTC AGAGCTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACTATCTTTCTGAAA-T--AAGACAG------GCAG---------ACAA--- ------------------GAATAGAGAAAAA---AGA---ATGAAAAGGAA--------- TGA-ACAAAACCTCTGA--GAAATATGGG-ATTATGTA-----------AAGAG--ACCG AACCTATGAC-TGATTGG--GGTACCTGAAA--------------GAGACGGGGAGAATG GAACCAAGTTGG---------AAAACATACTTCA--G--------GATATCATCCA-G-G AGAACTTCCCCAACCT--------------------AGCAAGACAGGCCA--ACATTCAA ATTC-----AGGAAATGCAGAGAAC---CCCAGT-AAGAT--------ACT--------- ---C-CATGAGAA-----GATCAACCCCAA----------------------------GA CACATAATCATCAGATT------CTC-CAAGG---------TCGAAATGA---------- ------------AAG--AAAAAATGT---------------------------------- --------TAAGGGCAGCCAGAGA---GAAAGGCC--------------AGGTCAC---C TAC----------AAAG--------------GGAAGCCCAT--CAGACTAA-C--AGTGG ACC--------TCTCAGTGGAA--ACCCTA-CAAG--CCAG-AAGAGATTG--------- ----GGG-GCCAATA-T-------TCAACA--T-TCT-TAAAGAAAAG------------ -AAT-TT--CCA--ACCCAGAA--------TTTCAT----------ATCTG--------- --GCCAAACTAAGC-----TTCA-TAAGCGA-------AGG-AGAAATAAGATCCTTTTC AGACAAGC-AAATGCTGAGGGA-ATTCGTCACCACCAGGC---CTGCCTTGC-AAGAGCT CCT--------------GAAGGA----------------------AGCAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAAGGAA-----------AAACCATTACCAGC CACTAC------AAAAACACACT------G---------------AAGT-----AACACA ----GA------CCAGTGACACT----ATGA-------AGCAACCAC-----ATAAACAA GTCTGCAAAATAACCAGCTAGCATC-------------------------------A--- ------------------------------------------------TGTGACA----- --------------------GGATCAA--ATTC-ACACATAACAATAC------------ -------------TAAC-CTTAAATG-TAAATGGGCT--AAATGC---CCCAATTAAAAG ACACAGAA--TGGCAAGC-TGGAT------------AAAGAGCCAAGACCCATCGG---- ---TAT-GCTGTCTTCAAGAG-ACCCATCT-CACGT--GCAAAGACACACATAGGCTCAA AA--TAAAGGGA--TGGAGGA-AAATTTACCAAGCAAATGG------AAAAC-------- -------------AGAAA-AAAGCAG--GGGTTGCAATCCTAGTTTC-TGACAAAACAGA CTTTAAA-CC----------AACAAAGATCAAAAAAGAC-AAAG-AAGGGCATTACAT-- ----AATGGTAAA---GGGTTCAATTCAAC--AAGAAG--------AG-CTAACTATCCT AA-----------------ATATATATGCACCCAATACAGGAGCACCCAG--ATTCATAA AGCAAGTTCTTAGAGACCTACAAAGAGACTTAGACTCCCACAC---------AATAATAG TGGGAGACTTTAACACCCCAC-----TGACAATATTAGACAGA----------------- ----TCATCAAGAC------AGAA-----AATTAACAAAGATATTCAGGACCTG------ --AACTCAGCTCTGGATCAAGTGGAC-CTGATAG--ATATCTACAGAA--CTCTCCACCC CAAAACAA---CAGAATATACATTCTTCTCA-------TCGCCACAT---GGCACTTACT C------TAAAATTGATCACATAATCGGAAGTAAAACACT-------------------- -CCTCAGCAAATGCAAAAGAA--CTGAAAT----------------CATAACAA------ -ACAGTCTCTCA---GACCACAGCACAA-TCAAATTAGAACTCAAGATTA--------AG A-------------AA-TTCACTC---AAAACCACACAA----CTACATGGAAATTGAAC AACCTG-CTCCTGAA---TG-ACTCTTG--GGTAA---ATAATGAAAT--TAA-GGCAGA AATCAAGAAGTTCTTT---GAAAC------------------------TAATGAGAACAA -AGAGACAAT--GTACCAGAATCTC-TGG-GATGCAGCTAAAGCAGTGTTAAGAGGGAAA --TTTATAGCACTAAATGCCCACATCAAAAAGC---TAGA--AAGATCT---CAAGTTAA ------CAACCTAACATCACAACTAAA---AGAACTAGAGAA---CC---AAGAGCAAAC AAACCCCA-AAGCTAGCA------------GAAGACAAGAAATAAC-CAAGATCAGAGCT GAACTG---AAGGAGATAGAGACAAAAAAAA-CCC---TTAAAAAAATC-AATAAATCCA -GGAGC-------TGTTTTTTTAAAAAAATTAA--------------------------- -----------------------------------------------------------T AA-----AA------TAGATAGACCA---CTAGCTA------GACT-------------- AATAAAGAAGAAAAG---A---GAGA-AGAATCAAATAAA-------------------- -----CACAA---T---------CAGAAATGATAAG------GGGGA---TATCACCACT G--------ACCC-CACAGAAATA-CAAACAACC--ATCAG---------AGAAT----- -------------------ACTATAAACAC-CTCTATGCACATAA--AC---TAGAAAAT CTAG---AAGAAAT--GGATAAATTCCT--G---GACACA---------TAC-----ACC CTCCCA------AGACTGAACCAGGAAGAAATTGAATCCCTGAAT--------------- --------AGACCA------A------TAATGAGTTCTGAAAT----TGAGG--CAGTAA -TAAATAGCCTACCAACCAAAAAAAG--CC-CAGGACC--AGACAGATTCACAGCTGAA- TTCTA------------CCAGAGGTAC----AAAGAAGAGCTGGTA-CCATTT-----C- ----TACTGAAACTATTCCAA-------AAAATTG-AAAAGGAGGG-----------ACT CCTCCCTAACTCATTCTATGAG---------GCCAGCAT---CATCCTGATACC--AAAA C-----------------------CTGGC--AGAGATA-CAAC----AA---------AA AAAGAAAACT---------------------TCA------GGCCAATAT--CCT----TG ATGAACATCGAT------------------------GCAAAAATCC-TCAA--------- ------TAAAATACTGGC-AAACCA------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGCTTATCCA--CCA ----CGAT------------CAAGTTGGC-TTCATCCCCGGGA-TGCAAG---------- -------------GTTGGTTC-AAC-----ATACGC----AAATCAATAAATGTG--ATT CATCAC---------A------TAAACAG----AACTAAAGACAAAAAC---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAGG---CCTTCGATAA---AA TTCAACATCCCTT-------------------CATGT---------T-AAAAAC-TCTCA --ATAAACTAGGTATTGAAGGAACAT-----ACCTCAAAATAAT---------------- -----------AAGAGCCAT-ATAT-GACAAACCCACAGC-----------CAATAT--C ATACTGAATGGGCAAAA-G-----CTGGAAGC-ATTC---CCCTTGAAAA----CCGGCA CAAGACAAGGATGC-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTATT---GGAAG TTCTGGCCAG--------GGCAATCAG------GCAAGAG---AAAGA--AATAAAGGGT ATTCAAATAGGAAG-------AGAGGAAGTCAAA--TTATCTTTG-----TTTGCAGATG AC--ATGATCCTA-------TATCTAGAAAACCCC---------------ATCGT---CT CAGCCC---------AAA--AGCTTCTTAAGCT---------GATAAG--CAACTTCAGC AAAG--TC-------------------------TCAGGATACAA--------------AA TCAATGT------------GCAAAAAT----CACTAGCATTCC--TA-TACACCAA--CA ACAGGCAAGCAGA------------------GAGCCAAA-TCATG----AATGAACTCCC ATTCACAATTGC-TACAAA---AAGAATAAAATACCTAGGAATACAGCT--------AAC -AAGGGAAGTGAAGGACCTCT---TCAAGGAG--AACTACAAACCACTGCTC-AAAGAAA TCAGAGA-----------GG------------------ACAC--AAAC--AAATGGAAAA ACAT------T---CCATGCTCATG------GATAGGAAGAATC-----AATA-TCGTG- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----AGTAATTTATAGA---TTCAATGCTATTCCCATTAAACT---------ACCATTG- AC------------ATTCTT---------------------------------------- --CACAGAATTAG---AAA------AAACTATTTTAAAA-TTCATATGGAA-------CC AAAAAAGAGCCC---AA--ATAGCCAAGACAATCCTAAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACG---CTACCTGACTTCAAACT-----ATACTACAA---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CAAG AACAGACA------CATAGAC--CAATGGAACAGAATAGAGAACTC------AG--AAAT AAG---ACCACACACCTACA----ACCATC--TGATCTTC---GACAAA--CCTGA--CA AAAACAAGC--AATGG-----GGAAAGG----ATTCC--------CTATT--TAATAAAT GGTGCTG----------G-GAGAAC--TGG-C-TAGCCA---------------TATGC- AGA---------AAA--TTGAAACTGGACCCCT----TCCT---------------TACA CC--ATATACAAAAA-TTAACT-CAAGATGGATTAAAGACTTAAATGTA--AAACCCAAA ACT-AT------------------------AAAAACCCTAGAA----------------- ------GAAA--ATCTA------G---------GCA---------ATACCATTCAGGAC- --ATA-----GG-CACGGGCAAAGATTTCATGATGAA-AATGCCA-AAA----GCAATTG CAACAAAAGCAAA----A------AT---TGAC--AAA-TGGGATCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTATCATC-AGAG-TGAACAG-ACAAC CTAC--AGAA--T-GGGAG--AAAATTTTT---GCAATCTATCCAT--------CTGACA AAGGTCTAA-------TATCCAGAGTCTACA--AGGAA--CTTAA-----ACAAA----- ----------------------TTTACAAGAA------AAA---------------A--- AACAACCCCA-TTAAAA----------AGTGGGCAAA-----------GGA--CATGAAC ---AGACACTTCTCAAAAGAAGACATACATG--------------CGGCCAAC-AAACAT ATGAAAAAAAG----CTCAACATCACTGA-TCATTAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACGCCAGTCAGAATGGCTA-- ----TTATTAAAA---AGTCAAAAA-----------ACAACAG--ATG--CTGGC-G--- ---------------AGGTTGCGGAGAA-------------------------------- -----AAAGGAATGCTTTT-ACACTGTTGG--TGGGAG---------------------- -------------TGTA-------------AATTA-GTTCAACC--------ATTGTGG- -------AAGACA-GTGTGGCG--ATTC-CTCAAAGACCTAGAG--GCAGAAATACCA-- -TTTGA--CCCAGCAATCCCATTACTGGG-TATATA-CCCAAAGG-AAT--ATAA----- -------------------ATCATTCT-ATTAT--AAAGATACATG----------C--- ---------ACGCG--TATGTTCATTGCAGCACTATT---CACAATA-GCAAAGACAT-G GA--ATCA--ACCTAAA-TGCCCATCA---ATGATAG-----ACTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AGGAACGAGATCATGTCCTTT----------- ------------------------------------------------------------ -GCAGGGACATGGATGGAG-C---T----------------GGAAGCCATTATCCTCAGC AA-------------------------------------------------------ACT A----------------------------------------------------------- ----------ATGCA--GGAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAA---- -----------------------------CCAAACAC-CGCATG--------TTC----- ------TCACT---TAT------------------------AAGTGGG------CTGAAT G-------A--------------TGAGAA---------------C--------------- ------------------------------------ACATG-------------GACA-- -------CA------------------------------------------TGGGGG--- -GGAACAACACA---CACTG-----GGGCCTGTC---------GGGGGG----------- TGGGGGGGTTGG------------------------------------------------ --GGG-------AGGGAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGC----------ATCAG-GAAGAATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GCTAATG---------------------------------------------- --------GATG----CTGGGCTT----------------------AATACCTAGGT--G ATGGGA--------------------------------------TGATCTGT-------G CAG-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCACCATG-- -------------------GCACA-CGTTTA--------C-------------CTATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA-----AACCTGCAC----------------------------------------- ------ATCC-TGCACA-------------------------------TGTACC------ ------------------------------------------------------------ -------------------------------------------------CCT-------- --------------GAACT------------TA----A----AAGTTGAAG------AA- -------AAAAA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA16 --------------------------TTTTTTTTCCAAGATG--GCGGATT-AGAGGC-- TTTTAGCATGC---CTCAGCCA--------CTTGGAAATAGC------------------ ---------------------AAGA---------TAGTGCATAAAGATC--------AAC TC--TGTGAGCTTTA------------------ATTCAAGAAGG-----------AAAAT GGGA---A-----------------------------------------TCCACTGGAAT C---------------------------ATGAAGGACACCCCAGAT-------------- ------------CCCCTTCCGGGGAG------------GAGAACACCAGCAAACAGCCC- ----------------------------CC----GTGACAGCGTCTG-----GCTGATAA AAGTGAGTGAAGCCCCAGTACATGAGAGAGGCAGAGAGCCTCCC-TCTGTGACTCACCTT T-------------------------CCACTGGGGATCTAAGCAACCCAG----GCCAAG GGAGAGCACTTTGTTTCT---CCC------------------------------------ ------------AAGCCCTGGAGCTAACTTGG------------------GGAGAGGCTT GGAGACGCTGTGAGGGAAAGA---------CACCGGGAAAAGCTG--------------- ------------------------------------------------------------ --------------------CAGGCATTTTCCCAGACCTGGGACTGGGAGCAGGACGCCA TTTTTAATCCGGGCGCATACAAAGTCAGCCATTCTTTGGTGACCCGGCAGTGTGG----- ---------------CCATGCAGGCATTTTAGTCTTGGGCCAGAGATTGGAGCGCCTGCT CTGGAGCAGGGTAGGGGCCTCCA-----CAGCCAGAACTGTGGAAAGCACCTCAG----- ------------------------------------CAGTAGGTGCTGGAATTGTGCTCT CC-----------------CCCATTGCAG------------------------------- -GCCTGGGGCAGGAGGAGAGC----------------------TGCTACAGCTGCAG--- ----------------------------------------------------------TT TCTCCTGGGTGGTGAGACTTGCAGCCAGGGCCAGCTTGGC---GACCTGGAACTGG---- ----------------TCTGCATGTGCCATTGCTGGGTGCCCCAGCCTGCTCCCCTGAGA TCGTGGTGCAGTGGGGCCCTCTCTGCTCCATGCCCAGGCAGATCTCCAGGCATTTGGAGC ACCCACTTGCCTG---------------GATCAGCAGCCTGAGCT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GCCCCACCCTTCCTGTGCAG----------AGATCTGTGTTCCGTC GGGGCCTCTCTGCTCCCCGCCCAGGCAGATCTCCAGGCATTCAGAGCAC----------- -------------------------CCGCTTACCTGGTTCAGCAGCCTGAGCCACCCCAC CCTTCCTGGACATAGATTGTGGTGCAGCAAGGCCTCTCTG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ CTCCATGCCCAGGCAGAT----------------------------------CTCCAGGC ATTTGGAGC------ACCTGCT--TGCCTGGATCAGCAGCCTGAGCCGCCCCACCCTTCC TGT--------------GCAGAG--------------ATTCTGGTGCAGGGGGGCCCTCT CTG-------------------CTCCATGCCCAGGCAGATCTCCAGGCATTC-------- ------------AGAGCAC--------CTGCTTGC---------------------CTGG TTCAGCAGCCTGAGTTGCCCCAC------------CCCTCCTGTGCAGAGATTTTGGTGC AGGGGGGCCCTACCCTCTCTGCTCCATGCCCAGGCAGATCTCCAGGCATCTGGAGCACCC ACTCTCCTGGATTAGGAGTTTAGGCTGC---------CCCCCCTCCCGTGCAGAGAACTT GGGGCGAGGAGGTTTCCCAGCCATGCCTAGGCACACCTCTGGGTGCTTGGTGGCCGCCCA CTGGATTCTCCCTCGGCGCTGGTGCTTGTGCCTGCCATCAGGGGACCTGTAGGTGGGCCT GCCTGGTCTGGCCCTGCCCATCTTGGC-------------------TCCCGCCCCCCAGG GCCCCGGGGCTGAGCAGGGAGCTCAGA----------------------------CCACT GTGCACT-----------------------------------CCATGAATCAGCCCATTG CCTGAGGCA----------ACAGAGAGCTTCTC--------CCAGTAAACA--------- ------------AGGATCAAGTA------------------------TATACCCAGCCAT GTTGG-------------CTGCA------------------------------------- ----------------------------------------------GCTATTACCTATAA GTGCCATCTACTGGCTTGTAGGTCA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACTGCACAGCC CAATATAAAACCTGCCAAAAGAAGTGCATAGGGCTATA---------------------- ------------------------------------------------------------ --------------------GAAGCAA------------------------------AGC C-----------AAAAGACCCTACCCAGCATTCTCT------------------------ ------------------------------------------------------------ -----ACAGTCACACCCCCTAGGGAGGGGGGAAAAGGAAAAAGGAAAAAAAAAAGAAAAT ATTATAGGAAAAAAAAAAAAAAAAAAAAAAGA---------------------------- -----------AAAAATCC----------------------TAC---------------- -----------CCGCATGAAAAT------------------------------------- --AATTACAA-AAATTAGA----------------------------------------- ------AGTGCCAGCGTCTCC--------------------------------------- -----------------------------------AGTGAGAAA---------------- ------GAACCAGC-------ACAAGAACTCT-------GGCAACTCTAAAAGCCAGAGT GTCTTCTTACCTC-----CAA------------ATGACCACACTAGCTCT---------- CCAG---CAATGGTTCTTA-------ACC-------AGAC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-AATGGCTG AAAT------GACAGACA------TAGAA------------TTCAGAAT---CTGGAT-G GCAAGGA---AGCTCATTGAGAT----ACAGGAGAAGG---------------------- ------------------------------TTGAAACCCAATCC---AAGGAAAC----- ----------------------------------------C------------------- ----------------AGTAAAATA---ATCCAAGAGTT--------------------- ----------------------GAAAG-------------ACAA------AATAGCCATT --------------------------------------TTAAGAAAGAAC---------- -----CAAACTGAAC--------------------------------------------- ------------------------TTCT-GGAAT---TGAAA---------AATTC---- -ACTACAAGAA----TTTCATAATACAATTG-------GAAG------------------ --------------------------------------------TATTAACAACAGAAT- -----AGACC--AAGC------------------TGAGG---------AAAG-AAT-CTC AGAGCTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACCAGTTCTTTGAAT-C--AACTCAG------TCAG---------ACAA--- ------------------AAATAAAGAAAAA---AGA---ATTTTAAAAAA--------- TGA-ACAAAACCTCTGA--GAAATATGGG-ATTATGTA-----------AAGAG--ACCA AACCTATGAC-TCATTGGGACATTCCTGAGA--------------GAGAAGGAGAGAGAG TAAGCAACTTGG---------AAAACATATTTGA--G--------GATATAGTCCA-T-G AAAATTTCCCCAATCT--------------------CGCTAGAGAGGTTG--ACATGCAA ATTC-----AAGAAATTCAGAGAAC---CCCTGC-GAGAT--------ACT--------- ---A-TACAAGAT-----GACCATCCCCAA----------------------------GA CACATAGTCATCAGATT------CAC-CAAGG---------TCAATGCAA---------- ------------AAG--AAAAAATCT---------------------------------- --------TAAAGGCAGCTAGAGA---GAAGGGTC--------------AGGTCAC---T TAC----------AAAG--------------GGAACCCCAT--CAGGCTAG-C--AGTAG ACC--------TCTCAGCAGAA--ACCTTA-CAAG--CCAG-AAGAGATTG--------- ----GGG-GCCTATT-T-------TCAGCA--T-CCT-TAAAGAAAAG------------ -AAA-TT--CCA--ACCAAGAA--------TTTCAT----------ATCCT--------- --GCCAAACTAAGC-----TTCA-TAAGTGA-------AGG-AGAAATAAAATCCTTTTC AGACAAGC-AAATGCTAAGGGA-ATTTATTACCACTAGAC---CAGCCTTAC-AAGAGGT CCT--------------TAAGGG----------------------AGTGC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAATGAA-----------AGAACAATACCTGC CACCAC------AAAAACACACT------T---------------TAAG-----TACATA ----GC------CCACAGACCCT----ATAA-------AGCAACCAC-----ACAATAGA AACTACAAAGCAACCAGCTAACAACTT--------------------------------- ------------------------------------------------CACGATA----- ------------------------CAA--AACC-TCACATATCAATAT------------ -------------TAAC-CTTGAATG-TAAATGGTCT--AAATGC---CCCACTTAAAAG GCACAGAG--TGGCAAGT-TGGAT------------AAAAAAACAAGACCCATCTA---- ---TCT-GCTGTCTTCAAGAG-ACCCATCT-CACAT--GTAATGACACCCATAGGCTCAA AG--TAAAGGGT--TGGAGAA-AGATCTATCATGCAAATGG------AAAAC-------- -------------AAAAA-AGAGCAG--GGGTCACTATTCTTATATC-AGATAAAACAGA CTTTAAA-CC----------AACAACAGTAAAAAAGGAC-AAAG-AAGGGCATTACAT-- ----AATGATAAA---GGGTTCAATTCAAC--AAGAAG--------AC-TTAACTATCCT AA-----------------ATATATATGCACCCAACATTGGAGCACCCAG--ATTCATAA AACAAGTACTTCTAGACCTACGAAAAGACTTAGACAGCCACAC---------AATAATAG TGGGGGACTTCAACACCCCAC-----TGACAGCATTAGACAGA----------------- ----TCATTGAGGC------AGAA-----AACTAACAAAGAAATTCTGGACTTA------ --AATTCGACACTTGACCAATTGGAC-CTAATAG--ACATCTACAGAA--TACTCCACCC ATCAACCA---CAGAATATACATTCTTCTCA-------TCTGCACAC---AGAACATACT C------TAAGATTGACCACATGCTCAGCCATAAAGCAAG-------------------- -TCTCAATAAATTCAAAAAAA--TTAAAAT----------------CATACCAA------ -CCATACTCTTG---GACCACAGTGGAA-TAAAAATAGAAATCAATACCA--------AG A-------------AG-ATCTCTC---AAAACCACACAA----TTACATGGAAATTAAAC AACTTG-CTCCTGAA---TG-ACTTTTG--GGTAA---ACAATAAAAT--TAA-GGCAGA AATCAAAAAATTCTTT---GAAAT------------------------AAATGAAAACAG -AGACACAAC--ATACCAAAATCTC-TGG-GATGCAGCAAAAGCAGTGTTAAGAGGAAAG --TTTATAGCACTAAATGCCTACATCAAAAAGT---TAGA--AAGATCT---CAAATTAA ------CAATCTAACATCACACCTAGA---GGAACTAGAAAA---AC---AAGAACAAAC TAACCCCA-AAGCTAGCA------------GAAGAAAAGAAATAAC-TAAAATCAGAGCA GAACTG---AATGAAATTGAGACCCAAAAAT-CCA---TACAAAGAATC-AATAAAACCA -AAAGT-------TGGTTCTTTGAAAGGATAAA--------------------------- -----------------------------------------------------------C AA-----GA------TTGATAGACCA---CTAGCTA------GATT-------------- AACAAAGAAAAAA-----A---GAGA--GATCCAAATAAG-------------------- -----CACAA---T---------CAGAAATGACAAA------GGTGA---CATTACAACT G--------ATCC-CACAGAAATA-CAAAAGATC--CTCAG---------AGACT----- -------------------ATTATGAACAC-CTCTATGCACACAA--AC---TAGAAAAT CTAG---AGGAAAT--GGATAAATTCCT--G---GAAACA---------CAC-----AAC CTCCCA------AGATTGAATCAGGAAGAAATTGAAACCCTGAAC--------------- --------AGACCA------A------TATTAAGTTCTGAAAT----TGAAT--CAGTAA -TAAAAAACCTACCAACCAAAAAAAG--CC-CTGGACC--AGATGGATTCACAGCCAAA- TTCTA------------CCAGATATAC----AAAGAAGAGCTGGTA-CCAATT-----C- ----TACTGAAACTATTCCAA-------AAAATTG-AGGAGGAGGG-----------ACT CCTCCCTAACTCATTCTATGAA---------GCCAGCAT---CACCCTGATACC--AAAA C-----------------------CTGGC--AAAGACA-CAAT----GA---------AA AAAGAAAACT---------------------ACA------GGCCAATAT--CCC----TG ATGAACATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACCA------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGTTAATTCA--CCA ----TGAT------------CAAGTAGGC-TTTATTCCTGGGA-TGCAAG---------- -------------GTTGGTTC-AAC-----ATATGC----AAATCAATAAATGTG--ATT CACCAC---------A------TAAACAG----AATTAAAAACAAAAAC---CATATGA- ----TCATCTC---AATA----------GATGCAGA-AAAAG---CTTTTGATAA---AA TCCAACATCCCTT-------------------CATGA---------T-AAAAAC-CCTCA --ACAAACTAGGCATCAAAGGAACAT-----ACCTCAAAATAAT---------------- -----------AAGAGCCAT-CTAT-GACAAACCCACAGC-----------CAACAT--C ATACTGAATGGGCAAAA-G-----CTGGAAGC-ATTC---CCCTTGAGAA----CTGGAA CAAGACAAGGATGC-------CCACTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATCAG------GCAAGAG---AAAGA--AATAAAAGGC ATCCAAATAGGAAA-------AGAAGAAGTCAAA--CTATCTCTC-----TTCACTGATG AT--ATGATTCTA-------TACCTAGAAAACCCT---------------AAAGA---CT CTGCCA---------AAA--GGCTCCTAGAACT---------GATAAA--CAACTTCAGT AAAG--TT-------------------------TCAGGATACAA--------------AA TCAATGT------------ACAAAAAT----CAGTAGCATTTC--TA-TACACCAA--TA ACATTCAAGCTGA------------------GAGCCAAA-TCAAG----AATGCAATCCC ATTTACAATAGC-CACAAA---AAAAATAAAATACCTAGGAATACATCT--------AAC -CAAGGAGGTGAAAGATCTCT---ACAAGGAG--AACTACAAAACACTGCTG-AAAGAAA TCATAGA-----------TG------------------ACAC--AAAC--AAATGGAAAA ACAT------T---CCATGCTCATG------GATTGGAAGAATC-----AATA-TTGTT- ------------------------AAAATGGCCA-TA-CTGCCC-AA------------- ----AGCAATCTACAGA---TTCAATGCTATTCCTATCAAACT---------ACCAATG- TC------------ATTTTT---------------------------------------- --CACAGAATTAG---AAA------AAACTATTCTAAAA-TTCATATGGAA-------CC AAAAAAGAGCCC---AA--ATAGCCAAAGCAATCCTAAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACA---TTACCTGACTTCAAACT-----ATACTATAA---GGCT ACAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CAAA AACAGACA------CATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAT AAA---GCCACACACCTACA----ACCATC--TGATCTTT---GACAAA--GTTGA--CA AAAATAAGC--AATGG-----GGAAAGG----ACTCC--------CTATT--CAATAAAT GGTGCTG----------G-GATAAC--TGG-C-TAGCCA---------------TATGC- AGA---------AGA--ATGAAACTGGACCCCT----ACCT---------------TTCA CC--ATATACAAAAA-TTAACT-CAAGATGGATTAAAGATTTAAATGTA--AGACCTCAA ACT-AT------------------------AAGAATCCTAGAA----------------- ------GAAA--ACCTA------G---------GAA---------ATACCATTCTGGAC- --ATT-----GG-CCTTGGGAAAGAATTTATGACTAA-GTCCTCA-AAA----GCAATTG CAACAAAAACAAA----A------AT---TGAC--AAG-TGGGACCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTATCAAC-AGAG-TAAACAG-ACAAC CTAC--AGAA--T-GGGAG--AAAATATTC---ACAAACTATGCAT--------CTGACA AAGGTCTAA-------TATCCAGAATCTATA--AGGAA--CT--------TCAAT----- ----------------------TCAACAAGCA------AAAAAC------------A--- AATAACCCCA-TTAAAA----------AGTGGGCAAA-----------AGA--CATGAAC ---AGACACTTCTCAAAAGAAGACATACAAG--------------TGGCCAAC-AAACAT ATGAAAAAATG----CTCAACATCACTAA-TCATCAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACACCAGTCAGAATGGCTA-- ----TTATTAAAA---AGTCAAAAA-----------ACAACAG--ATG--TTGGG-G--- ---------------AGGCTGTGGAGAA-------------------------------- -----AAGGGAATGCTTAT-ACACTGTTGG--TGGGAA---------------------- -------------TGTA-------------AATTA-GTTCAGCC--------ACTGTGG- -------AAAGCA-GTTTGGAG--ATTT-CTCAAAGAACTTAAA--ACAGAACTACCA-- -TTTGA--CCCAGCAATCCCATTACTGGG-TATATA-CCCAAAAG-AAA--ATAA----- -------------------ATCATTCT-ACCAA--AAAGACACATG----------C--- ---------ACTCA--TATGTTCATCACAGCACTATT---CACAATA-GCAAAGACAT-G GA--ATCA--ACCTAGG-TGCCCATCA---ATGGTGG-----ATTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTACATAT----ACACCATGGAATAC--TATGCA-GCC ATAAAA----------------------AAGAATAAAATCATGTCCTTT----------- ------------------------------------------------------------ -GCAGCAACATGGATGCAG-C---T----------------GGAGGCCATTATCCTAAGC AA-------------------------------------------------------ATT A----------------------------------------------------------- ----------ATGCA--GGAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAA---- -----------------------------CCAAATAC-CACATG--------TTC----- ------TCACT---TAT------------------------AAGTGGG------CTAAAC A-------T--------------TGGGTA---------------C--------------- ------------------------------------TCATG-------------GACA-- -------TA------------------------------------------AAGATG--- -GCAACAATAGA---CACTG-----GGGACTACT---------AGAGGG----------- -GGGAGGGAGGG------------------------------------------------ --AGG--------GGGGC------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGG----------------GTTGAAAA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ACTATTG---------------------------------------------- --------GGTA----CTATGCTC----------------------ACTACCTGGGT--G ATGGGA--------------------------------------TCATTTGT-------A CCC-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCTCAGCA-- -------------------TCATGCAATATA--------C-------------CCATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA------------------------------------------------------- ------AACC-TGCACA-------------------------------TGTACC------ ------------------------------------------------------------ -------------------------------------------------CCT-------- --------------GAATC------------TAAAATA----AAAGTTGAA------AT- -------AAAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PA17 ---------------------------TTTTTTTCCAAGATG--GCTGACT-AGGGACAT CAGATGCTCGC---CATTCTCT--------GAAAGGGGATC------------------- ---------------------TAAG---------TTATCGGTTAAAGTA--------CCA GT--TTTGGATGGTA-----------------AACTGTGGGAAG-----------AGAGC CAGG---AGATGGCGGCGTG-----------------------------CCCATGGGAAA AACCT-----------------GGGGTGTAGAAAGGGAAAGCTGAG-------------- --------------------------------------AG--AGCTTGGCGGAGACACAC TGCGT--------TGGGCCCCGGAGGCGCC----CAGAGACCCTACT-----GAAGGGAA GAGTGCGGGGGGGATC------C--------------TCGCTGC-TCCGCATTCCGCCCC C---------------------------------GCCCCCCGCCTATGGC----TCAACT GGTAGTGCGCACCTCTGCCCACCT------------------------------------ ---AACCCAGGGTAGCATTGTTG---------------------------GTGGCGATTG GGGAACTTGCCGAGAAAACAG--------------------------------------- ------------------------------------------------------------ --------------------------------------------GAACCGGTTGCCTGGT CTTGCGGGCAGGATGTGGCTCGCTCCTC------------------GCCTCCCGCGTCCG GCGTTGTCCTGTGTGCTGCGCAGCAGTAGTTCCTAGGGGGTGCATCTCTCCTGCACGGCG GTACTCCCCCCTTGAGACACCGCACGACCA------------------------------ ------------------------------------TAGCCCCCGTAAACATACCTCA-- -------------------CAACTTGCTCTCACTTTGGCGACCTCAGGGT---------- -GCCTGCGGGACCCTGGGGGCCCGCTGTGCGGACTAGGAGGGTGGGAGTCTCCGGT---- -----------------------------------------CCCCTGGAGATCTAACCCT CGGTGTGGACTGCCCCTAAGGGAGGGGGGGGTGCAGCCCCCCAAAGCCCCCCTTGGGTCA AAGGAAATGTGGGT-----GTGGCGCCAGCCGCTGAAGGGGGCACCACCAAAGCCTGGGA AT-------------GGACATGGAGAGGGGGTGGGGGGT--------------------- ----------------------------TCTCCCCTT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------CCCCCCCCCCCCCCTCCTCAGTGC-----------------------ACT GTTGCGGATTCGGCAGTGGCTCTTCCCACTGGGGCCTGGTGAGCGTGGGCTGGAAAAGGC TGCTTCTCAGGCTTCTCCAGTGGCTCCACCCCCGCTGAAGGTGAATACGAGCTGGCGGGG GCCTTTTTCCTGGTTTCTGCTTTGCC---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ CCCCCCCCCTACACAGAGT----------------------------------------- ---------------CACAGCA--CCAGGGCCCTGGCAA--------------------- ---------GAAAGGGCGGA-----------------CATGCCCCGGAGTTGCCTGCCCT CGA----------------------CAGGGGGAAGCTGCTCTGCCCTCCACCCATTTTGC TGGT--------GGCCCCCAGGGGGGACTATCCACTGCCCACGGCCTACCGCCAGCCTGG GGCCGGGAACC---AAGGGCCAG-----AAGCCATGTGACTTG---------------AA GGACATGCGC--GCCCCGTGACAGGGGTGTGATAGGGAAGTGGA---------------- -------------------------------------TTGCCCTCTTGCTGGCTCAGGAT GAGGAGCTGGTGCACCCCCCCCCCCCATTCCCCCCAAACCTT------------------ ------CCCCCCTGCCTTTCCCCTCCCCTGCCTCCCT----------------------- ----------------------------------------------TCTGCTCCTCTCCC CCCCCCATCGAGAGCAGAATTTGCAGGTTT-------------------------CATCT GCCTACGACCCTATCTGCTGGCTC------------------TTACTCTTAAGTGCCATC TACTGGACT--------------------------------------------------- ------------GCAGCCTGAAT------------------------TACACCA--CCAA ACAAAAATACATTG----CTACA---------ACAA------------------------ ----------------------------------------------GCAATATCTGAGAA AGCCACTGCATGAACCTATCTGCAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------CCAGGAACCCGTACAGAGCCTTGGCCCTCTGAAAGCACCCA---- ------------------------------------------------------------ --------------------GAAATGA------------------------------AGC C-----------AATCGATTATACACAACATACACC------------------------ ------------------------------------------------------------ -----ACAGTCATACCCTCAAGGG-----------AAAAAAGAATAAAAAATCA------ ------------------------------------------------------------ -----------AAAAGCCC----------------------CAT---------------- -----------CCAAATGATAGC------------------------------------- --AAATTCAA-AAAAAAAA----------------------------------------- ---AAAAA---------------------------------------------------- ---------------------------------AAAAAAAAGAA---------------- ------GCATCAGCTCCCTCAGTAAGAACTCA-------GGCAATACAAAAAGCCAGAGT GTTTAAACACCTC-----CAA------------AGGATCCCACTAGCTCC---------- CTAG---CAATGGATCCTA-------ACC-------AGAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA-AATGTCTG AAAT------GACAGATA------TAGAA------------TTCAGAAT---ATGGAT-G GCAAGGA---AACTCAATGAGAT----CCAAGAGAAAG---------------------- ------------------------------TTGAAATCCAATAC---AAAGAAAC----- ----------------------------------------C------------------- ----------------AGAAAAATA---ATCCAAGATTT--------------------- ----------------------GAAAG-------------ATAA------CATAGCTATA --------------------------------------TTAAGAAAGAAC---------- -----CAAACAGAAC--------------------------------------------- ------------------------TTCT-GGAAA---TGAAA---------AATTC---- -ACTAAAGGAA----TTTCAAAATACAGTTG-------GAAG------------------ --------------------------------------------CTTTAACAATAGACT- -----AGACC--AAGC------------------AGAAG---------AAAG-AAT-TTC AGAGCTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACTAGTCTTTCAAAT-T--AACCCAG------TCAA---------AAAA--- ---------------------TAAAGAAAAA---AGA---ATTTTAAAAAA--------- TGA-ACAAAGCCTTTGA--GAAATATGGG-ATTATGTA-----------AAGTG--ACCA AACCTATGAC-TTATTGG--CATTCCTGAGA--------------GAGA---AGAAAAAG TAAGCAACTTGG---------AAAACATATTTGA--G--------GGAATAATTCA-G-G AAAATTTCCCTAATCT--------------------TGCTAGAGAGGTAG--ACATCCAG ATAC-----AAGAAATTCAGAGAAC---ACCTGC-AAGAT--------ACT--------- ---A-TACAAGAT-----GACCATCCCCAA----------------------------GG CACATAGTCATCAGACT------ATC-CAAGG---------TCAATGTAA---------- ------------AAG--AAAAAATCT---------------------------------- --------TAAAGGCAGCTAGAGA---AAAGGGTC--------------AAATTAC---C TAT----------AAAG--------------GAAATCCCAT--CAGACTAA-C--AGCAG ACT--------TCTCAGCAGAA--ACCTTA-CAAG--CCAG-AAGAGATTG--------- ----GGG-GTCTATT-T-------TTAGCC--T-TCT-TAAAAAAAAA------------ -AAA-TG--CCA--GCCAAGAA--------TTTTAT----------ATCCT--------- --GCCAAACTAAGC-----TTCA-TAAATGA-------AGG-AGAAATAAAGTCTTTCCC AGACAAGC-AAATGCTAAGGGA-ATTTATCACCACCAGAC---CAGCCCTAC-AAGAAAT GCT--------------CAAAGG----------------------AGTTC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ----------------------------AAATGAA-----------AGAAAAATACATTC TCCCAC------AAAAACACAATGAAAGAATGATACTGCTACCACAAAAGCACACATAAG ----TACATAGCCCACAGACCCT----ATAA-------AGCAACTAC-----ACAATTGA GACTACAAAGCAACTAGCTAACAAC-------------------------------A--- ------------------------------------------------CTTGACA----- --------------------GGAACAA--AACC-TCACATATCAATAT------------ -------------TAAC-CTTGAATG-TAAATGGCCT--AAATGC---TCCACTTAAAAG ACATAGAG--TGGCAAAT-TGGAT------------TAAAAAACAAGACCCAACCT---- ---TCT-GCTGCCTTCAAGAG-ACCCATCT-CACAT--GTAATGACACCCATAGGCTCAA AG--TAAAGGGA--TGGAGAA-AGATCTATCATGCAAATGG------AAAAC-------- -------------AAAAA-AGAGCAG--GGGTTGCTATTCTTGTATC-AGATAAAACAGA CTTTAAA-CC----------AACAACAGTAAAAAAAGAC-AAAG-AAGGGCATTATAT-- ----AATGATTAA---AGGTTCAATAAGAC--AAGAAG--------AT-TTAACTATCCT AA-----------------ATATATATGCACCCAACATTGGAGCACCCAG--ATTTATAA AACAAATACTACTAGACCTTAGAAAAGAGATAGATAGCCATAC---------AATAATAG TGGGGGACTTCAACACCCCAC-----TGACAGCACTAGACAGA----------------- ----TCATTGAGGC------AGAA-----AACTAACAAAGAAACTCTGGACTTA------ --AATTGGACTCTTGACCAAATGGAC-CTAATAG--ACATCTACAGAA--TACTCCACCC AACAACCA---CAGAATATACATTCTTCTCA-------TCTGCACAT---GGAACATTCT C------TAAAATTGACCACATGCTTGGTCATAAAGCAAG-------------------- -TCTCAATAAATTCAAAAAAA--TTGAAAT----------------CATATCAA------ -GCATCTTCTCA---GACCACAGTGGAA-TAAAATTAGAAATCAATACCA--------AG A-------------GG-AACTCTC---AAAACCACACAA----ATACATGGAAACTAAAC AACTTG-CTCCTGAA---TG-ACTTTTG--GGTAA---ACAATAAAAT--TAA-GGCAGA AATCAAAAAATTTTTT---GAAAC------------------------AAATGAAAATAG -AGACACAAC--ATACCAAAACCTC-TGG-GATACAGCAAAAGCAGTGTTAAGAGGAAAG --TTTATAGCACTAAATGCCTACATCAAAAAGA---TAGA--AAGATCT---CAAATTAA ------CAACCTAACATCACACCTAAA---GGAACTAGAAAA---AC---AAGA---AAC TAAACCCA-AAGCTAGCA------------GAAGAAAAGAAATAAC-TAAGATCAGAGCA GAACTA---AATGAAATTGAGACCAAAAAAA-CAA---TACAAAGGATC-AATGAAATAA -AAAGT-------TGGTTCTTTGAAAGGATAAA--------------------------- -----------------------------------------------------------C AA-----GA------TTGATAGACTA---CTAGCTA------GATT-------------- AACCAAGAAAAAAAG---A---GAGA-AGATTCAAATAAG-------------------- -----CACAA---T---------CAGAAATGACAAA------GGTGA---CATTACAACT G--------ATCC-CACAGAAATA-CAAAAGATC--CTCAG---------AGACT----- -------------------ACTATGAACAT-CTCTATGCACACAA--AC---TAGAAAAT CTAG---AGGAAAT--GGATAAATTCCT--G---GAAACA---------CAC-----AAC CTCCCA------AGATTGAACCAGGAAGAAATTGAAATCCTGAAC--------------- --------AGACCA------A------TAACGAGTTATGAAAT----TGAAT--CAGTAA -TAAAAAACCTACCAACCAAAAAAAG--CC-CTGGACC--AGATGGATTCACAGCCAAA- TTCTA------------CCAGATGTAC----AAAGAAGAGCTGGTA-CCAATC-----C- ----TACTGAAACTATTCCAA-------AAAATTG-AGGAGGAGGG-----------ATT CCTCCCTAACTCATTCTATGAA---------ACCAGTAT---CATCCTGATACC--AAAA T-----------------------CTGGC--AAAGACA-CAAC----AA---------AA AAAGAAAACT---------------------ACA------GGCCAATAT--CCC----TG ATGAACATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACCA------------------AA--T------------ ---C-CA--GCA-------------GCACATC---------AAAAAGATAATTCA--CCA ----TGAT------------CAAGTGGGC-TTTATTCCTGGGA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATGC----AAATCAATAAATGTG--ATT CACCAC---------A------TAAACAG----AATTAAAAACAAAAAC---CATATGA- ----TCATCTC---AATA----------GATGCAGA-AAAAG---CATTTGATAA---AA TCCAACATCCCTT-------------------CATGA---------T-AAAAAC-CCTCA --ACAAACTAGGCATCAAAGGAACAT-----ACCTCAAAATAAT---------------- -----------AAGAGCCAT-CTAT-GACAAACCCACAGC-----------CAACAT--C ATACTGAATGGGCAAAA-G-----TTGGAAGC-ATTC---CCCCTAAGAA----CTGGAA CAAGACAAGGATGT-------CCACTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATCAG------GCAAGAG---AAAGA--AATAAAAGGC ATCCAAATAGGAAA-------AGAGGAAGTCAAA--TTATCTCTC-----TTCACTGATG AT--ATGATTCTA-------TACCTAGAAAACCCT---------------AAAGA---TT CCGCCA---------AAA--GACTCCTAGACCT---------GATAAA--CGACTTCAGT AAAG--TT-------------------------TCAGGATACAA--------------AA TCAATGT------------ACAAAAAT----CAGTAGCATTTC--TA-TACACCAA--TA ACATTCAAGCTGA------------------GAACCAAA-TCAAG----AACTCAATCCC ATTTACAATAGC-CACAAA---AAAAATAAAATACCTAGGAATACATCT--------AAC -CAAGGAGGTGAAAGATCTCT---ACAAGGAG--AACTACAAAACACTGCTG-AAAGAAA TCATAGA-----------TG------------------ACAC--AAAC--AAATGGAAAA ACAT------T---CCATGCTCATG------GATTGGAAGAATC-----AATA-TCATT- ------------------------AAAATGACCA-TA-CTGCCC-AA------------- ----AGCAATCTACAGA---TTCAATGCAATTCCTATCAAATT---------ACCAATG- TC------------ATTTTT---------------------------------------- --CACAGAATTAGA--AAA------AAACAATTCTAAAA-TTCATATGAAA--------C AAAAAAAAGCCC---AA--ATAGCCAAAGCAATCCTAAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACA---TTACCTGACTTCAAACT-----ATACTACAA---GGCT ATAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------CAAA AATAGACA------CATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAT AAA---GCCACACACCTACA----ACCAAC--TGATCTTC---GACAAA--GTCAA--CA AAAATAAAC--AATGG-----GGAAAGG----ACACC--------CTATT--CAATAAAT GGTGCTG----------G-GAAAAC--TGG-C-TAGCCA---------------TATGC- AGA---------AGA--ATGAAACTGGACCCCT----ACCT---------------CTCA CC--ATATACAAAAA-TTAACT-CAAGATGGATTAAAGACTTAAATGTA--AGACCTCAA ACT-AT------------------------AAAAATCCTAGAA----------------- ------GAAA--ACCTA------G---------GAA---------ATACTCTTCTGGAC- --ATT-----GG-CCTAGGCAAAGAATTTATGACTAA-GTCCTCA-AAA----GCAAATG CAACAAAAACAAA----A------AT---TGAC--AAT-TGGGACCTA--AT-------- -------------------------------------------------------T-AAA CTAAAGAGCTT-CTGCA---CAGC-AAAAGAAACTATCAAC-AGAG-TAAACAG-ACAAC CTAC--AGAA--T-GGGAG--AAAATATTT---GCAAACTATGCAT--------CCAACA AAGGACTAA-------TATCCAGAATCTATA--AGGAA--CTTAA-----ACAAA----- ----------------------TCAACAAGAA------AAAAAA------------A--- AAAAACCCCA-TTAAAA----------AGTGGGCAAA-----------GGA--CATGAAC ---AGACACTTCTCAAAAGAAGACATACAAG--------------CAGCCAAC-AAACAT ATGAAAAAATG----CTCAACATCACTAA-TCATCAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCATCTCACACCAGTCAGAATGGCTA-- ----TTATTAAAA---AGTCAAAAA-----------ATAACAG--ATG--TTGGC-A--- ---------------AGGATGTGGAGAA-------------------------------- -----AAGGGAACACTTAT-ACACTGTTGG--TGGGAA---------------------- -------------TGTA-------------AATTA-GTTCAGCC--------ACTATGG- -------AAAACA-GTTTGGAG--ATTT-CTCAAAGAACTAAAA--ATAGAACTACCA-- -TTTGA--CCCAGCAATCCCATTACTGGG-TATCTA-CCCAAAGG-AAA--ATAA----- -------------------ATCATTCT-ACCAA--AAAGACACCTG----------C--- ---------ACTCA--TATGTTTATCACAGCACTATT---CACAATA-GCAAAGACAT-G GA--ATCA--ACCTAGG-TGCCCATCA---ATGGTGG-----ATTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTACATAT----ACACCATGGAATAC--TACACA-GCC ATAAAA----------------------AAGAATGAAATCATGTCCTTT----------- ------------------------------------------------------------ -GCAGCAACATGGATGCAG-C---T----------------GGAGGCCATTATCCTAAGT GA-------------------------------------------------------ATT A----------------------------------------------------------- ----------ACGCA--GAAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAA---- -----------------------------CCAAATAC-CACATG--------TTC----- ------TCACT---TAT------------------------AAGTGGGAGC---CTAACA T----------------------TGGGTA---------------C--------------- ------------------------------------ACATG-------------GACA-- -------TA------------------------------------------AAGATG--- -GGAACAATAGA---CACTG-----GGGACTCCA---------AAAGGG----------- -GGGAGGGAGGG------------------------------------------------ --AGG-------GGGGCA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGG----------GTTG--AAAAACTT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CCTATTG---------------------------------------------- --------GGTA----CTATGTTC----------------------ACTATTTGGGT--G ATGGGA--------------------------------------TCAATAGA-------A GCC-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCTCAGCA-- -------------------TCATGCAATATA--------C-------------CCATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA------------------------------------------------------- ------AACC-TGCACA-------------------------------TGTACC------ ------------------------------------------------------------ -------------------------------------------------CCC-------- -------------TGAATC------------TAAAATA----AAAATGAAA------AT- -------AAAAAAA---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1PB4 -----------------------------AAGCAGCTTTATG--GATGATT-GGTAGCGA CAGACAGCTGC---CTCCTCCT--------CAAAGAAGAAAA------------------ ---------------------AAAT---------TAGCAGGTAAATAAT--------CAC AT--TTTGAATA--A-----ACTTTTGAGAGAAGAGTGCGGGAG-----------CCAAC AAGA---GAGCTCCCAGGAAAAACTGGGGGTAGGA------------------------- ----------------------AAGAAGAAGAAGGGGAGCCTGTTG-------------- --------------------------------------GAGAGCAGCGACCGGGAATTG- -------------AGGA---ACCTGGTTTT----CTATG----------------GAAAA GGGTGGGGGG---------------------------GGGTTTC-TTGGTTCCCCACGTC C-------------------------CTGTGGCAGACTGCTGGTTTCCGA----GCTATT GGAGAGCTCCTCTGCCCT---CAC------------------------------------ ---A---------GGCCTAAAGACTGGTGTGG------------------GTAGCGATTG GGAGCTTGTTTGAGGGCACTG-------------------CTTGTACTTGCAGGCTGTCC AAGGCTATCTCGCCCTCCCCCCATACCCAGACTGGAGTGGCAGGC--------------- -------------------ACAATACTGAGGTTGCATCCATTGGGGGCCTAAGTCCTGCC CGGGAAATCTAAG------------CCCTGATGTTTCAAAATACCCGATTCCTCGTAAAC ATTCCCCAGCATCT-ACTCAGACTGCGGCAGCCACAAAGGGCTGGCAGGATCCAAGGGAG CTGCAGGATTCCTGGTGGTCTAACCCTCAAGGCATGCTGCTCTTGGGGAAAGGGAGTAAA CATTGACAGAATTGAAGGGATAAATACATATCAACACAGTAATAGTAGGAGATTTCAATA GC-----------------CCACTTTCAATAATGGATAGGACCACCAGATATAAGATAAG ATCAATAAAGAAATAAAGGACTTCTCTTTTTT--------TTCCCCCAAGGCGGCAGATC AGAGACTC---------------------------------TTTTAGCATGCTTCACCTA TTCAGAATCAAAAAAAAAAAAAAACAG----------------AAACAGAAACAAAATAG TAAAAAATTACACAGGGTTCTGCAGCCTGCCATGA------GGCGGGTACTGCCAGATGT CA-------------GAACAGGGAGGGTGAGAAGGGGCAAGGTATTTACGCAAACCGACG ACAACTGCCGCTGTCTTCTCCGCCATGGGCTGCGGGAAGAAGGTGCACT----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CTGACGATGTCCTGCGTGCCTGC------------GAACCTCTACCACA GGTGCCTAGTGGCACGTTCCAAGCGAATGCGCCTAGCGTTGCTGGTGGGAGAAAAACAGA GCGGACGTTCTTGCGTTCAGGGGGTTTCCTCCGTTGGTCCTGTGGTGGGTTTGCCCCCCT CCTGCATGGCTATGGTTTTCG---CGCGGGGGTCTTGAGGGGAGGTTCGCGGTTCTGGTT CCGCGCCGCGGTGGCTCTGGCGCCCCGCCCTGGGATGGGAGTGGGGGATTTCTCCTCCGC CCGCCGGGGGGGGGGGCGCCCCCATTGGCCGTGCTGGGAGGAGGGTGGGGGGTGGGCTTG CTGGGTGGATTGGGAGGCTGGGCCCCCCCCCCTTCTGTGGGCCGGACTGGTCGGGGCTTG GCCTGGGGT------CCCGGTT--TCTCCCCCTGGGAGCGCGGGGCCTCAGC-------- ---------GGGGCCGGGATGGG--------------GAGTTGGGGAGCTGCGGTTCTCC CTT---------------------------------TGTCCTGCTGTGGGAAGTATGGGT GGCC------GGGGGCCGTCGGCGCTGCTCCCCCG---------------------GGGG GCGCGGGCTGC---ATAGCCGTC----GGTCACTCCACCCTTT---------------GT TGGTGGGCGT--GTGTCCCTCTCTCACCGGGGGGCGGGTTCTGGCGCCGGAGGGATGTGG TCCCTACCTGCC-------------------------TAGTCGTTTTGCTTCCCCGGGCT GGGGGGTTCTTGCGTTCTCCTTGGGCTTTGTGTTGGTCTGTG------------------ ------CGCACCGCAAGGCTGGAGCCAGCTCCCCCCCCCACAGGGGTGGTGGTTGCTCCG GTCGTGACGGGCTGCGGGCTGGGCGCGTGGCCCGGTCCGCCCCCCTCTCCCTTTTCCCCC CCTCCGGGGCTGAGTAGGGAGCTCAGGC---------------------------CACTG GGCATT------------------------------------CCATAGCCCAGCCCATTG CCTGAGGCA----------ACAGAGAGCTTCTC--------CTGGTAAACA--------- ------------AAGATCAAGCA------------------------TATACCCATCTGC TTCCG-------------CCGCA---------GCTG------------------------ -------------------------------------------GCTCTTACCTGCAAGCA C---CACCTACTGGCCTGGAGGTTG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ AACTGCACAACCCAATAAAAATCCTGCTGACACAAGTGCACAGCGCTGGGGAATGAGATA AGCTTCCTGAGACCTCCACCCCCCCATCCCTGCAACCGCAGCCCCACAGGAGGCAGTGAG CCTGCTCACATGCCCAGTACATCGCTACTACAACCAGCATTTGAGAAAGCCACCACACTA AGGCTATCTATTAACCAAGGAATTCATACAGAGCCTTGGCCACTTGAAAGCACCCA---- ------------------------------------------------------------ --------------------GAACCAA------------------------------AGC C-----------AAATGACCCTACACAACATACATT------------------------ ------------------------------------------------------------ -----ACAGTCACATCCTCAAGGGGAA--------------------------------- ------------------------------------------------------------ -----------AAAAATCC----------------------CAT---------------- -----------CCAAATGAAAGT------------------------------------- --AAATTCAA-AAATAAGA----------------------------------------- ---AGTGATAGCTTCT-------------------------------------------- ------------------------CCAGATGATAAGATGAGAAG---------------- ------GAACCAGT-------GTAAGAATTCT-------GGAAATATGAAAAAACAGGGT GTTATAACACCTC-----CAA------------AGGATCACACTAATTCT---------- CCAG---CAATAGATCCTA-------ATC-------AAAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGA-AATGCTCA AAAT------GCCAGTTA------AAGAA------------TTCAAAAT---ACTAAT-T ATAAGGA---AGCTCAATGAGAT----TCAAGAGAAAG---------------------- ------------------------------TTGAAAACCAACAC---AAAGAAAT----- ----------------------------------------C------------------- ----AGAAAAACAATTCAAGATATA---AATAAGAAATT--------------------- ----------------------CACTA-------------AAGA------GATAAAAA-- --------------------------------------TTAAAAAA-------------- -----AAAACAGAAC--------------------------------------------- ------------------------TTCT-GGAAA---TGAAA---------AATTC---- -ACTGAAGGAA----TTACAAAATACAGTTG-------AAAG------------------ --------------------------------------------CTTTAACAATAGACT- -----AGACC--AAGC------------------AGAAG---------AAAG-AAT-TTC AGAGCTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACAGGTCTTTTGAAT-T--AACCCAG------TCAG---------ACAA--- ------------------------AAAAAAA---AAA---ATATTAAAAAA--------- TAA-AAAAAGCCTTTAA--GAAATATGGG-ATTATGTA-----------AAGCG--ACCA AACCTATGAG-TTATAGG--CATTCCTGAGG-----------------GAGAAGAAAAAG TAAAAAGTTTGG---------AAAACCTATTTGA--G--------GGAATAATTCA-G-G AAAACTTCCCTGGTCT--------------------TGCTAGAGATTTAG--ACATCCAG ATAC-----AAGAAGCTCAGAGAAC---ACCTGG-AAGAT--------ACT--------- ---T-TGCAAGAA-----GAACCTCACCAA----------------------------GG CATATAGTCATCAGACT------ATC-CAAAG---------TCAATGTGA---------- ------------AGG--AAAAAATCC---------------------------------- --------TAAAAGCAGCAAGAGA---GAAGCATC--------------TAATCAC---C TAT----------AAAG--------------GAAATCCCAT--CAGACTAA-C--AGCAG ACT--------TCTCAGCAGAA--ACCTTA-CAAA--CCAG-AAAAGAATG--------- ----GGG-GGCTATT-T-------TTAACT--T-TCT-TAAAAAAAAA------------ -AAA-TG--CCA--GCCAAGAA--------TTTTAT----------ATCCT--------- --GCTAAACTAAGC-----TTCA-TAAATGA-------AGG-AGAAATAAAGTCTTTCCC AGACAAGC-AAATGCTAAGGGA-ATTTATCACCACTAGAC---CAGTCCTAC-AAGAAAT GCT--------------CAAAGG----------------------AGTTC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATGG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AATGACA----- --------------------GGAACAA--AACC-TCATATATCAATAT------------ -------------TAAC-CTTGAATG-TAAATGGATT--AAATGC---TCCACTTAAAAG ATATAGAT--TGGCAGAA-TGGAT------------------TAAAAAACCAACCA---- ---TAT-GCTGCTTACAAGAA-ACCCACCT-AACTG--GTAAAGACACTTACAGACTCAA AG--TAAAGGGG--TGGAAAA-AAATATTCCATGCAAAAAG------GAAAC-------- -------------AAAAAATGAGC-G--GAGTAGCTATACTTATATC-AGATAAAACAGA CTTTAAA-TC----------AACAACAGTAAAAAAA----AAAA-AAGGTCATTATAT-- ----AATGATAAA---GGGATCAATTCAAC--AAGAAG--------AT-ATAACAATCCT AA-----------------ATATATATGCACCCAACACTAGAGCACCCAG--ATTCATAA AACAAATACTACTAGACCTAAAAAAAGAGATAGACAGCAATAC---------AATAATAG TGGGGGACTTCAACACCCCAC-----TGACAGCACTAGACAGA----------------- ----TCATTGAGAC------AGAA--------AAACAAAGAAACACTGGACTTA------ --AATTGGACTCTAGACCAAATGGAC-CTAACAG--ACATTTACAGAA--CATTCTACCC AACAACTG---CAGAATATACATTCTTCTCA-------TCTGCACAT---GGAACATTCT C------CAAAATAGACCATATGTTAGGCCACAAAGCAAG-------------------- -TCTCAATAAATTTTTAAAAA--TCAAAAT----------------CATATCAA------ -GTATCTTCTCA---GACCACAGTGGAA-TAAAACTAGAAATCAATACCA--------AG A-------------GG-AACTCTC---AAAACTATACAA----ATACATGGAAATTAAAC AACATG-CTCCTGAA---TG-ATCTTTG--GGTCA---ATGATGAAAT--TAA-GACAGA AATTAAAAAAATTTTT---GAAAT------------------------AAATGAAAATAG -AGACACAAC--ATACCAAAACCTC-TGG-GATACAGCAAAAGCAGTGCTAAGAGGGAAG --TTTATAGCATTAAATGCCTACATCAAAAAGA---TAGA--AAGATCT---CAAATTAA ------CAACCTAATGTTACACCTCAA---GGAACTAGAAAA---AC---AAGAACAAAC CAAACCCA-AAGCTAGCA------------GAAGAAAAGAAATAAC-AAAGATCAGAGCA GAACTA---AATGAAATTGAGACCAAAAAAA-AAA---TACAAAGGATC-AATGAAATAA -AAAGT-------TGGTTCTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGATAGACTA---CTAGCTA------GATT-------------- AACCAAGAAAAGA---------GAGA-AGATTCAAATAAG-------------------- -----CACAA---T---------CAGAAATGAAAAA------GGTGA---CATTACAACT G--------ATAC-CACAGAAATA-CAAAAGATC--ATCAG---------AGACT----- -------------------ACTATGAACAT-CTCTATGCTCACAA--AC---TAGAAAAC CTAG---AGGAAAT--GGATAAATTCCT--G---GAAACA---------TAC-----AAC CTCCCA------AGATTGAACCAGGAAGAAATAGAAATCCTGAAC--------------- --------AGACCA------A------TAATGAGTAGTGAAAT----TGAAT--CAGTAA -TAAAAAATCTCCCAACAAAAAAAAG--CC-CAGGACC--AGATGGATTCACAGCCAAA- TTCTA------------CCAGACATAC----AAAGAAGAACTGGTA-CCAATC-----C- ----TACTGAAACTATTCCAA-------AAAATTG-AGGAGGAGGG-----------AAT CCTCCCTAACTCATTCTATGAA---------GCCAGTAT---CACCCTGATACC--AAAG C-----------------------CAGGC--AAGGACA-CAAC----AA---------AA AAAGAAAACT---------------------ACA------GACCAATAT--CCC----TG ATGAACATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACCA------------------AA--T------------ ---C-CA--ACA-------------GCACATC---------AAAAAGATAATACA--CCA ----TGAT------------CAAGTGGGT-TTTATTCCAGGGA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATAC----AAATCAATAAATGTG--ATT CACCAC---------A------TAAACAG----AATTAAAAACAAAAAC---CATATGA- ----TCATCTC---AATA----------GATGCAGA-AAAAG---CATTTGATAA---AA TTCAGCATCCCTT-------------------CATGA---------T-AAAAAC-CCTCA --ACAAACTAGGCATAGAAGGAACAT-----ACCTCAAAATAAT---------------- -----------AAAAGCCAT-ATAT-GACAAACCCACAGC-----------CAACAT--C ATACTGAATGGGGAAAA-G-----TTGAAAGC-ATTC---CCCCTAAGAA----CTGGAA CAAGACAAGGATGC-------CCACTTT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATCAG------GCAAGAG---AAAGA--AATAAAAGGC ATCCAAATTGGAAA-------AGAGGAAGTCAAA--TTATCTCTG-----TTCACTGATG AT--ATGATCTTA-------TACCTAGAAAACCCT---------------AAAGA---CT CCTCCA---------AAA--GACTCCTAGATTT---------GATAAA--TGACTTCAGT AAAG--TT-------------------------TCAGGATACAA--------------AA TCAATGT------------ACAAAAAT----CAGTAGCATTTC--TA-TACACCAA--TA ATGATCAAGCTGA------------------GAACCAAA-TCAAG----AACTCAATCCC ATTTACAATAGC-TACAAA---AAAAATAAA------AGGAATACATTT--------AAC -CAAGGAGGTGAAAGATCTCT---ACAAGGAG--AACTACAAAACACTGATG-AAAGAAA TCATAGA-----------TG------------------ACAC--AAAC--AAATGGAAAA ACAT------C---CCATGCTCATG------GATTGGAAGAATC-----AATA-TTGTT- ------------------------AAAATGACCA-TA-CTGCCC-AA------------- ----AGCAATCTACAGA---TTCAATGCAATTCCTATCAAATT---------ACCAATA- TC------------ATTTTT---------------------------------------- --CACAGAATTAG---AAA------AAAAAATCCTAAAA-TTTATATGGAA-------CC AAAAAAGAGCCC---AA--ATAGCCAAAGCAATCCTAAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACA---TTACCTGACTTCAAATT-----ATACTACAA---GGCT ATAGT-AACCAAAAC-AG------CATGGTACTGG--TA-----------------TAAA AATAGACA------CATAGAT--CAATGGAACAGAATAGAGAACCC------AG--AAAT AAA---GCCACATACCTACA----ACCAAC--TGATCTTT---GACAAA--GTTAA--CA AAAACATAC--AATGG-----GGAAAGG----ACACC--------CTATT--CAATAAAT GGTGCTG----------G-GAAAAT--TGG-A-TAGCCA---------------TATGC- AGA---------AGA--ATGAAACTGGACCCCT----ATCT---------------CTCA CC--ATATACAAAAA-TTAACT-CAAGATGGATTAAAGACTTAAATGTA--AGACCTGAA ACT-AT------------------------AAAAATCCTAGAA----------------- ------GAAA--ACCTA------G---------GAA---------AAACTCTTCTGGAC- --ATT-----GG-CCTAGGCAAAGAATTTATGACTAA-GACCTCA-AAA----GCAAATG CAACAAAAACAAA----A------AT---AGAC--AAA-TGGGACTTA--AT-------- -------------------------------------------------------T-AAA CTAAAAAGCTT-CTGCA---CAGC-AAAAGAAA---TCAAC-AAAG-TGAACAG-ACAAC CTAC--AGAA--T-GGGAG--AAAATATTT---GCAAACTATGCAT--------CTAACA AAGGACTAA-------TATCCAGAATCTACA--AGGAA--CTCAA-----ACAAC----- ----------------------TCAACAAGAA------AAAA------------------ AAAAACCCCA-TTAAAA----------AGTGGGCAAA-----------GGA--CATGAAC ---AGACATTTTTCAAAAGAAGACATACAAA--------------TGGCCAAC-AAACAT ATGAAAAAATG----CTCAACATCACTAA-TCATCAGAGA-AAT--GCAAATT-AAAACC ACAATGAGA---------------------TACCATCTTACACCAGTCAGAATGGCTA-- ----TTATTAAAA---AGTCAAAAA-----------ACAACAA--ATG--TTGGC-A--- ---------------AGAAGGGGAGAAA-------------------------------- -----AAGGAAATACTTAT-ACACTGTTGG--TGGGAA---------------------- -------------TGTA-------------AATTA-GTACAACC--------TCTATGG- -------AAAACA-GTATGGAA--ATTT-CTCAAAGAACTAAAA--ATAGAACTACCA-- -TTTGA--TCCAGCAATCCCACTACTGGG-TATCTA-CCCAAAGG-AAA--AGAA----- -------------------ATCATTAT-ATCAA--AAAGATACCTG----------C--- ---------ACTCG--TATGTTTATCACAGCACTATT---CACAATA-GCAAAGATAT-G GA--ATCA--ACCTAAG-TGTCCATCA---ATGGATG-----ATTGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTATATAT----ATAC------ATAC--TATGCA-GTC ATAAAA----------------------AAGAATAAAATCATGTCTTTT----------- ------------------------------------------------------------ -GCAGCAACATGGATGGAA-C---T----------------GGAGGCCATTATCCTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------ACTCA--GAAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAATCAA ATACCACATGTTCTCACTTATAAGTGGGGTCAAATAC-CGCATG--------TTC----- ------TCACT---TAT------------------------AAGTGGGAG----CTAAAT A-------A--------------TGTGTA---------------C--------------- ------------------------------------ACATA-------------GACA-- -------TA------------------------------------------CAGAGT--- -GGAATAATAGA---CACTG-----GAGACTCC----------GAAAGG----------- TGGGAGGGTGGG------------------------------------------------ --AGG-------GGGGTG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGG------------GATGAGAAATTA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CCTATTG---------------------------------------------- --------GGTA----CAATGTAC----------------------ACTATTCGGGT--G ATGGGT--------------------------------------ACACTAAA-------A GCC-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GACTTCACCA-- -------------------CTATGCAATATA--------T-------------CCATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAACA-----AAAC---------------------------------------------- -----------TGCACT-------------------------------TGTACC------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------CC------------CTAAATC----TATAAAAAT------AA- -------AA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MB7 ---------------------------AGGTGGAGCAAGAT---GGTGAAT-AGAAGC-- CCACACTATTC---ATCCCCCA--------ACAAGAACACCAAATGTTAACAAGTATCTT CACGCAGAAAAGCACCATCACAAAAACAAAAAATCAGATGAGCAATCAC--------TGT AC--TT--------------GGTTTTCACTTCATATCACTAGAA-----------GAGGC ATTA---AAGATGGTAGGAAAGACCATCGTGA-----------------ATCACCAACAC CACCTGTCTCCATCTTCCAGTAGTGGCTACTCAGTGGAGAGAGTCA-------------- --------------------------------------GTCTGTGTATGCAGAGGACAGA GAGCGCAGCAAATGGGG---GACTTTACATAGAACTCAGTGCTGCCC-----TGTCACAG AGGAGAGCAAAGCCATGTTGGG-----------------------CTCGGGCAGCACCCA C------------------------ATACAGAGGGAGCATGTGGACCAGACTTAGCCAGA GGGGAATTGCCTATCCCAGTGGTT------------------------------------ ------------GGAACTTGAGTCCCTTAGTAAGCCATGCCATTGCAGGTCAAAGTGCTC TGGGGTACTATGTAAACTTGA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------AAGACAGTCTAGGCCGGAGGGACTG TAATTCCTAGGCGACTTCTAGTGC------------------------------------ ---CTGCCTGGACTTAGAGCCTGGGGACCAGGGTGAAACATGACTATGGAGACAC----- ------------------------------------TAGTTGGG---------------- -------------------TTAGCTAAGGGAGAGCTTGTGCCACCCCTCCTCCAACTCCA GGCAGTGTGACTCACAGCAACGAAA---------------GTGACTCCTTTCTTCTG--- -----------------------------------------CTTAAGGAGAG-------- -----------GACATTGAAGTGTAAAGA--------------GGATTATGTCTTG---- ---------------TATCTTGGATACCAGCTCAA---------------TCGCAGTAGC ATAGAAAATCAAGTAGACTCATGAAGCCC------------------------------- ----------------------------CCATTCCAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GTCCCAGCTCCCAAACAACATTTCTAAACACAGCCTGGGCC AGAAGAGAACC-------------CACTGCCCTGAATGGAAGAACCCGGTCCTGACAGGA TTAATCACCTGCTGACTAAGGAGCCCTTGGGCCCTGAATAACTAGCAGTGATACTCAGAT AGCATGTCATAGGCCTTGGGCTCTCATACATGGTCA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ CTACGGGTATGACCTAGC------------------------------------------ -----ACAT------TTCTGCCCATGGTGGCTGTGGTGAAAGACTCTTTCCATTTGA--- ---------GAAGAGCAGAAGGA--------------AATGTAAAGGGGTCTTTGTCTTA CA-----------------------CCTTAGGTACCAGCTCAGCCACAGTAAGGTAGAGC AGCAACA-----AGAAGGTGCTTGGGGTCCCTGAGTTCAAGCCTGAGCC-------ATTA GACAGAAATTTTGGATGTTCCCTGGGTAGAGGAGAGCCCCTT----------------GC TCTAAACTATGAGTTCCAGGCCTGGCAGCAATCACGAGCAAATCATAAGCTGACTAAAGA GCCTTAGGGCTTTAAGTGAACATTTGTTGTAGCCTGGCAGAACCCTTCTTCAAAGGAAAA AGGAATCAGCAGAAATGATCATTATTTGACATGACTCAAATA------------------ ------TTACTGAATAGAAAAAAACTTTTT------------------------------ ----------------------------------------------CCAATGGGCATTTA TTGAAAAAAATTAGAAACAATTAC-------------------------------TAAAC ATCATGGATATACCAAATAGTAGAAAA---------------CTGTTGGGCAACCAATGA GAAAACAACCGAACTTAAAACTAAAAGGTGAGGGGAAAATATCCACAAGGA--------- --------------GATTTTGAA-------------------AACTATAAAATATTTCTA GAAAA-------------CTACA------------------------------------- ------------------------------------------------TGCATAGGATTG TATGTACACTCAAGACTATGTGCATGCTAAGA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AAAGACATAAAAAGGCCCTGAGCTCTCAATCCTGACAAAC CTTGAGATTCTGAACAAACAGGAAGTGAAGATTAAAGAAGAAATGTAAAATGTCTGACTA AGTGTTGAAGACATGCACAGACATCAACAGTAAGTTACATAGCAAACGCTATGAGACAAA TTAAAAAAAAAATAATAAGAAACTTTGTTTAATAATTAGAAGACCACTTTGGTATCTAAT C----------------------------------------------------------- -----------AAAGACCTCTATGGCGGTACCTTAACAAGCCAT---------------- ----AAAAATTACAAATAACATCAAGAAGAAAATAAAAG--------------------- --AACAACAATAAATCCAGAAATAGGTTTTGAGGATGATGATCAAAAATACGACAGTAT- ---GTATGTAACATTACAACT--------------------------------------- -----------------------ACTCAACTATCCAGTTTCAAG---------------- ------ATATTAAA-------AAAAACATAAA-------GAAAATAATATAAACAGGAAA TATA--------------CAA------------ACTAATAGAATAGATCAGAGTGGAAGC TCAG---AAATGGATCTTA----------------AAGAC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TAGGACTTAAAG AATCTCT---GATAAATAAGTGAAAAGAA------------CTAAAAAG-----AGATAA ATAAAAA---TATTTTAAGAAAA----CAAAGAGAATA-------------------AAA GAATATTTTTTCATGAAATATTAACTATAATAAAAAAACAATAA---AAAGAAACAAAAC ACAAATACTAGAGCTGAAGATCATAAGGACTAGGCCAGAATTTTCAACAGAATTCCTTAA TAGCAGAAAAAATCATGCAGAAAGA-----AGAAAGATC--------------------- ----------------------GCCAT-------------TGAA------TATAAGCCAT TTGCAACTACCTAG------------------------TCAAAAGAGAAAAAAAAATAAA AAAAAAAGAAAAAACACCAGAAACATCAAA------------------------------ ------------------------TTCT-GGATT---TGAAA---------TATAC---- -AATAATTGAA----ATTAAAACTTCACTAG-------AGGG------------------ --------------------------------------------GCTCAACAGCAGATT- -----TGAAA--TAGC------------------AGAAG---------AAAG-AAT-TAG CAAACTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGATAGGTCAATAGAGA-T--TATCCAA------TCTG---------AAGA--- ------------------GCAGAAAGAAAAA---AGA---ATGAAGAAAAA--------- TGA-ACAGAGCCTCAGA--GACCTGTGGG-AAACCATC-----------AAGTA--TACC AACATATTCA-TAATGAG--AATCCCAGAAG-----------------GAGAGGAGAGAA AAAAAGGGAAGG---------AAAGAATATTTGA--A--------GAAATAATGGC-C-G AAAATTTCCCAAATTT--------------------GATGAAAAACATTA--ATCTACAC ATTT-------------CAAAGAA----GATACA-TGAAT--------TCA--------- ---T-AACAAAGA-----GATCCACACCTA----------------------------GA CACATCATAATCCAATT------GTC-AAAAG--------------ACAA---------- ------------AGA--AAAAATTTT---------------------------------- --------TAAAAGCGGCAAAAGA---AAAAGAAC---------------TATTAC---T TAC----------AAAG--------------AATCATTAAT--AAAATTAA-C--AGTTG ATT--------TCTCATCAGAA--ACCATG-GAGG--CCAG-AAGGCAGTG--------- ----GGA-TGACATA-T-------TCAAAG--T-GCT-GAAAGAAAAA------------ -AAA-AA--TCA--ACCAAGAA--------TTCTAT----------ATCCA--------- --GCAAAACTATCC-----TTCA-AAAATGA-------AGG-AGAAATTAAGACATTCCC AGATAAAC-AAAAACTGAGAGA-ATTTGTTGCTAGAAGAC---CTGCCTTAC-AAGAAAT ACT--------------AAAGGG----------------------AGTTT---------- ------------------------------------------------------------ ----------------------------------------TTCAGGCTGAAGGAAAAGGC GGATAGTATGTCCAAATTAAAGAAGTACAAAAGCTAAAACTGAAAACAAAATAAATAGTA TTCCTAATCATCAAAATTTAAAAATGAATGATTAAAAGACAACCAAAAATAACAAATAGT AT---------TAAACTTCATCAGATCGGAATAAAAAGACATAGGAAAAGTAATTGAGGA GGCTGGAATGAAAAAACATTAACTGT-----------------AAAGGGGA--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ACAAAATTACAAGGTAAAAGA ACCCTTGAAATAGTAAATAGAAAGTAAATTATAAAAGTCTAAATATTTTTTTTTATTTTC TTTCTACTCTTATCTAAAAAATAAAGGACAACAGAATAAAAATAATTGAAAGATTATTGT CTTAACTTTTTAAAACGTGTAATTTGTGTGAAAAAACAGACAAAGAAAGGGTGGGGAGAT GAGA-------------------------------------------------------- -----------------------------------------------TTTTATTGAACAA AGTTTTTGTATACTGTTGAAATTAAGTTGGTATTAACTTGAACTAG-------------- ----------------------------------ATTG---------------------- --------------------------------------------------TTTTAAGTTA AGGTGATTATTACATCCCCTGGAAAACCCATGAAA-----------AAATCAAAGCAAAA TAATAAAAAAAAAGAAAAATAAT----------------------AAACTATAAGATAAA ----AA--------ATCCAAACTAAACAAAAG------AGAAATTAGTTG--ATAAAAAA AAGAAGAAAAAAAGAAGAAAA--------------------------------------- ------------------------------------------------------------ ----------------------------------ATATATAACAAAAAAAT--------- -------------TTAT-AATAAATATTAAATGGATA--AAAT-----CTCCATTAAAAG ACAAAGAT--ATATAAAAAATGAT-ATTGGAAGGTAAAAAATACATGATCTAACTA---- ---TAT-GCTGTCTACAAGAG-ACACACTT-TAGAT--TTAAAGACACAAATAGGTTGAA AG--TAAAAGGA--TGGAAAA-AAATATACCATGCAAATAG------TAACC-------- -------------AAAAG---AGAAGGAGAGTGTGTATACTAATAAT-AGACAAAATAGA CTTTAAG-AA----------AAAAATTTTTACAAGAAAA-AAAG-AAGTATATTATAT-- ----AATGATAAA---AGGGTCAATCCATC--AAGAAG--------AT-ATAACAATTAT AA-----------------ACATATATGTACCTAACAACAGAGCCCCAAA--ATATATGA AAAAAAAAATGACAGAATTAAAGGAAGAAATAGACAATTAAAA---------AATAATAG TTGGAGACTTCAATACTTCAC-----TATCAATAATAGATAGA----------------- ----ACAACTAGAC------AAAA-----GATCAACAAGGAAAT-----AATTG------ --AACAACACTATAAACCAACTAGAC-CTAACAG--ATATCTATAGAA--CACTCCACCC AACA---------------------TTTTCA-------ACTGCACATATAGGAACATTCT C-------AGGATAGAACATATATTAGGCCATAAAACAAG-------------------- -TCTCAATAAATTTAAAAAGA--TTGAAAT----------------CATACAAA------ -ATATGTTCTCT---AATCACAATGGAA-TGAAATTAGAAATCAATAACA--------GA A-------------GGAAAATTTG---GAAATTTAAAAA----AAATTTGAAAATTAAAA AAAAAA-TTCTAAAA---AACAACAAAG--GGTAA---AAAAAGAAAT--TAA-AAGGGA AATTAGAAAATACTTT---GAGAT------------------------AAATGAAAATAA -AAACACAAC--ATACCAAAATTTA-TGG-GATGCAGCTAAAGCAGTGCTTAGAGGGAAA --TTTATAGCTGTAAATGCCTACATTAAAAA-----AAAA--AAAATCT---CAAATCAA ------TAACCTAACCTTCCACCTTAA---GAAACTAGAAA---------AAGAAAAAAA AATACCCA-AAACAAGCA------------GAAAGAAGGAAATAAT-AAAGATTAGAAGA GAAATA---AATGAAATAGAGAATAGAAAAG----------AAAAAATA-AAAAAAACAA -AAAGT-------TGTTTTTTTGAAAAGATCAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGACAAACCT---TTAGCTA------GATT-------------- GACCAAGAAAAAAAG---A---GAAA-AAATTCAAATTAC-------------------- -----TAAAA---T---------CAGGAATGAAAGA------GGGGA---CATTACTACT A--------ACCT-TACAGAAATA-AAAAGAATT--ATAAA---------GGAAT----- -------------------ACTATAAACAA-TTGTATGCCAACAA--AT---TAGATAAC CTAG---ATGAAAT--GGACAAATTCCT--A---GAAAGA---------CAC-----AAA CTACCA------AAACTGACTCAAGAAGAAATAGAAAATCTGAAT--------------- --------AGACCT------A------TAACAAATAAAGAAAT----TGAAT--TAGTAA -ATAAAAAACTTCCCACAAAGAAAAC--CC-TAGGCCT--GGATGGCTTCACTGGTGAA- TTCTA------------CCAAATATTT----AAAGAAGAATTAAAA-CCAATC-----C- ----TTCACAAACTCTTCCAA-------AAAATAG-AAAAGAAAAG-----------AAC ACTTTCCAACTCATTCTATGAG---------GCCAGTAT---TACC---ATACC--AAAA C-----------------------AAGAC--AAAAAAA-TAAC----AA---------AA AAAGAAAACT---------------------ATA------GACCAATAT--CCC----TT ATGAATATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAAC-AAAACA------------------AA--T------------ ---C-CA--ACA-------------ACATATA---------AAAAGGATTATATA--CCA ----TGAC------------CAAGTGGGA-TTTATCTCAGAGA-TATAAG---------- -------------AGTTGTTT-AAC-----ATTAAA----AAATCAATAAATGTA--ATA CACCAT---------A------TTAATAG----AATAAAGGACAAAAAC---CACATGA- ----TCATCTC---AATA----------GATGCAGA-AAAAA---CATTTGACAA---AA TCCAACACCCTTT-------------------CATGA---------T-AAAAAC-ACTCA --ACAAACTAGGAATAGAAGGGAACT-----TCCTCAACCTGAT---------------- -----------AAAGGACAT-CTAT-GAAAAACCCACAGC-----------TAACAT--C ATACTTAATGGTGAAAG-A-----CTGAAAGC-TTTT---CTCCTAAGAT----TAGGAA CAAGACAAAGATAT-------CCATTTT-------------------------------- ------------------------------------------------------------ ------------------------TACCACTTCTATTCAA-CATT--GTACT---GGAGG TTCTAGCCAG--------GGCAATTAG------GCAAGAA---AAAGA--AATAAAAGGC ATCCAGATTGGAAA-------GGAAGAAGTAAAA--CTATCTCTA-----TTTGCAGATG AC--ATGATCTTA-------TATATAGAAAATCCTGAAAAA---------AAAAA----- ---------------AAAAAAAATATTAAAGCT---------AATAAA--TAAATTCAGC AAGG--TT-------------------------AAAGAATACAA--------------AA TCAATAT------------AAAAAAA-----CATTTGTATTTC--TA-TACACTAG--CA ATGAATAATCCAA------------------AAATGAAATTTA------GAAAAATTTCT ATTTACAATAGC-ATTAAA---AAGAATAAAATAAAAAGAAAT----TT--------AAC -AAAAGAAGTGAAAGACTTGT---ACACTGAA--AACTACAAAACATTGTTG-AAAGAAA TTAAAGA-----------AG------------------ACCT--AAAT--AAATGGAAAA ACAT----------CCATGTTCATA------GAATTAAAAAATT-----AATT-TTTTT- ------------------------AAGAAGGGAAATA-TTTCCC-AA------------- ----ATTGATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------CCCAGCT- TG------------CTTTTT---------------------------------------- --TGCAGAAATTG---ACA------AGCTGATCCTAAAA-TTCATATGGAA-------AT GCAAGGGACCCA---GA--ATAGCCAAAACAATTTTGAAAAAGAAGAACA---AAGT--T -------GGAGGACTCACA---CTTCCCAATTTCAAAAT-----TTACTACAA---AGCT ACAGT-AATCAAGAC-AG------TGTGGTACTGG--CA--------------------T AAGAGACA------AATAGAT--CAATATAATAGAATTAAAAATCC------AA--AAAT AAA---ACCATAAATTTATG----GTCAAA--TTAATTTT---AACAAAAGGGTC---CA AAGACAATT-TAATGA-----GGAAAGA----ATAGT--------CTTTT--CAAAAAAT GGTGCTGATATCCACATGCAAAAAA---------ATCAA---------------CACGC- AAA---------AAA--ATAAATTTGGACCTTC----ACCT---------------CAAA CC--AAAAACAAAAAATTAATC-AAAAATGGATCATAGACCTAAATGTA--AGAGCTAAA ATT-AT------------------------AAAACTCTTAGAA----------------- ------GAAA--ACATA------G---------GAA---------TAAATCTTTGTGAC- --CTT-----GG-ATTAGGCAATGGTTTCTTAGATAT-GACACCA-AAA----GCACAAG AAACAAAAAAAAA----A------AT---AGAT--AAA-TTGGACTTC--AT-------- -------------------------------------------------------CAAAA TTAAAAATTTTTTTGTT-----TC-AAAAAACACCAATAAAAAAAA-GAAAAAA-AAAAC CTAA--AAAA--T-GAGAGAAAAAATATTT---ACAAATCATATAT--------CTGATA AAGGTCTAG-------TATCCAGAATATATA--AAGAATTCTT-------ACAAC----- ----------------------TCAATAATAA------AAGGGA------------T--- AAAGATT----TGAAAA----------AAAGGCCAAA-----------AGT--TTTAAAT GGAAGACATTTCTCCAAAGAAGATATACAAA--------------TGGCCAAT-AAGCAC ATGAAAAGATG----CTCAACATCATTAG-TCATTAGGGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TACCACTTCACACCCACTAGGATGGCTA-- ----TAATAAAAA---AAACA---------------ATAATAA--ATG--TTAGT-A--- ---------------AAAATGTGGAGAA-------------------------------- -----ATTGAAACCCTCAT-ACATTGCTGG--TGGAAA---------------------- -------------TGTA-------------AAATG-GTATAACT--------TTTTGGG- -------AAAACA-GTTTGGTA--GTTTCCTAAAAATGTTAAAC--ATAAAGTTACCA-- -TATGA--CCCAGCAATTCCACTCCTAGG-TATATA-CCCAAGAG--------------- -------------------AATATGTT---CAC--ACAAAAACTTG----------T--- ---------ACAATA-AATGTTCAAAGAAGCATTATT---CTTAATA--TAAAAAAAG-A GA--AAAA--ACCCAAA-TGCCCAACA---ACTGATG-----AATAGATAAA--CAAAA- TG---------------------------------------------------------- --------------------TGGTATATCT----ATACAATGAAATGT------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------C---C----------------AGAA----------TAGGC AA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------A-----------------------------------T--------------- ------------------------------------CCATA-------------GAGA-- -------CA------------------------------------------GAAAGT--- -AGATTAGTGGT---TGCCA-----GGGGCT------------GGGAGG----------- ----GGGGAATG------------------------------------------------ --GGG-------AGTGAC------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TGC----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TAATG---------------------------------------------- --------GGTA----CGGGGTTT------------------------CTTTTTGGGGTG ATGAAA--------------------------ATGTTCTGGAATTAGATAGTGGTGATGG TTG-----------------------------------------------------CA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CAACTCTGTG-- -------------------------AATATA----------------------CTAAA-- ------------------------------------------------------------ ------------------------------------------------------------ -AACC-------ACTGAAT----------------------------------------- -----------TGCACACTTTAAAATGGTGAAT---------------TTTATG------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GTATG------------TGAATTATATCTCAATAAAG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------CTGTT ATTT >L1MA10 ------------------ACATCAAGAGACATCAGGAAATTG--GCAGAATTGGAG---G CTCTAGCCTTCA--TACTCCCA--------GTATTGGCAACCATCCACAGACATGAATAT CTTTATGGAAGCCACAG----AATC---------TAATTAAGAGGTTCC--------AAC AC---CTCAATGGGACCAAAAATTCAAGAATAGATTCATTGAAG-----------AAATT AAAA---AAACTAAT----------------------------------TTCACTTAACC T----------------------------------------------------------- -----TTGTCACCTCTATCCT---------------------AAGATAGCACAGGCTCAG TGCTAA-------GAGAGGTTCCCTCAGCC----CACAATTTCTCCCACATTAAATGAAA GAATCAAAGTAAACACCTGGCTTCCCAGCCTTGTTGAATACTTC-TCAGGATGCCCACTT C------------------TCAATGTTTCAGGTAGGTCTTGTGGGACCCA--AAACACTA AGAGGAACAGCATGGCTAAATCAT------------------------------------ -----------------------------------------------CTGGGGACAACTA AGAGCAGTGAAAAGGGGAAAA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------AATACACAG CAACTGCCACACAGTTCTCAACATCCAGTTGC---------------------------- ---CAATACTCCCAACGTACTCATGGACTT------------------------------ ------------------------------------CATCAAGAGGT------------- -------------------CCATCTGTAAACCCCACA----------------------- ----------------------------------------GGATGTCCTGCCTGAAG--- ------------------------------------------------ATCCCTTGACCA GCCAATCTGCAGCCAGATAATCTGCCCCA--------------AACCTCTA--------- -------------------GTGAGTTGCACCATGGGCATCCCATGTATGAACCATATGAA CT---------------------------------------------------------- ---------CCTGAAGACAACACATAGATTTCAACAGCAGGTGTATATTGTTGCAACCA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GCTCAACTTTGCTGG----------------TTTAGAAGAA GGCTCACAACC------------------------------------------------- --------------------------------TTGAAAACTTCAGAG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ CACTGCCATAATGAAAATAAACAAGAAGTTATCAGCACTAGTCTTGGCTTTGTAAGACTA AGTGAAGGCACACAATCCTAAC--TTTGCCCCTAAAAGAGGTCAAAAAAAAATG------ ---------GAATGGGTGCATCA--------------ATAGTAAATGTATGAGAGACCCA TAG--AATGTCTAGCTAGGCTCACTGGTGAAGGTCTTTCTCTCCCAAAGCCAGTTAGTAA AGACGGAAATATAAGATGC-------------------------------------CTGG GTGACTGCTTC---TTCAAATGCAAAG-------------------------------AC AGTAATGTAAAGATTCAAGGAACACAAAGAATCAATGAA--------------------- -------------------------------------ATATGACACCACCAAAGGGACAA AATAAAGCTATAGAAATCCACATAAATGAGATATAGAAATTG------------------ ------AACTGCCAGAAAAAGAA------------------------------------- ----------------------------------------------TTCATCTTAAAGAA ACTCAATAAACCAAGAAAGATCTCAAA--------------------------------- --------------------------------------------ATAACACAGAGACTC- -------------------ACAAAAAAACATACTAGAGAAAAAAATGAACA--------- -------------AAATGAGAAG---------------------------------TTCA ACAAAGAGATAAAAACCATAAAAAAGACCAAAATGG------------------------ -------------------------------------------AATTCTTGGTGTGAAAA ATATAATGTCTGAACTAAAAAATTAAAAAGATTTA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AAAAAAA------------------------------AAT T-----------AATTGAAGG--------------------------------------- ------------------------------------------------------------ ---------TGAGAAAAAAAAAATTCAATGAAATAGAAAATGGATTAACAAACTTAAAT- ------------------------------------------------------------ -----------AGAAAACT----------------------------------------- -----------TTAGAAATAATCC------------------------------------ --AGTTAAAAGAAAAAAAA----------------------------------------- ---GGAAAAAAATCAGATAGTAAAAAAAGACTTGTAGGATTATGGGACACCATCAAGCAA ACCAATATATGCATTATGGGAGTCTCAGAAGGAGAAGAGAAAAAGAAGAAGAAAGCTTAT ATAAATAAACAAAGACAGTCTGCAGAGCTTCT-------AGGAAAACAAAGAATCAAAAA AACACAATACCAC-----CAA------------AAGAACAAAATAAAGCT---------- CCAG---AGACTGATCTTA---------------AAAAAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGGATACTTATG AAAT------GCCATCAA------GTGAA------------CAAAGAGT---AATTATCT TTAATAA---AACTCAGTGAGCC----ACAAGAGAAAA---------------------- --------------------------------------AAATGA---TAGAAAAC----- ----------------------------------------T------------AAATTTC ATATTAGGAGAACATTGCATAAGTG---AAGTTAGAATT--------------------- ----------------------------------------TCAACAAAAAGATACACACC --------------------------------------TTTAAAAAGAAC---------- -----CAAACATAAA--------------------------------------------- ------------------------TTCT-GGAAAA--TGAAA---------AGTAA---- -AATTGATATA----CTGAAGAGTTCATCAG-------AGTC------------------ --------------------------------------------TCTTAATAGCAGAAT- -----TGGCC--AAGC------------------AGAAG---------GAAG-AAT-TAG TGAGCTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACAGGCTATCTGAAAAT---ACACAG------TCAA---------AGAG--- ------------------GATTAAAGACAAAAGTAGG---ATGAAAAAGAA--------- TGA-AGCATGCCTGCAG--GCTCTAGAAA-ATAGCCTC-----------ATGAG-GAATA ATCATCTGAG-TTATCGG-----CCTTAAGG--------------AGGAGGTAGGGAAAG AGATAGGGGTAT---------AAAGTTTATTCAG--GTAATTTTAAAAATTATTAC-A-G AAAACTTCCCAAATCT--------------------TGGAAGAGATATGA--ACATCCAG ATCC-----AGGAAGCTCAAAAAAT---CCCAAACAAGTT--------TAA--------- -----CCCAAAGA-----AGTTCTCCCCAA----------------------------GG CACATTATAATTAAACT------ATC-AAAAG---------TCAAAGAAA---------- ------------AAG--AAAGAA------------------------------------- --------TGAAAAAAGAAAAAGA---AAAAAAAC--------------TCATCAC---A TAT----------AAAG--------------GAGAAACCAT--AAGACTGT-C--AGCGG ATT--------TTTTAGCAGAA--ACGTTA-CAGG--CCAG-GAGAGAGTG--------- ----GGA-TGATATA-T-------TCAAAG--T-GCT-GAAAGAAAAA------------ -AGAATG--TCA--GCCAAGAA--------TACTAT----------ACCCA--------- --TAAAAGATGTCC-----TTCAGTGAATAA-------AGGAAGAAAGAAAGTCTTTCCT AGACAAAC-AAAAGCTGAGGGA-TTTCATCATCACTAGAC---CTGCCTTAC-AAGAAAT GCT--------------AAAGAG----------------------AGTTCTTCAAGTAGA AAT--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AAAACTCACTGGTAAAGGTAAGTATATAGACAAATTCAGAATGCTCTAA TACTGTAATGGTGGTGTGTAAATCACTTTTAATC---CTAGTATATAAGTC--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AAAAGACAAAAGTATTGAGAA TATCT------------------------------------------------------- ---------------------------------ATATCCACACAAAAATTTGTTAATAAA TACACAACATAAAAAGAAGTAAACTATGATATCAGTAACATAAAGTGAGGGAGGAAAACA TAAAA------------------------------------------------------- -------------------------------------------------------TGTTG AGTTTGTGTATGTGATTGAAGTTAAGTTATCAGCTTAAA--------------------- ----------------------------------ATAG-------------ACTGTTATA ACTATGAGAGGTTCAATGTAAACTTCATAGTAACTACAAAGAAAAAACCTATAGCAGAT- ------------ACATAAAAAAGATAAAGAGAAAA-----------GAATCAAAGCATAT CACTACAA----AAAAAATCAAA----------------------AAAAATCATCACAAA ----GG------AAGACAGCAAG--AGAGGA-------AGAGAGG-------AACAAAAG AACTACAAAAGAGATAGAAAACAATTAAC---------------------------A--- ------------------------------------------------------------ ----------------------------------AAACCTATCAATAA------------ -------------TTAC-AATAAATA-TAAATGAATT--AAATTC---TCCAATCAAAAG ACATAGAG--TGGCTAAATTGATT------------AAAAAAACAAGATCCAACTA---- ---TAT-GCTGTCTATAAGAG-ACTCACTT-TAGCT--TTAAGGACACACATAGGCTGAA AG--TAAAGAAA--TGGAAAA-AGATATTCCATGCAAATGG------TAACC-------- -------------AAAAG-AGAGCAG--GAGTGGCTATACTTATATT-AGATAAAATAGA TTTTAAG-TA----------AAAAACTGTCACAAAAGAC-AAAA-AGGGTCATTATAT-- ----AATGATAAA---AGGGTCAATTCATC--AAGAAG--------AT-ATAACAATTGT AA-----------------ATATATATGCACCCAACATCAGAGCACCTAA--ATATATAA AGCAAATATTAACAGAACTGAAGGGAGAAATAGACAGCAATAC---------AATAATAG TAGGGGACTTCAATACCCCAC-----TTTCAATAATGGATAGA----------------- ----TCATCCAGAC------AGAA-----AATCAATAAGAACATT--GGAATTG------ --AACAACACTATAAACCAAATGGAC-CTAACAG--ATATATACAGAA--CATTTCACCC AAAAGCAC---CAGAATATACATTCTTCTCA-------AGTACACAT---GGAACATTCT C------CAGGATAGATCACATGGTAGGCCACAAAACAAG-------------------- -TCTTAACAAATTTAAAAAGA--TTGAAAT----------------CATATCAA------ -GTATTTTTTCT---GACCACAATGAAA-TGAAACTAGAAATCAATAATA--------GA A-------------GG-AAATTGG---GAAAATTCACAA----ATACGTGGAAATTAAAC AACACA-TTCTTGAA---CA-ACAATTG--GGTCA---AAAAAGAAAT--AAA-AAAAGA AATTAAAAAATATCTT---GAAAC------------------------AAATAAAAATAT -AACAAAAAT--AAACAAAAATTTTTGGGTGATAAAA-AAAAGCAGTATTAAGAGGAAAG --TTTATAGTGA-AAACATTTTTTTTAAAAAAA---AAGA--AAGATCT---CAAATAAA ------CAACCTAACTTTACACCTCAA---GGAACTAGAAAA---AG---AAAAACAAAC TAAGCCCA-AAGTTAGCA------------GAAGGAAGAAAATAAT-AAAAATTAGAGCA GAAATA---AATGAAATAGAGAATAGAAAAA-CAA---TAGAAAAA----AATAAAAAAA -ATAGT-------TTGTTTTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------A AA-----AA------TTGACAAACCT---TTAGCTA------GACT-------------- AAGAAAAAAGAGA---------AAAA-AAACACAAATAAA-------------------- -----TAAAA---T---------CAGAAATAAAAAA------GGAGA---CATTACAACT G--------ATAC-CACAGAAATA-AAAAGGATC--ATAAG---------AGACT----- -------------------ATTATGAACAA-TTATATGCCAACAA--AT---TGGATAAC CTAG---AAGAAAT--GGATAAATTCCT--A---GAAACA---------TAC-----AAC CTACCA------AGACTGAATCATGAAGAAATAGAAAATCTGAAC--------------- --------AGACCA------A------TAACAAATAAAGAGAT----TGAAT--CAATAA -TCAAAAACCTCCCAACAAAGAAAAG--CC-CAGGACC--AGATGGCTTCACTGCTGAA- TTCTA------------CCAAACATTT----AAAGAAGAATTAATA-CCAATT-----C- ----TTCTCAAACTCTTCCAA-------AAAACTG-AAGAGGAGGA-----------AAC ACTTCCAAACTCATTTTATGAG---------GCCAGCAT---TACCCTGATACC--AAAG C-----------------------CAAA---AAAAACA-CACC----AA---------AA AAAAAAAAT----------------------ACA------GGTCAATAT--ATC----TA ATAAACATGGAT------------------------GCAAAATTTT-TCAA--------- ------AAAAATACTAGC-AAACTG------------------AATAT------------ ---T-CA--ACA-------------GCACATT---------AAAAGGATCATACA--CCA ----TGAT------------CAAGTGGGA-TTTATCCCTGGGA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATGC----AAATCAATAAATGTG--ATA CACCAC---------A------TTAACAG----AATGAAGAATAAAAAT---CACATGA- ----TCATCTC---AATA----------GATGCAGA-AAAAG---CATTTGACAA---AA TTCAACATTCTTT-------------------CATGA---------T-AAAAAC-TCTTA --ACAAATTAGGTATAGAAGGAAAAT-----ACCTCAACATAAT---------------- -----------AAAGGCCAT-ATAT-GAAAAGCCCACAGC-----------TAACAT--C ATACTCAATGGTGAAAA-A-----CTGAAAGC-TTTT---CCTCTAAGAT----CAGGAA CAAGACAAAGATGC-------CCACTCT-------------------------------- ------------------------------------------------------------ ------------------------TACCACTTCTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATTAG------GCAAGAA---AAAGA--AATAAAAGGC ATTCAAATTAGAAA-------GGAAGAAGTAAAA--TTATCTCTG-----TTTGCAGATG AC--ATGATCTTA-------TATATAGAAAACCCT---------------AAAGA---CT CCATCA---------AAA--AACTTTTAGAACT------------AAA--TAAATTCAGT AAAG--TT-------------------------GCAGGATACAA--------------AA TCAACAT------------ACAAAAAT----CAGTTGTGTTTC--TA-TATACAAA---A ATAAACTATCTAA------------------AAAAAAAATTAAAA----AAAATAATCCC ATTTACAATAGC-ATCAAA---AAGAATAAAATACTTAGGAATAAATTT--------AAC -CAAGGAGGTGAAAGATCTAT---ACACTGAA--AACTATAAAACATTGATG-AAAGAAA TTAAAGA-----------AG------------------ACAC--AAAT--AAATGGAAAG ATAT------C---TCATGTTCATG------GATTGGAAGAATT-----AATA-TTGTT- ------------------------AAAATGTACA-CA-ATACCA-AA------------- -------AGTCTATTCAA--TTCAATTCAATCTCTAATAAAAT---------TCCAAAG- AC-------------TTTTT---------------------------------------- --AAAAAAAATAA---AAA------AAAAAA--CTAAAA-TTCATATGGAA-------CC ACAAAACCTTCT---A---ATAGCCAAAGCAATCTTAAGTAAAAAAAACA---AAGC--T -------GGAGGCATCATA---CTTCCTGATTTCAAAAT-----ATATTACAA---AGCT ATAGT-AATCAAAAC-AG------TATGGTACTGG--CA-----------------TAAA AACAGACA------TATAGAC--CAATGGAACAGAATAGAGAGCCC------AG--AAAT AAA---CCCACACATATATA----GTCAA---TAATTTTG---AACAAG--GGTGC--CA AAATTAAAC--AAGGG------GAAAAG----ATAGT--------CTCTT--CAATAAAT TGTGTTG----------G-GAAAAC--TGG-A-TATCCA---------------CATGC- AAA---------AGA--ATGAAATTGGACCCTT----ATCT---------------TAAA AC--ATATACAAAAA-TCAACT-CAAAATGGATTAAAGACTTAAATGTA--AGACCTGAA ACC-AT------------------------AAAACTCCTAGAA----------------- ------GAAA--ACATA------G---------GGA---------AAACTCCTT--GAC- --ATT-----GA-CCTTGGCAATGATTTTTTGGATAT-GACACCA-AAA----GCACAGG CAAAAAAAGCAAA----A------AT---AAAA--AAATTGGGATTAA--AT-------- -------------------------------------------------------C--AA CTAAAAAAGTT-CTGCA---CAAC-AAAAGAAACAATCAAC-AAAA-AAAAAAG--GAAC CTAA--AAAA--TAGGGAG--AAAATATTT---GCAAATCATATAT--------CTGATA AGGGGTTAA-------TATCCAAAATATATA--AGGAA--CTCCT-----ACAAC----- ----------------------TCAATAGAAA------AAAAAC---------------- AAAA-------TTAAAA-----------ATGGGCAAAAAAACTACAATAGA--CCTGAAT ---AGACATTTCTCCAAAGAAGACATACAAA--------------TGGCCAAC-AGGTAT ATGAAAAGATG----CTCAACATCACTAA-TCATCAGGGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TATCACCTCACACCTGTTAGGATGGCTA-- ----TTATAAAAA---AAAAAAAA------------AAAACAA--GTG--TTGGT-G--- ---------------AGGATGTGGAGAA-------------------------------- -----AAGGGAACCCTTGT-ACACTGTTGG--TGGGAA---------------------- -------------TGTA-------------AATTG-GTACAGCC--------ATTATGG- -------AAAAAA-GGATAGGG--GTTTTCTTAAAAAATTAAAA--ATAAAACTATCA-T ATATGA-ATCCAGCAATCCCATTTCTGAG-TATATA-TCCAAAAG-AAT--TGAA----- -------------------ATCAGGAT-CTCAA--AAAGATATCTG----------C--- ---------ACTCC--CATGTTCATTGCAGCATTATT---CACAATA-GCCAAGATAT-G GA--AACA--ACCTAAA-TGTCCATCA---ATGGATG-----AATGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTATATAC----ACACAATGGAATAT--TATTCA-GCC TTAAAA----------------------AAGAAAGAAATCCTGCCATTT----------- ------------------------------------------------------------ -GTGACAACATGGATGAAC-C---T----------------GGAGAACATTATGCTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GACAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAG---- -----------------------------AAAAATAC-TACATG--------ATC----- ------TCACT---TAT------------------------ATGTGGAAAT---CTAAAA T-------A--------------GTCAAA---------------C--------------- ------------------------------------TCATA-------------GAAG-- -------CA------------------------------------------GAGAGT--- -AGAATGGTGGT---TGCCA-----GGGGCTGGG---------GGGGGG----------- ----GGGAAATG------------------------------------------------ --GGG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AGGTGTTG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------TTCAATG---------------------------------------------- --------GGTA----CAAAGTTT------------------------CAGTTATGCAAG ATGAAT--------------------------AAGTTCTGGAGATCTGCTGT-------A CAA-----------------------------------------------------CATA GTGCCTATAGTT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACAATACTG-- ----------------------TATTGTACT--------TTAAAAATTTG---CTAAG-- --------AGGGTAGATCTTATGTTAAGTGTTCTTACCACAAAAAAAACAAATTATAAAT ACATAAAAACCAATATAATAAGGAGGGGCAGGAGGAAACTTTTGGAGGTGATGTATATGT TTATG-----GCCTTGATT------------------------------ATGGTGATGGT TTCATGGGTA-TATACT-------------------------------TATCTC------ ------------------------------------------------------------ ----------------------------------------CAAACTCATCAAGTTGTCTA CATTAAATATGTACAGTTT-----TTGTATGTCAATCATACCTCAATAAAGCTGTTTAA- -------AAAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MA4A ------------------------------GGCTTCAAGATG--GCTGACT-AGAGGCAT CTGGTACTCGC---CTCCTCCA--------CAAAGAAGAACC------------------ ---------------------AAAA---------TAGTGAGTAGATAAT--------CAC AC--TTCGAATAG-------ATCATCTAAGAGAGAACACTGGAA-----------TTCAA CAGA---GAAGTGACAGGA------------------------------AACACCTAAGG C-----------------------AAGGAAGGAGAGGGAAGCGAGG-------------- ----------CAGCCTGCTTG-----------------GCTGGGATTGGCTGGGAGCCT- ---------------GGAGAGGCTCCCCAA----TGTGG----------------GGAAA GGGTAAGTGA---------------------------GAGACCC-CCAGTGGTCCACATT C-------------------------CCACTGTGGACTCCTGCAATCCTA----GCCATG GGAGAGCCCCTCGACCCT---CAC------------------------------------ ------------AGGCCCTGAGACTAACATAG------------------GGAGCTGCCT GGAGACTGTACGATGGCATTG---------CTCCAGAGAGGGAGCTCATGCTGGGT---- ------------------------------------------------------------ ----------------------------CCCACACACCCCCCGAGTCCTAAGCAGCTACA GCATGGCGCCATTTTGAGAGCCCAGCCCCCACCAGACTGCATCCTGCCCTGGG------- -----GCCCAACAG-CCCCTGCATCTCCACATCCCTG----------------------- ---GAGCCCCACTGACATTCCCTGCCCACAGCCACCGCCGCTGCTGG--CTGCTG----- ------------------------------------CTGCCAGGGCTGAAGCGCGAGCCA TTGGCAGTGACCCCACC--CCCCCCGGAGGCGGGGCTGCTGTGCATTTTCATGTGCCCTG AGGACAGGCTCCCCTACCTGC-------------------AGCTGCCACCGCTGTGG--- ------------------------------------------------------GCTGCC ACGGCCGGGGCGAAAGCAGGGGTGCCAGGGGCTACCCCGGCCCAACCCAATGCCGG---- --------------------------CTGCTGCTG----------------GGCCAAAGT GT-------------GAGCGAAGCGCATGCTCCCCAGCCACCTGCCTA------------ -------TGGCTG---------------CTGCCACTGAAAGCAACCCCA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------CCCTCCCCAGTAG-------------------CAGGGCT GCAGTGCAGCCACTGCTGCCCCCACCTGAGCATTCCGCCAGGGGCCTGG----------- --------------------------------------GGATCACCCTGCCCCTGCCTAC CACAGCCAGTGCCTGCATGCACCACTGGGGGGCCTGAGGACAGGCCTGCCCGGCCCGGCT CCACCCC----------------------------------------------------- ------------------------------------------------------------ CCCAGTGCCTGAGCATGC-------------------------CGTCTGGGGGCCTGGGG ATCGCCCAG------CCCAGTC--CACCACCATTGGCACCTGAGCACTCCTCCCAG---- ---------GGGCCTGAGGTTGG--------------GC----------------CCACC CAA----------------------CCTGCTGCACCACAGCTGGCACC------------ ------------CACCTGCATGTGCCACCT--------------------------GTGG GCCTGGGGACTGGCCTGCCCAGCCCATTGCAGCCACCGCCAAC---------------AC CAGCGTGGAC--TGCTTG--------GGAGCCAGAGGGTTGTCCTGCCACTGCTA----- -------------------------------------CTGCCATTGCCCATGCCATGCCT GCTGCCCAGGGGCCCGAGAACCTGCCCACCTGCCTGGCCCAC------------------ ------TGCTGCCACTGCTGGCACCT---------------------------------- ------------------------------------------------------------ -----------GAGCAAGCCACCTGGAGGCC------------------------CAAGA ATCGGC------------------------------------CTGCCTGGACCCACTAAC ACCGGTGCCAGCGTACACCACCCTGGGGCCCAAGGA-----CAGGCATGCTCAGCCCACC ACTGCCACCACTGGGGCCCAAGG---------ACTGGCCCACCTGGCATCCCCGTCCCCA GCAAAACTTCACCACAGCCTCCACTAACAACTGCAC------------------------ ----------------------------------------------CCTAAGCCACTGAG G---AAATCACAGACACCACTGATG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CTGTTTACAGCCAAAGAAATCATACAGAGACTACACTA CTGCATGCACCCA----------------------------------------------- ------------------------------------------------------------ --------------------GAATCAA------------------------------AGC C-----------AAAGTGCCCTACCCAACCAACACC------------------------ ------------------------------------------------------------ -------------------------------------ATAGATACATCTTCAGG------ ------------------------------------------------------------ -----------AAAAAGTC----------------------TTC---------------- -----------CCCTATGAAAGC------------------------------------- --AAATTCAAAAAATTGGA----------------------------------------- ---AGAAGTGACTGTTACACC--------------------------------------- ---------------------------AGACATAAATACCGCAG---------------- ------ATATCAAA-------ATAAGGACACA-------GGAAACACGAAAAAGCAAGGA AATATGACACCTC-----CAA------------AGGAACACAATAATTCT---------- CCAG---CAACAGATCCCA-------ATC-------AAAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGA-AATTTATA AAAT------CCCAGAAA------AAGAA------------TTCAAAAT---AATGAT-A TTAAAGA---AGCTCAGTGAGAT----ACAAGAGAAAT---------------------- ------------------------------CAAAAAAAAAAATA---AAAAAAAA----- ----------------------------------------T------------------- -AAAAAAAAAACAATTCAGGATATG---AATGAGAAATT--------------------- ----------------------TACCA-------------AAGA------GATAGATATC --------------------------------------ATAAAAAAGAAC---------- -----CAAACAGAAA--------------------------------------------- ------------------------TTCT-GGAAC---TGAAG---------AATTC---- -ATTGAATGAA----ATACAAAATACATTTG-------AAAG------------------ --------------------------------------------CTTCAACAATAGACT- -----AGATC--AAGC------------------AGAAG---------AAAG-AAT-TTC AGAACTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACAGGTCTTTTGAAA-T--AACCCAG------TCAG---------ACAA--- ------------------AAATAAAGAAAAA---AAA---AAAAAAAAAAAAAAAAAGAA TAA-ACAAAGCCTATGT--GACATATGGGAACACCATA-----------AAGTA--ACCA AATATTTAAA-TATTTTGGGTGTCCCAGAAG--------------GCGA---AGAGAAAA CAAAAGGGTTAG---------AAAACCTATTTAA--T--------AAAATAATAGA-T-G AAAACTTCCCAAGTCT--------------------AGCAAGAGATTTAG--ACATCCAG ATAC-----AGGAAGCTCAGAGATC---CCCAAA-TAGAT--------ACA--------- ---A-TTCAAAAA-----GGTCTTCTCCAT----------------------------GG CACATTATAGTCAAACT------GTC-AAAAG---------TCAAAGACA---------- ------------AAG--AGAGAATTC---------------------------------- --------TAAAAACAGCAAGAGA---AAAGCATC--------------TAGTCAC---C TAT----------AAAG--------------GAACCCCCAT--CAGACTAA-C--AGCAG ATT--------TCTCAGCAGAA--ACCTTA-CAGG--CCAG-GAGAGAATG--------- ----GGA-TGATATA-T-------TCAAAG--T-GCT-GAAAGAAAAA------------ -AAC-TG--CCA--CCCAAGGA--------TACTAT----------ATCCA--------- --GCAAAATTATCC-----TTCA-TAAATGA-------AGG-AGAAATAAAGTCTTTCCC AGACAAGC-AAAAGCTGAGGGA-ATTCATCACCACTAGAC---TAGCCCTAC-AAGAAAT GCT--------------TAAGGG----------------------AGTCC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TAAAC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------CTGG---------------------- ------------------------------------------------AAATAAAACCCA CTGGTAGAGCAAACACACAAATAAGGAAGAGAAAG-----------GACTCAAATGTTAC CACTAC------AGAAAACCACC----------------------AAAC-----CACAAT ----GA------TAAACAATAAG--AGAGAA-------AGAAAGG-------AACAAAGG ATATACAAAACAACCAGAAATCAATTAAT---------------------------A--- ------------------------------------------------AATGACA----- --------------------GGAATAA--AACC-TCACATATCAATAA------------ -------------TAAC-CTTGAATG-TAAATGGATT--AAATTT---TCCACTTAAAAG ATATAGAC--TGGTTGAA-TGGAT-------------TAAAAAAATTATCCAAATA---- ---TATGGTTGCTTAAAAGAA-ACTCACTT-TACCT--GTAAAGACACATATAGACTGAA AG--TAAAGGGA--TGGAAAA-AGATATTCCATGCAAATGG------AAACC-------- -------------AAAAG-CAAGCAG--GAGTAGCTATACTTATATC-AGATAAAACAGA CTTTAAG-TC----------AAAAACAGTAAAAAAAGAC-AAAG-AAGGTCATTATAT-- ----AATGATAAA---GGGATCAATCCAGC--AAGAGG--------AT-ATAACAATTCT AA-----------------ATATATATGCACCCAACACTGGAGCACCCAG--ATTCATAA AGCAAATATTACTAGATCTAAAGAGAGAGATAGACTCCAATAC---------AATAATAG TGGGGGACTTCAACACCCCAC-----TCTCAGCATTAGACAGA----------------- ----TCATCTAGAC------AGAA-----AATCAACAAAGAAACATTGGATTTA------ --AACTGGACTTTAGACCAAATGGAC-CTAACAG--ACATTTACAGAA--CATTTTATCC AACAACTG---CAGAATACACATTCTTCTCA-------TCAGCACAT---GGAACATTCT C------CAGGATAGACCATATGTTAGGCCACAAAACAAG-------------------- -TCTCAACAAATTTTTAAAAA--TTAAAAT----------------CATATCAA------ -GTATCTTCTCA---GACCACAATGGAA-TAAAACTAGAAATCAATACCA--------AG A-------------GG-AACTTTG---GAAACTATACAA----ATACATGGAAATTAAAC AACATG-CTCCTGAA---TG-ACCATTG--GGTCA---ATGAAGAAAT--TAA-GATGGA AATCAAAAAATTTTTT---GAAAC------------------------AAATGAAAATGA -AAACAAAAC--ATACAAAAACCTG-TGG-GATACAGCAAAAGCAGTGCTAAGAGGGAAG --TTTATAGCAATAAATACCTACATCAAAAAAG---TAGA--AAGATTT---CAAATAAA ------CAATCTAACAATGCACCTCAA---GGAACTAGAAAA---GC---AAGAACAAAC CAAACCCA-AAATTAGCA------------GAAGAAAAGAAATAAT-AAAGATCAGAGCA GAACTA---AATAAAATAGAGACTAAAAAAA-AAA---TAAAAAGGATC-AATAAAATAA -AAAGT-------TGGTTTTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGATAAACCA---CTAGCTA------GACT-------------- AACCAAGAAAAAAAA---A---GAGA-AGACCCAAATAAA-------------------- -----CAAAA---T---------CAGAAATGAAAAA------GGAGA---CATTACAACT G--------ATAC-CACAGAAATA-CAAAAGATC--ATCAG---------AGACT----- -------------------ATTATGAACAA-CTATATGCTAACAA--AC---TGGAAAAC CTAG---AGGAAAT--GGATAAATTCCT--G---GAAACA---------TAC-----AAC CTACCA------AGATTGAATCAGGAAGAAATAGAAAACCTGAAC--------------- --------AGACCA------A------TAATGAGTAGTAAGAT----TGAAT--CAGTAA -TAAAAAGTCTCCCAACAAAGAAAAG--CC-CAGGACT--GGATGGATTCACTGCCAAA- TTCTA------------CCAAACATAT----AAAGAAGAACTAATA-CCAATT-----C- ----TTCTCAAATTATTCAAA-------AAAATTG-AAGAGGAGGG-----------AAT TCTCCCTAACTCATTCTATGAG---------GCCAGCAT---TACCCTGATACC--AAAA C-----------------------CAGAC--AAGGACA-CAAC----AA---------AA AAAGAAAACT---------------------ACA------GGCCAATAT--CCC----TG ATGAACATAGAT------------------------ACAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACCA------------------AA--T------------ ---T-CA--ACA-------------GCACATC---------AAAAAGATAATACA--CCA ----TGAT------------CAAGTGGGA-TTTATACCAGGGA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATAC----AAATCAATAAATGTG--ATA CATCAC---------A------TCAACAG----AATGAAGGACAAAAAC---CATATGA- ----TCATCTC---AATA----------GATGCAGA-AAAAG---CATTTGATAA---AA TTCAACATCCCTT-------------------CATGA---------T-AAAAAC-TCTCA --ACAAACTAGGCATAGAAGGAACAT-----ACCTCAAAATAAT---------------- -----------AAAGGCCAT-ATAT-GACAAACCCACAGC-----------TAACAT--C ATACTGAATGGGGAAAA-G-----TTGAAAGC-CTTT---CCTCTAAGAA----CTGGAA CAAGACAAGGATGC-------CCACTTT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATCAG------GCAAGAG---AAAGA--AATAAAAGGC ATCCAAATTGGAAA-------AGAGGAAGTCAAA--TTGTCCCTC-----TTTGCAGATG AC--ATGATCTTA-------TATCTAGAAAAACCT---------------AAAGA---CT CCACCA---------AAA--AACTCTTAGATCT---------GATAAA--TAAATTCAGT AAAG--TT-------------------------GCAGGATACAA--------------AA TCAACAT------------ACAAAAAT----CAGTAGCATTTC--TA-TACACCAA--TA ATGAACTAGCTGA------------------AAAAGAAA-TCAAG----AAGGCAATCCC ATTTACAATAGC-TACAAA---AAAAATAAAATACCTAGGAATAAATTT--------AAC -CAAGGAGGTGAAAGATCTCT---ACAAGGAA--AACTACAAAACACTGATG-AAAGAAA TTGAAGA-----------GG------------------ACAC--AAAC--AAATGGAAAG ACAT------C---CCATGCTCATG------GATTAGAAGAATT-----AATA-TTGTT- ------------------------AAAATGACCA-TA-CTGCCC-AA------------- ----AGCAATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------ACCAATA- TT------------ATTTTT---------------------------------------- --TACAGAAATAA---AAA------AAAAAATCCTAAAA-TTTATATGGAA-------CC AAAAAAGAGCCC---AA--ATAGCCAAAGCAATCCTGAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACA---CTACCTGACTTCAAAAT-----ATATTACAA---GGCT ATAGT-AACCAAAAC-AG------CATGGTATTGG--TA-----------------TAAA AATAGACA------CATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAT AAA---TCCATATATTTACA----GCCAAC--TGATTTTT---GACAAA--GGCAC--CA AGAACATAC--ATTGG-----GGAAAGG----ACACC--------CTCTT--CAATAAAT GGGGCTG----------G-GAAAAA--TGG-A-TAACCA---------------TATGC- AGA---------AGA--ATGAAACTAGACCCCT----TATT---------------TCCC CC--ATATACAAAAA-TCAACT-CAAAATGGATTAAAGACTTAAATGTA--AGACCCGAA ACT-AT------------------------AAAACTACTAGAA----------------- ------GAAA--ACATA------G---------GGA---------AAACACTTCAGGAC- --ATT-----GG-TCTAGGCAAAGATTTTATGGCTAA-GACCTCA-AAA----GCACAGG CAACAAAAACAAA----A------AT---AGAC--AAA-TGGGACTAT--AT-------- -------------------------------------------------------T-AAA CTAAAAAGCTT-CTGCA---CAGC-AAAAGAAACAATCAAC-AGAG-TGAAGAG-ACAAC CTGT--TGAA--T-GGGAG--AAAATATTT---GCAAACTATTCAT--------CCAACA AGGGACTAA-------TATCCAGAATATACA--AGGAA--CTCAA-----ACAAC----- ----------------------TCAACAAAAA------AAAAACAATAAAAAAAAAAAAA AATAATCCCA-TTAAAA----------AGTGGGCAAA-----------GGA--CATGAAT ---AGACATTTCTCAAAAGAAGACATACAAA--------------TGGCCAAC-AGGTAT ATGAAAAAATG----CTCAACATCACTAA-TCATCAGGGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TATCATCTTACCCCAGTTAGAATGGCTA-- ----TTATTAAAA---AGACAAAAA-----------AAAAAAAATATG--TTGGT-A--- ---------------AGGATGTGGAAAA-------------------------------- -----AAGGAAACTCTTAT-ACACTGTTGG--TGGGAA---------------------- -------------TGTA-------------AATTTAATAAAACC--------AATAAGG- -------AAAAAA-ATTTGGAA--ATTT-CTTAAAAAACTAAAA--ATAGAACTACCA-- -TATAA--TCCAGCAATCCCACTACTGGG-TATTTA-TCCAAAGG-AAA--AAAA----- -------------------ATCAGTAT-ATCAA--AGGGATACCTG----------C--- ---------ACTCC--CATGTTTATTGCAGCACTATT---CACAATA-GCAAAGATAT-G GA--ATCA--ACCTAAG-TGTCCATCA---ATGGATG-----AATGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTATATAT----ACACAATGGAATAC--TATTTA-GAC ATAAAA----------------------AAGAATGAAATCATGTCATTT----------- ------------------------------------------------------------ -GCAGCAACATGGATGGAA-C---T----------------GGAGGTCATTATGTTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GGCAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAG---- -----------------------------ACAAATAT-CACATG--------TTC----- ------TCACT---CAT------------------------ATGTGGGAGC---CTAAAA A-------A--------------GTTGAT---------------C--------------- ------------------------------------TCATG-------------GAGG-- -------TA------------------------------------------GAGAGT--- -AGAATGATAGA---TACCA-----GAGGCTGGG---------AAGGGT----------- GTGTGGGGGGGG------------------------------------------------ --GGG-------GGGGGG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GGG--------TGATGAAGAGAGGTTG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GTTAATG---------------------------------------------- --------GGTA----CAAACATA------------------------CAGTTAGATAGA AGGAAT--------------------------AAGTTCTAATGTTTGATAGC-------A GAG-----------------------------------------------------TAGG GTGACTATAGTT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACAACAATG-- ----------------------TATTGTATA--------TTTCAAAATAG---CTAGA-- -------------AGAGAGGACTTGAAATGTTCCCAACACATAGAAATGATAAA------ ---------------------------------------TACTTAGGGTGATGGATACCC TAAATACCCTGACTTGATC------------------------------ATTACAC---- ------ATTC-TATGCA-------------------------------TGTAAC------ ------------------------------------------------------------ ----------------------------------------AAAATATCACAT---GTACC CCATAAATATGTACAAATA------------TTATGTA----TCAATAAAA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MA5 --------------------------TGACATCAGCAAGTTG--GCTGACT-ACAAGGGG CCCACAACTCT---TCTCTCCA--------CCAAAAACGACC------------------ ---------------------AAAA---------CAACGAATAGATAAC--------TAC AC--TTTGAGTAG-------AATATCTAAGGGAGAGTACTGGAA-----------TTCAG CAAG---GGAGTGACAGAAACCCTGGGAGGCATAGAAACTCAGGATGGCCGCATAGAGAG C---------------------GGAGCTAAGCAGAAGCATGCCACC-------------- ------------TCGGGGCCTCAGCATCGCGACTGGCCTGAACCGCCAGCCAGGAGTGAC CCTGACCGTC---GAGA---GACTCTTCAT----TGCAG----------------GGAAA AAGTAAGTGG---------------------------GAGATCC-CCAGCAGCCCCCATT C-------------------------CCACCATGGACGCCTGCAATCCTA----GCTACA GGAGAGCCCCACAGCCCT---CAC------------------------------------ ------------AGGCCCTGAGCCCAGTATAG------------------GGAGCTGCCT GGAGTCCACACGGCTGCATTG---------TCCCAGAGAAGGAACCCACACTGGGT---- ------------------------------------------------------------ -----------------------------CCCCCCCCCCCCCCTGGGCTCAAGGTGTCCT GGCACGGGCTGCCCTCAGCTTCTGTGATTTTGAGAATGGAGCCACTGCTAGAC------- -----TCCATCCTT-CCCTGGGGCCCAATTGCCCCCGCATCC------------------ ---CCACCTCCCTGGGGCCCTTCCCTGAGCCCCCCATCCCCCCGGGAGGCTGCGCCTTCG ------------------------------------CAGCCCCAGCTAGACCC------- -------------------AGTGGTGGAGCTGTGACCCGGGCACCTGGGCCCACTGGAAG ATCGGTGCCGTGGCTCAGCGCCCCAGCTGC----------ACCCGCCTGTTCGGGGC--- -----------------------------------------TCATGCAGTGCCCTACACT CCCAGGAACAGGTGGTGCAGCACATCAGG------------------------------- -------------------GAGGCTACCCCCAGCA----------------CTCAGGGAG CC-------------GATCCACCCGCTCCCCACGGCCCT--------------------- -----GGGGCCTG---------------CCGCCCCGG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------CGT CCCGCCGCCAGCCGTCACCCCTCCCCCTCCAGCG-----------------------GCT GAGCCACCCTC------------------------------------------------- -------------TGCCTCCGTGCGCCCCCCGCCCTGCTGGGCTGCC-ACCCACGCCGCC CACCCCTGCCCAAGCCGCTCGCCTCACAGAGTCTGT------------------------ ------------------------------------------------------------ ------------------------------------------------GATATACTGACC CTCACTATTTCAGGGTCTAAAGTCACTACTACACAGTACTTAGTGCCCTGGAAGAGATGC TCCAAAAAC------CCTTGCC--AGTCACTGCTGTAGTTTGCTTCCTTGGGCTGGGAAA GAAACAAAGACAGGCATCCAGGGCAAATACTTCCACTGTTGCCCAGGTCAGTGCCACCAC TAA-----------------------AAGCCGCAGCTTCCCCAGTTACCCTCCTCTTCGG CCTGCTTTGCCCAGACTGTCCATATGATCCATGTTC--------------------ACTA CTGCCGAGCCCGTGCTGGTCCCACCCTTCGCGCAGATATCTCG---------------CC CGGCCTGCCC--GCCATAGCCACGCACCCCTCCCAGGGTTGTAAGGCTGGGGCCCCGCCT C------------------------------------CGTCCACCCTCCCCTCACAAGGC GAAGCGCCGCCGTGTCCCCGC-------------------GA------------------ ------TTCGCCCAGGGGTTCGCCCT---------------------------------- ------------------------------------------------CACTTCAGGCCA ACACCATGGTGGCAGAGCCACCACATGCCCCTTTGCCTGGCACCCC---------CGGCC ACCCCCGCCTCCCGGACAGCGGTGC-----------------TGGCCCCTTTGCGCGCTC TCTGGGGTCCTGGAGCCGGGCCGACCGGGGCCCCCCGCCCCCAGGAAAGCA--------- ------------------------------------------------GCAACTTTCCCC ACTGG-------------TGCCACAAACTCCTGCAG------------------------ ----------------------------------------------CCTAGGCCACTGAG G---CACTCGCAGACATTGCTGACA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------TTGATTACAGCTAAAGAAATTATACAGAGACTACACTA CTGCACCCACCCA----------------------------------------------- ------------------------------------------------------------ --------------------GAACCAA------------------------------AGC C-----------AACGCACCCTACCCAACCGACACC------------------------ ------------------------------------------------------------ --------------------------------------ATAGGACCCATCTACAGG---- ------------------------------------------------------------ -----------AAAAAGTC----------------------TTT---------------- -----------CCCTATAAAAGC------------------------------------- --CACTCCATAAAATTGGA----------------------------------------- ---AGAGGTGACTGTTCCACC--------------------------------------- -------------------AGATGCGCAGATTGATGATGCACAG---------------- ------ACATCAAC-------ACAGGGACACA-------AGAAACATGAAAAAGCAGGGA AATACGATGCCAC-----CAA------------AGGAACATAATAATTAT---------- TTGGTAACAGCAGACCCCA-------ATG-------AAAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GGA-AATCAATT AATT------GCCAGAAA------AGGAA------------TTCAAAAT---AATGAT-T TTAAAGA---AACTCAATGAGAT----ACAAGAAAATA---------------------- ------------------------------TAGATAGATCATTC---AAAAAAAT----- ----------------------------------------A------------------- ----------AAAATTTATGATCTA---AATGACAAATT--------------------- ----------------------CAACA-------------AAGA------AAAAAATAAA --------------------------------------AAAAAAAAGAAC---------- -----CAAACAGAAA--------------------------------------------- ------------------------TATT-GCAAC---TGAAG---------AATTC---- -AATGAATGAA----ATAAAAAATACAATCG-------AGAG------------------ --------------------------------------------CTTCAACAATAGACT- -----AGATC--AAGC------------------AGAAG---------AAAG-AAT-TTC TGAACTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGATAGGTCATTTGAAA-T--AACTCAA------TCAGA--------AAAA--- ------------------AAAAAAAAAAGAAATAAAA---ATGAAAAAAGA--------A TAA-AGAAAACTTATAA--GATTTATGGG-AACACATT-----------AAGTG-AAAAA AATATTCAAA-TTATGGG--AGTTCCAGAAG-----------------AAGAAGAGATGG AAAAAGGCATAG---------AAAACCTATTTAA--T--------GAAATAATAGC-T-G AAAACTTCCCAAGTCT--------------------TGGGAGAGATATGG--ACATCCAG ATCC-----AGGAAGCTCAAAGATT---CCCAAA-TAGAT--------TCA--------- ---ACCCCAAAAA-----GGTCTTCTCTAA----------------------------GG CAAATTATATTCAAATT------GT--AAAAG---------TCAAAGACA---------- ------------AAG--AGAGAATTC---------------------------------- --------TAAAAACAGCAAGAGA---AAAGTATC--------------AAGTCAC---A TAT----------AAGG--------------GAATCCCCAT--TAGACTAA-C--AGCAG ATT--------TCTCAGCAGAA--ACCTTA-CAGG--CCAG-GAGAGAATG--------- ----GGA-TGATATA-T-------TCAAAG--T-GCT-GAAAGAAAAA------------ -AAT-TG--CCA--GCCAAGAA--------TACTAT----------ACCCA--------- --GCAAAGCTATCC-----TTCA-GAAATGA-------AGG-AGAAATAAAGTCTTTCCC AGACAAGC-AAAAACTGAGGGA-ATTCATCACCACTAGAC---CAGCCTTAC-AAGAAAT GCT--------------TAAGGG----------------------AGTCC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TACATCTGGAAAAGAAAAAGGATAATAATCACCATCATGAAAACATTCA AAAGACTACATCTGGAAGTGAAAGGATAATAACTACCATCATGAAAACACA--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CAAAAGTATAAAACTCA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------CTGG---------------------- ------------------------------------------------------------ ---------------TAGAGCAGATGAAAGAGAAA-----------GGAATAAATCTTAT CACTAC------AGAAAACCACC----------------------AAAC-----CACAAA ----GA------TAAACAATAAG--AGAGGA-------AGAAA---------GGAACAAA GGATACAAAACAACCAGAAAACAATTAAC---------------------------A--- ------------------------------------------------AATAACA----- --------------------GGAGTAA--GTCC-TCACCTATCAATAA------------ -------------TAAC-CTTGAATG-TAAATAGATT--AAATTC---CCCAATTAAAAA ATATAGAC--TGGCTGAA-TGGAT-------------TAAAAAAAAAACCCAACTA---- ---TAT-GCTGCCTAAAAGAA-ACTCACTT-TACCT--TTAAAGACACAAATAGACTGAA AG--TAAAGGAA--TGAAAAA-AGATATTCCATATAAAAAG------AAACC-------- -------------AAAAA-AGAACAGGAGAGGAGCTATACTTATATC-AGATAAAATAGA CTTTAAG-TC----------AAAAAATATAAAAAGAGAC-AAAA-AAGGTTATTATAT-- ----AATGATAAA---GGGATCAATTCAGC--AAGAGG--------AT-ATAAAAATTAT AA-----------------ATATATATGCACCCAACACCAGAGCACCCAG--ATATATAA AGCAAATATTATTAGATCTAAAGGGAGAGATAGACTCCAATAC---------AATAATAG TTGGGGACTTCAACACCCCAC-----TCTCAGCATTGGACAGA----------------- ----TCATCTAGAC------AGAA-----AATCAACAAAGAAACATTGGATTTA------ --AACTGCACTATAGACCAAATGGAC-CTAACAG--ACATTTACAGAA--CATTTCATCC AACAGCTG---CAGAATACACATTCTTCTCA-------TCAGCACAT---GGAACATTCT C------CAGGATAGACCATATGTTAGGCCACAAAACAAG-------------------- -TCTCAACAAATTTTTAAAAA--TTAAAAT----------------CATATCAA------ -GTATCTTTTCT---GACCACAATGGAA-TAAAACTAGAAATCAATAACA--------AG A-------------GG-AACTTTG---GAAACTGTACAA----ATACATGGAAATTAAAC AACATG-CTCCTGAA---TG-ACCAATG--GGTCA---ATAAAGAAAT--TAA-AAAGAA AATTAAAAAATTT-------AAAC------------------------AAATGAAAATAG -AAACAAAAC--ATAACAAAACCAA-TGG--ATAAAA-AAAAACAGTACTAAGAGGGAAG --TTTATAGCAATAAAAGCCTACATCAAAAAAG---TAGA--AAGATTT---CAAATAAA ------CAACCTAATGATGCACCTCAA---GGAACTAGAAAA---GC---AAGAACAAAC CAAACCCA-AAATTAGTA------------GAAGGAAAGAAATAAT-AAAGATCAGAGCA GAAATA---AATAAAATAGAGACTAAAAAAA-------AAAAAAAAATA-AACAAAAAAA -AAATT----------TTTTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------C AA-----AA------TCAACAAACTA---TTAGCTA------GACT-------------- ----AACTAAAAAAG---A---GAGA-AGACCCAAATAAA-------------------- -----TAAAA---T---------CAGAAACAAAAAA------GGAGA---CATTACAACT G--------ATAC-CACAGAAATA-CAAAGGATC--ATTAG---------AGACT----- -------------------ATTATGAACAA-CTATATACCAACAA--AT---TGGAAAAC CTAG---AGGAAAT--GGATAAATTCCT--G---GACACA---------TAC-----AAC CTACCA------AGATTGAACCAAGAAGAAATAGAAAACCTGAAC--------------- --------AGACCA------A------TAATAAGTAATAAGAT----TGAAT--CAGTAA -TAAAAAGTCTCCCAACAAAGAAAAG--CC-CAGGACC--AGATGGCTTCACTGCTGAA- TTCTA------------CCAAACATTT----AAAGAAGAACTAATA-CCAATT-----C- ----TTCTCAAACTATTCCAA-------AAAATTA-AAGAGAAGGA-----------AAT TCTTCCAAACTCATTCTACAAG---------GCCAGCAT---TACCCTGATACC--AAAA C-----------------------CAGAC--AAGGACA-CAAC----AA---------AA AAAGAAAACT---------------------ACA------GGCCAATAT--CCC----TG ATGAACATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAA----------AAACCA------------------AA--T------------ ---C-CA--ACA-------------GCACATC---------AAAAAGATTATACA--CCA ----TGAT------------CAAGTGGGA-TTTATCCCAGGGA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATAC----AAATCAATAAATGTG--ATA CATCAC---------A------TCAACAG----AATGAAGGACAAAAAC---CATATGA- ----TCATCTC---AATA----------GATGCAGA-AAAAG---CATTTGATAA---AA TTCAACATCCCTT-------------------CATGA---------T-AAAAAC-TCTCA --ACAAATTAGGTATAGAAGGAATAT-----ACCTCAACACAAT---------------- -----------AAAGGCCAT-ATAT-GACAAACCCACAGC-----------TAACAT--C ATACTGAATGGGGAAAA-G-----CTGAAAGC-TTTT---CCTCTAAGAA----CTGGAA CAAGACAAGGATGC-------CCACTTT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTTTTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATTAG------GCAAGAG---AAAGA--AATAAAGGGC ATCCAAATTGGAAA-------GGAGGAAGTCAAA--TTGTCCCTG-----TTTGCAGATG AC--ATGATCTTA-------TATATAGAAAAACCT---------------AAAGA---CT CCACCA---------AAA--AACTCTTAGAACT---------GATAAA--TAAATTCAGT AAAG--TT-------------------------GCAGGATACAA--------------AA TCAACAT------------ACAAAAAT----CAGTAGCATTTC--TA-TACACCAA--TA ATAAACTAGCTGA------------------AAAAGAAA-TCAAG----AAAGCAATCCC ATTTACAATAGC----------TAAAAAAAAATACCTAGGAATAAATTT--------AAC -CAAGGAGGTGAAAGATCTCT---ACAATGAA--AACTATAAAACACTGATG-AAAGAAA TTGAAGA-----------AG------------------ACAC-AAAAAAAAAATGAAAAA AAAT------C---CCATGTTCATG------GATTGGAAGAATT-----AATA-TTGTT- ------------------------AAAATGACCA-TA-CTACCC-AA------------- ----AGTAATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------ACCAATG- AC------------ATTCTT---------------------------------------- --CACAGAAATAGA--AAA------AAAAAATCCTAAAA-TTTATATGGAA-------CC ACAAAAGACCCC---AAATATAGACAAAGCAATTCTGAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACA---CTACCTGACTTCAAAAT-----ATACTACAA---AGCT ATAGT-AACCAAAAC-AG------CATGGTACTGG--CA-----------------TAAA AACAGACA------CATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAT AAA---TCCATATATTTACA----GCCAAC--TGATTTTT---GACAAA--GGTGC--CA AGAACATAC--ATTGG-----GGAAAGG----ACAGT--------TTCTT--CAATAAA- GGTGCTG----------G-GAAAAC--TGG-A-TATCCA---------------TATGC- AGA---------AAA--ATAAAACTAGACCC-------TCT---------------CTCA CCATATATAAAAAAA-TAAACT-CAAAATGGATTAAAGACTTAAATGTA--AGACCTGAA ACT-AT------------------------GAAACTACTAGAA----------------- ------GAAA--ACATA------G---------GGG---------AAATGCTTCAGGAC- --ATT-----GG-TCTGGGCAAAGATTTTATGGATAA-GACCTCA-AAA----GCACAGG CAACAAAAACAAA----A------AT---AGAC--AAA-TGGGATTAT--AT-------- -------------------------------------------------------C-AAA CTAAAAAGCTT-CTGCA---CAGC-AAAGGAAACAATCAAC-AGAG-TGAAGAG-ACAAC CTGC--AGAA--T-GGGAG--AAAATATTT---GCAAACTATTCAT--------CTGACA AGGGATTAA-------TATCCAGAATATACA--AGGAA--CTCAA--------------- --------------------------------------AAAAAT------------A--- AACAACAAAA-TTAAAA----------AATGGGCAAA-----------TGA--TCTGAAT ---AGACATTTCTCAAAAGAAGACATACAAA--------------TGGCCAAC-AAGTAT ATGAAAAAATG----CTCAACATCACTAA-TCATCAGGGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TATCATCTCACCCCAGTTAGAATGGCTA-- ----TTATCAAAA---AGACAAAAA-----------AAAAAAA--ATG--TTGGT-G--- ---------------AGGATGTAGAGAA-------------------------------- -----AAGGAAACTCTTAT-ACACTGTTTG--TGGGAA---------------------- -------------TGTA-------------AATTA-TAACACCC--------ATTATGA- -------AAAACA-GTATGAAG---TTT-CCCAAAAAACTAAAA--ATAGAACTACCA-- -TATGA--TCCAGCAATCCCACTACTGGG-TATATA-TCCAAAGG-AAA--GGAA----- -------------------ATCAGTAT-ATCAA--AGAGATATCTG----------C--- ---------ACTCC--CATGTTTATTGCAGCACTATT---CACAATA-GCCAAGATAT-G GA--ATCA--ACCTAAG-TGTCCATCA---ACAGATG-----AATGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTATATAT----ACACAATGGAATAC--TATTCA-GCC ATAAAA----------------------AAAAATGAAATTTTGTCATTT----------- ------------------------------------------------------------ -GTGGCAACATGGATGAGC-C---T----------------GGAGGACATTATGTTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGTCA--GGCAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAG---- -----------------------------ATAAATAC-TACATG--------TTC----- ------TCACT---CAT------------------------ATGTGGAAGC---CTAAAA A-------A--------------GTTGAT---------------C--------------- ------------------------------------TCATA-------------GAAG-- -------TA------------------------------------------GAGAGT--- -AGAATAGTGGT---TACTA-----GAGGCTGG----------GAAGGG----------- TAGGGGGGAGGG------------------------------------------------ --GGG-----ATAGGGAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGG---------------------TTG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GTTAATG---------------------------------------------- --------GATA----CAAAATTA------------------------CAGCTAGATAGG AGGAAT--------------------------AAGTTCTAGTGTTCTATAGC-------A CTG-----------------------------------------------------TAGG GTGACTATAGTT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACAATAATT-- ----------------------TATTGTATA--------TTTTCAAATAG---CTAGA-- -------------AGAGAGGATTTTGAATGTTCCCAACACAAAGAAATGATAAA------ ---------------------------------------TGTTTGAGGTGATGGATATGC TAATT-----ACCCTGATT------------------------------TGATCATTACA C-----ATTG-TATACA-------------------------------TGTATC------ ------------------------------------------------------------ ----------------------------------------AAAATATCACTC--TGTACC CCATAAATATGTACAATTA------------TTATGTG----TCAATTAAA------AA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MA5A ---------------------GAGAGTGATGTCAGCAAGATG--GCTGACT-AGAGATGC CTGGCATTCAT-----CCCCCA--------CAAAAAAAGGGC------------------ ---------------------CAAA---------GCAACGAATAAACAG--------CTA AG--ATTTGACTGGA-----GTGTCGAAGGGAGAGTGCTGGAGT-----------GCAGC AGGG---GAGTGGAG-------------------A--------------TGCACCTGTGG TGACT----------------GGAAGTCCAGGAGGGCAGCATGGAGGCACCTGGCCTCTG CAGCCTCATCTCCCCCACCTG-----------------GATCAGATTGGCCTAGAGTCA- --------------GGAGGGACTTCCCAT---------------TGT-----GG-GGAAA AGGTAAGCAG---------------------------AAGATCC-CCACCAGCCCCCATT G-------------------------CCACTGCAAACACCTACAGTCCTT----ACTACA GGAGAATCCCACAGTCCT---CAC------------------------------------ ---A---------AGCCCTGAGCCCAGTTTGG------------------AGAGCTGCCG GGAATTCATGCAGCTGCATTG---------CCCCAGATTAGGAGCACAAGGTGTG----- ------------CACTCCCCCCACCCCCACCCACCCCCTGTGAGCCAAGCTGCTG----- ---------------------------CAGCATGGTGCCATCTTGAGACCAGAGCCACCT CTGGAGTGC--------------------------------ACCCTGCTCTGGGGGCCAG TAGCCACTGCACCT-CTCCAGCACTGGGGCTCCATCTTCATTCCAC-------------- ---CAAGCCCACACAGGTGGCTGAATGCCA------------------------------ ------------------------------------CAACCCCAGCTGTGCGGAGCCTGG GCCCAGGA-----------TTGGCTGTGACTCTGGTCCTGCACATC-------------- ---------------AGGGAA-------------------ACCAACCCCTGCC------- ---------------------------------------------------------TCC CCCACCTTCCAGCAAGAGAAACGGTTTGC--------------CGTTCCACCCAGG---- -------------------GCAAACCCACCCTTGA----------------GCCAGCCAA AC-------------TAC------------------------------------------ -------TGTGTG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------CCCTCCCCCGAGCAGGAGAGGTCCCCAAGCCACCAAGCAGCT GACATGCCCCC------------------------------------------------- --------------------------------------AGGCCAGCC--------GAGTG GCTATGTGCCCATGCCCAGGGCCTGAGAAACAGCCC------------------------ ------------------------------------------------------------ -----------------------------------------------------CGTGGGT CCCCCCCGGCAAACAGAC--------------CCCCAGGCCAGCTGA------------G CAGCTGTGC------ACCCACA--TCCCAGGCCTGAAAA--------------------- -----------ACAGCCCCATGG--------------GCCCCCCCCAGTGGACACGCCCC CAG--GCCAGCCAAGCAGCCTTGTACCCACATCCTGGGCCTGAGAAACAGCCCTGTGGGC CAATATGCCCACAGGTTGGACGAGCAGCTATATGG---------------------CCAT GTCCCAGGTCC---AAAAGAGTC------------------------------------C TGTGGGCCAC--CACCCA------------------------------------------ -------------------------------------CAGAAACGCCCCAAACCAGCCAA GCAACTGTGCAGTTATATCGTGGGCCTGACAAACAGCCCTGT------------------ ------ACCCACCCATGGTAGCCATGCCCACCCAGGCTGGTCAGG--------------- ----------------------------------------------CCACTGCATGCCCA TGTCTCAAGCTGGAGAAATGGCCTTGG----------------------------TAGGA TGCCCTCCCCCCCGGCCAATTGAG------------------CACTGCTGTGTTTCATAG GCCCATGTC----------TCATGCCTAAGAACCCGTCTCACAGGCAACCC--------- ------------CCGGC------------------------------AGACACACCCCCA GGCCA-------------GCCGA---------GCAG------------------------ ---------------------------------------------CCTTGTGCCTGTG-- -------TCCTGGGCCTGA----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAAACAGCCCTATGGGCTGC-----------------CCC T-----------GGCAGACATGCCCCC--------------------------------- ------------------------------------------------------------ ----------------------------------------AGGCCAGCCGAGCAGC---- ------------------------------------------------------------ -----------TGTGTGCC----------------------------------------- ------------------------------------------------------------ --CGCATCCT-AGGCCTGA--------------G-------------------------- ------------------------------------------------------------ ---------------------------------AAACAGTCCTA---------------- ------TGAGCTGCTCCTGGCAGGAAACCCCTCA-----GGCTGGCCAAGCAACCACA-T GCCCATGCTCCTA--------------------GCCAGAGTAACAGCCCT---------- GTGGCCCCAAC----CCCA-------GCG-AGCCAGACCC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TAA-GTTGGCTG ACCCATCATGTGCATGCA------CGTGC------------CCCCGACC----------T GAGAAAC---AGCCCAGTGAGCCCACCCCTGGCAAAGC---------------------- ---------------------------------CACACCACTGCCACCACAAATT----- ----------------------------------------CTCTCAGCCTAGGCCACTGA GACACTCACAAATGTCACTAGTGTG---GATTACAGCTG--------------------- ----------------------AAGAA-------------ACTA------CATGGAGACT ----------------------ACACTACTGCATCCACCTAGAACCAAAG---------- -----CCAACACACC--------------------------------------------- ------------------------CCAC-CAAAC---TGACACCCC-----AAGACCCAT CTATACGAATAAGTCTTTCCCTACAAAACCTACTCCATAAAA------------------ --------------------------------------------TTGGAAGAGGTGACTT TTCCACCAGC--AAGC------------------AGAAG---------AAA--AAT-TTC AGAACTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGATAGATCTTTTGAAA-T--AACACAA-------------------ACAC--- ------------------TGGCAAAAAAAAA---------AAAAAAAAAAA--------- TGA-AAAAAAGCTACAG--GA--------------------------------------- -----------TTTTTGG--TGTTCCACAAG--------------GAAAAGAAAAGAATA AAGGTAA---AG---------AAAACATATTTAA--T--------GAAATAATAGC-T-G AAAACTTCCCAAGTCT--------------------TGGGAGAGAGATGG--ACATCCAG ATCC-----AGGAAGCTCAAAGAAC---CCCAAA-TAGAT--------TCA--------- ---A-CCCAAAAA-----GGTCCTCTCCAA----------------------------GG CACATTATAGTCAAATT------GTC-AAAAG---------TCAAAGACA---------- ------------AAG--AAAAAC------------------------------------- --------TAAAAACAGCAAGAGA---AAAGCATC--------------AAGTCAC---A TAT----------AAGG--------------GAATCCCCAT--TAGACTAA-C--AGTGG ATT--------TCTCAGCAGAA--ACCTTA-CAGAGCCCAA-GAGAGAATG--------- ----GTA-TGATATA---------TAAAAA--A-GAC-AAAAAAAAAA------------ -AAC-TGTCTCC--GACAAGAA--------TATTAT----------ACCCA--------- --GCAAAGCTATCC-----TTCA-GAAATGA-------AGG-AGAAATAAAATCTTTCAC AGACAAGC-AAAAACTAAGGGA-ATTCATCACCACTAGAC---TAGCCTTAC-AAGAAAT GCT--------------CAAAGG----------------------AGTCA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TACAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------CTGG---------------------- ------------------------------------------------AAATAAAACTCA CTGGTAGAGCCAATACACAAAGGAGAAAGAGAAAG-----------GAATCAAACCTTAT CACTAC------AGAAAACCACC------C----------------AAC-----CACAAA ----AA------TAAACAATAAG--AGAGGA-------AGTAAGG-------AACAAAGG ATATACAAAACAACCAGAAAACAATCAAT---------------------------A--- ------------------------------------------------AATGACA----- --------------------GGAGTAA--GTCC-TCACCTATCAATAA------------ -------------TAAC-CTTGAATG-TAAATAGATT--AAATTC---CCCATTTAAAAG ATATAGAC--TGGCTGAA-TGGATTAAAAAAATAAAAAAAAAAAAAGACCCAACTA---- ---TAT-GCTGCCTACAAGAA-ACTCACAT-CACCT--GTAAAGACACACATAGACTGAA AG--TGAAGGGA--TGGAAAA-AAAATTTTCAATCAAAAAG------AAAAC-------- -------------AAAAA-GAAGCAG--GAGTAGCTATACTTATATC-AGACAAAACAGA CTTCAAG-TC----------AAAAACTGTAAAAAGAGAC-AAAG-AAGGACATTATAT-- ----AATAATAAA---GGGATCAATTCAGC--AAGAGA--------AT-ATAACAATTGT AA-----------------ATATATATGCACCCAACACCGGAGCACCCAG--ATATATAA AGCAAATATTATTAGATCTAAAGGGAGAAATAGACCCCAATAC---------AATAATAG TTGGGGACTTCAACACCCCAC-----TCTCAGCATTGGACAGA----------------- ----TCATCTAGAC------AGAA-----AATCAACAAAGAAACATTAGATTTA------ --AACTGCACCATAGACCAAATGGAC-CTAACAG--ACATTTACAGAA--CATTTCACCC AACAGCTG---CAGAATACACATTCTTTTCA-------TCAGCACAT---GGAACATTCT C------CAGGATTGACCATATGTTAGGACACAAAACAAG-------------------- -TCTCAAAAAATTTTTAAAAA--TTAAAAT----------------TATATCAA------ -GTATCTTATCT---GACCACAATGGAA-TAAAACTAGAAATCAATAACA--------AG A-------------GA-AACATTC---GAAACTATACAA----ATACATGGAAATTAAAC AACATG-CTCCTGAA---TG-ACCAATG--GGTGA---AGGAAGAAAT--TAA-GAATGA AATTTAAAAATTCCTT---GAAAC------------------------AAATGAAAATAG -AAACACAAC--ATACCAAAACCTA-TGG-GACACAGCAAAAGCAGTATTAAGAGGCAAG --TTTATAGCAATAAATGCCTACATCAAAAAAC---TAGA--AAGATTT---CAAATAAA ------CAACCTAATAATGCACCTCAA---AGAACTAGAAAA---GC---AAGAACAAAC CAAACCCA-AAATTAGTA------------GAAGGAAAGAAATAAT-AAAGATCAGAGCA GAAATA---AACAAAATTGAGACTAAAAAAA-------TACAAAAGATC-AATGAAACAA -AAAGT-------TGGTTTTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGACAAACCA---TTAGCTA------GACT-------------- ----AAGAAAAAAAA---A---AAGAGAGAAACAAATAAA-------------------- -----TAAAA---T---------CAGAAATGAAAAA------GGAGA---CATCACAATA G--------ATAC-CACAGAAATA-CAAAGGATC--ATTAG---------AGACT----- -------------------ACTATGAACAA-CTATATACCAATAA--AT---TTGAAAAC CTAG---AGGAAAT--GGATAAATTCCT--G---GACACA---------TAC-----AAC CTACCA------AGATTGAACCAAGAAGAAATAGAAAACCTGAAC--------------- --------AGACCA------A------TAACAAGTAATAAGAT----TGAAT--CAGTAA -TAAAAAGTCTTCCAACAAAGAAAAG--TC-CAGGACT--GGATGGCTTCACTGCTGAA- TTCTA------------CCAAACCTTT----AAAGAAGAATTAATA-CCAATT-----C- ----TTCTCAAACTATTCCAA-------AAAATTG-AAGCGGAGAA-----------AAT TCTTCCTAACTCATTCTATGAG---------GCCAGCAT---AACCCTGATACC--AAAA C-----------------------CAGAC--AAGGACA-CAAC----AA---------AA AAAAAAAACT---------------------ACA------GGCCAATAT--CCC----TG ATGAACATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACCA------------------AA--T------------ ---C-CA--ACA-------------ACACATC---------AAAAAGATAATACA--CCA ----TGAT------------CAAGTGGGA-TTTATCCCAGGAA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATGC----AAATCAATAAATGTG--ATA CATCAC---------A------TCAACAG----AATGAAGGACAAAAAC---CATATGA- ----TCATCTC---AATA----------GATGCAGA-AAAAG---CATTTGATAA---AA TTCAACATCCCTT-------------------CATGA---------T-AAAAAC-TCTCA --ATAAATTAGGTATAGAAGGAAAGT-----ACCTCAACACAAT---------------- -----------AAAGGCCAT-ATAT-GACAAACCCACAGC-----------TAACAT--C ATACTGAATGGGGAAAA-G-----CTGAAAGC-TTTT---CCTCTAAGAA----CTGGAA CAAGACAAGGATGC-------CCACTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCTTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATTAG------GCAAGAG---AAAGA--AATAAAGGGC ATCCAAATTGGAAA-------GGAGGAAGTCAAA--TTGTCCCTG-----TTTGCAGATG AC--ATGATCTTA-------TATATAGAAAAACCT---------------AAAGA---CT CTACCA---------AAA--AACTCTTAGAACT---------GATAAA--TAAATTCAGT AAAG--TT-------------------------GCAGGATACAA--------------AA TCAACAT------------ACAAAAAT----CAGTAGCATTTC--TA-TACACAAA--CA ACAAACTAGCTGA------------------AAAAGAAA-TCAAG----AAGGCAATCCC ATTTACAATAGC-TACAAA---AAAAATAAAATACCTAGGAATAAATTT--------AAC -CAAGGAGGTGAAAGACCTCT---ACAAGGAA--AACTACAAAACACTGATG-AAAGAAA TTGAAGA-----------GG------------------ATAC--AAAT--AAATGGAAAG ACAT------C---CCATGCTCATG------GATTGGAAGAATT-----AATA-TTGTT- ------------------------AAAATGACCA-TA-CTACCC-AA------------- ----AGCAATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------ACCAATG- AC------------ATTCTT---------------------------------------- --CACAGAAATAG---AAA------AAAATATTCTAAAA-TTTATTTGGAA-------AC AAAAAAAACCCC---AA--ATAGCCAAAGCAATCCTGAGCAAAAAGAAAA---AAGC--T -------GAAGGCATCACA---CTACAAGACTTCAAAAT-----ACA---------AACT ATAGT-AAACAAAACTAG------AAGGCAACTGGCACA-----------------TAAA AACAGACA------CATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAT TAA---TCCACATATCTACA----GCCAAC--TGATTTTT---GACAAA--GATGC--CA AGAACACTC--ATTGG-----GGAAAGG----ACAAT--------CTCTT--CAATAAAT GGTGCTG----------G-GAAAAC--TGG-A-TATCCA---------------AATGC- AGA---------AAA--ATAAAACTAGAACCCC----CACT---------------CTCA CC--CTATAAAAAAA-TCAACT-CAAAATGGATCAAAGACCTAAATGTA--AGACCTGAA ACT-AT------------------------AAAACTACTAGAA----------------- ------GAAA--ATATA------G---------GGG---------AAATGCTTCAGGAC- --ATT-----GG-TCTGGGAAAAGATTTTATGAATAA-GACCTCA-AAA----GCACAGG CAACAAAAGCAAA----A------AT---AAAC--AAA-TGGGATTAT--AT-------- -------------------------------------------------------T-AAA CTAAAAAACTT-CCGCA---CAGCAAAAGAAAACAATCAAC-AGAG-TAAAAAG-ACAAC CTAC--AAAAAAT-GGGAG--AAAATATTT---GCAAACTATTCAT--------CTAACA GGGGATTAA-------TATCCAGAATATACA--AGGAA--CTCAA-----ACATC----- ----------------------TCAACAGCAA------AAAAAA------------A--- AAAAATCTTA-TTAAAA----------AATGGGCAAA-----------TGA--TCTGAAT ---AGACATTTCTCAAAAGAAGACATACAAA--------------TGGCCAAC-AAATAT ATGAAAAAATG----CTCAACATCACTAA-TCATCAGGGA-AAT--GCAAATC-AAAACC ACAATGAGG---------------------TATCATCTCACCCCAGTTAGGATGGCTA-- ----TTATCAAAA---AGACAAAAA-----------AAAAAA---ATG--CTGGT-G--- ---------------AGGGTGCGGAGAA-------------------------------- -----AAGGGAACTTTTTT-AAACCGTTGG--TGGGAA---------------------- -------------ATTAA------------AACTA-GTAAAGCC--------ACTATGG- -------AGAACA-GTATGGAG--GTTC-CTCAAAAAACTACAA--ATAGAACTACCA-- -TATGA--TCCAGCAATCCCACTACTGGG-CATTTA-TCCAAAGGAAAG--GAAA----- -------------------ATAAGTAT-ATTAA--AGAGACATCTG----------C--- ---------ACCCC--CATGTTTATTGCAGCACTATT---CACAATA-GCCAAGATAT-A GAGTATAA--CCCTAGG-TGTCCAACA---ACGGATG-----AATGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTATATAT----ACACAATGGAATAC--TATTCA-GCC ATAAAA----------------------AAGAATGAAATCCTGTCATTT----------- ------------------------------------------------------------ -GTAGCAACATGGATGGAA-C---T----------------GGAGGACATTATGTTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GGAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAG---- -----------------------------TTAAACAC-TGCATG--------TTC----- ------TCACT---CAT------------------------ATGTGGA------CTAAAA AA------A--------------GTTGAT---------------C--------------- ------------------------------------TCATA-------------GAAG-- -------TA------------------------------------------AAAAGT--- -AGAACAGAGGA---TACTA-----GAGGCTGGG---------AAGGGT----------- AGGGGGAAGGGG------------------------------------------------ --GGG-----ATAGGGAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGA---------------------TTT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GTTAAAG---------------------------------------------- --------GATA----CAAAATTA------------------------CAGCTAGATAGG AGGAAT--------------AAGTTCTAGTGT------------TCTATACC-------A CTG-----------------------------------------------------TAGG ATGACTATAGTT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACAATAA---- -------------------------TATATA--------GTTTCAAATAG---CTAGA-- --------------AGGAGGATATTGAATGTTCCCAACAC-----AAAGAAATGATAAAT GTTT----------------------------------------GAGATGATGGATATGC TAATT-----ACCCTGATC----------------------------------------- -TGATCACTA-TACATTATA----------------------------TGTATC------ ------------------------------------------------------------ ----------------------------------------GAAACATCACTA--TGTACC CCATAAATATGTACAATTA------------TTATGTG----TCAATTTAA------AA- -------AA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MA8 ----------------------------CAGGCTCCAGGTCTTCCCAGTGCCAGGCTTGT CTCTATGTCTT---TACCCTC--------------------------------------- ---------------------CAAA---------CCAGTCCTTACACCC--------TAG TG--TTCCAGCAG-A--------------------------------------------- -------------------------------------------------CTCATAGTTCA AGT-------------------AAGTCCCAGTAGACCCAAGCACTG-------------- --------------------------------------------------GAGAAGCCAG TCCCC--------AGGCTTTCCCTCCAGGT----CCCAGGACTTTCC-----CT------ ---------------------------------------TTGTG-CCCAGGTTCCAGGTC A-------------------------GCCCCTGAGGCCCTAAGAACCAGG-CCACCCTCA GGGACTTAACCTCTCGGTAAGTCC------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GTACAGAAC------------------------------------ ---------------------CATCCTCTAGT---------------------------- ------------------------------------CAGCC------------------- -------------------CCCACTGGAAGACCGATTTAGACAGATATGTGTGCACAAAG ATTCCTGGGCAACCCATAAAAGAACCAGGTGAATGACAACAATAATTGATCATGAGG--- ------------------------------------------------------------ -------ATCTGTCAAAGAACTCGGCAAT--------------ATGTTGGGCCAGT---- ----------------GGTGCAGGTCATGTTACAT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------TACTCCTCGCTCCCTAGG---------------ATCAATAGTGA GGAGTAAACCC------------------------------------------------- -----------------------------------AGGAGACCGGAA------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ TTCTTGACTTAAGGAAAAAACAGGG----------------------------------- ---------------TTCAGAG--GGACAACTTTGACGA--------------------- ---------TTAAGTCCACAAGG---------------------------ATGCAGCCCT CGG---------------------CAAAGTCCCTCGGTACCTGCCAGCGG---------- ------------TGTCCGC--------TTCCTCC----------------------CCGG GTCCGC---CC---CAGGCTCGC------------CTCTCGTG---------------AC TCACTCACAA--GAACCATGCCTCCGACAGGCCCGGCG---------------------- -------------------------------------CTATCAACCCAG----------- -----GCTTCAGGGTGGCCTCTATACACTCAGCCACTCAGTC------------------ ------CGTTCTTATGGGACAAGGCG---------------------------------- ------------------------------------------------------------ -----------GAAGGCCGACACCG------------------------------CTGCA ACCCCA------------------------------------------GACTACGCCTCC CCCCGCACA----------TCCAGTATCTACTCCCAACCCTAGGACCTCCA--------- -----------------------------------------GCTCCCTGCTCCTCCACCT GCCAA----------CGCACCCAGCTGCACGGACTG------------------------ ----------------------------------------------CCCAAGGTCTCAAA C-----------GGCGCGCCCGCTC----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------ATGGCAC------------------------------AGC C-----------CATATGCCCTACCCAGCATGTCCCGACCGGCTGA-------------- ------------------------------------------------------------ --------------------------------CTGGTAAAGGAATTTCCCCG-------- ------------------------------------------------------------ -----------ACAAAGCC----------------------------------------- ------------------------------------------------------------ --AGCCCGTGAAGTCTAGA----------------------------------------- ---AGAGGTCCTTACTTCTTC--------------------------------------- ----------------------------------AAATGCATAG---------------- ------ACATCAAT-------CTAGGGCAACA-------AGAAACAGGAAAAACAAGGAA AGCGTGACAACAC-----CAA------------AAGAATAAAATAATCCA---------- CCATTGGCGACCCTCTAAA----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TATAGATATATA AACT------GCCTGACA------CAGGA------------TTCAAAAT---AATTGG-T TTAGGGA---AGCTCAGTGAACT----ACAGGAAAAAAAATTAAAAAATTTCAGAAAGAT AAGAAAAAAATAACTGGACAAAGTGAAATATTTAAAAAAAAG-----AAAGAAAT----- ----------------------------------------A-------------AAAAAA AACAAAAATAAAACTTGAAGAAGTA---GAAGAAAAATA--------------------- ----------------------ATAAAAATTTATTAAGAAAAGA------AATAACAAAA --------------------------------------AAAAAGAAGAAA---TGGAAAA GACAATGAAAGGATCAAAAAGAAAAAAGAATGAATCATTGAGGACAAAAAAGGTAGAGTT TAATAAACATGAGAAGAGAAAAAGGAAA-AGAAA---TAAAA---------AAAAGTAAA AAAAGAACAAATAGTTTATGTAACACAGTAT-------AAAGAGCAAATGTATGAGTTGT TGGAGTTAAAGAGGGAGAGGAGAAAAACAAAGGGGCAAATATATCATTGACAGCAAAGT- -----TGATC--AAAC------------------AGAAG---------AAAG-AAT-CTG TGAACTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACACATTATTTAAAAAT---------------ATAG---------CGAG--- ------------------GATTAAAAAGAAA--AAGA---ATAAAAAGGAA--------- TAA-AAAAACTTTCAGG--AACTTATGGGAACAGCATC-----------AAAAG--AGCA ATTGTTTGAG-TTATAAG--TGTTTAAATAGTTATCAATTTATAGGGAAAAAAAAAAAAG AAAAGGGGGTAG---------AAAGCTTATTTAA--A--------GAAATAATAGC-A-G AAAACTTTCCAAATCT--------------------GGAGAAAGATATAA--ATATCCAG GTAC-----AGGAAGGTCAAAGGTC---TCCAAT-CAGAT--------TCA--------- ---A-TCCAAACA-----AGACTACACCAA----------------------------GA CATATTATAATCAAATT------GTC-AAAAA---------TCAAAGACA---------- ------------AAG--AGAAAATCT---------------------------------- --------TGAAAGCAGCAAGAGA---AAAGAAGC--------------AAATAAC---A TAT----------AAGG--------------GAGTTCCAAT--AAGGCTAA-C--AGCAA ATT--------TTTCAGCAGAA--AACTTA-CAGG--CCAG-GAGAGAGTG--------- ----GGA-TGATATA-T-------TCAAAG--T-GCT-GAAGGAAAAA------------ -AAT-TG--CCA--ACCAAGAA--------TACTGT----------ACCCA--------- --GCAAAGTTGTCC-----TTCA-GAAATGA-------AGG-AGAAATAAAGACTTTCCC AGACAAAC-AAAAGCTGAGGGA-GTTCATCACCACCAGAC---CTGTCTTAC-AAGAAAT GCT--------------AAAGGG----------------------AGTTC---------- ------------------------------------------------------------ ------------------------------------------------------------ --TTCAAGCTGAAAGAGAAAGGAGGCAAGTTAGCAAATTAGTAACACAAAAACATATGAA AATATAAAACTCACTGG------------------------------------------- -----------TAAAA--------------GTAAGTACACGGCCAAATTGAATACTCTAA TACTGTAATGGTGGTGTGTAAATCACTTATATCT---TTAGTATGAAGGTT--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AAAAGACAAAACTATTAAAAA TAATAAAGGCAAAATTAATTTGTTAGGGCATACATAATTTACA----------------- -------------GGAACAGCTACAGTGAATTCCTCAATCTATAATAATTTGTTAAGAGA TATACAATATAAAAAGATGTAAATTGTGACATCAAAAACATAAAATGTGGGGGGGGGGGT GGAAAGAAAAGGTAG--------------------------------------------- ------------------------------AGATTTTAGAATGTAAGGCATAAAGTGTAG AGTTTTTTTATGTAATCAAAGTTAAGTTGTTATCAGCTTAAA------------------ ----------------------------------ATAG-------------CCTGTTATA ACTATAAGATGTTTTATGTAAGCCTCATGGTAACCACAAAGCAAAAACCTATAGTAG--- ------------ATACACAAAAGATAAAAAGTAAG-----------GAATCAACAC--AC CACTAG------AGAAAATCACC----------------------TAAT-----CACAAA ----GG------AAGACAGCAAG--AGAGGA-------AGAAAGAAA-----AAAAAAAG ATCCACAAAACAACCAGAAAACAATTAAC---------------------------A--- ------------------------------------------------------A----- --------------------ATAGTAA--ATCC-TTACCTATCATTAA------------ -------------TTAC-CTTGAATG-TAAATGGATT--AAATTC---TCCAATCAAAAG ACATAGAG--TGGCTGAA-TGGAT------------TAAAAAAAAAAAACCAAAAT---- ---TAT-ACTCCCTACAAGAG-ACTCACTT-CACAT--TTAAGGACACACATAGACTGAA AG--TGAAGGGA--TGGAAAA-AAATATTCCATGCAAATAG------AAACC-------- -------------AAAAG-AGAGCAG--GAGTAGCTATACTTATATC-AGATAAAATAGA CTTTAAG-TC----------AAAAACTGTAAAAAGAGAC-AAAG-AAGGTCATTATAT-- ----AATAATAAA---GGGATCAATTCATC--AAGAAG--------AT-ATAACAATTAT AA-----------------ATATATATGCACCCAACATTAGAGCACCTAA--ATATATAA AGCAAATATTAATAGATCTGAAGGGAGAGATAGACTGCAATAC---------AATAATAG TAGGGGACTTTAATAACCCAC-----TTTCAACAATGGACAGA----------------- ----TCATCCAGAC------AGAA-----AATCAATAAGGAAACATTAGACTTA------ --AACTACACTTTAGACCAAATGGAC-CTAACAG--ACATATACAGAA--CATTCCATCC AACAGCTG---CAGAATACACATTCTTCTCA-------ACTGCACAT---GGAACATTCT C------CAGGATAGATCATATGTTAGGCCACAAAACAAG-------------------- -TCTTAACAAATTTAAGAAGA--TTGAAAT----------------TATATCAA------ -GTATCTTTTCT---GACCACAATGGTA-TAAAACTAGAAATCAATAACA--------GG A-------------GG-AATTTTA---GAAAATTCACAA----ATACATGGAAATTAAAC AACATG-CTCCTGAA---CA-ACCAATG--GGTCA---AAAAAAAAAT--TAA-AAGGAA AATTAAAAAATTTCTT---GAGAC------------------------AAAAAAAAATGG -AAACACAAC--ATACCAAAACTTA-TGG-GATACAGCAAAAGCAGTTCTAAGAGGGAAG --TTTATAGCAATAAATACCTACATAAAAAAAA---AAAA--AAAAAAT---CAAATAAA ------CAACCTAATATTACACCTCAA---GGAACTAGAAAA---AG---AAGAACAAAC TAAGCCCA-AAGTTAGTA------------GAAGGAAGGAAATAAT-AAAGATCAGAGCA GAAATA---AATGAAATAGAGACTAGAAAAA-CAA---TAGAAAAAATC-AAAAAAACTA -AGAGT-------TGGTTTTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTAACAAACCT---TTAGCTA------GACT-------------- AAGAAAAAAAAAA---------AAAA-AGACTCAAATAAA-------------------- -----TAAAA---T---------CAGAAATGAAAAA------GGAGA---CATTACAACT G--------ATAC-CACAGAAATA-CAAAAGATC--ATAAG---------AGACT----- -------------------ATTATGAACAA-TTATATACCAACAA--AT---TGGATAAC CTAG---AAGAAAT--GGATAAATTCCT--A---GACACA---------TAC-----AAC CTACCA------AGACTGAATTATGAAGAAATAGAAAATCTGAAC--------------- --------AGACCA------A------TAATAAGTAAGGAGAT----TGAAT--CAGTAA -TAAAAAGTCTCCCATCAAAGAAAAG--CC-CAGGACC--TGATGGCTTCACTGCTGAA- TTCTA------------CCAAACATTT----AAAGAAGAACTAATA-CCAATT-----C- ----TTCTCAAACTCTTCCAA-------AAAATTG-AAGAGGAGGG-----------AAT ACTTCCAAACTCATTTTACAAG---------GCCAGCAT---TACCCTGATACC--AAAG C-----------------------CAGAC--AAGGACA-CTAC----AA---------AA AAAAAAAATT---------------------ACA------GGCCAATAT--CCC----TG ATGAACATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACCA------------------AA--T------------ ---T-CA--ACA-------------GCACATT---------AAAAAAATCATTCA--CCA ----TGAT------------CAAGTGGGA-TTTATCCCAGGGA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATGC----AAATCAATAAATGTG--ATA CATCAC---------A------TTAACAG----AATGAAGGACAAAAAC---CATATGA- ----TCATTTC---AATA----------GATGCAGA-AAAAG---CATTTGACAA---AA TTCAACATCCTTT-------------------CATGA---------T-AAAAAC-TCTCA --ACAAATTAGGTATAGAAGGAATGT-----ACCTCAACACAAT---------------- -----------AAAGGCCAT-ATAT-GACAAACCCACAGC-----------TAACAT--C ATACTCAATGGGGAAAA-G-----TTGAAAGC-TTTT---CCTCTAAGAT----CTGGAA CAAGACAAGGATGC-------CCACTCT-------------------------------- ------------------------------------------------------------ ------------------------TACCACTTCTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATTAG------GCAAGAG---AAAGA--AATAAAAGGC ATCCAAATTGGAAA-------GGAAGAAGTTAAA--TTGTCTCTG-----TTTGCAGATG AC--ATGATCTTA-------TATATAGAAAACCCT---------------AAAGA---CT CCACCA---------AAA--AACTGTTAGAACT---------AATAAA--TAAATTCAGT AAAG--TT-------------------------GCAGGATACAA--------------AA TCAACAT------------ACAAAAAT----CAGTAGTATTTC--TA-TACACTAA--CA ACAAACTATCTAA------------------AAAAGAAA-TCAAG----AAAACAATCCC ATTTATAATAAC-TACAAA------AATAAAATACTTAGGAATAAATTT--------AAC -CAAGGAGGTGAAAGATCTGT---ACACTGAA--AACTATAAAACATTGATG-AAAGAAA TTGAAGA-----------AG------------------ACAC--------AAATAAAAAG ATAT------T---CTATGTTTATT------GATTGGAAGAATT----AAATT-TTGTT- ------------------------AAAATTTCCA-TA-TTACCC-AA------------- ----AGTGATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------TCCAATG- AC------------ATTTTT---------------------------------------- --CACAGAAATAG---AAA------AAAAAATTCTAAAA-TTTTTATGGAA-------CC AAAAAACCCCCA---AA--ATAGCCAAAGCAATCTTGAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACA---CTACCTGACTTCAAAAT-----ATACTACAA---AGCT ATAGT-AATCAAAAC-AG------CATGGTACTGG--CA-----------------TAAA AACAGACA------CATAGAC--CAATGGAACAGAATAGAGAGCCC------AG--AAAT AAA---TCCACACATTTATA----GTCAAC--TGATTTTT---GACAAA--GGTGC--CA AGAACACACACAATGG-----AGAAAGG----AGAAT--------CTCTT--CAATAAAT GGTGTTG----------G-GAAAACTATAT-A-TATACA---------------CATGC- AAA---------AAA--ATAAAATTAGACCTTT----ATTT---------------CACA CAAAATA----AAAAATTAACT-CAAAATGGATTAAAGACTTAAATGTA--AGACCTGAA ACT-AT------------------------AAAACTACTAGAA----------------- ------GAAA--ACATA------G---------GGG---------AAAAGCTCCATGAC- --ATT-----GG-TCTGGGCAATGATTTTTTGGATAT-GACCCCA-AAA----GCACAGG CAAAAAAAGCAAA----A------AT---AGAC--AAA-TGGGATTAC--AT-------- -------------------------------------------------------C-AAA CTAAAAAGCTT-CTGCA---CAGC-AAAGGAAACAATCAAC-AGAG-TGAAGAG-ACAAC CTAA--GAAA--T-GGGAG--AAAATATTT---GCAAACCATACAT--------CTGATA AGGGGTTAA-------TATCCAAAATATATA--AGGAA--CTCAA-----ACAAC----- ----------------------TCAATAGCAA------AAAAAC------------A--- AATAACCTAA-TTAAAA----------AATGGGCAAA-----------AGA--CCTGAAT ---AGACATTTTTCAAAAGAAGACATACAAA--------------TGGCCAAC-AGGTAT ATGAAAAAATG----CTCAACATCACTAA-TCATCAGGGA-AAT--GCAAATT-AAAACC ACAATGAGA---------------------TATCACCTCACACCTGTTAGAATGGCTA-- ----TTATCAAAA---AGACAAAAG-----------ATAACAA--ATGTTTTGGA-G--- ---------------AGGATGGGGAAAA-------------------------------- -----AAGAAAACTTTTAA-ACACTTTGGG--GGGAAA---------------------- -------------TGTAAA-----------AATTA-GTACAGCC--------ATTATGA- -------AAAAAA-GTATGAAG---TTT-CTTAAAAAATTAAAA--ATAGAACTACCA-- -TATGA--TCCAGCAATCCCACTACTGGG-TATATT-TTCAAAAGAAAT--TAAA----- -------------------ATCAGTAT-TTTGA--AAAGATATATC----------C--- ---------GCTCT--CATGTTTATTGC-GCAATATTTTACAAAATA-GCAAATATAT-G GA--ATCA--ACCTAAG-TGTCCATCA---ATAGATG-----AATGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTATATAT----ACACAATGGAATAC--TATTCA-GCC ATAAAA----------------------AAGAAGAAAATCCTGTCATTT----------- ------------------------------------------------------------ -GCAACAACATGGATGAAC-C---T----------------GGAGGACATTATGTTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GGCAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAG---- -----------------------------ACAAATAC-TACATG--------ATC----- ------TCACT---TAT------------------------ATATGGAAAT---CTAAAA A----------------------GTTGAA---------------C--------------- ------------------------------------TCATA-------------GAAG-- -------CA------------------------------------------GAGAGT--- -AGAATGGTGGT---TACCA-----GGGGCTGGG---------GGGGGG----------- ----------GG------------------------------------------------ --GGG-----TTGGGGAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------ATG---------------------TTG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GTCAAAG---------------------------------------------- --------GATA----CAAAATTT------------------------CAGTTAGACAGG AGGAAT--------------------------AAGTTCAAGAGATCTATTGT-------A CAA-----------------------------------------------------CATG GTGACTATAG-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TTTAACAATG-- ----------------------TATTGTATT--------CTTGAAAATTG---CTAAG-- --------------AGAGTAGATTTTAGTGTTCTCACCACAAAAAAGATAAG-------- ---------------------------------------TATGTGAGGTAATGCATATGT TAATT-----AGCTTGATT------------------------------TAGCCATTCCA C-----AATG-TATACA-------------------------------TATTTC------ ------------------------------------------------------------ ----------------------------------------AAAACAT--CATGTTGTACA CCATAAATATATACAATTT------------TTATTTG----TCAATTAAA------AA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MA7 ------------------TCCACTGCTCCTGATTCCAGGCCAGTGCCCATGGAGGAAGAA TTCAGACCTGC-------CCC--------------------------------------- ---------------------AGGC---------CAGACGGAAATCTGC--------TAC CC--TATCAGGAGAAACCTGAGTACAAGTCCCCTTTAACAACAG-----------CTGAC TGAA---GTGGCCTTGGGCCCCGCCCTGAATAAAT--------------TTCAGTGGTAG C--------------------CAAGCTATAGCAATCATGGTCCTTG-------------- --------------------------------------GGTAAACC--CCAGTGATGCAC TGTTCT-------GGGAGGCTGTGGGCTTG----TGGTATGACCCAG-----AGTGATAC CAGCTGTGGAGGTCAT------GGGAGTGCTCTTGTCACCTCTT-CCCCAACACCAGGCA G---------------------------------------TGCAGT--------GTGGAG ACAGAATCCTTCTACTCT------------------------------------------ --------------------------------------------------GAATAAGGAG AGGAAAAAGTAGAAGGGACCA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GCCCCGCCCACCACAGAACAATGCAGCCAACCAAAT------------------- ----------CCTGGGGCTATCCTTAGC-------------------------------- ------------------------------------------------------------ -------------------CACATAGCCGACCCAGTGTCATGTCCCTAG----------- ----------------------------------------AAGTGACTTTCCTCTGA--- ------------------------------------------------------------ -------------------------CGGG--------------AAATTTTGACTCA---- -----------------GTTAAGAGCCAGCCGCTG----------------CTCAGCTTA TT-------------AAACAAACAGCCGT------------------------------- ----------------------------CCTATGCTGCCGAAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ACCCTAATCCAGTGG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------CCCAGCC--TGTCAGGGTGGAAA---------------------- -------------------------------------------------------TCTTT CAA------------------------------GCCTTGTTTGCAAACAGGCCT------ ------------GGCCTGTGTTGTTACGTGCCCAA---------------------GTGG TCACCTCTCCCAGCCTCAGAACT-----AAGGCCGTCAGCCTT---------------GT CCAACTTTAG--ATCCCA------------------------------------------ --------------------------------------AATAGCTGAATAGCCCAGCAAG GGAATACATCTTCTGCCCAGTCTGACCAGAGGCAATTGCAGA------------------ ------ATCCAGTCAGCAACTTTGCC---------------------------------- ------------------------------------------------------------ ----------TAATAGAAGACCCCAGC----------------------------CAGCG ATCTCG------------------------------------CTGGACCTCAGAGCACAG CCAGCTGTC--------------------------------CCATGAGACA--------- ------------CCGGATCAAAG---------------GTAGCAGCCCAGCCCAAACTAA AGAAA-------------TGACA---------ACAA------------------------ --------------------------------------------TGTCTACATGTCTGGG G---TTATTACCAGCTAGCCCACCC----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AGAATCACAGGCAA------------------------------GAC T-----------AAATAGTG---------------------------------------- ------------------------------------------------------------ --------------------------------------AAGATCTATCCCCAC------- ------------------------------------------------------------ -----------AAAAGAAC----------------------------------------- ------------------------------------------------------------ ---ACTAGGA-AGGCTAGA----------------------------------------- ---AGAGGGAGCCTGTTTCTT--------------------------------------- ---------------------------------AAAGTTCAAAG---------------- ------ATACCAGTATGAGACATAATAACAAA-------GAAGTAAAGAAGAATAAGACA ATCCTGACAAAGT-----TAC------------AAGAATGCAATAAAGTT---------- CCAA---TAATCGACCTCA-------AA--------GGAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GGAAGATTTATG AATT------CACTGAAA------AAGAA------------TTCTAAAA---AATTCT-T TTAATGA---AGTTCAGTGAACT----ACAAGAAAATA---------------------- --------CAGATAAGAAATTAAATGAAATTTGGAAAACAAATCATTGACAAAAT----- ----------------------------------------T------------------- -------AAAAATTTAATAAAAAAA---AAAAAAACAAA--------------------- ----------------------AAAAG-------------AAGA------AATAAGAAAG --------------------------------------ATAGAGAATAGAATAACAATGA CTAAACTAAAAAAATAAATTAAAAAGTAAAGCTTAACAGCGAGCTAAA------------ ------------------------TTGT-AGATA---TAAAA---------AATAA---- -AATAACTGAA----ATGAAAAATTCAATAG-------AAAG------------------ --------------------------------------------GTTTAACAGCAGAAT- -----TGATC--AAGC------------------AGAAG---------AAAA-GAT-CAG TGAACTT----------------------------------------------------- ------------------------------------------------------------ ----AAAAAAAGGAAATTTAAAA-T--TATCAAA------TTAG---------AAGA--- ------------------AAAAAAAAAAAAA---AAA---ATAAAAAAAAA--------- AAA-AAACAGCCTAAGG--AAATTATGGG-ACACCATC-----------AAACG--GACT AATCTATGCA-TAATTGG--AGTTCTAAAAG-----------------AAAAAGAGAAAA AAAAAGGAACAG---------AAAGTATATTTAA--A--------GAAATAATGAC-T-G AAAACTTCCCAAATCT--------------------GGGGAAAGATATAA--ACATTCAG ATAC-----AGGAAGCTCAAAAGAT---TTCAAATAAAAT--------TAA--------- -----TCCAAAAA-----AG---ACTCAAA----------------------------GA CATATCATAATCAAATT-------TCAAAAAA---------TCAAAGAAA---------- ------------AAA--AAAAAATTT---------------------------------- --------TGAAAACAGCAAAAGA---AAAAAAAC--------------ACATCAC---A TAC----------AAGG--------------GAACCCCAAT--AAATTTGT-C--AGCAG AAT--------TTTTAGAAAAAAAATCT---AAGG--CCAGAGGGAAGATG--------- ----GAAGTAATATA-T-------AAAAAAATT-AAT-GAAAAAAAAA------------ -AAT-TT--CCA---CACAAAA--------TTTTGT----------ATACA--------- --GACAAAATATGC-----TTTA-CAAAAGA-------AGG-AGAAATAAAAAATTTTTC AAACCAAAAAAAGGTTAAGGGA-TTTTATAACAACCAACC---CTGCTTAA--AAGAAAT GCT--------------AAAAAG----------------------AGTTC---------- ------------------------------------------------------------ --------------------------------------TTTATAGGGATAATTTAAACAG AAACAACCAAACTTAAGCTGAAACAAAAGGCTGCTAATTAATAACATAAAAAAAAATAAA AATCTAAAATTCACAAT------------------------------------------- -----------TAAAT-----------AAGTAATACATAGTCATATTCAGAATACTCTAA TACTGTAATGGTGGTGTGTAAAGCAATTTTATCC---CTAGTATGAGGGTT--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AAAAGACAAAACTATTAAAAA CAACT------------------------------------------------------- -----------------------------------ATAGCTACAATAAATTGTTATGAAA TAAAAAAATATAAATTATGAAAATAGTGACATCAAAATCATAAAAGGTGGAGGGGGGGGA AAAAAGAGTGAAGGT--------------------------------------------- ------------------------------------------------------------ ----TTTGTATGTAATCAAAGTTAAGTTGTTATCAGCTTAAA------------------ ----------------------------------ATAG-------------CCTGTTTTA AGTATAAGATGTTTTATGTAAGCCTCATGGTAACCACAAAGCAAAAACCTATAGTAG--- ------------ATACACAAAAAATAAAAAGAAAG-----------GAATCAAAGCATAC CACTAC------AGAAAACCATC----------------------AAAC-----CACAAA ----GG------AAGACAGCAAG--AAAGGA-------AGAAAGA-------AACAAAAG ATCTACAAAACAACCAGAAAACAATTAAC---------------------------A--- ------------------------------------------------------------ ----------------------------------AAACCTATCAATAA------------ -------------TTAC-CTTGAATG-TAAATGGATT--AAATTC---TCCAATAAAAAG ACATAGAA--TGACTGAA-TGGAT---------TATAAAAAAAAAAAACCAAACTA---- ---TAG-CTTGTTTAAAAGAA-ACTCACTT-TACTT--TTAAAGACACACATAGACTGAA AG--TGAAGGGA--TGGAAAA-AAATATTTCATGCAAATAG------AAACC-------- -------------AAAAA-AGAGCAG--GGGTAGCTATACTTATATC-AGACAAAATAGA CTTTAAG-TC----------AAAAACTGTAAAAAGAGAC-AAAG-AAGGTCATTATAT-- ----AATGATAAA---AGGGTCAATTCATC--AAGAGG--------AT-ATAACAATTGT AA-----------------ATATATATGCACCCAACATTGGAGCACCTAA--ATATATAA AGCAAATATTAAAAGATCTGAAGGGAGAGATAGACTGCAATAC---------AATAATAG TAGGGGACTTCAATACCCCAC-----TTTCAACAATGGACAGA----------------- ----TCATCCAGAC------AGAA-----AATTAATAAGGAAACATTGGACTTG------ --AACTACACTTTAGACCAAATGGAC-CTAACAG--ATATATACAGAA--CATTCCATCC AACAGCAA---CAGAATACACATTCTTCTCA-------AGTACACAT---GGAACATTCT C------CAGGATAGATCATATGTTAGGCCACAAAACAAG-------------------- -TCTTAACAAATTTAAGAAGA--TTGAAAT----------------CATATCAA------ -GTATCTTTTCT---AACCACAATGGTA-TAAAACTAGAAATCAATAACA--------GG A-------------GA-AATTTTG---GAAAATTCACAA----ATATATGGAAATTAAAC AACATG-CTCCTGAA---CA-ACCAATG--GGTCA---AAGAAGAAAT--AAA-AAGGAA AATTAAAAAATATCTT---GAGAC------------------------AAATAAAAATGA -AAACAAAAA--ATACCAAAAATTAATGG-AATGCAGCAAAAGCAGTTCTAAAAGGAAAA --TTTAAAGCAATAAATATCAA----AAAAAAG---AAGA--AAGATCT---CAAATAAA ------CAACCTAATATTACACCTCAA---GGAACTAGAAAA---AA---AAGAACAAAC TAAGCCCA-AAGTTAGCA------------GAAGGAAGGAAATAAT-AAAGATCAGAGCA GAAATA---AATGAAATAGAGACTAGAAAAA-CAA---TAAAAAAAATC-AATAAAACTA -AGAGT-------TGGTTTTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGACAAACCT---TTAGCTA------GACT-------------- ----AAGAAAAAA-----A---GAAA-AAAAACAAATAAA-------------------- -----TAAAA---T---------CAGAAATGAAAGA------GGAGA---CATTACAACT G--------ATAC-CACAGAAATA-CAAAGGATC--ATAAG---------AGACT----- -------------------ACTATGAACAA-TTATATGCCAACAA--AT---TGGATAAC CTAG---AAGAAAT--GGATAAATTCCT--A---GACACA---------TAC-----AAC CTACCA------AGACTGAATCATGAAGAAATAGAAAATCTGAAC--------------- --------AGACCA------A------TAATGAGTAAGGAGAT----TGAAT--CAGTAA -TAAAAAGTCTCCCATCAAAGAAAAG--CC-CAGGACC--TGATGGCTTCACTGCTGAA- TTCTA------------CCAAACATTT----AAAGAAGAACTAATA-CCAATC-----C- ----TTCTCAAACTCTTCCAA-------AAAATTG-AAAAGGAGGG-----------AAT ACTTCCAAACTCATTTTATAAG---------GCCAGCAT---TACCCTGATACC--AAAG C-----------------------CAGAC--AAGGACA-CTAC----AA---------GA AAAGAAAATT---------------------ACA------GGCCAATAT--CCC----TG ATGAACATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACCA------------------AA--T------------ ---T-CA--ACA-------------ACACATT---------AAAAGAATCATTCA--CCA ----TGAT------------CAAGTGGGA-TTTATCCCTGGGA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATGC----AAATCAATAAATGTG--ATA CACCAC---------A------TTAACAG----AATGAAGGACAAAAAC---CATATGA- ----TCATCTC---AATA----------GATGCAGA-AAAAG---CATTTGACAA---AA TTCAACATCCTTT-------------------CATGA---------T-AAAAAC-TCTCA --ACAAATTAGGTATAGAAGGAATGT-----ACCTCAACACAAT---------------- -----------AAAGGCCAT-ATAT-GACAAGCCCACAGC-----------TAACAT--C ATACTCAATGGTGAAAA-G-----TTGAAAGC-TTTT---CCTCTAAGAT----CAGGAA CAAGACAAGGATGC-------CCACTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTTCTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATTAG------GCAAGAG---AAAGA--AATAAAAGGC ATCCAAATAGGAAA-------GGAAGAAGTGAAA--TTGTCTCTG-----TTTGCTGATG AC--ATGATCTTA-------TATATAGAAAACCCT---------------AAAGA---CT CCACCA---------AAA--AACTGTTAGAACT---------AATAAA--CAAATTCAGT AAAG--TT-------------------------GCAGGATACAA--------------AA TCAACAT------------ACAAAAAT----CAGTAGCATTTC--TA-TACACTAA--CA ACAAACTATCTGA------------------AAAAGAAA-TTAAG----AAAACAATCCC ATTTACAATAGC-TACAAA---AAAAATAAAATACTTAGGAATAAATTT--------AAC -CAAGGAGGTGAAAGATCTGT---ATACTGAA--AACTATAAAACATTGATG-AAAGAAA TTGAAGA-----------AG------------------ACAC--AAAT--AAATGGAAAG ATAT------C---CTATGTTCATG------GATTGGAAGAATT-----AATA-TTGTT- ------------------------AAAATGTCCA-TA-CTACCC-AA------------- ----AGTAATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------TCCAATG- TC------------ATTTTT---------------------------------------- --CACAGAAATAG---AAA------AAAAAATCCTAAAA-TTTATATGGAA-------CC ACAAAAAACCCA---AA--ATAGCCAAAGCAATCATGAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACA---CTACCTGATTTCAAAAT-----ATATTACAA---AGCT ATAGT-AATCAAAAC-AG------CATGGTACTGG--CA-----------------TAAA AATAGACA------CATTAAC--CAATGGAACAGAATAGAAAGCCC------AG--AAAT AAA---CCCACACATTTATA----GTCAAT--TGATTTTT---GACAAA--GGTGC--CA AAAAAAAAC--AATGG-----GAAAAAG----ACAGT--------CTCTT--CAATAAAT GGTGTTG----------G-GAAAAC--TGG-A-TATCCA---------------CATGC- AGA---------AGA--ATGAAATTGGACCCTT----ATCT---------------CACA CC--ATATACAAAAA-TCAATT-CAAAATGGATTAAAGACTTAAATGTA--AGACCTGAA ACT-GT------------------------AAAACTACTAGAA----------------- ------GAAA--ACATA------G---------GGG---------AAAAACTCCATGAC- --ATT-----GG-TCTGGGCAATGATTTTTTGGATAT-GACCCCA-AAA----GCACAGG CAACAAAAGCAAA----A------AT---AGAC--AAA-TGGGATTGC--AT-------- -------------------------------------------------------T-AAA ATAAAAAGCTT-CTTCA---AAAC-AAAAGAAA---TCAAC-AGAG-TGAAGAG-ACAAC CTAT--AGAT--T-GGGAG--AAAATATTT---GCAAACCATACAT--------CTGATA AGGGGTTAA-------TATCCAAAATATATA--AGGAA--CTCAA-----ACAAC----- ----------------------TCAATAGAAA------GAAAAC------------A--- AATAACCTAA-TTAAAA----------AATGGGCAAA-----------AGA--CCTGAAT ---AGACATTTCTCAAAAGAAGACATACAAA--------------TGGCCAAC-AGATAT ATGAAAAAATG----CTCAACATCACTAA-TCATTAGGGA-AAT--GCAAATT-AAAACC ACAATGAGA---------------------TATCACCTCACACCTGTTAGAATGGCTA-- ----TTATCAAAA---AGATAAAAG-----------ATAACTG-------TTGGC-A--- ---------------AGGATGTGGAGAA-------------------------------- -----AAGGGAACCCTTGT-ACACTGTTGG--TGGAAA---------------------- -------------TGTA-------------AATTA-GTAAAACC--------ATTTTTG- -------AAAACT-GTATAGAG--GTTC-CTCAAAAAACTAAAA--ATAGAATTACCA-- -TATGA--TCCAGCAATCCCACTTCTGGG-TATATA-TCCAAAAG-AAA--AAAA----- -------------------ATCAGTTT-TTCAA--AGAGATATCTG----------C--- ---------ACCCC--CATGTTCATTGCAGCATTATT---CACAATA-GCCAAGATAT-G GA--ATCA--ACCTAAG-TGTCCATCA---ATAGATG-----AATGGATAAA--AAAAA- TG---------------------------------------------------------- --------------------TGGTATATAT----ACACAATGAAATAC--TATTCA-ACC TTTAAA----------------------AAGAAAGAAATTCTGTCATTT----------- ------------------------------------------------------------ -GTAACAACATGGATGAAC-C---T----------------GGAGAACATTATGCTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GGCAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAT---- -----------------------------------AC-TGCATG--------TTC----- ------TCACT---TAT------------------------AAAT---------CTAAAA A-------A--------------GTTGAA---------------C--------------- ------------------------------------TCATA-------------GAAG-- -------TA------------------------------------------GAGAGT--- -AGAATGGTGGT---TACCA-----GAGGCTGGG---------GGGGGG----------- -GGGGGGGAGGG------------------------------------------------ --GGA------TGGGGAA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TGG--------------GGAGATGTTG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GTCAAAG---------------------------------------------- --------GGTA----CAAAGTTT------------------------CAGTTAGACAGG AGGAAT--------------------------AAGTTTTAGTGATCTATTGC-------A CAG-----------------------------------------------------CATG GTGACTATAGTT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AATAATAATG-- ----------------------TATTGTATA--------TTTCAAAATTG---CTAAA-- -------------AGAGTAGATTTCAAATGTTCTCACCACAAAAAATGTTAAG------- ---------------------------------------TATTTGAGGTGATGGATATGT TAATT-----AGCTTGATT------------------------------TAATCATTCCA C-----AATG-TATACA-------------------------------TATATC------ ------------------------------------------------------------ ----------------------------------------AAAACATCACAT--TGTACC CCATAAATATATACAATTA------------TTATTTG----TCAATTAAA------AA- -------TAA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MA9 ---------------------------AATGTTAGCAAGTTG--GCAAAAT-AAAAGTCC CCTGCCCTTTT---TCCCCCCA--------AAGAAACACACA------------------ -----------------------------------------------TC--------TAC AT--TTTGTCCC--A-----AATACCTAAAGAAGATTACGAGAA-----------CT--- -----------------GCAGAATACACTCGAAAA--------------ATCACAGAAAT C-------------CAAGATGGTAAAAAAGACAAAAAAAGACAAAGCCTAAACTCTGCCA CCCCAAGTCCCACTTTACCCACAGCTCCCCACCGCCGCAGACACCTTGGCTTAGTACCG- -------------GGAGGGACCCGCTCACT----CCCAGCTCCCCCC-----AGCGGATA GAACAGTTTGCGTATC------GCATCAACCCTTACCACCACCA-TGAGGAATGCTGGCT T-------------------------TCACGCCTGACCCCTACAGTCATCACAGATAACA TGAGAACAGTAGGTGTAAGTATCCTGCAGATATTTAAGAGTAGAAAAAAGAAAGATAGGC TCACAGACACCAGAGAACAGAACTTAAAATAATATGTTAAAATATTAACATAAAATAATA ATAATAATAATAAAAGAACCAAAATAATATATCAAAAGAACTTTAAAAAAGAGCCAAGAA CTCCACCAAAAGATTCACTTATAAAGCTTGTCTTCTGAATCCCTCGCAGATTTTATCCAC TTCCCCACGTACTCACAGACCATTTAGGGTTTTATTTCTTGAGAAGATTTTATTAGGGGA TCGAAAGCCCAGA------------GTTTGCGAGAGTTCTATTTGTGCCCGCTGA----G CTATTACATCAGAC-CCAGCGAGGGCTCCGCCGTCCCTTAGTCGGA-------------- ---CAGGTGGCCGGAGCTTCTCCACCGACCGCTTGG------------------------ ------------------------------------CAGGCCGAATGCACACCTGCTAAC GACTCCACCCTTTCTAAGTCACCCTAAGAGGCCAGCTTGGAAACTCT------------- -GCCCGGACCTCGCAGCGGCC-------------------AACAATCGTTGCCCTAG--- --------------------------------------------AGGTGTGAGAGACGGA GCACTGTTGTGGCAGACGTGCCATCCTAGCCTCTGCCCTCTGCAATCCGAAACCTGCCCC CCCCCTTTCCCTGCTCCACGCAGTACATCTTGGAT----------------CACCCGCAT CT-------------GACCTTCCCTGGTGCTTCGGTTCCCCACAGTTGGGCGTTAAGTGA ACCGGATTTCGCATTGGGGATGCAGGCGCAGCTACAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TTCTCTCGGGACCCCAGCAGAGTGGTACTGGCTTCA TGGACATCCCC------------------------------------------------- ------TACCCCTCGGGAATCATTGCCCCTGCAACCGTTTGGCGGCAAGGGTCCTGGGGC CGAGACGAGCTGGTACCGGGCACGCCGGGGGTCTGC---AGTGATTGGCGAGCTGGACCC TTCAGTCCTACTGTCTGAGCAGCATCGTCGCACAATCCTCTGAGTGCGCTCGCTCCTGGG GGCCAGGGGCCCGAGAGTGCTTCCAGCCCTTGGCGTCTTAGGGTGAGGCTGTTTTGCCCC CTCCTCCCTGCAGGAAACTAAGCTTCGACTGCTTGCCGTTCCAGCGT------------T GCTGCTTCCTAGGCACCGTGCC--TCCCACCTCCTGGGATACACCTCTGACCGCGCAGTC AGGGGTCTAGCC----------G--------------GTTATCTGTCTGCCTCCTCCCCC CCGGGGGCAGAGCGGGGGGTCAGGACAGGCGCCCCCAGCCTTGGGGTTGGAGACTTCAGT GGCCCCCTGGCTTCCCAGCGGTGCCCGCAGCCGTC---------------------GCTG CCCCGGCGCCC---CTCAGTCCCTGCCCGGGCCTTGCTGCCCC---------------GG GTGGAGGGAC--CGCCCACTAGCGT--------------------CCCGGCGCCAGACCC CGCCCCGCATCCCCCAGGCCCACAGCGCATCCACCCCCCGGCACCCCTCCCC-------- -----ACATCCCTGCTGGCGGCTCCCGCAGGTTCTGGCCCCG------------------ ------CCCCCCCCTGTCACCCAG------------------------------------ ----------------------------------------------GCCCGCTCCTCGTG AGTGCCCATACAGGGGGGGACTGCAAGCACCCCGCACCGGCACCCTGCCTATGGATGCTA GACTAAAAG---------------------------------CCACCACTCCTGGACCCC CCAGGCCGC----------GCCCCCAAGGCTATCACGGTCGTTACTGATCC--------- -----------------------------------------------TGCCCTGACGTGA GAAGG-------------CGGCA--------CACAG------------------------ ----------------------------------------------TCTGCTGCTCTGCC C---CCCCAGCGGCAATGAGAC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CAGTGAACCCCGCC-----------------------AGC C-----------AGCACACAAAGTCTGAGAGCTCCT------------------------ ------------------------------------------------------------ ----------AAGATCCTCTCGGG-----ATGCCGGGAGGGGGGTTTCCCTCC------- ------------------------------------------------------------ -----------TGAAGCCA----------------------------------------- ------------------------------------------------------------ --GTCTGTAA-AGACTGGA----------------------------------------- ---AGAGGTGACTGCTTCTTC--------------------------------------- ----------------------------------AAATGCGCAG---------------- ------ACATCAAT-------GCAAGGACACA-------AGAAACATGAAAAA-CAAGGA AACATGACACCAC-----CAA------------AGGAACAAAATAATTT----------- CCAG---TTACCAACCCCC-------AAG-------AAAT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GGA-GATCTATG AATT------GCCTGACA------AAGAA------------TTCAAAAT---AATTAT-- TTAAGGA---AGCTCAGTGAGCT----ACAAGAGAACA---------------------- ------------------------------CAGATAGACAACTC---AATAAAAT----- ----------------------------------------C------------------- ----AGGAAAACAATACATGAACAA---AATGAGAAGTT--------------------- ----------------------CAACA-------------AAGA------GATAGAAAAT ------------------------------------ATTAAAAAAAAAAC---------- -----CAAACAGAAATTCTGGAGCTGAAGAATACAATGACTGAACTAAAATATTCAATAG AGCCGCA-----------------TTCT-GGAGC---TGAAA---------AATAC---- -AATGAGTGAA----ATGAAAAGAGCAATAG-------AGAG------------------ --------------------------------------------CTTCAACAGCAGACT- -----TGATC--AAAC------------------AGAAG---------AAAG-AAT-GTC TGAAATGGAAATTTATAAATTGCGTAAAAAGTCATTTAAAATAATGATAATAATGGAACT GAATAAGACAATAAAAGAAATAAAAAATTCATTCGATAAAATCAACAACACAATTGATCA AGTAGAAGAAAGAATTTATGAAC-TAGAAGATAG------GTCATTTAAAATGACTA--- ------------------AGTTAAAGGAAAAACAAAA---AAAAAAAAAAATAAAAAAAA TTA-AAAAAACCTACAG--GACTTATGGG-ACACCATT-----------AAGTG--AACA AAAATTCACATTTATAGG--AATTCAAGAAA------------------------GAA-- AAAAGGGGATAG---------AAAGCTTATTTAA--A--------GAAATAATGGC-T-G AAAACTTCCCAAGTCT--------------------GGGAAGAGAAATGG--ACATCCAG ATCC-----ATGAAGCTCAAAGATC---CCCAAA-TAGAT--------TCA--------- ---A-CCCAAAGA-----GGTCTTCTCTGA----------------------------GA CACATTATAATCAAATT------GTC-AAAAG---------TCAAAGACA---------- ------------AAG--AGAAAATTT---------------------------------- --------TAAAAGCAGCAAGAGA---AAAGCATC--------------TAATCAC---A TAT----------AAGG--------------AAATCTCCAT--TAGACTAT-C--AGTGG ATT--------TCTCAGCAGAA--ACCTTG-CAGG--CCAG-GAGAGAATG--------- ----GGA-TAATATA-T-------TCAAAG--T-GCT-GAAAGAAAAA------------ -AAC-TG--CCA--ACCAAGAA--------TACTAT----------ACCCA--------- --GCAAAGCTGTCC-----TTCA-GAAATGA-------AGG-AGAAATAAAGTCTTTCCC AGACAAGC-AAAAGCTGAGGGA-ATTCATTACCACTAGAC---CTGCCTTAC-AAGAAAT GCT--------------TAAGGA----------------------AGTTC---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------TTCAAGTAGAAAACAAAAGGATGCTAATTAGCAACATGAAAACATATGAA AGTA-------------------------------------------------------- -----------TAAAACTCATGGTAAAGGTAAGTATATAGTCAAATTCAGAATACTCTAA TACTGTAATGGTGGTGTGTAAATCACTTTTAACT---CTAGTATAAAGGTT--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AAAAGACAAAAGTATTAAAAA TAACT------------------------------------------------------- -----------------------------------ATAGCTACAATAATTTGTTAATGGA TACACAATATAAAAAGATGTAAATTGTGACATCAATAACATAAAATGTGGTGGGGGGGGG GGAAGTAAAAGTGTA--------------------------------------------- -----------------------------------------------------------G AGTTTTTGTATGTGATTGAAGTTAAGTTGTTATCAGCTTA-------------------- --AAATAGACTGTTATAACTTAAGATGTTTT---ATGT---------------------- -------------------AAGCCTCATGGTAACCACAAGG-------------AAAAAA CCTGTAGTAGATACACAAAAGATAA---AGAGAAG-----------GAATCAAAGCATAC CACTAC------AGAAAAATCAT------C---------------AAAT-----CACAAA ----GG------AAGACAGCAAG--AGAGGA-------AGAAAGG-------AACAAAGG AACTACAAAACAGTCAGAAAACAATTAACAAAATGGCAATAGT-------------AAGT CCTTACCTATCAATAATTACTTTAAATGTAAATGGATTAAATTCTCCAACTGGCA----- --------------------GTAGTAA--GTTC-TTACCTATCAATAA------------ -------------TTAC-TTTAAATG-TAAATGGATT--AAATTC---TCCAATCAAAAG ACATAGAG--TGGCTGAA-TGGAT------------TAAAAAAAAAAACCCAACTA---- ---TAT-GCTGCCTACAAGAG-ACTCACTT-TAGCT--TTAAGGACACACATAGGCTGAA AG--TGAAGGGA--TGGAAAA-AAATATTTCATGCAAATGG------AAACC-------- -------------AAAAG-AGAGCAG--GGGTGGCTATACTTATATC-AGACAAAATAGA CTTTAAG-TC----------AAAAACTGTAAAAAGAGAC-AAAG-AAGGTCATTATAT-- ----AATGATAAA---GGGGTCAATTCATC--AAGAGG--------AT-ATAACAATTGT AA-----------------ATATATATGCACCCAACATTGGAGCACCTAA--ATATATAA AGCAAATATTAACAGAACTGAAGGGAGAAATAGACAGCAATAC---------AATAATAG TAGGGGACTTCAATACCCCAC-----TTTCAACAATGGATAGA----------------- ----TCATCCAGAC------AGAA-----AATCAATAAGGAAACAGTGGACTTG------ --AACAACACTATAGACCAAATGGAC-CTAACAG--ACATATACAGAA--CATTCCATCC AACAGCAG---CAGAATACACATTCTTCTCA-------AGTACACAT---AGAACATTCT C------CAGGATAGATCATATGTTAGGCCACAAAACAAG-------------------- -TCTTAACAAATTTAAGAAGA--TTGAAAT----------------CATATCAA------ -GTATCTTTTCT---GACCACAATGGTA-TGAAACTAGAAATCAATAACA--------GG A-------------GG-AAAATTG---GAAAATTCACAA----ATATGTGGAAATTAAAC AACACA-CTCCTGAA---CA-ACCAATG--GGTCA---AAAAAAAAATAAAAA-AAAGAA AATTAAAAAATATTTT---GAGAC------------------------AAATAAAAATGA -AAACAAAAC--ATACAAAAAC----TAGGGATGCAGCAAAAGCAGTTCTAAGAGGGAAG --TTTATAGCAATAAATGCCTACATTAAGAAAA---AAGA--AAGATCT---CAAATAAA ------CAACCTAACTTTACACCTCAA---GGAACTAGAAAA---AG---AAGAACAAAC TAAGCCCA-AAGTTAGCA------------GAAGGAAGGAAATAAT-AAAGATCAGAGCA GAAATA---AATGAAATAGAGACTAGAAAAA-CAA---TAGAAAAGATC-AATAAAACTA -AGAGT-------TTGTTTTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGACAAACCT---TTAGCTA------GACT-------------- AAGAAAAAAAAAA---------GAGA-AAACACAAATAAA-------------------- -----TAAAA---T---------TATAAATGAAAGA------GGAGA---CATTACAACT G--------ATAC-CACAGAAATA-CAAAGGATC--ATAAG---------AGACT----- -------------------ACTATGAACAA-TTATATGCCAAAAA--AT---TGGATAAC CTAG---AAAAAAT--GGATAAATTCCT--A---GAAACA---------TAC-----AAC CTACCA------AGACTGAATCATGAAGAAATAGAAAATCTGAAC--------------- --------AGACCA------A------TAATAAGTAAGGAGAT----TGAAT--CAGTAA -TCAAAAACCTCCCAACAAAGAAAAG--CC-CAGGACC--TGATGGCTTCACTGGTGAA- TTCTA------------CCAAACATTT----AAAGAAGAATTAATA-CCAATC-----C- ----TTCTCAAACTCTTCCAA-------AAAATTG-AAGAGGAGGA-----------AAC ACTTCCAAACTCATTTTATAAG---------GCCAGCAT---TACCCTGATACC--AAAG C-----------------------CAGAC--AAGGACA-CTAC----AA---------GA AAAGAAAATT---------------------ACA------GGCCAATAT--CCC----TG ATGAACATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACCA------------------AA--T------------ ---T-CA--ACA-------------GCACATT---------AAAAGGATCATACA--CCA ----TGAT------------CAAGTGGGA-TTTATCCCTGGGA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATAC----AAATCAATAAATGTG--ATA CACCAC---------A------TTAACAG----AATGAAGGATAAAAAT---CATATGA- ----TCATCTC---AATA----------GATGCAGA-AAAAG---CATTTGACAA---AA TTCAACATCCTTT-------------------CATGA---------T-AAAAAC-TCTCA --ACAAATTAGGTATAGAAGGAATGT-----ACCTCAACATAAT---------------- -----------AAAGGCCAT-ATAT-GACAAGCCCACAGC-----------TAACAT--C ATACTCAATGGTGAAAA-G-----CTGAAAGC-TTTT---CCTCTAAGAT----CAGGAA CAAGACAAGGATGC-------CCACTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTTCTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATTAG------GCAAGAA---AAAGA--AATAAAAGAC ATCCAAATTAGAAA-------GGAAGAAGTAAAA--TTGTCTCTG-----TTTGCAGATG AC--ATGATCTTA-------TATATAGAAAACCCT---------------AAAGA---CT CCACCA---------AAA--AACTTTTAGA------------AATAAA--TAAATTCAGT AAAG--TT-------------------------GCAGGATACAA--------------AA TCAACAT------------ACAAAAAT----CAGTTGTATTTC--TA-TACACTAA--CA ATGAACTATCCAA------------------AAAAGAAA-TTAAG----AAAACAATTCC ATTTAAAATAGC-AACAAA---AAAAATAAAATACTTAGGAATAAATTT--------AAC -CAAGGAGGTAAAAGATCTGT---ACACTGAA--AACTATAAAACATTGATG-AAAGAAA TTGAAGA-----------AG------------------ACAC--AAATAAAAATAAAAAG ATAT------C---CTATGTTCATG------GATTGGAAGAATT-----AATA-TTGTT- ------------------------AAAATGTCCA-TA-CTACCCAAA------------- ----AGTAATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------TCCAATG- GC------------ATTTTT---------------------------------------- --CACAGAAATAG---AAA------AAAAAATTCTAAAA-TTTATATGGAA-------CC ACAAAAGACCCC---AA--ATAGCCAAAGCAATCTTGAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACA---CTTCCTGATTTCAAAAT-----ATATTACAA---AGCT ATAGT-AATCAAAAC-AG------TATGGTACTGG--CA-----------------TAAA AACAGACA------TATAGAT--CAATGGAACAAAATAGAGAGCCC------AG--AAAT AAA---CCCACACATATATG----GTCAAC--TAATCTTT---GACAAA--GGTGC--CA AGAAAACACAAAATGG-----GGAAAGG----ATAGT--------CTCTT--CAATAAAT GGTGTTG----------G-GAAAAA--TGG-A-TATTCA---------------CATGCA AAA---------AAA--AAAAAATTGGACCCTT----TTCT---------------TACA CC--ATACACAAAAA-TCAACT-CAAAATGGATTAAAGACTTAAATATA--AGACCTGAA ACT-AT------------------------AAAACTCCTAGAA----------------- ------GAAA--ACATA------G---------GGG---------AAAAGCTCCTTGAC- --ATT-----GG-TCTTGGCAATGATTTTTTGGATAT-GACACCA-AAA----GCACAGG CAAAAAAAGCAAA----A------AT---AAAA--AAA-TTGGATTAC--AT-------- -------------------------------------------------------C-AAA CTAAAAAGCTT-CTGCA---CAGC-AAAGGAAACAATCAAC-AAAA-TGAAAAG-GCAAC CTAT--AGAA--T-GGGAG--AAAATATTT---GCAAACCATATAT--------CTGATA AGGGGTTAA-------TATCCAAAATATATA--AGGAA--CTCAT-----ACAAC----- ----------------------TCAATAGCAA------AAAAAA------------A--- AATAACCTGA-TTAAAA----------AATGGGCAAA-----------GGA--CCTGAAT ---AGACATTTTTCAAAAGAAGACATACAAA--------------TGGCCAAC-AGGTAT ATGAAAAAGTG----CTCAACATCACTAA-TCATCAGGGA-AAT--GCAAATC-AAAACC ACAATAAGA---------------------TATCACCTCACACCTGTTAGAATGGCTA-- ----TTATCAAAA---AGACAAAAG-----------ATAACAA--GTG--TTGG--G--- ---------------AAGAGGTGTGGAA-------------------------------- -----AAGGGAACCCTTTTCACCTTTTTGG--TGGAAA---------------------- -------------TGTA-------------AATTG-GTACAGCC--------ATTATGA- -------AAAACA-GTATGGAG--GTTC-CTCAAAAAATTAAAA--ATAGAACTACCA-- -TATGA--TCCAGCAATCCCACTTCTGGG-TATATA-TCCAAAGG-AAA--TGAAATT-- -------------------ATCAATAT-CTAAA--AGAGATATCTA----------C--- ---------ACCCC--CATGTTCATTGCAGCATTATT---CACAATA-GACAAGATAT-G GA--AACA--ACCTAAA-TGTCCATCG---ATAGATG-----AATGGATAAA--GAAAA- TGTTATATTTATATATAGGGATACTATTGAGCCTTAAAAAAGAGGGAAATCCTGTCATTT GTGAAAACACATACAATGTGTTATATATAT----ATACAATGGAATAT--TATTTA-ACT TTAAAAAAGAAA----------------AAAAAGGAAATCCTGCCATTT----------- ------------------------------------------------------------ -GCAACAACATGGATGAAC-C---T----------------GGAGGACATTATGCTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GACAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAG---- -----------------------------ACAAATAC-TGCATG--------ATC----- ------TCACT---TAT------------------------AAAT---------CTAAAA A-------A--------------GTTGAA---------------C--------------- ------------------------------------TCATA-------------GAAG-- -------CA------------------------------------------GAGAGT--- -AGAATGGTGGT---TGCCA-----GGGGCTGGG---------GGGGGG----------- ----------GG------------------------------------------------ --GAA-----ATGGGGAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------ATG---------------------TTG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GTCAAAG---------------------------------------------- --------GGTA----CAAAGTTT------------------------CAGTTATAA--G ATGAAT--------------AAGTTCTGGAGA------------TCTAATGT-------A CAG-----------------------------------------------------CATG GTGACTATA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GTTAATAATA-- -------------------CTGTATTGTATA--------CTTGAAATTTG---CTAAG-- -------------AGAGTAGATCTTAAGTGTTCTCACCACACACACACACAAAAACAAAT AAAAAGACAAAAAAATGGTAACTATGT-----------------GAGGTGATGGATATGT TAATT-----AGCTTGATT------------------------------GTGGTAATCAT TTC---ACAA-TGTATA-------------------------------TGTATA------ ------------------------------------------------------------ ----------------------------------------TCAAAACATCATGTTGTACA CCTTAAATATATACAATTT-TTATTTGTCAATTATACC----TCAATAAAG------CT- -------GGAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MA6 ---------------------GATAAGCATGTCATCTAGAGGGTTGTGTCC-AGCATTCA CCCCGCCTTTC---TCCCCCAA--------GAAAAAGAGACC------------------ ---------------------AAAG---------CAACAAATAAACAAC--------TAT AT--TTCAACTGA-------AGTGACTGAGGAAGAGTGCTGGGC-----------AGCAC CAGG---GGAGTGGCAAAATCTGTGTGGCATAGAA---------------GCACCGG--- ----------------------AGATCGCAATAGAAAGGGGAGAGAGACACCCTGCCTCT GCGCCACTGTCTCCCCTCCCA---------------------GGATTAGCTCCGAGTCG- -------------AGGAG--GGCTTCTTCT----TACAG----------------GAGAA AGGTAAGGTGG--------------------------AAGCCCC-TAGTTGTCCCCCATT C-------------------------CTGCCACAAATACCAGCAGTT-------TCTGCT AGAGGGTCCCATCCGTCCCTCCCC------------------------------------ --------------GACCTCAATCGCACTGGG------------------GCCATTGCTT GAGGTATCTGCA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CTGTCTTGCTCTACGGGTAGG GGCCCATCTTTAGT-CCCC----------------------------------------- -------------------CCCACTCCTGTGACCTAAGCTGCTATGGCACAGCAC----- ------------------------------------CATCTTGAACCCAGA--------- -------------------CCCACTGCTAGA----------------------------- -GCATGGTAGACGCTAAGGGCGCGTCTCCAATGATTCTCTCCTTGCCACAGCCCCTA--- -------------------------------GCCCAACTGTCCCTGGATGACATTACCTT CACA-------AGAGCTACGGATCCCTGA--------------ACACATAAGCGAG---- ----------------GCCCTGAAGCCCCCTTGGAATACAAAGATGAGCAAATCCG---- ------------------------------------------------------------ -------TGCCTG-------------GACCCTAGTGGGACTGGT---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------TCCCTATCTCTATGA-------------------TACTGCT GCCCCCGGGCC------------------------------------------------- ------------------------------------ACAAGGCTACCTAGTCCGCATGCC CCCCCGGACCTAGGGTTTTGCACCCCAGAACAATGA------------------------ ------------------------------------------------------------ ---------------------------CCAGAGAGACAGTCATTTTGCCTCACCACCCTC CTGCGTGTCGCGCCTGAC-----------------------------------------A GCCGGCTGC------CCCAGCC--CCCCAGCGCCAGCATGACCACACTTACA-------- -----------------GCCAGG-------------------------------CCCCCT CAG------------------------TGCCCCGCCAGGCCCAGAGAGGGG--------- ------------AGTTGGTTCGCGACACTTCCAGT---------------------GTAC AACACTGGACCGGGTCTCTACCCATGCCCAAGGAGACATGCCACA-------------AC AGAGAGGTTC--CTTCCGGTCTCCCCGATGCAGGCAG----------------------- -------------------------------------CCTGGGCC--------------- -----ACTGACG------------------------------------------------ ------TGTCCGCCT--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TGACC ACCTATGTGGGT------------------------------CTCCCCCACAGCACCTGC ACTGCCCCC--------GCACCACCCATTGCATTCTTGGCCTGAGCCATCG--------- -------------------------------------------------CGCCTGTTTTG ACCGG-------------CTCCC------------------------------------- ------------------------------------------------------------ ----------CAGGCTCAGTTGCTA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GGAAAAGGTTTTCTCTTATA-----------------AAT T-----------TTGAAACAAGTCCCC--------------------------------- ------------------------------------------------------------ -------------------------------------AGAAGGATGGGCACA-------- ------------------------------------------------------------ -----------AACAAAGC----------------------CA----------------- ------------------------------------------------------------ --GACTGCAA-AGACTGAA----------------------------------------- ---ATAAATACCTAACTCTTC--------------------------------------- -----------------------------------AATGCGCAG---------------- ------ACATCGAT-------GTACATTCACA-------AGCATTAAGAACAATCAGGGA AATATGACCTCAC-----CAA------------ATGGACAAAACAAGGCG---------- CCAG---TGACCGACCCTA-------AAG-------AGAT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GGA-GATGTATG ATCT------GTCAGACA------AGGAA------------TTCAAAAT---AGCTGT-T TTAAGGA---AGCTCAGTGAACT----TCAAGAAAACA---------------------- ------------------------------CAGAGAAACAATTC-----AGAAAT----- ----------------------------------------T------------------- --TATCAGAAAAATTTAACAGAGAG---ATTGAAATATTAAAC----------------- ----------------------AAAAA-------------AAAA------AATAAAAAAA -------------------------------------TATATAAAAAAAT---------- -----CAAACAAAA---------------------------------------------- ------------------------TCTT-GGAGT---TGAAA---------AATTC---- -AATAAATGAA----TTAAAAAATACAATTG-------ACAG------------------ --------------------------------------------TGTCAATAACAAATC- -----TGATCTTAAAC------------------AAAAG---------AAAGAAAT-TTT TGAACTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACAGGTAAGTTGAAA-TATTAATAAT------CCAG-----------AG--- ------------------GGGTAAAAAAGATTTAAGA---ATAAAAAGGAA--------- TAA-AGAAAGCCTACAG--GACTCATGGG-ACACAATT-----------AAGCA--AACA AATATTTGCA-TTATAAG--GATGCCAGAGG-----------------GGGAAGAGATGA AGAAAGGCACAG---------AAAACTTATTTAA--C--------AAAATAATAGC-T-G AAAACTTTCCAAGTAT--------------------TGAGAGAGATATGG--ACATCCAG ATCC-----AGGAAGCTCAAAGATT---CCCAAT-TAGAT--------TCA--------- ---A-CCCAAAAA-----GATTCTCTCCAA----------------------------GG CACATTATAATCAAACT------GTC-AAAAG---------TCAAAGACA---------- ------------AAA--AGAGAATTC---------------------------------- --------TAAAAGCTGCAAGAGA---AAAGCATC--------------AAGTTAC---A TAT----------AAGA--------------GAATCTCTAT--TAGACTAT-C--AGCAG ATT--------TTTTAACAGAA--ATCTTG-CAAG--CCAG-GAAAGAATG--------- ----GGA-TGATATA-T-------TCAAAG--T-GCT-GAAAGAAAAA------------ -AAA-AC--TCA--AACAAGAA--------TATTAT----------ATCCA--------- --GCAAAGCTATCT-----TTTA-AAAATGA-------AGG-AGAAATAAAGACCTTCGC AGACAAGC-AAAAACTGAGGGA-ATTCATCACCACTATGC---TGGCCTTAC-AAGAAAT GCT--------------TAAAGG----------------------AGTGC---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------TACAACTGGAAGTGCTAATGTGTAACAAGAAAACATCTGAA GG---------------------------------------------------------- -----------TATAAAACTCACTGAAAGTAAGTATACAAACAAATTCAGAATACTCTAA TACTGTAATTGTGGTGTGTAAACCACTTATATCT---TTAGTATGAAGACT--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AAAAGACAAAACTATTAAAAA TAA--------------------------------------------------------- -----------------------------------TAATAACTACAATAATTTGTTAAGA GATAGGCTATAAAAAGATGTAAATTGGAAATTCAAAAATTCAAAATGTGGGGGGAAGGGA AGGTAAATGAAGGTG--------------------------------------------- ------------------------------------------TTTTTTTTTTTTTTTTTT TTGTTTTTTTTGTGATCAAAGTTAAGTTGTTATCAGCTTAAAATAACCTGTT-------- ----------------------------------ATAA---------------------- --CTATAAGAGTTTTTTGTAAGCCTCATGGTAACCACAAAGCAAAAATCTATAATAG--- ------------ATACACTAAAAATAAAAAGCAAG-----------GAATCAAAACATAC TACTAG------AGAAAATCACT----------------------TAAC-----CACAAA ----GG------AAGACAGTAAG--AGAGGA-------AGAAAG--------AAGAAAGA ATCTACAAAACAACTAGAAAACAAGTAAC---------------------------A--- ------------------------------------------------AATGGCA----- --------------------GTAGTAA--GTCC-TTACCTATCAATAA------------ -------------TTAC-CTTGAATG-TAAATGGATT--AAATTC---TCCAATTAAAAG ACATAGAG--TGGCTAAA-TGGAT------------AAAAAAAAAAGACCCAACTA---- ---TAT-GCTGCCTACAAGAG-ACTCACTT-CACCT--GTAAAGACACACATAGACTGAA AG--TGAAAGGA--AGGAAAA-AAAAATTTCATTGAAAAGG------AAAAC-------- -------------AAAAA-AAAGCAG--GAGTAGCTATACTTATATC-AGATAAAATAGA CTTTAAG-TC----------AA--------AAAATGAA--AAAA-AAGGCCATTATAT-- ----AATAATAAA---GGGATCAATTCAGC--AAGAGG--------AT-ATAACAATTAT AA-----------------ATATATATGCACCCAACATTGGAGCACCTAA--ATATATAA AGCAAATATTAATAGATCTAAAGGG------AGACTGCAATAC---------AATAATAG TAGGGGACTTCAACACCCCAC-----TTTCAACAATGGACAGA----------------- ----TCATCCAGAC------AGAA-----AATCAACAAAAAAAAAATAGAATTA------ --A---------------AAATGGAC-CTAACAG--ACATTTATAGAA--AATTCCATCC AACAACTA---TAGAATATACATTCTTCTCA-------ACTGCACAT---GGAACATTCT C------CAGGATAGATCATATGTTAGGCCACAAAACAAG-------------------- -TCTTAACAAATTTAAAAAAA--TCAAAAT----------------CATATCAA------ -GTATCTTTTCT---GACCACAATGGAA-TAAAACTAGAAATTAATAACA--------AG A-------------AA-AACTTTG---GAAACTTTACAA----ATACATGGAAATTAAAC AACATG-CTCCTGAA---CA-ACCAATG--GGTCA---ATAAAGAAAT--TAA-AAGGAA ATTAAAAAAATTTTTT---AAGAC------------------------AAATAAAAATGG AAAACACACA--ATACCAAAACCTA-TGG-GATACAGCAAAAGCAGTTCTAAGAGGGAAG --TTTATAGAAATAAATACCTAAATAAAAAAAA---AAAA--AAAATTA-------TAAA ------CAACCTAACAATGCACCTTAA---AGAACTAAAAAA---AA---AAAAAAAAAC TAAACCCA-AAATTAGTA------------GAAGAAAAGAAATAAT-AAAGATCAGAGCA GAAATA---AATAAAATAGAGACTAAAAAAA-------AAAAAAAAAAA-AAAAAAAAAA -AGAGT-------TTGTTTTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGACAAACCT---TTAGCTA------GACT-------------- AAGAAAAAAAAGA---------GAGA-AGACTCAAATAAA-------------------- -----TAAAA---T---------CAGAGATGAAAAA------GGAGA---CATTACAACT G--------ATAC-CACAGAAATA-CAAAGGATC--ATAAG---------AGACT----- -------------------ATTATGAACAA-CTATATGCCAACAA--AT---TGGAAAAC CTAG---AAGAAAT--GGATAAATTCCT--G---GACACA---------TAC-----AAC CTACCA------AGATTGAATCATGAAGAAATAGAAAATCTGAAC--------------- --------AGACCA------A------TAATGAGTAATGAAAT----TGAAT--CAGTAA -TAAAAAGTCTCCCATCAAAGAAAAG--CC-CAGGACC--TGATGGCTTCACTGCTGAA- TTCTA------------CCAAACATTT----AAAGAAGAACTAATA-CCAATT-----C- ----TTCTCAAACTATTCCAA-------AAAATTG-AAGAGGAGGG-----------AAT TCTTCCAAACTCATTCTATGAG---------GCCAGCAT---TACCCTGATACC--AAAA C-----------------------CAGAC--AAGGACA-CAAC----AA---------AA AAAGAAAACT---------------------ACA------GGCCAATAT--CCC----TG ATGAACATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGCAAAAATT------------------AAATT------------ ---A-AA--ACA-------------GCACATT---------AAAAAGATCATTCA--CCA ----TGAT------------CAAGTGGGA-TTCATCCCAGGGA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATGC----AAATCAATAAATGTG--ATA CATCAC---------A------TTAACAG----AATGAAGGACAAAAAC---CATATGA- ----TCATTTC---AATA----------GATGCAGA-AAAAG---CATTTGATAA---AA TTCAACATCCCTT-------------------CATGA---------T-AAAAAC-TCTCA --ACAAATTAGGTATAGAAGGAATAT-----ACCTCAACACAAT---------------- -----------AAAGGCCAT-ATAT-GACAAACCCACAGC-----------TAACAT--C ATACTGAATGGGGAAAA-G-----TTGAAAGC-TTTT---CCTCTAAGAT----CTGGAA CAAGACAAGGATGC-------CCACTTT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTTCTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATTAG------GCAAGAG---AAAGA--AATAAAAGGC ATCCAAATTGGAAA-------GGAGGAAGTCAAA--TTGTCCCTG-----TTTGCAGATG AC--ATGATCTTA-------TATATAGAAAACCCT---------------AAAGA---CT CCACCA---------AAA--AACTGTTAGAACT---------AATAAA--CAAATTCAGT AAAG--TT-------------------------GCAGGATACAA--------------AA TCAACAT------------ACAAAAAT----CAGTAGCATTTC--TA-TATGCTAA--TA GTGAACTATCTGA------------------AAAAGAAA-TCAAA----AAAACAATTCC ATTTAAAATTGC---CAAA----AAAATAAAATACCTAGGAATAAATTT--------AAC -CAAGGAGGTGAAAGATCTCT---ACAATGAA--AACTATAAAACATTGATG-AAAGAAA TTGAAGA-----------GA------------------ACAC--AAAT--AAATGGAAAA ATAT------A---TCATGTTTATA------TATTGGAAAAATT-----AATA-TTGTT- ------------------------AAAATGTCCA-TA-CTACCC-AA------------- ----AGTAATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------ACCAATG- AC------------ATTCTT---------------------------------------- --CACAGAAATAG---AAA------AAAAAATCCTAAAA-TTTTTATGGAA-------AC ACAAAAGACCCC---AA--ATAGCCAAAGCAATCTTGAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACA---CTACCTGACTTCAAAAT-----ATACTACAA---AGCT ATAGT-AACCAAAAC-AG------CATGGTACTGG--CA-----------------TAAA AACAGACA------CATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAT AAA---TCCATACATTTACA----GCCAAC--TGATTTTT---AACAAA--GGTGC--CA AGAACACAC--ATTGG-----GGAAAAA----ACAGT--------CTCTT--TAATAAAT GGTGCTG----------G-GAAAAT--TGG-A-TATCTA---------------AAAGC- AAA---------AAA--ATAAAACTAGACCCCT----ATCT---------------CTCA CC--ATATACAAAAA-TCAACT-CAAAATGGATTAAAGACTTAAATGTA--AGACCCAAA ACT-AT------------------------GAAACTACTAGAA----------------- ------GAAA--ACATA------G---------GGG---------AAATGCTTCATGAC- --ATT-----GG-TCTGGGCAAGGATTTTTTGAATAA-AACCTCA-AAA----GCACAGG CAACAAAAGCAAA----A------AT---AGAC--AAA-TGGGATTAC--AT-------- -------------------------------------------------------C-AAA CTAAAAAGCTT-CTGCA---CAGC-AAAGGAAACAATCAAC-AGAG-TGAAGAG-ACAAC CTAC--AGAA--T-GGGAG--AAAATATTT---GCAAACTATACAT--------CTGACA AGGGGTTAA-------TATCCAGAATATATA--AGGAA--CTCAA-----ACAAC----- ----------------------TCAAAAAAAA------AAAAAT------------A--- AAAAATATAA-TTAAAA----------AATGGGCAAA-----------AGA--CCTGAAT ---AGACATTTCTCAAAAGAAGACATACAAA--------------TGGCCAAC-AGGTAT ATGAAAAAATG----CTCAACATCACTAA-TCATCAGGGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TATCACCTCACCCCAGTTAGAATGGCTA-- ----TTATCAAAA-------AAAAA-----------AAAACAA--ATG--TTGGT-G--- ---------------AGGATATAGAGAA-------------------------------- -----AAGGGAACACTTAT-ACACTGTTGA--TGGGAA---------------------- -------------TGTA-------------AATTA-GTACAACC--------ATTAAGG- -------AAAACA-GTATGGAG--GTTC-CTCAAAAAATTAAAA--ATAGAACTACCA-- -TATGA--TCCAGCAATCCCACTACTGGG-TATATA-TCCAAAGGAAAT--G-------- -----------------------------------AAAGCAATCTG----------C--- ---------ACTCC--CATGTTTATTGCAGCACTATT---CACAATA-GCCAAGATAT-G GA--ATCA--ACCTAAG-TGTCCATCA---ATGGATG-----AATGGATAAA--AAAAAA TG---------------------------------------------------------- ---------------------TGTATATAT----ACACAATGGAATAC--TATTCA-GAC ATAAAA----------------------AAAAATGAAATCCTGTCATTT----------- ------------------------------------------------------------ -GTAACAACATGGATGAAC-C---T----------------GGAGGACATTATGTTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GGCAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAG---- -----------------------------ACAAATAC-TGCATG--------ATC----- ------TCACT---CAT------------------------ATGTGGAAAT---CTAAAA A-------A--------------GTTGAT---------------C--------------- ------------------------------------TCATA-------------GAAG-- -------TA------------------------------------------GAGAGT--- -AGAATAGTGGT---TACCA-----GAGGCTGGG---------GAGGGG----------- AGGGGGGAAGGG------------------------------------------------ --GGG-----ATGGGGAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGG---------------------TTG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GTCAATG---------------------------------------------- --------GGTA----CAAAGTTA------------------------CAGTTAGATAGG AGGAAT--------------------------AAGTTCTGGTGTTCTATTGC-------A CAG-----------------------------------------------------TAGG GTGACTATAGTT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACAATAATG-- ----------------------TATTGTATA--------TTTCAAAATAG---CTAGA-- -------------AGAGAGGATTTTGAATGTTCTCACCACAAAGAAATGATAAA------ ---------------------------------------TGTTTGAGGTGATGGATATGC TAATT-----ACCCTGATT------------------------------TGATCATTACA C-----AATG-TATACA-------------------------------TGTATT------ ------------------------------------------------------------ ----------------------------------------AAAACATCACAT---TGTAC CCCATAATATGTACAATTA------------TTATGTG----TCAATTAAA------AA- -------TAA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MA4 ----------------------GTACCTCTATTTCCAAAATG--GCAGCGT-AGAAGCAA TCTGGCTTCCC-----TTCCCA--------CCATCATTGACCGCCCCCCCGCCCCCCCCA GGAAAGCA-------------AAAA---------CAGGTACACAGCGGC--------AAC AT--TATCACCAGT------GCTGCCCCAGAAGTCAAATCTGAG-----------GCTG- -AGA---CAGTTCCTGGG-------------------------------GTCACAGGGAA ----------------------GCGAAAAAACAAAACCAAATGACC-------------- ------------TCTGAACTG--------------------------------------- -------------------------------------------------------GTCGT AAGTGACTCAGACTTC---------------------TATATCT-CTGACGCCCCTTCCC C-------------------------CTAATCTGGCTGTCAGCAAGCACA--------TG GAAAATTTCCCCCCAACT---CCC------------------------------------ --------------------------------------------------------GGTT TCCCCCTTGAAAAAGGTGAGA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------TTAAGGCGGACAAC CAGCTTTCCCACCA-TCTTGGGGT------------------------------------ -----CCTCGGCATGAGACCTGTCC----------------------------------- ------------------------------------CTGCCTCAA--------------- -------------------CCCACGGGAAGCATCATGAGTGGCTCTAGG----------- ----------------------------------------GAGAAATATTCCTGAGG--- ------------------------------------------------------------ --------------------ACAGCCAGA--------------GAAAAAGGGGGGG---- -------------------GGTGGGACTACCAT--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CCCCAGCCCCGGAAA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------CTCTGCT--CTGTAACTTGG------------------------- --------------------------------------------------------CCAC TGG--------------------------AGACGCCAAATC------------------- ------------AGAGTGG--------CTGTTCAG------------------------- --------------CAGCACCAC-----------------------------------AC TGTAGGACACTTGTTCCA------------------------------------------ -------------------------------------CAGGTCCCCTGG----------- -----GCACGAACACCTAGCCAGCCTTCCCAAACTGCCCGGC------------------ ------TGTCCCCTTTGGAT---------------------------------------- ------------------------------------------------------------ -------------------------------------------------------CCCCC ACCATTCAGGATGGGCAGCGACTG------------------ATGGTTTACAAAATTATC ACTCACATCAACAAGCTGCGCTACTGATGTTTGCCAGAGCCACGGCAAACC--------- ------------TGGGCTTAGGG------------------------------------- ------------------TGCCA------------------------------------- ----------------------------------------------TCTAGTGCTAAAAA G---GAGGCACCGACCCCGCGG-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAAAAAA------------------------------ACG C-----------AAAAAAATCCACCCCGTATA---------------------------- ------------------------------------------------------------ -----TTAGACACAATATCTATGG----AAAGATATGCAAAAAACAGCACCAC------- ------------------------------------------------------------ -----------AAAAACCC----------------------------------------- ------------------------------------------------------------ --ATACTGAAAAGAGTGGA----------------------------------------- ---ATAAATACCTAATCCTTC--------------------------------------- -----------------------------------AATGCACAG---------------- ------ATATTGAT-------GTACATCCACA-------AGAATCAAGAAGAAACAGGGA AACATGACCTCCC-----CAA------------ATGGACAAAACAAGGAA---------- CCAG---TGACTGACCCTA-------ATG-AGA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TAAAGATATGTG AGCT------CTCTGACA------AAGAA------------TTCAAAAT---AGCAGT-T TTAAGGA---AACTCAGTGAACT----CCAAGATAACA---------------------- ------------------------------CAGAAAAGCAATTC-----AGAAAT----- ----------------------------------------T------------------- --TATCAGGGAAATTTAACAAAGAG---GTTGA--------------------------- ----------------------------------------ATAA------AAT------- --------------------------------------TTAAAAAA-------------- -----TCAAACAAAA--------------------------------------------- ------------------------TCTT-GGAAC---TGAGA---------AATAC---- -AATTACTGAA----CTGAAAAATTCATTAG-------AGGC------------------ --------------------------------------------TCTCAACAGCAGAAT- -----GGATC--AAGC------------------AGAGG---------AAAG-AAT-CAG TGAGCTC----------------------------------------------------- ------------------------------------------------------------ ----AAAGACAGGCTATTTGAAAAT---ACACAG------TCAG---------AAAA--- ------------------ACAAAAAAAAAAAAAAAAAAAAATAAAAAGAAA--------- TGA-AAAAAACTTACAA--GATATAGAAA-ATAACCTC-----------AAAAG--ACCA AATCTAAGAA-TTATTGG--TGTTCAAGAGG--------------G---AGTTGAGCAAG AGCAAAGGGTAG---------AAAGCTTATTCAA--A--------GAAATAATAAC-A-G AAAACTTTCCAAAACT--------------------TGAGAAAGATATAA--ATATCCAG GTAC-----AGGAAGGTCAGAGAAC---ACCAAA-CAGAT--------TCA--------- ---A-CCCAAATA-----AGACTACCCCAA----------------------------GG CATATAATAATCAAACT------CTC-AAAGG---------TCAAGGACA---------- ------------AAG--AGAGGATTC---------------------------------- --------TAAAAACAGCAAGAGA---AAAAAAGC--------------AAATAAC---A TAT----------AAAG--------------GAGCTCCAAT--TCATCTGG-C--AACAG ACT--------TCTCAACAGAA--ACCATA-CAGG--CCAG-GAGAGAGTG--------- ----GAA-TGACATA-T-------TTAAAG--T-GCT-GAAAAAAAAA------------ -AAC-TG--CCA--TCCAAGAA--------TACTTT----------ATCCA--------- --GCAAAGCTATCC-----TTCA-AATATGA-------AGG-AGAGATAAAGTCTTTCCC AGACAAAC-AAAAGCTGAGAGA-ATTCATCACCACCAGAC---CTGTCTTAC-AAGAAAT GCT--------------AAAGGG----------------------AGTTC---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------TTCAATCTGAAAAAAAAAAAAAAGTAACAACCAAAAAGAAACTATATGAA GGTGACACTAATGTGCAACAAGAAAACATCTGAAGGTATAAAACTCACTGGTAAAAGTAA GTACA------TAGAC----------AAGGAAAAAGCAAGAAAAATCAAGAATATTCTAA TACTGTAATTGTGGTGTGTAAACCACTCATATCT---TTAGTATGAAGACT--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AAAAGACAAATCTATCAAAAA AAAATAATAACTACAACA------------------------------------------ ----------------------------------------------ACTTGTTAAGAGAT AGGCAATTATAAAAATATATAAATTGAGACAACAAAAAGTCAAAATGATGGTGAACGTGG GGGGGATGGAGTTAA-----------------------------------AGTGTAGAGT TTTTTTGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCTTTTTTTTTTTTTCTTTGTTTCC ATTCTAAATTTGTGATCAAAGATAAGTTGTCATCTCTTTAAA------------------ ----------------------------------ATAA-------------CTTGTTATA ACTATAAAATTTTTTTTGTAAGCCTCATGGTAACCACAAAGCAAAAACCTATAATAGATA CACT----------------AAAAATAAAAACAAG-----------GAATTAAAACATAC TACCAG------AGAAAATCACC----------------------TAAC-----CACAAA ----GG------AAGACAGTAAG--AGAGGA-------AGAAAGG-------AAGAGAGG AGTTACAAAACAACCAGAAAACAAGTAAC---------------------------A--- ------------------------------------------------AATGGCA----- --------------------GTAGTAA--GTCC-TTACTTATCAATAA------------ -------------TAAC-ATTGAATG-TAAATGGACT--AAATTC---TCCAATTAAAAG ACATAGAG--TGGCTGAA-TGGAT------------AAAAAAAAAAAACCAAATAA---- ---TTT-GTTCCTTAAAAAAA-ACCCCTTT-CCCTT--ATAAGAAACCCAATAGAATGAA AA--TTAAGGGG--TGGAAAA-AAATATTTCATGCAAATGG------AA----------- -------------AAAAA-AGAGCAG--GAGTAGCTATACTTATATC-AGATAAAATAGA CTTTAAG-TC----------AAAAACTGTAAAAAGAGAC-AAAG-AAGGTCATTATAT-- ----AATGATAAA---GGGGTCAATTCAGC--AAGAGG--------AT-ATAACAATTAT AA-----------------ATATATATGCACCCAACACTGGAGCACCCAA--ATATATAA AGCAAACATTAATAGATCTAAAGGGAGAGATAGACTGCAATAC---------AATAATAG TAGGGGACTTCAACACCCCAC-----TTTCAGTAATGGACAGA----------------- ----TCATCCAGAC------AGAA-----AATCAACAAAGAAACATTGGAGTTA------ --AACTACACACTAGACCAAATAGGC-CTAACTG--ACATTTACAGAA--CATTTCATCC AACTGCTG---CAGAATACACATTCTTCTCA-------TCAGCACAT---GGAACATTCT C------CAGGATAGACCATATGTTAGGCCACAAAACAAG-------------------- -TCTCAACAAATTTAAAAAAA--TAAAAAT----------------CATATCAA------ -GTATCTTTTCT---GACCACAATGGAA-TAAAACTAGAAATCAATAACA--------AG A-------------GG-AACTTTG---GAAACTATACAA----ATACATGGAAATTAAAC AACATG-CTCCTGAA---TG-ACCAATG--GATCA---ATAAAA------TAA-AAAGAA AATTTAAAAATTTCTT---GAAAC------------------------AAATGAAAATGG -AAACACAAA--ATACCAAAAACCT-TAGGGAAAAAACAAAAGCAGTACTAAGAAGGAAG --TTTATAGCAATAAATGCCTACATCAAAAAAG---TAGA--AAGACTT---CAAATAAA ------CAACCTAATGATGCACCTCAA---GGAACTAGAAAA---GC---AAGAACAAAC CAAACCCA-AAATTAGTA------------GAAGAAAAGAAATAAT-AAAGATCAGAGCA GAAATA---AATGAAATTGAGACTAAAAAAA-------TAAAAAAAATC-AATAAAATAA -AAAGT-------TGGTTTTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTAACAAACCT---TTAGCTA------GACT-------------- AACAAAAAAAAAA---------GAGA-AGACCCAAATAAA-------------------- -----TAAAA---T---------CAGAAATGAAAAA------GGAGA---CATTACAACT G--------ATAC-CACAGAAATA-CAAAGGATC--ATTAG---------AGACT----- -------------------ATTATGAACAA-CTATATGCCAACAA--AT---TGGAAAAC CTAG---AAGAAAT--GGATAAATTCCT--G---GACACA---------TAC-----AAC CTACCA------AGATTGAACCATGAAGAAATAGAAAACCTGAAC--------------- --------AGACCA------A------TAATGAGTAATAAGAT----TGAAG--CAGTAA -TAAAAAGTCTCCCATCAAAGAAAAG--CC-CAGGACC--TGATGGCTTCACTGCTGAA- TTCTA------------CCAAACATTT----AAAGAAGAACTAATA-CCAATT-----C- ----TACTCAAACTATTCAAA-------AAAATTG-AAGAGGAGGG-----------AAT ACTTCCAAACTCATTCTATGAG---------GCCAGCAT---TACCCTGATACC--AAAA C-----------------------CAGAC--AAAGACA-CAAC----------------A AAAAAAAACT---------------------ACA------GGCCAATAT--CAC----TG ATGAACATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACAA------------------AA--T------------ ---T-CA--ACA-------------ACACATT---------AAAAAGATCATTCA--CCA ----TGAT------------CAAGTGGGA-TTCATCCCAGGGA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATGC----AAATCAATAAATGTG--ATA CATCAC---------A------TTAACAG----AATCAAGGACAAAAAC---CATATGA- ----TCATTTC---AATA----------GATGCTGA-AAAAG---CATTTGATAA---AA TTCAACATCCCTT-------------------TATGA---------T-AAAAAC-TCTCA --ACAAACTGGGTATAGAAGGAACAT-----ACCTCAAAATAAT---------------- -----------AAAGGCCAT-ATAT-GACAAACCCACAGC-----------TAACAT--C ATACTGAATGGGGAAAA-A-----TTGAAAGC-CTTT---CCTCTAAGAT----CTGGAA CAAGACAAGGATGC-------CCACTTT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTTTTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATTAG------GCAAGAG---AAAGA--AATAAAGGGC ATCCAAATTGGAAA-------GGAAGAAGTCAAA--TTATCCTTG-----TTTGCAGATG AC--ATGATCTTA-------TATTTAGAAAAACCT---------------AAAGA---CT CCACCA---------AAA--AACTGTTAGAACT---------GATAAA--TAAATTCAGT AAAG--TT-------------------------GCAGGATACAA--------------AA TCAACAT------------ACAAAAAT----CAGTAGCATTTC--TA-TATACCAA--CA GTAAACAATCTGA------------------AAAAGAAA-TCAAG----AAAGCAATCCC ATTTACAATAGC-TACAAA---AAATATAAAATACCTAGGAATAAATTT--------AAC -CAAAGAAGTGAAAGATCTCT---ACAAGGAA--AACTATAAAACACTGATG-AAAGAAA TTGAAGA-----------GG------------------ACAC--AAA---AAAAGGAAAA ATTT------TC--CAATGTTCATG------GATTGGAAGAATT-----AATA-TTGTT- ------------------------AAAATGTCAA-TA-CTACCC-AA------------- ----AGCAATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------ACCAATG- AC------------ATTCTT---------------------------------------- --CACAGAAATAGA--AAA------AAAAAATCCTAAAA-TTTATATGAAA-------CC ACAAAAGACCC----AA--ATAGCCAAAGCAATCCTGAGCAAAAAGAACA---AAGC--T -------GGAGGCATCACA---CTACCTGACTTCAAAAT-----ATACTACAA---AGCT ATAGT-AACCAAAAC-AG------CATGGTACTGG--CA-----------------TAAA AACAGACA------CATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAT AAA---TCCACACATTTACA----GCCAAC--TCATTTTT---GACAAA--GGCGC--CA AGAACATAC--ATTGG-----GGAAAGG----ACAGT--------CTCTT--CAATAAAT GGTGCTG----------G-GAAAAC--TGG-A-TAACCA---------------ATTGC- AGA---------AGA--ATGAAACTAGACCCCT----ATCT---------------CTCA CC--ATATACAAAAA-TCAAAT-CAAAATGGATTAAAGACTTAAATCTA--AGACCTGAA ACT-AT------------------------GAAACTACTAGAA----------------- ------GAAA--ACTTT------G---------GGG---------AAACGCTCCAGGAC- --ATT-----GG-TCTGGGCAAAGATTTTTTGGGTAA-GACTTCA-AAA----GCACAGG CAACAAAAGCAAA----A------AT---AGAC--AAA-TGGGATTAC--AT-------- -------------------------------------------------------C-AAG CTAAAAAGCTT-CTGCA---CAGC-AAAGGAAACAATCAAC-AAAG-TGAAGAG-ACAAC CTAC--AGAA--T-GGGAG--AAAATATTT---GCAAACTATCCAT--------CTGACA AGGGATTAA-------TAACCAGAATATATA--AGGAA--CTCAA-----ACAAC----- ----------------------TCAATAGCAA------AAAAAA------------A--- AATAATCTAA-TTATAA----------AATGGGCAAA-----------AGA--TCTGAAT ---AGACATTTCTCAAAAGAAGACATACAAA--------------TGGCCAAC-AGGTAT ATGAAAAAATG----CTCAACATCACTAA-TCATCAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TATCATCTCACCCCAGTTAAAATGGCTT-- ----TTATCAAAA---AGACAAAAA---------ATATAACAA--ATG--CTGGT-G--- ---------------AGGATGTGGAGAA-------------------------------- -----AGGAGAACTCTTAT-ACACTGTTGG---GAAAG---------------------- -------------TAAA-------------AATTG-GTACAGCC--------ACTATGG- -------AAAACA-GTATGGAG--GTTC-CTCAAAAAATTAAAAATATAGAACTACCA-- -TATGA--TCCAGCAATCCCACTACTGGG-TATATA-TCCAAAAA-AAA--GAAA----- -------------------AAAAATAT-ATATA--AAAGATATCTG----------C--- ---------ACTCC--CATGTTTATTGCAGCACTATT---CACAATA-GCCAAGATAT-G GA--ATCA--ACCTAAG-TGTCCATCA---ATGGATG-----AATGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTATATAT----ACACAATGGAATAT--TATTCA-GCC ATAAAA----------------------AAGAATGAAATCCTGTCATTT----------- ------------------------------------------------------------ -GCAGCAACATGGATGGAA-C---T----------------GGAGGTCATTATGTTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GGCAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAG---- -----------------------------ACAAATAT-CACATG--------TTC----- ------TCACT---CAT------------------------ATGTGGG------CTAAAA A-------A--------------GTGGAT---------------C--------------- ------------------------------------TCATG-------------GAGG-- -------TA------------------------------------------GAGAGT--- -AGAATGGTGGT---TACCA-----GAGGCTGGG---------AAGGGT----------- AGGGGGGGGGAG------------------------------------------------ --GGG-------AGGATG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AAG----------------AGAGGTTG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GTTAATG---------------------------------------------- --------GGTA----CAAAAATA----------------------------CAGATAGA AGGAAT--------------------------AAGTTCTAGTGTTTGATAGT-------A CAG-----------------------------------------------------TAGG GTGACTATAGTT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACAATAATT-- ----------------------TATTGTATA--------TTTCAAAATAG---CTAGA-- -------------AGAGAAGAATTGGAATGTTCCCAACACAAAGAAAAGATAAA------ ---------------------------------------TGTTTGAGGTGATGGATATCC CAATT-----ACCCTGATT------------------------------TGATCATTACA C-----ATTG-TATGCA-------------------------------TGTATC------ ------------------------------------------------------------ ----------------------------------------AAAATATCACAT---GTACC CCAAAAATATGTACAACTA------------TTATGTA----TCAATAAAA------AA- -------A---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MA3 ---------------------GGGGGGAGGCAGAGCAAGATG--GCCGAAT-AGAAGCCT CCACCAATCAT----CCTCCCT--------ACAGGAACACCAAATTGAACAACTATCCAC AAAAAAGCACCTTCATAAGAACCAA---------AAATCAGGTGA-------------GT GA--TCACAGTACCT-----GGTTTTAACTTCATATCACTGAAA-----------GAGGC ACTG---AAGAGGGTAGGAAAGACAGTCTTGAATT--------------GCCGACGCCAC C----------------------------------------------------------- ------------CCTCCCCCA-----------TCCCCTGGCAGTGGCCGCATGGCGTGG- -------------AGAGAGAATCTGTGTGC----TTGGGGGAGGGAG-----AGCGCAGT GATTGTGGGACTTTGC------ATTGGAACTCAGTGCTGCCCTG-TCACAGTGGAAAGCA ACACTGGGCAGAACTCAGCCAGTGCCCACGGAGGGAGCATTTAGACCAGCCCTAGCCAGA GGGGAATCACCCATCCCAGCGGTT------------------------------------ ---GGAACCTGAGTTCTGGCAAGCCTCGCCACTGCGGGCTAAAGTGCTCTGGGGTCCTAA ATAAACTTGAAAGGCAGTCTA---------GGCCACAAGGACTGCAATTCCTGGG----- ------------------------------------------------------------ --------------------CAAGTCCTGGTGCTGTGCTGGGCTCAGAGCCAGTGGACTT GGGGGGCACATGA-------------CCTAGTGAGACACCAGCCGGGGTGGCCAAGGGAG TGCTTGCGCCACCC-CTCCCCCAACCCCAGGCAGCACAGCTCG----------------- ---CAGCTCCAGGAGAGACTCCTTCCTTCTGCTTGAGGAGAGGAGAGGGAAGAGTAAAGA GGACTTTGTCTTGCAACTTGGATACCAGCTCAGCCACAGTAGGATAGGGCACCAGGCAG- -------------------AGTCCTGAGGCCCCCATTCCAGGCCCTAGCTCCCGGACGAC ATTTCTAGACACACCCTGGGCCAGAAGGGA----------ACCTGCTGCCTTGAAGG--- ---------------------------------------------GAAGGACCCAGTCCT GGCAGGATTCATCACCTGCTGACTAAAGA--------------GCCCTTGGGCCCTGAAT AATCAGCAGTGGTACCCAGGCAGTACTTGCCGTGG----------------GCCTTGGGT GA-------------GACTCAGAGACGTG----CTGGCTTCAGGTGTGACCCAGCACATT CCCAGCTGTGGTG---------------GCTATGGGGAGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ACTCCTTCTGCTTGA------------------GGAAAGGA GAGGGAAGAGTAAAGGGGACTTTGTCTTGCAGCTTAGGTACCAGCTTGGCCACAGTGGGG TAGAGCACCAAGCGGGCTCTTGGGGTCCCTGATTCCAGGCCTTGGCT----CTTGGATGG CATTTCTGGACCTGCCCTGGGCCAGAGGGGAGCCCA------------------CTGCCC TGAAGGGAGAGTCCCAGGCCTGGCAGCATTCACCACA----------------------- ---------------------------AGCTGACTGAAGAGCCCTTGGGCCTTGAGTGAA CATTGGTGGTAGCCAGGCAG---------------------------------------- ---------------TACTCGC--CACGGGCCTGGGGTGGTGGTGGCCACGGGGAGAGAC TCCTCTGCTTGTGGAAAGGGGAG--------------GGAAGAGTGGGAAGGACTTTGTC TTG--------------------TGGCTTGGGTGCCAGCTCAGCCACAGTAGAAT----- ------------AGAGCACCAGGTAGATTCCTAAGGT-------------------TTCT GACTCCAGGCC---CTGGCTCCTGGATGGC-----ATCTCTGG---------------AC CCACCTGGGG--CCAGGGGGAACTTGCCACCCTGAAGGGAAGGACACAAGCCTGGCTGGC TTTGCCACCTGCTGATTGTAGAGCCCTAGGGCC----TTGAGTGAACATAGGTGGTAGCC AGGCAGTGGTTACTGCAGGCCTTGGGTGAGACCCAGTGCTGT------------------ ------GCTGGCTTCAGGTCTGACCCAGCACAGTCCCAGTGGTGGTGGCCACAGGGGTGC TTGTGTCACCCCTCCCCCAGCTCCAGGCAGCTCAGCACAGAGAGAGACTCCATTTGTTTG GGGGAAAGTAAGGGAAGAGAA----------------------------------CAAGA GTCTCTGCCTGGTAATCCAGAGAA---------------------TTCTTCTGGATCTTA TCCAAGACC----------ACCAAGGTGGTACCTCTATGAGTCTGCAAGAG--------- CCACAGCGTTACTGGGCTTGGGG---------------------------------TGCC CCCTA-------------ATGCAGATATGGCTGCAG------------------------ -------------------------------------------TGACCAAAAACTTAG-- A---TCACAACACCCAAGTCCCTTT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAAT---------------------------------ACC T-----------GGAAAGCCT--------------------------------------- ------------------------------------------------------------ --------------------------------TCCCAAGAAGGATGGGTACA-------- ------------------------------------------------------------ -----------AACAAGCC----------------------CA----------------- ------------------------------------------------------------ --GACTGTGA-AGACTACA----------------------------------------- ---ATAAATACCTAACTCTTC--------------------------------------- -----------------------------------AATGCCCAG---------------- ------ACACTGAT-------GAACATCCACA-------AGCATCAAGACCATCCAGGAA AACATGACCTCAC-----CAA------------ATGAACTAAATAAGGCA---------- CCAG---GGACCAATCCTG-------GAG-------AGAC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGA-GATATGTG ACCT------TTCAGACA------GAGAA------------TTCAAAAT---AGCTGT-T TTGAGGA---AGCTCAATGAAAT----TCAAGATAACA---------------------- ------------------------------CAGAGAAGGAATTC-----AGAATC----- ----------------------------------------C------------------- -----------------------TA---TCAGATAAATT--------------------- ----------------------TAACA-------------AAGA------GATTGAAATA --------------------------------------ATTAAAAAGAAT---------- -----CAAGCAAAA---------------------------------------------- ------------------------TTCT-GGAGT---TGAAA---------AATGC---- -AATTGATATA----CTGAAGAATGCATCAG-------AGTC------------------ --------------------------------------------TCTTAATAGCAGAAT- -----TGATC--AAGC------------------AGAAG---------AAAG-AAT-TAG TGAGCTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACAGGCTATTTGAAA-A--TACACAG------TCAG---------AGGA--- ------------------AACAAAAGAAAAA---AGA---ATAAAAAAGAA--------- TGA-AGCATGCCTACAA--GATCTAGAAA-ATAGCCTC-----------AAAAG--GGCA AATCTAAGAG-TTATTGG-----CCTTAAAG--------------AGGAGGTAGAGAGAG AGATCGGGGTAG---------AAAGTTTATTCAA--A--------GGGATAATAAC-A-G AGAACTTTCCAAACCT--------------------AGAGAAAGATATCA--ATATTCAA GTAC-----AAGAAGGTTATAGAAC---ACCAAG-CAGAT--------TTA--------- ---A-CCCAAAGA-----AGACTACCTCAA----------------------------GA CATTTAATAATCAAACT------CCC-AAAGG---------TCAAGGATA---------- ------------AAG--AAAGGATCC---------------------------------- --------TAAAAGCAGCAAGAGA---AAAGAAAC--------------AAATAAC---A TAC----------AATG--------------GAGCTCCAAT--ATGTCTGG-C--AGCAG ACT--------TCTCAGTGGAA--ACCTTA-CAGG--CCAG-GAGAGAGTG--------- ----GCA-TGACATA-T-------TTAAAG--T-GCT-GAAGGAAAAA------------ -AAC-TT--TTA--TCCTAGAA--------TAGTAT----------ATCCA--------- --GTGAAAATATCC-----TTCA-AACATGA-------AGG-AGAAATAAAGACTTTCCC AGACAAAC-AAAAGCTGAGGGA-TTTCATCAACACCAGAC---CTGTCCTAC-AAGAAAT GCT--------------AAAGGG----------------------AGTTC---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------TTCAATCTGAAAGAAAAAGGATATTAATGAGCAATAAGAAATCATCTGAA GGTAAC------------------------------------------------------ -----------AAAACTCACTGGTAATAGTAAGTACACAGAAAAACACAGAATATTATAA CACTGTAATTGTGGTGTGTAAACTACTCATATCT---TGAGTAGAAAGACT--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AAAAGATGAACCTATCAAAAA TAATAACTA--------------------------------------------------- ----------------------------------------------CAACAACTTTTCAA GACATAGTATAATAAGATATAAATAGAAACAACAAAAAGTTAAAAAGCGGGGGGATGAAG TTAAAGTGTAGAGTT--------------------------------------------- -------------------------------TTTATTAGTTTTCTCTTTGCTTGTTTGTT AGTTTGTTTATGCAATCAGTGTTAAGTTGTCATCAGTTTAAAATA--------------- ----------------------------------ATGG---------------------- GTTATAAGATATTATTTGCAAGCCTCATGGTAACCTCAAATCAAAAAACATACAACAG-- ------------ATACACAAAAAATAAAAAGCAAG-----------AAATTAAAACATAC CACCAG------AGAAAATCACC------T---------------TCAC-----TAAAAG ----GA------------AGACAGGAAGGAA-------GGAAAGAAG-----GAAGAGAA GACCACAAAACAACCAGAAAACAAATAAC---------------------------A--- ------------------------------------------------AATGGCA----- --------------------GGAGTAA--GTCC-TTACTTATCAATAA------------ -------------TAAC-ATTGAATG-TAAATGGACT--AAACTC---TCCAATCAAAAG ACATAGAG--TGGCTGAA-TGGAT------------AAAAAAAAAAGACCCAATGA---- ---TCT-GTTGCCTACAAGAA-ACACACTT-CACCT--ATAAAGACACACATAGACTGAA AA--TAAAGGGA--TGGAAAA-AGATATTCCATGCCAATGG------AAACC-------- -------------AAAAA-AGAGCAG--GAGTAGCTATACTTATATC-AGACAAAATAGA TTTCAAG-AC----------AAAAACTATAAAAAGA----AAAG-AAGGTCATTATAT-- ----AATGATAAA---GGGGTCAATTCAGC--AAGAGG--------AT-ATAACAATTAT AA-----------------ATATAAATGCACCCAACACTGGAGCACCCAG--ATATATAA AGCAAATATTATTAGAGCTAAAGAGAGAGATAGACCCCAATAC---------AATAATAG CTGGAGACTTCAACACCCCAC-----TTTCAGCATTGGACAGA----------------- ----TCATCCAGAC------AGAA-----AATCAACAAAGAAACATTGGACTTA------ --ATCTGCACTATAGACCAAATGGAC-CTAATAG--ATATTTACAGAA--CATTTCATCC AATGGCTG---CAGAATACACATTCTTCTCC-------TCAGCACAT---GGATCATTCT C------AAGGATAGACCATATGTTAGGCCACAAAACAAG-------------------- -TCTTAAAAAATTCAAAAAAA--TTGAAAT----------------AATATCAA------ -GTATCTTCTCT---GACCACAATGGAA-TAAAACTAGAAATCAATAACA--------AG A-------------GG-AATTTTG---GAAACTATACAA----ACACATGGAAATTAAAC AATATG-CTCCTGAA---TG-ACCAGTG--GGTCA---ATGAAGAAAT--TAA-GAAGAA AATTGAAAAATTTCTT---GAAAC------------------------AAATGATAATGG -AAACACAAC--ATACCAAAACCTA-TGG-GATACAGCAAAAGCAGTACTAAGAGGGAAG --TTTATAGCTATAAGTACCTACATCAAAAAAG---TAGA--AAAACTT---CAAATAAA ------CAACCTAATGATGCATCTTAA---AGAACTAGAAAA---GC---AAGAGCAAAC CAAACCCA-AAATTAGTA------------GAAGAAAAGAAATAAT-AAAGATCAGAGCA GAAATA---AATGAAATTGAAATGAAAAAAA-AAA---TACAAAAGATC-AATGAAACAA -AAAGT-------TGGTTTTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGACAAACCT---TTAGCCA------GACT-------------- ---AAAAAAAAAAAG---A---GAGA-AGACCCAAATAAA-------------------- -----TAAAA---T---------CAGAGATGAAAAA------GGAGA---CATTACAACT G--------ATAC-CACAGAAATT-CAAAGGATC--ATTAG---------AGGCT----- -------------------ACTATGAGCAA-CTATATGCCAATAA--AT---TGGAAAAC CTAG---AAGAAAT--GGATAAATTCCT--A---GACACA---------TAC-----AAC CTACCA------AGATTGAACCATGAAGAAATCCAAAACCTGAAC--------------- --------AGACCA------A------TAACAAGTAATGAGAT----TGAAG--CCATAA -TAAAAAGTCTCCCAGCAAAGAAAAG--CC-CAGGACC--CAATGGCTTCACTGCTGAA- TTTTA------------CCAAACATTT----AAAGAAGAACTAATA-CCAATC-----C- ----TACTCAAACTATTCCAA-------AAAATAG-AGGAGGAGGG-----------AAT ACTTCCAAACTCATTCTATGAG---------GCCAGTAT---TACCCTGATACC--AAAA C-----------------------CAGAC--AAAGACA-CATC----AA---------AA AAAGAAAACT---------------------ACA------GGCCAATAT--CCC----TG ATGAACATTGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACCA------------------AA--T------------ ---T-CA--ACA-------------ACACATT---------AAAAAGATCATTCA--TCA ----TGAC------------CAAGTGGGA-TTTATCCCAGGGA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATGC----AAATCAATCAATGTG--ATA CATCAT---------A------TCAACAG----AATGAAGGACAAAAAC---CATATGA- ----TCATTTC---AATT----------GATGCTGA-AAAAG---CATTTGATAA---AA TTCAACATCCCTT-------------------CATGA---------T-AAAAAC-CCTCA --AAAAACTGGGTATAGAAGGAACAT-----ACCTCAACATAAT---------------- -----------AAAAGCCAT-ATAT-GACAGACCCACAGC-----------TAGTAT--C ATACTGAATGGGGAAAA-A-----CTGAAAGC-CTTT---CCTCTAAGAT----CTGGAA CAAGACAAGGATGC-------CCACTTT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTGTTATTCAA-CATA--GTACT---GGAAG TCCTAGCTAG--------AGCAATCAG------ACAAGAG---AAAGA--AATAAAGGGC ATCCAAATTGGAAA-------GGAAGAAGTCAAA--TTATCCTTG-----TTTGCAGATG AT--ATGATCTTA-------TATTTGGAAAAACCT---------------AAAGA---CT CCACCA---------AAA--AACTATTAGAACT---------GATAAA--CAAATTCAGT AAAG--TT-------------------------GCAGGATACAA--------------AA TCAACAT------------ACAAAAAT----CAGTAGCATTTC--TA-TATGCCAA--CA GTGAACAATCTGA------------------AAAAGAAA-TCAAG----AAAGTAATCCC ATTTACAATAGC-TACAAA---TAAAATAAAATACCTAGGAATTAACTT--------AAC -CAAAGAAGTGAAAGATCTCT---ACAATGAA--AACTATAAAACATTGATG-AAAGAAA TTGAAGA-----------GG------------------ACAC--AAAA--AAATGGAAAA ATAT------T---CCATGTTCATG------GATTGGAAGAATC-----AATA-TTGTT- ------------------------AAAATGTCCA-TA-CTACCC-AA------------- ----AGCAATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------ACCAATG- AC------------ATTCTT---------------------------------------- --CACAGAAATAG---AAA------AAACAATCCTAAAA-TTTATATGGAA-------CC ACAAAAGACCCA---GA--ATAGCCAAAGCTATCCTGAGCAAAAAGAACA---AAAC--T -------GGAGGAATCACA---TTACCTGACTTCAAATT-----ATACTACAG---AGCT ATAGT-AACCAAAAC-AG------CATGGTACTGG--CA-----------------TAAA AACAGACA------CATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAT AAA---TCCATACATCTACA----GTGAAC--TCATTTTT---AACAAA--GGTGC--CA AGAACATAC--ATTGG-----GGAAAGG----ACAGT--------CTCTT--CAATAAAT GGTGCTG----------G-GAAAAC--TGG-A-TATCCA---------------TATGC- AGA---------AGA--ATGAAACTAGACCCCT----ATCT---------------CTTG CC--ATATACAAAAA-TCAAAT-CAAAATGGATTAAAGACTTAAATCTA--AGACCTCAA ACT-AT------------------------GAAACTACTAAAA----------------- ------GAAA--ACATT------G---------GGG---------AAACTCTCCAGGAC- --ATT-----GG-ACTGGGCAAAGATTTCTTGAGTAA-TACCCCA-CAA----GCACAGG CAACCAAAGCAAA----A------AT---GGAC--AAA-TGGGATCAC--AT-------- -------------------------------------------------------C-AAG TTAAAAAGCTT-CTGCA---CAGC-AAAGGAAACAATCAAC-AAAG-TGAAGAG-ACAAC CCAC--AGAA--T-GGGAG--AAAATATTT---GCAAACTATCCAT--------CTGACA AGGGATTAA-------TAACCAGAATATATA--AGGAG--CTCAA-----ACAAC----- ----------------------TCTATAGGAA------AAAAAA------------TTCT AATAATCTAA-TTAAAA----------AATGGGCAAA-----------AGA--TCTGAAT ---AGACATTTCTCAAAAGAAGACATACAAA--------------TGGCAAAC-AGGTAT ATGAAAAGGTG----CTCAACATCATTGA-TCATCAGAGA-AAT--GCAAATC-AAAACT ACAATGAGA---------------------TATCATCTCACCCCAGTTAAAATGGCTT-- ----TTATCCAAA---AAACAGGCA-----------ATAACA---ATG--CTGGT-G--- ---------------AGGATGTGGAGAA-------------------------------- -----AAGGGAACCCTTGT-ACACTGTTGG--TGGGAA---------------------- -------------AGTA-------------AATTTAGTAAAACC--------CCTATGG- -------AAAACA-GTTTGGAG--GTTC-CTCAAAAAACTAAAA--ATAGAACTACCA-- -TATGA--TCCAGCAATCCCACTGCTAGG-TATATACCCCAAAAA-AAA--GAAA----- -------------------ATCAGTAT-ATTGA--AGAGATATCTG----------C--- ---------ACTCT--CATGTTTATTGCAGCACTATT---CACAATA-GCCAAAATTTTG GGA-AGCA--ACCTAAG-TGTCCATCA---ACAGATG-----AATGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTACATAT----ACACAATGGAGTAC--TATTCA-GCC ATAAAA----------------------AAGAATGAGATCCTGTCATTT----------- ------------------------------------------------------------ -GCAACAACATGGATGGAA-C---T----------------GGAGGTCATTATGTTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GGCAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAG---- -----------------------------ACAAACTT-CGCATG--------TTC----- ------TCACT---TAT------------------------TTGTGGG------CTAAAA ATTAAAACA--------------ATTGAA---------------C--------------- ------------------------------------TCATG-------------GAGA-- -------TA------------------------------------------GAGAGT--- -AGAATGATGGT---TACCA-----GAGGCTGG----------GAAGGG----------- TAGTGGGGGGGG------------------------------------------------ --GGG-------GGGGGA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGT-----------------GGGGATG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GTTAATG---------------------------------------------- --------GGTA----CAAAAATA----------------------------TAGTTAGA ATGAAT--------------------------AAGATCTAGTATTTGATAGC-------A CAA-----------------------------------------------------CAGG GTGACTACAGTC------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACAATAATT-- ----------------------TATTGTACA--------TTTTAAAATAA---CTAAA-- -------------AGAGTATAATTGGATTGTTTGTAACAC-----AAAGAAAGGATAAAT GCTT----------------------------------------GAGGTGATGGATACCC CATTT-----ACCCTGATG------------------------------TGATTATTATG C-----ATTG-TATGCC-------------------------------TGTATC------ ------------------------------------------------------------ ----------------------------------------AAAATATCTCAT---GTACC CCATAAATATATACACCTA------------CTATGTA----CCCACAAAA------AT- -------TAAAA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MA1 -----------------------GGGGAGGCGGAGCAAGATG--GCAGAAT-AGAAAGCT CCACCGATTGT----CCCCCCT--------GCAAGGACACCAAGTTAACAACTATCTACA CAGAAAAAAACACCTTC----ATAA---------GAACCAAAAATCAGG--------TGA GC--TCATAGTACCT-----GGTTTTAACTTCATATCGCTGAAA-----------GAGGC ACTG---AAGAAA----TAGAAAAAACAGTCCTGA--------------ATCACCGATGC CACCCCTCCCCCACCCC-----CGGCAGCGGCAGCATGGTGCAGAG-------------- -----------AGCATCTCTG-----------------GGTGCTGGGGGAGGGAGAACAC AGCAATTGT----GAGGCATTGAACTCAGT----GCTGTCCTGTTAG-----AGCAGAAA GGAAAACCAG---------------------------ACCAAAC-TCAGCTGATGCCCGC C-------------------------CACGGAGGGAGCATTTAAACCAGCCCTAGCCAGA GGGGAATCGCCGATCCCAGTGGTC------------------------------------ ---CGAACTTGAGTGCCTGCAAACCTCACCACCGAGGGCTACAGCGCTCTGTGTCTCCAA GTAAACTTGAAAGGCAGTCTA---------GGCCATAAGGACTGCAACTCTTAGG----- ------------------------------------------------------------ --------------------CGAGTCCTAGTGCTGAACTAGGCCCAGAGACAGTGGACTG GGGGGGCACGTGA-------------CATACTGAGACACCAGCTGGGGCAGCCAAGGGAG TGCTGGCATCACCC-CTCCCCTAACCCCAGGCTGCACAGCTCA----------------- ---TGGCTCCAAAAGAGACCCCTTCCTTCCACTTGAGGAGAGGAGAGGG----------- ------------------------------------AAGAGTGGGGAGGAT--------- -------------------TTGTCTTGCATCTTGGATACCAGCTCAGCCACAGCAGGATA GGGCGGTCAGAGTCGTGAGGC-------------------CCCTGTTCCAGCCCTAG--- -----------------------------------------CTCCCAGATGACATTTCTA GACACACCCTGGGCCAGAAGGGAACCCGCTGCCTTGAAGGAAAGGACCCAGTCCTGGCAG CATTCATCACCTGCTAACTGAAGAGCCCTTGGGCC---------CTGAATAACCAGCAGC GA-------------TACCCAGGTACTACATCGAGGGCCTTGGGTGAGCCTCTGAGACTT GCT----GGCTTCAGGTGAGACTCAGCACATTACCAGCTGTGGTGGCTA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TGGGGCAAAACTCCTTCTGCTTGA------------------GAAAAGCA GAGGGAAAAGTAAAGGGGACTTTGTCTTGCACCTTAGGTACCAGCACGGCCACAGGGGGG TAGAGCACCAAGTGGGCTCTTGGGGTCCCTGATTCCAGGACTTGACT----CTTGGATGG CATTTCTGGACCTGCCCTGGGCCAGAGGGGAGCCCA------------------CTGCCC TGAAGGGTGAGTCCCAGGCCAGGCAGCATTCACCACA----------------------- ---------------------------AGCTGACTTAAGAGACCTTGGGCCTTAAGGGAA CATCGGTGGTAGTCTGGCAGTACTCCTCGTGGCCTGGGGTGGCGGT-------------G GCTATGGGG------TGAGGCT--CCTCTGCCTTTGGAAAGGGGAGGGAAGAGTGG---- ---------GAA-----GGACTG--------------CATCTTGTGGTTTGAGTGCCAGC TCA----------------------------------GCTGCAATACAAT---------- ------------AGAACACCAGGTAGACTTCTAAGGT-------------------TTTT GACTCTAGTCC---CTGACTCCCGGATGGC-----ACTTCTGG---------------AC CCACCCGGGG--CCTGGGGGACCTCGCCGCCCTGAAGGGAAGGACACAGGCCTGGCTGGC TTTGCCACCTGCTGATTGTAGAGCCCCAGGGCC----TTGAGCGAACATAGGCAGTAGCC AGGGAGTGGTTACAGCAGGCCTTGGGTGAGACCCAGTGCTGT------------------ ------GCTGGCTTCAGGTCTGACCCAGTGCAGTCATAGTGGTGGTGGCCACAGGGGTGC TTGTGTCACTCCACCCCCAGCTTTAGGTGGCTCAGAACAGAGAGAGAGACTCTGTATGTT TGGGAGAAAGTAAGGGAAGAGAACAAGAGTCTCTGCC------------------TGGTA ATCCAGA-----------------------------------GAATTCTCCCGGATCTTG TCCAAGACC----------ATCAAGGCGGTACCTCTATGAGTCTGCAAGAA--------- CCACAGTGTTACTGGGCTTGGGG------------------------TGCCCC---CTAA AGCAG-------------ATACAGCTTAGATCACAA------------------------ ------------------------------------------------------------ -----CACCCAAGTCCTTTCAAATA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TCTGGAA------------------------------AGC C-----------TTC--------------------------------------------- ------------------------------------------------------------ ----------------------------------CCAAGAAGGATGGCTACA-------- ------------------------------------------------------------ -----------AATAAGCC----------------------CA----------------- ------------------------------------------------------------ --GACAGTGA-AGACTACA----------------------------------------- ---ATAAATACCTAACTCTTC--------------------------------------- -----------------------------------AATGCCCAG---------------- ------ACACCGAA-------GAACATCTACT-------AGCATCAACACCATCCAGGAA AACATGACCTCAC-----CAA------------ATGAACTAAATAAGGCA---------- CCAG---GGACCAATCCTG-------GAG-------AAAC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGA-GATATGTG ACCT------TTCAGACA------GAGAA------------TTCAAAAT---AGCTGT-G TTGAGGA---AACTCAAAGAAAT----TCAAGATAACA---------------------- ---------CAGAGAAGGAATTCAGAATTCTATCAGATAAATTTAACAAAGAGAT----- ----------------------------------------T------------------- -------GAAATAATTAAAAAGAAT---CAAGCAAAATTCTGGAGCTGAAAAATGCAGAA ATTTTATTGTATAAATTTACCGGAGAAACAGAGATATGGTATAACAAAGAGATTGAAATA --------------------------------------ATTTTAAAAAAT---------- -----CAAAGAGAAA--------------------------------------------- ------------------------TTCT-GGAGC---TGAAA---------AATGC---- -AATTGGCATA----CTGAAGAATGCATCAG-------AGTC------------------ --------------------------------------------CTTTAATAGCAGAAT- -----TGATC--AAGC------------------AGAAG---------AAAG-AAT-TAG TGAGCTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACAGGCTATTTGAAA-A--TACACAG------TCAA---------AGAA--- ------------------GACAAAAGAAAAA---AGA---ATAAAAAACAA--------- TGA-AGCATGCCTACAG--GATCTAGAAA-ATAGCCTC-----------AAAAG--GGCA AATCTAAGAG-TTATTGG-----CCTTAAAG--------------AGGAGGTAGAGAAAG AGATAGGGGTAG---------AAAGTTTATTCAA--A--------GGGATAATAAC-A-G AGAACTTCCCAAACCT--------------------AGAGAAAGATATCA--ATATCCAA GTAC-----AAGAAGGTTATAGAAC---ACCAAG-CAGAT--------TTA--------- ---A-CCCAAAGA-----AGACTACCTCAA----------------------------GG CATTTAATAATCAAACT------CCC-AAAGG---------TCAAGGATA---------- ------------AAG--AAAGGATCC---------------------------------- --------TAAAAGCAGCAAGAGA---AAAGAAAC--------------AAATAAC---A TAC----------AATG--------------GAGCTCCAAT--ACATCTGG-C--AGCAG ACT--------TTTCAGTGGAA--ACCTTA-CAGG--CCAG-GAGAGAGTG--------- ----GCA-TGACATA-T-------TTAAAG--T-GCT-GAAGGAAAAA------------ -AAC-TT--TTA--CCCTAGAA--------TAGTAT----------ATCTG--------- --GTGAAAATATCC-----TTCA-AACATGA-------AGG-AGAAATAAAGACTTTCCC AGACAAACAAAAAGCTGAGGGA-TTTCATCAATACCAGAC---CTGTCCTAC-AAGAAAT GCT--------------AAAGGG----------------------AGTACTTCAATCAGA AAGAAC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AAAACTCACTGGTAATAGTAAGTACACAGAAAAACACAGAATATTATAA CACTGTAACTGTGGTGTGTAAACTACTCTTATCC---TAAGTAGAAAGACT--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AAATGATGAACCAATCAAAAA TAATAACTA--------------------------------------------------- ----------------------------------------------CAACAACTTTTCAA GACATAGTACAATAAGATATAAATAGAAACAACAAAAAGTTAAAAAGCAGGGGGACGAAG TTAAGGCATAGAGTT--------------------------------------------- ---------------------------------------TTTATTAGTTTTCTTTTTGCT TGTTTGTTTATGCAAATAGTGTTAAGTTGTTATCAGGTTAAAATA--------------- ----------------------------------ATGG---------------------- GTTATAAGATAGTATTTGCAAGCCTCATGGTAACCTCAAACCAAAAACATACAATGG--- ------------ATACACAAAAAATAAAAAGCAAG-----------AAACTAAATCATAT CACCAG------AGAAAATCACC------T---------------TCAC-------TAGA ----GG-----------AAGACAGGAAGGAA-------AGAAAGAAG-----GAAGAGAA GACCACAAAACAACCAGAAAACAAATAAC---------------------------A--- ------------------------------------------------AATGGCA----- --------------------GGAGTAA--GTCC-TTACTTATCAATAA------------ -------------TAAC-ATTGAATG-TAAATGGACT--AAACTC---TCCAATCAAAAG ACATAGAC--TGGCTGAA-TGGAT------------GAAAAAACAAGACCCATTGA---- ---TCT-GTTGCCTACAAGAA-ACACACTT-CACCT--ATAAAGACACACATAGACTGAA AA--TAAAGGGA--TGGAAAA-AGATATTCCATGCCAATGG------AAACC-------- -------------AAAAA-AGAGCAG--GAGTCACTATACTTATATC-AGACAAAATAGA TTTCAAG-AC----------AAAAACTATAAGAAGAGAC-AAAG-AAGGTCACTATAT-- ----AATGATAAA---GGGGTCAATTCAGC--AAGAGG--------AT-ATAACAATTTT AA-----------------ATATATATGCACCCAACACTGGAGCACCCAG--ATATATAA AGGAAATATTATTAGAGCTAAAGAGAGAGATAGGCCCCAATAC---------AATAATAG CTGGAGACTTCAACACCCCAC-----TTTCAGCATTGGACAGA----------------- ----TCTTCCAGAC------AGAA-----AATCAACAAAGAAACATCAGACTTA------ --ATCTGCACTATAGACCAAATGGAT-CTAATAG--ATATTTACAGAA--CATTTCATCC AAGAGCTG---CAGAATACACATTCTTTTCC-------TCAGCACAT---GGATCATTCT C------AAGGATAGACCATATGTTAGGTCACAAAACAAG-------------------- -TCTTAAAACATTCAAAAAAA--TTGAAAT----------------AATATCAA------ -GCATCTTCTCT---GACCACAATGGAA-TAAAACTAGAAATTAATAACA--------AG A-------------GG-AATTTTG---GAAACTATACAA----ATACATGGAAATTAAAC AATATG-CTCCTGAA---TG-ACCAGTG--GGTCA---ATGAAGAAAT--TAA-GAAGGA AATTGAAAAATTTCTT---GAAAC------------------------AAATGATAATGG -AAACACAAC--ATACCAAAACCTA-TGG-GATACAGCAAAAGCAGTACTAAGAGGGAAG --TTTATAGCTATAAGTGCCTACATCAAAAAAG---AGGA--AAAACTT---CAAATAAA ------CAATCTAATAATGCATCTTAA---AGAACTAGAAAA---GC---AAGAGCAAAC CAAACCCA-AAATTAGTA------------GAAGAAAAGAAATAAT-AAAGATCAGAGCA GAAATA---AATGAAATTGAAATGAAAAAAA-------TACAAAAGATA-AATAAAACAA -AAAGT-------TGTTTTTTTGAAAAGTTAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGACAAACCT---TTAGCCA------GACT-------------- ---AAAAAAAAAAAG---A---GAGA-AGATCCAAATAAA-------------------- -----TAAAA---T---------CAGAAATGAAAAA------GGAGA---CATTACAACT G--------ATAC-TGCAGAAATT-CAAAGGATC--ATTAG---------TGGCT----- -------------------ACTATGAGCAA-CTATATGCCAATAA--AT---TGGAAAAT CTAG---AAGAAAT--GGACAAATTCCT--A---GATACA---------TAC-----AAC CTACCA------AGATTGAACCAGGAAGAAATCCAAAACCTGAAC--------------- --------AGACCA------A------TAACAAGTAATGAGAT----CAAAG--CCATAA -TAAAAAGTCTCCCAGTAAAGAAAAG--CC-CAGGACC--TGATGGCTTCACTGCTGAA- TTCTA------------CCAAACATTT----AAAGAAGAACTAATA-CCAATC-----C- ----TACTCAAACTATTCCAA-------AAAATAG-AGGAGGAGGG-----------AAT ACTTCCAAACTCATTCTATGAG---------GCCAGTAT---TACCCTGATACC--AAAA C-----------------------CAGAC--AAAGACA-CATC----AA---------AA AAAGAAAACT---------------------ACA------GGCCAATAT--CTC----TG ATGAATATTGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACCA------------------AA--T------------ ---T-CA--ACA-------------ATACATT---------AGAAAGATCATTCA--TCA ----TGAC------------CAAGTGGGA-TTTATCCCTGGGA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATGC----AAATCAATCAATGTG--ATA CATCAT---------A------TCAACAG----AATGAAGGATAAAAAC---CATATGA- ----TCATTTC---AATT----------GATGCTGA-AAAAG---CATTTGATAA---AA TTCAACATCCCTT-------------------CATGA---------T-AAAAAC-CCTCA --AAAAACTGGGGATAGAAGGAACAT-----ACCTCAACATAAT---------------- -----------AAAAGCCAT-ATAT-GACAGACCCACAGC-----------TAGTAT--C ATACTGAATGGGGAAAA-A-----CTGAAAGC-CTTT---CCTCTAAGAT----CTGGAA CACGACAAGGATGC-------CCACTGT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTGTTATTCAA-CATA--GTACT---GGAAG TCCTAGCTAG--------AGCAATCAG------ACAAGAG---AAAGA--TATAAAGGGC ATCCAAATTGGAAA-------GGAAGAAGTCAAA--TTATCCTTG-----TTTGCAGATG AT--ATGATCTTA-------TATTTGGAAAAACCT---------------AAAGA---CT CCACAA---------GAA--AACTATTAGAACT---------GATAAA--CAAATTCAGT AAAG--TT-------------------------GCAGGATACAA--------------AA TCAACAT------------ACAAAAAT----CAGTAGCATTTC--TA-TATGCCAA--CA GTGAACAATGTGA------------------AAAAGAAATTTAA-----AAAGTAATCCC ATTTACAATAGC-CACACA---TAAAATTAAATACCTAGGAATTAACTT--------AAC -CAAAGAAGTGAAAGATCTCT---ATAATGAA--AACTATAAAACACTGATG-AAAGAAA TTGAAGA-----------GG------------------ACAC--CAAA--AAATGGAAAA ATAT------T---CCATGTTCATG------GATTGGAAGAATC-----AATA-TTGTT- ------------------------AAAATGTCCA-TA-CTACCC-AA------------- ----AGCAATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------ACCAATG- AC------------ATTCTT---------------------------------------- --CACAGAAATAG---AAA------AAAAAATCCTAAAA-TTTATATGGAA-------CC ACAAAAGACCCA---GA--ATAGCCAAAGCTATCCTAAGCAAAAAGAACA---AAAC--T -------GGAGGAATCACA---TTACCTGACTTCAAATT-----ATACTACAG---AGCT ATAGT-AACCAAAAC-AG------CATGGTACTGG--CA-----------------TAAA AACAGACA------CATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAC AAA---TCCACACACCTACA----GTGAAC--TCATTTTT---GACAAA--GGTGC--CA AGAACATAC--ACTGG-----GGAAAAG----ACAGT--------CTCTT--CAATAAAT GGTGCTG----------G-GAAAAC--TGG-A-TATCCA---------------TATGC- AGA---------AGA--ATGAAACTAGACCCCT----ATCT---------------CTCA CC--ATATACAAAAA-TCAAAT-CAAAATGGATTAAAGACTTAAATCTA--AGACCTCAA ACT-AT------------------------GAAACTACTACAA----------------- ------GAAA--ACATT------G---------GGG---------AAAATCTCCAGGAC- --ATT-----GG-TCTGGGCAAAAATTTCTTGAGCAA-TACCCCA-CAA----GCACAGG CAACCAAAGCAAA----A------AT---GGAC--AAA-TGGGATCAC--AT-------- -------------------------------------------------------C-AAG TTAAAAAGCTT-CTGCA---CAGC-AAAGGATACAATCAAC-AAAG-TGAAGAG-ACAAC CCAC--AGAA--T-GGGAG--AAAATATTT---GCAAACTACCCAT--------CTGACA AGGGATTAA-------TAACCAGAATATATA--AGGAG--CTCAA-----ACAAC----- ----------------------TCTATAGGAA------AAAATC------------T--- AATAATCTGA-TCAAAA----------AATGGGCAAA-----------AGA--TTTGAAT ---AGACATTTCTCAAAAGAAGACATACAAA--------------TGGCAAAC-AGGCAT ATGAAAAGGTG----CTCAACATCATTGA-TCATCAGAGA-AAT--GCAAATC-AAAACT ACAATGAGA---------------------TATCATCTCACCCCAGTTAAAATGGCTT-- ----ATATCCAAA---AGACAGGCA-----------ATAACAA--ATG--CTGGC-A--- ---------------AGGATGTGGAGAA-------------------------------- -----AAGGGAACCCTTGT-ACACTGTTGG--TGGGAA---------------------- -------------TGTA-------------AATTA-GTACAACC--------ACTATGG- -------AGAACA-GTTTGGAG--GTTC-CTCAAAAAACTAAAA--ATTGAGCTACCA-- -TATGA--TCCAGCAATCCCACTGCTGGG-TATATA-CCCAAAAG-AAA--GGAA----- -------------------ATCAGTAT-ATCAA--AGAGATATCTG----------C--- ---------ACTCC--TATGTTTGTTGCAGCACTGTT---TACAATA-GCTAAGATTT-G GA--AGCA--ACCTAAG-TGTCCATCA---ACAGATG-----AATGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTACATAT----ACACAATGGAGTAC--TATTCA-GCC ATAAAA----------------------AAGAATGAGATCCAGTCATTT----------- ------------------------------------------------------------ -GCAACAACATGGATGGAA-C---T----------------GGAGATCATTATGTTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GGCAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAG---- -----------------------------ACAAACAT-CACATG--------TTC----- ------TCACT---TAT------------------------TTGTGGGGAT---CTAAAA ATCAAAACA--------------ATTGAA---------------C--------------- ------------------------------------TCATG-------------GACA-- -------TA------------------------------------------GAGAGT--- -AGAAGGATGGT---TACCA-----GAGGCTGGG---------AAGGGT----------A GTGGGGGGTGGG------------------------------------------------ --GGG-------GAGGTG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GGG---------------------ATG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GTTAATG---------------------------------------------- --------GGTA-------------------------------AAAAAAAAATAGAAAGA ATGAAT--------------------------AAGACCTACTATTTGATAGC-------A CAA-----------------------------------------------------CAGG GTGACTATAGTC------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AATAATAACT-- -------------------TAAT--TGTACA--------TTTTAAAATAAC--TTAAA-- --------------GAGTGTAATTGGATTGTTTGTAACTCAAGGATAAATGCTT------ --------------------------------------------GAGGGGATGGATACCC CATTCTCCATGATGTGCTT------------------------------ATTTCAC---- ------ATTG-CATGCC-------------------------------TGTATC------ ------------------------------------------------------------ ----------------------------------------AAAACATCTCAT----GTAC CCATAAATATATACACCTA------------CTATGTA----CCCACAAAA------AT- -------TAAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MA2 -------------------TGATGGGGGGGGGGGGAGAGAAAAAGAGGGAA-AGAAATCG GGACACATCATT--CTTCCCCC--------GTGAGAAGGACACCAATTTAACAATACTCA CAAAAAAAAAAGCACCTCCATAAGA---------ACCAAAAATCAGGTG--------AGC AC--TCATAGTACCT-----GGTTTTAACTTCATATTACTGAAA-----------GAGGC ACTG---AAGAGG----TAGGAAAAACAGTCCTGA--------------ATCGCTGATGC CACCCCTCCCCCAACCCC----CGGCAGCGGTGGTGTGGTGTGGAG-------------- ------------AGTGTTTCT-----------------GG--GCGCTGGGGGAGGGAGAG CACAGCAATTGTGAGGCATTGAACTCAGTG----CTGTCCTGTTATA-----GC-AGAAA GGAAAACCAG---------------------------ACCAAAC-TCAGCTGATACCCAC C-------------------------CATAGAGGGAGCATTTAAACCAGCCCTAGCCAGA GGGGAATCACTGATCCCAGCGGTC------------------------------------ ---AGAACTTGAGTTCCCACAAGCCTCACCACCACGGGCTAAAGTGCTCTGGGGCTCCAA ATAAACTTGAAAGGCAGTCTA---------GGCCACAAGGACTGCAACTCCTAGGT---- ------------------------------------------------------------ ---------------------GAGTCCTAGTGTTGAACTTGGCCCAGAGACAGTGGACCT GGGGGGGCATGTG------------ACCTACCGAGACACCAGCCAGGGCAGCTAAGGGAG TGCTGGCATCACCT-CTCCCCCAACCCCCGGCTGCACAGCT---CA-------------- ---CAGCTCCAAAAGAGACCCCTTCCTTCCACTTGAGGAGAGGAGAGGGAAGAGTGGGGA GGACTTTGTCTTGCATCTTGGATACCAGCT------CAGCCACAGCAGGATAGGGCACCG GTCAGAGTCATGAGGCCCCCATTCCAGGCCCTAGCTCCCAGACGACATT----------- -TCTAGACACACCCTAGGCCAGAAGGGA------------ACCCGCTGCCTTGAAGG--- ---------------------------------------------GAAGGACCCAGTCCT GGCAGGATTCATCACCTGCTAACTGAAGA--------------GCCCTTGGGCCCTGAAT AACCAGCAGTGATACCCAGGT--ACTACGTCGAGG----------------GCCTTGGGT GA-------------GACTCTGAGACTTG----CTGGCTTCAGGTGAGACTCAGCACATT CCCAGCTGTGGTG---------------GCTATGGAGCAAGACTC--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CTTCCTCCTTGA------------------GAAAAGCA GAGGGAAAAGTAAAGGGGACTTTGTCTTGCACCTTAGGTACCAGCTCGGCCACAGGGGGG TAGAGCACCAAGTGGGCTCTTGGGGTCCCCGATTCCAAGACTTGGCT----CTTGGACGG CATTTCTGGACCTGCCCTGGGCCAGAGGGGAACCCA------------------CTCCCC TGAAGGGTGAGTCCCAGGCCAGGCAGCATTCACCACA----------------------- ---------------------------AGCTGACTGAAGAGCCCTTGGGCCTTAAGGGAA CATCAGCAGTAGTCTGGCAGTACTCCCCGTGGGCCTGTGGTGGTGGT------------G GCCATGGGG------TGAGGCT--CCTCTGCCTTTGGAAAGGGGAGAGAAGAGTGG---- ---------GAA-----GGACTG--------------CGTCTTGTGGTTTGAGTGCCAGC TCA----------------------GCCGCAGTACAAT---------------------- ------------AGAACACCAGGTAGACTTCTAAGGT-------------------TTTT GACTCTAGTCC---CTGGCTCCCAGACGGC-----ACCTCTGG---------------AC CCGCCTGGGG--CCTGGGGGAACTTGCTGCCCTGAAGGGAAGGACACAGGCCTGGCTTGC TTTGCCACCTGCTGATTGTAGAGCCCCAGGGCC----TTGAGTGAACATAGGCGGTAGCC AGGGAGTGGTTACAGCAGGCCTTGGGTGAGACCCAGTGCTGT------------------ ------GCTGGCTTCAGGTCTGACCCAGCGCAGTCCTAGTGGTGGTGGCCACAGGGGTGC TTGTGTCACTCCATCCCCCGCTCGATTTGGCTCGGTCAGAAAAGAGAGACTCCCTTTGTT TGGGAGAAAATAAGGGAAGAGAACAAGAATCTCTGCC------------------TGGTA ATCCAG-----------------A------------------GAATTCTTCCGGATTTTG TCCAAGACC----------ATCAAGGTGGTACCTCTATGAGTCTGCAAGAA--------- CCACAGCGTTACTGGGCTTGGGG------------------------TGCCCC---CTAA AGCAA-------------ATACAGCTTAGATCACAA------------------------ -------------------------------------------CACCCA----------- -----------AGTCCTTTCGAATA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TCTGGAA------------------------------AGC C-----------TTC--------------------------------------------- ------------------------------------------------------------ ----------------------------------CCAAGAAGGATGGGTACA-------- ------------------------------------------------------------ -----------AACAAGCC----------------------CA----------------- ------------------------------------------------------------ --GACTGCGA-AGACTACA----------------------------------------- ---ATAAATACCTAACTCTTC--------------------------------------- -----------------------------------AATGCCCAG---------------- ------ACACAGAT-------GAACATCTACA-------AGCATCAAGACCATCCAGGAA AACATGACCTCAC-----CAA------------ATGAACTAAATAAGGCA---------- CCAG---GGACCAATCCTG-------GAG-------AAAC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGA-GATATGTG ACCT------TTCAGACA------GAGAA------------TTCAAAAA---AGCTGT-T TTGAGAA---AACTCAAAGAAAT----TCAAGATAACA---------------------- ------------------------------CAGAGAAGGAATTC-----AGAATT----- ----------------------------------------C------------------- --TATCAGATAAATTTAACAAAGAG---ATTAAAAA--T--------------------- ----------------------AATAA-------------ATAA------AATAAAGGAG --------------------------------------ATGGAATAGAT----------- -----AAGAAGAATC--------------------------------------------- ------------------------AAGC-AGAGT---TGAAA---------AATGC---- -AATTGACATA----CTGAAGAATGCATCAG-------AGTC------------------ --------------------------------------------TCTTAATAGCAGAAT- -----TGATC--AAGC------------------AGAAG---------AAAG-AAT-TAG TGAGCTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACAGGCTATTTGAAA-A--TACACAG------ACAG---------GAGA--- ------------------AACAAAAGAAAAA---AGA---ATAAAAAACAA--------- TGA-AGCATGCCTACAA--GATCTAGAAA-ATAGCCTC-----------AAAAG--GGCA AATCTAAGAG-TTATTGG-----CCTTAAAG--------------AGGAGGTAGAGAAAG AGATAGGGGTAG---------AAAGTTTATTCAA--A--------GGGATAATAAC-A-G AGAACTTCCCAAACCT--------------------AGAGAAAGATATCA--ATATTCAA GTAC-----AAGAAGGTTATAGAAC---ACCAAG-CAGAT--------TTA--------- ---A-CCCAAAGA-----AGACTACCTCAA----------------------------GG CATTTAATAATCAAACT------CCC-AAAGG---------TCAAGGATA---------- ------------AAG--AAAGGATCC---------------------------------- --------TAAAAGCAGCAAGAGA---AAAGAAAC--------------AAATAAC---A TAC----------AATG--------------GAGCTCCAAT--ACGTCTGG-C--AGCAG ACT--------TTTCAGTGGAA--ACCTTA-CAGG--CCAG-GAGAGAGTG--------- ----GCA-TGACATA-T-------TTAAAG--T-GCT-GAAGGAAAAA------------ -AAC-TT--TTA--CCCTAGAA--------TAGTAT----------ATCCA--------- --GTGAAAATATCC-----TTCA-AACATGA-------AGG-AGAAATAAAGACTTTCCC AGACAAAC-AAAAGCTGAGGGA-TTTCATCAACACCAGAC---CTGTCCTAC-AAGAAAT GCT--------------AAAGGG----------------------AGTTC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TTCAATCTGAAAGAACAAAACTCACTGGTAATAGTA AG---------TACAC----------------AGAAAAACACAGAATATTATAA------ CACTGTAACTGTGGTGTGTAAACTACTCTTATCC---TAAGTAGAAAGACT--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AAATGATGAACCAATCAAAAA TAA--------------------------------------------------------- ------------------------------------TAACTACAACAACTTTTCAAGACA TAGACAGTACAATAAGATATAAATAGAAACAACAAAAAGTTAAAAAGCAGGGGGACAAAG TTAAGGTGTAGAGTT--------------------------------------------- -----------------------------------TTTATTAGTTTTCTTTTTGCTTGTT TGTTTGTTTATGCAATCAGTGTTAAGTTGTTATCAGCTTAAAATA--------------- ----------------------------------ATGG---------------------- GTTATAAGATAGTATTTGCAAGCCTCATGGTAACCTCAAACCAAAAAACATACAATGG-- ------------ATACACAAAAAATAAAAAGCAAG-----------AAACTAAATCATAT CACCAG------AGAAAATCACC------T---------------TCAC-----TAAAAG ----GA------------AGACAGGAAGGAA-------AGAAAGAAG-----GAAGAGAA GACCACAAAACAACCAGAAAACAAATAAC---------------------------A--- ------------------------------------------------AATGGCA----- --------------------GGAGTAA--GTCC-TTACTTATCAATAA------------ -------------TAAC-ATTGAATG-TAAATGGACT--AAACTC---TCCAATCAAAAG ACATAGAG--TGGCTGAA-TGGAT------------GAAAAAACAAGACCCATTGA---- ---TCT-GTTGCCTACAAGAA-ACACACTT-CACCT--ATAAAGACACACATAGACTGAA AA--TAAAGGGA--TGGAAAA-AGATATTCCATGCCAATGG------AAACC-------- -------------AAAAA-AGAGCAG--GAGTAGCTATACTTATATC-AGAAAAAATAAA TTTTAAGAAA----------AAAAATTTTAAAAAGAAAC-AAAA-AAGGTCACTATAT-- ----AATGATAAA---GGGGTCAATTCAGC--AAGAGG--------AT-ATAACAATTTT AA-----------------ATATATATGCACCCAACACTGGAGCACCCAGATATATATAA AACAAATATTATTAGAGCTAAAGAGAGAGATAGACCCCAATAC---------AATAATAG CTGGAGACTTCAACACCCCAC-----TTTCAGCATTGGACAGA----------------- ----TCTTCCAGAC------AGAA-----AATCAACAAAGAAACATTAGACTTA------ --ATCTGCACTATAGACCAAATGGAT-CTAATAG--ATATTTACAGAA--CATTTCATCC AATGGCTG---CAGAATACACATTCTTTTCC-------TCAGCACAT---GGATCATTCT C------AAGGATAGACCATATGTTAGGTCACAAAACAAG-------------------- -TCTTAAAACATTCAAAAAAA--TTGAAAT----------------AATATCAA------ -GCATCTTCTCT---GACCACAATGGAA-TAAAACTAGAAATCAATAACA--------AG A-------------GG-AATTTTG---GAAACTATACAA----ATACATGGAAATTAAAC AATATG-CTCCTGAA---TG-ACCAGTG--GGTCA---ATGAAGAAAT--TAA-GAAGGA AATTGAAAAATTTCTT---GAAAC------------------------AAATGATAATGG -AAACACAAC--ATACCAAAACCTA-TGG-GATACAGCAAAAGCAGTACTAAGAGGGAAA --TTTATAGCTATAAGTGCCTACATCAAAAAAG---AAGA--AAAACTT---CAAATAAA ------CAACCTAATGATGCATCTTAA---AGAACTAGAAAA---GC---AAGAGCAAAC CAAACCCA-AAATTAGTA------------GAAGAAAAGAAATAAT-AAAGATCAGAGCA GAAATA---AATGAAATTGAAATGAAGAAAA-CAA---TACAAAAGATC-AATGAAACAA -AAAGT-------TGGTTTTTTGAAAAGTTAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGACAAACCT---TTAGCCA------GACT-------------- ----AAGAAAAAA-----A---GAGA-AGACCCAAATAAA-------------------- -----TAAAA---T---------CAGAGATGAAAAA------GGAGA---CATTACAACT G--------ATAC-TGCAGAAATT-CAAAGGATC--ATTAG---------TGGCT----- -------------------ACTATGAGCAA-CTATATGCCAATAA--AT---TGGAAAAT CTAG---AAGAAAT--GGACAAATTCCT--A---GACACA---------TAC-----AAC CTACCA------AGATTGAACCATGAAGAAATCCAAAACCTGAAC--------------- --------AGACCA------A------TAACAAGTAATGAGAT----CAAAG--CTGTAA -TAAAAAGTCTCCCAGTAAAGAAAAG--CC-CAGGACC--TAATGGCTTCACTGCTGAA- TTCTA------------CCAAACATTT----AAAGAAGAACTAATA-CCAATC-----C- ----TACTCAAACTATTCCAA-------AAAATAG-AGGAGGAGGG-----------AAT ACTTCCAAACTCATTCTATGAG---------GCCAGTAT---TACCCTGATACC--AAAA C-----------------------CAGAC--AAAGACA-CATC----AA---------AA AAAGAAAACT---------------------ACA------GGCCAATAT--CTC----TG ATGAATATTGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACCA------------------AA--T------------ ---T-CA--ACA-------------ATACATT---------AAAAAGATCATTCA--TCA ----TGAC------------CAAGTGGGA-TTTATCCCTGGGA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATGC----AAATCAATCAATGTG--ATA CATCAT---------A------TCAACAG----AATGAAGGACAAAAAC---CATATGA- ----TCATTTC---AATT----------GATGCTGA-AAAAG---CATTTGATAA---AA TTCAACATCCCTT-------------------CATGA---------T-AAAAAC-CCTCA --AAAAACTGGGGATAGAAGGAACAT-----ACCTCAACATAAT---------------- -----------AAAAGCCAT-ATAT-GACAGACCCACAGC-----------TAGTAT--C ATACTGAATGGGGAAAA-A-----CTGAAAGC-CTTT---CCTCTAAGAT----CTGGAA CACAACAAGGATGC-------CCACTTT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTGTTATTCAA-CATA--GTACT---GGAAG TCCTAGCTAG--------AGCAATCAG------ACAAGAG---AAAGA--AATAAAGGGC ATCCAAATTGGAAA-------GGAAGAAGTCAAA--TTATCCTTG-----TTTGCAGATG AT--ATGATCTTA-------TATTTGGAAAAACCT---------------AAAGA---CT CCACAA---------AAA--AACTATTAGAACT---------GATAAA--CAAATTCAGT AAAG--TT-------------------------GCAGGATACAA--------------AA TCAACAT------------ACAAAAAT----CAGTAGCATTTC--TA-TATGCCAA--CA GTGAACAATCTGA------------------AAAAGAAA-TAAAA----AAAGTAATCCC ATTTACAATAGC-CACAAA---TAAAATTAAATACCTAGGAATTAACTT--------AAC -CAAAGAAGTGAAAGATCTCT---ACAATGAA--AACTATAAAACACTGATG-AAAGAAA TTGAAGA-----------GG------------------ACAC--CAAA--AAATGGAAAA ATAT------T---CCATGTTCATG------GATTGGAAGAATC-----AATA-TTGTT- ------------------------AAAATGTCCA-TA-CTACCC-AA------------- ----AGCAATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------ACCAATG- AC------------ATTCTT---------------------------------------- --CACAGAAATAG---AAA------AAACAATCCTAAAA-TTTATATGGAA-------CC ACAAAAGACCCA---GA--ATAGCCAAAGCTATCCTAAGCAAAAAGAACA---AAAC--T -------GGAGGAATCACA---TTACCTGACTTCAAATT-----ATACTACAG---AGCT ATAGT-AACCAAAAC-AG------CATGGTACTGG--CA-----------------TAAA AACAGACA------CATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAC AAA---TCCACACACCTACA----GTGAAC--TCATTTTT---GACAAA--GGTGC--CA AGAACATAC--ACTGG-----GGAAAAG----ACAGT--------CTCTT--CAATAAAT GGTGCTG----------G-GAAAAC--TGG-A-TATCCA---------------TATGC- AGA---------AGA--ATGAAACTAGACCCCT----ATCT---------------CTCA CC--ATATACAAAAA-TCAAAT-CAAAATGGATTAAAGACTTAAATCTA--AGACCTCAA ACT-AT------------------------GAAACTACTACAA----------------- ------GAAA--ACATT------G---------GGG---------AAACTCTCCAGGAC- --ATT-----GG-TCTGGGCAAAAATTTCTTGAGTAA-TACCCCA-CAA----GCACAGG CAACCAAAGCAAA----A------AT---GGAC--AAA-TGGGATCAC--AT-------- -------------------------------------------------------C-AAG TTAAAAAGCTT-CTGCA---CAGC-AAAGGAAACAATCAAC-AAAG-TGAAGAG-ACAAC CCAC--AGAA--T-GGGAG--AAAATATTT---GCAAACTACCCAT--------CTGACA AGGGATTAA-------TAACCAGAATATATA--AGGAG--CTCAA-----ACAAC----- ----------------------TCTATAGGAA------AAAATC------------T--- AATAATCTAA-TTAAAA----------AATGGGCAAA-----------AGA--TTTGAAT ---AGACATTTCTCAAAAGAAGACATACAAA--------------TGGCAAAC-AGGCAT ATGAAAAGGTG----CTCAACATCATTGA-TCATCAGAGA-AAT--GCAAATC-AAAACT ACAATGAGA---------------------TATCATCTCACCCCAGTTAAAATGGCTT-- ----TTATCCAAA---AGACAGGCA-----------ATAACAA--ATG--CTGGC-G--- ---------------AGGATGTGGAGAA-------------------------------- -----AAGGGAACCCTTGT-ACACTGTTGG--TGGGAA---------------------- -------------TGTA-------------AATTA-GTACAACC--------ACTATGG- -------AGAACA-GTTTGGAG--GTTC-CTCAAAAAACTAAAA--ATAGAGCTACCA-- -TATGA--TCCAGCAATCCCACTGCTGGG-TATATA-CCCAAAAG-AAA--GGAA----- -------------------ATCAGTAT-ATAAA--AGAGATATCTG----------C--- ---------ACTCC--CATGTTTGTTGCAGCACTGTT---CACAATA-GCCAAGATTT-G GA--AGCA--ACCTAAG-TGTCCATCA---ACAGATG-----AATGGATAAA--GAAAA- TG---------------------------------------------------------- --------------------TGGTACATAT----ACACAATGGAGTAC--TATTCA-GCC ATAAAA----------------------AAGAATGAGATCCTGTCATTT----------- ------------------------------------------------------------ -GCAACAACATGGATGGAA-C---T----------------GGAGGTCATTATGTTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GGCAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AGAAAG---- -----------------------------ACAAACAT-CACATG--------TTC----- ------TCACT---TAT------------------------TTGTGGGGAT---CTAAAA ATCAAAACA--------------ATTGAA---------------C--------------- ------------------------------------TCATG-------------GAGA-- -------TA------------------------------------------GAGAGT--- -AGAAGGATGGT---TACCA-----GAGGCTGGG---------AAGGGT---------AG TGGGGGGGTGGG------------------------------------------------ --GGG-------GGAGGT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GGG--------------------GATG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GTTAATG---------------------------------------------- --------GGTA----CAAAAAAA----------------------AATAGTTAGAAAGA ATGAAT--------------------------AAGACCTAGTATTTGATAGC-------A CAA-----------------------------------------------------CAGG GTGACTATAGTC------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AATAATAATT-- -------------------TAAT--TGTACA--------TTTTAAAATAA---CTAAA-- -------------AGAGTATAATTGGATTGTTTGTAACAC---------AAAGGATAAAT GCTT----------------------------------------GAGGGGATGGATACCC CATTT-----TCCATGATG----------------------------------TGATTAT TATGC-ATTG-CATGCC-------------------------------TGTATC------ ------------------------------------------------------------ ----------------------------------------AAAACATCTCAT---GTACC CCATAAATATATACACCTA------------CTATGTA----CCCACAAAA------AT- -------TAAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MB5 -----------------------------CCGTTCCAAGATG--GCCGAAT-AGGAACAG CTCCGGTCTGC---AATTCCCA--------GCATGATCGAGA------------------ ---------------------CAGA----------AGACAGGTGATTTC--------TGC AT--TTCCAACTG-A-----GGTAACTGGTTCATCTCATTGGGA-----------CTGGT CGGA---AAGTGGGT--GCAG----------------------------CCCACGGAGGG C---------------------GAGCCAAAGCAGGATGGGGCATCG-------------- ------------CCTCACCTG-----------------GG--AAGT--GCAAGGGGTGG- -------------GGGG---ATTTCCCTTT----CCTAG-----CCA-----AT-GGAAG CTGTGACAGACTGTAC------CGGGAAAATCGGGAGACTATGATTCTAAACACTGCGCT T-------------------------TTCCAATGG-TCTTAGCAAATGGT----ACACCA GGAGAT-TATATCCCACA---CCT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGCTCAGTGG----- -----GTCCCATGC-CCACAGAGC------------------------------------ -------------------CTTGCTCACTGC----------------------------- ------------------------------------TAGTCCAAGAT------------- -------------------GGAACTGCAA-GGTGGCA------------------AGCCT GCCTGGGGG------AGGGGC-------------------GTCTGCCATTGTTGAGG--- -------------------------------------------TTTGAGTAG-------- -----------GTAAACAAAGCAGCCTGG--------------AAGCTTGAACTGA---- -------------------GTGGAGCCCACCGCAG----------------CTCAACGA- -----------------------------------GGAC--------------------- -------CACCTG---------------CCTCTGTAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ACTCCACCTCTGGGG-----------------------GCA GG-GCATAGCT-------------------------------GAACAAA----------- ---------------------------------------AGGCAGCA------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GAAAC-------------------- TTCT--------GCAGAC------------------------------------------ -TTAAATGT------CCCTGTC--TGACAGCTCTGAAGAGA------------------- -----------------GCAGTG--------------GT----------------TCTCC CAG----------------------CATGGTGTTTGAGGTCTGAAAAGGG--------AC AGACTTATAAATCAACTGTCTCAAATATGCTTAAATAGT-----------------AAAA GATTAAAAGAC-----------------------------------------------AT TGGAAAAAAA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AAAAAAAAAAACTAAA--------------------------------- ------------------------------------------------------------ --TAAAACT----------AAAAGCACAATTAATAAAAAAATAGGAAATCA--------- --------------------------------------------------------ATAA AAAGA-------------TAGCAATATAAAAAGTAA------------------------ ----------------------------------------------TCAAAAATAAAT-- --------TCTTGATATGAAAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GAAAAAA------------------------------AAT T-----------AAAATTCAAAATTTACTA------------------------------ ------------------------------------------------------------ -------AAAAAGAACAAAAGAAAATTTAAGCAAACAAAATAAAAAAACAAAAAATAAGA A----------------------------------------------------------- -----------AAAAAAAC----------------------------------------- -------------AAATAAAATT------------------------------------- --AACATAAATAAAAAAGA------------AAAATAAATTAAAAAAAAATAAATAATAT ATAATAAATAAATAGAAAATC--------------------------------------- -------------------CCAAAAGGGGCGAAGAAATGAGTAA---------------- ------AGGCAGAA-------ACAGAAGGGTA-------GGAGAGAATAAAAAAAAGAGG AAGAACGTCTTTT-----TAA------------ATAATGGCACCAAACCT---------- CC-----CAAAATTAAAGA-------AAG-AAATGAAGCTACTTATTCCGA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGA--ATTAATG AACTTTAAGTAAAAAAAA-----------------------CTCGAAAA----------- -----AA---ATCCCTCTGAGAT----AATAGTAAATG---------------------- ------------------------------TTGAAAGCCATAAT---AAAAAA------- ------------------------------------------------------------ -------GAAAATCTTGAAAGCAGCAGAATAAAAGGAAGTCGG----------------- ----------------------CACAAACATGGGGAGAAACCAG------AGCAGAAAAG ------------------------------CTGAAAATTCTAAAAAACAGAGCGCCCCTT CTTCTCCAAAGGATCGCAGTAAGAGACCAGCAACACACCAAAGCAGGAGTGAAACAT--- ------------------------TTCA-AAAGC---CGAAA---------TATAC---- -AAGTGATAAA----ATGAAAAAAAATATTG-------AAAC------------------ --------------------------------------------CCTCAACACAAAAAT- -----AGATC--AGGC------------------AGAAG---------AAAG-AAT-TAG TGTGCTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGATAGGATAATTGAAA-T--TACAGAG------GCAG---------AGGA--- ------------------GATAAAAGAAAAA---AAA---ATAAAAAAAAA--------- TGA-ACAAAACCTAAAA--GAAATGTGGG-ACAATGTC-----------AAAAT--GGCA AATCTAAGAT-TAATTGG--CCTTCAAGAAG--------------AGGACAGAGAGAGAG GAATAATGGTAG---------AAAATTTATTCAA-TA--------AACATAATAAT---G AAAACTTTCCAAAATT--------------------GATAAAAGACATTA--ATCTACAC ATCC-----AAGAAGCTCAAAAAAC---GCCAAGCAGAAT--------AAA--------- -----CTCAAAGA-----GAACTACACCAA----------------------------GA CACATAATAATCAAATT------GCC-AAAGG---------AGAAAGAGA---------- ------------AAG--AGAGAATCC---------------------------------- --------TGAAAGCAGCAAGAGA---GAAGATAC--------------CTTTGATTCAT TAT----------GAAG--------------GGGCCATCAT--AAATCTAA-C--AACAG ATT--------TTTCATCAGAA--ACCATA-AAGG--CAAG-GAGACAGTG--------- ----GGA-TGAAATA-T-------TTAAAG--A-GCT-GAAAGAAAAA------------ -AAA-TT--TCA--ACAAAAAA--------TTCTAT----------ATTCA--------- --GCAAAACTATTC-----TTCA-AAAATGA-------AGA-AGAAATTAAGGCATTCCC AGATAAAC-AAAAGCTGAGAGA-GTTTATTGCTAGTAGAC---CTGCCCTAC-AAGAGCT CCT--------------GAAGGAAG--------------------AGTCCTTAAACATGG AAAGGAACAACCGGTACCAGCCACTGCAAAAACTAAGCAAAGAATTGAACAAAAAAATTG TCAACCGAAAATCATAAATTGAAAATAAAATTCTTCAAAACGAAGGAGAAATTAAGACAT CCCTCGATAAACAAAAGATAAGTGAGTGCATTCCTTGCTGGTACACCTGCCCTATAAGAA ATGCTAACAGGAGTCCTTCAAGCTGAAATGAAAGGACACTAGACAGTAACTCAAAGCTAC ATGAAGAAAT-AAAGAACACTAGCAAAGGTAACTACCTAGGTAAATATAAAATACAGTAT TATTATATTTTTGATTTGTAATACCTCCTTTTCTCTATTAGATTTAAAAGA--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CAAATGCATAAAA-------- ------------------------------------------------------------ ---------------------------------CAATCATTATAAATCTATTTTGACGGG CACACAATGAATAAAGATGTAATTTGTGACAACAACAACATAAGGGGACGAAAGGAGCTT TTTAAGGAGAAAAGT--------------------------------------------- ------------------------------------------------------------ ---TTTTATATATAATTGAGATTAAGTTGATATTAATTCAAACTAG-------------- ----------------------------------ATTG----------------TTTTAA ATTTAACTATGTTAATTGTAATCCGCAGGATAACCACT---------------------- ----------------------------AAGAAAAGAAATAAAAATAAATCAATAAAAAG GAAAACAAAGAATAAAAAATGGT----------------------ATTC-----TACAAA ----AAAACTATCTAAAAACAAAAGGGAGGAATTGTAGAAGAATTG------AGGAACAA AAAAAAATGACATATAGCACACAAATAAC---------------------------A--- ------------------------------------------------AATGACA----- --------------------GGAGTAA--GTCC-TTTCTTATCAATAA------------ -------------TTAC-ATTAAATG-TAAATGGATT--AAACTC---TCCAATTAAAAG ACAAAAAT--TGGCAAAA-TGGAT------------TAAAAAACAAGATCCATCTA---- ---TAT-GCTGTCTACAAGAG-ATTCACTT-TAGAT--CCAAAGACACAAATAGGTTGAA AG--TAAAAGGA--TGGAAAA-AGATATTCCATATAAAAATTA----AAAAC-------- -------------AAAAGAGAGGTAG--GAGTGGCTATACTAATATC-AGACAAAATAGA CTTTAAG-TC----------AAAAATTATTACAAGAGAC-AAAG-AAGGACATTATAT-- ----AATGATAAA---AGGGTCAATTCATC--AAGAAA--------AT-ATAACAATTAT AA-----------------ACATATATGCACCCAACAACAGAGCCCCAAA--ATATATAA AGCAAAAATTGACAGAATTGAAGGGAGAAATAGACAGTTCTAC---------AATAATAG TTGGAGACTTCAATACCCCAC-----TTTCAATAATGGATAGA----------------- ----ACAACTAGAC------AGAA-----GATCAATAAGGAAATAGAGGACTTG------ --AACAACACTATAAACCAAATAGAT-CTAACAG--ACATATATAGAA--CACTCCACCC AACAACAG---CAGAATATACATTCTTCTCA-------AGTGCACAT---GGAACATTCT C------CAGAATAGACCATATGTTAGGCCACAAAACAAG-------------------- -TCTTAATAAATTTAAAAAAA--TTGAAAT----------------CATACAAA------ -GTATATTCTCT---GACCACAATGGAA-TGAAACTAGAAATCAATAACA--------GA A-------------GA-AAAACTG---GAAAATTCACAA----ATATGTGGAAATTAAAC AACATA-CTCTTAAA---TA-ACCAGTG--GGTCA---AAAAAGAAAT--CAA-AAGGGA AATTAGAAAATACTTT---GAGAT------------------------AAATGAAAATAA -AAACACAAC--ATACCAAAACTTA-TGG-GATGCAGTAAAAGCAGTGCTCAGAGGGAAA --TTTATAGCTGTAAATACCTACATTAAAAAAG---AAGA--AAGATCT---CAAATCAA ------TAACCTAACTTTACACCTTAA---GGAACTAGAAAA---AG---AAAAACAAAA TAAACCCA-AAGCTAGCA------------GAAGGAATAAAATAAT-AAAGATTAGAGCA GAAATA---AATAAAATAGAATATAAAAAAA-CAA---TAGAAAAAATT-AAT------- ----------------TTTTTTAAAAAGATCAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGACAAACTT---TTAGCTA------GACT-------------- GACAAAGAAAAAAAA---AAGAGAAA-AGACTCAAATTAC-------------------- -----TAAAA---T---------CAGAAATAAAAAT------GGGGA---CATTACTACT A--------ACCT-TACAGAAATA-AAAAGGATT--ATAAG---------AGAAT----- -------------------ACTATGAACAA-TTGTATGCCAACAA--AT---TAGATAAC CTAG---ATGAAAT--AGACAAATTCCT--A---AAAACA---------CAC-----AAA CTACCA------AAACTGACTCAAGAAGAAATAGAAAATCTGAAT--------------- --------AGACCT------A------TAACAAGTAAAGAGAT----TGAAT--CAGTAA -TAAAAAAATTTCCCACAAAAAAAAA--CC-CAGGACC--AGATAGCTTCACTGGTGAA- TTCTA------------CCAAACATTT----AAAAAAAAAATAAAAATCATTT-----T- ----TCTTCAAATTTTTC-AA-------AAAATAG-AAAAGGAAGG-----------AAT ACTTCCTAACTCATTCTATGAG---------GCCAGCAT---TACCCTGATACC--AAAG C-----------------------CAGAC--AAAGATA-TCAC----AA---------GA AAAAAATACA------------------------------GACCAATAT--CCC----TT ATGAATATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACCT------------------AGAAT------------ ---CCCA--GAA-------------GAAAATA---------AAAAGAATTATACA--CCA ----TAAC------------CAAGTGAGG-TTTATTCCAGGAA-AGCAAG---------- -------------GGTTGTTTAAATTCAAAAAAAAA----AAATTAATCAATGTA--ATA CACCAC---------A------TTAATAG----AATAAAGGAAAAAACC---CATATAA- ----TTATCTC---AATT----------GATGCAGA-AAAAG---TATTTAACAA---AA TCCAACAACCTTT-------------------CATGA---------T-TAAAAC-ACTCA --ACAAACTAGGAATAGAAGAGAACT-----TTCTCAACATGAT---------------- -----------AAAGGGCAT-TTAT-GAAAAACCCACAGC-----------TAACAT--C ATACTCAATGGTAAAAG-A-----CTGAAAGC-TTTT---CCCCTAAGAT----CAGGAA CAAGACAAGGATGC-------CCACTTT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTTCTATTCAA-CATT--GTATT---GGAAG TTCTAGCCAG--------AGCAATTAG------GCAAGAA---AAAAA--AATAAAAGGC ATCCAAATTGGAAA-------GGAAGAAGTAAAA--CTATCTCTA-----TTTGCAGATG AC--ATGATCTTA-------TATATAGAAAAAACT---------------AAAGA---AA CAACAA---------AAA--AACTAATAAAACT---------AATAAA--CAAATTCAGC AAAG--TT-------------------------GCAGGATACAA--------------GA TCAACAT------------ACAAAAAT----CAGTTGTATTTTTATA-TACACCTA--AA AAAAAAAATCTAA------------------AAAATAAAATTAAA----AAAACAATTCC ATTTATAATAGC-ATTAAA---AAGAATAAAATACTTAGGAATAAATTT--------AAC -CAAGGAGGTGAAAGACTTGT---ACACTGAA--AACTACAAAACATTGCTG-AAAGAAA TTAAAGA-----------AG------------------ACCT--AAAT--AAATGGAAAA ACAT------C---CCATATTCATG------GATTGGAAGACTT-----AATA-TTGTT- ------------------------AAGATGACAA-TA-CTCCCC-AA------------- ----AGTGATCTACAGA---TTCAATGCAATCTCTATCAAAAT---------CCCAATG- AC------------CTTTTT---------------------------------------- --TGCAGAAATGG---AAA------AGCTGACTCTAAAA-TTCATATGGAA-------TT TCAAGGGACCCA---AA--ATAGCCAAAACAATTTTAAAAAAGAAGAACA---AAGT--T -------GAAGAACTCATA---CTTCCTCATTTCAAAAC-----TTACTACAA---AACT ACAGT-AATCAAAAC-AA------TGTGGTTCTAG--CA-----------------TAAG GATAGACA------TATAGAT--CAATGGAATAGAATTGAGAGTCC------AG--AAAT AAA---CCCATACATCTATG----GTCAAT--TGATTTTA---AACAGG--GTTC---CA AGAACATTC--AATGG-----GGAAAGA----ATAGT--------CTCTT--TAACAAAT GGTGCTG----------G-GGAAAC-ATGG-A-TATCCA---------------CATGC- AAA---------AAA--ATGAAATTGGACCCCT----TCCT---------------CACC CC--ATATACAAAAA-TTAATT-CAAAATGGATCAAAGACCTAAATATA--AGAGCTAAA ACT-AT------------------------AAAACTCTTAGAA----------------- ------GAAA--ACATA------G---------GGA---------TAAATCTTCATGAC- --CTT-----GG-ATTTGGCAATGGTTTCTTAGATAT-AACACCA-AAA----ACAATAG CCAAAAAAGAAAA----A------AT---AGAT--AAA-TTGGACTTA--AT-------- -------------------------------------------------------AAAAA TTAAAAA-TTT-TTGTA---TAAA-AAAAAAAATTATCAAG-AAAG-TGAAAAG-ACAAC TTAC--AGAA--G-GGGAA--AAAATATTT---GCAAATTATATAT--------CTGATA AGGGTCTAG-------TATCCAGAATATATA--AAAAACTCTTAA-----AAAA------ ----------------------TCAAAAAAAA------AAAAA----------------- AAAAACCCCAATTATAA----------AATGGGCAAA-----------ATA--TTTGAAT ---AGATATTTTTTCAAAGAAGATATACAAA--------------TGGCCAAG-AAGCAC ATGAAAAGATG----CTCAACATCATTAA-TCATTAGGGA-AAT--GAAAATC-AAAACC ACAATGAGA---------------------TACCACTTCACACCCAATAGGATGGCTATA ATTTTTATTAAAAAAAATAAGGAAAAAGGGTAAATAACAAGGGTTAGGATGTGGA-GAAA GAAGCTAGTATGGATAGGAGGTGGAGAA-------------------------------- -----ATTGGAACTCTATT-ACATTGGCGGGTGAGGAA---------------------- -------------TGTA-------------AAATG-GTACAGCC--------ATTGTGG- -------AAAACA-GTTTGGCA--GTTC-CTCAAAAAGTTAAAC--ATAGAATTACTA-- -TATGA--CCCAGCAATTCCACTTCTAGG-TATATA-CCCAAAAGAAAT--AAAAACATG TTTACACAGATACTTGTGCACCAGTAT-GTTTA--ACAAAACCTTG----------T--- ---------ACATG--AATGTTCATAGCAGCATTATT---CACAATA-GCCAAAAGGC-A GAGAAACA--ACCCAAA-TGCCCATCA---ACAAATG-----AATGGATAAA--TAAAA- TG---------------------------------------------------------- --------------------TGGTATATAC----ATACAATGGAATAT--TATTCA-GCC ATAAAA----------------------AGGAATAAAGTACTGATACAT----------- ------------------------------------------------------------ -GTTACAACGTGGATGAAC-C---T----------------TGAAAACATTATGCTAAAT GA-------------------------------------------------------AAG A----------------------------------------------------------- ----------AGCCA---GAAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------CAAAAG---- -----------------------------GCCAATAT-TGTATG--------ATT----- ------CCATT---CAA----------------------------TGAAATATCCAGAAT A----------------------GGCAAA---------------T--------------- ------------------------------------CCATA-------------GAGA-- -------CA------------------------------------------GAAAGC--- -AGATTGGTGGT---TGCCA-----GGGGCTGGG---------GGGAGG----------- ----GGGGAATG------------------------------------------------ --GGG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AGTGACTG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CTTAATG---------------------------------------------- --------GGTA----CGGGGTTT------------------------TCTTTTGGGGTG ATGAAA--------------ATGTTTTGGAATTAGATAGAGGTGGTGGTTGC-------A CAA-----------------------------------------------------CATT GTGAATGTACTA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AATGCCACTG-- ----------------------AATTGTACA----------------------CTTTA-- ------------------------------------------------------------ ------------------------------------------------------------ AAATG------------------------------------------------------- ------GTTAAT------------------------------------TTTATG------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TTATATGAATTTCACCTCAA------TT- -------AAAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MB1 ---------------------------GAGTTCCGCAAGCTG--GCAGAGT-GGGAAGCC CTAGATTCTCCTTCCCTTCACAAACACACCGATTGAGCAACAATTCATGGACAAATTCCC TTTTTAAGAAATTCAG-----AAAC---------TAATTGAAAGGCTCC--------TGC AC--CCTTGATG--------AGTGTGAAACCAGACTCATCAAAG-----------CTGAT AGGGAAATTCAAGACACCCT-----------------------------CTCACCAGAAT C----------------------------------------------------------- -----------TCTACCCCTG---------------------------GCACAGTTCCAT ACAATA-------GGGACGAGACCCCTCAT----CCCTCAGCTTCTC-----TGAGGAGA AGGAAAGGGGTATTA----------------------ACTAGGT-TCAACGCTCTACCTT T-------------------------TTCTGGGGGTACCCAGAGGACTGG---------- -------GCTCTCCCTAG---CCT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GCGTTGGG------ -----GTCCTACGC------GGAC------------------------------------ ------------------------------------------------------------ ------------------------------------TGGTCTAAGCCTG----------- -------------------CAGGCTAAAGGGGAAGAG----------GGATTGTGGTTTG GAACTGGTGGACCCCATAGAC-------------------CCCCCCCCTGGCTCGGC--- ------------------------------------------------------------ -----------ATAAATCAGAGGGATGAA--------------AAACCCCAGCTCT---- ----------------------TAGCTTCTCCCTGGGGAGGAAAAGAGTTGGACAACGGA TC---------------------------------------------------------- --------CAATG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ACCCAACTTTTCGGG-------------------------- ---GGACATCC-------------------------------GAAGAAATTG-------- --------------------------------------CATTCAGCTC------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------CTCTATC--CTGGAACTCTGGTGGGGTCGGTACAGGCCT------ ---------GGACAGGTGAGGAGGACAGAAGCATTGGCTTTGAATACTCTAACTTACCCA CAT----------------------CTCACAACTCGACATCTAGGAAAG----------- ------------------------------------------------------------ ---------CCAGGGTAACCCCA-----GCGTCCGGCGGCTCT---------------AT GGGTAGGAAA-----------------------AAAGGT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TTGGGAGGACTCCAGAA-------------------------------- ------------------------------------------TCTCTAGCCAGGCTGATT GGTGAAGGTCTTTTTCTGTACAAGGCCAGTCTGTGAAGTCTGGGAAGAGTG--------- -----------------------------------------------TTTTTTTTCTTTT GCAGA----------------AAGTGGACGACACAA------------------------ ------------------------------------------------AGTGCCAAAGAA AATGAAAAATCAGGCAAAGATGTTC----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------CAAATAA------------------------------AGG A-----------ACAAAATAAATCTC---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CAGAAACC----------------------------------------- ------------------------------------------------------------ --AACCCTAACGAAATAGA--------------G-------------------------- ---ATATATAATTTACCTGAC--------------------------------AGAGAAT TCAAAATAACTGTCATAAAGTGTTTCATGGGGGCAAATGAGGAG---------------- ------AAACCAGA-------ACACAAACGCT-------GAAAATTCGAAAAACCAGAGC GCTTCTTCTCCTC-----CAA------------AAGATCACACTTGCTCG---------- CCAG---CAATGGATCCAA-------ACT-GGACGCAAGA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGA-AATCGCTG AATT------GCCAGAAA------AAGAC------------TTCAGAAG---GTTAGT-T ATTAAGC---TATTCACGGAGCT----ACCAGAGAAAG---------------------- ------------------------------GTGAAACCCAACGC---AAGGAAAT----- ----------------------------------------T------------------- -------AAAAAACTTAAAATAAAGGTTATGGATGAAAT--------------------- ----------------------ATTCA-------------CTAG------AATAAAAAGT --------------------------------------TTAGAGAAAAAC---------- -----CAAAAAGAAC--------------------------------------------- ------------------------TTTT-GGAGC---TGAAA---------AGCAC---- -ACTAATAAAA----ATACAAAATTCACTCA-------AAGG------------------ --------------------------------------------ATTCAAAAGCAGATT- -----TGATC--AGGCACAGACTAGATTAAATAGAGAAA---------AAAG-AAT-CAG AAAACTG----------------------------------------------------- ------------------------------------------------------------ ----AAAGACAAAGTATTTGAAA-T--TATCCAG------TCAG---------AGGA--- ------------------GCAAAAAGAAAAA---AAA---ATGAAAAATAA--------- AGA-AGAAAGCCTAAGG--GACTTATGGG-AGTTCATA-----------AAACA--CACT AAAATATACA-CAATAGG--AGTCCAAGAGA--------------GCCAGAGAAAGAAAG GAAAAAAGGTAG---------AAAACTTATTTAA--A--------GAAATAATGGC-T-A AAAACTTCCCAAATCT--------------------GGGGAAAAAAAAAG--AAATCCAA ATTC-----AAGAAACCCAAAGAAA---CCCAAAAAAAAT--------GAA--------- -----CTCAAAGA-----AATCCACACCAA----------------------------GA CACATTATAATCAAATT------GTC-AAAAG---------TCAAAGACA---------- ------------AAG--AGAGAATTT---------------------------------- --------TGAAAGCAGCAAGAGA---AAAGCATC--------------ATGTTAC---A TAC----------AAGG--------------GGAAATCCAT--AAGAATAA-C--AGAAG ATT--------TCTCAGCAGAA--ATCTTG-CAAG--CCAG-AAGGAAGTG--------- ----GGA-TGATATA-T-------TCAAAG--T-GCT-GAAAGAAAAA------------ -AAA-TT--CCA--ACCAAAAA-------AAATTAT-----------TCAA--------- --GCAAAACTGTCA-----TTCA-AAAATAA-------AAG-AGAAATAAAGACTTTCCC AGACAAAC-AAAAGCTAAGGGA-GTTCATCACCACTAGAC---CTGCCTTAC-AAGAAAT GCT--------------AAAGGG----------------------AGTTC---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------TTCAAGTTGAAAATAAAAGGATGCTAAACAGCAACACAATAGCATAAGAA AGTAT------------------------------------------------------- -----------GAAGCTCATTGGTAAAGGTAAATATATAGACAAATACAGAATACTGTAT TACTGTAATAGTGGTGTGTAAATCACTTTTAATT---CTGGTATAAAATTT--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AAAAGAAAAAATATTTTAAAT AAA--------------------------------------------------------- ------------------------------------TATAAATAAAAATATGTTAAAAGA TACACAATATAAATAGATGTAAATTGTGACAATAATATCATAAAGTATATGTGTGGGGGG GGGAAGGGTAAATGT--------------------------------------------- --------------------------------------------------------GTAG AGTTTTTGTATGTGATTGAAGTTAAGTTGTTATCAGCTTAAA------------------ ----------------------------------ATAG-------------ACTGTTATA ACTATAAGATATTTTATGTAAGCCCCATGGTAACCACAAAAAAAATACCTATAGAAG--- ------------TTACACAAAAGAAAAAAAAAAAA-----------AAATAAAAGCATAG CATTACAAAA--AAAAAAACAAT----------------------AAAA-----CACAAA ----GG------AAGACAGCAAAAGAGGAAA-------AGAGA---------GCCAAAAA AACTATAAGACAGACAGAAAACAATTAAC---------------------------A--- ------------------------------------------------AATGACA----- --------------------AGAACAA--ATTC-ATCCCTATCAATAA------------ -------------TTAC-TTTAAATA-TAAATGGACT--AAACTC---CCCAATCAAAAG ACATAGAG--TGGCTGAA-TGGAT-----------AAAAAAACAAAGACCCAACTA---- ---TAT-ACTCTCTATAAGAA-ACTCACTT-TAGAT--TTAAGGACACACATAGGCTGAA AG--TGAAGGAA--TGGAAAA-AGATATTCCATGCAAATGG------TAACC-------- -------------AAAAG-AGAGCAG--GGGTGGCTATATTTATATC-AGACAAAATAGA CTTTAAG-TC----------AAAAACTGTCACAAGAGAC-AAAG-AAGGACATTATAT-- ----AATGATAAA---AGGGTCAATTCACC--AGGAAG--------AT-ATAACAATTAT AA-----------------ATATATATGCACCCAACATCAGAGCACCTAA--ATATATAA AGCAAACATTGACAGAACTGAAGGGAGAAATAGACAGCAATAC---------AATAATAG TAGGAGATTTCAATACTCCAC-----TTTCAATAATAGACAGA----------------- ----ACATCCAGAC------AGAA-----GATCAATAAGGAAACAGAGGACTTG------ --AACAACACTATAGACCAAATGGAC-CTAACAG--ACATATACAGAA--CATTCCACCC AACAGCAG---CAGAATACACATTCTTCTCA-------AGTGCACAT---AGAACTTTCT C------CAGGATAGATCACATGTTAGGTCACAAAACAAG-------------------- -TCTTAACAAATTTAAAAAAA--TTGAAAT----------------CATACCAA------ -GTATCTTTTCT---AACCACAATGGAA-TGAAACTAGAAATCAATAGCA--------GA A-------------GG-AAAACTG---GAAAATTCACAA----ATATAAAGAAATTAAAC AACATA-CTCTTGAA---CA-ACCATTG--GGTAA---AAAAAGAAAT--CAA-AAAGGA AATTAGAAAATATCTT---AAAAC------------------------AAATGAAAACAA -AAACACAAC--ATACCAAAACTTA-TGG-GATGCAGCAAAAGCAGTACTAAGAGGGAAG --TTTATAGTGATAAATGCCTACATTAAAAAAG---AAAA--AATATCT---CAAATAAA ------C---CTAACTTTATACCTCAA---GGAACTAGAAAA---AA---AAAAACAAAC TAAGCCCA-AAGTTAGCA------------GAAGGAAGGAAATAAC-AAAGATTAGAGCA GAAATA---AATAAAATAGAAAATAGAAAAA-CAAATAGAAAAAAAACA-AATAAACTAA -AAATT-------TGTTTTTTTAAAAAAATAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGACAAACTT---TTAGCTA------GACT-------------- AACTAAAAAAAAAAA---A---GAAA-AACAAAAAATAAA-------------------- -----TAAAA---T---------AAGAAATGAAAGA------GGAGA---CATTACAACT G--------ATGC-CACAGAAATA-AAAAAGATC--ATAAG---------AGACT----- -------------------ATTATGAACAA-TTATATACCAACAA--AT---TGGATAAC CTAG---AAGAAAT--GAATAAATTCCT--A---GAAACA---------TAC-----AAC CTACCA------AAACTAAATCATGAAGAAATAGAAAATCTGAAC--------------- --------AGACCT------A------TAACTAGTAAGGAGAT----TGAAT--CAGTAA -TCAAAAACCTCCCAACAAAGAAAAG--CC-CAGGACC--AGATGGCTTCACTGGTGAA- TTCTA------------CCAAACATTT----AAAGAAAAATTAATA-CCAATT-----C- ----TTCTCAAACTCTTCCAA-------AAAATTG-AAGAGGAGAG-----------AAC ACTTCCAAACTCATTTTATGAG---------GCCAGCAT---TACCCTGATACC--AAAG C-----------------------CAGAA--AAAGACA-CCAC----AA---------GA AAAGAAAACT---------------------ACA------GGCCAATAT--CCC----TG ATGAATATAGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAAC--------------------AAATT------------ -----TA--ACA-------------ACACATT---------AAAAAGATTATACA--CCA ----TGAC------------CAAGTGGGA-TTTATTCCTTGGA-TGCAAG---------- -------------GATGGGTC-AAC-----ATTAAA----AAATCAATTAATGTG--ATA TACCAC---------A------TTAACAG----AATAAAGGATAAAAAT---CACATGA- ----TTATCTC---AATA----------GATGCAGA-AAAAG---CATTTGACAA---AA TTCAACATCCTTT-------------------CATGA---------T-AAAAAC-TCTCA --ACAAACTAGGAATAGAAGGAAATT-----ACCTCAACATAAT---------------- -----------AAAGGCCAT-ATAT-GAAAAGCCCACAGC-----------TAACAT--C ATACTCAATGGTGAAAA-A-----CTGAAAGC-TTTT---CCTCTAAAAT----CAGGAA CAAGGCAAGGATGC-------CCACTTT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTTCTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATTAG------GCAAGAA---AAAGA--AATAAAAGGC ATCCAAATCAGAAA-------GGAAGAAGTAAAA--TTTTCTCTG-----TTTGCAGATG AC--ATGATCTTA-------TATATAGAAAACCCT---------------AAAGA---CT CCATAA---------AAA--AACTGTTAAAACT---------AATAAA--TAAATTCAGT AAAG--TT-------------------------GCAGGATACAA--------------AA TCAACAT------------ACAAAAAT----TAGTTTTGTTTT--TA-TATACTAA--AA AAAAACAATATGA------------------AAAAAAAA-TAAAA----AAAAAAATCCC ATTTACAATAAC-AACAAA---AAGAATAAAATACTTAGGAA---ACTT--------AAC -TAAGGAGGTGAAAGACTTGT---ATATTGAA--AACTATAAAACATTGATG-AAAGAAA TTAAAGA-----------AG------------------ACAC--AAAT--AAATGGAAAA ACAT----------CCTTTTTCATT-----GAATTGGAAGACTT-----AATA-TTGTT- ------------------------AAAATGTCCA-TA-CTACCC-AA------------- ----AGTAATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------CCCAATG- GC------------ATTTTT---------------------------------------- --TACAGAAATAG---AAA------AAAAAATTCTAAAA-TTTATATGGAA-------AA CAAAAAGAACCC---TA--AAAACCAAAACAATCTTGAGAAAGAAGAACA---AAGC--T -------GGAGGCATCACA---CTTCCTGATTTCAAAAT-----ATATTACAA---AGCT ACAGT-AATCAAAAC-AG------TATGGTACTGG--CA-----------------TAAA GACAGACA------TATAGAC--CAATGGAACAGAATAGAGAACCC------AG--AAAT AAA---TCCACACATATATG----GTCAAC--TGATCTTT---GACAAG--GGTGC--CA AGAATACAC--AATGG-----GGAAAGG----ATAGT--------CTCTT--CAACAAAT GGTGTTG----------G-GAAAAC--TGG-A-TATCCA---------------CATGC- AAA---------AGA--ATGAAATTGGACCTTT----ATCT---------------TACA CC--ATACACAAAAA-TCAACT-CAAAATGGATTAAAGACTTAAATATA--AGACCTGAA ACT-GT------------------------AAAACTCCTAGAA----------------- ------GAAA--ACATA------G---------AGG---------AAAAGCTTCATGAC- --ATT-----GG-TCTTGGCAATGATTTCTTGGATAT-GACACCA-AAA----GCACAGG CAACAAAAGCAAA----A------AT---AAAC--AAA-TGGGACTAA--AT-------- -------------------------------------------------------T-AAA CTAAAAAGCTT-TTTCA---CAAC-AAAGGAAACAATTAAC-AGAG-TAAAAAG-GCAAC CTAT--GGAA--T-GGGAG--AAAATATTT---GCAAACCATATAT--------CTGATA AGGGGTTAA-------TATCCAAAATATATA--AGGAA--CTCCT-----ACAAC----- ----------------------TCAATAGCAA------AAAAAC------------A--- AAAAACCTAA-TTAAAA-----------AAGGGCAAA-----------GGA--CTTGAAT ---AGACATTTCTCCAAAGAAGACATACAAA--------------TGGCCAAC-AGGTAT ATGAAAAG-------ATCAACATCACTAA-TCATCAGGGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TATCACCTCACACCTGTTAGGATGGCTA-- ----TTATCAAAAAAAAAAAAAAAA------ATAAAATAACAA--GTG--TTGGT-A--- ---------------AGGATGTGGAGCC-------------------------------- --------------CTTGT-TTACTGTTGG--TGGGAA---------------------- -------------TGAA-------------AAATG-GTGCAGCC--------GCTATGG- -------AAAACA-ATTTCGAG--GTTTCCTCAAAAAATTAAAA--ATAGAACTACCA-- -TATGA--TCCAGCAATCCCACTTCTGGG-TATTTA-TCCAAAAGAATT--TAAA----- -------------------ATCAGAAT-CTCAAAGAGAGATATTAG----------C--- ---------ACTCC--TATGTTTATTGCAACACTATT---CACAATA-GCCAAGATGT-G GA--AACA--ACCTAAA-TGTCCATTA---ATAGATG-----AATGGATAAA--AAAAA- TG---------------------------------------------------------- --------------------TGGTATATAC----ATACAATAGAATAT--TATTCA-GCC TTAAAA----------------------AAGAAGGAAATTCTGTCATAT----------- ------------------------------------------------------------ -GCTACAACATGGATGAAC-C---T----------------TGAGGACATTATGCTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GTCAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAAG---- -----------------------------AAAAATACTTGCATG--------ATT----- ------CCACT---TAT------------------------ATAT---------CTAAAA T-------A--------------GTCAAA---------------C--------------- ------------------------------------TCATA-------------GAAG-- -------CA------------------------------------------GAGAGT--- -AGAATGGTGGT---TGCCA-----GGGGCT------------GGGGGG----------- AGGGGGGAAATG------------------------------------------------ --GGG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AGTTGCTG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------TTCAATG---------------------------------------------- --------GGTA----TAGAGTTT------------------------CAGTTATGCAAG ATGAAT--------------------------AAGTTCTAGAGATCTGCTGT-------A CAA-----------------------------------------------------CATT GTGCCTATAGTT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACAATACTG-- ----------------------TATTGTACA--------C-------------TTAAA-- ------------------------------------------------------------ ------------------------------------------------------------ ----------AATTTGTTA----------------------------------------- -----------AGAGGG-------------------------------TAGATC------ ------------------------------------------------------------ ------------------------------------------------------------ --------------TCATG------------TTAAGTGTTCTTACCACAAT------AA- -------A---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MB4 -----------------------TAGTGACATCAGCAAAATG--GCAGACTAGGAAGCTG CA------------ATTTCTCA-------------------------------------- -----------------------------------AGACTTGGGAGCAC--------TAA AT--TTCCCAT---------AGTTCCCCTAAGAAACCATCAGAA-----------ACTAC CAGAACCAACTTTGTAAGAACTCTGGGAAACAATCAACGGATTACACAATTCAGGAAAAG C-------------------TGTAATCAAAATTGGGGGGGATTCCA--TAGCATTTTTGG TCGTTGTGGCGTTGCTGCCTGCTCTTTTAGTATATGATGCTCAGTGTGGCAATAATTTTA GTCAT--------GAGCAGCACAACACAAT----CTTGATTTCTCTA-----ATTGATAA GGGAGTGCAGAATAGT------CTCTATTAGCGAATAATTGTGT-AGGTATGTTCTAACC T-------------------------GTCTGGGGGCTACCTGAAGGACTG----ATGTAA AGTGAGCATCTCTTTTTG---CCT------------------------------------ ----------------------------------------------------AACTCAAT GAGGAAAAGCAGCAGGCATTG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----CTCTCAAAAGCTACAAGA------------------------------------- ------------------------------------------------------------ ------------------------------------TAACATAAGAA------------- -------------------CTGTAGGTGGGTGGGGCCAGAAGATAAAAG----------- ---TGGAGACATACAATAGGC---------------------CATCTAATGCCCAAA--- ---------------------------------------------GGAGAAACTGGAATG AAACTCTTTTGGAAATTAAGACATTCAAAAGTAGT--------CAATTAAAATAGGAAAT TAAAAAAGCAACAACAGAGCCAAAACAAAACATAT---------------ACACAAAAAA GA---------------------------------------------------------- ----------------------------CCTAAGAAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ACCTTAAACTTTCACCTTGG-----------------------GCT GATCCCTAGAC------------------------------------------------- -----------------------------------------TCAGTGCAA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GCCTGGC--TAACTGTTTAAGGAGGGGCATACAT----------- ---------GCAGACCTACAGAG------------------------------------C CAG------------------------------------TCCGTAAAGAGAGAGAGAGGT GGTTTTT-----ATTTTCCATGCTTTATTATTGG----------------------TTTT GTTTTAAGTCC---TGGGATTCC------------------------------------- ------------------------------------------------------------ -------------------------------------CGGAAATCTCTGTCAGAACATTA GCTGAATATAAGCTATAA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AAAAAAGAATTTCATGTCCCA---------------------------- ------------------------------------------------------------ -------------------ACATGAGCAAAAAATAGGTTTTTTAAAAAATA--------- --------------GTTTGGAAA------------------------AGTCACTAAACAA ACAGA-------------CTACT---------ACAG------------------------ ----------------------------------------------CCTTCAAT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AATAAAA------------------------------AAT A-----------AACATACAGA-------------------------------------- ------------------------------------------------------------ --------------------------------CATGCATGCATGCATACATAC------- ------------------------------------------------------------ -----------ATAAA-------------------------------------------- ------------------------------------------------------------ --AACTTTGAAAAAGAGGA----------------------------------------- ---AAATATGATTTCCAGAAT--------------------------------------- ------------------------TACAATATAATAATACTTAA---------------- ------ATGATTAAGTTCAAAAAAAAATCACA-------AGGCATACAAAGAA-CAGGAA AGTATGGCTCATT-----CAA------------AGGAACAAAATAAATTA---------- ACAG---AAACCATTCCTG-------A-------GGAAGC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CCA-GATATTGG AATT------ACTAGACA------AAGAC------------TTTAAATC---AACTGT-C TTAAATA---TGCTTAAAGAGTT----AAAGGAAAACA---------------------- --------------------------------CGGAC----------AAAGAACT----- ----------------------------------------A------------------- -------AAGAAAATCAGAAAAATA---ATATATGAA----------------------- ----------------------CAAAA-------------TGAG------AATATCAAGG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -AATAAGAGAA----ATTTGTAAAA-------------GGAA------------------ --------------------------------------------CCAAACAAACAGATT- -----TGAGC--AGGC------------------AGAAA---------AAAT-GAT-TAG CAAATTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACAAGGCAATTAAAA-T--TATCAAA-------------------ATAA--- ---------------------TAGGGATACA-----A---AGAAAGAAAAA--------- TGA-ACAGTGCCTAAGGAAGATTTGTAAG-ACAACATT-----------AAATACTGATC AATATATGCA-TAATGGG--AATTTCAGAAA-----------------AAGAAGTGAGAG AGAGCATGGCAG---------AAAGAATATTTGC--A--------GAAATAGTGGC-C-A AAAGCTTCCCAAGTTG--------------------GATGAAAGACATGA--ATCTACAA ATCC-----AAGAAGCACAACAAAC---TACAAGTATGTT--------AAT--------- -----CTCAAAGA-----CACCAACAGGGA----------------------------GA AAAATTATAATCAACT-------GTC-AAAAG----------CAAAAACC---------- ------------AAGACAAAGAGCCT---------------------------------- --------TGAAAGCAGCGAGAGA---AGAGAGAC--------------TAGTCAC---A TAA----------AAAA--------------AATTCTCAAT--AAGATTAC-C--AGCCA ATT--------TCTCATCAGAA--ATATTG-TGAG-TCCAG-AAGTCAGTG--------- ----GCA-TAGCATATT-------TTAAAG--A-GCT-GAAAGAAAGA------------ -AAAAACAGTCA--ACCAAGAA--------TTCTAT----------ATCTG--------- --GCAAAACTACCC-----TTCA-AAAATGA-------GGT-AGAAATTAAGACATTTCC AGATAAAC-AAAAGCCAAGGGA-GTTCATTACCACTAGAC---CTGCCTTGC-AAGAAAT GAT--------------AAAGAATGAAAG----------------AACAC---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TAGACAGTAACTTGAAGCCATATGAA GAAATAAAGATCTCTGG------------------------------------------- -----------TAAAG------------GTAACTACATAGGCAAATATAAAAGCTAGTAT TATTGTACTTTTGGTTTGTAACTCCACTTTTATTTTCTTTCTATATTATTT--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AAAAGATAAATGAATAAAA-- ------------------------------------------------------------ ---------------------------------CTATAATTATAAATCTATGTTATTGGG CACACAATGTATAAAGATGTAATTTGTGACAATAATAAAAACAACATAAGGGGAGGGACG GAGATATATAGGAGC--------------------------------------------- ----------------------------------------------------------AG AGTTTTTGTATGCTATTGAAGTTAAGTTGGTATTATTTAAAA------------------ ----------------------------------CTAG-------------GTTGTTATA AGTTTAAGATGTTAATTGTAATCCCCATGGTAACCACTAAAAAATCTGTAAAAT------ ------------ATATATAAAAGGAAATAAAAAGG-----------GAATCAAAATGTTT CACTAA------AAAAAATCAAC----------------------TAAA-----CACAAA ----AG------AAGGCAGTAAT-----GGA-------AGAAATGAGG----GACAAAAA AGCTATAAGACATACAGAAAACA------------------------------------- ------------------------------------------------AATAGCT----- --------------------AAA------AGTCATTCCCTACCAGTAA------------ -------------TTAC-TTTAAATG-TAAATGGATT--AAACTC----CAAATCAAAAG AAATAGAT--TGGCAGAA-AGGAT---------TTTTAAAAAACAGGATACAACTA---- ---TAC-GCTGTCTACAAGAG-ACTCACTT-TAGAT--CTAAAGACACAAATAGGTTGAA AG--TGAAAGGA--CGGAAAA-AGATATTCAATGCAAATAG------TAACC-------- -------------AAAAG-AGAGATG--GAGTGGCTATACTAATATC-AGACAAAATAGA TTTTAGT-TA----------AAAAACTATTATAAAAGAC----A-AAGGACATTACAG-- ----ATTGATAAA---AGGGTCAATTCACC--AAGAAG--------ATAAGAACAATTAT AAAT---------------ATATACACGCACCAAACATCAAAGCTCCAAA--ATATATGA AGCAAACACTGACAGAATTGAATGAAGAAAGAGACAGTTCTAC---------AATAACAG ATGGAGACTTCAACACTCCAC-----TTTCAATAATGGATAGA----------------- ----ACAGCCAGACAGCTAAAGAA-----GAGCAATAAGGAAACAAAGGACTTG------ --AACAACACTATAAACCAACTAGAA-CTAACAG--ACATATATAGAA--CACTCCACCC AACAA------CAGAATACACATTTTTCTTA-------AGTACATAT---GGAACATTCT C------CAGGACAGACCATATGTTAGGCCACAAAACAAG-------------------- -TCTCAATACATTTAAAAAA---CTGAAAT----------------CATACAAACTTTCT TTTATCTTCTCC---AATCACAATGGAA-TAAAACTAGAAATCAATAACA--------GA A-------------GG-AAAACTG---GAAAATTCACAA----ATATGTGGAAATTAAAC AAAACA-CTCTTAAA---CA-ACCATTG--GGTCA---AAGAAGAAAT--CAC-AAGGGA AATTAGAAAATACTTTAAGGAAAC------------------------AAATGAAAACGA -AAACAAAAA--GTACCAAAACTTA-TGG-GATGCAGAAAAAGCAGTGCTAAGAGGGAAA --TTTATAGCTGTAAACGTCAATACAATAAAA----AAGACTAAGATCT---CAAA---- ---------CCCAATTTTACACATTAA---GGAACTAGAAAAAGTATTAAGACAGCAAAC TAAACCCA-AAGTTAGCA------------GAAGGAAGGAAATAAT-AAAGATTAAAGCA GAAATAGAGAACAGAATAAGAACAGAGAAAA------ATACAATGAATA-AACCAGATGA CAAAGT-------TGATTCTTTAAAAAAATCAA--------------------------- -----------------------------------------------------------C AGGAGGTAA------TTGGCAAACTT---TTGGCTA-------CCT-------------- AAAAAAATATACA---------GAGA-AAACTCAAAAAAT-------------------- -----AAAAAGGCCATCTCTACTAGAGAACTACAAA------AACGACTTTCTTAAAAC- --------------GAAAGAAATAGCAAGAGGACAAATAAA---------AGAGT----- -------------------ACTATAAACGA-CTGTATGCCAACAA--AT---TGGATTAT CTAG---ATGAAAT--GGATAAATTCCT--A---GAAACA---------CAC-----AAC CTACCA------AGACTGAATTATGAAGAAACAGAAGATCTGAAT--------------- --------AGACCT------A------TAACTAGTAA-GGATT----TGAATTCTAGTAA -TCAAAAACCTCCCAACAAAGTAAAG--CC-CAGGCC---AGACGGCTTCACAGGAGAA- TTCTATATGAATTCTTCTCAAACATTT----AAAGAAGAATTAACA-CCAATC-----T- ----TTCTCAAACTCTTCCAA-------AAAACTG-AAGAGGAGAG-----------GAA CACTTCCAACTCATTCTATGAGATGAGGCCAGCCAGCATTGATACCCTGATACC--AAAG C-----------------------CAGAC--AAAGGCA-CTAC----CC---------TA CAAGAAAACT---------------------ATA------GAGCAATAT--CCC----TT ATGAATATTGAT------------------------GCAAAAATCC-TCAACTCACATAT GCCATGCAAAATACTAGC-AAACCA------------------AAGTT------------ ---T-CG--GCA-------------GCGTAGCAAATAGCAGAAAAGGATTATACA--AGA ----TGACCATACATCATGACAAGTGGAA-TTTATTCCTGGAA-TGCAA----------- -------------GATGGTTCAAAC-----ATATGA----AAATCAATTAATGTA-CGTA CGCCAT---------A------TGAACAG----AATAAAGGAGAAAA-----AAAATGA- ----TCATCTC---AACT----------GATGCAGA--AAAG---CATCTGACAA---AA TTCAACACCCTTT-------------------CATGA---------T-TAAAAA-TCTAA ----AAA---AGAATGGAAGGAAACTTAAACTCACCAACATAAT---------------- -----------AAAGGCCAT-ATAT-GAAAAACCCACAAC-----------TAACAT--C ATACTCAATGGTGAAAATGAAAGACTGAAAGC-TCACTTTCCCCTAAGAAAATCAAGGAA CAAG-CAAATATGC-------CCGCTTT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTTCTATTCAA-CACA--GTATT---GGAAG CTCTAGCCAG--------AGCAATCAAG-----GCAAGAA---AAATA--AATAAAAGGC ATCCAAATTGGAAA-------GGAAGAAGTGAAAATTCATCTCTG-----TTAGAAGATG AC--ATGATTGTA-------TATGTAGAGAACCCT---------------AGAGA---TT CCAC-----------AAA--AAGTGTTAGAGCT-----------AAAA--TTAACTCAGC AAAA--AT-------------------------CAACACAACAA--------------AA TCAACAT------------GCAAAAAT----CAGCTGCGTTTC--TA-CACACTAA--CA ATGAACAATCTGA------------------AAAGGAAAATTAAG----AAAACAATTCC ATTTACAATGGC-ATCAAA---AAGAATAAAATACTTAGAAATAAACTT--------AAC -CAACAAGGCGATAAAAGTCTTGTACACTGAA--AACTACAAAACATCACTG-AAAAATA TTAAGGA-----------AG------------------ACAT--AAAT--AAATGGAAAG ACAT------C---CCATGTTCATG------GATTGGAAGACTT-----AATA-TTGTTA AGCTGGAAGGAAGACTTAATTTAAAAGATGACAA-TA-CTACCCGAATACAATACTACCC AAAGAGCTATCTACGGA---TTCAATGCAATCCCTATCAAAAT---------CCCAATT- GG------------CGTTTT---------------------------------------- --TTCAGAAGCG----AAA------AGCCCATCCTAAAA-TTCATGTGGAA-------TC TCAAAGGACCCCTAGAA--ATAGCCAAAACAATCTTAAAAAAGCAGAAGAACAAAGT--T -------GGAGGACTCACA---CTTCCCAATTTCAAACC-----TTACTACAAA--AGCT ACAAT-AACCAAAAA-AG------TATGG-ACTAG--AA-----------------CAAT GACAGACA------TATAGAC--CAATGGAACAGAATTGACAGTCC------AG--AAAT AAA---CCCATACATTTATG----GTCAAC--TGATTTTT---TATATG--AGTGC--CA ATACCATTC--AATGG-----GGAAAGAG---AAGTT--------TTTTT--CAACAAAT GGTGCTG----------A-GACAAC--TGG-A-TATCCA---------------CCTTA- AAA---------AAG--AAGAAGTTGGATAC-T----ATCT---------------CATA CCATATTTACAAAAAGTTAACATAAAAATGGATCAGAGACCTAAATTTA--AGAGTGAAA ----AT------------------------AAAATTCTTAGAATTAAAGAACAAAACGTA AGAACTAAAA--ATGTA------GGCTACGAAAAAA---------ACAATCTTCATGAC- --CTT-----GG-GTTTGGCAATGGTTCCTTAAATAT--ATACCA-AAA----GCACAGG CAACAAAAGAAAAC---A------ATAAAAGAT--ACA-TTGGGCTTT--AT-------- -------------------------------------------------------AAAAA TTAAAAA-CTT-TTGTG---CTTC-AAAGGACACCATCAAG-GACA-TGAAATG-ACAAC CCAC--AGAA--T-GGGAG--AAAATATTT---ACAAATCATATAT--------CTGGTA AGGGTTTAA-------TATCCAGAATATATA--AAGAA--CTACT-----ACAAC----- ----------------------TCAACAACAA------AAA------------------- ACAAACACCAATTCAAA---------------GCAAA-----------AGA--CTTGGCC ---------------ATAGAAGATATACAAA--------------TGGCCAA--AAGCAC ATGAAAAGATG----CTCAACATCACTAG-CCACTGGGGA-AAT--GCAAATC-AAAATC ACAATGAGA---------------------TACCACTTCACACTCG-------AGCTA-- ----------AAA-----------------------ATAAAAA--GTG--TTGGTAG--- ---------------AGGATGTGGAGAA-------------------------------- -----ATTGTAACCCTTGT-ACATTGCTGG--TGGGAA---------------------- -------------TATA-------------AAATG-GTGCAGCT--------GCTGTGG- -------AAAACA-GTATGGCA--GTTC-CTCAAAAAATTAAAC--ATAGAATTACCA-- -TATTA--TCCAGGAATTCCACTCCTAGG-TATATA-CTCAAAAG-AAC--TGAT----- -------------------AGCAGAGA-CTCAA--ACAGGTATTTG----------T--- ---------ACACC--AACATTCATAGCAGCATTATT---CACAACA-GCCAGAAGGT-G GC--AACA--ATCCAAA-TGTCCATCA---ACAGATGTTCCAAATGGATATA--AAACA- ------------------------------------------------------------ --------------------TGGTATATAC----ATACAATGGAATAT--TATTCA-GCC TTAAAA----------------------AGGAATGAAATTCTTATACCT----------- ------------------------------------------------------------ -GCTAGAACATGAATGAAC-C---T----------------TGAAAACATTATGCTAAGT AG-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GACAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAGG---- -----------------------------ACGAATAT-TGTATG--------ATT----- ------CCACT---TAT------------------------ACAAGATACC---CAGAAT A----------------------GGCAAA---------------T--------------- ------------------------------------TCATA-------------GAGA-- -------CA------------------------------------------AAAAAT--- -AGAATAGAGGT---TACCA-----GGGGCTGGC---------GGGAGA----------- AGGAATGGGGAGTTACTGTTTAATGGGTACAGAGTTTCTGTTTGGGATGATGAAAAAGTT TTGGAAATGGATAGTGGT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GATGGTTGCACAACATTGTAGAATATA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CTTAATGCCACTGAACTGTACACTTAAAAAGGGTTTGGTAAAAATTTTATGTT ATGTACATTTTA----CCACAATTTTGAAAAAAATATTAGAAGAAAATTTTCCTAATTTG ATAAATGACATCTACATAAAAAAACCTACAGCAAACATCATACTTAATGGTA-------A AAA-----------------------------------------------------TATT GAAAGCTTTCTCCTCGATACCAGAATCGAAATAAGGATGCCTATTATCACCACTTCCATT CAATATTATGCTGGAAGTCCTTGCCATTGCAATAAAAGCAAGAAAAAAGATATAAGTATT GGAAAGGAAGATATAAAACTGTTATTATTTATAGAAAACATGATCGTGTATGTTAAAAAA TTAAAAAATTCAATAGATAAACTATCAGAATTAATAAGTAAATTT---AACAAAGGTT-- -------------------GTATAATATATAGAAAAAATCAATTATACTT---CTATA-- --------------------------------TGACAAATAAATAATTAGAAATGAAAAA ATTAAATATCACTTACAATAGTATCAAAAAACATAAAACACATAGAAATAAATCTAATTT TAAAAGTGTAAGACTGCTA------------------------------CACAGACGACT AAAAGCATTCTTGAACGAAATTTATTAAGACCTAGATAAATGGAGGAGTATATCTTGTTC ATGGATTGGAAAACTCAATATTGTAAAGATGTCAATTTTCCTCAAATTGACCTACATATT TTTGATGCAGTCTCAATCAAAATCTCAGCAGGGTTTTTGTGGAATTTCAAAAGCCGATTC TAAAATTTATATGGAAATG------------CAAAAAGCCAAAAATAAAAC------AA- -------GAGTCTTGAAGAAGAACAAAACTAGAAGGATTTACACTACCAGATATCAAGAC TACATATATAAAGCTATAGTAATTAAGCTATAAAGCTTGTATTGGTACAAGGACAGTCAA ATACCAATAGAATTGCATATACATATATGTACACCAAAAGACACACACACAAATGTTCAT AACAGCCTCTTTCGTAATAAGCCAAAAATGGAAGCAACCCAATCGTCCATCAACAGTAGA ATGGGTAAATTGTGGTATATTCACACCATGGAATACTATGCAGTAATGAAAATGAGATAC CTAGAATAGGCAAATTCATAGAGACAGAAAGTAGATTAGAGGTTACCAGAGGCAGGGGGG AGGGGGGAATGGGAAGTTATTGTTTAATGGGTACAGAGTTTCTGTTGGGGGTAATAAAAT GTTCTGGAAATAGATAGTGGTGATGGTTGTACAACACTGTGAATGTACTTAATGCCACTG AATTGTACACTTAAAAATGGTTAAAATGGCAAATTTTATTTTACGTATGTTTTCCCTCAA TAAA >L1MB2 ------------------------AGTAACCTCAGCAAGATG--GTGAACT---AAGAAG CTCCAGGCTCT---CATTTTCT--------CACAGGGATACC------------------ ---------------------AAGT---------TAACAAATAAATACA--------GAG AA--TAACAACTTTA------------CAAAAACTCTAAAGAGA-----------CCAGT TAAG---AAATTGTTAAACCCAGTTCAATATATAA---------------CCAAGAAGAG A---------------TTATAGTAAAAGAAGTAGGATAATGTGT---------------- ------------------------------------------AGATTTTCGTATAACCA- ----------------------CCCCTTCC----CTACCTCATGGCA-----CACAAAAA TATTGAGATA--------------------------------CT-ACAGCAACCTTCCAT T-------------------------TTCTAGCAGGGGACAGGGAA--------GGGAAA AAAAATCTTGTTCCCCTAATTTCC------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------CTT GTCAGGGGCT------------------------------------CCCCAAAGGACTGG TTTCTGTCTCGCCTGGCTCAGAGCACTGAT------------------------------ ------------------------------------------------------------ ------------------------------------GGGACTGTGGG------------- -------------------TCATTTTGAAAATCGATA----------------------- -GCTCAGGG-------------------------------GCTTGTGGCGGCAGCAG--- ------------------------------------------------ATAGGCCATATA ACTACACAGGCATATACAAGGAAAAAAGA--------------GAGTTAAAA-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------ACTCTTGCCCATGAA------------------------AA GGCACAAA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ACCTATT--TGATAGGAATATAAACCCAAAGCCCAG--------- -----------------GCAGAT--------------CCTCTACCGATATAAGATACCTC CTG--------------------------CATCTCCAGCTAGGCTGATTGATGAAAGTCT TCCCCTGTAAAAAGCCAGT--------CTTTAAAG------------------------- ----------------------------------------------------------AC TGGGAGAGGTGGTTTTTTT----------------------------------------- -------------------------------------TAACTGTCCAATTTTAACAAAAA GAATTACAAC-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------GAAAAAGAAAAAAAAGG-------------------------------- ------------------------------------------------------------ -------------------AAGAAACAGACCATTAAAAAAGCAAAAAAAAA--------- ------------GCAACAGAAAC------------------------TGACCC---TAAA GAAAA---------------------------GCAG------------------------ ---------------------------------------------ATCTAAGACCTACTA GACAAAGACTTTAAAATAACTGTCT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TAAAGAT------------------------------GCT C-----------AATGAGCTAA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AGGAAAAC----------------------------------------- ------------------------------------------------------------ --ACAAACAATAAACAGAA----------------------------------------- ---TCAGAAAAATGATGCATG--------------------------------------- --------------------------------AACAAAATGGGA---------------- ------ATATCAAT-------AAAGATATAAA-------AATAAAAAAAAAATAAAAAGA AATTTTGGAGCTG--------------------AAAAATACAATAACTAAAATGAAAAAT TCAC---TAGAGGGATTCA-------ATA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GCAGACTTGATC A---------GGCAGAAG------AAAAA------------ACTTGAAGACAGTTCATTT AAAATAA--------TATCAGGCCGGAGAAACAGAAAG---------------------- -----------------------------------------------AAAAAAAA----- ----------------------------------------T------------------- ------GAAGAAAAGTGAAGAAAGC---CTAAGGGACTTGTGGGACACCATCAA------ ----------------------GCAGA-------------CCAA------TATATGCATT ATGGGAGTTTCAGAAGGAAGAG----------------AGAGAGAAGAGG---------- -----GCAAAA------------------------------------------------- ------------------------TAAT-AAAGC---TTAAA---------AATAC---- -AGTAAGTAAA----GTGAATAATTCACTAA-------AAAT------------------ --------------------------------------------GTTCAATAGCAGACT- -----AGATC--AGGC------------------AGAAG---------AAAAAAATGAAC AGAACTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGACAGATCATC---------AAGTCAG------AGGA---------ACAA--- ------------------CAACAACAAAAAA----GA---ATGAAAAAAG---------- TGA-AGACAGCCTAAGG--GATTTGTAAG-ACAACATT-----------AAAGT--GATC AATATATGCA-TAATGGG--AATTTCAGAAA-----------------AAGAAGTGAGAG AGAGCATAGCAG---------AAAGCATATTTGA--A--------GAAATAATGGC-C-G AAAACTTCCCAAAATT--------------------GATGAAAGAAATGG--ATATACAA ATCC-----AAGAAGCTCAACAAAC---TCCAACTATGAT--------AAA--------- -----TTCAAAGA-----CACCCACACGAA----------------------------GA TATATTATAATCAAACT------TTC-AAA-----------ACAAAAACC---------- ------------AAG--AGAAAGCCT---------------------------------- --------TGAAAGCA-------A---AGCAAGAC--------------ATACTAAACAC AAA----------AAAA--------------AAAATTTCAT--TAAGTTTA-CAAAGCAG ATT--------TCTAGACAGAA--ACTTTG-GAGG--CCAG-AAGGAAGTG--------- ----GGA---TGATA-T-------TTAAAG--A-ACTAGAAAAAAAAA------------ -AAAAACACCCA--ACCAAT----------TATTGT----------ATCTG--------- --GAAAAACTATAC-----TTCACAAAATGA-------GGG-AGAAATTAGGACTTTCCC AGATAAAC-AAAAGCTGAGGGA-GTTCATTATCATTAGAC---CTGCCTTGCAAAGAAAC ACA--------------AAAGGA----------------------AAATT---------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------AAACAATAAAAGAATGCTAGACAGTAACATGAAAGCATATGAA GATATAAATATCTCTGT------------------------------------------- -----------TAAAG-------GTAAAATATAAACATTTACAAAAACTAGTATCTTTAA TTTTGTAATGTTGGTGCATAAATCAATTTTAATT---CTGGTATAGTATTT--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AAAAGAAAAACATATAAAAA- ------------------------------------------------------------ ------------------------------------TAACTATAAATCTATATTAATGGA TACACAATATAAAAAGATGTAATTTGTTACAATAATATAAAGTAGGGGGGGGGGGGATGT AAAGGAGTAGAGTTT--------------------------------------------- ------------------------------------------------------------ -----TTGTATGCAATTGAAATTAAGTTGTTATCAGTTTAAA------------------ ----------------------------------ATAG-------------ATTGTTATA ACTTTAAGATGTTTTATGTAATCCCCATGGTAACCACAGAGAAAATACCTATAGAAG--- ------------ATACACAAAAGAAAATGAGAAAG-----------GAATCAAAGCATGT CACTAC------AAAAAAATCAATGAAAAACAAAG----------AAAGGAAAAAAGGAA ----GAAAAGAGGAAAAAAAAAGCCATAAGACAT----AAAAAACAC-----AAATAACA ATACACAAAATAAACAATCAACTAA----------------------------------- ------------------------------------------------AATGACA----- --------------------ATATTAT--GTCA-TTCCCTATCAGTAA------------ -------------TTAC-TTTAAATG-TAAATGAATT--AAACAC---TCCA---AAAAG ACATAGAA--TGGCTGAA-TGGTT------------AAAAAAAAGCGAT----------- ---TAT-ACTAT----AAAGG-----ACTT-TAGAT--ATAAAAATACACATAAGCTGAA AG--TGAAAGGA--AAAAAAA-AGAAATTACATGCAAAAAG------TAAAA-------- -------------AAAAG-AAAGCAG--GGTTTGCTATACTAATATC------------- ------------------------------------------------------------ ----------AAA----------------------------------------------T AA------------------TATATATGCACCAAACATCAGAGC-----------TATAA AGCAAACATTGACAGAATTGAAGGGAGAAATAGACAATACTAC---------AATAATAG TAGGAGACTTCAATACCCCAC-----TTTAAATATTGAATAGA----------------- ----ACAACCAGAC------AGAA-----GATAAATAAGGAAAAAAAGGATTTG------ --AACAACACTATAGACCAATTGGAC-CTAACAG--ACATATACAGAA--CACTCCACCC AACAACAG---CAGAATACACATTCTTCTCA-------AGTGCACAT---GAAACATTCT C------CAAGATAAAACAAATTTTAAGCCACAAAAAAAG-------------------- -TCTTAACAAATTTAAAAAAA--TTGAAAT----------------AATAAAAA------ -GAATTTTTTCT---TATAACAATGGAA-TAAAACTAGAAATCAATAGCA--------AA A-------------GG-AAAATTG---GAAAATATAAAA----ATTAAAAAAAATAATAT ACAAAAAAACCTAAA---TA------TA----------AAAAAGAAAT--CAC-AAGGGA AATTAGAAAATATCTT---GAGAC------------------------AAATGAAAATGA -AAACACAAC--ATACCAAAAAATA-TGATAATGAAATAAAAGAAGTACTAAGAGGAAAG --TTTATAAATATAAATGTTTATATTAAAA---------A--AAGATCT---CAAATCAA ------TAACCTAACTTTACACCTCAA---GGAACTAAAAAA---AG---AAGAACAAAC TAAACCCA-AAGTTAGCA------------GAAGGAAGGAAATAAT-AAAGATTAGAGCA GAAATA---AATAAAATAGAAACTATAAAAA-------------AAATT-AAAAAAAAAA -AAAAT-------TGGTTTTTTGAAAAGATAAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGACAAACCC---TTAGCTA------GATT-------------- AACAAAGAAAAAA-----A--------AGACTCAAATAAC-------------------- -----TAAAA---T---------CAGAAATGAAAGA------GGAGA---CATTACAACT G--------ATGC-CACAGAAATA-AAAAGGATT--ATAAG---------AGAAT----- -------------------ACTATAAACAA-TTGTATGCCAACAA--AT---TGGATAAC CTAG---AAGAAAT--GGATAAATTCCT--A---GAAACA---------TAC-----AAC CTACCA------AGACTGAATCATGAAGAAATAAAAAATCTGAAC--------------- --------AGACCT------A------TAACTAGTAAGGAGAT----TGAAT--CAATAA -TCAAAAATCTCCCAAAAAAGAAAAG--CC-CAGGACC--AGATGGCTTCACTGGAGAA- TTCTA------------CCAAACATTT----AAAGAAGAATTAACA-CCAATC-----C- ----TTCTCAAACTCTTCCAA-------AAAATTA-AAGAAAAGGA-----------AAC ACTTCCAAACTCATTCTATGAG---------GCCAGTAT---TACCCTGATACC--AAAG C-----------------------CAGAC--AAAGACA-CTAC----AA---------AA AAAGAAAACT---------------------ACA------GACCAATAT--CCC----TG ATGAATATTGAT------------------------GCAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAACTC------------------AA--------------- ---------ACA-------------GCACATT---------AAAAGGATTATACA--CCA ----TGAC------------CAAGTGGGA-TTTATTCCTGGAA-TGCAAG---------- -------------GATGGTTC-AAC-----ATATAA----AAATCAATCAATGTA--ATA CACCAC---------A------TTAACAG----AATGAAGGACAAAAAC---CACATGA- ----TCATCTC---AATT----------GATGCAGA-AAAAG---CATTTGACAA---AA TTCAACAACCTTT------------------TCTTGA---------T-AAAAAC-ACTCA --ACAAACTAGAAATAGAAGAAAACT-----ACTT-AACAAAAT---------------- -----------AAAAGCCAT-ATAT-GAAAAGCCCACAGC-----------TAACAT--C ATACTCAATGGTGAAAA-A-----CTGAAAGC-TTTT---TCTTTAAGAT----CAGGAA CAAGGCAAGGATGC-------CCACTTT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTTCTATTCAA-CATA--GTATT---GGAAG TTCTAGCCAG--------AGCAATTAG------AAAAGAA---AAAAA--AATAAAAGAC ATCCAAATTGGAAA-------GGAAGAAGTAAAA--TTATCTCTG-----TTCACAGATG AC--ATGATCTTA-------TATGTAGAAAACCCT---------------AAAGA---TT CCACAA---------AAA--AACTGTTAGAACT---------AATAAA--------TAGT AAAAAGGT-------------------------ACAAAATAAAA--------------AC TCAAA--------------AAAAAAAT----TGGTTGTTTTTC--TA-----TTAA--CT ATGAACAATTCGA------------------AAAAGAAATTAAAA----AAAAAAATTCC AATTTCAATAAG-CACAAA---AAAAAAAAAATACTTAGGAATAAATTT--------AAC -CAAAAAGGTGAAAGACTTGT---ACACTGAA--AACTACAAAACATTGCTG-AAAAAAA TAAAAGA-----------AG------------------ACACACAAAT--AAATGGAAAG ATAT------C---CCGTGTTTATG------GATTGAAAGACTT-----AATT-TTTTT- ------------------------TAAATTTCCAATA-CTACCC-AA------------- ----AGCAATCTACAGA---TTCAATGCAATCCCTATCAAAAT---------CCCAATGA GT------------TTTTTT---------------------------------------- --GGAAGAAATGG---AAA------AATTAATCCTAAAA-TTCATATGAAA-------TC TCAAGGGACCCT---GA--ATAGCAAAAAAAATATTAAAAAAAAAAAAAA---AAAATGT -------GGAGGACTCACA---CTTCCTGATTTCAAAAC-----ATATTACAA---AGCT ACAGT-AATCAAAAA-AG------TGTGGTACTGG--CA-----------------TAAA GACAGACA------TATAGAC--CAATGGAATAGAATAGAGAGCCC------AG--AAAT AAA---CCCTCACATATATG----GTCAAA--TGATTTTT---AACAAG--GGTGC--CA AGACCACACAAATTGG-----GAAAAAA----AAAA---------CTCTT--TAAAAAAA AGGGTTG----------G-GAAAAACCTGG-A-TATCCA---------------TATGC- AAA---------AGA--ATGAAGTTGGACCCTT----ACTT---------------TACA CC--ATATACAAAAA-TTAACT-CAAAATGGATTAAAGACCTAAACATA--AGACCTAAA ACT-AT------------------------AAAACTCCTAGAA----------------- ------GAAA--ACATA------G---------AGG---------AAAACCTTCATGAC- --ATT-----GG-ATTTGGCAATGATTTCTTGGATAT-GACAACA-AAA----GCACAGG CAACAAAAACAAA----A------AT---AGAC--AAA-TGGGACTAC--AT-------- -------------------------------------------------------C-AAA CTTAAAAACTT-CTGTG---CATC-AAAGGAAACAATCAAC-AGAG-TGAAAAG-GCAAC CTAC--AGAA--T-GGGAG--AAAATATTT---GCAAATCATATAT--------CTGATA AGGGGTTAA-------TATCCAGAATATATA--AAGAA--CTCCT-----ACAAC----- ----------------------TCAACAACAA------AAAAAC---------------- AAACCCAACATTAAAAA----------AATGGGCAAA-----------GGA--CTTGAAT ---AGACATTTCTCCAAAGAAGATATACAAA--------------TGGCCAAC-AAGCAT ATGAAAAGATG----TTCAACATCACTAA-TCATTAGAGA-AAT--GCAAATC-AAAACC ACAATGAGA---------------------TATCACCTCACATCCATTAGGATGTCTA-- ----CTATAAAAA---AAAAAAACA---------AAATAACAA--GTG--TTGGT-G--- ---------------AGAATGTGGAGAA-------------------------------- -----ATTGGAACCCTTGT-GCACTGTTGG--TGGGAA---------------------- -------------TGGA-------------AAATG-GTGCAACC--------GCTATGA- -------AAAACA-TTATGAGG--GTTCTCTCAAAAAATTAAAA--ATAGAATTACCA-- -TATGA--TCCAGCAATCCCACTTCTGGG-TATATA-TCCAAAAGAAAT--TGAA----- -------------------AGCAGGAT-TTTGA--AGAGATATTTG----------C--- ---------ACACC--CATGTTCATTGCAGCAATATC---CAAAAGA----------T-G GA--AGCAACACACAAA-TGTCCATTG---ACAGATG-----AATGGATAAA--CAAAA- TG---------------------------------------------------------- --------------------TGGTATATAC----ATACAATAGAATAT--TATTCA-GCC TTAAAA----------------------AAAAAGGAAATTTTGTCACAT----------- ------------------------------------------------------------ -GCTACAACATGGATGAAC-C---T----------------TGAGGACATTATGCTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GTCAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAAG---- -----------------------------ACAAATAC-TAC------------------- --------------TAT-------------------------------------CTAAAG T-------A--------------GTCAAA---------------T--------------- ------------------------------------TCATA-------------GAAA-- -------CA------------------------------------------GAAAGT--- -AGAATGGTGGT---TGCCA-----GGGGCT------------GGGGGG----------- AGGGGGAAAAGG------------------------------------------------ --GGA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GTTGTTTG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------TTTAATG---------------------------------------------- --------GGTA----TAGATTTT------------------------CAGTTTTGCAAG ATGAAA--------------------------AAGTTCTGGAGATCTGTTGC-------A CAA-----------------------------------------------------CAAT GTGAATATATTT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACACTACTG-- ----------------------AACTGTACA--------CTTAAAAATGGTTAAGATG-- ------------------------------------------------------------ -----------------------------------------------------------G TAAAT------------------------------------------------------- ------------------------------------------------TTTATT------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TTATGTGTTTTTTACCATAA------TA- -------AAAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MB3 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AGAGAAA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TTCTGAAG----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------C------------------- ----------------------------TTAAAGGTAT---------------------- --------------------------------------------------AATAACTAAA ------------------------------------------------------------ -----ATGAAAAATC--------------------------------------------- ------------------------TACT-AGAGA-----------------GATTC---- --------------------------------------AAAG------------------ ----------------------------------------------------GCAGATT- -----TGAGC--AGGT------------------AGAAG---------AAAG-AAT-CAG AGTACTT----------------------------------------------------- ------------------------------------------------------------ ----GAAGATAGGACAATGAAAA-T--TATTAAG------CCTG---------AGAA--- ------------------ACAGAAAGAAAAA---AGA---TTAAAGAAAAG--------- TGA-ACAGAGCCTAAGG--AACATGTGGG-ACACCATC-----------AAGTA--GACC AACATACATA-TTGTTGG--AGTCCCAGAAA-----------------GGGAAAAAAAAA AAAAAGGGACAA---------AGAGAATATTTGA--A--------AAAATAATGGC-T-G AAAACTTCCCAAATTT--------------------GATGAAAGACATGA--ATATAAAC ATCC-----AAGAAGCTCAACAAAC---TCCAAGTAAGAT--------GAA--------- -----CTCAAAGA-----GACCCACACCGA----------------------------GA CACATTATAATCAAACT------GTC-AAAAG---------------ACA---------- ------------AAG--AGAGAATTT---------------------------------- --------TGAAAGCAACGAGAGA-----AGTGAC--------------TTATCAT---A TAC----------AAGG--------------GATCCTCAAT--AAGATTAT-C--AGCAG ATT--------TCTCATCAGAA--ACTTTG-GAGG--CCAG-AAGGCAGTGGACAGAAGG CAGTGGGCTAATATA-T-------TCAAAG--T-GATAAAAAAAAAACGAACAAAAAAAA AAAACTG--TCA--ACCAAGAA--------TTCTAT----------ATCTG--------- --GCAAAACTGTCC-----TTCA-AAAGTGA-------GGG-AGAAATTAAGACATTCCC AGATAAAC-AAAAGCTGAGGGA-GTTTATTACCACTAGAC---CTGCCCTAC-AAGAAAT GCT--------------AAAGGG----------------------AGTCC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TGCAT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ATTA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------AGAATCT----------------------------------------- ----GA--------------------------------AGAAAT--------ATCAGCGA ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TTACTTTAAATTAA------------ -------------TTAC-TT-------TAAATCGACTAAACCTAC---CACAATCAAAAG GCATAGAT--TGGCAGAA-TGGAT------TTTTATAAAAAAATAGCATCCAACTA---- ---TAT-GCTGTCTACAAGAG-ACTCAGTTTTAGAT--CTAAAGACACAAATAGTTTGAA AG--TGAAAGGA--TGAAAAA-AGATATGCCATGAAAATAGTATTATTAACC-------- -------------AAAAG-AGAGCAG--GGGTGGCTATACGGATATC-ACACAAAACAGA CTTTAAG-TC----------AAAAAAGCTTACAAGAGAC-AAAA-AAGGACATTTTAT-- ----ATTATTAAA---AGATACAGTACAGC--AAGAAGTACCAACAAGAATAACAATAAT AA-----------------ACATATATACACCAAATATCAGAGCATCAAA--ATATACGA AGCAAACATTGACAGAATTGAATGGAGAAACAGATAGCTCTAC---------AAGAACAG TAGGAGACATTAGCACTCCGC-----TTTCAATAATGGATAGAACAAGGAGACATAAGAT CCCCACATCCAGAC------AAAG-----AATCAATAAGGAAATAAAGAACTTG------ --AACAACACTATAAACCAATTAGAC-CTAACAG--ACATATACAGAA--TACTCCACCC AACAACAG---CAGAACACACATTTTTCTCA-------AGTGCACAT---AAAACATTCT C------TAGGATAGACCATATGTTAGGCCACAAAACAAG-------------------- -TCTTAATAGATTTTTAAAAACAGAGAAATGTATATATTTAGAAAACATAAAAA------ -GTATCCTTTTT---AACAAAGAATGGA-TAAAACTAGAAATCAGTAACA--------AA A-------------GG-ATAACTG---GAAAATTCGAAAA---TTATGAAAAATGTAAAC AATACA-CTCCTAAC---CA-ACCAATGATGGGTA---AAAGAAAAAT--CAC-AAAGGA AATTAGAAAATATTTT---GACATATGTAAATATATATCTTGTGACAAAAATAAAAATAA -AAACACAAC--TTACCAAAACTTA-CGG-GACGGAGTGAAAGCAGTGCTAAGAGAAAAA --TTTATAGCTATAAACACATACATAAAAAAAG---AAGA--AAGATCT---CAAATCAA ------CAACCTAATTTTACACCTTAA---GGAACTAAAAAA---AG---AAGAACAAAC TAAACTCA-AAGCTAGCA------------GAAGAAAGGAAATAAT-AAATATTAGAACA GAAATA---AGTGAAATAGAAAATAGAAAAA-CAA---TAGAAAAAATA-AACGAAACCA -AAAGT-------TTGTTTTTTGAAAAGATCAA--------------------------- -----------------------------------------------------------C AA-----AA------TTGACAAACCT---TTAGCTA------GATT-------------- GACTAAGAAAAAA---------GAAA-AGACAAAAATTAC-------------------- -----AAAAA---T---------CAGAAATGAAAGA------GAGGGGATCATAGTAACT A--------ATTT-TATAGAAATA-AAAAGGATA--ATAAA---------AGAGT----- -------------------ACTATGAACGA-TTATGTGCCAACAA--AT---TGGATAAT CTAG---ATGAAAT--GGACAAATTTCT--A---GAAACA---------CAA-----AAC CTACCA------AGACTGAATCATAAAGAAATAGAAAATCTGAAT--------------- --------AGACCT------ATAATTTTAACTAGTAAGGAGAT----TGAAT--CAGTAA -TCAAAATACTCTCAAAAAAGAAAGG--CC-ACGGGCT--GGAGTCTTTCATTAGTGAA- ATCTA------------CCG-----------AAAAAAGAACAGAAATCCAATC-----T- ----TCCCAAATCTTTTCAAA-------AAAATAG-AAGAGGATAG-----------AAC ACTTCCTACTCAATTCATTGAG---------GCCCACTT---TTTCCTTATACC--AAAA C-----------------------CAGAC--AAAGACA-CTAC----AA---------GA AAAAAAAATA---------------------ATA------GACCAACAT--CTC----TT ATGAACATTGAT------------------------GTAAAAATCC-TCAA--------- ------CAAAATACTAGC-AAAGTG------------------AA--T------------ ---T-CT--AAA-------------GCATATT---------AAAAGAATTATACA--CCA ----TGAC------------CAAGTGAGA-TTTATTCCTGGAA-TGCAAG---------- -------------GATGGTTC-AAC-----ATACAA----AAATCAATCAATGTA--ATA GTCCAC---------A------TTAACAG----AATGAAGGAGAAAAACCCACATATGA- ----TCATCTC---AATT----------GATGCAGA-AAAAG---CATTTGACAA---AA TTTAAACACCTTT-------------------TAAGATTAAAAAAGC-AAAAAA-ACTCA --ACAAACTAGGAATAGAAGGAAACT-----ACCTCAACTTAAT---------------- -----------AAAGGCCAT-GTAT-AAAAAACCCACAGC-----------AAACAT--C ATACTCAAAGATGAAAAAA-----CTAAAAGT--TTT---TCTCCAAAAT----TAAAAA CAAGACAAAGATGC-------CCACTTT-------------------------------- ------------------------------------------------------------ ------------------------TACCACTTCTATTCAA-CATA--GTACT---GGAAG TCCTAGCCAG--------AGCAATTAGGCAAATAAAAGAAAATAAAGA--AATTAAAAGC ATCAAAAAAGGAAA-------GGAAGAAGTAAAA--TTATCTCTG-----TTCACAGATG AT--ATAATCTTA-------TATGTAGAAAACCCT---------------AAAGA---TT TTTCCA---------TAA--AAATCCACAAAAA---------AATAAA--CAATTATAAT AAAG--TTAAAAAAAAAAAAACCCTGAAAATTGTTAGAATTGATAAATATATTCAGCAAA TCAACAC------------AAAAAAAT----TAATTGCATTTC--TA-TACACTAA--AA ATGAACAATTTAA------------------AAATGAAA-TTAAG----AAAACAATTCC ATTTACAATAGC-AACAAA---AAGAATAAAATACTTAGGAATAAACTT--------AAC -CAAGGAGGTGAAAGACATGT---ACAATGAA--AACTACAAAACATTGCTG-AAAGAAA TAAAAGA-----------AGACGGAAACACACACACACACACAAAAAT--AAACAGAAAG CAAA------T---TCATGTAAATA------AATGGGAAGACAT-----ATTA-ATATT- ------------------------AACGTGTCCA-TATGTCACC-AA------------- ----AATGATCTATAGA---TTCAATGCAATCCCTATCAAAAT---------CCCAATG- CC---------AATGTTTTT---------------------------------------- --TGTAGAAATAA---AAA------AACCCATCCTAAAA-TTCATATGGAA-------TC TCAAGGGACCCC---AA--ATAGCCAAAACAATCTTGAAAAAGAAGAACA---AAGC--T -------GGAGGACTCACA---CTTCCTGATTTCAAAAC-----TTACTACAA---AGCT ACAGT-AATCAAAAT-AG------TGTGGTACAGG--CA-----------------TAAA GACAGACA------TACAGAC--CAATGGAATAGAATAGAGAGTCC------AG--AAAT AAA---CCCTCGCATATATG----GTCAAA--TGATTTTT---GACAAG--GGTGC--CA AGACCATTC--AATGG-----GGAAAGG----ACAGT--------CTTTT--CAACAAAT GGTGCTG----------GGAAAAAC--TGGACATATCCA---------------CGTGC- AAA---------AGA--ATGAAGATGGACTCAT----ACCT---------------CATA AC--ATACACAAAAA-TAAACT-CAAAATGGATCAAAGACCTAAATGTA--AGAGCTAAA ACT-AT------------------------AAAACTCTTAGAA----------------- ------GAAA--ACATA------G---------GGC---------AAAAGCTTCATGAC- --ATT-----GG-ATTTGACAATGATTTCTTGGATAT-GACACCA-AAG----GCACAGG AAACAAAAGAAAA----A------AT---AGAA--AAA-TTGGACTTC--AT-------- -------------------------------------------------------TAAAA ATTTAAAATTT-CTGTG---CATC--AAAAAAACAATAAAA-AGAG-TTAAAAG-GCAAC CCAC--AGAA--T-GGGAG--AAAATATTT---GCAAATCATATAT--------CTGATA AGGGATTAA-------TATCCAGAATATATA--GAGAA--CTCCT-----AAAAC----- ----------------------TCAACAACAGACAATCAAAAAC------------A--- AACAACCCAA-TTCAAA----------AATGGGCAAA-----------GGA--CTTGAAT ---AGACATTTCTCCAAAGAAGATATACAAA--------------TGGCCAAT-AAGCAC ATGAAAAGATG----CTCAACATCACTAA-TCATTAGGGA-AAT--GCAAATC-AAAACT ACAATGAGA---------------------TACCACCTCACACCCATTAGGATGGCTA-- ----CTATTAAAAAAAAAATAGAAA-----CAGAAAATAACAA--GTG--TTGGC-G--- ---------------AGGATGTGGAGAA-------------------------------- -----ATTGGAACCCTTGT-GCACTGTTGG--TGGGAA---------------------- -------------TGTA-------------AAATG-GTACAGCC--------GCTATGG- -------AAAACA-GTACGGCG--ATTC-CCCAAAAAATTAAAA--ATAGAATTACCA-- -TATGA--TCCAGCAATTCCACTTCTGGG-TATATA-CCCAAAAG-AAT--TGAA----- -------------------AGCAGGGT-CTCAA--AGAGATATTTG----------T--- ---------ACACC--CATGTTCATAGCAGCATTATT---CACAATA-GCTAAAACGT-G GA--AGCA--ACCCAAG-TGTCCATCA---ACAGATG-----AATGGATAAG--CAAAA- TG---------------------------------------------------------- --------------------TGGTATATAC----ATACAATGGAATAT--TATTCA-GCC TTAAAA----------------------AGGAAGGAAATTCTGACACAT----------- ------------------------------------------------------------ -GCTACAACATGGATGAAC-C---T----------------TGAGGACATTATGCTAAGT GA-------------------------------------------------------AAT A----------------------------------------------------------- ----------AGCCA--GTCAC-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAGG---- -----------------------------ACAAATAC-TGTATG--------ATT----- ------CCACT---TATACTGAGGTCAAATAAAGGTACTAGAACTACATAT---ATTAAC ATTGATGAATCACAAAACCTAACGTTGAA---------------TGAAAACAGAAAGTCA CAGGAAAAAAAATGAATCCATTT-------------TTATGTAGGGTAAAACTGGGCAAA TAATAAACAATACATTGTTTAGAGATACATTCGTAAATGATAAACTTTAAGGAAAAACAA AGGAGTGATTAA---CACCG-----AATTCTGGA---------GAGCGGTAACTTTTGAT AGGTAGGGAGGG------------------------------------------------ --GGAAGTGATTGGGGTG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GGG---------GCGCACAGAGGACTT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------CTCTCTT---------------------------------------------- ----------------TTAAGCT-----------------------ATGAGGTAGGT--C TTGAGT--------------------------------------TTTCATCT-------- --------------------------------------------------------TATG ATTATTTTTA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AAACTCTGTG-- -------------------------TGTGTG--------T-------------TTGTG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TGTGCG-------------------------------TGTGTT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ACGAA--------------TAATACATTCCCCAATAAAA--------- -------AGAAT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MC3 -----------------------------------AAAGA------------AATAATGG CT---------------------------------------------------------- ---------------------GAGA---------------------------------AC AT--TTCCAA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AATAAATGA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CAGAAACC----------------------------------------- ------------------------------------------------------------ -----------AAACCACA----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------GATCCAAGAAGCT----- ---------------------------------CAGAGTGCAGCTCCTTG---------- CCAG---CAACAGAGCAAA-------GCA-GCAATAAAAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CAA-CTTTGACA AGTT------AACAAAAG----------------------------------ATCTAC-A CTAAGGATAAAAATATTCCAACT----GAAAGACTAAA---------------------- -----------------------------GACAGGACCCATTGC---AAAGAAGC----- ----------------------------------------T------------------- -------AAAAACCTTGAAAAAAGA---TTAGATGAATG--------------------- ----------------------GCTAA-------------CTAG------AATAACCAGT --------------------------------------GTAGAGAAGTCC---------- -----TTAAATGACC--------------------------------------------- ------------------------TGAT-GGAAC---TGAAA---------ACCAT---- -AGCACGAGAA----CTACGTGACGAATGCA-------CTAG------------------ --------------------------------------------CTTCAGTAGCCAATT- -----TGATC--AAGT------------------GGAAG---------AAAG-GGT-ATC AGTGATT----------------------------------------------------- ------------------------------------------------------------ ----GAAGATCA------TGAAA-T--GAAGCGA------GAAG---------AGAA--- ------------------GTTTAGAGAAAAA---AGA---GTAAAAAGAAA--------- TGA-ACAAAGCCTCCAA--GAAATATGGG-ACTATGTG-----------AAAAG--ACAA AATCTACGTC-TGATTGG--TGTACGTGAAA--------------GTGACATAGAAAATA ATAATGGAATGA---------AAAAAATATTTGA--A--------AAAATTATGGC-T-G AAGAATTTTCAAAAAT--------------------AAATAAAAAAAACA--AAACTCAA ATTC-----AGGAAACTCAGAGAAC---ACCAAGCAGGAT--------AAA--------- -----TACCAAAA-----TATCTACACCTA----------------------------GG CACATCATATTCAAACTGGGAG-----GAAAA-----------AAAACGA---------- ------------AAAACAAAAATTTTT--------------------------------- --------TAAAAGACGCCAGAAG---AAAAAAAC-----------------TTAC---C TAT----------AGAG--------------GAAAAAAAAT--AAGAATTA-C--AGTGG ACT--------TCTCATCAGAA--ACCAT--CAAA--AAAAAAAGAGAATG--------- ----TAA-AAATGTA-T-------TCAAA---T-GTT-TAAAGAAA-------------- -AATTATAATCA--ACAAAAAA--------TTCTAT----------ATCCA--------- --GCAAAATTATAC-----TTCA-AAAGTAA-------AGG-AGAAATAAAGACTTTCTT AGACAAAC-AAAAACTGAGAGA-GTTTATCACCAGCAGAA---CTGCTTTAC-AAGAAAT GTT--------------AAAAGAGGCTTTTAAAAACAAATCTATGAATTC---------- ------------------------------------------------------------ --------------------TTACCAGCTACTAAAAGATAATGCCAAAGCTAAAAGTAGT TCTTCAGGCAGAAAATTAATCAAGGAAAGGAAAGTTATATAGGTCAGAAACTCAAATCTA CTTAAATAATGGAAGAATGTTAAGTGTTTTCTTATTCTGAATTGATAACTGTTTGCTAAA TATAATAGTAATAATTATGTGATTATAAATTATAAATAATAGAAAAGAAAAAAAGAAAAA TAATAAAAAAAATGAAAATGAAAAATAGAAAATACAATTATAAAAAAACCTCACTTCCAT GTGAACTATATGAGTGTTGTTAGAGGTAGTTTTTATTGTATTTAAAGTTGTATAATATTA AAAGTAGCACCACAATCATTTATATAACTAAAAAAATATAATTGATATGCTAAGAAAAAA AATAAAATGGAATAACATAAAATGCTCAAGTAAAAGTAGAGAAGGCAGAAAAAGAGAGGA AAAAAAAAAAAGAAAAGAAAAAGTTCAAAAAATAGAAAACATTGAAAACATGGCATATAT TAATCCAACTATATCAATAATCACTTCAAATGTGAATGGTCTAAATTTATCAATTAAAGG CAACAGTTATAGGTGTGAATAAAAAACAAGCCAAAAATAAAAAACAAACAGACAAAAAGG TAAATGGTGTACAAGAAACCTAACTGATTGGTGGTTACAAACAAACTTTCATAATATAAA GATGTTGGAGAAATTGGGAATACTCTGTTATATGGTCTCTATACTATATTTGAAGTAGTA CAGTGTTATTTGAAAGTGGGCTTAGATTATTTTATGTGTATATGAATATACATTTCTATA TATAATAGTATGTTTATATTATATATA-------ATAG---------------------- ---------TGTATTTTATTTTATTTTAATATATATTTTTGAAAGAAATATAATTTATAT ACTAATACGCACATATAAAATAAGCCCTAAAGCAG-----------TGGCTAAGAGCATT TACAAA------AGAAAAATAGGTAAATGGAATAGAATAGAGATGAAAGAAGTATCCAAA ----TACAAAATTAAACAGTTAAAGGGCAAAAAAACAGAGAAAAAAAACAAAAGAAACAA AAAAGAAAAAACAATAGAGAATATTATACTTAGGAAAGCAGAAAATCAGTTACAAAA--- ------------------------------------------------CATGGTA----- --------------------AATATTA--ATAC-AAATATATTAATAA------------ -------------TCAC-TATAAATT-TGAATGGTCT--AAATAC---CACAATTAAAG- --ATAAAACTCTACAGAA-TAGAC------------ATAAAGAAAACATTCAACTAAAAA TGATGT-TTTGTCTACAAAAA-ATCTATTT-TAAAA--TCAAAAATAAAAAAAGGGTAAA AA--TAAAGAGA--TGGAGAA-AGATATACCATGTTAACAC------TAATC-------- -------------AAAAG-AAAGCTG--GAGTAGCTATATTAATTTC-AGACAAAACAGA TTTCAAA-AC----------AAAGAAAATTATCAGAAAA-AAAA-AAGGACATTAAAT-- ----AATGATAAA---AGGGACAATACAAC--AAGAAG--------AC-ATAACAATTTT TA-----------------ATATATATGTACCAATCAACAAAATATAAAA--ATACATGA GGCAAAAAATAATAGACATAAAAAAAGAAATAAACAAAAACAC---------AATTATAA TTGGAAACTTCAATAAACCTT-----TGACATTAATTGAAAAA----------------- ----TCAAAAAAAC------AAAA-----AATCAATAAAAATATAGATGACCTG------ --AACAGAACTATCAATCAAATTGAT-CTAAATG--AAATTTATAAAA--TACTCCATAC AAAAACAG---CAGAATACACATTCTTCTGA-------AGATTCCAT---GAAACATTCA A------CAAAATAGAAAATATTCTAGGCCATAAAACAAA-------------------- -CATCAATAAATTTAAAAAAA--TAAAAAT----------------AATACAAA------ -ATACTTAGACA---AAACACAAAAGAA-TTAAACTAGAAATCAATAACA--------GA A-------------AG-ATAGCTG---GAAAATTCCCAA----ATAATTGGAAACTAAAG AACAAA-TTTCTAATAAACA-AAAAATA--GAAAA---AAGAAAAAGT--CAA-AAGAGA AATTAAAAAATATTTT---GAACT------------------------AAATGAAAATAA -AAATATAAC--ATATAAAAAAATA-TGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------AATAA--AAAAATTAAAACA AAAATC---AATAAAATAAAAAAAAGAAAAA-AAA---TAAAAAAAATA-AAAAAAACCA -AAAGG-------TTGTTTTTTGAAAAGATCAA--------------------------- -----------------------------------------------------------T AA-----AA------TTGATAAACCT---CTAGCTA------GGCT-------------- AACCAAGAAAAAAAA---A---AAGA-AAAAACAAAAAAC-------------------- -----GAAAA---T---------AAAAAATGAAAAA------GAGGT---CATCACTATT G--------ATCC-CATGGAAATC-AAAAAGATA--ATAAA---------AGAATACAAT AAAATTAAAACTATGAAAAACTATTAAAAA-CTCTGTGCACATAA--AC---TTGATAAC TTAG---ATGAAAT--GAATCAATTTCT--T---GAAAAA---------CAC-----AAA CTTCCA------AAATTCACACAAGAAGAAATAGATAACCTGAAT--------------- --------AGGCCT------A------TATCTATTAAAGAAAT----TAAAA--TAATAA -TAAATAAACTTCCAAAAAAAAAAGC--AC-CCGGACC--AAATGGTTTTACAGATAAA- TTTTA------------CAAAAAATTT----AAGAAAAAAATAATA-CCAATT-----T- ----TCCAAAATCTTTTCAAA-------AAAATAG-AAACAAAAAG-----------AAT ACTAACTAAATCATTTTAAGAA---------ACCAATAT---TAACCATATACA--AAAA CACACTACAACTATCATAACACTAAAGATCAAAAGACATTTAAAGAAAAAAAATATACAA AAAAAAAATT---------------------ATA-------AACAATAAAAAC-----TA ATAAAAATAGAT------------------------GAAAAAATTC-TCAA--------- ------CAAAATATTAAC-AAATCA------------------AA--T------------ ---C-CA--AAA-------------AATTATA---------AAAAAAATTATACA--TCA ----TAAC------------CAAGTGGGA-TTTATTCCAGGAA-TGAAAG---------- -------------GCTGGTTT-AAA-----ATTTAA----AAATCAATCAATGTA--ATC CACTAT---------A------TCAACAG----ACTAAAGAAGAAAAAT---CATATGA- ----TCATATC---AATT----------GATGCAGA-AAAA------TTTAACAA---AA TTCAAAATCCATT-------------------TATG-------------AAAAA-TCTTA --GCAAAATAGGAATAAAAGAGAATT-----TTCTCAACTTTAT---------------- -----------AAAGAAAAT-CTAC-AAAAAACATCCAGT-----------TAATAT--C ATATTAAATGGTGAGAA-A-----CTGGATGC-TTTT---CCCTTAAGAT----TAAGAA CAAGGCAAGGATGT-------CCTCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTATTCAA-CATT--ATACT---GGAAG TCCTAGCTAG--------TGCAATAAG------ACAAGAA---AAAGA--AAAAAAATGT ATACAAATTGAAAA-------AAAAAAAATAAAA--CTGTCTTTA-----TTTACAGATG AC--ATGATTGTC-------TATGTAGAAAATCCC---------------AAAGA---AT TTACAA---------AAA--AAATTCTAAAACT---------AATAAG--TAATTATAAC AAGG--TC-------------------------ATAGGATACAA--------------GG TTAATAT------------AAAAAAAT----TAATTTCTTTCA--TA-TATACAAG--CA ATAAA-AAATTGA------------------AATATAAATATAAA--------------- ----ACAAT-------AAAAATTAAAATAAAAAAAATAGAAATAAAAAT--------AAA -AAAATATATACAAAATATAT---ATATAGAA--AACTATAAAACAATGATA-AAAGAAA TAAAAGA-----------AA------------------ATCT--AAAT--AAATGGAAAG ATAT------T---CTATGTTCATG------GATTGGAAGACTC-----AATA-TTGTT- ------------------------AAGATGTCAA-TT-CTTCCC-AA------------- ----CTTGATCTATAGA---TTCAATACAATCCCAATCAAAAT---------CCCAGCA- AG------------CTATTT---------------------------------------- --TTTAGATATTA---AAA------AAATTATTCTAAAA-TTTTTATTGAA-------AA GAAAAAGACCTA---GA--ATAGCCAACACAATACTGAAAAAAAAAA------AAGT--T -------GGAAGACTCACA---ATACCTAATTTCAAAAC-----TTATTATAA---AACT ATAAT-AATCAAGAT-AG------TGTGGTATTAA--AA-----------------AAAA AATAAACA------CATAAAT--AAA---AACAAAATAGAGAGCCC------AG--AAAT AGA---CCCACACAAATATA----GTAAAC--TGATTTTT---GAAAAA----GGA--AA AAAGCAATTCAAAAGA-----AAAAAGA----ATATT---------TTTT--TAAAAAAA TGTGCTT----------GAAAAAAT--TGG-A-TATCCA---------------TATGC- AAA---------AAA--ATAAAAATAGAAAAAA----AACT---------------TATA CC--TTTCACAAAAA-TTAACT-CAAAATGGATCATAGACCTAAATGTA--AAATGCAAA ACT-AT------------------------AAAACTTTTAAAA----------------- ------GAAA--ACATA------G---------AAA---------AAAATCTATGTGAC- --CTT-----GG-GTTTGGTGATGAGTTTTTAGATAC-AACACCA-AAA----ACAAAAA TCATTAAAAAAAA----A------AT---TGAT--AAA-TTGGACTTT--AT-------- -------------------------------------------------------TAAAA TTAAAAA-CTT-CTGCT---CTGT-AAAAGACACTGTTAAG-AGAA-TGAAAAG-ACAAG CCAC--AGAC--T-GGGAA--AAAATATTT---GCAAAACACATAT--------CTAATA AAGGACTTA-------TAAAAAAAATATATA--AAAAATTTTTAA-----AAAAA----- ----------------------ATAAAAATAA------AAAAAA------------A--- AAAAAAAAAAATAAAAA----------AATGGGCAAA-----------AAA--TCTGAAC ---AGACAACTCACCAAAGAAGATA--------------------TGGCAAAT-AAGCAT ATGAAAAGATG----CTCAACATCATTTG-TCATTAGGGA-AAT--GCAAATT-AAAACA ACAATGAGA---------------------TACCACTACATACCTATTAGAATGGCAA-- ----AAATGAAAA----------AA--------------------ATG--CTGAC-A--- ---------------AGGATGGAGAGCA-------------------------------- -----ACAGGAACTCTCAT-TCATTGCTGG--TGGGAA---------------------- -------------TGCA-------------AAATA-GTACAGCC--------ACTTTGG- -------AAGACA-GTTTGTGACAGTTT-CTTACAAAGCTAAAT--ATAGTCTTACCA-- -TATGA--TCCAGCAATTATACTCCTAGG-TATTTA-CCCAACTG-ATT--TGAA----- -------------------AACTTATT-TCCACA-ACAAAAACCTG----------C--- ---------ATACA--AATGTTTATAGCAGCTTTATT---CATAATT-ACCAAAAACT-G GA--AACA--ACCAAAA-TGTCCTTTA---ATAAGATAAGTGAATGGATAAA--AAAAA- TA---------------------------------------------------------- --------------------TGGTACATCC----ATACAATGGAATAT--TATTCA-GTG ATAAAA----------------------AGAAATGAAATATCAAAACAT----------- ------------------------------------------------------------ -AAAAAGGCATGGATAAATGCAAAT----------------GGAAAATGCCAAACTAAAG AA-------------------------------------------------------ACT ATTTTGAAAAGGAGGGAAATGATGTATAATAACATATTAACGAGTGAACACTGTTGGAAT GGGGAATGTCACACACTGGGGCCTGTTGTGGGGTGGGTGGAGGGGGGAGGGATAGCCTTA GGAGATATACCTAATGTTAAATGACGAGTTACTGGGTGCAGCACACCAACATGAATGAAT TATACATTTGTAACGTAACCTGCACATTGTGCACATGTACCCTAAAATTTAAAGTA---- -----------------------------TTAAATAAACACATA--------TTC----- ------AAGCTGTTTATAGCAGTTTTATTTATAACCTCCAAAAACTGGAACCCACCAAGA TGTCTTTCAACAGATCAATTAAGGAAGAAATTGATATATCCATGCAATGAACTGTTATTA GCAATAAAAAGAAATGGAATATCTTACCATGAAAGAACATGGATAAATCTTAAATGCA-- -------CATTTCTTAGTGAAATGACATTCTGGAAAAGGCAAAACTATAGAGACGGTAAA AAGATCAGTGGT---TGCCA-----GGGGTTTGG---------GGGGGG----------- -GGAGGGGAGGG--------------------------------TTGAATAGGTGAAGCA CAGGGGTTTTTTAGGGTGGTGAAACTATTCTGTATGATACTGTAATGGTGGATACATGAC ACTACATTTGTCAAAACCCATAGAACTTTACAGCACAAAGAGTGAACCTTAATGTATGCA AATTAAAAAAATCATTTAGGAGGTCGGGGGATCCCAGGATGGAATGCAGAATGTGACAAA ACAATCTAACTGTATTACAAATGTATGAAACAACCTCACTGAAGGGGGTGGGGGAAAAGG TGCTGACCTAAGTAACTTTGGAAATGAGTGGAGTCTGTAAGACTAAAGGCAAAAGGAACT GTACATAAGCACTGTACTCTAGTTGATAAAGTTGTTTCCCATGGGGGTATGGGTTAACAA TTCTGAAACCACTATACATGTATACTGGAATTGAACAATTAAGTAAATGGATGGCAGATG GTGGGAGCCAGGTTTCTCACTGTTGGAGTGGGAGGTTACAGATAAGCAAGGGGAGGAGGC TAGAATGATCCATGTGGTAATGGATTAGAGTTGGAGACATCAGTATGAACTCATGTTTAG CTTAATATAGATACAGATGGTTACATATAGAAATATTTATAGATATGTGTATATACATGG GTTAGTATACACACATATATTTCCTTGCTCTGTCAGCTGAGAGGGCCTAGAAGCAATGAC ACCCCAGTAGCAATGAGCACACCTAGTGCCCAGATCTTGGTTTCAATACCATTCTCCAAT AAAAGGAACCAGGGCTCCTTGGAGAAATGCTGATTCTAGGACTGGGGCAGGAAATATACA AGATGAGCCTGGAGCATCTTGTAGTGCCAGAAAGTAAGGAAGTGCTCAAAAAAAAAACAA AAACAAACACAAAACCCCACAATGATGGGGGTATGTCAAAGGGACACAGGAGCCAACTGA AAGAGCTCCCAATG----GCCAAAGCTGGAACAATTTGAAAATAAAGTAGTATTGGATTA TAACCCAAAGTATAAATAAATATCCATGAGTCCATACTGATAAATAAATGATTGAATAAA TTAAATGGGGGAGAAGAGACAAATCCCATGCAGAAGAATCCAAATAATTTAT-------G TAGATACTCCACCCTCAAGGAGGGGGTAACTCCCCACTCCTTAAGTGTGGGCTGTACATA GTGACTTCCTTCCAAAGAGTACAGTATGGGAAGGGGGGGAAAGAGTAACTTTACAGTGAG AAACCTGACAAACACTACCTCAGCCAGTGATCAAGGTCAACATCAACAGTGATAAGTCAT GTTGATAGTATGTACCCTTGATATGATGTGATGAAAATGGCACTTTACCTCTGTGGTCTT CCTCCAAAACCCATAACCCCAGTCTAATCATGAGAAAAACATCAGACAAATCCCAATTGA GGGACATTCTACAAAATACCTGACCAGTACT--------CCTCAAAACTG---TCAAGGT CATCAAAAACAAGGAAAGTCTGAGAAACTGTCACAGCCAAGAGGAGCCTAAGGAGACATG ACGACTAAATGTAATGTGGTATCCTGGATGGGATCCTGGAACAAAAAGGACATTAGGTAA AAACTAAGGAAATCTGAATAAAGTATGGACTTTAGTTAATAATAATGTATCAATATTGGT TCATTAATTGTAACAAA-------------------------------TGTACC------ ------------------------------------------------------ACTAAT GTAAGATGTTAATAATAGGGGAAACTGGGTGTGGGGTATATGGGAACTCTGTACTATCTT TACAAATTTTCTGTAAATC------------TAAAACTGTTCTAAAATAAA------AAG TTTTTTTAAAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MC1 -------------------------------------------------------TTTAG TTCCAGTTTTCT--GGCTTTCAGG------------------------------------ ---------------------TAAG---------GAGCTTCGAAGTTAC--------CAC TCCATCTTAACAACA-----AGTAAAAAGCTGAACAAACTGGAAAATCAACAACTCTTCT TAGA---------------------------------------------TCCGTAAGAGA A---------------------GTGAGGTCACAGGGCAAACCGCTG-------------- ----------CCCCCAAAATT-----------------GGAGAGACAGACAGGCAAATAC -------------AGGA---AATCCCAGTT----TCCGG----------------AACAA GAAC-----------------------------------------TCAGGAGCCAGAACC T-----------------------------------CCTCAGGAATCAGT----GCCGGG GTAGGA------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAACCTGAACTGTAATTGA----- -------------------CAAATTGTTGGAGGCTCA----------------------- -GTGTGGAGAGGTCTGAGAGT--------------------------------------- ------------------------------------------------------------ ------------TAAAAACTCGAGGAGGG--------------GGGCCCAGTCATG---- --------------------GGGGGGCCCCCACAA------------------------- ------------------------------------------------------------ -----------------------------TTTTGTGA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GTTTTTCCTCCAGGA-----------------------GCT TGACCAGG---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------TTCTCAC--AGTGAATATCGGAGA--------------------- ---------AAAATCCCCTCATG---------------------------------CTTC CGG----------------------CAGGGAG---------------------------- --------------------------------------------------------AGGG GAAAAGGAACCATTTTGAAATAC-----------------------------------AC CAGAGCATTC-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------TGTTCTTCTTAACAAGGCCT---------------------------------- ------------------------------------------------------------ ---GCCCTCAGGAGAAACTATTTTA------------------------------CCAGA GC----------------------------------------CTAACCTGCTGGGGTTTT ATCAGAGCT-----------------TAACCTACCTGGGGGAAGGGAAATA--------- --------------------------------------------------CCCAACTCCA GCCCC-------------CTCTA---------GCCA------------------------ ----------------------------------------TCCTGTCCCACCTAAGGG-- -----------GGGGGGGGGGAGAA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AGAGGAA------------------------------GGC T-----------GAGAAGCA---------------------------------------- ------------------------------------------------------------ ------------------CTTGTGAAGTTCACAGTCCAGGGGCACAGGCTCACT------ ------------------------------------------------------------ -----------AAAAGACT----------------------------------------- ------------------------------------------------------------ --GAGACCTAATCATAGGA----------------------------------------- ---CTATAGAACACTTCCCCC--------------------------------------- ------------------------------------------------------------ -------------CCCCCCACACCTTACCACC--------ACATTACTAAAGGCCTATTT ACCGCAGTTCCTTTTACCCAG------------TACATCATGTCCACCTT---------- TCAA---AAAAATTTCAAGACATACTACA-AAAAGGAAAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AAACACAGGTTG AAGA------GACAGAGC------AAGCA-------------TCAGAACCAGAGTCAGAT ATGGCAG---GGATGTTGGAATT----ATCAGACCAGG---------------------- ----------------------------AATTTAAAACAACTATGATTAATATGC----- ----------------------------------------T------------------- -------AAGGGCTTTAATGGAAAA----------------------------------- --------------------------------------------------AGTAGACAGC ----------------------------------------ATGCAAGAAC---------A GATGGGTAAAAAAAA--------------------------------------------- ------------------------TGCT-AGAGA---TCAAA---------AACAC---- -TGTAACAGAA----ATGAAGAATGCCTTTG-------ATGG------------------ --------------------------------------------GCTCATTAGTAGACT- -----GGACA--TAGC------------------TGAGA---------AAAG-AAT-CTC TGAACTT----------------------------------------------------- ------------------------------------------------------------ ----GAGGATATCTCAATAGAAA----CCTCCAAAACTGAAAAGAAAAGAATGAAAA--- ------------------GCAAAGAGAAAAA---AAACTGGTCAAAAATAA--------- AAA-ACAGAATATCTAA--GAAATGTGCG-ACAACTGCAGAAGACGTACAAAAAACATGT AACATATGTA-TAATGGG--AATACCAGAAA-----------GAAAAGAAAGAGAGAAAG GAACAG---------------AAGAAATATTTGA--A--------ACAATAATGACTT-A TAAATTTCCCAAATTA--------------------AAGTCAAAACACAAACCAAAGAAA ATCC-----AAGAAACTCAAAAAAC---ACCAAGCAAAAT-------------------- --------AAATG-----AAAATACACATA----------------------------GA CATATAATATTCAAATT-------ACAAAAAA---------TAAAAAATA---------- ------------AAA--AAAAAATTT---------------------------------- --------TGAAAGAAGCCAGAGAAAGAAAAAAAC--------------ACCTTAC---C TAT----------AGAG--------------GAGCAAAGAT--AAGAATTA-C--ATCTG ACT--------TCTCCTCAGAA--ACCATG-CAAG--CAAG-AAGAGAGTG--------- ----GAG-TGAAATA-T-------TTAAAG--T-GTT-GAGAGAAAAA------------ -AAA-CA--CCA--ACCTAGAA--------TTCTGT----------ACCCT--------- --GAAAAATTATCC-----TTCA-AAAGTGA-------AGG-AGAAATAAAGACTTTCTC AGACAAAC-AAAAATTGAGAGA-ATTTGTTGCCAGTAGAC---CTGCCTTGC-AAGAAAT GTT--------------AAAAGA----------------------AATTT---------- ------------------------------------------------------------ ------------------------------------------------------------ ----TTTTAGAAGAAAAAAAAAGGAAAATGATATAGGTCAGAAACTCAGATCTACATAAA GAAAGGAAGAGCATCAGAGAAGGAATAAGTGAAGGTAAAA-------------------- -----------TAAAAACTTTTTTTTTTCTTTTTTTTAATTGATTAACAGATAACAGTTT GTTCAAAATAATAATAGCAACAATGTATTTGATTATGTATGCTTATGTATA--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TATGTATATATATATATATAC ATATGTATGT-------------------------------------------------- ------------------------------------------------------------ ------TTATGTATAAGTGAAATGAATGACAGCAATGATACAAGGGACAGGAGGAAGGAA TTAGA------------------------------------------------------- -------------------------------------------TTATTTTGTTATTATAA GGTACTCGCACTACCCGTGAAGTGGTATAGTGTTATTTGAAA------------------ ----------------------------------GTGG-------------ACTTGGATT AGTTGTAAATGTATATTGCAAACTCTAGGGCAACCACTAAAAAAAGTTAAAAAAAAG--- -----AAGTATAACTGATATGCTAAGAAAGGAGAG-----------AAAATGGAATCA-- ------------TATAAAATGCT------C---------------AATTAAAACCACAAA ----AG------GCAGAAAAAGAGTGGAAGAC------AAAAATAGG-----AACAAAGA ACAAGGGCAACAAATAGAAAACAGTAACA---------------------------A--- ------------------------------------------------ATTGGTA----- --------------------GATATTA--ATCC-AACTATATCAATAA------------ -------------TCAC-TTTGAATG-TCAATGGTCT--AAATAC---ACCAATTAAAAG ACACAGATTGTGTCAGAG-TGTAT------------AAAAAAAAAAAAAACAAATAAATG ---TAT-TTTATATAAAAAAA-ACACACTT-TAAAT--ATAAAGACACATATAAATTAAA AG--TAAAAGGA--ATGAAAA-AAATATACCATGCTAACAC------AAATC-------- -------------AAAAG-AAAGCAG--AAGTAGCTATATTAATTTC-AGACAGAGCAGA CTTCAGA-GC----------AAGGAAAGTTATCAGGGAT-AAAG-AGGGGCATTACAT-- ----AATGATAAA---GGGGTCAATTCTAC--AAGAAG--------AC-ATAACAATCTT TA-----------------ATGTGTATGTACCTAACAACAGAGCATCAAA--ATATATGA GGCAAAAACTGATAGAACTACAAGGAGAAATAGATGAATCCAC---------TATTATAG TTGGAGACTTCAACACCCCTC-----TATCAGAAATGGACAGA----------------- ----TCCAGCAGGC------AGAA-----AATCAGTAAGGACATAGTTGAACTC------ --AACAACACCATCAATCAACTGGAT-ATAATTG--ACATCTATAGAC--TACTTCATCC AACAACAG---CAGAATACACATTCTTCTCA-------AGCTCACAT---GGAACATTCA C------CAAGATAGACCACATTCTGGGCCATAAAACACA-------------------- -CCTTAACAAATTTAAAAAAA--TAGAAAT----------------CATACAAT------ -GTCTGCTCTCA---GACCACAATGGAA-TTAAACTAGAAATCAATAACA--------GA A-------------AG-ATAGCTG---GAAAATCCCAAA----ATACTTGGAGATTAAAA AACACA-CTTCTAAA---TA-ACATATG--GGTCA---AAAAAAAAATCTCAA---GAGA AATTAAAAAATATTTT---GAACT------------------------AAATGAAAATGA -AAACACAAC--TTATCAAAATTTG-TGG-GATGCAGTAAAAGCAGTGCTTAGAGGGAAA --TTTATAGCATTGAATGCATATATTAGAAAAG---AAGA--AAGATCT---AAAATCAA ------TAATCTAAGCTTCCACCTTAG---GAAACTAGAAAA---AG---AAGAGCAAAT TAAATCCA-AAGTAAGCA------------GAAGAAAAGAAAAAAT-AAAAATTAGAGCA GAAATC---AATGAAATTGAAAACAGAAAAT-CAA---TAGAGAAAATC-AATAAAACCA -AAAGC-------TGGTTTTTTGAAAAGATCAA--------------------------- -----------------------------------------------------------T AA-----AA------TTGATAAGCCT---CTAGCCA------GGCT-------------- AAGAAAGAAAAAAAG---A---GAGA-AGACACAAATTAC-------------------- -----TAATA---T---------CAGAAATGAAAGA------GGGGA---CATCACTACA G--------ATCC-CATGGACATT-AAAAGGATA--ATAAA---------GGAAT----- -------------------ACTATGAACAA-CTCTATGCCCACAA--AT---TTGATAAC CTAG---ATGAAAT--GGACCAATTCCT--T---GAAAGA---------CAC-----AAT CTGCCA------AAACTCACACAAGAAGAAATAGACAATCTGAAT--------------- --------AGGCCT------A------TATCTATTAAAGAAAT----TGAAT--CAATAA -TTAATAACCTTCCAAAACAGAAAGC--AC-CAGGCCC--AGATGGGTTCACTGGTGAA- TTCTA------------CCAAACATTT----AAGGAAGAAATTATA-CCAATT-----C- ----TCTACAATCTCTTTCAG-------AAGATAG-AAGCAGAGGG-----------AAT ACTTCCTAACTCATTCTATGAG---------GCCAGCAT---TACCCTAATACC--AAAA C-----------------------CAGAC--AAAGACA-TTAC----AA---------GA AAAGAAAACT---------------------ACA---------AAATAT--CTC----TC ATTAACATAGAT------------------------TCAAAAATTCTTCAA--------- ------CAAAATATTAGC-AAATTA------------------AA--T------------ ---C-CA--ACA-----------ATGTATATA---------AAAAAAATTATACA--CCA ----CGAC------------CAAGTGGGA-TTTATTCCAGGTA-TGCAAG---------- -------------GCTGGTTC-AAC-----ATTTAA----AAATCAATTAATGTA--ATC CATCAC---------A------TCAACAG----GCTAAAGAAGAAAAAT---CACATGA- ----TCATATC---AATA----------GATGCAGA-AAAAG---CATTTGACAA---AA TCCAACACCCATT-------------------CATGA---------T-AAAAAC-TCTCA --GTAAACTAGGAATAGAGGGGAACT-----TCCTCAACTTGAT---------------- -----------AAAGAATAT-CTAC-AAAAAACCTACAGC-----------TAACAT--C ATACTTAATGGTGAGAA-A-----CTAGAAGC-TTTC---CCACTAAGAT----CAGGAA CAAGGCAAGGATGT-------CCCCTCT-------------------------------- ------------------------------------------------------------ ------------------------CACCACTCCTTTTCAA-CATC--ATACT---GGAAG TCCTAGCTAA--------TGCAATAAG------ACAAGAA---AAGGA--AATAAAAGGT ATACAGATTGGGAA-------GGAAGAAATAAAA--CTGTCTTTG-----TTTACAGATG AC--ATGATTATC-------TATGTAGAAAATCTA---------------AAAGA---AT CAACAA---------AAA--AACTCCTGGAACT---------AATAAG--CAATTATAGC AAGG--TT-------------------------GCAGGATACAA--------------GG TTAATAT------------ACAAAAGT----CAATCACTTTCC--TA-TATACCAG--CA ATGAACAAGTGGA------------------ATTTGAAA-TTAAA----AACACAATACC ATTTACATTAGCACCCCCA----AAAATGAAATACTTAGGTATAAATCT--------AAC -AAAATATGTACAAGATCTAT---ATGAGGAA--AACTACAAAACTCTGATG-AAAGAAA TCAAAGA-----------AG------------------AACT--AAAT--AAATGGAGAG ATAT------T---CCATGTTCATG------GATAGGAAGACTC-----AATA-TTGTC- ------------------------AAGATGTCAG-TT-CTTCCC-AA------------- ----CTTGATCTATAGA---TTCAATGCAATCCCAATCAAAAT---------CCCAGCA- AG------------TTATTT---------------------------------------- --TGTGGATATTA---ACA------AACTGATTCTAAAG-TTTATATGGAG-------AG GCAAAAGACCCA---GA--ATAGCCAACACAATATTGAAGGAGAAGAACA---AAGT--T -------GGAGGACTGACA---CTACCTGACTTCAAGAC-----TTACTATAA---AGCT ACAGT-AATCAAGAC-AG------TGTGGTATTGG--CA-----------------AAAA AATAGACA------AATAGAT--CAATGGAACAGAATAGAGAGCCC------AG--AAAT AGA---CCCACATAAATATA----GTCAAC--TGATCTTT---GACAAA--GGAGC--AA AGGCAATAC--AATGG-----AGAAAAG----ATAGT--------CTTTT--TAATAAAT GGAG---------------AACAAATAAAG-A-TATACA---------------CACAA- AAA---------AAAAAATGAATCTAGACACAG----ACCT---------------TACA CC--CTTCACAAAAA-TTAACT-CAAAATGGATCATAGACCTAAATGTA--AAATGCAAA ACT-AT------------------------AAAACTCCTAGAA----------------- ------GATA--ACATA------G---------GAG---------AAAATCTAGATGAC- --CTT-----GG-GTTTGGCAATGACTTTTTAGATAC-AACACCA-AAG----GCACAAT CCATGAAAGAAAG----A------AT---TGAT--AAG-CTGGACTTC--AT-------- -------------------------------------------------------TAAAA TTAAAAA-TTT-CTGCT---CTGC-AAAAGACAATGTCAAG-AGAA-TGAAAAG-ACAAA CCCC--AAAA--T-GGGAG--AAAATATTT---GCAAAAGACATAT--------CTGATA AAGGACTGT-------TATCCAAAATATACA--AAGAACTCTTAA-------AAC----- ----------------------TCAACAATAA------GAAAAC------------A--- AACAACCTAA-TTAAAA----------AATGGGCCAA-----------AGA--CCTTAAC ---AGACACCTCACCAAAGAAGATATACAGA--------------TGGCAAAT-AAGCAT ATGAAAAGATG----CTCCACATCATATG-TCATCAGGGA-AAT--GCAAATT-AAAACA ACAATGAGA---------------------TACCACTACACACCTATTAGAATGGCCA-- ----AAATCCAGA---ACACTGACA-----------ACACCAA--ATGCTGTGGT-G--- ---------------AGGATGTGGACAA-------------------------------- ------AAAGAACTTTCAA-TCATTGCTGG--TTGGAA---------------------- -------------TGCA-------------AAATG-GTACAGCC--------ACTTTGG- -------AAGACA-GTTTGGCA--GTTT-CTTACAAAACTAAAC--ATACTCTTATCA-T ATATGA--TCCAGCAATCATGCTCCTTGG-TATTTA-CCCAAATGAATT--GAAA----- -------------------ATTTATGT--CCAC--ACAAAAACCTG----------C--- ---------ACATA--GATGTTTATAGCAGCTTTATT---CATAATT-GCCAAAACTT-G GA--AGCA--ACCAAGA-TGTCCTTCA---GTAGGTG-----AATGGATAAA--TAAAC- TG---------------------------------------------------------- --------------------TGGTACATCC----AGACAATGGAATAT--TATTCA-GCG CTAAAA----------------------AGAAATGAGCTATCAAGCCAT----------- ------------------------------------------------------------ -GAAAAGACATGGAGGAAA-C---T----------------TAAATGCATATTACTAAGT GA-------------------------------------------------------AAG A----------------------------------------------------------- ----------AGCCA--ATCTG-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAGG---- -----------------------------CTACATAC-TGTATG--------ATT----- ------CCAAC---TAT-------------------------AATGACATT---CTGGAA A-------A--------------GGCAAA---------------A--------------- ------------------------------------CTATG-------------GAGA-- -------CA------------------------------------------GTAAAA--- -AGATCAGTGGT---TGCCG-----GGGGTTG-----------GGGGGG----------- ----AGGGAGGG------------------------------------------------ --ATG----AATAGGCAG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGC-ACAGAGGATTTTAGGGCAGTGAA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ACTACTC---------------------------------------------- --------TGTA---------------------------------TGATACTATAAT--G GTGGAT---------ACATGTCATTATACATTTGTCCAAACCCATAGAATGT-------A CAA-----------------------------------------------------CACC AAGAGTG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCCTAATG-- ----------------------TAAACTATGGCTTTGGGTGATAATGATGTGTCAATG-- ------------------------------------------------------------ ------------------------------------------------------------ TAGGTTCATCA------------------------------------------------- ------ATTG-TACAAA-------------------------------TGTACC------ ---------------------------------------ACTCTGGTGGGGGATGTTGAT AGTGGGGGAGGCTGTGCATGTGTGGGGGCAGGGGGTATATGGGAAATCTCTGTACCTTCC GCTCAATTTTGCTGTGAAC------------CAAAACT----GCTCTAAAA------AA- -------AAAAGTTTTTT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---- >L1MC2 ---------------------------GGGGAAACTGAGGTA--CCCGACT-TCTGCTCA CACTAGACTTCC--TGCTTCAC--------CTAAGAGAAGAA------------------ ---------------------ATAC---------CTGAGAAGCACTTGT--------GAA GG--TCACAGCCAGA-----AGGGCACAGCCACCCTGAATGACA-----------GAGCT CTAA---TCATAGGATTACAGAGCACTTTCCACTG--------------CCCACACCTTC CCACCACATCAGCGGGGCTCCTGAATAATAACAAGGCTTTACAGAA-------------- ------------------------------------------------------------ ----------------------CTGCAAGC----CTCAGACACTACT-----TA-AGAAG GAG--------------------------------------------------------- --------------------------CCTCTAAGAAAACCCAGAGATAAC-------AGA GGAGAC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AAAACCAAGGATATTAGAAGAAATTTCTAG----------- ---------------AGGAAA--------------------------------------- -------------------------------------------------TTCTAAACTAT AACAAATAAAAATAAAGATAACAATAAAA--------------ACAACAAAATCAT---- -------------------AAAAAGATAAACATAA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AATCTAACATT-----------------------AAA GGAATATTTAT------------------------------------------------- --------------------------------------CATCTAATA------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------CTTTGTA--TAGCGTTTTCTAAAAAAATTAAAAAAGCGTCA---- ---------AAAAGAGAAAGAAG--------------AGTTTGAATAATCAAAGTAATAT CAG-----------------------------AATCGGAATTCAAAACAG---------- ------------------------------------------------------------ ---------TC---ATGGTTTTTAAAATGTAGGGGACGTCAAA---------------AT AAATAGAAAC--ATTCTAACATTAAAAAAGCACACCGGATA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AAAGAAAAAG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------GACGTATGGAG-------------------------------AACCTA GCAAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AAATCAA------------------------------TAC C-----------AAAAAGCAA--------------------------------------- ------------------------------------------------------------ ------------------------------------CAAAAGGATATGCAAGACATC--- ------------------------------------------------------------ -----------AAAAACAC------TGTAACAGGAATGTAACAT---------------- -----------GCCTTTGATAGA------------------------------------- --ATCATCAGTAGACTGGA------CAGGAACTA-------------------------- ---GAAAAGAATCAATGAGCT--------------------------------------- -----------------------TGTGGTCATGTGAATGGGAAC---------------- ------TTTCCAAACTGAGATGCAAAGAG----------AAAAAAATGTAAAAACAAAGG ATTACAATATTCT-----AGA------------ACTATCGGAGATTTTAAATGTGTAAAT CGAA---TGCCACCATAAA-------GAG-TAGAAGAAAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGA-AATTGAGT AATG------AGCAGAAAGGATAGTAATAATATGAAATACTTCCAGTATTAAATTACTGA TTACAAAATCGTATCAAAGAACCAGGAATACTAATAGG---------------------- --------------------CAATCCACTATCAAAATATAAAAT---AACGAAAC----- ----------------------------------------T------------------- --------AAAATAATGAATACAAG---AATGACAACAA--------------------- ----------------------GAAAAGAACTACCCCCTCTAGATACAGAGTTAAACACT -------------------------AAATTCAAAATTTCAAAAGGCAAGCAAACTATAAT AATGTTAGAAGGAAGGGAGGTTG------------------------------------- ------------------------TACA-AGAGA---TCAAA---------AACAC---- -TGTAACAAAA----ATGAAGAATGCCTTTG-------ATGG------------------ --------------------------------------------GCTCATCAGTAGACT- -----GGACA--TGAC------------------TAAGA---------AAAG-AAT-CAA TGAGCTA----------------------------------------------------- ------------------------------------------------------------ ----AAGGATATATCAACAGAAA-T--CTCCAAA------GTGG---------AAAG--- ------------------CAAAAAAGAAAAA---AAA---ATTAAAAG------------ TGA-AGAAAATATAATA--GAACTATGGA-AGAACTAC-----------AAAAG--GTAT AACATATGTA-TAATGAA--TGGACAAAACG--------------GAAA---GGAAAAAG AAAAAGGAACAG---------GAAAAATATTTGA--A--------ATAATAATGGC-T-G AAAATTTTCTAAAATT--------------------AATGACAGACACCAAACCACACAG ATCC-----AGGAAACATAGAGAAC---ACAAAA-TAAAA--------ATA--------- ---AATAACAAAA-----AAAATACACCTA----------------------------AG CACATCATATTCAAACT------GCA-GAAAA---------TAAAAGACA---------- -----------------AAAAAATCT---------------------------------- --------TGAAAGAAGTCAGAGG---AAATAAAC--------------ACATAAC---C TAT----------AGAG--------------GAACAAAGAT--AAAAATTA-C--ATCAA ACT--------TTTC---AGAA--ACCATG-CAAA--C----AAGAAGATG--------- ----GAG-TGAAATA-T-------TTAAAG--T-GTT-GAAAGAAAAA------------ -AAA-AT--CCA--ACCTAGAA--------TTCTGT----------ATCCA--------- --GTAAAATTATCC-----TTCA-AAAGTGA-------AAG-AGAAACAAAAACTTTCTC ACAAAAAT-ATAAATTAAAGGA-AATTGGTGGAAGTACAT---GGATCTTGC-AAGAATT ATTTAGTTCTTCAGAGAGAAGGGAAATGATATAGGTCACAAACTCAGATC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TACAT----------------AAAGAAAGGAAAAACATTGGGGAAGGAA AAAATGAAAGGTAAAAACAAAATATTTTCTTTTTATATTCTTAATTGATCT--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AACAGATAAGTTTTTTCAAAG TAA--------------------------------------------------------- -----------------------------------TAATAGTAACAATGTATTGGGTAAT TATAGTTTATGGATAAGTGAAATAAATGACAGCAATGTTATAAGAAAAGGGGGAAAGAAT TAGGAA------------------------------------------------------ ------------------------------------------------------------ ------------------------------TACTCTGTTATAAGGTACTTGCATTACCCA TAAGTAGTATAGTGTTATTTTAAAGTGGACTTAGATTA---------------------- -GTTGTAAATGTATATTGCAAACTCTAGGGCAACCACTAAAAAATTTTTTAAAAAAAA-- ------------ATTGAAATGCTAAGAGAAGAGAG-----------AAAATGGAATCA-- ------------TATAAAATGCT------C---------------AATTAAAACCAGAGA ----AG------GCAGAAAAAGAGTGGAAGGCAAAATAAAAAAAAGA-----AACAAAGA ACAAGGGCAATGAATAGAAAACAGTTACACATATGGTAAATTATTAATCCAACTATA--- -------------------------------TTAATAATCACTTTAAATATGGTA----- --------------------GATATTA--ATCC-AAATATATCAATAA------------ -------------TCAC-TTTAAATG-TGAACAGTCT--AAATAC---ACCAATTAAAAT ACAGAGAC--TGTCAGAAGTAGATTTT---------AAAAAAACTAGACCCAACTGTACA CTGTAT-ATAGGTTATAAGAA-ATCCACTT-TAAAT--ATAAAGACAGAGATACAGTTAA AAGTTAAGGGAATATGGAAAA-AGATATATCATACTAACGC------TAATC-------- -------------AAAAGAAAAGCCG--AAGTAGCTATATTAATTTCAAGATAAAGCAGA CTTCAGA-GC----------AAGGAAAATTATCAGGAATAAAAG-AGGGGCATTACAT-- ----AATGATAAA---AGGATCAATTCTCC--AAGAAG--------AC-ATAACAATCCT TA-----------------ATGTGTATATGCCTAATAACAGAGCATCAAA--ATACATGA GGCAAAAACTGATAAAACTACAAGGAGAAATAGATGAATCTAC---------TATTATAA TTGGATATTTCAATACTCCTG-----TTTCAGTAATTGACAGA----------------- ----TCCAGCAGGC------AGAA-----AATTGGTAAGGATGTAGTTGAACTG------ --AACCGCTTAATGAATCAACAGGAT-CTAATTG--ACATTTATGGAA--TATATCATCC AACAACAAAAGCAGAATACACATTTTTCTCA-------AGTTCACAT---GGAACATTCA T------TAAGATAGACCACATTCTGGGCAATAAAAGAAA-------------------- -GCTTAACAAATTCAAAAGAA--TAGAAAT----------------CATACAAA------ -ATATGTGCTTAGAGGACCACAATTGAA-TTAAATTAGAAATCACTAATACATACCAAAT ATTTACAGATAGCTGGAATCTTAG---AAAAATTCTAAA----CATAATGGAGATTAAAC AACACA-CTTCTAAAATCAA-ACATATG--ACTCA---AAGAAGAATC--TCA--AGAAA AATTAAAAACTATTTT---GGGCT------------------------AAATGAAAATGA -AAATACAAT--ATATCAAAATTTC-TGG-TATGCAGCAAAAACAGTGCTTAAAGAGAAA --TTTATAGCATTGAATGCATATATTAGAAAAG---AAGA--AAAACCTCTGAAAATAAA ------TAATCTAAGCTTCCACATTAGGAAAAAACTAGAAAA---AG---AAGATCAAAT TAAATCCA-AAGTAAGCA------------GAAGAAAAGAATTAAT--AAATTTAGAGCA G--------AAAAAAATGAAAATGCAGAAAT-CAA----CAGAAAAATC-AAAAAAACCA -AAAACTGGTTCTTGGTTTTTTAAAACGATCAA--------------------------- -----------------------------------------------------------T AA-----AA------TTGATAAATCT---CTAGCCAGGTTTTGGCT-------------- AACCAAGAAAAAAAG---AGAGGAGA-AGACACAAATTAC-------------------- -----TAATA---T---------CAGAAATGAAAGA------GGGAC---CATCACTACT G--------ATCC-CATGGACATT-AAAAGGATA--ATAAATAAAAAAAAGGAAA----- -------------------ATTATGAAAACTCTCTCTACCTCAAATTAT---TTAATAAC TTAGATAAGGAAAT--GGCCCAATTCCT--T---GAAAGAACTATCTACCAC-----AAT CTACCAAACTCTAAACTCACACCAGGAGAAATAGATAATCTGAAT--------------- --------AGGCCTATATACATATATATATCTATTAAAGAAAT----TGAAT--CAATAA -TTAATAACCTTCCAAAACAAAAAGC--AC-CAAGCCC--AGATGGATTCACTGACAAA- TTCTA------------CCAAATATTT----AAGGAAGAAATTATA-CCAATT-----C- ----TATATAATCTCTTCCAA-------AAAATAGTAAAGAGAAGAATTTCTAATGTAAC ACTTTCTAACTCATTCTATGAG---------GCCAGCAT---TACCCTAATACCAAAAAA A-----------------------CAGAC--AAAGACA-TTAC-----A---------AG AAAGAAAACT---------------------ATACAGACAGACCAATAT--CTC----TC ATGAATATAGAT----------------------ACGCAAAAATCC-TCAA--------- --CAAAAAAAATATTAGC-AAATCA------------------AA--T------------ ---C-CA--AGA-------------ATATAA----------GAAAGAATTATACA--CCA ----TGAC------------CAAGTGGGA-TTTATTCCAGGTA-TGCAAG---------- -------------GCTGGTTC-AAC-----ATTTGA----AAATCAATTAATATA--ATC AATCACTACCCTGTAA------TCAACAG----GCTAAAGAAGAAAAAT---CACATGA- ----TCATC-----AATATAG-------AATGCGGA-AAAAC---CATTAGCCAA---AA CCAACCACCCATT-------------------CATAT---------TAAAAAAT-TCCCA GTACAAACTAGGAATAGAGGAAAACT-----TCCTCAACTTGATAAAGAAGGAAACTCCC TCAACGTGATAAAGAATTAT-CTA--AAAAAACCTACAGC-----------TAACAT--T CATCTTAATTGTGAGAA-A-----CTAGATGC-TTTC---CCACTAAGAA----TAGGAA CAAGACAAGGATGTCCCATCACCCCTCTCACCACTCCTCGCGACCTCATCACCTCCCAAA GGCCCCACCTCTTAATACTATTGCACTGGGGATTAAGTTTTCAACAGTATGAATTTTGGA GGGACACACGCATTCAGACTATAGCACCACTCCTATTCAA-CATC--CTACTGAAGGAAG TCCTAGCTAA--------TGCAATAAG------ACAAGAA---AAGAA--AATAAAAAGT ATACAGATTGAGAA-------GGAACAAATAAAA--CTATCTTTGTTCTTTTCACAGATG ACAGATGACATTT-------TATGTAAAAAATCCACC-------------AAAGA---AT CAACAG---------AAA--GACTCCTGGAACTAATACCTGCAATAAG--TGATTATAGA AAGG--TT-------------------------GCAGGATACAA--------------GG TTAATAT------------ACAAAAGT----CATTT-CTTTCC--TATTATACCAG--CA ATGAACAACTGGA------------------ATTTGAAA-TTAAA----AATGTAACACC ATTTACATTAAC-ACCACCCCCAAAAATGGAAAAACTAAGTATTAATTTTAAATATAAAC AAAAATATGTATTAGATCTAT---ATAAGGAA--AACTATAAAACTCTGATG-AAAGAAA TCAAAGA-----------AG------------------ATCT--AAAT--AAATGGAGAG ATAT------T---CCATGTTCACGGATATAGATAGGAAGACTC-----AATA-TTGTC- ------------------------AAGATGTCAG-TT-CTTCCC-AA------------- ----CTTGATCTATAGA---TTCAATGCAATTCCAATTAAAAT---------CCCAGCA- AG------------TTATTT---------------------------------------- --TGTGGATATGA---ACA------AACTGATTCTAAAG-TTTATATTAAAAGGCTATAT GCAAAAGACCCA---GA--ATAGCCAACACAATACTGAAGAAGAAAAACA---AAGT--T -------GGAAGACTGACA---CTACTCAAATTCAAGACATATTATACTATAA---AGCT ACAGT-AATCAAGAC-AG------TGTGGTTTTGC--GA-----------------TAAA AGAATAAT------AATAAAT--CAATGGAACTGAATAGAGAGCCC------AG--AAAT AGA---CCCACACAAATATA----GCCAAC--TGATCTTT---GACAAA--AAGGAAGCA AAGACAATT-CAATGA---AAAAAAAGGATAAATTTCTTTATAGTCTTTT--CAACAAAT GGTGTTG----------G-AACAAC--TGG-A-CATCCAATGCCCCTCCTCCTACATGC- AAA---------AAAAATCAAATCTAAACACAT----ACCT---------------TACA CTATTT-CACAAAAA-TTAACTACAAAATGGATCACAGACCTAAATGTA--AAATGCAAA ACT-ATAAACTGTAATAAAAATAAAAAAAAAAAACTCCTAGAA----------------- ------GATA--ACATAAAAGAGG---------AAA---------AAAATCTAGGTGAC- --CTT-----GG-GTTTGGCGATGAGTTTTTAGATAG-AACACCA-AAA----GCACTAT CCACGAAAAAAAA----A------ATAAACAAT--AAGTTGGAAATTATTAT-------- -------------------------------------------------------TAAAA TTAAAAA-CTT-CTGCT---CTGT-GAAAGACACTGTTAAG-AGAA-TGAAAAAGCCAAG CCA---AGAGACT-GAGAG--AAAATATTTGTCGCAAAACACATAT--------CTGATA AAGGATAAAGGACTGTTATCCAAAATATACA--AAGAACTCTTGAAAAT-ACAAAAATTC CGAGATCACATCACTGCAAAACACAACAATAA------GAAAAT------------AAAA AATGACATAT-TTAAAA----------AATGGGCAAA-----------AGA--TCTGAAC ---AGACATCTCACCAAAGAAGTTATATAGA--------------TGGCAAAT-AAGCAT ATGAAAAGATA----CTCAACATCATATG-TCATTAGGGA-ATT--GCAAATT-AAAACA ACAATAGGAGATGGAGATACAACTACACACTACTATTACATACCTATTAGAATGGCTA-- ----AAATCCAAA---GCACTGACA-----------ACACCAA--ATG--CCGGC-G--- ---------------AGGATGTGGAACA-------------------------------- -----ACAGGAATTCTCAT-TATTTGTGGG--TGGAA----------------------- -------------TGCA-------------AAATG-GTATACCCACTTTGGAACTTTGG- -------AAGACA-GTTTGGCA--GTTT-CTTACAAAGCAAAAC--ATACTCTTACCA-A ATACGA--TCCAGCAATCATGCTCCTTGG-TATTTA-CCCAAATG-AGT--TGAA----- -------------------AACTTATG-TCCAC--ACAAAAACATG----------C--- ---------AAATA--AATGTTTATAGCAGCTTTATT---CATAATT-GCCAAAACGT-G GA--AGCACAACCAAGA-TGTCCTTCA---ATAGGTG-----AATGGATAAATTGAAAC- TG---------------------------------------------------------- --------------------TC------------ATACAATGGAATAT--TATTCA-GTG ATAAAA----------------------AGAAATGAGCTGTCAAGCCAT----------- ------------------------------------------------------------ -GAAAGACAATGGAATAAC-C---T----------------TAAATGCATATTACTAAGT GA-------------------------------------------------------AAG A----------------------------------------------------------- ----------AGCCA--ATCTG-------------------------------------- ------------------------------------------------------------ --------------------------------------------------AAAAGG---- -----------------------------CTACATAC-TACATACTGTATGATTC----- ------CAACT------------------------------ATATGACATT---CTGGAA A-------A--------------GGCAAA---------------A--------------- ------------------------------------CTATA-------------GAGA-- -------CA------------------------------------------GTAAAA--- -AGATCAGTGGT---TGCCA-----GGGGTTT-----------GGGGGG----------- ----GGGGAGGG------------------------------------------------ --ATG----AATAGGTGG------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------AGCACAGGGGATTTTTAGGGCAGTGAA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ACTATTC---------------------------------------------- --------TGTA---------------------------------TGATACTGTAAT--G GTGGAT--------ACATGACATTATGCATTTGTCAAAACCCATAGAACTGT-------A CAA-----------------------------------------------------CACA AAGAGTG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AACCCTAATGTA AACTATGGACTTTAGTTAATAATAATGTATCAATATTGGTTCATCAATTGTAACAAAT-- ---------------------------------GTACCACACTAATGCAAGATGTTAATA ATAGGGGAAATTGTGTGGGGGGGGGGGGGAGGGGGGGGATGGAAGAAGGAGGGGAAATAA TAATTAGGGGAAATAATAA------------------------------TTAGGGAAGAT GGTATATCTG-GGCACTCTC----------------------------TGTACT------ ------------------------------------------------------------ -------------------------------------------------------TTCTG CTCAATTTTTCTGTAAACC------------TAAAACT----GCTCTAAAA------AA- -------TAAAGTTTATTT----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----